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Aliases for UGT3A2 Gene

Aliases for UGT3A2 Gene

  • UDP Glycosyltransferase Family 3 Member A2 2 3 5
  • UDP Glycosyltransferase 3 Family, Polypeptide A2 2
  • EC 2.4.1.17 4
  • UDPGT 3A2 4

External Ids for UGT3A2 Gene

Previous GeneCards Identifiers for UGT3A2 Gene

  • GC05M036071
  • GC05M035985

Summaries for UGT3A2 Gene

GeneCards Summary for UGT3A2 Gene

UGT3A2 (UDP Glycosyltransferase Family 3 Member A2) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT3A1.

UniProtKB/Swiss-Prot for UGT3A2 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT3A2 Gene

Genomics for UGT3A2 Gene

Regulatory Elements for UGT3A2 Gene

Enhancers for UGT3A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around UGT3A2 on UCSC Golden Path with GeneCards custom track

Promoters for UGT3A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the UGT3A2 gene promoter:

Genomic Location for UGT3A2 Gene

Chromosome:
5
Start:
36,035,017 bp from pter
End:
36,071,358 bp from pter
Size:
36,342 bases
Orientation:
Minus strand

Genomic View for UGT3A2 Gene

Genes around UGT3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT3A2 Gene

Proteins for UGT3A2 Gene

  • Protein details for UGT3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SY77-UD3A2_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 3A2
    Protein Accession:
    Q3SY77
    Secondary Accessions:
    • B4DUQ7
    • E9PFK7
    • Q6UXC4
    • Q8NBP2

    Protein attributes for UGT3A2 Gene

    Size:
    523 amino acids
    Molecular mass:
    59547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT3A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT3A2 Gene

Post-translational modifications for UGT3A2 Gene

  • Glycosylation at Asn 52
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT3A2 Gene

No data available for DME Specific Peptides for UGT3A2 Gene

Domains & Families for UGT3A2 Gene

Gene Families for UGT3A2 Gene

Protein Domains for UGT3A2 Gene

Suggested Antigen Peptide Sequences for UGT3A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SY77

UniProtKB/Swiss-Prot:

UD3A2_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT3A2: view

Function for UGT3A2 Gene

Molecular function for UGT3A2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Enzyme Numbers (IUBMB) for UGT3A2 Gene

Gene Ontology (GO) - Molecular Function for UGT3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008194 UDP-glycosyltransferase activity IDA 22621930
GO:0015020 glucuronosyltransferase activity IEA --
genes like me logo Genes that share ontologies with UGT3A2: view
genes like me logo Genes that share phenotypes with UGT3A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT3A2 Gene

Localization for UGT3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT3A2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT3A2 Gene COMPARTMENTS Subcellular localization image for UGT3A2 gene
Compartment Confidence
golgi apparatus 3
extracellular 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT3A2: view

Pathways & Interactions for UGT3A2 Gene

SuperPathways for UGT3A2 Gene

No Data Available

Interacting Proteins for UGT3A2 Gene

Gene Ontology (GO) - Biological Process for UGT3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009813 flavonoid biosynthetic process IBA --
GO:0052696 flavonoid glucuronidation IBA --
GO:0071412 cellular response to genistein IDA 22621930
genes like me logo Genes that share ontologies with UGT3A2: view

No data available for Pathways by source and SIGNOR curated interactions for UGT3A2 Gene

Drugs & Compounds for UGT3A2 Gene

(2) Drugs for UGT3A2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UDP-alpha-D-glucuronic acid Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with UGT3A2: view

Transcripts for UGT3A2 Gene

Unigene Clusters for UGT3A2 Gene

UDP glycosyltransferase 3 family, polypeptide A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT3A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1:
SP2:
SP3: - -

Relevant External Links for UGT3A2 Gene

GeneLoc Exon Structure for
UGT3A2
ECgene alternative splicing isoforms for
UGT3A2

Expression for UGT3A2 Gene

mRNA expression in normal human tissues for UGT3A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT3A2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.4), Skin - Sun Exposed (Lower leg) (x16.1), and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for UGT3A2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UGT3A2 Gene



Protein tissue co-expression partners for UGT3A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT3A2 Gene:

UGT3A2

SOURCE GeneReport for Unigene cluster for UGT3A2 Gene:

Hs.348941
genes like me logo Genes that share expression patterns with UGT3A2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UGT3A2 Gene

Orthologs for UGT3A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UGT3A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC537188 34
  • 79.8 (n)
  • 73.61 (a)
UGT3A1 35
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC489231 34
  • 82.68 (n)
  • 75.39 (a)
-- 35
  • 75 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia UGT3A2 34
  • 99.81 (n)
  • 99.81 (a)
mouse
(Mus musculus)
Mammalia Ugt3a1 35
  • 66 (a)
ManyToMany
Ugt3a2 35
  • 66 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ugt3a2 34
  • 57.54 (n)
  • 44.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ugt5e1 35
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10168 35
  • 22 (a)
ManyToMany
CG10170 35
  • 20 (a)
ManyToMany
CG10178 35
  • 26 (a)
ManyToMany
CG11289 35
  • 23 (a)
ManyToMany
CG15661 35
  • 26 (a)
ManyToMany
CG16732 35
  • 22 (a)
ManyToMany
CG17322 35
  • 23 (a)
ManyToMany
CG17323 35
  • 24 (a)
ManyToMany
CG17324 35
  • 26 (a)
ManyToMany
CG30438 35
  • 24 (a)
ManyToMany
CG31002 35
  • 23 (a)
ManyToMany
CG3797 35
  • 18 (a)
ManyToMany
CG4302 35
  • 25 (a)
ManyToMany
CG5724 35
  • 24 (a)
ManyToMany
CG5999 35
  • 23 (a)
ManyToMany
CG6475 35
  • 24 (a)
ManyToMany
Dot 35
  • 19 (a)
ManyToMany
Ugt35a 35
  • 25 (a)
ManyToMany
Ugt35b 35
  • 28 (a)
ManyToMany
Ugt36Ba 35
  • 25 (a)
ManyToMany
Ugt36Bb 35
  • 25 (a)
ManyToMany
Ugt36Bc 35
  • 23 (a)
ManyToMany
Ugt37a1 35
  • 25 (a)
ManyToMany
Ugt37b1 35
  • 24 (a)
ManyToMany
Ugt37c1 35
  • 27 (a)
ManyToMany
Ugt86Da 35
  • 24 (a)
ManyToMany
Ugt86Dc 35
  • 26 (a)
ManyToMany
Ugt86Dd 35
  • 26 (a)
ManyToMany
Ugt86De 35
  • 24 (a)
ManyToMany
Ugt86Dg 35
  • 26 (a)
ManyToMany
Ugt86Dh 35
  • 21 (a)
ManyToMany
Ugt86Di 35
  • 25 (a)
ManyToMany
Ugt86Dj 35
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ugt-58 35
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG26 37
Species where no ortholog for UGT3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UGT3A2 Gene

ENSEMBL:
Gene Tree for UGT3A2 (if available)
TreeFam:
Gene Tree for UGT3A2 (if available)

Paralogs for UGT3A2 Gene

genes like me logo Genes that share paralogs with UGT3A2: view

Variants for UGT3A2 Gene

Sequence variations from dbSNP and Humsavar for UGT3A2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs138640717 A colorectal cancer sample 36,035,726(+) CCCCA(C/G/T)GCAGC nc-transcript-variant, reference, missense
rs2197514 - 36,051,961(-) AATCA(A/T)ATCAA nc-transcript-variant, reference, missense
rs267769 -- 36,064,540(+) GCCCA(A/T)ATTTT intron-variant
rs267770 -- 36,064,571(+) GAGAG(A/G)TTGCC intron-variant
rs267771 -- 36,064,711(+) CGGCA(C/T)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT3A2 Gene

Variant ID Type Subtype PubMed ID
esv32711 CNV gain 17666407
esv3604707 CNV gain 21293372
esv3604711 CNV loss 21293372

Variation tolerance for UGT3A2 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT3A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT3A2 Gene

Disorders for UGT3A2 Gene

Relevant External Links for UGT3A2

Genetic Association Database (GAD)
UGT3A2
Human Genome Epidemiology (HuGE) Navigator
UGT3A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT3A2

No disorders were found for UGT3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT3A2 Gene

Publications for UGT3A2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 65
  2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 65
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for UGT3A2 Gene

Sources for UGT3A2 Gene

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