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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT2B7 Gene

protein-coding   GIFtS: 67
GCID: GC04P069917

UDP Glucuronosyltransferase 2 Family, Polypeptide B7

(Previous names: UDP glycosyltransferase 2 family, polypeptide B7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B71 2     UDP Glycosyltransferase 2 Family, Polypeptide B71
3,4-Catechol Estrogen-Specific UDPGT2 3     3,4-Catechol Estrogen Specific2
UDPGTh-22 3     UDPGT2B72
UDP-Glucuronosyltransferase 2B92 3     UDPGTH22
UDPGT 2B72 3     UDP Glucuronosyltransferase 2B72
UDPGT 2B92 3     UDP-Glucuronosyltransferase 2B72
EC 2.4.1.173 8     UDP-Glucuronyltransferase, Family 2, Beta-72
UGT2B92 5     UGTB2B93

External Ids:    HGNC: 125541   Entrez Gene: 73642   Ensembl: ENSG000001712347   OMIM: 6000685   UniProtKB: P166623   

Export aliases for UGT2B7 gene to outside databases

Previous GC identifers: GC04P069872 GC04P070010 GC04P070166 GC04P070277 GC04P070142 GC04P069962 GC04P065757


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGT2B7 Gene:
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in
the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This
protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and
estriol, suggesting that it may play an important role in regulating the level and activity of these potent
estrogen metabolites. (provided by RefSeq, Sep 2011)

GeneCards Summary for UGT2B7 Gene: 
UGT2B7 (UDP glucuronosyltransferase 2 family, polypeptide B7) is a protein-coding gene. Diseases associated with UGT2B7 include hepatocellular adenoma, and hiv/aids, and among its related super-pathways are Ascorbate and aldarate metabolism and Codeine and Morphine Pathway, Pharmacokinetics. GO annotations related to this gene include retinoic acid binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD2B7_HUMAN, P16662
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds
Function: Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in
regulating the level and activity of these potent and active estrogen metabolites. Is also active with
androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro)

Gene Wiki entry for UGT2B7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT2B7 gene promoter:
         HOXA9   HOXA9B   C/EBPbeta   AML1a   C/EBPalpha   FOXO1a   Meis-1a   Pax-4a   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGT2B7 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGT2B7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2B7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13

UGT2B7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P069917:  view genomic region     (about GC identifiers)

Start:
69,917,081 bp from pter      End:
69,978,705 bp from pter
Size:
61,625 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UD2B7_HUMAN, P16662 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2B7 precursor  
Size: 529 amino acids; 60695 Da
Subcellular location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum
membrane; Single-pass membrane protein (Potential)
1 PDB 3D structure from and Proteopedia for UGT2B7:
2O6L (3D)    
Secondary accessions: B2R810 Q6GTW0

Explore the universe of human proteins at neXtProt for UGT2B7: NX_P16662

Explore proteomics data for UGT2B7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16662

  • 4/32 DME Specific Peptides for UGT2B7 (P16662) (see all 32)
     DLLNALK  AFITHGG  MTFMERV  CGKVLVW 

    UGT2B7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGT2B7 Protein Expression
    REFSEQ proteins: NP_001065.2  
    ENSEMBL proteins: 
     ENSP00000426206   ENSP00000304811   ENSP00000427659  
    Reactome Protein details: P16662
    Human Recombinant Protein Products for UGT2B7: 
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    Cloud-Clone Corp. Proteins for UGT2B7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane TAS2159463
    GO:0016021integral to membrane IEA--

    UGT2B7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P16662

    ProtoNet protein and cluster: P16662

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD2B7_HUMAN, P16662
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT2B7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD2B7_HUMAN, P16662
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds
    Function: Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in
    regulating the level and activity of these potent and active estrogen metabolites. Is also active with
    androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro)
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Genatlas biochemistry entry for UGT2B7:
    UDP glucuronosyltransferase subfamily 2,liver specific,but expressed in kidney,pancreas and brain,conjugating bile
    acid,potentially involved in the overall contribution of morphine analgesia

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972NOT retinoic acid binding IDA--
    GO:0015020glucuronosyltransferase activity IDA17442341
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    UGT2B7 for ontologies           About GeneDecksing


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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2B7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UGT2B7 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.67
    Starch and sucrose metabolism0.41
    Glucuronidation0.67
    Porphyrin and chlorophyll metabolism0.38
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.33
    Pentose and glucuronate interconversions0.61
    Steroid hormone biosynthesis0.30
    2Codeine and morphine metabolism
    Codeine and morphine metabolism0.89
    Tramadol Pharmacokinetics0.36
    Codeine and Morphine Pathway, Pharmacokinetics0.89
    3Tamoxifen metabolism
    Tamoxifen metabolism0.68
    Benzodiazepine Pathway, Pharmacokinetics0.38
    Tamoxifen Pathway, Pharmacokinetics0.68
    4Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    5Estrogen metabolism
    Estrogen metabolism0.43
    Estrogen Metabolism Pathway0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UGT2B7
        Retinol metabolism


    1 GeneGo (Thomson Reuters) Pathway for UGT2B7
        Retinol metabolism

    5 BioSystems Pathways for UGT2B7
        Glucuronidation
    Codeine and morphine metabolism
    Tamoxifen metabolism
    Estrogen metabolism
    metapathway biotransformation

    4        Reactome Pathways for UGT2B7
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation

    5/16 PharmGKB Pathways for UGT2B7 (see all 16)
        Artemisinin and Derivatives Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Carbamazepine Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics

    5/11         Kegg Pathways  (Kegg details for UGT2B7) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT2B7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT2B7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for UGT2B7 (P166623 ENSP000003048114) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP3A4P086843, ENSP000003379154I2D: score=1 STRING: ENSP00000337915
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    COMTENSP000003545114STRING: ENSP00000354511
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006629lipid metabolic process TAS2159463
    GO:0008152metabolic process ----
    GO:0008209androgen metabolic process IDA17442341
    GO:0030259lipid glycosylation ----

    UGT2B7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT2B7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UGT2B7 (UD2B7)

    10/86 HMDB Compounds for UGT2B7 (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-715843492
    Aldosterone 18-glucuronideAldosterone-18-D-glucosiduronic acid (see all 6)3604-86-212746330
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-89443856
    Ethyl glucuronide 17685-04-016139098
    Hydroxycotinine(3R-trans)-3-hydroxy-1-methyl-5-(3-pyridinyl)-2-Pyrrolidinone (see all 5)34834-67-815470160
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-315843492
    Nicotine glucuronide(S)-1-alpha-D-glucopyranuronosyl-3-(1-methyl-2-pyrrolidinyl)-Pyridinium inner salt (see all 11)152306-59-717576790
    Retinoyl b-glucuronide13-cis-Retinoyl glucuronide (see all 21)401-10-511943730
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    Tetrahydroaldosterone-3-glucuronideTetrahydroaldosterone-3-glucuronoside (see all 6)20605-81-612746330

    10/30 DrugBank Compounds for UGT2B7 (see all 30)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Morphine(-)-Heroin hydrochloride (see all 12)57-27-2enzymesubstrate15611481 20071451 14746343 9010622
    Epirubicin-- 56420-45-2enzymesubstrate11302935 16985101
    Ezetimibe-- 163222-33-1enzymesubstrate14977865 15871634
    Flunitrazepam-- 1622-62-4enzymeinhibitor9848110 2119476
    IndomethacinIMN (see all 9)53-86-1enzymesubstrate inhibitor17200831 17245571
    Mycophenolic acid-- 24280-93-1enzymesubstrate21123165 15470161
    CarbamazepineCarbamezepine (see all 3)298-46-4enzymesubstrate15915352
    Chenodeoxycholic acidChenocholic acid (see all 3)474-25-9enzymeinhibitor15821044
    Dabigatran etexilateDabigatran (see all 2)211915-06-9enzyme--20551237
    DiclofenacDiclofenac Acid (see all 4)15307-86-5enzymesubstrate19515014

    10/58 Novoseek inferred chemical compound relationships for UGT2B7 gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uridine diphosphate 86.2 4 18161889 (1), 12201491 (1), 17998299 (1), 19644937 (1)
    udp glucuronic acid 85.8 4 17442341 (2), 12485951 (2)
    morphine-3-glucuronide 81.8 5 15611481 (1), 11186135 (1), 18622261 (1), 9010622 (1) (see all 5)
    glucuronide 81.5 7 11302935 (1), 16518089 (1), 17359941 (1), 11560872 (1) (see all 6)
    hecogenin 81.1 1 17998299 (1)
    4-hydroxyestrone 78.3 3 11943730 (3)
    glucuronic acid 74.3 5 17442341 (1), 19224506 (1), 12527334 (1), 15472229 (1) (see all 5)
    mycophenolic acid 71.9 32 17211619 (7), 17339869 (3), 18641546 (2), 19730281 (2) (see all 10)
    morphine 6-glucuronide 69.6 2 12811366 (1), 9010622 (1)
    4-methylumbelliferone 67.6 10 17237258 (2), 19850672 (1), 18647858 (1)

    3 PharmGKB related drug/compound annotations for UGT2B7 gene    About this table
    Drug/compound PharmGKB Annotation
    efavirenzCA  
    lorazepamCA  
    valproic acidCA  

    Search CenterWatch for drugs/clinical trials and news about UGT2B7 / UD2B7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGT2B7 gene: 
    NM_001074.2  

    Unigene Cluster for UGT2B7:

    UDP glucuronosyltransferase 2 family, polypeptide B7
    Hs.654424  [show with all ESTs]
    Unigene Representative Sequence: NM_001074
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502942 ENST00000509763 ENST00000305231(uc003heg.4 uc010ihq.3)
    ENST00000508661
    miRNA
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    Additional mRNA sequence: 

    AK223142.1 AK313190.1 BC030974.1 J05428.1 S82485.1 

    7 DOTS entries:

    DT.211670  DT.91760200  DT.121271578  DT.99998740  DT.100814506  DT.95149614  DT.95372475 

    24/138 AceView cDNA sequences (see all 138):

    CB139290 BG190743 AW614236 BE890984 BF105272 BC007238 BG427192 BF434817 
    AI280530 BE302682 BC030974 BF594690 AI872480 AI381747 AA962194 CB138188 
    AI436193 BG219293 BM925650 AW779660 AI732855 AI769988 AI912999 BG220760 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT2B7 expression in normal human tissues (normalized intensities)      UGT2B7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAGAAATA
    UGT2B7 Expression
    About this image


    UGT2B7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Human Renal Mesangial Cells (HRMC)   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Renal Epithelial Cells (HREpiC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor E68
     
     Smooth Muscle (Muscoskeletal System)
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem ES-209, Meso-prx/latp Progenitor

    See UGT2B7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT2B7

    SOURCE GeneReport for Unigene cluster: Hs.654424
        SABiosciences Expression via Pathway-Focused PCR Array including UGT2B7: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UGT2B7 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt2b355
    Ugt2b361
    UDP glucuronosyltransferase 2 family, polypeptide B355
    UDP glucuronosyltransferase 2 family, polypeptide B361
    74.46(n)1
    67.49(a)1
      5 (43.56 cM)5
    2313961  NM_001029867.11  NP_001025038.11 
     870008605 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ugt86Da3
    CG64751
    glucuronosyltransferase3
    CG64751
    35(a)
    (best of 27)3
    48.33(n)1
    34.55(a)1
      86D73
    425381  NM_001104389.31  NP_001097859.31 


    ENSEMBL Gene Tree for UGT2B7 (if available)
    TreeFam Gene Tree for UGT2B7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT2B7 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT1A32  UGT1A12  UGT3A22  
    UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    18/30 SIMAP similar genes for UGT2B7 using alignment to 6 protein entries:     UD2B7_HUMAN (see all proteins) (see all similar genes):
    UGT2B4    UGT2B11    UGT2B28    UGT2B17    UGT2B15    UGT2B10
    UGT1A3S    UGT1A9S    UGT2A3    UGT1A8S    UGT2A1    UGT1A4S
    UGT1A6S    UGT1A6    UGT3A2    UGT1A10    UGT8    BILIQTL1

    UGT2B7 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for UGT2B7
    PGOHUM00000245568 PGOHUM00000245583 PGOHUM00000250776 PGOHUM00000250780 PGOHUM00000245957


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/482 SNPs in UGT2B7 are shown (see all 482)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs666037291,2
    C--69863477(+) ATTTT-/A/AA  
            
    AAAAA
    1 -- int12NA CSA 4
    rs1166047661,2
    F--69960206(+) ATGCTA/GTAGCA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs622969441,2
    C,F--69960210(+) TATAGT/CATATT 1 -- us2k18Minor allele frequency- C:0.32WA NA CSA EA 366
    rs1851188811,2
    --69960274(+) TTAATA/TGCTAA 1 -- us2k10--------
    rs1900668881,2
    --69960294(+) ATGATA/CATCTG 1 -- us2k10--------
    rs1449098151,2
    --69960349(+) AATGTC/TGATGG 1 -- us2k10--------
    rs66008791,2
    C,F,A--69960387(+) tagtaG/Cttagc 1 -- us2k113Minor allele frequency- C:0.33EA NA WA CSA 583
    rs66008801,2
    C,F,A--69960480(+) tagcaA/Tgcaat 1 -- us2k111Minor allele frequency- T:0.33NA WA CSA EA 505
    rs1814553161,2
    --69960526(+) TTTCAA/TAATTG 1 -- us2k10--------
    rs1490331731,2
    --69960547(+) TCTCAA/GACTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UGT2B7 (69917081 - 69978705 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for UGT2B7 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv891e201CNV Deletion23290073
    esv2727775CNV Deletion23290073
    nsv522091CNV Loss19592680
    nsv822595CNV Loss20364138
    nsv879379CNV Loss21882294
    dgv5608n71CNV Loss21882294
    essv17788CNV CNV17122850
    dgv1628e1CNV Complex17122850
    dgv1635e1CNV Complex17122850
    dgv1634e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): UGT2B7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT2B7
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT2B7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600068    OMIM disorders: --

    16 diseases for UGT2B7:    About MalaCards
    hepatocellular adenoma    hiv/aids    sickle cell disease    familial adenomatous polyposis
    duodenitis    cytochrome p450    glomerulonephritis    liver disease
    alcoholism    diabetes mellitus    prostatitis    adenoma
    breast cancer    hepatitis    colorectal cancer    prostate cancer


    UGT2B7 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for UGT2B7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis autoimmune 17.6 1 11343231 (1)
    bladder cancer 13.9 4 15615884 (2), 18569595 (1)
    breast cancer 6.19 3 11943730 (2), 19289110 (1)
    cancer 5.02 6 12629580 (2), 12695358 (1), 15001974 (1)
    tumors 1.06 1 15318931 (1)
    carcinoma 0 1 11943730 (1)

    Genetic Association Database (GAD): UGT2B7
    Human Genome Epidemiology (HuGE) Navigator: UGT2B7 (68 documents)

    Export disorders for UGT2B7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT2B7 gene, integrated from 9 sources (see all 265):
    (articles sorted by number of sources associating them with UGT2B7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. (PubMed id 11186130)1, 2, 4, 9 Bhasker C.R....Miners J.O. (2000)
    2. Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates. (PubMed id 2159463)1, 2, 3 Ritter J.K.... Owens I.S. (1990)
    3. Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (PubMed id 15319348)1, 4, 9 Saeki M....Sawada J. (2004)
    4. Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. (PubMed id 15611481)1, 7, 9 Takeda S....Yamada H. (2005)
    5. Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. (PubMed id 12629580)1, 4, 9 Holthe M....Skorpen F. (2003)
    6. Genetic polymorphisms of MRP2 and UGT2B7 and gastroin testinal symptoms in renal transplant recipients taking mycophenolic acid. (PubMed id 19730281)1, 4, 9 Yang J.W....Min D.I. (2009)
    7. AcylMPAG plasma concentrations and mycophenolic acid-related side effects in patients undergoing renal transplantation are not related to the UGT2B7-840G>A gene polymorphism. (PubMed id 18641546)1, 4, 9 van Agteren M....van Gelder T. (2008)
    8. Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations. (PubMed id 17115150)1, 4, 9 Mehlotra R.K....Zimmerman P.A. (2007)
    9. CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are p redictors of efavirenz mid-dose concentration in HIV-infected patients. (PubMed id 19779319)1, 4, 9 Kwara A....Court M.H. (2009)
    10. The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers. (PubMed id 17339869)1, 4, 9 Levesque E....Guillemette C. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7364 HGNC: 12554 AceView: UGT2B7 Ensembl:ENSG00000171234 euGenes: HUgn7364
    ECgene: UGT2B7 Kegg: 7364 H-InvDB: UGT2B7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT2B7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGT2B7 gene:
    Search GeneIP for patents involving UGT2B7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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