Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UHRF1 Gene

protein-coding   GIFtS: 52
GCID: GC19P004910

ubiquitin-like with PHD and ring finger domains 1
 Explore 6 diseases affiliated with
UHRF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UHRF1    

Aliases
for UHRF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin-Like With PHD And Ring Finger Domains 11 2     RING Finger Protein 1062 3
ICBP901 2 3 5     NP953 5
RNF1061 2 3     FLJ219251
Np951 2     E3 Ubiquitin-Protein Ligase UHRF12
Inverted CCAAT Box-Binding Protein Of 90 KDa2 3     HNP951
Nuclear Protein 952 3     HuNp953
Nuclear Zinc Finger Protein Np952 3     Ubiquitin-Like, Containing PHD And RING Finger Domains, 12
Transcription Factor ICBP902 3     EC 6.3.2.-3
Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 12 3     HuNp953
Ubiquitin-Like-Containing PHD And RING Finger Domains Protein 12 3     HNp951
HUHRF11     EC 6.3.28

External Ids:    HGNC: 125561   Entrez Gene: 291282   Ensembl: ENSG000000340637   OMIM: 6079905   UniProtKB: Q96T883   

Export aliases for UHRF1 gene to outside databases

Previous GC identifers: GC19P005001 GC19P004849 GC19P004860 GC19P004861 GC19P004671


Summaries
for UHRF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UHRF1:
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA
sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and
continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating
topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UHRF1_HUMAN, Q96T88
Function: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin
modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and
recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA
replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin
modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3
trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin
proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this
chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by
impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the
ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase
activity is related to its role in chromatin in vivo. May be involved in DNA repair

Gene Wiki entry for UHRF1


Genomic Views
for UHRF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UHRF1 gene promoter:
         Egr-3   MZF-1   PPAR-gamma1   AML1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): UHRF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UHRF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UHRF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

UHRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UHRF1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004910:  view genomic region     (about GC identifiers)

Start:
 4,903,092 bp from pter      End:
 4,962,165 bp from pter
Size:
 59,074 bases      Orientation:
 plus strand

Proteins
for UHRF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UHRF1_HUMAN, Q96T88 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase UHRF1  
Size: 793 amino acids; 89814 Da
Subunit: Interacts with DNMT3A and DNMT3B (By similarity). Interacts with DNMT1; the interaction is direct. Interacts
with USP7; leading to its deubiquitination. Interacts with histone H3. Interacts with HDAC1, but not with HDAC2.
Interacts with UHRF1BP1. Interacts with PML. Interacts with EHMT2. Binds hemimethylated CpG containing
oligonucleotides
Subcellular location: Nucleus. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also
localizes to euchromatic regions
Developmental stage: Expressed in fetal thymus, liver and kidney
Sequence caution: Sequence=BAB15177.1; Type=Erroneous initiation;
6/22 PDB 3D structures from and Proteopedia for UHRF1 (see all 22):
2FAZ (3D)        2L3R (3D)        2LGG (3D)        2LGK (3D)        2LGL (3D)        2PB7 (3D)    
Secondary accessions: A0JBR2 A8K024 B2RBA9 Q2HIX7 Q8J022 Q9H6S6 Q9P115 Q9P1U7
Alternative splicing: 2 isoforms:  Q96T88-1   Q96T88-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UHRF1: NX_Q96T88

Post-translational modifications:

  • Phosphorylation at Ser-298 of the linker region decreases the binding to H3K9me3. Phosphorylation at Ser-639 by CDK1
    • during M phase impairs interaction with USP7, preventing deubiquitination and leading to degradation by the proteasome1
  • Ubiquitinated; which leads to proteasomal degradation. Autoubiquitinated; interaction with USP7 leads to
    • deubiquitination and prevents degradation. Ubiquitination and degradation takes place during M phase, when
    phosphorylation at Ser-639 prevents intereaction with USP7 and subsequent deubiquitination. Polyubiquitination may be
    stimulated by DNA damage1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96T88

    • 4/8 DME Specific Peptides for UHRF1 (Q96T88) (see all 8)
     GVHRPHV  HNVCKDCL  QRLFYRGKQ  WRFRVQVSE 

    UHRF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001041666.1  NP_037414.3  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: UHRF1
    OriGene Protein Over-expression Lysate (see all 3): UHRF1
    OriGene Custom Protein Services for UHRF1 
    GenScript Custom Purified and Recombinant Proteins Services for UHRF1
    Novus Biologicals UHRF1 Protein
    Novus Biologicals UHRF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UHRF1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ISS--
    GO:0000791euchromatin IDA--
    GO:0000792heterochromatin IDA--
    GO:0005634nucleus IDA--
    GO:0005657replication fork IDA17673620


    UHRF1 for ontologies           About GeneDecksing



    UHRF1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of UHRF1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UHRF1 
    GenScript Custom Superior Antibodies Services for UHRF1
    Novus Biologicals UHRF1 Antibodies
    Search for Antibodies for UHRF1 at Abcam  
    Uscn Antibodies for UHRF1
    Search ThermoFisher Antibodies for UHRF1

    Assay Products for UHRF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UHRF1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for UHRF1

    Protein Domains /
    Families
    for UHRF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UHRF1 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR014722 Rib_L2_dom2
     IPR003105 SRA_YDG

    Graphical View of Domain Structure for InterPro Entry Q96T88

    ProtoNet protein and cluster: Q96T88

    2 Blocks protein families:
    IPB000626 Ubiquitin domain
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: UHRF1_HUMAN, Q96T88
    Domain: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the
    PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). The tudor-like
    regions simultaneously recognizes H3K9me3 through a conserved aromatic cage in the first tudor-like subdomain and
    unmodified H3K4 (H3K4me0) within a groove between the tandem subdomains (PubMed:21489993, PubMed:21777816 and
    PubMed:22100450). The linker region plays a role in the formation of a histone H3-binding hole between the reader
    modules formed by the tudor-like regions and the PHD-type zinc finger by making extended contacts with the tandem
    tudor-like regions (PubMed:22837395)
    Domain: The YDG domain (also named SRA domain) specifically recognizes and binds hemimethylated DNA at replication
    forks (DNA that is only methylated on the mother strand of replicating DNA) (PubMed:17673620). It contains a binding
    pocket that accommodates the 5-methylcytosine that is flipped out of the duplex DNA. 2 specialized loops reach through
    the resulting gap in the DNA from both the major and the minor grooves to read the other 3 bases of the CpG duplex.
    The major groove loop confers both specificity for the CpG dinucleotide and discrimination against methylation of
    deoxycytidine of the complementary strand (PubMed:18772889). The YDG domain also recognizes and binds
    5-hydroxymethylcytosine (5hmC) (PubMed:21731699)
    Domain: The RING finger is required for ubiquitin ligase activity (By similarity)
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 ubiquitin-like domain
    Similarity: Contains 1 YDG domain


    Function
    for UHRF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UHRF1_HUMAN, Q96T88
    Function: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin
    modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and
    recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA
    replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin
    modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3
    trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin
    proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this
    chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by
    impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the
    ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase
    activity is related to its role in chromatin in vivo. May be involved in DNA repair
    Induction: Up-regulated in proliferating cells, and down-regulated in quiescent cells. Down-regulated upon
    adriamycin-induced DNA damage, in a p53/TP53 and CDKN1A-dependent way. Induced by E2F1 transcription factor

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
    Products:            		miRTarBase miRNAs that target UHRF1:
    hsa-let-7b (MIRT001580), hsa-mir-1 (MIRT001324), hsa-mir-124 (MIRT002574)

    OriGene 3'-UTR Clone (see all 2): UHRF1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UHRF1
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate UHRF1 (see all 52):
    hsa-miR-579 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-188-5p hsa-let-7d hsa-miR-146a hsa-miR-346
    SwitchGear 3'UTR luciferase reporter plasmid: UHRF1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UHRF1 (see all 7)
    OriGene shRNA RFP: UHRF1
    OriGene siRNA: UHRF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UHRF1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UHRF1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): UHRF1 (NM_015054)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UHRF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for UHRF1
    Search LifeMap BioReagents cell lines for UHRF1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF1

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000987core promoter proximal region sequence-specific DNA binding IDA10646863
    GO:0003700sequence-specific DNA binding transcription factor activity TAS1868030
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding IPI15361834
    GO:0008270zinc ion binding IDA--


    UHRF1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UHRF1:
     Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-out Uhrf1tm1Hko for UHRF1
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Uhrf1):
     cellular  craniofacial  embryogenesis  growth/size  mortality/aging 
     nervous system  skeleton 

    UHRF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UHRF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: UHRF1_HUMAN, Q96T88
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UHRF1

    5/42 Interacting proteins for UHRF1 (Q96T881, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006281DNA repair IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation IEP15361834


    UHRF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UHRF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UHRF1
    Search CenterWatch for drugs/clinical trials and news about UHRF1 

    Transcripts
    for UHRF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UHRF1 gene (2 alternative transcripts): 
    NM_001048201.1  NM_013282.3  

    Unigene Cluster for UHRF1:

    Ubiquitin-like with PHD and ring finger domains 1
    Hs.108106  [show with all ESTs]
    Unigene Representative Sequence: AB177623
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592666 ENST00000591733 ENST00000587870 ENST00000587187 ENST00000591699
    ENST00000592200 ENST00000398240(uc002mbp.3) ENST00000262952(uc002mbo.3 uc010xik.2 uc010duf.3)
    ENST00000455180 ENST00000543616 ENST00000396708

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): UHRF1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UHRF1
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate UHRF1 (see all 52):
    hsa-miR-579 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-188-5p hsa-let-7d hsa-miR-146a hsa-miR-346
    SwitchGear 3'UTR luciferase reporter plasmid: UHRF1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UHRF1 (see all 7)
    OriGene shRNA RFP: UHRF1
    OriGene siRNA: UHRF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UHRF1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): UHRF1 (NM_015054)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UHRF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UHRF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UHRF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UHRF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UHRF1

    Additional cDNA sequence: 

    AB177623.1 AB177624.1 AF129507.1 AF274048.1 AK025578.1 AK074377.1 AK098038.1 AK289389.1 
    AK303361.1 AK307239.1 AK314579.1 BC039136.1 BC046179.1 BC113875.1 BC137009.1 BC137015.1 
    EF560733.1 

    9 DOTS entries:

    DT.215306  DT.99931382  DT.87003366  DT.121120124  DT.121120047  DT.100780588  DT.92058772  DT.102822372 
    DT.121471213 

    24/140 AceView cDNA sequences (see all 140):

    BX281402 AA776570 AW298508 AA744240 BM457271 AI939609 AI630555 AA827671 
    AA306523 AA330245 CD624706 AA927056 BF515337 AW971840 AI479687 BM818106 
    AA380437 AA811217 AA282079 AI084125 AA598940 BM557599 BG289630 CD624703 

    GeneLoc Exon Structure


    Expression
    for UHRF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UHRF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGTGGCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UHRF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Primordial germ cell-like cells (Reconstitution of mo...)

    See UHRF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UHRF1

    SOURCE GeneReport for Unigene cluster: Hs.108106

    UniProtKB/Swiss-Prot: UHRF1_HUMAN, Q96T88
    Tissue specificity: Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer

        SABiosciences Custom PCR Arrays for UHRF1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UHRF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UHRF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UHRF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UHRF1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF1

    Orthologs
    for UHRF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UHRF1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Uhrf11 , 5 ubiquitin-like, containing PHD and RING finger domains, 1 less1, 5 75.64(n)1
    76.33(a)1    		   17 (29.26 cM)5
    181401  NM_001111078.11  NP_001104548.11 
     563033215 
    chicken
    (Gallus gallus)    		 Aves UHRF11 ubiquitin-like with PHD and ring finger domains 1 68.74(n)
    76.52(a)    		   420154  XM_418269.3  XP_418269.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.151172 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_037414.2 (H.sapiens) ubiquitin-like, containing PHD and RING finger domains, 1; transcription factor ICBP90 [Homo sapiens] less 73.02(n)    BJ097292.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb97f092 Danio rerio cDNA clone MGC63539 IMAGE3815965, complete cds less 77.92(n)    BC058055.1 


    ENSEMBL Gene Tree for UHRF1 (if available)
    TreeFam Gene Tree for UHRF1 (if available) 

    Paralogs
    for UHRF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UHRF1 gene
    1 SIMAP similar gene for UHRF1 using alignment to 2 protein entries:     UHRF1_HUMAN (see all proteins):
    UHRF2

    UHRF1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UHRF1
    PGOHUM00000239702


    Genomic Variants
    for UHRF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1125 NCBI SNPs in UHRF1 are shown (see all 1125)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1839046911,2
    		--4907577(+) ACGCCC/TGGCCC 1 -- us2k10--------
    rs1400922501,2
    		--4907644(+) CAGGGA/CGGGTT 1 -- us2k10--------
    rs1887943931,2
    		--4907650(+) GGGTTC/TTAGGA 1 -- us2k10--------
    rs1436789881,2
    		--4907787(+) TGGCGC/TGATCT 1 -- us2k10--------
    rs1930580061,2
    		--4907828(+) CAAGCA/GATTCT 1 -- us2k10--------
    rs1829408521,2
    		--4908013(+) GCCAAC/TGCGCC 1 -- us2k10--------
    rs48076631,2
    		C,F,A,--4908015(+) CAACGT/CGCCCG 1 -- us2k13Minor allele frequency- C:0.44NA WA 122
    rs1463144941,2
    		--4908079(+) TTTGAC/TCTTTT 1 -- us2k10--------
    rs48076641,2
    		C,F,A,H,--4908093(+) TCCCTT/GTTTCA 1 -- us2k1 trp318Minor allele frequency- G:0.21NS EA NA WA 2338
    rs1155738751,2
    		F,--4908196(+) GTTGCA/GAAGTC 1 -- us2k11Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for UHRF1 (4903092 - 4962165 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for UHRF1
         1 Indel: 40255

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UHRF1
    DNA2.0 Custom Variant and Variant Library Synthesis for UHRF1

    Disorders / Diseases
    for UHRF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UHRF1 for disorders           About GeneDecksing

    OMIM gene information: 607990    OMIM disorders: --

    UniProtKB/Swiss-Prot: UHRF1_HUMAN, Q96T88
  • Note=Defects in UHRF1 may be a cause of cancers. Overexpressed in many different forms of human cancers,
    • including bladder, breast, cervical, colorectal and prostate cancers, as well as pancreatic adenocarcinomas,
    rhabdomyosarcomas and gliomas. Plays an important role in the correlation of histone modification and gene silencing
    in cancer progression. Expression is associated with a poor prognosis in patients with various cancers, suggesting
    that it participates in cancer progression

    6 diseases for UHRF1:    About MalaCards
    retinoblastoma    sporadic breast cancer    breast cancer    cervical cancer
    cervicitis    lung cancer

    3 Novoseek disease relationships for UHRF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 34.7 18 12838312 (6), 17934516 (1), 10646863 (1), 11290415 (1) (see all 7)
    breast carcinoma 27.5 2 12838312 (1), 10646863 (1)
    leukemia 9.32 1 11290415 (1)

    Human Genome Epidemiology (HuGE) Navigator: UHRF1 (2 documents)

    Export disorders for UHRF1 gene to outside databases

    Publications
    for UHRF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UHRF1 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with UHRF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIa expression. (PubMed id 10646863)1, 2, 3, 9 Hopfner R.... Bronner C. (2000)
    2. UHRF1 is a novel molecular marker for diagnosis and t he prognosis of bladder cancer. (PubMed id 19491893)1, 2, 9 Unoki M....Hamamoto R. (2009)
    3. UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. (PubMed id 19056828)1, 2, 9 Kim J.K....Pradhan S. (2009)
    4. ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. (PubMed id 12838312)1, 2, 9 Mousli M.... Bronner C. (2003)
    5. Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression. (PubMed id 15178447)1, 2, 9 Trotzier M.-A.... Mousli M. (2004)
    6. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. (PubMed id 17673620)1, 2, 9 Bostick M....Jacobsen S.E. (2007)
    7. Isolation and Characterization of a Novel Human Radiosusceptibility Gene, NP95. (PubMed id 17067204)1, 2, 9 Muto M.... Tatsumi K. (2006)
    8. Structure and hemimethylated CpG binding of the SRA d omain from human UHRF1. (PubMed id 18945682)1, 2, 9 Qian C....Zhou M.M. (2008)
    9. Recognition of modification status on a histone H3 tai l by linked histone reader modules of the epigenetic regulator UHRF1. (PubMed id 22837395)1, 2 Arita K....Shirakawa M. (2012)
    10. The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. (PubMed id 22945642)1, 2 Guan D.... Kao H.Y. (2012)

    External Searches for UHRF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UHRF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29128 HGNC: 12556 AceView: UHRF1 Ensembl:ENSG00000034063 euGenes: HUgn29128
    ECgene: UHRF1 H-InvDB: UHRF1

    Other Databases showing UHRF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UHRF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UHRF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UHRF1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/uhrf1/

    Intellectual Property
    for UHRF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UHRF1 gene:
    Search GeneIP for patents involving UHRF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for UHRF1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UHRF1
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for UHRF1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UHRF1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UHRF1  
     OriGene Protein Over-expression Lysate for UHRF1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for UHRF1   OriGene 3'-UTR Clone for UHRF1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UHRF1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for UHRF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UHRF1   OriGene Custom Protein Services for UHRF1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UHRF1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UHRF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UHRF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UHRF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UHRF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UHRF1
     GenScript Custom Purified and Recombinant Proteins Services for UHRF1 GenScript cDNA clones with any tag delivered in your preferred vector for UHRF1
     GenScript Custom Assay Services for UHRF1 GenScript Custom Superior Antibodies Services for UHRF1
     GenScript Custom overexpressing Cell Line Services for UHRF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UHRF1 promoter
     Search Chromatin IP Primers for UHRF1
     RT2 qPCR Primer Assay in human, mouse, rat UHRF1
     GNC Network for UHRF1
     SABiosciences Custom PCR Arrays for UHRF1
     Search Tocris compounds for UHRF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UHRF1 antibodies
     UHRF1 proteins
     UHRF1 lysates
     Search for Antibodies for UHRF1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for UHRF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     UHRF1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for UHRF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHRF1
     SwitchGear 3'UTR luciferase reporter plasmids for UHRF1
     SwitchGear Promoter luciferase reporter plasmids for UHRF1
     Search ThermoFisher Antibodies for UHRF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHRF1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      UHRF1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4