Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UGT8 Gene

protein-coding   GIFtS: 64
GCID: GC04P115519

UDP Glycosyltransferase 8

(Previous name: UDP-galactose ceramide galactosyltransferase)
(Previous symbol: CGT)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
UDP Glycosyltransferase 81 2     UGT42 3
CGT1 2 3 5     UDP-Galactose-Ceramide Galactosyltransferase2 3
UDP-Galactose Ceramide Galactosyltransferase1 2     Uridine Diphosphate Glycosyltransferase 82
2-Hydroxyacylsphingosine 1-Beta-Galactosyltransferase1 2     EC 2.4.1.453
Ceramide UDP-Galactosyltransferase2 3     EC 2.4.18
Cerebroside Synthase2 3     

External Ids:    HGNC: 125551   Entrez Gene: 73682   Ensembl: ENSG000001746077   OMIM: 6012915   UniProtKB: Q168803   

Export aliases for UGT8 gene to outside databases

Previous GC identifers: GC04P115964 GC04P115801 GC04P115978 GC04P116002 GC04P115877 GC04P115739 GC04P111253


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UGT8 Gene:
The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of
galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant
sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for UGT8 Gene:
UGT8 (UDP glycosyltransferase 8) is a protein-coding gene. Diseases associated with UGT8 include acid sphingomyelinase deficiency, and metachromatic leukodystrophy. GO annotations related to this gene include UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity and 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: CGT_HUMAN, Q16880
Function: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of
galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and
peripheral nervous system

Gene Wiki entry for UGT8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UGT8 gene promoter:
         Nkx3-1   ER-alpha   Nkx3-1 v4   HOXA3   MyoD   POU2F1   Nkx6-1   POU2F1a   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGT8 promoter sequence
   Search Chromatin IP Primers for UGT8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

UGT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P115519:  view genomic region     (about GC identifiers)

Start:
115,519,611 bp from pter      End:
115,599,380 bp from pter
Size:
79,770 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CGT_HUMAN, Q16880 (See protein sequence)
Recommended Name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor  
Size: 541 amino acids; 61438 Da
Secondary accessions: B3KXU7 O00196

Explore the universe of human proteins at neXtProt for UGT8: NX_Q16880

Explore proteomics data for UGT8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn78, Asn333, Asn442
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for UGT8 (Q16880)
     PQKVIWR  SHGGLNS 


    See UGT8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121646.1  NP_003351.2  

    ENSEMBL proteins: 
     ENSP00000311648   ENSP00000421446   ENSP00000378019  

    UGT8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UGT8
    GenScript Custom Purified and Recombinant Proteins Services for UGT8
    Novus Biologicals UGT8 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UGT8

    UGT8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UGT8
    OriGene Custom Antibody Services for UGT8
    Novus Biologicals UGT8 Antibodies
    Abcam antibodies for UGT8
    Cloud-Clone Corp. Antibodies for UGT8
    Search ThermoFisher Antibodies for UGT8
    LSBio Antibodies in human, mouse, rat for UGT8

    UGT8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UGT8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UGT8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UGT8
    Cloud-Clone Corp. CLIAs for UGT8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q16880

    ProtoNet protein and cluster: Q16880

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: CGT_HUMAN, Q16880
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGT_HUMAN, Q16880
    Function: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of
    galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and
    peripheral nervous system
    Catalytic activity: UDP-alpha-D-galactose + 2-(2-hydroxyacyl)sphingosine = UDP +
    1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine

         Genatlas biochemistry entry for UGT8:
    UDP glycosyltransferase 8,UDP-galactose ceramide galactosyl transferase,expressed in the terminal oligodendrocyte
    (CNS) and in Schwann cell (PNS)

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.451

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038512-hydroxyacylsphingosine 1-beta-galactosyltransferase activity IEA--
    GO:0008489UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    UGT8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT8:
     Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ugt8a):
     behavior/neurological  growth/size/body  homeostasis/metabolism  immune system  mortality/aging 
     nervous system 

    UGT8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for UGT8: Ugt8atm1Wst Ugt8atm1Pop

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGT8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGT8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGT8

    miRNA
    Products:
        
    miRTarBase miRNAs that target UGT8:
    hsa-mir-148b-3p (MIRT019304), hsa-mir-16-5p (MIRT031420), hsa-mir-155-5p (MIRT020506), hsa-mir-1 (MIRT023508), hsa-let-7b-5p (MIRT001581), hsa-mir-192-5p (MIRT026181), hsa-mir-1260b (MIRT052725), hsa-mir-215-5p (MIRT024598)

    Block miRNA regulation of human, mouse, rat UGT8 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate UGT8:
    hsa-miR-16-1* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidUGT8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UGT8
    Predesigned siRNA for gene silencing in human, mouse, rat UGT8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UGT8

    Clone
    Products:
         
    OriGene clones in human, mouse for UGT8 (see all 11)
    OriGene ORF clones in mouse, rat for UGT8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UGT8 (NM_001128174)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UGT8
    Browse ESI BIO Cell Lines and PureStem Progenitors for UGT8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CGT_HUMAN, Q16880: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    plasma membrane2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    UGT8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UGT8 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    2Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for UGT8):
        Sphingolipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: CGT_HUMAN, Q16880
    Pathway: Sphingolipid metabolism; galactosylceramide biosynthesis


    UGT8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UGT8: 

              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UGT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT8 (ENSP000003116484) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACER1ENSP000003014524STRING: ENSP00000301452
    ARSAENSP000002161244STRING: ENSP00000216124
    ASAH1ENSP000003711524STRING: ENSP00000371152
    CERKENSP000002162644STRING: ENSP00000216264
    DEGS1ENSP000003164764STRING: ENSP00000316476
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002175protein localization to paranode region of axon IEA--
    GO:0005975carbohydrate metabolic process ----
    GO:0006682galactosylceramide biosynthetic process IEA--
    GO:0007010cytoskeleton organization IEA--
    GO:0007417central nervous system development TAS8661025

    UGT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT8 (CGT)

    Selected HMDB Compounds for UGT8 (see all 44)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cer(d18:0/12:0) ----
    Cer(d18:0/14:0) ----
    Cer(d18:0/16:0) ----
    Cer(d18:0/18:0) ----
    Cer(d18:0/18:1(11Z)) ----
    Cer(d18:0/18:1(9Z)) ----
    Cer(d18:0/20:0) ----
    Cer(d18:0/22:0) ----
    Cer(d18:0/22:1(13Z)) ----
    Cer(d18:0/23:0) ----

    7 Novoseek inferred chemical compound relationships for UGT8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebroside 85.9 4 9007051 (2), 17715338 (1), 8661025 (1), 16125333 (1)
    glycosphingolipid 80.1 3 8661123 (1), 11342220 (1), 15901676 (1)
    ceramide 79.4 14 9007051 (2), 15128268 (1), 12540565 (1), 16100442 (1) (see all 10)
    lactosylceramide 77.6 2 12232838 (1), 16100442 (1)
    sulfatide 65.9 1 17715338 (1), 9482258 (1)
    glycolipid 58.3 1 15229398 (1)
    lipid 0 1 17715338 (1), 19187445 (1)



    UGT8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UGT8 gene (2 alternative transcripts): 
    NM_001128174.1  NM_003360.3  

    Unigene Cluster for UGT8:

    UDP glycosyltransferase 8
    Hs.144197  [show with all ESTs]
    Unigene Representative Sequence: NM_001128174
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310836(uc003ibs.2 uc011cge.1) ENST00000507710 ENST00000394511(uc003ibt.2)


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UGT8 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate UGT8:
    hsa-miR-16-1* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidUGT8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UGT8
    Predesigned siRNA for gene silencing in human, mouse, rat UGT8
    Clone
    Products:
         
    OriGene clones in human, mouse for UGT8 (see all 11)
    OriGene ORF clones in mouse, rat for UGT8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UGT8 (NM_001128174)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT8
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UGT8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGT8
      QuantiTect SYBR Green Assays in human, mouse, rat UGT8
      QuantiFast Probe-based Assays in human, mouse, rat UGT8

    Additional mRNA sequence: 

    AK127970.1 AK225763.1 AK294438.1 AL137342.1 BC075069.2 U30930.1 U62899.1 

    6 DOTS entries:

    DT.411084  DT.95233202  DT.121268015  DT.121268014  DT.95154636  DT.97809149 

    Selected AceView cDNA sequences (see all 67):

    AA811893 AW188429 AI499154 H88292 CB123316 BU171669 BM766906 BU618972 
    BP362566 CB129676 AI949364 BM837159 AA553772 N46775 AL137342 AU129743 
    BI603568 BC075069 AL118812 NM_003360 U62899 BU854341 BU954038 AI357484 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for UGT8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -                                       
    SP2:                                                      


    ECgene alternative splicing isoforms for UGT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UGT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTAAAATA
    UGT8 Expression
    About this image


    UGT8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Gonad
             XX Germ Cells Ovigerous Cord
    UGT8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.144197
        Pathway & Disease-focused RT2 Profiler PCR Array including UGT8: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UGT8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGT8
    QuantiTect SYBR Green Assays in human, mouse, rat UGT8
    QuantiFast Probe-based Assays in human, mouse, rat UGT8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for UGT8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt8a1 , 5 UDP galactosyltransferase 8A1, 5 90.08(n)1
    93.35(a)1
      3 (54.68 cM)5
    222391  NM_011674.41  NP_035804.21 
     1258653595 
    chicken
    (Gallus gallus)
    Aves UGT81 UDP glycosyltransferase 8 81.08(n)
    84.66(a)
      374033  NM_204204.1  NP_989535.1 
    lizard
    (Anolis carolinensis)
    Reptilia UGT86
    UDP glycosyltransferase 8
    82(a)
    1 ↔ 1
    5(142020167-142070906)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.97272 Transcribed sequence with weak similarity to protein more 77.03(n)    137716941 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1366521 zgc:136652 68.29(n)
    71.86(a)
      553508  NM_001044325.1  NP_001037790.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ugt86Di3
    CG304381
    glucuronosyltransferase3
    CG304381
    34(a)
    (best of 14)3
    46.45(n)1
    35.4(a)1
      86D73
    2466141  NM_001273781.11  NP_001260710.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C17G1.33
    ugt-581
    UDP-glucosyltransferase3
    ugt-581
    29(a)
    (best of 14)3
    44.49(n)1
    32.05(a)1
      X(9958179-9960324)3
    1745071  NM_063658.61  NP_496059.21 


    ENSEMBL Gene Tree for UGT8 (if available)
    TreeFam Gene Tree for UGT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UGT8 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  
    UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    Selected SIMAP similar genes for UGT8 using alignment to 2 protein entries:     CGT_HUMAN (see all proteins) (see all similar genes):
    UGT2A3    UGT2B10    UGT1A8S    UGT2B7    UGT2B11    UGT2B17
    UGT2B4    UGT2B15    UGT2B28    UGT3A1    UGT1A8    UGT1A10
    UGT1A5    UGT3A2    BILIQTL1    UGT1A3    UGT1A4    UGT1A1

    UGT8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UGT8 (see all 1432)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875232781,2
    --115517679(+) AATACC/TATACT 1 -- us2k10--------
    rs726779321,2
    C,F--115517933(+) GGGGCG/AGTGAA 1 -- us2k12Minor allele frequency- A:0.14NA EA 240
    rs1932858801,2
    --115518101(+) ATAGAC/TAGATT 1 -- us2k10--------
    rs1447882001,2
    C--115518128(+) TGGACA/GTATCT 1 -- us2k10--------
    rs1485498501,2
    --115518266(+) AAAGTG/TGTTTT 1 -- us2k10--------
    rs113524671,2
    C--115518463(+) AGTATG/-GTAAT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1149872211,2
    --115518467(+) TGGTAA/GTCAGG 1 -- us2k10--------
    rs1421226951,2
    --115518513(+) CAGGGA/TATATG 1 -- us2k10--------
    rs126493881,2
    C,F,H--115518575(+) GCATTT/AGAAGA 1 -- us2k18Minor allele frequency- A:0.22NS EA NA WA 772
    rs1854276541,2
    --115518693(+) TTCCGC/TTTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UGT8 (115519611 - 115599380 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for UGT8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273665CNV Insertion20981092
    esv271385CNV Insertion20981092
    nsv509924CNV Loss20534489
    nsv4479CNV Loss18451855
    nsv4478CNV Loss18451855
    nsv879735CNV Gain21882294
    nsv524515CNV Gain19592680
    esv2752021CNV Gain17911159
    nsv830039CNV Gain17160897
    dgv1661e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): UGT8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT8
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601291    OMIM disorders: --

    15 diseases for UGT8:    
    About MalaCards
    acid sphingomyelinase deficiency    metachromatic leukodystrophy    galactosemia    niemann-pick disease
    pick's disease    oligodendroglioma    leukodystrophy    alcohol dependence
    astrocytoma    schizophrenia    hiv-1    thyroiditis
    endotheliitis    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for UGT8:
    Oligodendroglioma

    UGT8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for UGT8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligodendroglioma 64 2 11342220 (1), 15229398 (1)
    tumors 0 4 19125296 (2), 11939588 (1), 18058224 (1)

    Genetic Association Database (GAD): UGT8
    Human Genome Epidemiology (HuGE) Navigator: UGT8 (4 documents)

    Export disorders for UGT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UGT8 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with UGT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26. (PubMed id 8661025)1, 2, 3, 9 Bosio A.... Stoffel W. (Genomics 1996)
    2. Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA. (PubMed id 9125199)1, 2, 9 Kapitonov D.E. and Yu R.K. (Biochem. Biophys. Res. Commun. 1997)
    3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer. (PubMed id 19125296)1, 9 RuckhAoberle E....Kaufmann M. (J. Cancer Res. Clin. Oncol. 2009)
    8. The molecular relationship between deficient UDP-galactose uridyl transferase (GALT) and ceramide galactosyltransferase (CGT) enzyme function: a possible cause for poor long-term prognosis in classic galactosemia. (PubMed id 16125333)1, 9 Lebea P.J. and Pretorius P.J. (Med. Hypotheses 2005)
    9. Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE. (PubMed id 15229398)1, 9 Tencomnao T....Yu R.K. (Glycoconj. J. 2004)
    10. Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population. (PubMed id 23118445)1 Park H....Seo J.S. (J. Med. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7368 HGNC: 12555 AceView: UGT8 Ensembl:ENSG00000174607 euGenes: HUgn7368
    ECgene: UGT8 Kegg: 7368 H-InvDB: UGT8

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UGT8 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_449

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UGT8 gene:
    Search GeneIP for patents involving UGT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UGT8   OriGene RNAi products in human, mouse, rat for UGT8  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UGT8  
     OriGene qSTAR qPCR primer pairs in human, mouse for UGT8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UGT8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UGT8   OriGene Custom Protein Services for UGT8  

     
     
     Block miRNA regulation of human, mouse, rat UGT8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UGT8
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT8 Predesigned siRNA for gene silencing in human, mouse, rat UGT8
     QuantiFast Probe-based Assays in human, mouse, rat UGT8 QuantiTect SYBR Green Assays in human, mouse, rat UGT8
     PCR Arrays including human, mouse, rat UGT8 Search Chromatin IP Primers for UGT8
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGT8  GeneGlobe Interaction Network for UGT8
     Regulatory tfbs in UGT8 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UGT8 GenScript cDNA clones with any tag delivered in your preferred vector for UGT8
     GenScript Custom Assay Services for UGT8 GenScript Custom overexpressing Cell Line Services for UGT8
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UGT8 (CGT)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UGT8 antibodies
     UGT8 proteins
     Antibodies for UGT8
     See all of Abcam's Antibodies, Kits and Proteins for UGT8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UGT8
     Antibodies for UGT8
     ELISAs for UGT8
     CLIAs for UGT8



     Browse ESI BIO Cell Lines and PureStem Progenitors for UGT8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT8
     SwitchGear 3'UTR luciferase reporter plasmids for UGT8
     SwitchGear Promoter luciferase reporter plasmids for UGT8
     Search ThermoFisher Antibodies for UGT8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT8
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT8
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGT8
     LSBio Antibodies in human, mouse, rat for UGT8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UGT8 gene at Home site.
    Version: 3.12.158 12 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4