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Aliases for UGT3A1 Gene

Aliases for UGT3A1 Gene

  • UDP Glycosyltransferase Family 3 Member A1 2 3
  • UDP Glycosyltransferase 3 Family, Polypeptide A1 2 5
  • EC 2.4.1.17 4 63
  • UDPGT 3A1 4
  • EC 2.4.1 63

External Ids for UGT3A1 Gene

Previous GeneCards Identifiers for UGT3A1 Gene

  • GC05M035989
  • GC05M035903

Summaries for UGT3A1 Gene

GeneCards Summary for UGT3A1 Gene

UGT3A1 (UDP Glycosyltransferase Family 3 Member A1) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT3A1 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT3A1 Gene

Genomics for UGT3A1 Gene

Regulatory Elements for UGT3A1 Gene

Enhancers for UGT3A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UGT3A1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UGT3A1 gene promoter:

Genomic Location for UGT3A1 Gene

Chromosome:
5
Start:
35,951,010 bp from pter
End:
36,001,045 bp from pter
Size:
50,036 bases
Orientation:
Minus strand

Genomic View for UGT3A1 Gene

Genes around UGT3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT3A1 Gene

Proteins for UGT3A1 Gene

  • Protein details for UGT3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUS8-UD3A1_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 3A1
    Protein Accession:
    Q6NUS8
    Secondary Accessions:
    • G5E961
    • Q8IYS9
    • Q8NAW4
    • Q96DM6

    Protein attributes for UGT3A1 Gene

    Size:
    523 amino acids
    Molecular mass:
    59151 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT3A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT3A1 Gene

Proteomics data for UGT3A1 Gene at MOPED

Selected DME Specific Peptides for UGT3A1 Gene

Post-translational modifications for UGT3A1 Gene

  • Glycosylation at Asn 52
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT3A1 Gene

Domains & Families for UGT3A1 Gene

Gene Families for UGT3A1 Gene

Protein Domains for UGT3A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NUS8

UniProtKB/Swiss-Prot:

UD3A1_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT3A1: view

Function for UGT3A1 Gene

Molecular function for UGT3A1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Enzyme Numbers (IUBMB) for UGT3A1 Gene

Gene Ontology (GO) - Molecular Function for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008194 UDP-glycosyltransferase activity IDA 22621930
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT3A1: view

Phenotypes for UGT3A1 Gene

genes like me logo Genes that share phenotypes with UGT3A1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT3A1 Gene

Localization for UGT3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT3A1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT3A1 Gene COMPARTMENTS Subcellular localization image for UGT3A1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT3A1: view

Pathways & Interactions for UGT3A1 Gene

SuperPathways for UGT3A1 Gene

No Data Available

Interacting Proteins for UGT3A1 Gene

Gene Ontology (GO) - Biological Process for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052696 flavonoid glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT3A1: view

No data available for Pathways by source and SIGNOR curated interactions for UGT3A1 Gene

Drugs & Compounds for UGT3A1 Gene

(3) Drugs for UGT3A1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Kaempferol Experimental Pharma Target Apoptosis inducer;antioxidant;flavonoid, Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter 0
Quercetin Experimental Nutra Target Antitumor agent, Non-selective PI 3-kinase inhibitor 36
Uridine-5'-Diphosphate Experimental Pharma 0

(1) Additional Compounds for UGT3A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate glucuronic acid
  • a-D-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • a-D-Glucopyranuronic acid ester with uridine 5'-pyrophosphate
  • alpha-D-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
  • alpha-delta-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • alpha-delta-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
2616-64-0
genes like me logo Genes that share compounds with UGT3A1: view

Transcripts for UGT3A1 Gene

Unigene Clusters for UGT3A1 Gene

UDP glycosyltransferase 3 family, polypeptide A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT3A1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2: - - - -
SP3:

Relevant External Links for UGT3A1 Gene

GeneLoc Exon Structure for
UGT3A1
ECgene alternative splicing isoforms for
UGT3A1

Expression for UGT3A1 Gene

mRNA expression in normal human tissues for UGT3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT3A1 Gene

This gene is overexpressed in Liver (x20.4), Kidney - Cortex (x19.3), and Testis (x8.6).

Protein differential expression in normal tissues from HIPED for UGT3A1 Gene

This gene is overexpressed in Kidney (29.2), Fetal gut (27.7), and Testis (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UGT3A1 Gene



SOURCE GeneReport for Unigene cluster for UGT3A1 Gene Hs.254699

genes like me logo Genes that share expression patterns with UGT3A1: view

Protein tissue co-expression partners for UGT3A1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UGT3A1 Gene

Orthologs for UGT3A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT3A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UGT3A1 35
  • 79.29 (n)
  • 71.7 (a)
UGT3A1 36
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ugt3a2 35
  • 74.6 (n)
  • 64.88 (a)
Ugt3a2 16
Ugt3a1 36
  • 64 (a)
ManyToMany
Ugt3a2 36
  • 64 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia UGT3A1 35
  • 98.09 (n)
  • 96.94 (a)
UGT3A1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugt3a2 35
  • 74.72 (n)
  • 67.46 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ugt5b4 36
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10168 36
  • 21 (a)
ManyToMany
CG10170 36
  • 20 (a)
ManyToMany
CG10178 36
  • 26 (a)
ManyToMany
CG11289 36
  • 24 (a)
ManyToMany
CG15661 36
  • 26 (a)
ManyToMany
CG16732 36
  • 22 (a)
ManyToMany
CG17322 36
  • 23 (a)
ManyToMany
CG17323 36
  • 24 (a)
ManyToMany
CG17324 36
  • 24 (a)
ManyToMany
CG30438 36
  • 23 (a)
ManyToMany
CG31002 36
  • 22 (a)
ManyToMany
CG3797 36
  • 19 (a)
ManyToMany
CG4302 36
  • 25 (a)
ManyToMany
CG5724 36
  • 24 (a)
ManyToMany
CG5999 36
  • 22 (a)
ManyToMany
CG6475 36
  • 24 (a)
ManyToMany
Dot 36
  • 19 (a)
ManyToMany
Ugt35a 36
  • 23 (a)
ManyToMany
Ugt35b 36
  • 26 (a)
ManyToMany
Ugt36Ba 36
  • 26 (a)
ManyToMany
Ugt36Bb 36
  • 25 (a)
ManyToMany
Ugt36Bc 36
  • 23 (a)
ManyToMany
Ugt37a1 36
  • 23 (a)
ManyToMany
Ugt37b1 36
  • 25 (a)
ManyToMany
Ugt37c1 36
  • 27 (a)
ManyToMany
Ugt86Da 36
  • 23 (a)
ManyToMany
Ugt86Dc 36
  • 24 (a)
ManyToMany
Ugt86Dd 36
  • 24 (a)
ManyToMany
Ugt86De 36
  • 23 (a)
ManyToMany
Ugt86Dg 36
  • 24 (a)
ManyToMany
Ugt86Dh 36
  • 21 (a)
ManyToMany
Ugt86Di 36
  • 23 (a)
ManyToMany
Ugt86Dj 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ugt-58 36
  • 23 (a)
OneToMany
Species with no ortholog for UGT3A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT3A1 Gene

ENSEMBL:
Gene Tree for UGT3A1 (if available)
TreeFam:
Gene Tree for UGT3A1 (if available)

Paralogs for UGT3A1 Gene

Pseudogenes.org Pseudogenes for UGT3A1 Gene

genes like me logo Genes that share paralogs with UGT3A1: view

Variants for UGT3A1 Gene

Sequence variations from dbSNP and Humsavar for UGT3A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3756669 - 35,965,868(-) CTCAA(G/T)GTAGT nc-transcript-variant, reference, missense
rs745300 -- 35,988,848(+) GATTA(C/T)GCCTG intron-variant
rs768621 -- 35,955,924(-) GCTTT(A/G)CCTGG intron-variant
rs768622 -- 35,955,580(-) ATACT(C/G)TGTAT intron-variant
rs768623 -- 35,955,794(-) CATGG(G/T)GTGCC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UGT3A1 Gene

Variant ID Type Subtype PubMed ID
nsv483069 CNV Gain 15286789
nsv471011 CNV Gain 18288195
nsv830261 CNV Gain 17160897

Variation tolerance for UGT3A1 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UGT3A1 Gene

Disorders for UGT3A1 Gene

Relevant External Links for UGT3A1

Genetic Association Database (GAD)
UGT3A1
Human Genome Epidemiology (HuGE) Navigator
UGT3A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT3A1

No disorders were found for UGT3A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT3A1 Gene

Publications for UGT3A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  4. Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes. (PMID: 22621930) Meech R. … Mackenzie P.I. (J. Biol. Chem. 2012) 3
  5. UGT3A: novel UDP-glycosyltransferases of the UGT superfamily. (PMID: 19814657) Meech R. … Mackenzie P.I. (Drug Metab. Rev. 2010) 3

Products for UGT3A1 Gene

Sources for UGT3A1 Gene

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