Aliases for UHMK1 Gene
External Ids for UHMK1 Gene
Previous GeneCards Identifiers for UHMK1 Gene
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for UHMK1 Gene
UHMK1 (U2AF Homology Motif Kinase 1) is a Protein Coding gene. Diseases associated with UHMK1 include Median Arcuate Ligament Syndrome and Dracunculiasis. Among its related pathways are GPCR Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is U2AF2.
UniProtKB/Swiss-Prot for UHMK1 Gene
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).