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Aliases for UHRF2 Gene

Aliases for UHRF2 Gene

  • Ubiquitin Like With PHD And Ring Finger Domains 2 2 3
  • Ubiquitin-Like With PHD And Ring Finger Domains 2, E3 Ubiquitin Protein Ligase 2 3 5
  • Ubiquitin-Like-Containing PHD And RING Finger Domains Protein 2 3 4
  • Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 2 3 4
  • Np95/ICBP90-Like RING Finger Protein 3 4
  • Np95-Like Ring Finger Protein 2 3
  • RING Finger Protein 107 3 4
  • Nuclear Protein 97 3 4
  • RNF107 3 4
  • NIRF 3 4
  • Ubiquitin-Like, Containing PHD And RING Finger Domains, 2 3
  • Nuclear Zinc Finger Protein NP97 3
  • Nuclear Zinc Finger Protein Np97 4
  • Np95-Like RING Finger Protein 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • TDRD23 3
  • URF2 3

External Ids for UHRF2 Gene

Previous GeneCards Identifiers for UHRF2 Gene

  • GC00U990683
  • GC09P006404

Summaries for UHRF2 Gene

Entrez Gene Summary for UHRF2 Gene

  • This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

GeneCards Summary for UHRF2 Gene

UHRF2 (Ubiquitin Like With PHD And Ring Finger Domains 2) is a Protein Coding gene. GO annotations related to this gene include ligase activity and histone binding. An important paralog of this gene is UHRF1.

UniProtKB/Swiss-Prot for UHRF2 Gene

  • E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.

Gene Wiki entry for UHRF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UHRF2 Gene

Genomics for UHRF2 Gene

Regulatory Elements for UHRF2 Gene

Promoters for UHRF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UHRF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UHRF2 Gene

Chromosome:
9
Start:
6,413,148 bp from pter
End:
6,507,056 bp from pter
Size:
93,909 bases
Orientation:
Plus strand

Genomic View for UHRF2 Gene

Genes around UHRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UHRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UHRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UHRF2 Gene

Proteins for UHRF2 Gene

  • Protein details for UHRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PU4-UHRF2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase UHRF2
    Protein Accession:
    Q96PU4
    Secondary Accessions:
    • Q5VYR1
    • Q5VYR3
    • Q659C8
    • Q8TAG7

    Protein attributes for UHRF2 Gene

    Size:
    802 amino acids
    Molecular mass:
    89985 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Binds methylated CpG containing oligonucleotides. Interacts with H3: the interaction has a preference for the Lys-9 trimethylated form of H3 (H3K9me3) (By similarity). Interacts with PCNP, HDAC1 and CDK2 (inactive form). Component of a complex at least composed of UHRF2, CDK2 and CCNE1. Interacts directly with CCNE1; the interaction ubiquitinates CCNE1 and appears independent of CCNE1 phosphorylation. Interacts with CCND1; the interaction ubiquitinates CCND1 and appears independent of CCND1 phosphorylation. Interacts with p53/TP53 and RB1. Interacts with UBE2I.
    SequenceCaution:
    • Sequence=CAH74120.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13295.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UHRF2 Gene

    Alternative splice isoforms for UHRF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UHRF2 Gene

Proteomics data for UHRF2 Gene at MOPED

Post-translational modifications for UHRF2 Gene

Other Protein References for UHRF2 Gene

Antibody Products

Domains & Families for UHRF2 Gene

Suggested Antigen Peptide Sequences for UHRF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PU4

UniProtKB/Swiss-Prot:

UHRF2_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Contains 1 PHD-type zinc finger.
Domain:
  • Contains 1 ubiquitin-like domain.
  • Contains 1 YDG domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with UHRF2: view

Function for UHRF2 Gene

Molecular function for UHRF2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
UniProtKB/Swiss-Prot Induction:
Up-regulated in proliferating fetal lung fibroblasts and in U-937 myeloid leukemia cells. Down-regulated in these cells by growth arrest and differentiation. In other cell types which cannot leave the cell cycle, such as tumoral HT-1080 and Hep-G2, levels are consistently up-regulated.

Enzyme Numbers (IUBMB) for UHRF2 Gene

Gene Ontology (GO) - Molecular Function for UHRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UHRF2: view
genes like me logo Genes that share phenotypes with UHRF2: view

Animal Models for UHRF2 Gene

MGI Knock Outs for UHRF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for UHRF2

CRISPR Products

miRNA for UHRF2 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UHRF2 Gene

Localization for UHRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UHRF2 Gene

Nucleus. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UHRF2 Gene COMPARTMENTS Subcellular localization image for UHRF2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for UHRF2 Gene

Pathways & Interactions for UHRF2 Gene

SuperPathways for UHRF2 Gene

No Data Available

UniProtKB/Swiss-Prot Q96PU4-UHRF2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UHRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA 14741369
GO:0008283 cell proliferation IEP 12176013
GO:0016567 protein ubiquitination IDA 14741369
GO:0071158 positive regulation of cell cycle arrest IDA 15178429
genes like me logo Genes that share ontologies with UHRF2: view

No data available for Pathways by source and SIGNOR curated interactions for UHRF2 Gene

Drugs & Compounds for UHRF2 Gene

No Compound Related Data Available

Transcripts for UHRF2 Gene

Unigene Clusters for UHRF2 Gene

Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UHRF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:

ExUns: 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for UHRF2 Gene

GeneLoc Exon Structure for
UHRF2
ECgene alternative splicing isoforms for
UHRF2

Expression for UHRF2 Gene

mRNA expression in normal human tissues for UHRF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UHRF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.1), Blymphocyte (9.7), and Heart (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UHRF2 Gene



SOURCE GeneReport for Unigene cluster for UHRF2 Gene Hs.493401

genes like me logo Genes that share expression patterns with UHRF2: view

Protein tissue co-expression partners for UHRF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UHRF2 Gene

Orthologs for UHRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UHRF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UHRF2 36
  • 100 (a)
OneToOne
UHRF2 35
  • 99.63 (n)
  • 99.75 (a)
cow
(Bos Taurus)
Mammalia UHRF2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UHRF2 36
  • 91 (a)
OneToOne
UHRF2 35
  • 92.05 (n)
  • 91.64 (a)
mouse
(Mus musculus)
Mammalia Uhrf2 16
Uhrf2 36
  • 90 (a)
OneToOne
Uhrf2 35
  • 89.1 (n)
  • 91.01 (a)
oppossum
(Monodelphis domestica)
Mammalia UHRF2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Uhrf2 35
  • 87.93 (n)
  • 90.51 (a)
chicken
(Gallus gallus)
Aves UHRF2 35
  • 75.81 (n)
  • 71.93 (a)
UHRF2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UHRF2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100124801 35
  • 69.55 (n)
  • 68.98 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8721 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01073380.1 36
  • 45 (a)
OneToMany
UHRF2 (2 of 3) 36
  • 78 (a)
OneToMany
UHRF2 (3 of 3) 36
  • 57 (a)
OneToMany
Species with no ortholog for UHRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UHRF2 Gene

ENSEMBL:
Gene Tree for UHRF2 (if available)
TreeFam:
Gene Tree for UHRF2 (if available)

Paralogs for UHRF2 Gene

Paralogs for UHRF2 Gene

(2) SIMAP similar genes for UHRF2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for UHRF2 Gene

genes like me logo Genes that share paralogs with UHRF2: view

Variants for UHRF2 Gene

Sequence variations from dbSNP and Humsavar for UHRF2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_035961 A colorectal cancer sample
rs1563 -- 6,495,905(-) CCTAT(C/T)GAGAT intron-variant
rs503315 -- 6,439,075(+) AAGTT(C/T)ATGAA intron-variant
rs375835 -- 6,456,230(-) ccagt(A/T)agaat intron-variant
rs380674 -- 6,438,131(+) ATGAT(A/T)GTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UHRF2 Gene

Variant ID Type Subtype PubMed ID
dgv8021n71 CNV Gain 21882294
nsv831497 CNV Gain 17160897
nsv824839 CNV Gain 20364138
esv2535857 CNV Deletion 19546169
nsv892162 CNV Gain 21882294
esv6811 CNV Gain 19470904
nsv831498 CNV Loss 17160897

Variation tolerance for UHRF2 Gene

Residual Variation Intolerance Score: 7.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UHRF2 Gene

HapMap Linkage Disequilibrium report
UHRF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UHRF2 Gene

Disorders for UHRF2 Gene

UniProtKB/Swiss-Prot

UHRF2_HUMAN
  • Note=Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung.

Relevant External Links for UHRF2

Genetic Association Database (GAD)
UHRF2
Human Genome Epidemiology (HuGE) Navigator
UHRF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UHRF2

No disorders were found for UHRF2 Gene.

No data available for MalaCards and Genatlas for UHRF2 Gene

Publications for UHRF2 Gene

  1. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. (PMID: 12176013) Mori T. … Kochi H. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. (PMID: 14741369) Mori T. … Kochi H. (FEBS Lett. 2004) 3 23
  3. Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2. (PMID: 24813944) Zhou T. … Xu R.M. (Mol. Cell 2014) 3
  4. Ubiquitin-like with PHD and ring finger domains 2 is a predictor of survival and a potential therapeutic target in colon cancer. (PMID: 24573556) Lu S. … Tang H. (Oncol. Rep. 2014) 3
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3

Products for UHRF2 Gene

Sources for UHRF2 Gene

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