UGT2B28 Gene
protein-coding GIFtS: 53
GCID: GC04P070194
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UDP glucuronosyltransferase 2 family, polypeptide B28(Previous names: UDP glycosyltransferase 2 family, polypeptide B28 )
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Aliases for UGT2B28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| UDP Glucuronosyltransferase 2 Family, Polypeptide B281 2 | | UDP Glycosyltransferase 2 Family, Polypeptide B281 2 | | UDPGT 2B282 3 | | EC 2.4.1.173 8 | | UDP-Glucuronosyltransferase 2B282 |
Export aliases for UGT2B28 gene to outside databasesPrevious GC identifers: GC04M070372 GC04P070396 GC04P070461 GC04P070327 GC04P065944 |
Summaries for UGT2B28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for UGT2B28: This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzesthe transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates includingsteroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in themetabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While bothisoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. (provided by RefSeq,May 2011) UniProtKB/Swiss-Prot: UDB28_HUMAN, Q9BY64Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobioticsand endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active
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Genomic Views for UGT2B28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NT_022778.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UGT2B28 gene promoter: C/EBPbeta AML1a Nkx2-2 FOXD1 E47 FOXO1a Hand1 FOXO1 Other transcription factors
Search SABiosciences Chromatin IP Primers for UGT2B28
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2B28 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.2 Ensembl cytogenetic band: 4q13.2 HGNC cytogenetic band: 4q13.3UGT2B28 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P070194: view genomic region
(about GC identifiers)
Start:
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70,146,217 bp from pter |
End:
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70,160,768 bp from pter |
Size:
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14,552 bases |
Orientation:
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plus strand |
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Proteins for UGT2B28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: UDB28_HUMAN, Q9BY64 (See
protein sequence)Recommended Name: UDP-glucuronosyltransferase 2B28 precursor Size: 529 amino acids; 60906 Da
Subcellular location: Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-passmembrane protein
Sequence caution: Sequence=AAK31809.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: B5BUM0 Q9BY62 Q9BY63Alternative splicing: 2 isoforms: Q9BY64-1 Q9BY64-2 Explore the universe of human proteins at neXtProt for UGT2B28: NX_Q9BY64
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BY64 4/26 DME Specific Peptides for UGT2B28 (Q9BY64) (see all 26)
UGT2B28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001193933.1 NP_444267.1 ENSEMBL proteins: ENSP00000334276 ENSP00000427399 Reactome Protein details: Q9BY64 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
UGT2B28 for ontologies About GeneDecksing
UGT2B28 Antibody Products: Assay Products for UGT2B28: |
Protein
Domains / Families for UGT2B28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UGT2B28 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BY64ProtoNet protein and cluster: Q9BY64 1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase
UniProtKB/Swiss-Prot: UDB28_HUMAN, Q9BY64Similarity: Belongs to the UDP-glycosyltransferase family |
Function for UGT2B28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: UDB28_HUMAN, Q9BY64Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobioticsand endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be activeCatalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronosideEnzyme Number (IUBMB): EC 2.4.1.171 2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT2B28 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT2B28 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for UGT2B28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT2B28  |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015020 | glucuronosyltransferase activity |
IEA | -- |
UGT2B28 for ontologies About GeneDecksing
|
Pathways & Interactions for UGT2B28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Glucuronidation | | | 2 | Drug metabolism - cytochrome P450 | | | 3 | Biological oxidations | | | 4 | Metabolism | | | 5 | Pentose and glucuronate interconversions | |
Pathway sources See GeneCards unified pathways Show all pathways
1 EMD Millipore Pathway for UGT2B28
1 GeneGo (Thomson Reuters) Pathway for UGT2B28 2 BioSystems Pathways for UGT2B28 
4
Reactome Pathways for UGT2B28
5/11
Kegg Pathways (Kegg details for UGT2B28) (see all 11):
UGT2B28 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT2B28
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
UGT2B28 for ontologies About GeneDecksing
|
Drugs & Compounds for UGT2B28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for UGT2B28
10/85 HMDB Compounds for UGT2B28 (see all 85) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide) | (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5) | -- | -- | | 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid | Ibuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5) | 115075-59-7 | -- | | 1-Salicylate glucuronide | 1-salicylic acid glucuronide | -- | -- | | 11-Hydroxyprogesterone 11-glucuronide | 11-hydroxyprogesterone 11-glucuronoside (see all 5) | 77710-64-6 | -- | | 11-Oxo-androsterone glucuronide | 11-oxo-etiocholanolone glucuronide (see all 3) | -- | -- | | 11-beta-hydroxyandrosterone-3-glucuronide | 11-beta-hydroxyetiocholanolone-3-glucuronide | -- | -- | | 15-hydroxynorandrostene-3,17-dione glucuronide | 15-HNADG (see all 5) | 131749-23-0 | -- | | 16-alpha,17-beta-estriol 17-beta-D-glucuronide | estra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7) | 7219-89-8 | -- | | 17-alpha-estradiol-3-glucuronide | | -- | -- | | 17-beta-estradiol glucuronide | | -- | -- | Search CenterWatch for drugs/clinical trials and news about UGT2B28 / UDB28 
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Transcripts for UGT2B28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for UGT2B28 gene (2 alternative transcripts): NM_001207004.1 NM_053039.1 Unigene Cluster for UGT2B28: UDP glucuronosyltransferase 2 family, polypeptide B28 Hs.653154 [show with all ESTs]Unigene Representative Sequence: AF1772722 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335568(uc003hej.3) ENST00000511240(uc010ihr.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT2B28 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT2B28 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UGT2B28 (NM_053039) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UGT2B28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT2B28  |
Additional cDNA sequence: AB451456.1 AF177272.1 AF177273.1 3 DOTS entries: DT.121219029 DT.91760196 DT.95372476 24/35 AceView cDNA sequences (see all 35): CB164598 NM_001075 T57898 T46839 H69250 CD013994 CD013995 CB161428 BG189133 BV199400 BV199399 AV696157 BV199398 BG201991 AI688814 BV201798 BV172697 CB113377 BG212458 CD610478 AI032906 T57980 R00510 N78136 GeneLoc Exon Structure
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Expression for UGT2B28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UGT2B28 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATCAACCAGT
About this image See UGT2B28 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UGT2B28
SOURCE GeneReport for Unigene cluster: Hs.653154 UniProtKB/Swiss-Prot: UDB28_HUMAN, Q9BY64Tissue specificity: Expressed in the liver, breast and kidney SABiosciences Expression via Pathway-Focused PCR Array including UGT2B28: | Drug Metabolism: Phase II Enzymes in human mouse rat |
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT2B28 Browse OriGene validated miRNA SYBR primer pairs
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Orthologs for UGT2B28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for UGT2B28 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for UGT2B28 (if available) TreeFam Gene Tree for UGT2B28 (if available)  |
Paralogs for UGT2B28 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for UGT2B28 gene
- UGT2A22 UGT1A82 UGT1A72 UGT3A12 UGT2B72 UGT2B112 UGT1A32 UGT1A12
- UGT1A52 UGT3A22 UGT2B102 UGT1A102 UGT1A62 UGT82 UGT2B152 UGT2B42
- UGT2B172 UGT2A32 UGT1A92 UGT1A42
18/26 SIMAP similar genes for UGT2B28 using alignment to 1 protein entry: UDB28_HUMAN(see all similar genes):UGT2B11 UGT2B7 UGT2B4 UGT2B17 UGT2B15 UGT2B10 UGT2A3 UGT1A9S UGT2A1 UGT1A5 UGT1A8S BILIQTL1 UGT1A6 UGT1A8 UGT1A1 UGT1A4 UGT1A7 UGT1A10
UGT2B28 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for UGT2B28 PGOHUM00000250778 PGOHUM00000259942
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Genomic Variants for UGT2B28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 18 variations for UGT2B28 15/17 CNVs (see all 17): 68742 2528 1394 92185 1674 38069 32616 68743 38967 7449 0701 80355 3499 7450 2073 1 Inversion: 29481 Human Gene Mutation Database (HGMD): UGT2B28
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT2B28 |
|
Disorders
/ Diseases for UGT2B28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UGT2B28 for disorders About GeneDecksing
OMIM gene information: 606497
OMIM disorders: --
5 diseases for UGT2B28: About MalaCardskernicterus hearing loss prostate cancer cholesterol prostatitis Human Genome Epidemiology (HuGE) Navigator: UGT2B28 (2 documents) Export disorders for UGT2B28 gene to outside databases
|
Publications for UGT2B28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UGT2B28 gene integrated from 9 sources: (articles sorted by number of sources associating them with UGT2B28) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. (PubMed id 11300766)1, 2, 3, 9 Levesque E....Belanger A. (2001)
- Quantitative analysis of UGT2B28 mRNA expression by r eal-time RT-PCR and application to human tissue distribution study. (PubMed id 21679149)1 Ohno S. and Nakajin S. (2011)
- Genetic variation of genes involved in dihydrotestost erone metabolism and the risk of prostate cancer. (PubMed id 20056642)1 Setlur S.R....Demichelis F. (2010)
- Copy-number variations (CNVs) of the human sex steroi d metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism. (PubMed id 19572376)1 MAcnard V....LAcvesque E. (2009)
- Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1 Ross C.J....Hayden M.R. (2009)
- Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (2008)
- Differential localisation of UDP-glucuronosyltransferase in kidney during human embryonic and fetal development. (PubMed id 7755484)9 Hume R....Burchell B. (1995)
- In vitro studies in microsomes from rat and human liver, kidney, and intestine suggest that perfluorooctanoic acid is not a substrate for microsomal UDP-glucuronosyltransferases. (PubMed id 16051554)9 Kemper R.A. and Nabb D.L. (2005)
|
External Searches for UGT2B28 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UGT2B28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UGT2B28 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UGT2B28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for UGT2B28 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UGT2B28 gene: Search GeneIP for patents involving UGT2B28
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for UGT2B28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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