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Aliases for UGT2B4 Gene

Aliases for UGT2B4 Gene

  • UDP Glucuronosyltransferase Family 2 Member B4 2 3 5
  • Hyodeoxycholic Acid-Specific UDPGT 3 4
  • EC 2.4.1.17 4 61
  • UDPGT 2B4 3 4
  • UDPGTh-1 3 4
  • UGT2B11 3 4
  • HLUG25 3 4
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B4 3
  • UDP Glycosyltransferase 2 Family, Polypeptide B4 2
  • UDP-Glucuronyltransferase, Family 2, Beta-4 3
  • UDP-Glucuronosyltransferase 2B4 3
  • Hyodeoxycholic Acid 3
  • UDPGT2B4 3
  • UDPGTH1 3

External Ids for UGT2B4 Gene

Previous GeneCards Identifiers for UGT2B4 Gene

  • GC04P070172
  • GC04M070394
  • GC04M070595
  • GC04M070661
  • GC04M070186
  • GC04M070526
  • GC04M070345
  • GC04M066144

Summaries for UGT2B4 Gene

GeneCards Summary for UGT2B4 Gene

UGT2B4 (UDP Glucuronosyltransferase Family 2 Member B4) is a Protein Coding gene. Among its related pathways are Porphyrin and chlorophyll metabolism and Farnesoid X Receptor Pathway. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B7.

UniProtKB/Swiss-Prot for UGT2B4 Gene

  • UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Gene Wiki entry for UGT2B4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B4 Gene

Genomics for UGT2B4 Gene

Regulatory Elements for UGT2B4 Gene

Enhancers for UGT2B4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G069544 0.7 ENCODE 42.3 -20.1 -20148 2.9 TFAP4 FOXA2 TAF1 MAX RAD21 YY1 HNF4G NFE2 MAFK FOXA3 UGT2B4 LOC100422024
GH04G069496 0.5 ENCODE 47 +28.6 28617 1.5 JUND GATAD2B DPF2 RELB UGT2B4 UGT2A3P7 ENSG00000249686
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UGT2B4 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2B4 Gene

Chromosome:
4
Start:
69,480,165 bp from pter
End:
69,526,014 bp from pter
Size:
45,850 bases
Orientation:
Minus strand

Genomic View for UGT2B4 Gene

Genes around UGT2B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B4 Gene

Proteins for UGT2B4 Gene

  • Protein details for UGT2B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06133-UD2B4_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B4
    Protein Accession:
    P06133
    Secondary Accessions:
    • A6NCP7
    • B4DT75
    • G5E9X8
    • O60731
    • O60867
    • O75614
    • P36538
    • Q1HBF9
    • Q6QQX7

    Protein attributes for UGT2B4 Gene

    Size:
    528 amino acids
    Molecular mass:
    60513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2B4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2B4 Gene

Selected DME Specific Peptides for UGT2B4 Gene

P06133:
  • AFITHGG
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • FVQSSGE
  • AAHDLTW
  • KPLDRAVFWIE
  • KLQESRFD
  • SHWMNIKTILDEL
  • YEAIYHG
  • RGHEVTVL
  • FVGGLHC
  • KKWDQFYSEVLGRPTTL
  • PPSYVPV
  • WIPQNDLLG
  • FLLACVA
  • IPQKVLW
  • DQPDNIAHMK
  • THGGANG
  • DLLNALK
  • GHPKTRAFITH
  • VVFSLGSMV
  • LSRIHHDQP
  • VMRHKGA
  • CGKVLVW
  • QYHSLDV
  • TMSSTDL
  • NALKTVINDP
  • NTRLYKW
  • ERVKNMIY

Post-translational modifications for UGT2B4 Gene

  • Glycosylation at Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B4 Gene

Domains & Families for UGT2B4 Gene

Gene Families for UGT2B4 Gene

Protein Domains for UGT2B4 Gene

Graphical View of Domain Structure for InterPro Entry

P06133

UniProtKB/Swiss-Prot:

UD2B4_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B4: view

Function for UGT2B4 Gene

Molecular function for UGT2B4 Gene

GENATLAS Biochemistry:
UDP glucuronosyltransferase 2,liver,bile acid conjugating
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Enzyme Numbers (IUBMB) for UGT2B4 Gene

Gene Ontology (GO) - Molecular Function for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IDA 18052087
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B4: view
genes like me logo Genes that share phenotypes with UGT2B4: view

Animal Model Products

miRNA for UGT2B4 Gene

miRTarBase miRNAs that target UGT2B4

Inhibitory RNA Products

Clone Products

Cell Line Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B4 Gene

Localization for UGT2B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B4 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2B4 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
peroxisome 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA,IEA --
genes like me logo Genes that share ontologies with UGT2B4: view

Pathways & Interactions for UGT2B4 Gene

genes like me logo Genes that share pathways with UGT2B4: view

Gene Ontology (GO) - Biological Process for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006711 estrogen catabolic process IDA 8333863
GO:0006805 xenobiotic metabolic process IDA 8333863
GO:0008152 metabolic process IEA,IDA 8333863
GO:0052695 cellular glucuronidation IDA 20056724
genes like me logo Genes that share ontologies with UGT2B4: view

No data available for SIGNOR curated interactions for UGT2B4 Gene

Drugs & Compounds for UGT2B4 Gene

(39) Drugs for UGT2B4 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist, Enzyme, substrate 77
Morphine Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate 1007
Flurbiprofen Approved, Investigational Pharma Channel blocker, Enzyme, substrate 49
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 563
Canagliflozin Approved Pharma Inhibition, Inhibitor, Enzyme, substrate SGLT2 inhibitor,potent and selective 109

(142) Additional Compounds for UGT2B4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
(3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronate
  • (3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-beta-delta-Glucopyranosiduronate
  • Taurolithocholic acid 3-glucuronide
99794-82-8
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
(3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid
  • Glycocholic acid 3-glucuronide
99794-78-2
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
genes like me logo Genes that share compounds with UGT2B4: view

Transcripts for UGT2B4 Gene

Unigene Clusters for UGT2B4 Gene

UDP glucuronosyltransferase 2 family, polypeptide B4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B4 Gene

No ASD Table

Relevant External Links for UGT2B4 Gene

GeneLoc Exon Structure for
UGT2B4
ECgene alternative splicing isoforms for
UGT2B4

Expression for UGT2B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGT2B4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B4 Gene

This gene is overexpressed in Liver (x50.5).

Protein differential expression in normal tissues from HIPED for UGT2B4 Gene

This gene is overexpressed in Liver (39.2) and Gallbladder (27.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGT2B4 Gene



Protein tissue co-expression partners for UGT2B4 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT2B4 Gene:

UGT2B4

SOURCE GeneReport for Unigene cluster for UGT2B4 Gene:

Hs.285887

Evidence on tissue expression from TISSUES for UGT2B4 Gene

  • Liver(4.8)
genes like me logo Genes that share expression patterns with UGT2B4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2B4 Gene

Orthologs for UGT2B4 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B4 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 82 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 75 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b7 34
  • 72.41 (n)
mouse
(Mus musculus)
Mammalia Ugt2b1 35
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007374 34
  • 44.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ugt86Dg 36
  • 35 (a)
CG6475 36
  • 33 (a)
BEST:GH09393 36
  • 31 (a)
Ugt35b 36
  • 31 (a)
CG15661 36
  • 30 (a)
Ugt35a 36
  • 30 (a)
Ugt86Dd 36
  • 30 (a)
Ugt86De 36
  • 28 (a)
CG10170 36
  • 25 (a)
Ugt86Dh 36
  • 25 (a)
CG10168 36
  • 23 (a)
worm
(Caenorhabditis elegans)
Secernentea F39G3.1 36
  • 30 (a)
M88.1 36
  • 30 (a)
C44H9.1 36
  • 26 (a)
Y37E11AR.5 36
  • 26 (a)
F56B3.7 36
  • 25 (a)
T03D3.1 36
  • 24 (a)
Species where no ortholog for UGT2B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B4 Gene

ENSEMBL:
Gene Tree for UGT2B4 (if available)
TreeFam:
Gene Tree for UGT2B4 (if available)

Paralogs for UGT2B4 Gene

Variants for UGT2B4 Gene

Sequence variations from dbSNP and Humsavar for UGT2B4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000049786 -- 69,513,347(+) TCCTT(C/T)CTTTA intron-variant
rs1000141981 -- 69,510,655(+) ATAAC(C/T)GATTT intron-variant
rs1000185556 -- 69,501,964(+) GTTAC(C/G)TGGGG intron-variant
rs1000187125 -- 69,513,669(+) GGCAA(A/C/T)ATGGC intron-variant
rs1000348008 -- 69,518,726(+) ACATC(C/G)ATTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B4 Gene

Variant ID Type Subtype PubMed ID
dgv1498e212 CNV loss 25503493
dgv5317n100 CNV gain 25217958
esv2671739 CNV deletion 23128226
esv2727783 CNV deletion 23290073
esv2759258 CNV gain+loss 17122850
esv3600908 CNV gain 21293372
esv3600909 CNV gain 21293372
esv3600913 CNV loss 21293372
esv3893958 CNV gain 25118596
nsv461548 CNV gain 19166990
nsv470045 CNV gain 18288195
nsv510892 OTHER complex 20534489
nsv594611 CNV gain 21841781
nsv967759 CNV duplication 23825009
nsv967760 CNV duplication 23825009

Variation tolerance for UGT2B4 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.13; 75.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2B4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B4 Gene

Disorders for UGT2B4 Gene

Relevant External Links for UGT2B4

Genetic Association Database (GAD)
UGT2B4
Human Genome Epidemiology (HuGE) Navigator
UGT2B4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2B4

No disorders were found for UGT2B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2B4 Gene

Publications for UGT2B4 Gene

  1. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PMID: 18161889) Berkhout M. … Peters W.H. (Br J Surg 2008) 3 22 46 64
  2. Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol. (PMID: 16849011) Takekuma Y. … Sugawara M. (J Pharm Pharm Sci 2006) 3 22 46 64
  3. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PMID: 15318931) Sparks R. … McTiernan A. (Breast Cancer Res. 2004) 3 22 46 64
  4. Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (PMID: 15319348) Saeki M. … Sawada J. (Drug Metab. Dispos. 2004) 3 22 46 64
  5. Characterization and substrate specificity of UGT2B4 (E458): a UDP- glucuronosyltransferase encoded by a polymorphic gene. (PMID: 10376768) Levesque E. … Belanger A. (Pharmacogenetics 1999) 3 4 22 64

Products for UGT2B4 Gene

Sources for UGT2B4 Gene

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