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Aliases for UGT2B28 Gene

Aliases for UGT2B28 Gene

  • UDP Glucuronosyltransferase Family 2 Member B28 2 3
  • EC 2.4.1.17 4 63
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B28 5
  • UDP Glycosyltransferase 2 Family, Polypeptide B28 2
  • UDPGT 2B28 4

External Ids for UGT2B28 Gene

Previous GeneCards Identifiers for UGT2B28 Gene

  • GC04M070372
  • GC04P070194
  • GC04P070396
  • GC04P070461
  • GC04P070327
  • GC04P065944

Summaries for UGT2B28 Gene

Entrez Gene Summary for UGT2B28 Gene

  • This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]

GeneCards Summary for UGT2B28 Gene

UGT2B28 (UDP Glucuronosyltransferase Family 2 Member B28) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2B28 Gene

  • UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B28 Gene

Genomics for UGT2B28 Gene

Regulatory Elements for UGT2B28 Gene

Genomic Location for UGT2B28 Gene

Chromosome:
4
Start:
69,280,468 bp from pter
End:
69,423,402 bp from pter
Size:
142,935 bases
Orientation:
Plus strand

Genomic View for UGT2B28 Gene

Genes around UGT2B28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B28 Gene

Proteins for UGT2B28 Gene

  • Protein details for UGT2B28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY64-UDB28_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B28
    Protein Accession:
    Q9BY64
    Secondary Accessions:
    • B5BUM0
    • Q9BY62
    • Q9BY63

    Protein attributes for UGT2B28 Gene

    Size:
    529 amino acids
    Molecular mass:
    60906 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK31809.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for UGT2B28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2B28 Gene

Proteomics data for UGT2B28 Gene at MOPED

Post-translational modifications for UGT2B28 Gene

  • Glycosylation at Asn 315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B28 Gene

Domains & Families for UGT2B28 Gene

Gene Families for UGT2B28 Gene

Protein Domains for UGT2B28 Gene

Suggested Antigen Peptide Sequences for UGT2B28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY64

UniProtKB/Swiss-Prot:

UDB28_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B28: view

Function for UGT2B28 Gene

Molecular function for UGT2B28 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

Enzyme Numbers (IUBMB) for UGT2B28 Gene

Gene Ontology (GO) - Molecular Function for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B28: view
genes like me logo Genes that share phenotypes with UGT2B28: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B28 Gene

Localization for UGT2B28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B28 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B28 Gene COMPARTMENTS Subcellular localization image for UGT2B28 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
peroxisome 2
cytoskeleton 1
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT2B28: view

Pathways & Interactions for UGT2B28 Gene

genes like me logo Genes that share pathways with UGT2B28: view

Pathways by source for UGT2B28 Gene

Interacting Proteins for UGT2B28 Gene

Gene Ontology (GO) - Biological Process for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052696 flavonoid glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT2B28: view

No data available for SIGNOR curated interactions for UGT2B28 Gene

Drugs & Compounds for UGT2B28 Gene

(13) Drugs for UGT2B28 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 68
Estradiol Approved, Investigational Pharma Sex hormone 1094
Estriol Approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 19
Morphine Approved, Investigational Pharma Full agonist, Agonist 855

(84) Additional Compounds for UGT2B28 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT2B28: view

Transcripts for UGT2B28 Gene

mRNA/cDNA for UGT2B28 Gene

Unigene Clusters for UGT2B28 Gene

UDP glucuronosyltransferase 2 family, polypeptide B28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B28 Gene

No ASD Table

Relevant External Links for UGT2B28 Gene

GeneLoc Exon Structure for
UGT2B28
ECgene alternative splicing isoforms for
UGT2B28

Expression for UGT2B28 Gene

mRNA expression in normal human tissues for UGT2B28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B28 Gene

This gene is overexpressed in Bladder (x19.7), Liver (x11.1), Skin - Not Sun Exposed (Suprapubic) (x6.7), and Breast - Mammary Tissue (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2B28 Gene



SOURCE GeneReport for Unigene cluster for UGT2B28 Gene Hs.653154

mRNA Expression by UniProt/SwissProt for UGT2B28 Gene

Q9BY64-UDB28_HUMAN
Tissue specificity: Expressed in the liver, breast and kidney.
genes like me logo Genes that share expression patterns with UGT2B28: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for UGT2B28 Gene

Orthologs for UGT2B28 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B28 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ugt2b5 35
  • 72.34 (n)
  • 63.52 (a)
Ugt2b5 16
Ugt2b34 36
  • 67 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia UGT2B28 35
  • 93.7 (n)
  • 87.71 (a)
-- 36
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b 35
  • 70.83 (n)
  • 61.06 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia UGT2B31 36
  • 73 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10168 37
  • 24 (a)
CG10170 37
  • 24 (a)
CG15661 37
  • 30 (a)
CG17323 37
  • 26 (a)
Ugt35a 37
  • 30 (a)
Ugt35b 37
  • 33 (a)
Ugt36Bb 37
  • 28 (a)
Ugt36Bc 37
  • 25 (a)
Ugt37b1 37
  • 26 (a)
Ugt86Dd 37
  • 31 (a)
Ugt86Dg 37
  • 34 (a)
Ugt86Di 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea C03A7.11 37
  • 25 (a)
C18C4.3 37
  • 26 (a)
C44H9.1 37
  • 25 (a)
F39G3.1 37
  • 28 (a)
F56B3.7 37
  • 24 (a)
M88.1 37
  • 29 (a)
T03D3.1 37
  • 25 (a)
T19H12.11 37
  • 24 (a)
T25B9.7 37
  • 26 (a)
Y37E11AR.5 37
  • 25 (a)
ZC455.3 37
  • 23 (a)
Species with no ortholog for UGT2B28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B28 Gene

ENSEMBL:
Gene Tree for UGT2B28 (if available)
TreeFam:
Gene Tree for UGT2B28 (if available)

Paralogs for UGT2B28 Gene

Pseudogenes.org Pseudogenes for UGT2B28 Gene

genes like me logo Genes that share paralogs with UGT2B28: view

Variants for UGT2B28 Gene

Sequence variations from dbSNP and Humsavar for UGT2B28 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4235127 - 69,290,595(-) TTGGA(A/T)GACCT intron-variant, reference, missense
rs6843900 - 69,294,559(+) ATCAA(G/T)AATTC reference, missense, utr-variant-3-prime
rs6828191 - 69,294,591(+) CCCTG(C/G)ATCGA reference, missense, utr-variant-3-prime
rs2132039 -- 69,293,669(-) TTCTC(A/G)TCTTA intron-variant
rs4235125 -- 69,290,408(-) TGTGC(A/G)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B28 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
essv17788 CNV CNV 17122850
esv2727775 CNV Deletion 23290073
dgv1634e1 CNV Complex 17122850
dgv1635e1 CNV Complex 17122850
dgv1636e1 CNV Complex 17122850
dgv891e201 CNV Deletion 23290073
dgv5610n71 CNV Loss 21882294
dgv5611n71 CNV Gain 21882294
esv28328 CNV Gain+Loss 19812545
dgv1637e1 CNV Complex 17122850
nsv10524 CNV Gain+Loss 18304495
esv2670036 CNV Deletion 23128226
dgv17n31 CNV Duplication 19718026
essv5980 CNV CNV 17122850
nsv879390 CNV Gain+Loss 21882294
dgv5612n71 CNV Gain 21882294
nsv879395 CNV Loss 21882294
esv2727780 CNV Deletion 23290073
nsv879400 CNV Gain 21882294
dgv5613n71 CNV Gain 21882294
nsv436676 OTHER Inversion 17901297
dgv1638e1 CNV Complex 17122850
nsv820690 CNV Deletion 20802225
nsv822596 CNV Loss 20364138
nsv437922 CNV Loss 16468122
dgv1639e1 CNV Complex 17122850
dgv1640e1 CNV Complex 17122850
dgv5614n71 CNV Loss 21882294
nsv469562 CNV Loss 16826518
nsv471625 CNV Loss 15918152
nsv4374 CNV Loss 18451855
nsv436948 CNV Loss 16327808
dgv5615n71 CNV Loss 21882294
dgv5616n71 CNV Gain 21882294
dgv952e199 CNV Deletion 23128226
nsv499045 CNV Loss 21111241
esv33234 CNV Gain 17666407
nsv510922 CNV Complex 20534489
nsv514224 CNV Loss 21397061
esv2421696 CNV Deletion 20811451
nsv442911 CNV CNV 18776908
dgv92n16 CNV Deletion 17901297
dgv5617n71 CNV Gain+Loss 21882294
essv948 CNV CNV 17122850
dgv892e201 CNV Deletion 23290073
dgv5618n71 CNV Gain 21882294
nsv436949 CNV Loss 16327808
dgv878n67 CNV Loss 20364138
nsv822599 CNV Gain 20364138
esv29954 CNV Loss 18421352
esv33154 CNV Loss 17666407
dgv5619n71 CNV Loss 21882294

Variation tolerance for UGT2B28 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.98; 98.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2B28 Gene

HapMap Linkage Disequilibrium report
UGT2B28
Human Gene Mutation Database (HGMD)
UGT2B28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B28 Gene

Disorders for UGT2B28 Gene

Relevant External Links for UGT2B28

Genetic Association Database (GAD)
UGT2B28
Human Genome Epidemiology (HuGE) Navigator
UGT2B28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2B28

No disorders were found for UGT2B28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2B28 Gene

Publications for UGT2B28 Gene

  1. Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. (PMID: 11300766) Levesque E. … Belanger A. (Biochemistry 2001) 2 3 4 23 67
  2. Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study. (PMID: 21679149) Ohno S. … Nakajin S. (Drug Metab Lett 2011) 3
  3. Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer. (PMID: 20056642) Setlur S.R. … Demichelis F. (Cancer Epidemiol. Biomarkers Prev. 2010) 3
  4. Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism. (PMID: 19572376) MAcnard V. … LAcvesque E. (Hum. Mutat. 2009) 3
  5. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3

Products for UGT2B28 Gene

Sources for UGT2B28 Gene

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