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Aliases for UGT2B28 Gene

Aliases for UGT2B28 Gene

  • UDP Glucuronosyltransferase 2 Family, Polypeptide B28 2 3
  • EC 2.4.1.17 4 63
  • UDP Glycosyltransferase 2 Family, Polypeptide B28 2
  • UDPGT 2B28 4

External Ids for UGT2B28 Gene

Previous GeneCards Identifiers for UGT2B28 Gene

  • GC04M070372
  • GC04P070194
  • GC04P070396
  • GC04P070461
  • GC04P070327
  • GC04P065944

Summaries for UGT2B28 Gene

Entrez Gene Summary for UGT2B28 Gene

  • This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]

GeneCards Summary for UGT2B28 Gene

UGT2B28 (UDP Glucuronosyltransferase 2 Family, Polypeptide B28) is a Protein Coding gene. Diseases associated with UGT2B28 include gilbert syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2B28 Gene

  • UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B28 Gene

Genomics for UGT2B28 Gene

Regulatory Elements for UGT2B28 Gene

Genomic Location for UGT2B28 Gene

Start:
69,280,487 bp from pter
End:
69,423,402 bp from pter
Size:
142,916 bases
Orientation:
Plus strand

Genomic View for UGT2B28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT2B28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B28 Gene

Proteins for UGT2B28 Gene

  • Protein details for UGT2B28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY64-UDB28_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B28
    Protein Accession:
    Q9BY64
    Secondary Accessions:
    • B5BUM0
    • Q9BY62
    • Q9BY63

    Protein attributes for UGT2B28 Gene

    Size:
    529 amino acids
    Molecular mass:
    60906 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK31809.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for UGT2B28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2B28 Gene

Proteomics data for UGT2B28 Gene at MOPED

Post-translational modifications for UGT2B28 Gene

  • Glycosylation at Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B28 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UGT2B28 Gene

Gene Families for UGT2B28 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT2B28 Gene

Suggested Antigen Peptide Sequences for UGT2B28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY64

UniProtKB/Swiss-Prot:

UDB28_HUMAN :
  • Q9BY64
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B28: view

Function for UGT2B28 Gene

Molecular function for UGT2B28 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

Enzyme Numbers (IUBMB) for UGT2B28 Gene

Gene Ontology (GO) - Molecular Function for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IBA --
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT2B28: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT2B28 Gene

Localization for UGT2B28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B28 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B28 Gene COMPARTMENTS Subcellular localization image for UGT2B28 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
peroxisome 2
cytoskeleton 1
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 11300766
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT2B28: view

Pathways for UGT2B28 Gene

genes like me logo Genes that share pathways with UGT2B28: view

Pathways by source for UGT2B28 Gene

2 BioSystems pathways for UGT2B28 Gene
1 GeneGo (Thomson Reuters) pathway for UGT2B28 Gene

Interacting Proteins for UGT2B28 Gene

Gene Ontology (GO) - Biological Process for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006805 xenobiotic metabolic process IDA 11300766
GO:0008152 metabolic process IDA 11300766
GO:0009813 flavonoid biosynthetic process IBA --
GO:0030259 lipid glycosylation --
genes like me logo Genes that share ontologies with UGT2B28: view

Compounds for UGT2B28 Gene

(85) HMDB Compounds for UGT2B28 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available
genes like me logo Genes that share compounds with UGT2B28: view

Transcripts for UGT2B28 Gene

mRNA/cDNA for UGT2B28 Gene

Unigene Clusters for UGT2B28 Gene

UDP glucuronosyltransferase 2 family, polypeptide B28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B28 Gene

No ASD Table

Relevant External Links for UGT2B28 Gene

GeneLoc Exon Structure for
UGT2B28
ECgene alternative splicing isoforms for
UGT2B28

Expression for UGT2B28 Gene

mRNA expression in normal human tissues for UGT2B28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B28 Gene

This gene is overexpressed in Bladder (19.7), Liver (11.1), Skin - Not Sun Exposed (Suprapubic) (6.7), and Breast - Mammary Tissue (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2B28 Gene

SOURCE GeneReport for Unigene cluster for UGT2B28 Gene Hs.653154

mRNA Expression by UniProt/SwissProt for UGT2B28 Gene

Q9BY64-UDB28_HUMAN
Tissue specificity: Expressed in the liver, breast and kidney.
genes like me logo Genes that share expressions with UGT2B28: view

Orthologs for UGT2B28 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
OneToMany
UGT2B28 35
  • 93.7 (n)
  • 87.71 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia UGT2B31 36
  • 73 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt2b34 36
  • 67 (a)
ManyToMany
Ugt2b5 35
  • 72.34 (n)
  • 63.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b 35
  • 70.83 (n)
  • 61.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10168 37
  • 24 (a)
Ugt36Bb 37
  • 28 (a)
Ugt36Bc 37
  • 25 (a)
CG10170 37
  • 24 (a)
Ugt86Di 37
  • 29 (a)
Ugt86Dd 37
  • 31 (a)
Ugt35b 37
  • 33 (a)
CG15661 37
  • 30 (a)
Ugt37b1 37
  • 26 (a)
Ugt35a 37
  • 30 (a)
CG17323 37
  • 26 (a)
Ugt86Dg 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea F56B3.7 37
  • 24 (a)
Y37E11AR.5 37
  • 25 (a)
T03D3.1 37
  • 25 (a)
ZC455.3 37
  • 23 (a)
C03A7.11 37
  • 25 (a)
C44H9.1 37
  • 25 (a)
T25B9.7 37
  • 26 (a)
F39G3.1 37
  • 28 (a)
M88.1 37
  • 29 (a)
C18C4.3 37
  • 26 (a)
T19H12.11 37
  • 24 (a)
Species with no ortholog for UGT2B28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B28 Gene

ENSEMBL:
Gene Tree for UGT2B28 (if available)
TreeFam:
Gene Tree for UGT2B28 (if available)

Paralogs for UGT2B28 Gene

Pseudogenes.org Pseudogenes for UGT2B28 Gene

genes like me logo Genes that share paralogs with UGT2B28: view

Variants for UGT2B28 Gene

Sequence variations from dbSNP and Humsavar for UGT2B28 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2132039 -- 69,293,669(-) TTCTC(A/G)TCTTA intron-variant
rs3901337 -- 69,287,684(+) AGCAG(A/T)AGGAA intron-variant
rs4235125 -- 69,290,408(-) TGTGC(A/G)TAACT intron-variant
rs4235126 -- 69,290,428(-) TGTAA(C/T)TGAAG intron-variant
rs4235127 - 69,290,595(-) TTGGA(A/T)GACCT intron-variant, missense, reference

Structural Variations from Database of Genomic Variants (DGV) for UGT2B28 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
essv17788 CNV CNV 17122850
esv2727775 CNV Deletion 23290073
dgv1634e1 CNV Complex 17122850
dgv1635e1 CNV Complex 17122850
dgv1636e1 CNV Complex 17122850
dgv891e201 CNV Deletion 23290073
dgv5610n71 CNV Loss 21882294
dgv5611n71 CNV Gain 21882294
esv28328 CNV Gain+Loss 19812545
dgv1637e1 CNV Complex 17122850
nsv10524 CNV Gain+Loss 18304495
esv2670036 CNV Deletion 23128226
dgv17n31 CNV Duplication 19718026
essv5980 CNV CNV 17122850
nsv879390 CNV Gain+Loss 21882294
dgv5612n71 CNV Gain 21882294
nsv879395 CNV Loss 21882294
esv2727780 CNV Deletion 23290073
nsv879400 CNV Gain 21882294
dgv5613n71 CNV Gain 21882294
nsv436676 OTHER Inversion 17901297
dgv1638e1 CNV Complex 17122850
nsv820690 CNV Deletion 20802225
nsv822596 CNV Loss 20364138
nsv437922 CNV Loss 16468122
dgv1639e1 CNV Complex 17122850
dgv1640e1 CNV Complex 17122850
dgv5614n71 CNV Loss 21882294
nsv469562 CNV Loss 16826518
nsv471625 CNV Loss 15918152
nsv4374 CNV Loss 18451855
nsv436948 CNV Loss 16327808
dgv5615n71 CNV Loss 21882294
dgv5616n71 CNV Gain 21882294
dgv952e199 CNV Deletion 23128226
nsv499045 CNV Loss 21111241
esv33234 CNV Gain 17666407
nsv510922 CNV Complex 20534489
nsv514224 CNV Loss 21397061
esv2421696 CNV Deletion 20811451
nsv442911 CNV CNV 18776908
dgv92n16 CNV Deletion 17901297
dgv5617n71 CNV Gain+Loss 21882294
essv948 CNV CNV 17122850
dgv892e201 CNV Deletion 23290073
dgv5618n71 CNV Gain 21882294
nsv436949 CNV Loss 16327808
dgv878n67 CNV Loss 20364138
nsv822599 CNV Gain 20364138
esv29954 CNV Loss 18421352
esv33154 CNV Loss 17666407
dgv5619n71 CNV Loss 21882294

Relevant External Links for UGT2B28 Gene

HapMap Linkage Disequilibrium report
UGT2B28
Human Gene Mutation Database (HGMD)
UGT2B28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B28 Gene

Disorders for UGT2B28 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UGT2B28 Gene including...

Search for UGT2B28 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UGT2B28 Gene

Relevant External Links for UGT2B28

Genetic Association Database (GAD)
UGT2B28
Human Genome Epidemiology (HuGE) Navigator
UGT2B28
genes like me logo Genes that share disorders with UGT2B28: view

No data available for UniProtKB/Swiss-Prot for UGT2B28 Gene

Publications for UGT2B28 Gene

  1. Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. (PMID: 11300766) Levesque E. … Belanger A. (Biochemistry 2001) 2 3 4 23
  2. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 48
  3. Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer. (PMID: 20056642) Setlur S.R. … Demichelis F. (Cancer Epidemiol. Biomarkers Prev. 2010) 3
  4. Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study. (PMID: 21679149) Ohno S. … Nakajin S. (Drug Metab Lett 2011) 3
  5. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PMID: 19054851) Goshima N. … Nomura N. (Nat. Methods 2008) 4

Products for UGT2B28 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate UGT2B28
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for UGT2B28
    • Block miRNA regulation of UGT2B28 using miScript Target Protectors

    Sources for UGT2B28 Gene

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