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Aliases for UGT3A1 Gene

Aliases for UGT3A1 Gene

  • UDP Glycosyltransferase 3 Family, Polypeptide A1 2 3
  • EC 2.4.1.17 4 63
  • UDPGT 3A1 4
  • EC 2.4.1 63

External Ids for UGT3A1 Gene

Previous GeneCards Identifiers for UGT3A1 Gene

  • GC05M035989
  • GC05M035903

Summaries for UGT3A1 Gene

GeneCards Summary for UGT3A1 Gene

UGT3A1 (UDP Glycosyltransferase 3 Family, Polypeptide A1) is a Protein Coding gene. Diseases associated with UGT3A1 include gilbert syndrome. GO annotations related to this gene include glucuronosyltransferase activity and UDP-glycosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT3A1 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT3A1 Gene

Genomics for UGT3A1 Gene

Regulatory Elements for UGT3A1 Gene

Transcription factor binding sites by QIAGEN in the UGT3A1 gene promoter:

Genomic Location for UGT3A1 Gene

Start:
35,951,010 bp from pter
End:
36,001,028 bp from pter
Size:
50,019 bases
Orientation:
Minus strand

Genomic View for UGT3A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT3A1 Gene

Proteins for UGT3A1 Gene

  • Protein details for UGT3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUS8-UD3A1_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 3A1
    Protein Accession:
    Q6NUS8
    Secondary Accessions:
    • G5E961
    • Q8IYS9
    • Q8NAW4
    • Q96DM6

    Protein attributes for UGT3A1 Gene

    Size:
    523 amino acids
    Molecular mass:
    59151 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT3A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT3A1 Gene

Proteomics data for UGT3A1 Gene at MOPED

Selected DME Specific Peptides for UGT3A1 Gene

Post-translational modifications for UGT3A1 Gene

  • Glycosylation at Asn52
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT3A1 Gene

Domains for UGT3A1 Gene

Gene Families for UGT3A1 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT3A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NUS8

UniProtKB/Swiss-Prot:

UD3A1_HUMAN :
  • Q6NUS8
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT3A1: view

Function for UGT3A1 Gene

Molecular function for UGT3A1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
UniProtKB/Swiss-Prot Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Enzyme Numbers (IUBMB) for UGT3A1 Gene

Gene Ontology (GO) - Molecular Function for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008194 UDP-glycosyltransferase activity IDA 22621930
GO:0015020 glucuronosyltransferase activity IDA 22621930
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT3A1: view

Phenotypes for UGT3A1 Gene

GenomeRNAi human phenotypes for UGT3A1:
genes like me logo Genes that share phenotypes with UGT3A1: view

Animal Model Products

CRISPR Products

miRNA for UGT3A1 Gene

miRTarBase miRNAs that target UGT3A1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UGT3A1 Gene

Localization for UGT3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT3A1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT3A1 Gene COMPARTMENTS Subcellular localization image for UGT3A1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0043541 UDP-N-acetylglucosamine transferase complex IDA 22621930
genes like me logo Genes that share ontologies with UGT3A1: view

Pathways for UGT3A1 Gene

SuperPathways for UGT3A1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat

Interacting Proteins for UGT3A1 Gene

Gene Ontology (GO) - Biological Process for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0008152 metabolic process --
GO:0009813 flavonoid biosynthetic process IBA --
GO:0030259 lipid glycosylation --
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with UGT3A1: view

No data available for Pathways by source for UGT3A1 Gene

Compounds for UGT3A1 Gene

(2) Drugbank Compounds for UGT3A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Kaempherol
520-18-3 target
Quercetin
117-39-5 target
genes like me logo Genes that share compounds with UGT3A1: view

Transcripts for UGT3A1 Gene

Unigene Clusters for UGT3A1 Gene

UDP glycosyltransferase 3 family, polypeptide A1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UGT3A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UGT3A1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT3A1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2: - - - -
SP3:

Relevant External Links for UGT3A1 Gene

GeneLoc Exon Structure for
UGT3A1
ECgene alternative splicing isoforms for
UGT3A1

Expression for UGT3A1 Gene

mRNA expression in normal human tissues for UGT3A1 Gene

mRNA differential expression in normal tissues according to GTEx for UGT3A1 Gene

This gene is overexpressed in Liver (20.4), Kidney - Cortex (19.3), and Testis (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UGT3A1 Gene

SOURCE GeneReport for Unigene cluster for UGT3A1 Gene Hs.254699

genes like me logo Genes that share expressions with UGT3A1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UGT3A1 Gene

Orthologs for UGT3A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT3A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT3A1 35
  • 98.09 (n)
  • 96.94 (a)
UGT3A1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGT3A1 35
  • 79.29 (n)
  • 71.7 (a)
UGT3A1 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt3a1 36
  • 64 (a)
ManyToMany
Ugt3a2 35
  • 74.6 (n)
  • 64.88 (a)
Ugt3a2 36
  • 64 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt3a2 35
  • 74.72 (n)
  • 67.46 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ugt5b4 36
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10168 36
  • 21 (a)
ManyToMany
CG10170 36
  • 20 (a)
ManyToMany
CG10178 36
  • 26 (a)
ManyToMany
CG11289 36
  • 24 (a)
ManyToMany
CG15661 36
  • 26 (a)
ManyToMany
CG16732 36
  • 22 (a)
ManyToMany
CG17322 36
  • 23 (a)
ManyToMany
CG17323 36
  • 24 (a)
ManyToMany
CG17324 36
  • 24 (a)
ManyToMany
CG30438 36
  • 23 (a)
ManyToMany
CG31002 36
  • 22 (a)
ManyToMany
CG3797 36
  • 19 (a)
ManyToMany
CG4302 36
  • 25 (a)
ManyToMany
CG5724 36
  • 24 (a)
ManyToMany
CG5999 36
  • 22 (a)
ManyToMany
CG6475 36
  • 24 (a)
ManyToMany
Dot 36
  • 19 (a)
ManyToMany
Ugt35a 36
  • 23 (a)
ManyToMany
Ugt35b 36
  • 26 (a)
ManyToMany
Ugt36Ba 36
  • 26 (a)
ManyToMany
Ugt36Bb 36
  • 25 (a)
ManyToMany
Ugt36Bc 36
  • 23 (a)
ManyToMany
Ugt37a1 36
  • 23 (a)
ManyToMany
Ugt37b1 36
  • 25 (a)
ManyToMany
Ugt37c1 36
  • 27 (a)
ManyToMany
Ugt86Da 36
  • 23 (a)
ManyToMany
Ugt86Dc 36
  • 24 (a)
ManyToMany
Ugt86Dd 36
  • 24 (a)
ManyToMany
Ugt86De 36
  • 23 (a)
ManyToMany
Ugt86Dg 36
  • 24 (a)
ManyToMany
Ugt86Dh 36
  • 21 (a)
ManyToMany
Ugt86Di 36
  • 23 (a)
ManyToMany
Ugt86Dj 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ugt-58 36
  • 23 (a)
OneToMany
Species with no ortholog for UGT3A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT3A1 Gene

ENSEMBL:
Gene Tree for UGT3A1 (if available)
TreeFam:
Gene Tree for UGT3A1 (if available)

Paralogs for UGT3A1 Gene

Pseudogenes.org Pseudogenes for UGT3A1 Gene

genes like me logo Genes that share paralogs with UGT3A1: view

Variants for UGT3A1 Gene

Sequence variations from dbSNP and Humsavar for UGT3A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs700162 -- 35,963,405(-) gatac(A/C)tgcag intron-variant
rs700163 -- 35,958,497(-) AAGAA(A/C)AACAA intron-variant
rs700164 -- 35,954,486(-) TCTCC(A/G)CCAAC intron-variant
rs700165 -- 35,954,041(-) TTCAC(A/G)CACCA utr-variant-3-prime
rs700166 -- 35,953,358(-) CATGG(C/T)GTAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UGT3A1 Gene

Variant ID Type Subtype PubMed ID
nsv483069 CNV Gain 15286789
nsv471011 CNV Gain 18288195
nsv830261 CNV Gain 17160897

Relevant External Links for UGT3A1 Gene

HapMap Linkage Disequilibrium report
UGT3A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT3A1 Gene

Disorders for UGT3A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UGT3A1 Gene including...

Search for UGT3A1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UGT3A1 Gene

Relevant External Links for UGT3A1

Genetic Association Database (GAD)
UGT3A1
Human Genome Epidemiology (HuGE) Navigator
UGT3A1
genes like me logo Genes that share disorders with UGT3A1: view

No data available for UniProtKB/Swiss-Prot for UGT3A1 Gene

Publications for UGT3A1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  4. Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes. (PMID: 22621930) Meech R. … Mackenzie P.I. (J. Biol. Chem. 2012) 3
  5. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3

Products for UGT3A1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate UGT3A1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for UGT3A1
    • Block miRNA regulation of UGT3A1 using miScript Target Protectors

    Sources for UGT3A1 Gene

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