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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UHMK1 Gene

protein-coding   GIFtS: 59
GCID: GC01P162467

U2AF Homology Motif (UHM) Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
U2AF Homology Motif (UHM) Kinase 11 2     KIS Protein Kinase2
KIS2 3 5     Serine/Threonine-Protein Kinase Kist2
KIST2 3     EC 2.7.11.13
P-CIP22 3     Kinase Interacting With Stathmin3
PAM COOH-Terminal Interactor Protein 22 3     U2AF Homology Motif Kinase 13
Kinase Interacting With Leukemia-Associated Gene (Stathmin)2     

External Ids:    HGNC: 196831   Entrez Gene: 1279332   Ensembl: ENSG000001523327   OMIM: 6088495   UniProtKB: Q8TAS13   

Export aliases for UHMK1 gene to outside databases

Previous GC identifers: GC01P159200 GC01P160734 GC01P133712


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UHMK1 Gene:
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by
phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and
degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been
associated with schizophrenia. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
May 2010)

GeneCards Summary for UHMK1 Gene: 
UHMK1 (U2AF homology motif (UHM) kinase 1) is a protein-coding gene. Diseases associated with UHMK1 include dracunculiasis, and schizophrenia. GO annotations related to this gene include RNA binding and enzyme binding. An important paralog of this gene is U2AF2.

UniProtKB/Swiss-Prot: UHMK1_HUMAN, Q8TAS1
Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and
cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity)

Gene Wiki entry for UHMK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UHMK1 gene promoter:
         RP58   Pbx1a   p53   FOXC1   CBF-A   CBF-B   FOXO4   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UHMK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UHMK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UHMK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1

UHMK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UHMK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P162467:  view genomic region     (about GC identifiers)

Start:
162,466,964 bp from pter      End:
162,499,419 bp from pter
Size:
32,456 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UHMK1_HUMAN, Q8TAS1 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Kist  
Size: 419 amino acids; 46546 Da
Subunit: Interacts with stathmin and CDKN1B/p27Kip1 (By similarity). Interacts with PAM
Subcellular location: Nucleus
Developmental stage: Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at
G1 phase (at protein level)
Secondary accessions: A8K8K4 G3V1M1 Q96C22
Alternative splicing: 3 isoforms:  Q8TAS1-1   Q8TAS1-2   Q8TAS1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UHMK1: NX_Q8TAS1

Explore proteomics data for UHMK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TAS1

  • UHMK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UHMK1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171692.1  NP_653225.2  NP_787062.1  

    ENSEMBL proteins: 
     ENSP00000420270   ENSP00000441226   ENSP00000446416  

    Human Recombinant Protein Products for UHMK1: 
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    Novus Biologicals UHMK1 Proteins
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for UHMK1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12093740
    GO:0005737cytoplasm ----
    GO:0030424axon ISS--
    GO:0032839dendrite cytoplasm ISS--
    GO:0071598neuronal ribonucleoprotein granule ISS--

    UHMK1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: U2AF homology motif (UHM) kinase 1 
    Other-unique family

    4 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q8TAS1

    ProtoNet protein and cluster: Q8TAS1

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: UHMK1_HUMAN, Q8TAS1
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    UHMK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UHMK1_HUMAN, Q8TAS1
    Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and
    cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12093740
    GO:0004713protein tyrosine kinase activity ----
         
    UHMK1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for UHMK1:
     Decreased substrate adherent c  Decreased viability  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased cell death in breast  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Uhmk1):
     cardiovascular system  cellular  homeostasis/metabolism 

    UHMK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Uhmk1tm1Enbl for UHMK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UHMK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UHMK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UHMK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UHMK1 

    miRNA
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    miRTarBase miRNAs that target UHMK1:
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    8/134 QIAGEN miScript miRNA Assays for microRNAs that regulate UHMK1 (see all 134):
    hsa-miR-100* hsa-miR-3938 hsa-miR-520f hsa-miR-106a hsa-miR-1245 hsa-miR-4305 hsa-miR-3653 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidUHMK1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHMK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UHMK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/18 Interacting proteins for UHMK1 (Q8TAS12, 3 ENSP000004202704) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110851 I2D: score=3 STRING: ENSP00000361423
    PAMP190213, ENSP000003061004I2D: score=2 STRING: ENSP00000306100
    STMN1P169493, ENSP000004104524I2D: score=1 STRING: ENSP00000410452
    TGFBR1P368973I2D: score=2 
    ACVR1Q047713I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007050cell cycle arrest IMP12093740
    GO:0018105peptidyl-serine phosphorylation ISS--
    GO:0031175neuron projection development ISS--
    GO:0045948positive regulation of translational initiation ISS--

    UHMK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UHMK1

    2 HMDB Compounds for UHMK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about UHMK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UHMK1 gene (3 alternative transcripts): 
    NM_001184763.1  NM_144624.2  NM_175866.4  

    Unigene Cluster for UHMK1:

    U2AF homology motif (UHM) kinase 1
    Hs.127310  [show with all ESTs]
    Unigene Representative Sequence: NM_175866
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489294(uc001gcd.3 uc001gcc.2) ENST00000282169 ENST00000545294
    ENST00000538489(uc009wuu.2)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UHMK1
    8/134 QIAGEN miScript miRNA Assays for microRNAs that regulate UHMK1 (see all 134):
    hsa-miR-100* hsa-miR-3938 hsa-miR-520f hsa-miR-106a hsa-miR-1245 hsa-miR-4305 hsa-miR-3653 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidUHMK1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): UHMK1 (NM_175866)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UHMK1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UHMK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UHMK1

    Additional mRNA sequence: 

    AJ536197.1 AK026668.1 AK058195.1 AK292369.1 AL137257.1 BC001977.1 BC014917.1 BC026046.1 
    BC043436.2 

    13 DOTS entries:

    DT.445586  DT.210638  DT.100774200  DT.100774199  DT.97768341  DT.91764290  DT.102820450  DT.91694957 
    DT.95361925  DT.100795455  DT.100806356  DT.121421501  DT.121421503 

    24/385 AceView cDNA sequences (see all 385):

    BM460146 BE328788 AI370148 BC001977 AA261924 BM468107 AI568681 AW418912 
    BM470097 BF447861 CA431103 CB990192 BU154596 AW029519 BQ721861 AI637822 
    BX281211 AI141389 AW197076 AI571020 AI862794 BE895119 CA431112 BU902733 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UHMK1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:        -     -                                                   
    SP2:                                                                  
    SP3:                                                  -               


    ECgene alternative splicing isoforms for UHMK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UHMK1 expression in normal human tissues (normalized intensities)      UHMK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UHMK1 Expression
    About this image


    UHMK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Olfactory Bulb   
     
     Stomach (Gastrointestinal Tract)

    See UHMK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UHMK1

    SOURCE GeneReport for Unigene cluster: Hs.127310

    UniProtKB/Swiss-Prot: UHMK1_HUMAN, Q8TAS1
    Tissue specificity: Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral
    blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHMK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UHMK1 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uhmk11 , 5 U2AF homology motif (UHM) kinase 11, 5 93(n)1
    99.28(a)1
      1 (76.84 cM)5
    165891  NM_010633.31  NP_034763.31 
     1701934205 
    chicken
    (Gallus gallus)
    Aves UHMK11 U2AF homology motif (UHM) kinase 1 77.59(n)
    82.64(a)
      424369  XM_422213.3  XP_422213.3 
    lizard
    (Anolis carolinensis)
    Reptilia UHMK16
    UHMK16
    Uncharacterized protein
    77(a)
    45(a)
    1 ↔ 1
    possible ortholog
    AAWZ02038933(255-9356)
    GL343405.1(5208-24479)
    zebrafish
    (Danio rerio)
    Actinopterygii uhmk11 U2AF homology motif (UHM) kinase 1 70.12(n)
    74.75(a)
      767721  NM_001076659.1  NP_001070127.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sma-56
    Protein SMA-5, isoform c
    15(a)
    1 ↔ 1
    X(11997525-12005092)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMK16
    KDX16
    (see all 3)
    Middle sporulation-specific mitogen-activated prot...
    Protein kinase implicated in the Slt2p mitogen-act...
    (see all 3)
    20(a)
    19(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    XVI(666280-667446)
    XI(149386-150687)


    ENSEMBL Gene Tree for UHMK1 (if available)
    TreeFam Gene Tree for UHMK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UHMK1 gene
    U2AF22  
    1 SIMAP similar gene for UHMK1 using alignment to 1 protein entry:     UHMK1_HUMAN:
    DKFZp667I0511

    UHMK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/686 SNPs in UHMK1 are shown (see all 686)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500863171,2
    --162465045(+) TAACCA/GGGCAT 1 -- us2k10--------
    rs587830431,2
    C--162465056(+) GGTGGC/TGCATG 1 -- us2k10--------
    rs580249411,2
    C--162465103(+) GAATTC/GCTTGA 1 -- us2k10--------
    rs1435586691,2
    --162465152(+) CACTGC/GACTCC 1 -- us2k10--------
    rs2013454041,2
    --162465194(+) ACAAA-/CCAAAC 1 -- us2k10--------
    rs727057071,2
    C--162465196(+) CAAACA/CAACCA 1 -- us2k10--------
    rs1473561301,2
    C--162465197(+) AACCA-/AACC  
            
    ACCTA
    1 -- us2k10--------
    rs1832474551,2
    --162465281(+) AGAAAG/TAATTC 1 -- us2k10--------
    rs1380847161,2
    C--162465309(+) CAAGTC/TTATTA 1 -- us2k10--------
    rs1436040031,2
    C--162465374(+) CTGCTC/TGACTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UHMK1 (162466964 - 162499419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UHMK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv159160CNV Loss16902084
    nsv516482CNV Gain+Loss19592680
    dgv141e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608849    OMIM disorders: --

    4 diseases for UHMK1:    About MalaCards
    dracunculiasis    schizophrenia    leukemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for UHMK1:
    Schizophrenia

    UHMK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UHMK1
    Human Genome Epidemiology (HuGE) Navigator: UHMK1 (4 documents)

    Export disorders for UHMK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UHMK1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with UHMK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. (PubMed id 12782393)1, 2, 3, 9 Bieche I....Maucuer A. (2003)
    2. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. (PubMed id 12093740)1, 2, 3 Boehm M.... Nabel E.G. (2002)
    3. Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype. (PubMed id 19747464)1, 4, 9 Bristow G.C....Eastwood S.L. (2009)
    4. Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3. (PubMed id 18414510)1, 4, 9 Puri V....Gurling H. (2008)
    5. The CATS (FAM64A) protein is a substrate of the kinase interacting stathmin (KIS). (PubMed id 23419774)1, 2 Archangelo L.F.... Saad S.T. (2013)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. (PubMed id 10574929)1, 2 Caldwell B.D....Mains R.E. (1999)
    9. FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. (PubMed id 17984092)1, 9 Petrovic V....Tyner A.L. (2008)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 127933 HGNC: 19683 AceView: KIS Ensembl:ENSG00000152332 euGenes: HUgn127933
    ECgene: UHMK1 H-InvDB: UHMK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UHMK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UHMK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UHMK1 gene:
    Search GeneIP for patents involving UHMK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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