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Aliases for UGT2B4 Gene

Aliases for UGT2B4 Gene

  • UDP Glucuronosyltransferase 2 Family, Polypeptide B4 2 3
  • UGT2B11 3 4 6
  • Hyodeoxycholic Acid-Specific UDPGT 3 4
  • EC 2.4.1.17 4 64
  • UDPGT 2B4 3 4
  • UDPGTh-1 3 4
  • HLUG25 3 4
  • UDP Glycosyltransferase 2 Family, Polypeptide B4 2
  • UDP-Glucuronyltransferase, Family 2, Beta-4 3
  • UDP-Glucuronosyltransferase 2B4 3
  • Hyodeoxycholic Acid 3
  • UDPGT2B4 3
  • UDPGTH1 3

External Ids for UGT2B4 Gene

Summaries for UGT2B4 Gene

GeneCards Summary for UGT2B4 Gene

UGT2B4 (UDP Glucuronosyltransferase 2 Family, Polypeptide B4) is a Protein Coding gene. Diseases associated with UGT2B4 include gilbert syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include glucuronosyltransferase activity and retinoic acid binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2B4 Gene

  • UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

Gene Wiki entry for UGT2B4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B4 Gene

Genomics for UGT2B4 Gene

Genomic Location for UGT2B4 Gene

Start:
69,480,165 bp from pter
End:
69,526,014 bp from pter
Size:
45,850 bases
Orientation:
Minus strand

Genomic View for UGT2B4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT2B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B4 Gene

Regulatory Elements for UGT2B4 Gene

Proteins for UGT2B4 Gene

  • Protein details for UGT2B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06133-UD2B4_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B4
    Protein Accession:
    P06133
    Secondary Accessions:
    • A6NCP7
    • B4DT75
    • G5E9X8
    • O60731
    • O60867
    • O75614
    • P36538
    • Q1HBF9
    • Q6QQX7

    Protein attributes for UGT2B4 Gene

    Size:
    528 amino acids
    Molecular mass:
    60513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2B4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2B4 Gene

Proteomics data for UGT2B4 Gene at MOPED

Post-translational modifications for UGT2B4 Gene

Other Protein References for UGT2B4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UGT2B4 Gene

Gene Families for UGT2B4 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT2B4 Gene

UniProtKB/Swiss-Prot:

UD2B4_HUMAN
Family:
  • Belongs to the UDP-glycosyltransferase family.:
    • P06133
genes like me logo Genes that share domains with UGT2B4: view

Function for UGT2B4 Gene

Molecular function for UGT2B4 Gene

GENATLAS Biochemistry: UDP glucuronosyltransferase 2,liver,bile acid conjugating
UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
UniProtKB/Swiss-Prot Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

Enzyme Numbers (IUBMB) for UGT2B4 Gene

Gene Ontology (GO) - Molecular Function for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IDA 18052087
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT2B4: view

miRNA for UGT2B4 Gene

miRTarBase miRNAs that target UGT2B4

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UGT2B4 Gene

Localization for UGT2B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B4 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B4 Gene COMPARTMENTS Subcellular localization image for UGT2B4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
peroxisome 2
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2B4: view

Pathways for UGT2B4 Gene

genes like me logo Genes that share pathways with UGT2B4: view

Pathways by source for UGT2B4 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for UGT2B4 Gene
2 BioSystems pathways for UGT2B4 Gene

Interacting Proteins for UGT2B4 Gene

Gene Ontology (GO) - Biological Process for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006711 estrogen catabolic process IDA 8333863
GO:0006805 xenobiotic metabolic process IDA 8333863
GO:0008152 metabolic process IDA 8333863
GO:0009813 flavonoid biosynthetic process IBA --
genes like me logo Genes that share ontologies with UGT2B4: view

Compounds for UGT2B4 Gene

(86) HMDB Compounds for UGT2B4 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available

(5) Drugbank Compounds for UGT2B4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Canagliflozin
842133-18-0 enzyme substrate
Codeine
  • Codeine anhydrous
76-57-3 enzyme substrate
Flurbiprofen
  • FLP
5104-49-4 enzyme substrate
Ibuprofen
  • Ibuprophen
15687-27-1 enzyme substrate
Morphine
  • (-)-Heroin hydrochloride
57-27-2 enzyme substrate

(21) Novoseek inferred chemical compound relationships for UGT2B4 Gene

Compound -log(P) Hits PubMed IDs
digitoxigenin monodigitoxoside 91.5 2
17-epiestriol 88.1 1
4-hydroxyestrone 87.6 1
udp glucuronic acid 87.6 4
1-naphthol 80.4 5

(2) PharmGKB related drug/compound annotations for UGT2B4 Gene

Drug/compound Annotation
clobazam
codeine
genes like me logo Genes that share compounds with UGT2B4: view

Transcripts for UGT2B4 Gene

Unigene Clusters for UGT2B4 Gene

UDP glucuronosyltransferase 2 family, polypeptide B4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B4 Gene

No ASD Table

Relevant External Links for UGT2B4 Gene

GeneLoc Exon Structure for
UGT2B4
ECgene alternative splicing isoforms for
UGT2B4

Expression for UGT2B4 Gene

mRNA expression in normal human tissues for UGT2B4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B4 Gene

This gene is overexpressed in Liver (50.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2B4 Gene

SOURCE GeneReport for Unigene cluster for UGT2B4 Gene Hs.285887

genes like me logo Genes that share expressions with UGT2B4: view

Orthologs for UGT2B4 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B4 36
  • 99.31 (n)
  • 98.48 (a)
UGT2B4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt2b1 37
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b7 36
  • 72.41 (n)
  • 64.2 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007374 36
  • 44.59 (n)
  • 32.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta BEST:GH09393 38
  • 31 (a)
CG10168 38
  • 23 (a)
Ugt86De 38
  • 28 (a)
CG10170 38
  • 25 (a)
Ugt86Dd 38
  • 30 (a)
Ugt35b 38
  • 31 (a)
CG15661 38
  • 30 (a)
Ugt86Dh 38
  • 25 (a)
Ugt35a 38
  • 30 (a)
CG6475 38
  • 33 (a)
Ugt86Dg 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea F56B3.7 38
  • 25 (a)
Y37E11AR.5 38
  • 26 (a)
T03D3.1 38
  • 24 (a)
C44H9.1 38
  • 26 (a)
F39G3.1 38
  • 30 (a)
M88.1 38
  • 30 (a)
Species with no ortholog for UGT2B4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B4 Gene

ENSEMBL:
Gene Tree for UGT2B4 (if available)
TreeFam:
Gene Tree for UGT2B4 (if available)

Paralogs for UGT2B4 Gene

genes like me logo Genes that share paralogs with UGT2B4: view

Variants for UGT2B4 Gene

Sequence variations from dbSNP and Humsavar for UGT2B4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs161647 -- 69,504,576(-) aggtt(C/T)cattc intron-variant
rs172861 -- 69,493,345(+) TGTAA(A/G)GTGTG intron-variant
rs188967 -- 69,517,690(+) ACTGT(A/C)CCAAA intron-variant
rs324316 -- 69,511,606(-) ataaa(A/G)aacag intron-variant
rs324317 -- 69,517,261(-) ATTTC(A/C/T)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B4 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
dgv1634e1 CNV Complex 17122850
dgv1636e1 CNV Complex 17122850
nsv461548 CNV Gain 19166990
dgv5623n71 CNV Gain 21882294
nsv470045 CNV Gain 18288195

Relevant External Links for UGT2B4 Gene

HapMap Linkage Disequilibrium report
UGT2B4

Disorders for UGT2B4 Gene

(1) MalaCards Diseases for UGT2B4 Gene

Search for UGT2B4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for UGT2B4 Gene

(2) Novoseek inferred disease relationships for UGT2B4 Gene

Disease -log(P) Hits PubMed IDs
hepatoblastoma 44 2
liver diseases 14.5 1

Relevant External Links for UGT2B4

Genetic Association Database (GAD)
UGT2B4
Human Genome Epidemiology (HuGE) Navigator
UGT2B4
genes like me logo Genes that share disorders with UGT2B4: view

No data available for UniProtKB/Swiss-Prot for UGT2B4 Gene

Publications for UGT2B4 Gene

  1. Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13. (PMID: 7835904) Monaghan G. … Burchell B. (Genomics 1994) 2 3 23
  2. Characterization and substrate specificity of UGT2B4 (E458): a UDP- glucuronosyltransferase encoded by a polymorphic gene. (PMID: 10376768) Levesque E. … Belanger A. (Pharmacogenetics 1999) 3 4 23
  3. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PMID: 15318931) Sparks R. … McTiernan A. (Breast Cancer Res. 2004) 3 23 49
  4. Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (PMID: 15319348) Saeki M. … Sawada J. (Drug Metab. Dispos. 2004) 3 23 49
  5. Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol. (PMID: 16849011) Takekuma Y. … Sugawara M. (J Pharm Pharm Sci 2006) 3 23 49

Products for UGT2B4 Gene

Sources for UGT2B4 Gene

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