Aliases for UGT2B28 Gene
External Ids for UGT2B28 Gene
Previous GeneCards Identifiers for UGT2B28 Gene
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]
GeneCards Summary for UGT2B28 Gene
UGT2B28 (UDP Glucuronosyltransferase 2 Family, Polypeptide B28) is a Protein Coding gene. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.
UniProtKB/Swiss-Prot for UGT2B28 Gene
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.