UHRF1BP1 Gene
protein-coding GIFtS: 45
GCID: GC06P035772
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UHRF1 binding protein 1(Previous name: chromosome 6 open reading frame 107 )
(Previous symbol: C6orf107)
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Aliases
for UHRF1BP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UHRF1 Binding Protein 11 2 | | FLJ203021 | | C6orf1071 2 3 | | Chromosome 6 Open Reading Frame 1071 | | ICBP901 2 | | ICBP90 Binding Protein 12 | | DJ349A12.11 | | UHRF1 (ICBP90) Binding Protein 12 | | Ubiquitin-Like Containing PHD And RING Finger Domains 1-Binding Protein 12 3 | | UHRF1-Binding Protein 12 | | ICBP90-Binding Protein 12 3 | | |
Export aliases for UHRF1BP1 gene to outside databasesPrevious GC identifers: GC06P034869 GC06P034763 GC06P034482 GC06P034866 |
Summaries
for UHRF1BP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: URFB1_HUMAN, Q6BDS2Function: May act as a negative regulator of cell growth
|
Genomic Views
for UHRF1BP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UHRF1BP1 gene promoter:
YY1 RORalpha1 IRF-2 PPAR-gamma1 GATA-6 E2F-1 E2F ZID PPAR-gamma2 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for UHRF1BP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UHRF1BP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31UHRF1BP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P035772: view genomic region
(about GC identifiers)
Start:
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34,759,794 bp from pter |
End:
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34,850,915 bp from pter |
Size:
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91,122 bases |
Orientation:
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plus strand |
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Proteins
for UHRF1BP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: URFB1_HUMAN, Q6BDS2 (See
protein sequence)Recommended Name: UHRF1-binding protein 1 Size: 1440 amino acids; 159485 Da
Subunit: Homodimer (Potential). Interacts with UHRF1
Sequence caution: Sequence=BAA91074.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
Secondary accessions: Q9NXE0Explore the universe of human proteins at neXtProt for UHRF1BP1: NX_Q6BDS2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6BDS2
UHRF1BP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060224.3
ENSEMBL proteins: ENSP00000192788 ENSP00000400628
Human Recombinant Protein Products:
UHRF1BP1 Antibody Products:
Assay Products for UHRF1BP1: |
Protein
Domains /
Families
for UHRF1BP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UHRF1BP1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6BDS2ProtoNet protein and cluster: Q6BDS2 |
Function
for UHRF1BP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: URFB1_HUMAN, Q6BDS2Function: May act as a negative regulator of cell growth
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1BP1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1BP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): UHRF1BP1 (NM_015054) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UHRF1BP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF1BP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF1BP1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
UHRF1BP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UHRF1BP1:
|
Pathways & Interactions
for UHRF1BP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UHRF1BP1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for UHRF1BP1 (Q6BDS23 ENSP000001927884) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for UHRF1BP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UHRF1BP1
Search CenterWatch for drugs/clinical trials and news about UHRF1BP1 / URFB1
|
Transcripts
for UHRF1BP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UHRF1BP1 gene: NM_017754.3 Unigene Cluster for UHRF1BP1: UHRF1 binding protein 1 Hs.700656 [show with all ESTs]Unigene Representative Sequence: NM_0177542 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000192788(uc003oju.4 uc010jvn.3 uc010jvo.3) ENST00000452449(uc010jvm.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1BP1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1BP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UHRF1BP1 (NM_015054) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UHRF1BP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF1BP1 |
Additional cDNA sequence: AB126777.1 AK001228.1 AK122918.1 AK127691.1 BC108710.1 BC137120.1 BC137127.1 5 DOTS entries: DT.40292765 DT.40216595 DT.424976 DT.101984426 DT.91692238 24/160 AceView cDNA sequences (see all 160): AK096675 BM542802 BM971375 BM984283 NM_017754 BM128309 H96332 BM128474 BM128515 AA399609 AI220005 AA288009 AA081395 BM793489 AA528180 AI201389 BU740368 AI417200 AK122918 BM128721 AA731013 AK127691 CA312836 CB159954
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for UHRF1BP1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UHRF1BP1
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Expression
for UHRF1BP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UHRF1BP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAGGAAAG
About this image
See UHRF1BP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UHRF1BP1
SOURCE GeneReport for Unigene cluster: Hs.700656
SABiosciences Custom PCR Arrays for UHRF1BP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UHRF1BP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UHRF1BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UHRF1BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UHRF1BP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF1BP1 |
Orthologs
for UHRF1BP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UHRF1BP1 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for UHRF1BP1 (if available)
TreeFam Gene Tree for UHRF1BP1 (if available) |
Paralogs
for UHRF1BP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UHRF1BP1 gene
- UHRF1BP1L2
3 SIMAP similar genes for UHRF1BP1 using alignment to 3 protein entries: URFB1_HUMAN (see all proteins):DKFZp686F10110 UHRF1BP1L DKFZp686A1736
UHRF1BP1 for paralogs About GeneDecksing
|
Genomic Variants
for UHRF1BP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UHRF1BP1 (34759794 - 34850915 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UHRF1BP1: --
Human Gene Mutation Database (HGMD): UHRF1BP1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UHRF1BP1 |
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Disorders
/ Diseases
for UHRF1BP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UHRF1BP1 for disorders About GeneDecksing
4  diseases for UHRF1BP1: About MalaCardssystemic lupus erythematosus lupus erythematosus rheumatoid arthritis arthritis
Human Genome Epidemiology (HuGE) Navigator: UHRF1BP1 (4 documents)
Export disorders for UHRF1BP1 gene to outside databases
|
Publications
for UHRF1BP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UHRF1BP1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with UHRF1BP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. (PubMed id 15361834)1, 2 Unoki M.... Nakamura Y. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)1 Manning A.K....Langenberg C. (2012)
- Two missense variants in UHRF1BP1 are independently a ssociated with systemic lupus erythematosus in Hong Kong Chinese. (PubMed id 21326321)1 Zhang Y....Lau Y.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 21068098)1 Orozco G....Barton A. (2010)
- A large-scale replication study identifies TNIP1, PRD M1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. (PubMed id 19838195)1 Gateva V....Graham R.R. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
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External Searches for UHRF1BP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing UHRF1BP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UHRF1BP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UHRF1BP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UHRF1BP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UHRF1BP1 gene:
Search GeneIP for patents involving UHRF1BP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UHRF1BP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UHRF1BP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UHRF1BP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UHRF1BP1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UHRF1BP1 | | OriGene 3'-UTR Clone for UHRF1BP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1BP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1BP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UHRF1BP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UHRF1BP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UHRF1BP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UHRF1BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UHRF1BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UHRF1BP1 |
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 | | | UHRF1BP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF1BP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for UHRF1BP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF1BP1 |
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