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UGT2B4 Gene

protein-coding   GIFtS: 64
GCID: GC04M070345

UDP Glucuronosyltransferase 2 Family, Polypeptide B4

(Previous names: UDP glycosyltransferase 2 family, polypeptide B4)
  See UGT2B4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B41 2     UDP Glycosyltransferase 2 Family, Polypeptide B41
UGT2B112 3 5     UDPGT2B42
Hyodeoxycholic Acid-Specific UDPGT2 3     UDPGTH12
HLUG252 3     Hyodeoxycholic Acid2
UDPGTh-12 3     UDP Glucuronosyltransferase 2B42
UDPGT 2B42 3     UDP-Glucuronosyltransferase 2B42
EC 2.4.1.173 8     UDP-Glucuronyltransferase, Family 2, Beta-42

External Ids:    HGNC: 125531   Entrez Gene: 73632   Ensembl: ENSG000001560967   OMIM: 6000675   UniProtKB: P061333   
ORGUL members:         

Export aliases for UGT2B4 gene to outside databases

Previous GC identifers: GC04P070172 GC04M070394 GC04M070595 GC04M070661 GC04M070186 GC04M070526 GC04M066144


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UGT2B4 Gene:
UGT2B4 (UDP glucuronosyltransferase 2 family, polypeptide B4) is a protein-coding gene. Diseases associated with UGT2B4 include gilbert syndrome. GO annotations related to this gene include retinoic acid binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD2B4_HUMAN, P06133
Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol,
4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol,
2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic
acid

Gene Wiki entry for UGT2B4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UGT2B4 gene promoter:
         LUN-1   HNF-4alpha1   Gfi-1   PPAR-alpha   PPAR-gamma1   FOXO1a   PPAR-gamma2   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UGT2B4 promoter sequence
   Search Chromatin IP Primers for UGT2B4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT2B4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13

UGT2B4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M070345:  view genomic region     (about GC identifiers)

Start:
70,345,883 bp from pter      End:
70,391,732 bp from pter
Size:
45,850 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UD2B4_HUMAN, P06133 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2B4 precursor  
Size: 528 amino acids; 60513 Da
Caution: PubMed:8333863 thought that this was a new form (UGT2B11). The name UGT2B11 has now been reused for
another human enzyme
Secondary accessions: O60731 O60867 O75614 P36538 Q1HBF9

Explore the universe of human proteins at neXtProt for UGT2B4: NX_P06133

Explore proteomics data for UGT2B4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn315
  • Selected DME Specific Peptides for UGT2B4 (P06133) (see all 30)
     DLLNALK  AFITHGG  CGKVLVW  LLGHPKT 


    See UGT2B4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066962.2  
    ENSEMBL proteins: 
     ENSP00000421290   ENSP00000305221   ENSP00000421113   ENSP00000370486  
    Reactome Protein details: P06133

    UGT2B4 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UGT2B4

     
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    antibodies-online proteins for UGT2B4 (2 products) 

     
    antibodies-online peptides for UGT2B4

    UGT2B4 Antibody Products:

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    antibodies-online antibodies for UGT2B4 (30 products) 

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    Cloud-Clone Corp. CLIAs for UGT2B4
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    antibodies-online kits for UGT2B4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P06133

    ProtoNet protein and cluster: P06133

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD2B4_HUMAN, P06133
    Similarity: Belongs to the UDP-glycosyltransferase family


    Find genes that share domains with UGT2B4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD2B4_HUMAN, P06133
    Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol,
    4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol,
    2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic
    acid
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Genatlas biochemistry entry for UGT2B4:
    UDP glucuronosyltransferase 2,liver,bile acid conjugating

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972NOT retinoic acid binding IDA--
    GO:0015020glucuronosyltransferase activity IDA18052087
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    Find genes that share ontologies with UGT2B4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UGT2B4

    miRNA
    Products:
        
    miRTarBase miRNAs that target UGT2B4:
    hsa-mir-335-5p (MIRT017601)

    Block miRNA regulation of human, mouse, rat UGT2B4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UGT2B4
    SwitchGear 3'UTR luciferase reporter plasmidUGT2B4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UGT2B4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UGT2B4

    Clone
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    GenScript: all cDNA clones in your preferred vector: UGT2B4 (NM_021139)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT2B4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2B4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UD2B4_HUMAN, P06133: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum
    membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    peroxisome2
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with UGT2B4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGT2B4 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Glucuronidation0.00
    Phase II conjugation0.56
    Benzodiazepine Pathway, Pharmacokinetics0.00
    metapathway biotransformation0.42
    2Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    5Metabolism of porphyrins
    Porphyrin and chlorophyll metabolism0.56


    Find genes that share SuperPaths with UGT2B4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UGT2B4
        Glucuronidation
    metapathway biotransformation

    1 Reactome Pathway for UGT2B4
        Glucuronidation

    1 PharmGKB Pathway for UGT2B4
        Benzodiazepine Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for UGT2B4) (see all 12):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UGT2B4: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UGT2B4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT2B4 (ENSP000003052214) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    AKR1D1ENSP000002423754STRING: ENSP00000242375
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    CES2ENSP000003178424STRING: ENSP00000317842
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006711estrogen catabolic process IDA8333863
    GO:0006805xenobiotic metabolic process IDA8333863
    GO:0008152metabolic process IDA8333863
    GO:0030259lipid glycosylation ----

    Find genes that share ontologies with UGT2B4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT2B4 (UD2B4)

    Selected HMDB Compounds for UGT2B4 (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-715843492
    Ethyl glucuronide 17685-04-016139098
    Hydroxycotinine(3R-trans)-3-hydroxy-1-methyl-5-(3-pyridinyl)-2-Pyrrolidinone (see all 5)34834-67-815470160
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-315843492
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----

    5 DrugBank Compounds for UGT2B4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FlurbiprofenFLP (see all 5)5104-49-4enzymesubstrate19515014
    IbuprofenIbuprophen (see all 3)15687-27-1enzymesubstrate19515014
    Morphine(-)-Heroin hydrochloride (see all 12)57-27-2enzymesubstrate20071451
    Canagliflozin-- 842133-18-0enzymesubstrate--
    CodeineCodeine anhydrous (see all 6)76-57-3enzymesubstrate--

    Selected Novoseek inferred chemical compound relationships for UGT2B4 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    digitoxigenin monodigitoxoside 91.5 2 8097706 (1), 2116803 (1)
    17-epiestriol 88.1 1 17263731 (1)
    4-hydroxyestrone 87.6 1 17263731 (1)
    udp glucuronic acid 87.6 4 1804651 (2), 8244999 (1), 1909117 (1)
    1-naphthol 80.4 5 1909117 (2), 2116803 (1), 1804651 (1), 10895755 (1)
    p-nitrophenol 66.1 4 1680659 (1), 2116769 (1)
    glucuronide 62.7 1 12806625 (1)
    carvedilol 54.1 4 14744946 (3), 16849011 (1)
    codeine 53.8 2 12920168 (2)
    17beta-hydroxysteroid 49.5 2 2116769 (1)

    2 PharmGKB related drug/compound annotations for UGT2B4 gene    About this table
    Drug/compound PharmGKB Annotation
    clobazam
    codeine



    Find genes that share compounds with UGT2B4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UGT2B4 gene: 
    NM_021139.2  

    Unigene Cluster for UGT2B4:

    UDP glucuronosyltransferase 2 family, polypeptide B4
    Hs.285887  [show with all ESTs]
    Unigene Representative Sequence: BC026264
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512583 ENST00000305107(uc003hek.4 uc003hel.4) ENST00000506580
    ENST00000502655 ENST00000503836 ENST00000510114 ENST00000381096(uc011cap.2)

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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGT2B4
      QuantiTect SYBR Green Assays in human, mouse, rat UGT2B4
      QuantiFast Probe-based Assays in human, mouse, rat UGT2B4

    Additional mRNA sequence: 

    AF064200.1 AF081793.1 AJ005162.1 AK292748.1 AK300084.1 AY529122.1 BC026264.1 Y00317.1 

    4 DOTS entries:

    DT.100045797  DT.101980877  DT.100848422  DT.91741809 

    24 AceView cDNA sequences:

    AV682470 AW275488 BX494989 CB153390 BX494777 AJ005162 CB154140 AI761968 
    CB116631 AF081793 BV183052 BX100069 AI056512 BG616908 CB157502 AV681832 
    BX447927 BG564697 BG564164 AI032836 AF202345 CB154113 AW772540 AV699886 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UGT2B4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGATTGTG
    UGT2B4 Expression
    About this image


    UGT2B4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    UGT2B4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT2B4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.285887
        Pathway & Disease-focused RT2 Profiler PCR Arrays including UGT2B4: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat UGT2B4
    QuantiFast Probe-based Assays in human, mouse, rat UGT2B4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2B4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UGT2B4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0073741 AgaP_AGAP007374 44.59(n)
    32.49(a)
      1269809  XM_308459.4  XP_308459.4 
            Species with no ortholog for UGT2B4

    ENSEMBL Gene Tree for UGT2B4 (if available)
    TreeFam Gene Tree for UGT2B4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGT2B4 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  
    UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    Selected SIMAP similar genes for UGT2B4 using alignment to 5 protein entries:     UD2B4_HUMAN (see all proteins) (see all similar genes):
    UGT2B7    UGT2B11    UGT2B28    UGT2B17    UGT2B15    UGT2B10
    UGT2A3    UGT1A3S    UGT1A9S    UGT2A1    UGT2A2    UGT1A8S
    UGT1A6    UGT1A6S    BILIQTL1    UGT1A4S    UGT1A1    UGT1A10

    Find genes that share paralogs with UGT2B4           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for UGT2B4 (see all 7)
    PGOHUM00000245559 PGOHUM00000245564 PGOHUM00000259899 PGOHUM00000245580 PGOHUM00000259939


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UGT2B4 (see all 526)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs412982511,2
    C,F--70345393(-) ATGTCC/TTAATA 1 -- int111Minor allele frequency- T:0.47NS NA CSA WA EA 528
    rs1873507701,2
    --70345394(+) ATTAGA/GACATA 1 -- int10--------
    rs1922311751,2
    --70345507(+) AGTAAC/TGAGTG 1 -- int10--------
    rs27364451,2
    C,H--70345608(+) AAAGAA/GTAAAA 1 -- int14Minor allele frequency- G:0.00EA NS NA 284
    rs412982491,2
    C,F--70345620(-) ATATTC/TATCTT 1 -- int15Minor allele frequency- T:0.01NS 188
    rs27364461,2
    C,F,A,H--70345669(+) CAAACA/GCATTG 1 -- int128Minor allele frequency- G:0.26NS EA NA WA CSA 2541
    rs766392441,2
    C,F--70345834(+) TAAAAG/ACCAAG 1 -- int12Minor allele frequency- A:0.02NA EA 240
    rs752260161,2
    C--70345902(-) GAAGCA/TAATAA 1 -- ut311Minor allele frequency- T:0.00CSA 1
    rs11318781,2
    C,F,A,H--70345904(-) AGGAAA/GCTAAT 1 -- ut3129Minor allele frequency- G:0.26NS EA NA WA CSA 2895
    rs1907596001,2
    --70346054(+) AGTAAA/TTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UGT2B4 (70345883 - 70391732 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for UGT2B4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5623n71CNV Gain21882294
    nsv470045CNV Gain18288195
    nsv461548CNV Gain19166990
    dgv1634e1CNV Complex17122850
    dgv1636e1CNV Complex17122850
    dgv1628e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT2B4
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT2B4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600067    OMIM disorders: --

    1 disease for UGT2B4:    
    About MalaCards
    gilbert syndrome

    2 diseases from the University of Copenhagen DISEASES database for UGT2B4:
    Cholelithiasis     Gilbert syndrome

    Find genes that share disorders with UGT2B4           About GenesLikeMe

    2 Novoseek inferred disease relationships for UGT2B4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatoblastoma 44 2 12806625 (1), 12810707 (1)
    liver diseases 14.5 1 8244999 (1)

    Genetic Association Database (GAD): UGT2B4
    Human Genome Epidemiology (HuGE) Navigator: UGT2B4 (14 documents)

    Export disorders for UGT2B4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGT2B4 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with UGT2B4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA. (PubMed id 3109396)1, 2, 3 Jackson M.R....Burchell B. (Biochem. J. 1987)
    2. Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (PubMed id 15319348)1, 4, 9 Saeki M....Sawada J. (Drug Metab. Dispos. 2004)
    3. Characterization and substrate specificity of UGT2B4 (E458): a UDP- glucuronosyltransferase encoded by a polymorphic gene. (PubMed id 10376768)1, 2, 9 Levesque E.... Belanger A. (Pharmacogenetics 1999)
    4. Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol. (PubMed id 16849011)1, 4, 9 Takekuma Y....Sugawara M. (amp 2006)
    5. Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13. (PubMed id 7835904)1, 3, 9 Monaghan G....Burchell B. (Genomics 1994)
    6. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PubMed id 18161889)1, 4, 9 Berkhout M....Peters W.H. (Br J Surg 2008)
    7. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PubMed id 15318931)1, 4, 9 Sparks R....McTiernan A. (Breast Cancer Res. 2004)
    8. Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States. (PubMed id 20142249)1, 4 Yong M....Lampe J.W. (amp 2010)
    9. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    10. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PubMed id 20214802)1, 4 Li J....Hall P. (Breast Cancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7363 HGNC: 12553 AceView: UGT2B4 Ensembl:ENSG00000156096 euGenes: HUgn7363
    ECgene: UGT2B4 Kegg: 7363 H-InvDB: UGT2B4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UGT2B4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ugt2b4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UGT2B4 gene:
    Search GeneIP for patents involving UGT2B4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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