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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT2B4 Gene

protein-coding   GIFtS: 60
GCID: GC04M070345

UDP glucuronosyltransferase 2 family, polypeptide B4

(Previous names: UDP glycosyltransferase 2 family, polypeptide B4 )
 Explore 15 diseases affiliated with
UGT2B4 via our new
 Human Malady Compendium 
Biological research products
for UGT2B4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B41 2     UDP Glycosyltransferase 2 Family, Polypeptide B41
UGT2B111 2 3 5     UDPGT2B42
Hyodeoxycholic Acid-Specific UDPGT2 3     UDPGTH12
HLUG252 3     Hyodeoxycholic Acid2
UDPGTh-12 3     UDP Glucuronosyltransferase 2B42
UDPGT 2B42 3     UDP-Glucuronosyltransferase 2B42
EC 2.4.1.173 8     UDP-Glucuronyltransferase, Family 2, Beta-42

External Ids:    HGNC: 125531   Entrez Gene: 73632   Ensembl: ENSG000001560967   OMIM: 6000675   UniProtKB: P061333   

Export aliases for UGT2B4 gene to outside databases

Previous GC identifers: GC04P070172 GC04M070394 GC04M070595 GC04M070661 GC04M070186 GC04M070526 GC04M066144


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UD2B4_HUMAN, P06133
Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and
2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol,
4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

Gene Wiki entry for UGT2B4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT2B4 gene promoter:
         LUN-1   HNF-4alpha1   Gfi-1   PPAR-alpha   PPAR-gamma1   FOXO1a   PPAR-gamma2   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UGT2B4 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGT2B4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2B4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13

UGT2B4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M070345:  view genomic region     (about GC identifiers)

Start:
70,345,883 bp from pter      End:
70,391,732 bp from pter
Size:
45,850 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UD2B4_HUMAN, P06133 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2B4 precursor  
Size: 528 amino acids; 60513 Da
Subcellular location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane;
Single-pass membrane protein (Potential)
Caution: PubMed:8333863 thought that this was a new form (UGT2B11). The name UGT2B11 has now been reused for another
human enzyme
Secondary accessions: O60731 O60867 O75614 P36538 Q1HBF9

Explore the universe of human proteins at neXtProt for UGT2B4: NX_P06133

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P06133

  • 4/30 DME Specific Peptides for UGT2B4 (P06133) (see all 30)
     DLLNALK  AFITHGG  CGKVLVW  LLGHPKT 

    UGT2B4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066962.2  
    ENSEMBL proteins: 
     ENSP00000421290   ENSP00000305221   ENSP00000421113   ENSP00000370486  
    Reactome Protein details: P06133
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    Uscn Proteins for UGT2B4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--
    GO:0043231intracellular membrane-bounded organelle NAS--


    UGT2B4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UGT2B4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P06133

    ProtoNet protein and cluster: P06133

    1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD2B4_HUMAN, P06133
    Similarity: Belongs to the UDP-glycosyltransferase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: UD2B4_HUMAN, P06133
    Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
    and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and
    2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol,
    4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Genatlas biochemistry entry for UGT2B4:
    UDP glucuronosyltransferase 2,liver,bile acid conjugating

    Enzyme Number (IUBMB): EC 2.4.1.171 2

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972NOT retinoic acid binding IDA--
    GO:0015020glucuronosyltransferase activity IDA--
    GO:0016758transferase activity, transferring hexosyl groups ----


    UGT2B4 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    Glucuronidation1.00
    Porphyrin and chlorophyll metabolism0.38
    Glucuronidation0.67
    Other types of O-glycan biosynthesis0.36
    Starch and sucrose metabolism0.42
    Drug metabolism - other enzymes0.32
    2Drug metabolism - cytochrome P450
    Drug metabolism - cytochrome P4501.00
    Retinol metabolism0.40
    Metabolism of xenobiotics by cytochrome P4500.73
    3Biological oxidations
    Biological oxidations1.00
    metapathway biotransformation0.41
    Phase II conjugation0.52
    4Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    5Pentose and glucuronate interconversions
    Pentose and glucuronate interconversions1.00
    Ascorbate and aldarate metabolism0.62

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for UGT2B4 
        Glucuronidation
    metapathway biotransformation

    4        Reactome Pathways for UGT2B4
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation

    1 PharmGKB Pathway for UGT2B4
        Benzodiazepine Pathway, Pharmacokinetics

    5/12         Kegg Pathways  (Kegg details for UGT2B4) (see all 12):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Other types of O-glycan biosynthesis


    UGT2B4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT2B4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for UGT2B4 (ENSP000003052214) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    CES2ENSP000003178424STRING: ENSP00000317842
    COMTENSP000003545114STRING: ENSP00000354511
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006711estrogen catabolic process IDA8333863
    GO:0006805xenobiotic metabolic process IDA8333863
    GO:0008152metabolic process IDA8333863
    GO:0052695cellular glucuronidation IDA--


    UGT2B4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT2B4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UGT2B4

    10/86 HMDB Compounds for UGT2B4 (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-715843492
    Ethyl glucuronide 17685-04-016139098
    Hydroxycotinine(3R-trans)-3-hydroxy-1-methyl-5-(3-pyridinyl)-2-Pyrrolidinone (see all 5)34834-67-815470160
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-315843492
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----

    3 DrugBank Compounds for UGT2B4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FlurbiprofenFLP (see all 5)5104-49-4enzymesubstrate19515014
    IbuprofenIbuprophen (see all 3)15687-27-1enzymesubstrate19515014
    Morphine(-)-Heroin hydrochloride (see all 12)57-27-2enzymesubstrate20071451

    10/21 Novoseek chemical compound relationships for UGT2B4 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    digitoxigenin monodigitoxoside 91.5 2 8097706 (1), 2116803 (1)
    17-epiestriol 88.1 1 17263731 (1)
    4-hydroxyestrone 87.6 1 17263731 (1)
    udp glucuronic acid 87.6 4 1804651 (2), 8244999 (1), 1909117 (1)
    1-naphthol 80.4 5 1909117 (2), 2116803 (1), 1804651 (1), 10895755 (1)
    p-nitrophenol 66.1 4 1680659 (1), 2116769 (1)
    glucuronide 62.7 1 12806625 (1)
    carvedilol 54.1 4 14744946 (3), 16849011 (1)
    codeine 53.8 2 12920168 (2)
    17beta-hydroxysteroid 49.5 2 2116769 (1)

    Search CenterWatch for drugs/clinical trials and news about UGT2B4 / UD2B4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGT2B4 gene: 
    NM_021139.2  

    Unigene Cluster for UGT2B4:

    UDP glucuronosyltransferase 2 family, polypeptide B4
    Hs.285887  [show with all ESTs]
    Unigene Representative Sequence: BC026264
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512583 ENST00000305107(uc003hek.4 uc003hel.4) ENST00000506580
    ENST00000502655 ENST00000503836 ENST00000510114 ENST00000381096(uc011cap.2)


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    Additional cDNA sequence: 

    AF064200.1 AF081793.1 AJ005162.1 AK292748.1 AK300084.1 AY529122.1 BC026264.1 Y00317.1 

    4 DOTS entries:

    DT.100045797  DT.101980877  DT.100848422  DT.91741809 

    24 AceView cDNA sequences:

    AV682470 CB154140 AJ005162 AW275488 CB153390 BX494989 BX494777 AV681832 
    BG616908 BX447927 AI056512 CB116631 CB157502 BX100069 AI761968 BV183052 
    AF081793 BG564697 BG564164 AI032836 AF202345 CB154113 AW772540 AV699886 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT2B4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGATTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See UGT2B4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT2B4

    SOURCE GeneReport for Unigene cluster: Hs.285887
        SABiosciences Expression via Pathway-Focused PCR Arrays including UGT2B4: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UGT2B4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT2B4 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves F1NMB3_CHICK6
    Uncharacterized protein
    58(a)
    1 → many
    4(53288491-53295396)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    57(a)
    56(a)
    many ↔ many
    many ↔ many
    6(58564243-58578541)
    6(58629882-58649612)
    zebrafish
    (Danio rerio)
    Actinopterygii BX571679.16
    FP236810.46
    (see all 15)
    --
    64(a)
    53(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    5(9986135-9988976)
    5(9898582-9908402)


    ENSEMBL Gene Tree for UGT2B4 (if available)
    TreeFam Gene Tree for UGT2B4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT2B4 gene
    UGT2A22  UGT1A82  UGT1A72  UGT3A12  UGT2B72  UGT2B112  UGT1A32  UGT1A12  
    UGT1A52  UGT3A22  UGT2B102  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B172  
    UGT2A32  UGT2B282  UGT1A92  UGT1A42  
    18/30 SIMAP similar genes for UGT2B4 using alignment to 5 protein entries:     UD2B4_HUMAN (see all proteins) (see all similar genes):
    UGT2B7    UGT2B11    UGT2B28    UGT2B17    UGT2B15    UGT2B10
    UGT2A3    UGT1A3S    UGT1A9S    UGT2A1    UGT1A8S    UGT1A6
    UGT1A6S    BILIQTL1    UGT1A4S    UGT1A1    UGT1A10    UGT1A5

    UGT2B4 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for UGT2B4 (see all 7)
    PGOHUM00000245559 PGOHUM00000245564 PGOHUM00000259899 PGOHUM00000245580 PGOHUM00000259939


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for UGT2B4
         1 CNV: 3499
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT2B4
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT2B4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UGT2B4 for disorders           About GeneDecksing

    OMIM gene information: 600067    OMIM disorders: --

    15 diseases for UGT2B4:    About MalaCards
    familial adenomatous polyposis    gilbert syndrome    hearing loss    hepatoblastoma
    cholelithiasis    liver disease    polyposis    duodenitis
    prostate carcinoma    breast cancer    cholesterol    prostatitis
    carcinoma    pancreatitis    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for UGT2B4:
    Cholelithiasis     Gilbert syndrome

    2 Novoseek disease relationships for UGT2B4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatoblastoma 44 2 12806625 (1), 12810707 (1)
    liver diseases 14.5 1 8244999 (1)

    Genetic Association Database (GAD): UGT2B4
    Human Genome Epidemiology (HuGE) Navigator: UGT2B4 (14 documents)

    Export disorders for UGT2B4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT2B4 gene, integrated from 9 sources (see all 81):
    (articles sorted by number of sources associating them with UGT2B4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA. (PubMed id 3109396)1, 2, 3 Jackson M.R....Burchell B. (1987)
    2. Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (PubMed id 15319348)1, 4, 9 Saeki M....Sawada J. (2004)
    3. Characterization and substrate specificity of UGT2B4 (E458): a UDP- glucuronosyltransferase encoded by a polymorphic gene. (PubMed id 10376768)1, 2, 9 Levesque E.... Belanger A. (1999)
    4. Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13. (PubMed id 7835904)1, 3, 9 Monaghan G....Burchell B. (1994)
    5. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PubMed id 15318931)1, 4, 9 Sparks R....McTiernan A. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. (PubMed id 8333863)1, 2 Jin C.-J.... McKenzie P.I. (1993)
    8. Extensive splicing of transcripts encoding the bile a cid-conjugating enzyme UGT2B4 modulates glucuronidation. (PubMed id 20139797)1, 9 LAcvesque E....Guillemette C. (2010)
    9. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. (PubMed id 12806625)1, 9 Barbier O....Staels B. (2003)
    10. Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. (PubMed id 12810707)1, 9 Barbier O....Staels B. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7363 HGNC: 12553 AceView: UGT2B4 Ensembl:ENSG00000156096 euGenes: HUgn7363
    ECgene: UGT2B4 Kegg: 7363 H-InvDB: UGT2B4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT2B4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ugt2b4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGT2B4 gene:
    Search GeneIP for patents involving UGT2B4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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