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UGT3A2 Gene

protein-coding   GIFtS: 52
GCID: GC05M035985

UDP Glycosyltransferase 3 Family, Polypeptide A2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
UDP Glycosyltransferase 3 Family, Polypeptide A21 2
UDPGT 3A22 3
UDP-Glucuronosyltransferase 3A22
EC 2.4.1.173

External Ids:    HGNC: 272661   Entrez Gene: 1671272   Ensembl: ENSG000001686717   UniProtKB: Q3SY773   
ORGUL members:         

Export aliases for UGT3A2 gene to outside databases

Previous GC identifer: GC05M036071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UGT3A2 Gene:
UGT3A2 (UDP glycosyltransferase 3 family, polypeptide A2) is a protein-coding gene. Diseases associated with UGT3A2 include fascioliasis, and gilbert syndrome. GO annotations related to this gene include UDP-glycosyltransferase activity and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD3A2_HUMAN, Q3SY77
Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic
substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of
major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous
compounds (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UGT3A2 gene promoter:
         ARP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGT3A2 promoter sequence
   Search Chromatin IP Primers for UGT3A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT3A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13.2

UGT3A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT3A2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M035985:  view genomic region     (about GC identifiers)

Start:
36,035,119 bp from pter      End:
36,071,460 bp from pter
Size:
36,342 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UD3A2_HUMAN, Q3SY77 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 3A2 precursor  
Size: 523 amino acids; 59547 Da
Secondary accessions: B4DUQ7 E9PFK7 Q6UXC4 Q8NBP2
Alternative splicing: 2 isoforms:  Q3SY77-1   Q3SY77-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UGT3A2: NX_Q3SY77

Explore proteomics data for UGT3A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn52
  • Modification sites at PhosphoSitePlus

  • See UGT3A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161788.1  NP_777574.2  

    ENSEMBL proteins: 
     ENSP00000282507   ENSP00000427404   ENSP00000426017   ENSP00000420865   ENSP00000445367  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q3SY77

    ProtoNet protein and cluster: Q3SY77

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD3A2_HUMAN, Q3SY77
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT3A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD3A2_HUMAN, Q3SY77
    Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic
    substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of
    major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous
    compounds (By similarity)
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008194UDP-glycosyltransferase activity IDA--
    GO:0015020glucuronosyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    UGT3A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT3A2:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT3A2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UD3A2_HUMAN, Q3SY77: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    extracellular2
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    UGT3A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UGT3A2
    Interactions:

        Search GeneGlobe Interaction Network for UGT3A2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for UGT3A2 (ENSP000002825074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPL16ENSP000003001514STRING: ENSP00000300151
    MRPL3ENSP000002649954STRING: ENSP00000264995
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0008152metabolic process ----
    GO:0030259lipid glycosylation ----
    GO:0071412cellular response to genistein IDA--

    UGT3A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT3A2 (UD3A2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UGT3A2 gene (2 alternative transcripts): 
    NM_001168316.1  NM_174914.3  

    Unigene Cluster for UGT3A2:

    UDP glycosyltransferase 3 family, polypeptide A2
    Hs.348941  [show with all ESTs]
    Unigene Representative Sequence: NM_174914
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282507(uc003jjz.2 uc011cos.2 uc011cot.2) ENST00000513300
    ENST00000504685 ENST00000504954 ENST00000515131 ENST00000545528
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat UGT3A2

    Additional mRNA sequence: 

    AK075383.1 AK300751.1 AK303154.1 AY358416.1 BC103924.1 BC103925.1 NR_031764.1 

    3 DOTS entries:

    DT.204327  DT.120841517  DT.75100675 

    17 AceView cDNA sequences:

    AK075383 NM_174914 BQ216829 F06529 CD050395 Z39483 AI917116 AA633698 
    CB158774 AI580389 BP431975 AY358416 BP431877 BF510946 R19994 AA715548 
    BI827790 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UGT3A2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                                                            
    SP2:                                                            
    SP3:                          -     -                           


    ECgene alternative splicing isoforms for UGT3A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UGT3A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACTGTAG
    UGT3A2 Expression
    About this image


    UGT3A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
    UGT3A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT3A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348941
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UGT3A2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt3a25 UDP glycosyltransferases 3 family, polypeptide A2   --   15 (4.01 cM) 9335550 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    GL343241.1(1595150-1604797)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ugt3a21 UDP glycosyltransferase 3 family, polypeptide A2 57.54(n)
    44.44(a)
      448540  NM_001005027.2  NP_001005027.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ugt5e16
    UDP glucuronosyltransferase 5 family, polypeptide ...
    26(a)
    many ↔ many
    8(14573482-14577195) ENSDARG00000058048
    fruit fly
    (Drosophila melanogaster)
    Insecta Ugt35b6
    Ugt37c16
    (see all 33)
    UDP-glycosyltransferase 37c1
    (see all 33)
    28(a)
    27(a)
    (see all 33)
    many ↔ many
    many ↔ many
    (see all 33)
    3R(6994219-6995955)
    2R(12730801-12732543)
    worm
    (Caenorhabditis elegans)
    Secernentea ugt-586
    Protein UGT-58 (ugt-58) mRNA, complete cds
    22(a)
    1 → many
    II(9584379-9586784) WBGene00009450


    ENSEMBL Gene Tree for UGT3A2 (if available)
    TreeFam Gene Tree for UGT3A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGT3A2 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  
    UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    Selected SIMAP similar genes for UGT3A2 using alignment to 4 protein entries:     UD3A2_HUMAN (see all proteins) (see all similar genes):
    UGT3A1    UGT1A3S    UGT1A9S    UGT2B7    UGT2A3    UGT2B10
    UGT8    BILIQTL1    UGT2B15    UGT1A6    UGT2B17    UGT2B4
    UGT1A5    UGT1A1    UGT1A3    UGT1A4    UGT1A4S    UGT1A8

    UGT3A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UGT3A2 (see all 762)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360364
    A colorectal cancer sample4--see VAR_0360362 R H mis40--------
    rs788293821,2
    C,F--36034629(+) TGGTCT/CCTCAA 3 -- ds50011Minor allele frequency- C:0.09EA 120
    rs766893411,2
    C,F--36034639(+) AGGAAA/CAACAT 3 -- ds50011Minor allele frequency- C:0.09EA 120
    rs1167397081,2
    F--36034666(+) AAACAC/TAGCTA 3 -- ds50011Minor allele frequency- T:0.03WA 118
    rs799755531,2
    C,F--36034714(+) GCTCTA/GTGATT 3 -- ds50011Minor allele frequency- G:0.09EA 120
    rs1424405031,2
    --36034745(+) CCTACC/TTCAGC 3 -- ds50010--------
    rs763133091,2
    C,F--36034761(+) CAACAC/GACTTA 3 -- ds50011Minor allele frequency- G:0.09EA 120
    rs25615711,2
    H--36034785(+) GCCAAT/CTCAGT 3 -- ds50014Minor allele frequency- C:0.00NS EA 416
    rs1513196111,2
    C--36034850(+) CAGCAG/TGCCCA 3 -- ds50010--------
    rs1397830641,2
    C--36034854(+) ATGCCC/TATGAT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for UGT3A2 (36035119 - 36071460 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UGT3A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv32711CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT3A2
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT3A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for UGT3A2:    
    About MalaCards
    fascioliasis    gilbert syndrome    kernicterus    breast and colorectal cancer
    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for UGT3A2:
    Gilbert syndrome

    UGT3A2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UGT3A2
    Human Genome Epidemiology (HuGE) Navigator: UGT3A2 (1 document)

    Export disorders for UGT3A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGT3A2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with UGT3A2)
        Utopia: connect your pdf to the dynamic
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    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes. (PubMed id 22621930)1 Meech R....Mackenzie P.I. (J. Biol. Chem. 2012)
    5. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 167127 HGNC: 27266 AceView: LOC167127 Ensembl:ENSG00000168671 euGenes: HUgn167127
    ECgene: UGT3A2 H-InvDB: UGT3A2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UGT3A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UGT3A2 gene:
    Search GeneIP for patents involving UGT3A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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