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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UHRF2 Gene

protein-coding   GIFtS: 54
GCID: GC09P006405

ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin...

(Previous name: ubiquitin-like with PHD and ring finger domains 2 )
 Explore 4 diseases affiliated with
UHRF2 via
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 Human Malady Compendium 
Biological research products
for UHRF2    

Aliases
for UHRF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin-Like With PHD And Ring Finger Domains 2, E3 Ubiquitin Protein
Ligase1 2
     Ubiquitin-Like-Containing PHD And RING Finger Domains Protein 22 3
NIRF1 2 3     RING Finger Protein 1072 3
RNF1071 2 3     MGC334631
URF21 2     Ubiquitin-Like With PHD And Ring Finger Domains 21
Np95-Like RING Finger Protein2 3     E3 Ubiquitin-Protein Ligase UHRF22
Np95/ICBP90-Like RING Finger Protein2 3     Ubiquitin-Like, Containing PHD And RING Finger Domains, 22
Nuclear Protein 972 3     EC 6.3.2.-3
Nuclear Zinc Finger Protein Np972 3     EC 6.3.28
Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 22 3     

External Ids:    HGNC: 125571   Entrez Gene: 1154262   Ensembl: ENSG000001478547   UniProtKB: Q96PU43   

Export aliases for UHRF2 gene to outside databases

Previous GC identifers: GC00U990683 GC09P006404


Summaries
for UHRF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UHRF2:
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a
ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in
tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain,
and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell
proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative
splicing results in multiple transcript variants some of which are non-protein coding. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
Function: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through
cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in
differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and
induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Appears to contribute to
tumorigenesis

Gene Wiki entry for UHRF2


Genomic Views
for UHRF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UHRF2 gene promoter:
         ER-alpha   LHX3b/Lhx3b   AML1a   Pax-2   Pax-2a   YY1   MEF-2A   Pax-2b   LHX3a/Lhx3a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UHRF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UHRF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UHRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

UHRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UHRF2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P006405:  view genomic region     (about GC identifiers)

Start:
 6,413,151 bp from pter      End:
 6,507,054 bp from pter
Size:
 93,904 bases      Orientation:
 plus strand

Proteins
for UHRF2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase UHRF2  
Size: 802 amino acids; 89985 Da
Subunit: Homodimer; disulfide-linked. Binds methylated CpG containing oligonucleotides. Interacts with H3: the
interaction has a preference for the 'Lys-9' trimethylated form of H3 (H3K9me3) (By similarity). Interacts with PCNP,
HDAC1 and CDK2 (inactive form). Component of a complex at least composed of UHRF2, CDK2 and CCNE1. Interacts directly
with CCNE1; the interaction ubiquitinates CCNE1 and appears independent of CCNE1 phosphorylation. Interacts with
CCND1; the interaction ubiquitinates CCND1 and appears independent of CCND1 phosphorylation. Interacts with p53/TP53
and RB1
Subcellular location: Nucleus. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the
interaction with H3K9me3 (By similarity)
Sequence caution: Sequence=CAH74120.1; Type=Erroneous gene model prediction; Sequence=CAI13295.1; Type=Erroneous gene
model prediction;
4 PDB 3D structures from and Proteopedia for UHRF2:
1WY8 (3D)        1Z6U (3D)        2E6S (3D)        3OLN (3D)    
Secondary accessions: Q5VYR1 Q5VYR3 Q659C8 Q8TAG7
Alternative splicing: 2 isoforms:  Q96PU4-1   Q96PU4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UHRF2: NX_Q96PU4

Post-translational modifications:

  • May be autoubiquitinated; which may lead to proteasomal degradation1
  • Phosphorylated. Phosphorylation may be mediated by CDK21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96PU4

    • 4/8 DME Specific Peptides for UHRF2 (Q96PU4) (see all 8)
     GVHRPHV  HNVCKDCL  QRLFYRGKQ  WRFRVQVSE 

    UHRF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_690856.1  
    ENSEMBL proteins: 
     ENSP00000434182   ENSP00000276893   ENSP00000370778   ENSP00000399217  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UHRF2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005720nuclear heterochromatin ISS--
    GO:0005730NOT nucleolus IDA--


    UHRF2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UHRF2

    Protein Domains /
    Families
    for UHRF2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UHRF2 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR014722 Rib_L2_dom2
     IPR003105 SRA_YDG

    Graphical View of Domain Structure for InterPro Entry Q96PU4

    ProtoNet protein and cluster: Q96PU4

    3 Blocks protein families:
    IPB000626 Ubiquitin domain
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 ubiquitin-like domain
    Similarity: Contains 1 YDG domain


    Function
    for UHRF2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
    Function: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through
    cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in
    differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and
    induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Appears to contribute to
    tumorigenesis
    Induction: Up-regulated in proliferating fetal lung fibroblasts and in U-937 myeloid leukemia cells. Down-regulated in
    these cells by growth arrest and differentiation. In other cell types which cannot leave the cell cycle, such as
    tumoral HT-1080 and Hep-G2, levels are consistently up-regulated

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate UHRF2 (see all 30):
    hsa-miR-34b* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-519a hsa-miR-449a hsa-let-7g hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: UHRF2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: UHRF2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UHRF2

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA14741369
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0042393histone binding ISS--


    UHRF2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for UHRF2:
     Increased cell death in DLD-1   Increased cell death in breast  Synthetic lethal with Ras 


    Pathways & Interactions
    for UHRF2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UHRF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for UHRF2 (Q96PU41, 2, 3 ENSP000002768934) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249411, 3, ENSP000002669704EBI-625304,EBI-375096 I2D: score=3 STRING: ENSP00000266970
    CCNA2P202481, 3, ENSP000002740264EBI-625304,EBI-457097 I2D: score=1 STRING: ENSP00000274026
    TP53P046371, 3, ENSP000002693054EBI-625304,EBI-366083 I2D: score=1 STRING: ENSP00000269305
    SMAD4Q134852, 3MINT-61980 I2D: score=3 
    CCNE1P248641, 3, ENSP000002626434EBI-625304,EBI-519526 I2D: score=1 STRING: ENSP00000262643
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IDA14741369
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation IEP12176013
    GO:0016567protein ubiquitination IDA14741369
    GO:0030154cell differentiation IEP12176013


    UHRF2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UHRF2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UHRF2
    Search CenterWatch for drugs/clinical trials and news about UHRF2 

    Transcripts
    for UHRF2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UHRF2 gene: 
    NM_152896.2  

    Unigene Cluster for UHRF2:

    Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
    Hs.493401  [show with all ESTs]
    Unigene Representative Sequence: NR_046386
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468435(uc003zjy.3 uc003zjz.3) ENST00000469298 ENST00000276893
    ENST00000381373 ENST00000481049 ENST00000461236 ENST00000450508 ENST00000484159(uc003zka.1)
    ENST00000477183 ENST00000485617(uc003zkb.3) ENST00000479000 ENST00000492853
    ENST00000481243

    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate UHRF2 (see all 30):
    hsa-miR-34b* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-519a hsa-miR-449a hsa-let-7g hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: UHRF2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: UHRF2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB071698.1 AF274049.1 AK308433.1 BC028397.2 NR_046386.1 

    14 DOTS entries:

    DT.114010  DT.40205660  DT.100024889  DT.431026  DT.92017590  DT.40127337  DT.40232195  DT.95376366 
    DT.121153580  DT.95376363  DT.99958761  DT.121153637  DT.121153649  DT.92414777 

    24/143 AceView cDNA sequences (see all 143):

    AI352207 BE044309 AI440277 AI590281 AA278210 BX642474 BU621172 AA449626 
    AA046431 F10513 BM976371 CA443119 AI797057 AL833522 CK823004 BQ006385 
    AF274049 NM_152896 AA738364 AA805615 BF434825 BU687976 AL137728 BQ019914 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UHRF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
    SP1:              -                                                                                         -     -     -                                       
    SP2:              -                                                                             -           -     -     -                                       
    SP3:                                                                                            -                                                               
    SP4:                                -     -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 19
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for UHRF2

    Expression
    for UHRF2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UHRF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAATCCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See UHRF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UHRF2

    SOURCE GeneReport for Unigene cluster: Hs.493401
        SABiosciences Expression via Pathway-Focused PCR Array including UHRF2: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for UHRF2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UHRF2 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Uhrf21 , 5 ubiquitin-like, containing PHD and RING finger domains more1, 5 89.14(n)1
    91.01(a)1    		   19 (24.73 cM)5
    1091131  NM_144873.21  NP_659122.21 
     300305135 
    chicken
    (Gallus gallus)    		 Aves UHRF21 ubiquitin-like, containing PHD and RING finger domains, more 75.81(n)
    71.93(a)    		   431601  XM_003643002.1  XP_003643050.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UHRF26
    		 --
    		 67(a)
    		 1 ↔ 1
    		 2(52637500-52708809)
    African clawed frog
    (Xenopus laevis)    		 Amphibia 480603842   -- 80.91(n)    48060384 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01085269.16
    CABZ01085272.16
    (see all 3)    		 --
    		 80(a)
    53(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 21(761567-761955)
    21(767326-769740)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 36(a)
    		 1 ↔ 1
    		 GroupUn.625(21898-25288)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons VIM36
    ORL16
    (see all 6)    		 E3 ubiquitin-protein ligase ORTHRUS-LIKE 1
    (see all 6)    		 24(a)
    24(a)
    (see all 6)    		 many → 1
    many → 1
    (see all 6)    		 5(15837210-15840638)
    4(5463885-5466671)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 zinc finger, C3HC4 type domain containing protein
    		 19(a)
    17(a)
    		 many → 1
    many → 1
    		 5(155313-160214)
    4(12588529-12593125)


    ENSEMBL Gene Tree for UHRF2 (if available)
    TreeFam Gene Tree for UHRF2 (if available) 

    Paralogs
    for UHRF2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UHRF2 gene
    2 SIMAP similar genes for UHRF2 using alignment to 2 protein entries:     UHRF2_HUMAN (see all proteins):
    UHRF1    NEDD8

    UHRF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UHRF2
    PGOHUM00000258439


    Genomic Variants
    for UHRF2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1830 NCBI SNPs in UHRF2 are shown (see all 1830)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs342192171,2
    		C,--6400084(+) ATCTC-/TTATTT 1 -- int11Minor allele frequency- T:0.00CSA 2
    rs286157461,2
    		C,F,--6411160(+) TGCCAT/CCGAAA 2 -- us2k111Minor allele frequency- C:0.08NA WA CSA EA 372
    rs78519211,2
    		C,A,--6411167(+) GAAAGT/AAATGG 2 -- us2k1 tfbs39Minor allele frequency- A:0.02WA NA CSA EA 250
    rs1846043321,2
    		--6411210(+) TATCAC/TCTCAT 2 -- us2k10--------
    rs286243571,2
    		--6411499(+) CAGCCC/TCCCGA 2 -- us2k10--------
    rs108154311,2
    		C,F,A,--6411638(+) GCCTCG/CCAAAG 2 -- us2k18Minor allele frequency- C:0.21NA WA CSA 14
    rs1125693371,2
    		--6411714(+) GATTTG/CTCTGT 2 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1893903051,2
    		--6411723(+) GTGCTC/TGTAAT 2 -- us2k10--------
    rs1813993471,2
    		--6411781(+) TTATGC/GGAATA 2 -- us2k10--------
    rs1869821881,2
    		--6411801(+) TATGTC/GAATAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UHRF2 (6413151 - 6507054 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for UHRF2
         1 CNV: 100571
         1 Indel: 60736

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    Disorders / Diseases
    for UHRF2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UHRF2 for disorders           About GeneDecksing

    UniProtKB/Swiss-Prot: UHRF2_HUMAN, Q96PU4
  • Note=Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies
    • originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung

    4 diseases for UHRF2:    About MalaCards
    colorectal cancer    lung cancer    myeloid leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: UHRF2 (1 document)

    Export disorders for UHRF2 gene to outside databases

    Publications
    for UHRF2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UHRF2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with UHRF2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. (PubMed id 12176013)1, 2, 3 Mori T.... Kochi H. (2002)
    2. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. (PubMed id 14741369)1, 2, 9 Mori T.... Kochi H. (2004)
    3. NIRF constitutes a nodal point in the cell cycle netw ork and is a candidate tumor suppressor. (PubMed id 21952639)1, 2 Mori T....Kochi H. (2011)
    4. NIRF induces G1 arrest and associates with Cdk2. (PubMed id 15178429)1, 2 Li Y.... Kochi H. (2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. (PubMed id 15361834)1, 2 Unoki M.... Nakamura Y. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. NIRF/UHRF2 occupies a central position in the cell cyc le network and allows coupling with the epigenetic landscape. (PubMed id 22673569)1 Mori T....Unoki M. (2012)
    10. UHRF2, another E3 ubiquitin ligase for p53. (PubMed id 22902639)1 Bai L....Duan C. (2012)

    External Searches for UHRF2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UHRF2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115426 HGNC: 12557 AceView: UHRF2 Ensembl:ENSG00000147854 euGenes: HUgn115426
    ECgene: UHRF2 H-InvDB: UHRF2

    Other Databases showing UHRF2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UHRF2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UHRF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UHRF2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for UHRF2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UHRF2 gene:
    Search GeneIP for patents involving UHRF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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