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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT2B17 Gene

protein-coding   GIFtS: 61
GCID: GC04M069406

UDP glucuronosyltransferase 2 family, polypeptide B17

(Previous names: UDP glycosyltransferase 2 family, polypeptide B17 )
 Explore 8 diseases affiliated with
UGT2B17 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UGT2B17    

Aliases
for UGT2B17 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B171 2     UDP Glycosyltransferase 2 Family, Member B172
C19-Steroid-Specific UDP-Glucuronosyltransferase2 3     UDP-Glucuronosyltransferase 2B172
C19-Steroid-Specific UDPGT2 3     UDP-Glucuronyltransferase, Family 2, Beta-172
EC 2.4.1.173 8     UDPGT 2B173
UDP Glycosyltransferase 2 Family, Polypeptide B171     EC 2.4.18
UDPGT2B172     

External Ids:    HGNC: 125471   Entrez Gene: 73672   Ensembl: ENSG000001978887   OMIM: 6019035   UniProtKB: O757953   

Export aliases for UGT2B17 gene to outside databases

Previous GC identifers: GC04U990053 GC04M069386 GC04M069231 GC04M069085


Summaries
for UGT2B17 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UGT2B17:
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes
the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including
steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the
metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.(provided
by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: UDB17_HUMAN, O75795
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone >
dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT)

Gene Wiki entry for UGT2B17


Genomic Views
for UGT2B17 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT2B17 gene promoter:
         PPAR-gamma1   HOXA3   PPAR-gamma2   CUTL1   IRF-1   En-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UGT2B17 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGT2B17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2B17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13

UGT2B17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B17 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M069406:  view genomic region     (about GC identifiers)

Start:
 69,402,902 bp from pter      End:
 69,434,245 bp from pter
Size:
 31,344 bases      Orientation:
 minus strand

Proteins
for UGT2B17 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UDB17_HUMAN, O75795 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2B17 precursor  
Size: 530 amino acids; 61095 Da
Subcellular location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane;
Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for UGT2B17: NX_O75795

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75795

    • 4/24 DME Specific Peptides for UGT2B17 (O75795) (see all 24)
     DLLNALK  AFITHGG  CGKVLVW  LLGHPKT 

    UGT2B17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001068.1  
    ENSEMBL proteins: 
     ENSP00000320401  
    Reactome Protein details: O75795
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    Uscn Proteins for UGT2B17

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005792microsome ----
    GO:0016020membrane TAS8798464
    GO:0016021integral to membrane IEA--


    UGT2B17 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UGT2B17

    Protein Domains /
    Families
    for UGT2B17 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UGT2B17 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry O75795

    ProtoNet protein and cluster: O75795

    1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UDB17_HUMAN, O75795
    Similarity: Belongs to the UDP-glycosyltransferase family


    Function
    for UGT2B17 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UDB17_HUMAN, O75795
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
    and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone >
    dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT)
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Genatlas biochemistry entry for UGT2B17:
    UDP-glucoronosyltransferase (B17),expressed in several extrahepatic steroid tissues,including prostate,active or C19
    steroids

    Enzyme Numbers (IUBMB): EC 2.4.1.171 2 EC 2.4.12

    miRNA
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    Inhib. RNA
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972NOT retinoic acid binding IDA--
    GO:0015020glucuronosyltransferase activity IEA--


    UGT2B17 for ontologies           About GeneDecksing



    Pathways & Interactions
    for UGT2B17 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    		Glucuronidation1.00
    		Porphyrin and chlorophyll metabolism0.38
    		Glucuronidation0.67
    		Other types of O-glycan biosynthesis0.36
    		Starch and sucrose metabolism0.42
    		Drug metabolism - other enzymes0.32
    2Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Retinol metabolism0.40
    		Metabolism of xenobiotics by cytochrome P4500.73
    3Biological oxidations
    		Biological oxidations1.00
    		metapathway biotransformation0.41
    		Phase II conjugation0.52
    4Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    5Pentose and glucuronate interconversions
    		Pentose and glucuronate interconversions1.00
    		Ascorbate and aldarate metabolism0.62

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for UGT2B17 
        Glucuronidation
    metapathway biotransformation

    4        Reactome Pathways for UGT2B17
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation


    5/11         Kegg Pathways  (Kegg details for UGT2B17) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Other types of O-glycan biosynthesis


    UGT2B17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT2B17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT2B17 (ENSP000003204014) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    COMTENSP000003545114STRING: ENSP00000354511
    CYP19A1ENSP000002604334STRING: ENSP00000260433
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008202steroid metabolic process TAS8798464


    UGT2B17 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UGT2B17 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT2B17 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT2B17

    10/86 HMDB Compounds for UGT2B17 (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-89364925
    Ethyl glucuronide 17685-04-016139098
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--

    1 DrugBank Compound for UGT2B17    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LosartanDUP 89 (see all 2)114798-26-4enzymesubstrate19515014

    10/11 Novoseek chemical compound relationships for UGT2B17 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol 77.4 1 17416778 (1)
    dihydrotestosterone 72.9 24 9364925 (3), 9154505 (2), 17698910 (2), 9202245 (2) (see all 11)
    uridine diphosphate 68.8 2 8131219 (1), 19572376 (1)
    uridine 66.7 4 20429943 (1), 8798464 (1), 9202245 (1), 17826523 (1)
    testosterone 64.3 39 9154505 (6), 17698910 (4), 16332934 (3), 19088161 (3) (see all 11)
    steroid 56.5 16 9564848 (2), 20429943 (2), 11159850 (2), 19487245 (1) (see all 8)
    4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 54.9 2 17416778 (1)
    glucuronic acid 47.6 1 19224506 (1)
    cycloheximide 14.6 1 11159850 (1)
    tamoxifen 12.9 2 15135306 (1), 16480962 (1)

    Search CenterWatch for drugs/clinical trials and news about UGT2B17 / UDB17 

    Transcripts
    for UGT2B17 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UGT2B17 gene: 
    NM_001077.3  

    Unigene Cluster for UGT2B17:

    UDP glucuronosyltransferase 2 family, polypeptide B17
    Hs.575083  [show with all ESTs]
    Unigene Representative Sequence: U59209
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000317746(uc021xov.1)

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    Additional cDNA sequence: U59209.1 

    3 DOTS entries:

    DT.40257588  DT.92423054  DT.102821119 

    16 AceView cDNA sequences:

    BG196369 BG207750 NM_001077 U59209 BG204559 AI802786 BX104868 BG205096 
    BG204560 BG206197 BG189722 BG197852 BF767899 BG198908 BG212981 BG181243 

    GeneLoc Exon Structure


    Expression
    for UGT2B17 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT2B17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGGGTTTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UGT2B17 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UGT2B17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT2B17

    SOURCE GeneReport for Unigene cluster: Hs.575083

    UniProtKB/Swiss-Prot: UDB17_HUMAN, O75795
    Tissue specificity: Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland,
    adrenal gland, skin and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including UGT2B17: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
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    Orthologs
    for UGT2B17 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UGT2B17 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NMB3_CHICK6
    		 Uncharacterized protein
    		 59(a)
    		 1 → many
    		 4(53288491-53295396)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 60(a)
    59(a)
    		 many ↔ many
    many ↔ many
    		 6(58629882-58649612)
    6(58564243-58578541)
    zebrafish
    (Danio rerio)    		 Actinopterygii BX571679.16
    FP236810.46
    (see all 15)    		 --
    		 64(a)
    55(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 5(9986135-9988976)
    5(9898582-9908402)


    ENSEMBL Gene Tree for UGT2B17 (if available)
    TreeFam Gene Tree for UGT2B17 (if available) 

    Paralogs
    for UGT2B17 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT2B17 gene
    UGT2A22  UGT1A82  UGT1A72  UGT3A12  UGT2B72  UGT2B112  UGT1A32  UGT1A12  
    UGT1A52  UGT3A22  UGT2B102  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B282  UGT1A92  UGT1A42  
    18/27 SIMAP similar genes for UGT2B17 using alignment to 1 protein entry:     UDB17_HUMAN(see all similar genes):
    UGT2B15    UGT2B11    UGT2B4    UGT2B7    UGT2B28    UGT2A3
    UGT1A3S    UGT1A9S    UGT2B10    UGT2A1    UGT1A8S    UGT1A5
    BILIQTL1    UGT1A8    UGT1A1    UGT1A6    UGT1A7    UGT1A4

    UGT2B17 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for UGT2B17
    PGOHUM00000259904 PGOHUM00000245945


    Genomic Variants
    for UGT2B17 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: UDB17_HUMAN, O75795
    Polymorphism: Copy-number variation of UGT2B17 defines the bone mineral density quantitative trait locus 12 (BMND12)
    [MIM:612560]. Variance in bone mineral density is a susceptibility factor for osteoporotic fractures


    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for UGT2B17
         14 CNVs: 1388 92178 7448 31177 1082 92179 3499 38138 1389 92177 63852 23279 1083 38966
    Human Gene Mutation Database (HGMD): UGT2B17

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    Disorders / Diseases
    for UGT2B17 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UGT2B17 for disorders           About GeneDecksing

    OMIM gene information: 601903    OMIM disorders: --

    8 diseases for UGT2B17:    About MalaCards
    graft versus host disease    osteoporosis    prostate cancer    endometrial cancer
    lung cancer    prostatitis    cholesterol    osteoporotic fracture

    1 disease from the University of Copenhagen DISEASES database for UGT2B17:
    Prostate cancer

    4 Novoseek disease relationships for UGT2B17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 49.2 24 17826523 (5), 18247404 (5), 16896035 (4), 17935910 (4) (see all 7)
    graft-versus-host disease 42.2 2 15813850 (1), 17496542 (1)
    cancer lung 0 3 17416778 (2)
    cancer 0 2 1944327 (1), 16220109 (1)

    Human Genome Epidemiology (HuGE) Navigator: UGT2B17 (27 documents)

    Export disorders for UGT2B17 gene to outside databases

    Publications
    for UGT2B17 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT2B17 gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with UGT2B17)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. (PubMed id 9364925)1, 2, 6, 9 Beaulieu M....Hum D.W. (1997)
    2. Isolation and characterization of a novel cDNA encoding a human UDP- glucuronosyltransferase active on C19 steroids. (PubMed id 8798464)1, 2, 3, 9 Beaulieu M.... Belanger A. (1996)
    3. Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. (PubMed id 18992858)1, 2, 9 Yang T.-L....Deng H.-W. (2008)
    4. Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids. (PubMed id 20429943)1, 9 Deshmukh N....Naughton D.P. (2010)
    5. Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes. (PubMed id 16220109)1, 9 Lazarus P....Wiener D. (2005)
    6. A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys. (PubMed id 19088161)1, 9 Juul A....Ottesen A.M. (2009)
    7. Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate. (PubMed id 17387331)1, 9 Karypidis A.H....Ekstrom L. (2008)
    8. Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk. (PubMed id 17826523)1, 9 Park J.Y....Pow-Sang J. (2007)
    9. Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men. (PubMed id 16896035)1, 9 Park J....Pow-Sang J. (2006)
    10. The UGT2B17 gene deletion is not associated with prostate cancer risk. (PubMed id 18247404)1, 9 Olsson M....Gronberg H. (2008)

    External Searches for UGT2B17 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing UGT2B17 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7367 HGNC: 12547 AceView: UGT2B17 Ensembl:ENSG00000197888 euGenes: HUgn7367
    ECgene: UGT2B17 Kegg: 7367 H-InvDB: UGT2B17

    Other Databases showing UGT2B17 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UGT2B17 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT2B17 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UGT2B17 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UGT2B17 gene:
    Search GeneIP for patents involving UGT2B17

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