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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT3A1 Gene

protein-coding   GIFtS: 46
GCID: GC05M035951

UDP Glycosyltransferase 3 Family, Polypeptide A1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP Glycosyltransferase 3 Family, Polypeptide A11 2
UDPGT 3A12 3
EC 2.4.1.173 8
UDP-Glucuronosyltransferase 3A12
EC 2.4.18

External Ids:    HGNC: 266251   Entrez Gene: 1336882   Ensembl: ENSG000001456267   UniProtKB: Q6NUS83   

Export aliases for UGT3A1 gene to outside databases

Previous GC identifers: GC05M035989 GC05M035903


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UGT3A1 Gene: 
UGT3A1 (UDP glycosyltransferase 3 family, polypeptide A1) is a protein-coding gene. Diseases associated with UGT3A1 include fascioliasis, and kernicterus. GO annotations related to this gene include glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD3A1_HUMAN, Q6NUS8
Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic
substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of
major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous
compounds (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT3A1 gene promoter:
         IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGT3A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGT3A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT3A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13.2

UGT3A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT3A1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M035951:  view genomic region     (about GC identifiers)

Start:
35,951,112 bp from pter      End:
36,001,130 bp from pter
Size:
50,019 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UD3A1_HUMAN, Q6NUS8 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 3A1 precursor  
Size: 523 amino acids; 59151 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: G5E961 Q8IYS9 Q8NAW4 Q96DM6
Alternative splicing: 2 isoforms:  Q6NUS8-1   Q6NUS8-2   (No experimental confirmation available. Ref.2 (AAH35012) sequence is in conflict in position: 251:W->R)

Explore the universe of human proteins at neXtProt for UGT3A1: NX_Q6NUS8

Explore proteomics data for UGT3A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NUS8

  • 2 DME Specific Peptides for UGT3A1 (Q6NUS8)
     PAQRLVG  AFAHLPQGV 

    UGT3A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGT3A1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001165344.1  NP_689617.3  

    ENSEMBL proteins: 
     ENSP00000274278   ENSP00000427630   ENSP00000427079   ENSP00000426100   ENSP00000328033  

    Human Recombinant Protein Products for UGT3A1: 
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    Novus Biologicals UGT3A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UGT3A1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0043541UDP-N-acetylglucosamine transferase complex IDA--

    UGT3A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q6NUS8

    ProtoNet protein and cluster: Q6NUS8

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD3A1_HUMAN, Q6NUS8
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT3A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD3A1_HUMAN, Q6NUS8
    Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic
    substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of
    major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous
    compounds (By similarity)
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Numbers (IUBMB): EC 2.4.1.171 2 EC 2.4.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008194UDP-glycosyltransferase activity IDA--
    GO:0015020glucuronosyltransferase activity IDA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    UGT3A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT3A1:
     Synthetic lethal with Ras 

    Animal Models:
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT3A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT3A1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0008152metabolic process ----
    GO:0030259lipid glycosylation ----

    UGT3A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT3A1 (UD3A1)

    2 DrugBank Compounds for UGT3A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Kaempherol-- 520-18-3target--10592235
    Quercetin-- 117-39-5target--10592235

    Search CenterWatch for drugs/clinical trials and news about UGT3A1 / UD3A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGT3A1 gene (2 alternative transcripts): 
    NM_001171873.1  NM_152404.3  

    Unigene Cluster for UGT3A1:

    UDP glycosyltransferase 3 family, polypeptide A1
    Hs.254699  [show with all ESTs]
    Unigene Representative Sequence: AK125803
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274278(uc003jjv.2) ENST00000515801(uc003jjw.2 uc011coq.2 uc011cor.2)
    ENST00000503189 ENST00000507113 ENST00000513233 ENST00000333811(uc003jjy.2)

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK057066.1 AK091977.1 AK125803.1 AK290809.1 AK296136.1 AK303770.1 AK308046.1 AK315851.1 
    BC035012.1 BC068446.1 

    5 DOTS entries:

    DT.40129342  DT.75101467  DT.95267320  DT.100031080  DT.120853522 

    24/42 AceView cDNA sequences (see all 42):

    AK125803 BX955526 AW235540 AI492912 AI671780 AI613123 AI373521 AI672388 
    BX104774 AK091977 AI425081 AA970255 AI433413 AK057066 BI463768 AW173071 
    AA923244 AI015041 BC035012 AI014966 BC068446 AI767712 BX951484 NM_152404 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UGT3A1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
    SP1:                                            -                           
    SP2:              -                       -     -                 -         
    SP3:                                                                        


    ECgene alternative splicing isoforms for UGT3A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT3A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT3A1 Expression
    About this image


    See UGT3A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT3A1

    SOURCE GeneReport for Unigene cluster: Hs.254699
        SABiosciences Expression via Pathway-Focused PCR Array including UGT3A1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT3A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UGT3A1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    GL343241.1(1595150-1604797)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF218052.12   -- 70.99(n)    CF218052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ugt37c16
    CG156616
    (see all 33)
    --
    26(a)
    25(a)
    (see all 33)
    many ↔ many
    many ↔ many
    (see all 33)
    2R(12730801-12732543)
    2R(17102940-17105284)
    worm
    (Caenorhabditis elegans)
    Secernentea ugt-216
    ugt-456
    (see all 32)
    Protein UGT-45
    (see all 32)
    23(a)
    23(a)
    (see all 32)
    many ↔ many
    many ↔ many
    (see all 32)
    IV(9500311-9502568)
    IV(3748203-3751101)
            Species with no ortholog for UGT3A1

    ENSEMBL Gene Tree for UGT3A1 (if available)
    TreeFam Gene Tree for UGT3A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT3A1 gene
    UGT2A22  UGT1A82  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  UGT3A22  
    UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    18/26 SIMAP similar genes for UGT3A1 using alignment to 5 protein entries:     UD3A1_HUMAN (see all proteins) (see all similar genes):
    UGT3A2    UGT1A9S    UGT1A3S    UGT8    UGT2B10    UGT2B4
    UGT2B15    UGT1A8S    UGT2A3    UGT2B11    UGT2B28    UGT2B7
    UGT1A5    UGT2B17    UGT1A10    UGT2A1    BILIQTL1    UGT1A3

    UGT3A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UGT3A1
    PGOHUM00000235188


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1100 SNPs in UGT3A1 are shown (see all 1100)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833109781,2
    --35952799(+) CCTTCA/GTGGGA 1 -- int10--------
    rs1448048431,2
    C--35952808(+) GAGTAC/TGGCCA 1 -- int10--------
    rs1485286931,2
    --35952868(+) TTATAC/TGCACA 1 -- int10--------
    rs1868912831,2
    --35952869(+) TATACA/GCACAC 1 -- int10--------
    rs1428914951,2
    C--35952903(+) TCTGCA/GTGCTT 1 -- int10--------
    rs1115069391,2
    C,F--35952926(+) TCTTGC/TGTCAT 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs1843103391,2
    C--35952958(+) ACATCC/TAGCAC 1 -- int10--------
    rs1872013201,2
    --35952980(+) GACTCG/TCAAGC 1 -- int10--------
    rs1928182721,2
    --35953009(+) GGCAAA/CGTTTT 1 -- int10--------
    rs64512451,2
    C,F,A,H--35953097(+) TTTCAT/CAATTC 1 -- int111Minor allele frequency- C:0.49NA WA EA 508

    HapMap Linkage Disequilibrium report for UGT3A1 (35951112 - 36001130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UGT3A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471011CNV Gain18288195
    nsv483069CNV Gain15286789
    nsv830261CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for UGT3A1:    About MalaCards
    fascioliasis    kernicterus

    1 disease from the University of Copenhagen DISEASES database for UGT3A1:
    Gilbert syndrome

    UGT3A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UGT3A1
    Human Genome Epidemiology (HuGE) Navigator: UGT3A1 (2 documents)

    Export disorders for UGT3A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT3A1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with UGT3A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Identification of residues that confer sugar selectivi ty to UDP-glycosyltransferase 3A (UGT3A) enzymes. (PubMed id 22621930)1 Meech R....Mackenzie P.I. (2012)
    5. UGT3A: novel UDP-glycosyltransferases of the UGT supe rfamily. (PubMed id 19814657)1 Meech R. and Mackenzie P.I. (2010)
    6. Identification of UDP glycosyltransferase 3A1 as a UDP N-acetylglucosaminyltransferase. (PubMed id 18981171)1 Mackenzie P.I....Meech R. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 133688 HGNC: 26625 AceView: FLJ34658 Ensembl:ENSG00000145626 euGenes: HUgn133688
    ECgene: UGT3A1 H-InvDB: UGT3A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT3A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGT3A1 gene:
    Search GeneIP for patents involving UGT3A1

    GeneCards and IP:
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