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Aliases for UHRF1BP1 Gene

Aliases for UHRF1BP1 Gene

  • UHRF1 Binding Protein 1 2 3
  • Ubiquitin-Like Containing PHD And RING Finger Domains 1-Binding Protein 1 3 4
  • ICBP90-Binding Protein 1 3 4
  • C6orf107 3 4
  • Chromosome 6 Open Reading Frame 107 2
  • UHRF1 (ICBP90) Binding Protein 1 3
  • ICBP90 Binding Protein 1 3
  • UHRF1-Binding Protein 1 3
  • DJ349A12.1 3
  • ICBP90 3

External Ids for UHRF1BP1 Gene

Previous Symbols for UHRF1BP1 Gene

  • C6orf107

Summaries for UHRF1BP1 Gene

GeneCards Summary for UHRF1BP1 Gene

UHRF1BP1 (UHRF1 Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and histone deacetylase binding. An important paralog of this gene is UHRF1BP1L.

UniProtKB/Swiss-Prot for UHRF1BP1 Gene

  • May act as a negative regulator of cell growth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UHRF1BP1 Gene

Genomics for UHRF1BP1 Gene

Genomic Location for UHRF1BP1 Gene

Start:
34,792,015 bp from pter
End:
34,883,138 bp from pter
Size:
91,124 bases
Orientation:
Plus strand

Genomic View for UHRF1BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UHRF1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UHRF1BP1 Gene

Regulatory Elements for UHRF1BP1 Gene

Proteins for UHRF1BP1 Gene

  • Protein details for UHRF1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6BDS2-URFB1_HUMAN
    Recommended name:
    UHRF1-binding protein 1
    Protein Accession:
    Q6BDS2
    Secondary Accessions:
    • Q9NXE0

    Protein attributes for UHRF1BP1 Gene

    Size:
    1440 amino acids
    Molecular mass:
    159485 Da
    Quaternary structure:
    • Homodimer (Potential). Interacts with UHRF1.
    SequenceCaution:
    • Sequence=BAA91074.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

neXtProt entry for UHRF1BP1 Gene

Proteomics data for UHRF1BP1 Gene at MOPED

Post-translational modifications for UHRF1BP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UHRF1BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UHRF1BP1 Gene

Domains for UHRF1BP1 Gene

Protein Domains for UHRF1BP1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with UHRF1BP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for UHRF1BP1 Gene

Function for UHRF1BP1 Gene

Molecular function for UHRF1BP1 Gene

UniProtKB/Swiss-Prot Function: May act as a negative regulator of cell growth.

Gene Ontology (GO) - Molecular Function for UHRF1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15361834
GO:0042802 identical protein binding IPI 15361834
GO:0042826 histone deacetylase binding IPI 15361834
genes like me logo Genes that share ontologies with UHRF1BP1: view

Phenotypes for UHRF1BP1 Gene

GenomeRNAi human phenotypes for UHRF1BP1:
genes like me logo Genes that share phenotypes with UHRF1BP1: view

miRNA for UHRF1BP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UHRF1BP1 Gene

Localization for UHRF1BP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UHRF1BP1 Gene COMPARTMENTS Subcellular localization image for UHRF1BP1 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for UHRF1BP1 Gene

Pathways for UHRF1BP1 Gene

SuperPathways for UHRF1BP1 Gene

No Data Available

Interacting Proteins for UHRF1BP1 Gene

Gene Ontology (GO) - Biological Process for UHRF1BP1 Gene

None

No data available for Pathways by source for UHRF1BP1 Gene

Transcripts for UHRF1BP1 Gene

Unigene Clusters for UHRF1BP1 Gene

UHRF1 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UHRF1BP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for UHRF1BP1 Gene

GeneLoc Exon Structure for
UHRF1BP1
ECgene alternative splicing isoforms for
UHRF1BP1

Expression for UHRF1BP1 Gene

mRNA expression in normal human tissues for UHRF1BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UHRF1BP1 Gene

SOURCE GeneReport for Unigene cluster for UHRF1BP1 Gene Hs.700656

genes like me logo Genes that share expressions with UHRF1BP1: view

Orthologs for UHRF1BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UHRF1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UHRF1BP1 36
  • 99.58 (n)
  • 99.51 (a)
UHRF1BP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UHRF1BP1 36
  • 88.92 (n)
  • 88.6 (a)
UHRF1BP1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UHRF1BP1 36
  • 90.2 (n)
  • 90.69 (a)
UHRF1BP1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uhrf1bp1 36
  • 83.33 (n)
  • 84.03 (a)
Uhrf1bp1 16
Uhrf1bp1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UHRF1BP1 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UHRF1BP1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uhrf1bp1 36
  • 83.44 (n)
  • 84.63 (a)
chicken
(Gallus gallus)
Aves UHRF1BP1 36
  • 67.93 (n)
  • 65.28 (a)
UHRF1BP1 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UHRF1BP1 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4421 36
zebrafish
(Danio rerio)
Actinopterygii uhrf1bp1 36
  • 57.22 (n)
  • 51.79 (a)
uhrf1bp1 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34126 37
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44H4.4 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
OneToMany
Species with no ortholog for UHRF1BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UHRF1BP1 Gene

ENSEMBL:
Gene Tree for UHRF1BP1 (if available)
TreeFam:
Gene Tree for UHRF1BP1 (if available)

Paralogs for UHRF1BP1 Gene

Paralogs for UHRF1BP1 Gene

Selected SIMAP similar genes for UHRF1BP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UHRF1BP1: view

Variants for UHRF1BP1 Gene

Sequence variations from dbSNP and Humsavar for UHRF1BP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs912717 -- 34,820,790(-) cctat(A/G)gtccc intron-variant
rs998278 -- 34,797,807(-) atatg(C/T)acctc intron-variant
rs1018622 -- 34,820,454(-) TAAAT(A/G)AAAAG intron-variant
rs1045526 -- 34,843,457(-) aaaaa(A/G)aaaaa intron-variant
rs1125340 -- 34,818,631(-) CAAGT(C/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UHRF1BP1 Gene

Variant ID Type Subtype PubMed ID
dgv6831n71 CNV Gain 21882294
nsv885795 CNV Loss 21882294
nsv462905 CNV Gain 19166990
nsv885796 CNV Gain 21882294
nsv885797 CNV Gain 21882294
esv2667103 CNV Deletion 23128226
nsv508402 CNV Loss 20534489

Relevant External Links for UHRF1BP1 Gene

HapMap Linkage Disequilibrium report
UHRF1BP1
Human Gene Mutation Database (HGMD)
UHRF1BP1

Disorders for UHRF1BP1 Gene

Relevant External Links for UHRF1BP1

Genetic Association Database (GAD)
UHRF1BP1
Human Genome Epidemiology (HuGE) Navigator
UHRF1BP1
genes like me logo Genes that share disorders with UHRF1BP1: view

No data available for UniProtKB/Swiss-Prot for UHRF1BP1 Gene

Publications for UHRF1BP1 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. (PMID: 15361834) Unoki M. … Nakamura Y. (Oncogene 2004) 3 4
  4. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. (PMID: 19838195) Gateva V. … Graham R.R. (Nat. Genet. 2009) 3 49
  5. Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. (PMID: 21068098) Orozco G. … Barton A. (Ann. Rheum. Dis. 2011) 3

Products for UHRF1BP1 Gene

Sources for UHRF1BP1 Gene

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