Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UHRF2 Gene

protein-coding   GIFtS: 58
GCID: GC09P006405

Ubiquitin-Like With PHD And Ring Finger Domains 2, E3 Ubiquitin...

(Previous name: ubiquitin-like with PHD and ring finger domains 2)
  See UHRF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin-Like With PHD And Ring Finger Domains 2, E3 Ubiquitin Protein
Ligase1 2
     RNF1072 3
Np95-Like RING Finger Protein1 2 3     RING Finger Protein 1072 3
NIRF2 3 5     Ubiquitin-Like With PHD And Ring Finger Domains 21
Np95/ICBP90-Like RING Finger Protein2 3     URF22
Nuclear Protein 972 3     E3 Ubiquitin-Protein Ligase UHRF22
Nuclear Zinc Finger Protein Np972 3     Ubiquitin-Like, Containing PHD And RING Finger Domains, 22
Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 22 3     EC 6.3.2.-3
Ubiquitin-Like-Containing PHD And RING Finger Domains Protein 22 3     EC 6.3.28

External Ids:    HGNC: 125571   Entrez Gene: 1154262   Ensembl: ENSG000001478547   OMIM: 6152115   UniProtKB: Q96PU43   

Export aliases for UHRF2 gene to outside databases

Previous GC identifers: GC00U990683 GC09P006404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UHRF2 Gene:
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a
ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a
role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated
(SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the
regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine
aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
(provided by RefSeq, Feb 2012)

GeneCards Summary for UHRF2 Gene:
UHRF2 (ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with UHRF2 include aminoacylase 1 deficiency. GO annotations related to this gene include ubiquitin-protein ligase activity and histone binding.

UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
Function: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through
cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in
differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner
and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not
ubiquitin-, protein ligase for ZNF131

Gene Wiki entry for UHRF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UHRF2 gene promoter:
         ER-alpha   LHX3b/Lhx3b   AML1a   Pax-2   Pax-2a   YY1   MEF-2A   Pax-2b   LHX3a/Lhx3a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UHRF2 promoter sequence
   Search Chromatin IP Primers for UHRF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UHRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

UHRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UHRF2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P006405:  view genomic region     (about GC identifiers)

Start:
6,413,151 bp from pter      End:
6,507,054 bp from pter
Size:
93,904 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase UHRF2  
Size: 802 amino acids; 89985 Da
Subunit: Homodimer; disulfide-linked. Binds methylated CpG containing oligonucleotides. Interacts with H3: the
interaction has a preference for the 'Lys-9' trimethylated form of H3 (H3K9me3) (By similarity). Interacts with
PCNP, HDAC1 and CDK2 (inactive form). Component of a complex at least composed of UHRF2, CDK2 and CCNE1.
Interacts directly with CCNE1; the interaction ubiquitinates CCNE1 and appears independent of CCNE1
phosphorylation. Interacts with CCND1; the interaction ubiquitinates CCND1 and appears independent of CCND1
phosphorylation. Interacts with p53/TP53 and RB1. Interacts with UBE2I
Sequence caution: Sequence=CAH74120.1; Type=Erroneous gene model prediction; Sequence=CAI13295.1; Type=Erroneous
gene model prediction;
4 PDB 3D structures from and Proteopedia for UHRF2:
1WY8 (3D)        1Z6U (3D)        2E6S (3D)        3OLN (3D)    
Secondary accessions: Q5VYR1 Q5VYR3 Q659C8 Q8TAG7
Alternative splicing: 2 isoforms:  Q96PU4-1   Q96PU4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UHRF2: NX_Q96PU4

Explore proteomics data for UHRF2 at MOPED

Post-translational modifications: 

  • May be autoubiquitinated; which may lead to proteasomal degradation1
  • Phosphorylated. Phosphorylation may be mediated by CDK21
  • Autosumoylated1
  • Ubiquitination2 at Lys128, Lys322, Lys548, Lys575, Lys589
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UHRF2 (Q96PU4) (see all 8)
     GVHRPHV  HNVCKDCL  QRLFYRGKQ  WRFRVQVSE 


    See UHRF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_690856.1  
    ENSEMBL proteins: 
     ENSP00000434182   ENSP00000276893   ENSP00000370778   ENSP00000399217  

    UHRF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UHRF2
    OriGene Protein Over-expression Lysate for UHRF2
    OriGene MassSpec for UHRF2
    OriGene Custom Protein Services for UHRF2
    GenScript Custom Purified and Recombinant Proteins Services for UHRF2
    Novus Biologicals UHRF2 Proteins
    Novus Biologicals UHRF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UHRF2

     
    Search eBioscience for Proteins for UHRF2 

     
    antibodies-online proteins for UHRF2 (3 products) 

     
    antibodies-online peptides for UHRF2

    UHRF2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UHRF2
    OriGene Custom Antibody Services for UHRF2
    Novus Biologicals UHRF2 Antibodies
    Abcam antibodies for UHRF2
    Cloud-Clone Corp. Antibodies for UHRF2
    Search ThermoFisher Antibodies for UHRF2
    antibodies-online antibodies for UHRF2 (38 products) 

    UHRF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UHRF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UHRF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UHRF2
    Cloud-Clone Corp. CLIAs for UHRF2
    Search eBioscience for ELISAs for UHRF2 
    antibodies-online kits for UHRF2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 11):
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR003105 SRA_YDG
     IPR013083 Znf_RING/FYVE/PHD
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry Q96PU4

    ProtoNet protein and cluster: Q96PU4

    3 Blocks protein domains:
    IPB000626 Ubiquitin domain
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 ubiquitin-like domain
    Similarity: Contains 1 YDG domain


    Find genes that share domains with UHRF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UHRF2_HUMAN, Q96PU4
    Function: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through
    cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in
    differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner
    and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not
    ubiquitin-, protein ligase for ZNF131
    Induction: Up-regulated in proliferating fetal lung fibroblasts and in U-937 myeloid leukemia cells.
    Down-regulated in these cells by growth arrest and differentiation. In other cell types which cannot leave the
    cell cycle, such as tumoral HT-1080 and Hep-G2, levels are consistently up-regulated

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA14741369
    GO:0005515protein binding IPI12176013
    GO:0008270zinc ion binding IEA--
    GO:0042393histone binding ISS--
         
    Find genes that share ontologies with UHRF2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UHRF2:
     Increased cell death in DLD-1   Increased cell death in breast  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UHRF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target UHRF2:
    hsa-mir-222-3p (MIRT046615), hsa-let-7a-5p (MIRT004321), hsa-mir-335-5p (MIRT018641), hsa-mir-30a-5p (MIRT028675)

    Block miRNA regulation of human, mouse, rat UHRF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UHRF2 (see all 30):
    hsa-miR-34b* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-519a hsa-miR-449a hsa-let-7g hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidUHRF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UHRF2
    Predesigned siRNA for gene silencing in human, mouse, rat UHRF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UHRF2

    Clone
    Products:
         
    OriGene clones in human, mouse for UHRF2 (see all 7)
    OriGene ORF clones in mouse, rat for UHRF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UHRF2 (NM_152896)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UHRF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF2
    Addgene plasmids for UHRF2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UHRF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for UHRF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UHRF2_HUMAN, Q96PU4: Nucleus. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent
    on the interaction with H3K9me3 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005720nuclear heterochromatin ISS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with UHRF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



    UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including UHRF2: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UHRF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UHRF2 (Q96PU41, 2, 3 ENSP000002768934) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249411, 3, ENSP000002669704EBI-625304,EBI-375096 I2D: score=3 STRING: ENSP00000266970
    CCNA2P202481, 3, ENSP000002740264EBI-625304,EBI-457097 I2D: score=1 STRING: ENSP00000274026
    TP53P046371, 3, ENSP000002693054EBI-625304,EBI-366083 I2D: score=1 STRING: ENSP00000269305
    SMAD4Q134852, 3MINT-61980 I2D: score=3 
    CCNE1P248641, 3, ENSP000002626434EBI-625304,EBI-519526 I2D: score=1 STRING: ENSP00000262643
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IDA14741369
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation IEP12176013
    GO:0016567protein ubiquitination IDA14741369
    GO:0030154cell differentiation IEP12176013

    Find genes that share ontologies with UHRF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UHRF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UHRF2 gene: 
    NM_152896.2  

    Unigene Cluster for UHRF2:

    Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
    Hs.493401  [show with all ESTs]
    Unigene Representative Sequence: NR_046386
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468435(uc003zjy.3 uc003zjz.3) ENST00000469298 ENST00000276893
    ENST00000381373 ENST00000481049 ENST00000461236 ENST00000450508 ENST00000484159(uc003zka.1)
    ENST00000477183 ENST00000485617(uc003zkb.3) ENST00000479000 ENST00000492853
    ENST00000481243
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UHRF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UHRF2 (see all 30):
    hsa-miR-34b* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-519a hsa-miR-449a hsa-let-7g hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidUHRF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UHRF2
    Predesigned siRNA for gene silencing in human, mouse, rat UHRF2
    Clone
    Products:
         
    OriGene clones in human, mouse for UHRF2 (see all 7)
    OriGene ORF clones in mouse, rat for UHRF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UHRF2 (NM_152896)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UHRF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF2
    Addgene plasmids for UHRF2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UHRF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UHRF2
      QuantiTect SYBR Green Assays in human, mouse, rat UHRF2
      QuantiFast Probe-based Assays in human, mouse, rat UHRF2

    Additional mRNA sequence: 

    AB071698.1 AF274049.1 AK308433.1 BC028397.2 NR_046386.1 

    14 DOTS entries:

    DT.114010  DT.40205660  DT.100024889  DT.431026  DT.92017590  DT.40127337  DT.40232195  DT.95376366 
    DT.121153580  DT.95376363  DT.99958761  DT.121153637  DT.121153649  DT.92414777 

    Selected AceView cDNA sequences (see all 143):

    CA313723 BM976371 BQ019914 BQ010094 BQ086357 BE139565 AI352207 CA443119 
    BU621172 F10513 AI440277 NM_152306 BF438332 AI352091 AL833522 BU687976 
    AL137728 F12908 CK823004 BX399197 AA449626 CK823005 AA046431 AI797057 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UHRF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
    SP1:              -                                                                                         -     -     -                                       
    SP2:              -                                                                             -           -     -     -                                       
    SP3:                                                                                            -                                                               
    SP4:                                -     -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 19
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for UHRF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UHRF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATCCACT
    UHRF2 Expression
    About this image


    UHRF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    UHRF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UHRF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.493401
        Pathway & Disease-focused RT2 Profiler PCR Array including UHRF2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UHRF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UHRF2
    QuantiTect SYBR Green Assays in human, mouse, rat UHRF2
    QuantiFast Probe-based Assays in human, mouse, rat UHRF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for UHRF2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uhrf21 , 5 ubiquitin-like, containing PHD and RING finger domains more1, 5 89.1(n)1
    91.01(a)1
      19 (24.73 cM)5
    1091131  NM_144873.21  NP_659122.21 
     300305135 
    chicken
    (Gallus gallus)
    Aves UHRF21 ubiquitin-like, containing PHD and RING finger domains, more 75.81(n)
    71.93(a)
      431601  XM_003643002.2  XP_003643050.1 
    lizard
    (Anolis carolinensis)
    Reptilia UHRF26
    ubiquitin-like with PHD and ring finger domains 2,...
    69(a)
    1 ↔ 1
    2(52637068-52708809)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480603842   -- 80.91(n)    48060384 
    zebrafish
    (Danio rerio)
    Actinopterygii UHRF2 (2 of 3)6
    UHRF2 (3 of 3)6
    (see all 3)
    ubiquitin-like with PHD and ring finger domains 2,...
    ubiquitin-like with PHD and ring finger domains 2,...
    (see all 3)
    78(a)
    57(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    21(761567-761955) ENSDARG00000089654
    21(767326-769740) ENSDARG00000090666


    ENSEMBL Gene Tree for UHRF2 (if available)
    TreeFam Gene Tree for UHRF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UHRF2 gene
    2 SIMAP similar genes for UHRF2 using alignment to 2 protein entries:     UHRF2_HUMAN (see all proteins):
    UHRF1    NEDD8

    Find genes that share paralogs with UHRF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UHRF2
    PGOHUM00000258439


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UHRF2 (see all 2156)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359614
    A colorectal cancer sample4--see VAR_0359612 I N mis40--------
    rs286157461,2
    C,F--6411160(+) TGCCAT/CCGAAA 2 -- us2k111Minor allele frequency- C:0.08NA WA CSA EA 372
    rs78519211,2
    C,A--6411167(+) GAAAGT/AAATGG 2 -- us2k1 tfbs39Minor allele frequency- A:0.02WA NA CSA EA 250
    rs1846043321,2
    --6411210(+) TATCAC/TCTCAT 2 -- us2k10--------
    rs286243571,2
    C--6411499(+) CAGCCC/TCCCGA 2 -- us2k10--------
    rs108154311,2
    C,F,A--6411638(+) GCCTCG/CCAAAG 2 -- us2k18Minor allele frequency- C:0.21NA WA CSA 14
    rs1125693371,2
    C,F--6411714(+) GATTTG/CTCTGT 2 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1893903051,2
    --6411723(+) GTGCTC/TGTAAT 2 -- us2k10--------
    rs1813993471,2
    --6411781(+) TTATGC/GGAATA 2 -- us2k10--------
    rs1869821881,2
    --6411801(+) TATGTC/GAATAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UHRF2 (6413151 - 6507054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for UHRF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2535857CNV Deletion19546169
    nsv831498CNV Loss17160897
    esv6811CNV Gain19470904
    nsv824839CNV Gain20364138
    dgv8021n71CNV Gain21882294
    nsv892162CNV Gain21882294
    nsv831497CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UHRF2
    DNA2.0 Custom Variant and Variant Library Synthesis for UHRF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615211    OMIM disorders: --

    UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
  • Note=Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies
    originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung

  • 1 disease for UHRF2:    
    About MalaCards
    aminoacylase 1 deficiency


    Find genes that share disorders with UHRF2           About GenesLikeMe

    Genetic Association Database (GAD): UHRF2
    Human Genome Epidemiology (HuGE) Navigator: UHRF2 (1 document)

    Export disorders for UHRF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UHRF2 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with UHRF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. (PubMed id 12176013)1, 2, 3 Mori T.... Kochi H. (Biochem. Biophys. Res. Commun. 2002)
    2. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. (PubMed id 14741369)1, 2, 9 Mori T.... Kochi H. (FEBS Lett. 2004)
    3. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131. (PubMed id 23404503)1, 2 Oh Y. and Chung K.C. (J. Biol. Chem. 2013)
    4. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. (PubMed id 21952639)1, 2 Mori T.... Kochi H. (Cell Cycle 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. NIRF induces G1 arrest and associates with Cdk2. (PubMed id 15178429)1, 2 Li Y.... Kochi H. (Biochem. Biophys. Res. Commun. 2004)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    8. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. (PubMed id 15361834)1, 2 Unoki M.... Nakamura Y. (Oncogene 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 115426 HGNC: 12557 AceView: UHRF2 Ensembl:ENSG00000147854 euGenes: HUgn115426
    ECgene: UHRF2 H-InvDB: UHRF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UHRF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UHRF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UHRF2 gene:
    Search GeneIP for patents involving UHRF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UHRF2   OriGene RNAi products in human, mouse, rat for UHRF2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UHRF2  
     OriGene MassSpec for UHRF2   OriGene clones in human, mouse for UHRF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for UHRF2   OriGene Purified Protein for UHRF2  
     OriGene ORF clones in mouse, rat for UHRF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UHRF2   OriGene Custom Protein Services for UHRF2  

     
     
     Block miRNA regulation of human, mouse, rat UHRF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UHRF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UHRF2 Predesigned siRNA for gene silencing in human, mouse, rat UHRF2
     QuantiFast Probe-based Assays in human, mouse, rat UHRF2 QuantiTect SYBR Green Assays in human, mouse, rat UHRF2
     PCR Arrays including human, mouse, rat UHRF2 Search Chromatin IP Primers for UHRF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UHRF2  GeneGlobe Interaction Network for UHRF2
     Regulatory tfbs in UHRF2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UHRF2 GenScript cDNA clones with any tag delivered in your preferred vector for UHRF2
     GenScript Custom Assay Services for UHRF2 GenScript Custom overexpressing Cell Line Services for UHRF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UHRF2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UHRF2 antibodies
     UHRF2 proteins
     UHRF2 lysates
     Antibodies for UHRF2
     See all of Abcam's Antibodies, Kits and Proteins for UHRF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UHRF2
     Antibodies for UHRF2
     ELISAs for UHRF2
     CLIAs for UHRF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for UHRF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF2
     SwitchGear 3'UTR luciferase reporter plasmids for UHRF2
     SwitchGear Promoter luciferase reporter plasmids for UHRF2
     Search ThermoFisher Antibodies for UHRF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF2
     Browse compounds at ApexBio
     Addgene plasmids for UHRF2
      Search eBioscience for proteins for UHRF2
      Search eBioscience for elisas for UHRF2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for UHRF2
     antibodies-online antibodies for UHRF2 (38 products)
     antibodies-online kits for UHRF2 (4 products)
     antibodies-online peptides for UHRF2
     antibodies-online proteins for UHRF2 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UHRF2 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4