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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UGT2B7 Gene

protein-coding GIFtS: 66
GCID: GC04P069917

UDP glucuronosyltransferase 2 family, polypeptide B7

(Previous names: UDP glycosyltransferase 2 family, polypeptide B7 )

Explore 19 diseases affiliated with
UGT2B7 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B7¹ ²		UDP Glycosyltransferase 2 Family, Polypeptide B7¹
UGT2B9¹ ² ⁵		3,4-Catechol Estrogen Specific²
3,4-Catechol Estrogen-Specific UDPGT² ³		UDPGT2B7²
UDPGTh-2² ³		UDPGTH2²
UDP-Glucuronosyltransferase 2B9² ³		UDP Glucuronosyltransferase 2B7²
UDPGT 2B7² ³		UDP-Glucuronosyltransferase 2B7²
UDPGT 2B9² ³		UDP-Glucuronyltransferase, Family 2, Beta-7²
EC 2.4.1.17³ ⁸		UGTB2B9³

External Ids:	HGNC: 12554¹	Entrez Gene: 7364²	Ensembl: ENSG00000171234⁷	OMIM: 600068⁵	UniProtKB: P16662³

Export aliases for UGT2B7 gene to outside databases

Previous GC identifers: GC04P069872 GC04P070010 GC04P070166 GC04P070277 GC04P070142 GC04P069962 GC04P065757

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGT2B7:

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the

conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is

localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting

that it may play an important role in regulating the level and activity of these potent estrogen metabolites.

(provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: UD2B7_HUMAN, P16662

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics

and endogenous compounds

Function: Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in

regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone,

hyodeoxycholic acid and tetrachlorocatechol (in vitro)

Gene Wiki entry for UGT2B7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022778.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UGT2B7 gene promoter:
HOXA9 HOXA9B C/EBPbeta AML1a C/EBPalpha FOXO1a Meis-1a Pax-4a Meis-1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UGT2B7 promoter sequence

Search SABiosciences Chromatin IP Primers for UGT2B7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2B7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13 Ensembl cytogenetic band: 4q13.2 HGNC cytogenetic band: 4q13

UGT2B7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B7 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P069917: view genomic region (about GC identifiers)

Start:	69,917,081 bp from pter	End:	69,978,705 bp from pter
Size:	61,625 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UD2B7_HUMAN, P16662 (See protein sequence)

Recommended Name: UDP-glucuronosyltransferase 2B7 precursor

Size: 529 amino acids; 60695 Da

Subcellular location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane;

Single-pass membrane protein (Potential)

1 PDB 3D structure from and Proteopedia for UGT2B7:

2O6L (3D)

Secondary accessions: B2R810 Q6GTW0

Explore the universe of human proteins at neXtProt for UGT2B7: NX_P16662

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16662

4/32 DME Specific Peptides for UGT2B7 (P16662) (see all 32)

DLLNALK

AFITHGG

MTFMERV

CGKVLVW

UGT2B7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001065.2

ENSEMBL proteins:

ENSP00000426206 ENSP00000304811 ENSP00000427659

Reactome Protein details: P16662
Human Recombinant Protein Products:

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	Uscn Proteins for UGT2B7

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	--	--
GO:0016020	membrane	TAS	2159463
GO:0016021	integral to membrane	IEA	--

UGT2B7 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for UGT2B7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UGT2B7 for domains About GeneDecksing

1 InterPro domain/family:

IPR002213 UDP_glucos_trans

Graphical View of Domain Structure for InterPro Entry P16662

ProtoNet protein and cluster: P16662

1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

UniProtKB/Swiss-Prot: UD2B7_HUMAN, P16662

Similarity: Belongs to the UDP-glycosyltransferase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UD2B7_HUMAN, P16662

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics

and endogenous compounds

Function: Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in

regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone,

hyodeoxycholic acid and tetrachlorocatechol (in vitro)

Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

Genatlas biochemistry entry for UGT2B7:

UDP glucuronosyltransferase subfamily 2,liver specific,but expressed in kidney,pancreas and brain,conjugating bile

acid,potentially involved in the overall contribution of morphine analgesia

Enzyme Number (IUBMB): EC 2.4.1.17¹ ²

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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UGT2B7

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001972	NOT retinoic acid binding	IDA	--
GO:0015020	glucuronosyltransferase activity	IDA	--
GO:0016758	transferase activity, transferring hexosyl groups	--	--

UGT2B7 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glucuronidation

Glucuronidation	1.00	Porphyrin and chlorophyll metabolism	0.38
Glucuronidation	0.67	Other types of O-glycan biosynthesis	0.36
Starch and sucrose metabolism	0.42	Drug metabolism - other enzymes	0.32

Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics

	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics	1.00			Statin Pathway - Generalized, Pharmacokinetics	0.70
	Fluvastatin Pathway, Pharmacokinetics	0.80

Codeine and morphine metabolism

	Codeine and morphine metabolism	1.00			Tramadol Pharmacokinetics	0.36
	Codeine and Morphine Pathway, Pharmacokinetics	0.89

Tamoxifen metabolism

	Tamoxifen metabolism	1.00			Benzodiazepine Pathway, Pharmacokinetics	0.30
	Tamoxifen Pathway, Pharmacokinetics	0.68

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for UGT2B7

Retinol metabolism

1 GeneGo (Thomson Reuters) Pathway for UGT2B7

Retinol metabolism

5 BioSystems Pathways for UGT2B7

	Codeine and morphine metabolism
	Glucuronidation
	Estrogen metabolism
	Tamoxifen metabolism
	metapathway biotransformation

4 Reactome Pathways for UGT2B7

	Metabolism
	Biological oxidations
	Phase II conjugation
	Glucuronidation

5/15 PharmGKB Pathways for UGT2B7 (see all 15)

	Artemisinin and Derivatives Pathway, Pharmacokinetics
	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Benzodiazepine Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Codeine and Morphine Pathway, Pharmacokinetics

5/11 Kegg Pathways (Kegg details for UGT2B7) (see all 11):

	Pentose and glucuronate interconversions
	Ascorbate and aldarate metabolism
	Steroid hormone biosynthesis
	Starch and sucrose metabolism
	Other types of O-glycan biosynthesis

UGT2B7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UGT2B7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for UGT2B7 (P16662³ ENSP00000304811⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP3A4	P08684³, ENSP00000337915⁴	I2D: score=1 STRING: ENSP00000337915
ADH4	ENSP00000265512⁴	STRING: ENSP00000265512
AKR1C4	ENSP00000263126⁴	STRING: ENSP00000263126
COMT	ENSP00000354511⁴	STRING: ENSP00000354511
CYP1A1	ENSP00000369050⁴	STRING: ENSP00000369050

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	2159463
GO:0008209	androgen metabolic process	IDA	17442341
GO:0052695	cellular glucuronidation	IDA	--

UGT2B7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UGT2B7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UGT2B7

10/86 HMDB Compounds for UGT2B7 (see all 86) About this table

Compound	Synonyms	CAS #	PubMed Ids
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid	Ibuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)	115075-59-7	15843492
Aldosterone 18-glucuronide	Aldosterone-18-D-glucosiduronic acid (see all 6)	3604-86-2	12746330
Androsterone	(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)	53-41-8	9443856
Ethyl glucuronide		17685-04-0	16139098
Hydroxycotinine	(3R-trans)-3-hydroxy-1-methyl-5-(3-pyridinyl)-2-Pyrrolidinone (see all 5)	34834-67-8	15470160
Ketoprofen glucuronide	1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)	76690-94-3	15843492
Nicotine glucuronide	(S)-1-alpha-D-glucopyranuronosyl-3-(1-methyl-2-pyrrolidinyl)-Pyridinium inner salt (see all 11)	152306-59-7	17576790
Retinoyl b-glucuronide	13-cis-Retinoyl glucuronide (see all 21)	401-10-5	11943730
Retinyl beta-glucuronide	Retinyl b-glucuronide (see all 2)	--	8600986
Tetrahydroaldosterone-3-glucuronide	Tetrahydroaldosterone-3-glucuronoside (see all 6)	20605-81-6	12746330

10/17 DrugBank Compounds for UGT2B7 (see all 17) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Morphine	(-)-Heroin hydrochloride (see all 12)	57-27-2	enzyme	substrate	15611481 20071451 14746343 9010622
Epirubicin	--	56420-45-2	enzyme	substrate	11302935 16985101
Ezetimibe	--	163222-33-1	enzyme	substrate	14977865 15871634
Indomethacin	IMN (see all 9)	53-86-1	enzyme	substrate inhibitor	17200831 17245571
Mycophenolic acid	--	24280-93-1	enzyme	substrate	21123165 15470161
Chenodeoxycholic acid	Chenocholic acid (see all 3)	474-25-9	enzyme	inhibitor	15821044
Diclofenac	Diclofenac Acid (see all 4)	15307-86-5	enzyme	substrate	19515014
Etodolac	--	41340-25-4	enzyme	substrate	19515014
Flunitrazepam	--	1622-62-4	enzyme	inhibitor	2119476
Flurbiprofen	FLP (see all 5)	5104-49-4	enzyme	substrate	19515014

10/58 Novoseek chemical compound relationships for UGT2B7 gene (see all 58) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
uridine diphosphate	86.2	4	18161889 (1), 12201491 (1), 17998299 (1), 19644937 (1)
udp glucuronic acid	85.8	4	17442341 (2), 12485951 (2)
morphine-3-glucuronide	81.8	5	15611481 (1), 11186135 (1), 18622261 (1), 9010622 (1) (see all 5)
glucuronide	81.5	7	11302935 (1), 16518089 (1), 17359941 (1), 11560872 (1) (see all 6)
hecogenin	81.1	1	17998299 (1)
4-hydroxyestrone	78.3	3	11943730 (3)
glucuronic acid	74.3	5	17442341 (1), 19224506 (1), 12527334 (1), 15472229 (1) (see all 5)
mycophenolic acid	71.9	32	17211619 (7), 17339869 (3), 18641546 (2), 19730281 (2) (see all 10)
morphine 6-glucuronide	69.6	2	12811366 (1), 9010622 (1)
4-methylumbelliferone	67.6	10	17237258 (2), 19850672 (1), 18647858 (1)

3 PharmGKB related drug/compound annotations for UGT2B7 gene

Drug/compound	PharmGKB Annotation
efavirenz	CA
lorazepam	CA
valproic acid	CA

About this table

Search CenterWatch for drugs/clinical trials and news about UGT2B7 / UD2B7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UGT2B7 gene:

NM_001074.2

Unigene Cluster for UGT2B7:

UDP glucuronosyltransferase 2 family, polypeptide B7

Hs.654424 [show with all ESTs]

Unigene Representative Sequence: NM_001074

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000502942 ENST00000509763 ENST00000305231(uc003heg.4 uc010ihq.3)

ENST00000508661

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT2B7

Additional cDNA sequence:

AK223142.1 AK313190.1 BC030974.1 J05428.1 S82485.1

7 DOTS entries:

DT.211670 DT.91760200 DT.121271578 DT.99998740 DT.100814506 DT.95149614 DT.95372475

24/138 AceView cDNA sequences (see all 138):

BF105272 AA962194 AI872480 AW614236 BE302682 AI381747 BF434817 BE890984

BF594690 BC030974 AI436193 CB138188 BG190743 BC007238 CB139290 BG427192

AI280530 CB147253 AI925907 AI783649 BQ652365 AI769988 BG427877 BF689099

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UGT2B7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTAGAAATA

About this image

UGT2B7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Mesendoderm (Derivation and sorti...)

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UGT2B7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UGT2B7

SOURCE GeneReport for Unigene cluster: Hs.654424

SABiosciences Expression via Pathway-Focused PCR Array including UGT2B7:

Drug Metabolism: Phase II Enzymes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT2B7 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT2B7

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UGT2B7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for UGT2B7 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NMB3_CHICK⁶	Uncharacterized protein	57(a)	1 → many	4(53288491-53295396)
lizard (Anolis carolinensis)	Reptilia	-- --	--	55(a) 55(a)	many ↔ many many ↔ many	6(58629882-58649612) 6(58564243-58578541)
zebrafish (Danio rerio)	Actinopterygii	BX571679.1⁶ FP236810.4⁶ (see all 15)	--	65(a) 53(a) (see all 15)	many ↔ many many ↔ many (see all 15)	5(9986135-9988976) 5(9898582-9908402)
fruit fly (Drosophila melanogaster)	Insecta	Ugt86Da³ CG6475¹	glucuronosyltransferase³ CG6475¹	35(a) (best of 27)³ 48.33(n)¹ 34.55(a)¹		86D7³ 42538¹ NM_001104389.3¹ NP_001097859.3¹

ENSEMBL Gene Tree for UGT2B7 (if available)
TreeFam Gene Tree for UGT2B7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for UGT2B7 gene

UGT2A2² UGT1A8² UGT1A7² UGT3A1² UGT2B11² UGT1A3² UGT1A1² UGT1A5²

UGT3A2² UGT2B10² UGT1A10² UGT1A6² UGT8² UGT2B15² UGT2B4² UGT2B17²

UGT2A3² UGT2B28² UGT1A9² UGT1A4²

18/30 SIMAP similar genes for UGT2B7 using alignment to 6 protein entries: UD2B7_HUMAN (see all proteins) (see all similar genes):

UGT2B4 UGT2B11 UGT2B28 UGT2B17 UGT2B15 UGT2B10

UGT1A3S UGT1A9S UGT2A3 UGT1A8S UGT2A1 UGT1A4S

UGT1A6S UGT1A6 UGT3A2 UGT1A10 UGT8 BILIQTL1

UGT2B7 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for UGT2B7
PGOHUM00000245568 PGOHUM00000245583 PGOHUM00000250776 PGOHUM00000250780 PGOHUM00000245957

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UGT2B7
1 CNV: 3499
Human Gene Mutation Database (HGMD): UGT2B7

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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UGT2B7 for disorders           About GeneDecksing

OMIM gene information: 600068    OMIM disorders: --

19 diseases for UGT2B7:    About MalaCards

familial adenomatous polyposis hearing loss sickle cell disease polyposis

diabetes mellitus breast cancer duodenitis endometrial cancer

liver disease glomerulonephritis prostate carcinoma colorectal cancer

prostatitis prostate cancer adenoma hepatitis

carcinoma cholesterol alcoholism

6 Novoseek disease relationships for UGT2B7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis autoimmune	17.6	1	11343231 (1)
bladder cancer	13.9	4	15615884 (2), 18569595 (1)
breast cancer	6.19	3	11943730 (2), 19289110 (1)
cancer	5.02	6	12629580 (2), 12695358 (1), 15001974 (1)
tumors	1.06	1	15318931 (1)
carcinoma	0	1	11943730 (1)

Genetic Association Database (GAD): UGT2B7
Human Genome Epidemiology (HuGE) Navigator: UGT2B7 (68 documents)

Export disorders for UGT2B7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for UGT2B7 gene, integrated from 9 sources (see all 248):
(articles sorted by number of sources associating them with UGT2B7)

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Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. (PubMed id 11186130)^{1, 2, 4, 9} Bhasker C.R....Miners J.O. (2000)
Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates. (PubMed id 2159463)^{1, 2, 3} Ritter J.K.... Owens I.S. (1990)
Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (PubMed id 15319348)^{1, 4, 9} Saeki M....Sawada J. (2004)
Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. (PubMed id 15611481)^{1, 7, 9} Takeda S....Yamada H. (2005)
Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. (PubMed id 12629580)^{1, 4, 9} Holthe M....Skorpen F. (2003)
Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. (PubMed id 17442341)^{1, 2, 9} Miley M.J....Redinbo M.R. (2007)
An association of UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine-exposed workers in China. (PubMed id 15615884)^{1, 4, 9} Lin G.F....Shen J.H. (2005)
Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites. (PubMed id 12746330)^{1, 6, 9} Girard C....Belanger A. (2003)
Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. (PubMed id 16397224)^{1, 4, 9} Thibaudeau J....Guillemette C. (2006)
Clinical response to morphine in cancer patients and genetic variation in candidate genes. (PubMed id 16103897)^{1, 4, 9} Ross J.R....Riley J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7364	HGNC: 12554	AceView: UGT2B7	Ensembl:ENSG00000171234	euGenes: HUgn7364
ECgene: UGT2B7	Kegg: 7364	H-InvDB: UGT2B7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for UGT2B7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UGT2B7 gene
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Patent Information for UGT2B7 gene:
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UGT2B7 Gene

UDP glucuronosyltransferase 2 family, polypeptide B7

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UGT2B7 Gene

UDP glucuronosyltransferase 2 family, polypeptide B7

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