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UHMK1 Gene

protein-coding   GIFtS: 59
GCID: GC01P162467

U2AF Homology Motif (UHM) Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
U2AF Homology Motif (UHM) Kinase 11 2     KIS Protein Kinase2
KIS2 3 5     Serine/Threonine-Protein Kinase Kist2
KIST2 3     EC 2.7.11.13
P-CIP22 3     Kinase Interacting With Stathmin3
PAM COOH-Terminal Interactor Protein 22 3     U2AF Homology Motif Kinase 13
Kinase Interacting With Leukemia-Associated Gene (Stathmin)2     

External Ids:    HGNC: 196831   Entrez Gene: 1279332   Ensembl: ENSG000001523327   OMIM: 6088495   UniProtKB: Q8TAS13   

Export aliases for UHMK1 gene to outside databases

Previous GC identifers: GC01P159200 GC01P160734 GC01P133712


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UHMK1 Gene:
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by
phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and
degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been
associated with schizophrenia. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
May 2010)

GeneCards Summary for UHMK1 Gene:
UHMK1 (U2AF homology motif (UHM) kinase 1) is a protein-coding gene. Diseases associated with UHMK1 include dracunculiasis, and schizophrenia. GO annotations related to this gene include RNA binding and enzyme binding. An important paralog of this gene is U2AF2.

UniProtKB/Swiss-Prot: UHMK1_HUMAN, Q8TAS1
Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and
cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity)

Gene Wiki entry for UHMK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the UHMK1 gene promoter:
         RP58   Pbx1a   p53   FOXC1   CBF-A   CBF-B   FOXO4   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UHMK1 promoter sequence
   Search Chromatin IP Primers for UHMK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UHMK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1

UHMK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UHMK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P162467:  view genomic region     (about GC identifiers)

Start:
162,466,964 bp from pter      End:
162,499,419 bp from pter
Size:
32,456 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UHMK1_HUMAN, Q8TAS1 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Kist  
Size: 419 amino acids; 46546 Da
Subunit: Interacts with stathmin and CDKN1B/p27Kip1 (By similarity). Interacts with PAM
Developmental stage: Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at
G1 phase (at protein level)
Secondary accessions: A8K8K4 G3V1M1 Q96C22
Alternative splicing: 3 isoforms:  Q8TAS1-1   Q8TAS1-2   Q8TAS1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UHMK1: NX_Q8TAS1

Explore proteomics data for UHMK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys183, Lys383, Lys397
  • Modification sites at PhosphoSitePlus

  • See UHMK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171692.1  NP_653225.2  NP_787062.1  

    ENSEMBL proteins: 
     ENSP00000420270   ENSP00000441226   ENSP00000446416  

    UHMK1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: U2AF homology motif (UHM) kinase 1
    Other-unique family

    4 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8TAS1

    ProtoNet protein and cluster: Q8TAS1

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: UHMK1_HUMAN, Q8TAS1
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    UHMK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UHMK1_HUMAN, Q8TAS1
    Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and
    cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12093740
    GO:0004713protein tyrosine kinase activity ----
         
    UHMK1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for UHMK1:
     Decreased substrate adherent c  Decreased viability  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased cell death in breast  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Uhmk1):
     cardiovascular system  cellular  homeostasis/metabolism 

    UHMK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Uhmk1tm1Enbl for UHMK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UHMK1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UHMK1

    miRNA
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    miRTarBase miRNAs that target UHMK1:
    hsa-mir-1 (MIRT002824), hsa-mir-9-5p (MIRT021385), hsa-mir-503-5p (MIRT041113), hsa-mir-148b-3p (MIRT019310), hsa-mir-335-5p (MIRT017233), hsa-mir-185-5p (MIRT045366), hsa-mir-124-3p (MIRT004890)

    Block miRNA regulation of human, mouse, rat UHMK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UHMK1 (see all 134):
    hsa-miR-100* hsa-miR-3938 hsa-miR-520f hsa-miR-106a hsa-miR-1245 hsa-miR-4305 hsa-miR-3653 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidUHMK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UHMK1
    Predesigned siRNA for gene silencing in human, mouse, rat UHMK1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): UHMK1 (NM_175866)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHMK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UHMK1_HUMAN, Q8TAS1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12093740
    GO:0005737cytoplasm ----
    GO:0030424axon ISS--
    GO:0032839dendrite cytoplasm ISS--
    GO:0071598neuronal ribonucleoprotein granule ISS--

    UHMK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for UHMK1
        Breast Cancer Regulation by Stathmin1


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UHMK1
    Interactions:

        GeneGlobe Interaction Network for UHMK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for UHMK1 (Q8TAS12, 3 ENSP000004202704) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110851 I2D: score=3 STRING: ENSP00000361423
    PAMP190213, ENSP000003061004I2D: score=2 STRING: ENSP00000306100
    STMN1P169493, ENSP000004104524I2D: score=1 STRING: ENSP00000410452
    TGFBR1P368973I2D: score=2 
    ACVR1Q047713I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007050cell cycle arrest IMP12093740
    GO:0018105peptidyl-serine phosphorylation ISS--
    GO:0031175neuron projection development ISS--
    GO:0045948positive regulation of translational initiation ISS--

    UHMK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UHMK1

    2 HMDB Compounds for UHMK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UHMK1 gene (3 alternative transcripts): 
    NM_001184763.1  NM_144624.2  NM_175866.4  

    Unigene Cluster for UHMK1:

    U2AF homology motif (UHM) kinase 1
    Hs.127310  [show with all ESTs]
    Unigene Representative Sequence: NM_175866
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489294(uc001gcd.3 uc001gcc.2) ENST00000282169 ENST00000545294
    ENST00000538489(uc009wuu.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat UHMK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UHMK1 (see all 134):
    hsa-miR-100* hsa-miR-3938 hsa-miR-520f hsa-miR-106a hsa-miR-1245 hsa-miR-4305 hsa-miR-3653 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidUHMK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UHMK1
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    GenScript: all cDNA clones in your preferred vector (see all 3): UHMK1 (NM_175866)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UHMK1
    Primer
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    OriGene qPCR primer pairs and template standards for UHMK1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UHMK1
      QuantiTect SYBR Green Assays in human, mouse, rat UHMK1
      QuantiFast Probe-based Assays in human, mouse, rat UHMK1

    Additional mRNA sequence: 

    AJ536197.1 AK026668.1 AK058195.1 AK292369.1 AL137257.1 BC001977.1 BC014917.1 BC026046.1 
    BC043436.2 

    13 DOTS entries:

    DT.445586  DT.210638  DT.100774200  DT.100774199  DT.97768341  DT.91764290  DT.102820450  DT.91694957 
    DT.95361925  DT.100795455  DT.100806356  DT.121421501  DT.121421503 

    Selected AceView cDNA sequences (see all 385):

    AI096425 BU154596 CA431103 AI249980 AI141389 AW073203 AI872182 C05255 
    BF447861 CB990192 AI347920 BU172162 BF589910 AA082212 W15270 AW418912 
    BG056501 BM929419 BQ959304 AI359727 AV659283 BE045615 BX281211 AK058195 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UHMK1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:        -     -                                                   
    SP2:                                                                  
    SP3:                                                  -               


    ECgene alternative splicing isoforms for UHMK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UHMK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UHMK1 Expression
    About this image


    UHMK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Olfactory Bulb   
     
     Stomach (Gastrointestinal Tract)
    UHMK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UHMK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127310

    UniProtKB/Swiss-Prot: UHMK1_HUMAN, Q8TAS1
    Tissue specificity: Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral
    blood leukocytes

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    QuantiFast Probe-based Assays in human, mouse, rat UHMK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UHMK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UHMK1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uhmk11 , 5 U2AF homology motif (UHM) kinase 11, 5 93(n)1
    99.28(a)1
      1 (76.84 cM)5
    165891  NM_010633.31  NP_034763.31 
     1701934205 
    chicken
    (Gallus gallus)
    Aves UHMK11 U2AF homology motif (UHM) kinase 1 81.62(n)
    88.18(a)
      424369  XM_422213.4  XP_422213.4 
    lizard
    (Anolis carolinensis)
    Reptilia UHMK16
    U2AF homology motif (UHM) kinase 1
    77(a)
    1 ↔ 1
    AAWZ02038933(255-9356)
    zebrafish
    (Danio rerio)
    Actinopterygii uhmk11 U2AF homology motif (UHM) kinase 1 69.38(n)
    73.58(a)
      767721  NM_001076659.1  NP_001070127.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LS26
    Large Subunit 2
    18(a)
    many ↔ many
    2R(19097648-19099062)
    worm
    (Caenorhabditis elegans)
    Secernentea uaf-16
    Protein UAF-1, isoform c
    17(a)
    1 ↔ 1
    III(1062792-1076555) WBGene00006697


    ENSEMBL Gene Tree for UHMK1 (if available)
    TreeFam Gene Tree for UHMK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UHMK1 gene
    U2AF22  
    1 SIMAP similar gene for UHMK1 using alignment to 1 protein entry:     UHMK1_HUMAN:
    DKFZp667I0511

    UHMK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UHMK1 (see all 686)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500863171,2
    --162465045(+) TAACCA/GGGCAT 1 -- us2k10--------
    rs587830431,2
    C--162465056(+) GGTGGC/TGCATG 1 -- us2k10--------
    rs580249411,2
    C--162465103(+) GAATTC/GCTTGA 1 -- us2k10--------
    rs1435586691,2
    --162465152(+) CACTGC/GACTCC 1 -- us2k10--------
    rs2013454041,2
    --162465194(+) ACAAA-/CCAAAC 1 -- us2k10--------
    rs727057071,2
    C--162465196(+) CAAACA/CAACCA 1 -- us2k10--------
    rs1473561301,2
    C--162465197(+) AACCA-/AACC  
            
    ACCTA
    1 -- us2k10--------
    rs1832474551,2
    --162465281(+) AGAAAG/TAATTC 1 -- us2k10--------
    rs1380847161,2
    C--162465309(+) CAAGTC/TTATTA 1 -- us2k10--------
    rs1436040031,2
    C--162465374(+) CTGCTC/TGACTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UHMK1 (162466964 - 162499419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UHMK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv159160CNV Loss16902084
    nsv516482CNV Gain+Loss19592680
    dgv141e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608849    OMIM disorders: --

    6 diseases for UHMK1:    
    About MalaCards
    dracunculiasis    schizophrenia    leukemia    bipolar disorder
    cerebritis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for UHMK1:
    Schizophrenia

    UHMK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UHMK1
    Human Genome Epidemiology (HuGE) Navigator: UHMK1 (4 documents)

    Export disorders for UHMK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for UHMK1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with UHMK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. (PubMed id 12782393)1, 2, 3, 9 Bieche I.... Maucuer A. (Brain Res. Mol. Brain Res. 2003)
    2. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. (PubMed id 12093740)1, 2, 3 Boehm M.... Nabel E.G. (EMBO J. 2002)
    3. Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype. (PubMed id 19747464)1, 4, 9 Bristow G.C....Eastwood S.L. (Brain Res. 2009)
    4. Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3. (PubMed id 18414510)1, 4, 9 Puri V....Gurling H. (Eur. J. Hum. Genet. 2008)
    5. The CATS (FAM64A) protein is a substrate of the kinase interacting stathmin (KIS). (PubMed id 23419774)1, 2 Archangelo L.F.... Saad S.T. (Biochim. Biophys. Acta 2013)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha- amidating monooxygenase. (PubMed id 10574929)1, 2 Caldwell B.D....Mains R.E. (J. Biol. Chem. 1999)
    9. FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. (PubMed id 17984092)1, 9 Petrovic V....Tyner A.L. (J. Biol. Chem. 2008)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 127933 HGNC: 19683 AceView: KIS Ensembl:ENSG00000152332 euGenes: HUgn127933
    ECgene: UHMK1 H-InvDB: UHMK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UHMK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UHMK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UHMK1 gene:
    Search GeneIP for patents involving UHMK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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