Aliases for UGT2B17 Gene
- UDP Glucuronosyltransferase Family 2 Member B17 2 3 5
- C19-Steroid-Specific UDP-Glucuronosyltransferase 3 4
- C19-Steroid-Specific UDPGT 3 4
- EC 188.8.131.52 4 61
- UDP Glucuronosyltransferase 2 Family, Polypeptide B17 3
- UDP Glycosyltransferase 2 Family, Polypeptide B17 2
- UDP Glycosyltransferase 2 Family, Member B17 3
External Ids for UGT2B17 Gene
Previous GeneCards Identifiers for UGT2B17 Gene
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]
GeneCards Summary for UGT2B17 Gene
UGT2B17 (UDP Glucuronosyltransferase Family 2 Member B17) is a Protein Coding gene. Diseases associated with UGT2B17 include Bone Mineral Density Qtl 12, Osteoporosis and Ugt2b17-Related Altered Drug Metabolism. Among its related pathways are Porphyrin and chlorophyll metabolism and Drug metabolism - cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.
UniProtKB/Swiss-Prot for UGT2B17 Gene
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).