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Aliases for UHRF1BP1 Gene

Aliases for UHRF1BP1 Gene

  • UHRF1 Binding Protein 1 2 3 5
  • Ubiquitin-Like Containing PHD And RING Finger Domains 1-Binding Protein 1 3 4
  • ICBP90-Binding Protein 1 3 4
  • C6orf107 3 4
  • Chromosome 6 Open Reading Frame 107 2
  • UHRF1 (ICBP90) Binding Protein 1 3
  • ICBP90 Binding Protein 1 3
  • DJ349A12.1 3
  • ICBP90 3

External Ids for UHRF1BP1 Gene

Previous HGNC Symbols for UHRF1BP1 Gene

  • C6orf107

Previous GeneCards Identifiers for UHRF1BP1 Gene

  • GC06P034869
  • GC06P034763
  • GC06P034482
  • GC06P034866
  • GC06P035772
  • GC06P036302
  • GC06P037288
  • GC06P034962
  • GC06P035513

Summaries for UHRF1BP1 Gene

GeneCards Summary for UHRF1BP1 Gene

UHRF1BP1 (UHRF1 Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and histone deacetylase binding. An important paralog of this gene is UHRF1BP1L.

UniProtKB/Swiss-Prot for UHRF1BP1 Gene

  • May act as a negative regulator of cell growth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UHRF1BP1 Gene

Genomics for UHRF1BP1 Gene

Regulatory Elements for UHRF1BP1 Gene

Promoters for UHRF1BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UHRF1BP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UHRF1BP1 Gene

34,792,015 bp from pter
34,883,138 bp from pter
91,124 bases
Plus strand

Genomic View for UHRF1BP1 Gene

Genes around UHRF1BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UHRF1BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UHRF1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UHRF1BP1 Gene

Proteins for UHRF1BP1 Gene

  • Protein details for UHRF1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UHRF1-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9NXE0

    Protein attributes for UHRF1BP1 Gene

    1440 amino acids
    Molecular mass:
    159485 Da
    Quaternary structure:
    • Homodimer (Potential). Interacts with UHRF1.
    • Sequence=BAA91074.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

neXtProt entry for UHRF1BP1 Gene

Proteomics data for UHRF1BP1 Gene at MOPED

Post-translational modifications for UHRF1BP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UHRF1BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UHRF1BP1 Gene

Domains & Families for UHRF1BP1 Gene

Protein Domains for UHRF1BP1 Gene


Suggested Antigen Peptide Sequences for UHRF1BP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UHRF1BP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for UHRF1BP1 Gene

Function for UHRF1BP1 Gene

Molecular function for UHRF1BP1 Gene

UniProtKB/Swiss-Prot Function:
May act as a negative regulator of cell growth.

Gene Ontology (GO) - Molecular Function for UHRF1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 15361834
GO:0042826 histone deacetylase binding IPI 15361834
genes like me logo Genes that share ontologies with UHRF1BP1: view
genes like me logo Genes that share phenotypes with UHRF1BP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UHRF1BP1 Gene

Localization for UHRF1BP1 Gene

Subcellular locations from

Jensen Localization Image for UHRF1BP1 Gene COMPARTMENTS Subcellular localization image for UHRF1BP1 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UHRF1BP1 Gene

Pathways & Interactions for UHRF1BP1 Gene

SuperPathways for UHRF1BP1 Gene

No Data Available

Interacting Proteins for UHRF1BP1 Gene

Gene Ontology (GO) - Biological Process for UHRF1BP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for UHRF1BP1 Gene

Drugs & Compounds for UHRF1BP1 Gene

No Compound Related Data Available

Transcripts for UHRF1BP1 Gene

Unigene Clusters for UHRF1BP1 Gene

UHRF1 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UHRF1BP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22

Relevant External Links for UHRF1BP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UHRF1BP1 Gene

mRNA expression in normal human tissues for UHRF1BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UHRF1BP1 Gene

This gene is overexpressed in Fetal testis (15.8), Placenta (14.0), and CD8 Tcells (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UHRF1BP1 Gene

SOURCE GeneReport for Unigene cluster for UHRF1BP1 Gene Hs.700656

genes like me logo Genes that share expression patterns with UHRF1BP1: view

Protein tissue co-expression partners for UHRF1BP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UHRF1BP1 Gene

Orthologs for UHRF1BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UHRF1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UHRF1BP1 35
  • 88.92 (n)
  • 88.6 (a)
  • 88 (a)
(Canis familiaris)
Mammalia UHRF1BP1 35
  • 90.2 (n)
  • 90.69 (a)
  • 91 (a)
(Mus musculus)
Mammalia Uhrf1bp1 35
  • 83.33 (n)
  • 84.03 (a)
Uhrf1bp1 16
Uhrf1bp1 36
  • 84 (a)
(Pan troglodytes)
Mammalia UHRF1BP1 35
  • 99.58 (n)
  • 99.51 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Uhrf1bp1 35
  • 83.44 (n)
  • 84.63 (a)
(Monodelphis domestica)
Mammalia UHRF1BP1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia UHRF1BP1 36
  • 71 (a)
(Gallus gallus)
Aves UHRF1BP1 35
  • 67.93 (n)
  • 65.28 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia UHRF1BP1 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4421 35
(Danio rerio)
Actinopterygii uhrf1bp1 35
  • 57.22 (n)
  • 51.79 (a)
uhrf1bp1 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34126 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea C44H4.4 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for UHRF1BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UHRF1BP1 Gene

Gene Tree for UHRF1BP1 (if available)
Gene Tree for UHRF1BP1 (if available)

Paralogs for UHRF1BP1 Gene

Paralogs for UHRF1BP1 Gene

(3) SIMAP similar genes for UHRF1BP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UHRF1BP1: view

Variants for UHRF1BP1 Gene

Sequence variations from dbSNP and Humsavar for UHRF1BP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs16894945 - 34,856,330(+) AGCAA(A/C)ATGGA reference, missense
rs11755393 - 34,856,859(+) CTTTC(A/G)GCCTC reference, missense
rs3734265 - 34,858,916(-) ATCCT(C/T)AGTCA reference, missense
rs9469913 - 34,859,308(+) ACCCA(A/T)GCCTC reference, missense
rs13205210 - 34,864,079(+) CTCCA(C/T)GAAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UHRF1BP1 Gene

Variant ID Type Subtype PubMed ID
dgv6831n71 CNV Gain 21882294
nsv885795 CNV Loss 21882294
nsv462905 CNV Gain 19166990
nsv885796 CNV Gain 21882294
nsv885797 CNV Gain 21882294
esv2667103 CNV Deletion 23128226
nsv508402 CNV Loss 20534489

Variation tolerance for UHRF1BP1 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.37; 97.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UHRF1BP1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UHRF1BP1 Gene

Disorders for UHRF1BP1 Gene

Relevant External Links for UHRF1BP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UHRF1BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UHRF1BP1 Gene

Publications for UHRF1BP1 Gene

  1. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. (PMID: 19838195) Gateva V. … Graham R.R. (Nat. Genet. 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PMID: 23273568) Yang W. … Lau Y.L. (Am. J. Hum. Genet. 2013) 3
  4. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PMID: 23449627) Cousminer D.L. … WidAcn E. (Hum. Mol. Genet. 2013) 3
  5. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. (PMID: 23740937) Martin J.E. … Martin J. (Hum. Mol. Genet. 2013) 3

Products for UHRF1BP1 Gene

Sources for UHRF1BP1 Gene

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