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Aliases for UGT3A1 Gene

Aliases for UGT3A1 Gene

  • UDP Glycosyltransferase Family 3 Member A1 2 3 5
  • EC 2.4.1.17 4 61
  • UDP Glycosyltransferase 3 Family, Polypeptide A1 2
  • UDPGT 3A1 4
  • EC 2.4.1 61

External Ids for UGT3A1 Gene

Previous GeneCards Identifiers for UGT3A1 Gene

  • GC05M035989
  • GC05M035903

Summaries for UGT3A1 Gene

GeneCards Summary for UGT3A1 Gene

UGT3A1 (UDP Glycosyltransferase Family 3 Member A1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT3A2.

UniProtKB/Swiss-Prot for UGT3A1 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT3A1 Gene

Genomics for UGT3A1 Gene

Regulatory Elements for UGT3A1 Gene

Enhancers for UGT3A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G036229 0.3 FANTOM5 1.6 -228.8 -228769 0.1 RANBP3L NADK2 UGT3A1 NADK2-AS1
GH05G035990 0.7 ENCODE 0.4 +9.8 9752 2.3 PHF8 TAF1 MAX RBBP5 REST RAD21 YY1 JUND ATF3 POLR2A UGT3A1 PIR32884
GH05G036016 0.5 ENCODE 0.4 -16.5 -16496 1.9 RAD51 HNF4G HNF4A GC05M036000 UGT3A1
GH05G036003 0.5 ENCODE 0.4 -5.8 -5757 5.9 CBX3 CBX5 ZNF140 TCF7 HNF4A LOC105374724 UGT3A2 UGT3A1 GC05M036000
GH05G035995 0.2 ENCODE 0.4 +5.0 5008 1.8 UGT3A1 PIR32884
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UGT3A1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UGT3A1 gene promoter:

Genomic Location for UGT3A1 Gene

Chromosome:
5
Start:
35,951,010 bp from pter
End:
36,001,045 bp from pter
Size:
50,036 bases
Orientation:
Minus strand

Genomic View for UGT3A1 Gene

Genes around UGT3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT3A1 Gene

Proteins for UGT3A1 Gene

  • Protein details for UGT3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUS8-UD3A1_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 3A1
    Protein Accession:
    Q6NUS8
    Secondary Accessions:
    • G5E961
    • Q8IYS9
    • Q8NAW4
    • Q96DM6

    Protein attributes for UGT3A1 Gene

    Size:
    523 amino acids
    Molecular mass:
    59151 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT3A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT3A1 Gene

Selected DME Specific Peptides for UGT3A1 Gene

Q6NUS8:
  • AFAHLPQGV
  • PAQRLVG

Post-translational modifications for UGT3A1 Gene

  • Glycosylation at posLast=5252
  • Modification sites at PhosphoSitePlus

Domains & Families for UGT3A1 Gene

Gene Families for UGT3A1 Gene

Protein Domains for UGT3A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NUS8

UniProtKB/Swiss-Prot:

UD3A1_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT3A1: view

Function for UGT3A1 Gene

Molecular function for UGT3A1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Enzyme Numbers (IUBMB) for UGT3A1 Gene

Gene Ontology (GO) - Molecular Function for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008194 UDP-glycosyltransferase activity IDA 22621930
GO:0015020 glucuronosyltransferase activity IDA 22621930
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT3A1: view

Phenotypes for UGT3A1 Gene

genes like me logo Genes that share phenotypes with UGT3A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT3A1 Gene

Localization for UGT3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT3A1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT3A1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043541 UDP-N-acetylglucosamine transferase complex IDA 22621930
genes like me logo Genes that share ontologies with UGT3A1: view

Pathways & Interactions for UGT3A1 Gene

genes like me logo Genes that share pathways with UGT3A1: view

Pathways by source for UGT3A1 Gene

Gene Ontology (GO) - Biological Process for UGT3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with UGT3A1: view

No data available for SIGNOR curated interactions for UGT3A1 Gene

Drugs & Compounds for UGT3A1 Gene

(4) Drugs for UGT3A1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Kaempherol Experimental Pharma Target 0
Quercetin Experimental Nutra Target Antitumor agent 41
UDP-alpha-D-glucuronic acid Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with UGT3A1: view

Transcripts for UGT3A1 Gene

Unigene Clusters for UGT3A1 Gene

UDP glycosyltransferase 3 family, polypeptide A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT3A1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2: - - - -
SP3:

Relevant External Links for UGT3A1 Gene

GeneLoc Exon Structure for
UGT3A1
ECgene alternative splicing isoforms for
UGT3A1

Expression for UGT3A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGT3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT3A1 Gene

This gene is overexpressed in Liver (x20.4), Kidney - Cortex (x19.3), and Testis (x8.6).

Protein differential expression in normal tissues from HIPED for UGT3A1 Gene

This gene is overexpressed in Kidney (29.2), Fetal gut (27.7), and Testis (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UGT3A1 Gene



Protein tissue co-expression partners for UGT3A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT3A1 Gene:

UGT3A1

SOURCE GeneReport for Unigene cluster for UGT3A1 Gene:

Hs.254699

Evidence on tissue expression from TISSUES for UGT3A1 Gene

  • Kidney(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with UGT3A1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT3A1 Gene

Orthologs for UGT3A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT3A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT3A1 34 35
  • 98.09 (n)
cow
(Bos Taurus)
Mammalia UGT3A1 34 35
  • 79.29 (n)
rat
(Rattus norvegicus)
Mammalia Ugt3a2 34
  • 74.72 (n)
mouse
(Mus musculus)
Mammalia Ugt3a2 34 16 35
  • 74.6 (n)
Ugt3a1 35
  • 64 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 71 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ugt5b4 35
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ugt37c1 35
  • 27 (a)
ManyToMany
CG10178 35
  • 26 (a)
ManyToMany
CG15661 35
  • 26 (a)
ManyToMany
Ugt35b 35
  • 26 (a)
ManyToMany
Ugt36Ba 35
  • 26 (a)
ManyToMany
CG4302 35
  • 25 (a)
ManyToMany
Ugt36Bb 35
  • 25 (a)
ManyToMany
Ugt37b1 35
  • 25 (a)
ManyToMany
CG11289 35
  • 24 (a)
ManyToMany
CG17323 35
  • 24 (a)
ManyToMany
CG17324 35
  • 24 (a)
ManyToMany
CG5724 35
  • 24 (a)
ManyToMany
CG6475 35
  • 24 (a)
ManyToMany
Ugt86Dc 35
  • 24 (a)
ManyToMany
Ugt86Dd 35
  • 24 (a)
ManyToMany
Ugt86Dg 35
  • 24 (a)
ManyToMany
CG17322 35
  • 23 (a)
ManyToMany
CG30438 35
  • 23 (a)
ManyToMany
Ugt35a 35
  • 23 (a)
ManyToMany
Ugt36Bc 35
  • 23 (a)
ManyToMany
Ugt37a1 35
  • 23 (a)
ManyToMany
Ugt86Da 35
  • 23 (a)
ManyToMany
Ugt86De 35
  • 23 (a)
ManyToMany
Ugt86Di 35
  • 23 (a)
ManyToMany
CG16732 35
  • 22 (a)
ManyToMany
CG31002 35
  • 22 (a)
ManyToMany
CG5999 35
  • 22 (a)
ManyToMany
CG10168 35
  • 21 (a)
ManyToMany
Ugt86Dh 35
  • 21 (a)
ManyToMany
CG10170 35
  • 20 (a)
ManyToMany
CG3797 35
  • 19 (a)
ManyToMany
Dot 35
  • 19 (a)
ManyToMany
Ugt86Dj 35
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ugt-58 35
  • 23 (a)
OneToMany
Species where no ortholog for UGT3A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT3A1 Gene

ENSEMBL:
Gene Tree for UGT3A1 (if available)
TreeFam:
Gene Tree for UGT3A1 (if available)

Paralogs for UGT3A1 Gene

Variants for UGT3A1 Gene

Sequence variations from dbSNP and Humsavar for UGT3A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000064866 -- 35,982,298(+) AAGCT(G/T)CAGGC intron-variant
rs1000084317 -- 35,988,566(+) ATGCA(C/T)AATGT intron-variant
rs1000115241 -- 35,978,192(+) TCCAG(G/T)CCTGG intron-variant
rs1000174482 -- 35,976,410(+) AAGGA(A/T)AACTA intron-variant
rs1000274923 -- 35,953,758(+) GTTTC(C/T)TGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UGT3A1 Gene

Variant ID Type Subtype PubMed ID
esv3604707 CNV gain 21293372
nsv471011 CNV gain 18288195
nsv483069 CNV gain 15286789
nsv830261 CNV gain 17160897

Variation tolerance for UGT3A1 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT3A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT3A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT3A1 Gene

Disorders for UGT3A1 Gene

Relevant External Links for UGT3A1

Genetic Association Database (GAD)
UGT3A1
Human Genome Epidemiology (HuGE) Navigator
UGT3A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT3A1

No disorders were found for UGT3A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT3A1 Gene

Publications for UGT3A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64

Products for UGT3A1 Gene

Sources for UGT3A1 Gene

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