Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UGT2B7 Gene

Aliases for UGT2B7 Gene

  • UDP Glucuronosyltransferase Family 2 Member B7 2 3 5
  • 3,4-Catechol Estrogen-Specific UDPGT 3 4
  • UDP-Glucuronosyltransferase 2B9 3 4
  • EC 2.4.1.17 4 61
  • UDPGT 2B7 3 4
  • UDPGT 2B9 3 4
  • UDPGTh-2 3 4
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B7 3
  • UDP Glycosyltransferase 2 Family, Polypeptide B7 2
  • UDP-Glucuronyltransferase, Family 2, Beta-7 3
  • UDP-Glucuronosyltransferase 2B7 3
  • 3,4-Catechol Estrogen Specific 3
  • UDPGT2B7 3
  • UDPGTH2 3
  • UGTB2B9 4
  • UGT2B9 3

External Ids for UGT2B7 Gene

Previous GeneCards Identifiers for UGT2B7 Gene

  • GC04P069872
  • GC04P070010
  • GC04P070166
  • GC04P070277
  • GC04P070142
  • GC04P069962
  • GC04P069917
  • GC04P065757

Summaries for UGT2B7 Gene

Entrez Gene Summary for UGT2B7 Gene

  • The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]

GeneCards Summary for UGT2B7 Gene

UGT2B7 (UDP Glucuronosyltransferase Family 2 Member B7) is a Protein Coding gene. Diseases associated with UGT2B7 include Ugt2b7-Related Altered Drug Metabolism and Colon Adenoma. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B10.

UniProtKB/Swiss-Prot for UGT2B7 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

  • Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

Gene Wiki entry for UGT2B7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B7 Gene

Genomics for UGT2B7 Gene

Regulatory Elements for UGT2B7 Gene

Enhancers for UGT2B7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F069051 0.2 ENCODE 28 +0.3 317 0.7 HDGF DRAP1 PKNOX1 IKZF1 MLLT1 UGT2B7 LOC105377265
GH04F069053 0.9 Ensembl ENCODE 27.7 +5.8 5807 7.5 ELF3 TBP PKNOX1 ARID4B DMAP1 THRB RAD21 ZBTB40 RARA YY1 UGT2B7 UGT2B28 LOC105377267 UGT2A3 CSN1S1 LOC105377265 ENSG00000248763
GH04F069095 0.8 Ensembl ENCODE 13.7 +45.7 45713 3.8 ATF1 MLX ARID4B DMAP1 YY1 FOS MXD4 MIER2 PPARG KAT8 UGT2B7 UGT2B28 LOC105377267 UGT2A3 PIR54134 ENSG00000248763
GH04F069091 0.2 ENCODE 12.4 +41.0 41027 1.3 JUN NFE2 FOS UGT2B7 PIR54134 ENSG00000248763
GH04F068946 0.9 FANTOM5 ENCODE 10.8 -100.5 -100539 7.8 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 PAF1 SP5 MIER2 REST LOC105377267 UGT2B7 UGT2B28 UGT2A3 UGT2B11 UGT2B15 UGT2B10 LOC101927264
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UGT2B7 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2B7 Gene

Chromosome:
4
Start:
69,051,249 bp from pter
End:
69,112,987 bp from pter
Size:
61,739 bases
Orientation:
Plus strand

Genomic View for UGT2B7 Gene

Genes around UGT2B7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B7 Gene

Proteins for UGT2B7 Gene

  • Protein details for UGT2B7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16662-UD2B7_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B7
    Protein Accession:
    P16662
    Secondary Accessions:
    • B2R810
    • Q6GTW0

    Protein attributes for UGT2B7 Gene

    Size:
    529 amino acids
    Molecular mass:
    60695 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UGT2B7 Gene

neXtProt entry for UGT2B7 Gene

Post-translational modifications for UGT2B7 Gene

  • Glycosylation at Asn 67, Asn 68, and Asn 315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B7 Gene

Antibody Products

  • Abcam antibodies for UGT2B7
  • Santa Cruz Biotechnology (SCBT) Antibodies for UGT2B7

Domains & Families for UGT2B7 Gene

Gene Families for UGT2B7 Gene

Protein Domains for UGT2B7 Gene

Suggested Antigen Peptide Sequences for UGT2B7 Gene

Graphical View of Domain Structure for InterPro Entry

P16662

UniProtKB/Swiss-Prot:

UD2B7_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B7: view

Function for UGT2B7 Gene

Molecular function for UGT2B7 Gene

GENATLAS Biochemistry:
UDP glucuronosyltransferase subfamily 2,liver specific,but expressed in kidney,pancreas and brain,conjugating bile acid,potentially involved in the overall contribution of morphine analgesia
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
UniProtKB/Swiss-Prot Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

Enzyme Numbers (IUBMB) for UGT2B7 Gene

Gene Ontology (GO) - Molecular Function for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IEA,IDA 17442341
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B7: view
genes like me logo Genes that share phenotypes with UGT2B7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT2B7 Gene

Localization for UGT2B7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B7 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B7 Gene COMPARTMENTS Subcellular localization image for UGT2B7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 3
peroxisome 3
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,TAS 2159463
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with UGT2B7: view

Pathways & Interactions for UGT2B7 Gene

genes like me logo Genes that share pathways with UGT2B7: view

SIGNOR curated interactions for UGT2B7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA,TAS 2159463
GO:0008152 metabolic process IEA --
GO:0008202 steroid metabolic process IEA --
GO:0008209 androgen metabolic process IDA 17442341
GO:0009813 flavonoid biosynthetic process IBA --
genes like me logo Genes that share ontologies with UGT2B7: view

Drugs & Compounds for UGT2B7 Gene

(91) Drugs for UGT2B7 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist, Enzyme, substrate 74
Morphine Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate 960
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 939
Flurbiprofen Approved, Investigational Pharma Channel blocker, Enzyme, substrate 47
Valproic Acid Approved, Investigational Pharma Enzyme, substrate HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 322

(153) Additional Compounds for UGT2B7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Morphine-3-glucuronide
20290-09-9
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
(3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronate
  • (3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-beta-delta-Glucopyranosiduronate
  • Taurolithocholic acid 3-glucuronide
99794-82-8
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
(3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid
  • Glycocholic acid 3-glucuronide
99794-78-2
genes like me logo Genes that share compounds with UGT2B7: view

Transcripts for UGT2B7 Gene

Unigene Clusters for UGT2B7 Gene

UDP glucuronosyltransferase 2 family, polypeptide B7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B7 Gene

No ASD Table

Relevant External Links for UGT2B7 Gene

GeneLoc Exon Structure for
UGT2B7
ECgene alternative splicing isoforms for
UGT2B7

Expression for UGT2B7 Gene

mRNA expression in normal human tissues for UGT2B7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B7 Gene

This gene is overexpressed in Liver (x29.9) and Kidney - Cortex (x19.6).

Protein differential expression in normal tissues from HIPED for UGT2B7 Gene

This gene is overexpressed in Gallbladder (33.5), Liver (19.3), and Kidney (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGT2B7 Gene



Protein tissue co-expression partners for UGT2B7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UGT2B7 Gene:

UGT2B7

SOURCE GeneReport for Unigene cluster for UGT2B7 Gene:

Hs.654424
genes like me logo Genes that share expression patterns with UGT2B7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UGT2B7 Gene

Orthologs for UGT2B7 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B7 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 81 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt2b36 34 16
  • 74.46 (n)
Ugt2b35 35
  • 67 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b15 34
  • 74.35 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 72 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ugt86Da 36
  • 35 (a)
Ugt86Dg 36
  • 35 (a)
CG15661 36
  • 34 (a)
CG6475 36
  • 34 (a)
Ugt86Di 36
  • 34 (a)
Ugt86Dj 36
  • 34 (a)
CG11289 36
  • 33 (a)
Ugt86Dc 36
  • 33 (a)
Ugt35b 36
  • 32 (a)
BEST:GH06505 36
  • 31 (a)
BEST:GH09393 36
  • 31 (a)
Ugt37a1 36
  • 31 (a)
Ugt35a 36
  • 30 (a)
Ugt86Dd 36
  • 30 (a)
Ugt36Bc 36
  • 29 (a)
Ugt36Bb 36
  • 28 (a)
Ugt86De 36
  • 28 (a)
CG10178 36
  • 27 (a)
Ugt36Ba 36
  • 26 (a)
Ugt37b1 36
  • 26 (a)
CG10170 36
  • 25 (a)
CG17323 36
  • 25 (a)
CG5999 36
  • 25 (a)
Ugt86Dh 36
  • 25 (a)
CG10168 36
  • 23 (a)
CG5724 36
  • 23 (a)
Dot 36
  • 23 (a)
worm
(Caenorhabditis elegans)
Secernentea M88.1 36
  • 32 (a)
F39G3.1 36
  • 30 (a)
C03A7.11 36
  • 27 (a)
C08B6.1 36
  • 27 (a)
ZC443.5 36
  • 27 (a)
F35H8.6 36
  • 26 (a)
T25B9.7 36
  • 26 (a)
C10H11.4 36
  • 25 (a)
C33A12.6 36
  • 25 (a)
C44H9.1 36
  • 25 (a)
C08F11.8 36
  • 24 (a)
C10H11.5 36
  • 24 (a)
F01D4.1 36
  • 23 (a)
F56B3.7 36
  • 23 (a)
R04B5.9 36
  • 23 (a)
T01G5.2 36
  • 23 (a)
T03D3.1 36
  • 23 (a)
Y37E11AR.5 36
  • 23 (a)
T19H12.11 36
  • 22 (a)
F01D4.2 36
  • 21 (a)
Species where no ortholog for UGT2B7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B7 Gene

ENSEMBL:
Gene Tree for UGT2B7 (if available)
TreeFam:
Gene Tree for UGT2B7 (if available)

Paralogs for UGT2B7 Gene

Variants for UGT2B7 Gene

Sequence variations from dbSNP and Humsavar for UGT2B7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10006452 -- 69,112,090(+) CCCTG(C/T)GCCTG intron-variant
rs10008743 -- 69,112,190(+) tgttc(C/T)gttcc intron-variant
rs10014355 -- 69,059,607(+) ggact(C/G)gctgt intron-variant, nc-transcript-variant
rs10021748 -- 69,052,154(+) acatc(A/G)gaagg intron-variant
rs10022440 -- 69,108,008(+) TCAGT(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B7 Gene

Variant ID Type Subtype PubMed ID
dgv844e201 CNV deletion 23290073
esv2727775 CNV deletion 23290073
esv2759258 CNV gain+loss 17122850
esv3893952 CNV loss 25118596
nsv522091 CNV loss 19592680
nsv594582 CNV loss 21841781
nsv594583 CNV loss 21841781
nsv822595 CNV loss 20364138
nsv964059 CNV duplication 23825009
nsv999654 CNV gain 25217958

Variation tolerance for UGT2B7 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2B7 Gene

Human Gene Mutation Database (HGMD)
UGT2B7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2B7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B7 Gene

Disorders for UGT2B7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UGT2B7 Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ugt2b7-related altered drug metabolism
colon adenoma
  • adenomatous polyp of colon
hepatocellular adenoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT2B7

Genetic Association Database (GAD)
UGT2B7
Human Genome Epidemiology (HuGE) Navigator
UGT2B7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2B7
genes like me logo Genes that share disorders with UGT2B7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT2B7 Gene

Publications for UGT2B7 Gene

  1. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. (PMID: 11186130) Bhasker C.R. … Miners J.O. (Pharmacogenetics 2000) 3 4 22 46 64
  2. Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. (PMID: 19244109) Blevins-Primeau A.S. … Lazarus P. (Cancer Res. 2009) 3 22 46 64
  3. Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk. (PMID: 19352303) McGrath M. … De Vivo I. (Pharmacogenet. Genomics 2009) 3 22 46 64
  4. UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients. (PMID: 19494809) van Schaik R.H. … van Gelder T. (Clin. Pharmacol. Ther. 2009) 3 22 46 64
  5. Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. (PMID: 19628728) Kwara A. … Court M.H. (J Clin Pharmacol 2009) 3 22 46 64

Products for UGT2B7 Gene

Sources for UGT2B7 Gene

Content
Loading form....