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Aliases for UHMK1 Gene

Aliases for UHMK1 Gene

  • U2AF Homology Motif (UHM) Kinase 1 2 3
  • KIS 3 4 6
  • PAM COOH-Terminal Interactor Protein 2 3 4
  • P-CIP2 3 4
  • KIST 3 4
  • Kinase Interacting With Leukemia-Associated Gene (Stathmin) 3
  • Serine/Threonine-Protein Kinase Kist 3
  • Kinase Interacting With Stathmin 4
  • U2AF Homology Motif Kinase 1 4
  • KIS Protein Kinase 3
  • EC 4

External Ids for UHMK1 Gene

Summaries for UHMK1 Gene

Entrez Gene Summary for UHMK1 Gene

  • The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for UHMK1 Gene

UHMK1 (U2AF Homology Motif (UHM) Kinase 1) is a Protein Coding gene. Diseases associated with UHMK1 include schizophrenia. Among its related pathways are GPCR Pathway. GO annotations related to this gene include RNA binding and enzyme binding. An important paralog of this gene is U2AF2.

UniProtKB/Swiss-Prot for UHMK1 Gene

  • Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).

Gene Wiki entry for UHMK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UHMK1 Gene

Genomics for UHMK1 Gene

Genomic Location for UHMK1 Gene

162,497,174 bp from pter
162,529,629 bp from pter
32,456 bases
Plus strand

Genomic View for UHMK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UHMK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UHMK1 Gene

Regulatory Elements for UHMK1 Gene

Proteins for UHMK1 Gene

  • Protein details for UHMK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase Kist
    Protein Accession:
    Secondary Accessions:
    • A8K8K4
    • G3V1M1
    • Q96C22

    Protein attributes for UHMK1 Gene

    419 amino acids
    Molecular mass:
    46546 Da
    Quaternary structure:
    • Interacts with stathmin and CDKN1B/p27Kip1 (By similarity). Interacts with PAM.

    Alternative splice isoforms for UHMK1 Gene


neXtProt entry for UHMK1 Gene

Proteomics data for UHMK1 Gene at MOPED

Post-translational modifications for UHMK1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys183, Lys383, and Lys397

Other Protein References for UHMK1 Gene

No data available for DME Specific Peptides for UHMK1 Gene

Domains for UHMK1 Gene

Gene Families for UHMK1 Gene

  • RBM :RNA binding motif (RRM) containing


  • Contains 1 protein kinase domain.:
    • Q8TAS1
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q8TAS1
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.:
    • Q8TAS1
genes like me logo Genes that share domains with UHMK1: view

Function for UHMK1 Gene

Molecular function for UHMK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).

Enzyme Numbers (IUBMB) for UHMK1 Gene

Gene Ontology (GO) - Molecular Function for UHMK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 12093740
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with UHMK1: view
genes like me logo Genes that share phenotypes with UHMK1: view

Animal Models for UHMK1 Gene

MGI Knock Outs for UHMK1:

No data available for Transcription Factor Targeting and HOMER Transcription for UHMK1 Gene

Localization for UHMK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UHMK1 Gene

Subcellular locations from

Jensen Localization Image for UHMK1 Gene COMPARTMENTS Subcellular localization image for UHMK1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UHMK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12093740
GO:0005737 cytoplasm --
GO:0030424 axon ISS --
GO:0032839 dendrite cytoplasm ISS --
GO:0071598 neuronal ribonucleoprotein granule ISS --
genes like me logo Genes that share ontologies with UHMK1: view

Pathways for UHMK1 Gene

SuperPathways for UHMK1 Gene

Superpath Contained pathways
1 GPCR Pathway
genes like me logo Genes that share pathways with UHMK1: view

Pathways by source for UHMK1 Gene

1 Qiagen pathway for UHMK1 Gene

Gene Ontology (GO) - Biological Process for UHMK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007050 cell cycle arrest IMP 12093740
GO:0018105 peptidyl-serine phosphorylation ISS --
GO:0031175 neuron projection development ISS --
GO:0045948 positive regulation of translational initiation ISS --
genes like me logo Genes that share ontologies with UHMK1: view

Compounds for UHMK1 Gene

(2) HMDB Compounds for UHMK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with UHMK1: view

Transcripts for UHMK1 Gene

Unigene Clusters for UHMK1 Gene

U2AF homology motif (UHM) kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UHMK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP3: -

Relevant External Links for UHMK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UHMK1 Gene

mRNA expression in normal human tissues for UHMK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UHMK1 Gene

SOURCE GeneReport for Unigene cluster for UHMK1 Gene Hs.127310

mRNA Expression by UniProt/SwissProt for UHMK1 Gene

Tissue specificity: Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
genes like me logo Genes that share expressions with UHMK1: view

Orthologs for UHMK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UHMK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UHMK1 36
  • 99.68 (n)
  • 99.76 (a)
UHMK1 37
  • 100 (a)
(Bos Taurus)
Mammalia UHMK1 36
  • 95.94 (n)
  • 99.76 (a)
UHMK1 37
  • 100 (a)
(Canis familiaris)
Mammalia UHMK1 36
  • 95.78 (n)
  • 99.76 (a)
UHMK1 37
  • 100 (a)
(Mus musculus)
Mammalia Uhmk1 36
  • 93 (n)
  • 99.28 (a)
Uhmk1 16
Uhmk1 37
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 90 (a)
-- 37
  • 94 (a)
(Rattus norvegicus)
Mammalia Uhmk1 36
  • 92.6 (n)
  • 99.28 (a)
(Gallus gallus)
Aves UHMK1 36
  • 81.62 (n)
  • 88.18 (a)
UHMK1 37
  • 88 (a)
(Anolis carolinensis)
Reptilia UHMK1 37
  • 77 (a)
(Danio rerio)
Actinopterygii uhmk1 36
  • 69.38 (n)
  • 73.58 (a)
uhmk1 37
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta LS2 37
  • 18 (a)
(Caenorhabditis elegans)
Secernentea uaf-1 37
  • 17 (a)
Species with no ortholog for UHMK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UHMK1 Gene

Gene Tree for UHMK1 (if available)
Gene Tree for UHMK1 (if available)

Paralogs for UHMK1 Gene

Paralogs for UHMK1 Gene

Selected SIMAP similar genes for UHMK1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UHMK1: view

Variants for UHMK1 Gene

Sequence variations from dbSNP and Humsavar for UHMK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9405 -- 162,523,875(+) ATTCT(G/T)AAAAG utr-variant-3-prime
rs189820 -- 162,522,056(-) AGATA(C/T)GGCTG intron-variant
rs242517 -- 162,503,512(+) aggct(C/G)aggca intron-variant
rs357038 -- 162,521,442(+) GATTC(A/G)TTATT intron-variant
rs357039 -- 162,520,185(+) cactg(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UHMK1 Gene

Variant ID Type Subtype PubMed ID
dgv141e1 CNV Complex 17122850
nsv516482 CNV Gain+Loss 19592680
nsv159160 CNV Loss 16902084

Relevant External Links for UHMK1 Gene

HapMap Linkage Disequilibrium report

Disorders for UHMK1 Gene

(1) MalaCards Diseases for UHMK1 Gene

Search for UHMK1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UHMK1 Gene

Relevant External Links for UHMK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UHMK1: view

No data available for UniProtKB/Swiss-Prot for UHMK1 Gene

Publications for UHMK1 Gene

  1. Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. (PMID: 12782393) Bieche I. … Maucuer A. (Brain Res. Mol. Brain Res. 2003) 2 3 4 23
  2. Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3. (PMID: 18414510) Puri V. … Gurling H. (Eur. J. Hum. Genet. 2008) 3 23 49
  3. Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype. (PMID: 19747464) Bristow G.C. … Eastwood S.L. (Brain Res. 2009) 3 23 49
  4. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. (PMID: 12093740) Boehm M. … Nabel E.G. (EMBO J. 2002) 2 3 4
  5. The CATS (FAM64A) protein is a substrate of the kinase interacting stathmin (KIS). (PMID: 23419774) Archangelo L.F. … Saad S.T. (Biochim. Biophys. Acta 2013) 3 4

Products for UHMK1 Gene

  • Addgene plasmids for UHMK1

Sources for UHMK1 Gene

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