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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT2B15 Gene

protein-coding   GIFtS: 64
GCID: GC04M069561

UDP glucuronosyltransferase 2 family, polypeptide B15

(Previous names: UDP glycosyltransferase 2 family, polypeptide B15 )
 Explore 16 diseases affiliated with
UGT2B15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UGT2B15    

Aliases
for UGT2B15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B151 2     UDP Glycosyltransferase 2 Family, Polypeptide B151
UGT2B81 2 3 5     UDPGT2B152
HLUG42 3     UDPGTH32
UDPGTh-32 3     UDP Glycosyltransferase 2B152
UDP-Glucuronosyltransferase 2B82 3     UDP-Glucuronosyltransferase 2B152
UDPGT 2B152 3     UDP-Glucuronosyltransferase UGT2B152
UDPGT 2B82 3     UDP-Glucuronyltransferase, Family 2, Beta-152
EC 2.4.1.173 8     EC 2.4.18

External Ids:    HGNC: 125461   Entrez Gene: 73662   Ensembl: ENSG000001966207   OMIM: 6000695   UniProtKB: P548553   

Export aliases for UGT2B15 gene to outside databases

Previous GC identifers: GC04M069423 GC04M069762 GC04M069827 GC04M069407 GC04M069693 GC04M065308


Summaries
for UGT2B15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UGT2B15:
This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the
conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein
displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds,
7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also
catalyzes the glucuronidation of endogenous estrogens and androgens. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855
Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including
simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their
hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

Gene Wiki entry for UGT2B15


Genomic Views
for UGT2B15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  NT_167250.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT2B15 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   FOXO1a   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UGT2B15 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGT2B15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2B15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13

UGT2B15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B15 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M069561:  view genomic region     (about GC identifiers)

Start:
 69,512,315 bp from pter      End:
 69,536,374 bp from pter
Size:
 24,060 bases      Orientation:
 minus strand

2 alternative locations:
Chr4- 69,394,991-69,419,037      Chr4-,ALT_REF_LOCI_8 69,453,826-69,477,873     

Proteins
for UGT2B15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2B15 precursor  
Size: 530 amino acids; 61036 Da
Subcellular location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane;
Single-pass membrane protein (Potential)
Caution: PubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a rat
enzyme
Secondary accessions: A6NDX0 A6NNJ4 P23765 Q9UK63

Explore the universe of human proteins at neXtProt for UGT2B15: NX_P54855

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54855

    • 4/27 DME Specific Peptides for UGT2B15 (P54855) (see all 27)
     DLLNALK  AFITHGG  CGKVLVW  LLGHPKT 

    UGT2B15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001067.2  
    ENSEMBL proteins: 
     ENSP00000341045  
    Reactome Protein details: P54855
    Human Recombinant Protein Products: 
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    Uscn Proteins for UGT2B15

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--


    UGT2B15 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UGT2B15

    Protein Domains /
    Families
    for UGT2B15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UGT2B15 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P54855

    ProtoNet protein and cluster: P54855

    1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855
    Similarity: Belongs to the UDP-glycosyltransferase family


    Function
    for UGT2B15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855
    Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
    and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including
    simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their
    hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Genatlas biochemistry entry for UGT2B15:
    UDP glucuronosyltransferase subfamily 2,liver specific,conjugating bile acid

    Enzyme Numbers (IUBMB): EC 2.4.1.171 2 EC 2.4.12

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972NOT retinoic acid binding IDA--
    GO:0015020glucuronosyltransferase activity IDA--


    UGT2B15 for ontologies           About GeneDecksing



    Pathways & Interactions
    for UGT2B15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    		Glucuronidation1.00
    		Porphyrin and chlorophyll metabolism0.38
    		Glucuronidation0.67
    		Other types of O-glycan biosynthesis0.36
    		Starch and sucrose metabolism0.42
    		Drug metabolism - other enzymes0.32
    2Acetaminophen Pathway, Pharmacokinetics
    		Pathway_PA165986194 -need delete1.00
    		Acetaminophen metabolism0.43
    		Acetaminophen Pathway, Pharmacokinetics1.00
    		Acetaminophen metabolism0.43
    3Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Retinol metabolism0.40
    		Metabolism of xenobiotics by cytochrome P4500.73
    4Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    5Pentose and glucuronate interconversions
    		Pentose and glucuronate interconversions1.00
    		Ascorbate and aldarate metabolism0.62

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for UGT2B15
        Acetaminophen metabolism


    1 GeneGo (Thomson Reuters) Pathway for UGT2B15
        Acetaminophen metabolism

    1 BioSystems Pathway for UGT2B15 
        Glucuronidation

    4        Reactome Pathways for UGT2B15
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation

    5 PharmGKB Pathways for UGT2B15
        Acetaminophen Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Pathway_PA165986194 -need delete
    Tamoxifen Pathway, Pharmacokinetics
    Valproic Acid Pathway, Pharmacokinetics

    5/11         Kegg Pathways  (Kegg details for UGT2B15) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Other types of O-glycan biosynthesis


    UGT2B15 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT2B15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT2B15 (ENSP000003410454) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH7ENSP000002096654STRING: ENSP00000209665
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    AKR1D1ENSP000002423754STRING: ENSP00000242375
    COMTENSP000003545114STRING: ENSP00000354511
    CYP19A1ENSP000002604334STRING: ENSP00000260433
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS7835232
    GO:0008202steroid metabolic process TAS7835232
    GO:0052695cellular glucuronidation IDA--


    UGT2B15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UGT2B15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT2B15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT2B15

    10/85 HMDB Compounds for UGT2B15 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ethyl glucuronide 17685-04-016139098
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    10/21 Novoseek chemical compound relationships for UGT2B15 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucuronide 83.7 1 11560872 (1)
    uridine diphosphate 75.7 3 12376738 (2), 18161889 (1)
    dihydrotestosterone 73.1 9 11129427 (1), 9569009 (1), 15126881 (1), 16595710 (1) (see all 7)
    uridine 63.6 3 16513443 (1), 9202245 (1), 18496127 (1)
    glucuronic acid 61.1 2 19224506 (1), 16690804 (1)
    testosterone 56.7 17 18302198 (5), 9622078 (2), 18467088 (1), 17507624 (1) (see all 7)
    steroid 51.5 14 9564848 (2), 11159850 (2), 10623541 (2), 9622078 (1) (see all 8)
    naringenin 48.9 1 7835232 (1)
    imipramine 46.8 1 12019188 (1)
    eugenol 46.1 1 7835232 (1)

    1 PharmGKB related drug/compound annotation for UGT2B15 gene
    Drug/compound PharmGKB Annotation
    oxazepamCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about UGT2B15 / UDB15 

    Transcripts
    for UGT2B15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UGT2B15 gene: 
    NM_001076.3  

    Unigene Cluster for UGT2B15:

    UDP glucuronosyltransferase 2 family, polypeptide B15
    Hs.150207  [show with all ESTs]
    Unigene Representative Sequence: NM_001076
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000338206(uc021xow.1)

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    Clone
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    Additional cDNA sequence: 

    AF180322.1 AF548389.1 AK289419.1 U06641.1 U08854.1 

    3 DOTS entries:

    DT.102821119  DT.207081  DT.92423056 

    11 AceView cDNA sequences:

    AF180322 AF548389 CD610480 U08854 BX444042 NM_001076 BM127766 CB160073 
    BM128031 BG876589 U06641 

    GeneLoc Exon Structure


    Expression
    for UGT2B15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT2B15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAACAACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UGT2B15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UGT2B15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT2B15

    SOURCE GeneReport for Unigene cluster: Hs.150207

    UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855
    Tissue specificity: Expressed in many tissues. Present in liver, prostate and testis

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    In Situ
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    Orthologs
    for UGT2B15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UGT2B15 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NMB3_CHICK6
    		 Uncharacterized protein
    		 60(a)
    		 1 → many
    		 4(53288491-53295396)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 60(a)
    58(a)
    		 many ↔ many
    many ↔ many
    		 6(58629882-58649612)
    6(58564243-58578541)
    zebrafish
    (Danio rerio)    		 Actinopterygii BX571679.16
    FP236810.46
    (see all 15)    		 --
    		 65(a)
    56(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 5(9986135-9988976)
    5(9898582-9908402)


    ENSEMBL Gene Tree for UGT2B15 (if available)
    TreeFam Gene Tree for UGT2B15 (if available) 

    Paralogs
    for UGT2B15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT2B15 gene
    UGT2A22  UGT1A82  UGT1A72  UGT3A12  UGT2B72  UGT2B112  UGT1A32  UGT1A12  
    UGT1A52  UGT3A22  UGT2B102  UGT1A102  UGT1A62  UGT82  UGT2B42  UGT2B172  
    UGT2A32  UGT2B282  UGT1A92  UGT1A42  
    18/30 SIMAP similar genes for UGT2B15 using alignment to 4 protein entries:     UDB15_HUMAN (see all proteins) (see all similar genes):
    UGT2B17    UGT2B11    UGT2B4    UGT2B28    UGT2B7    UGT2A3
    UGT1A3S    UGT1A9S    UGT2B10    UGT2A1    UGT1A8S    BILIQTL1
    UGT1A1    UGT1A6    UGT1A10    UGT8    UGT1A4S    UGT1

    UGT2B15 for paralogs           About GeneDecksing



    Genomic Variants
    for UGT2B15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for UGT2B15
         15/16 CNVs (see all 16): 80349 1388 1082 38138 1389 63852 23279 92181 1083 38966 92178 7448 31177 92179 3499
    Human Gene Mutation Database (HGMD): UGT2B15
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT2B15
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT2B15

    Disorders / Diseases
    for UGT2B15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UGT2B15 for disorders           About GeneDecksing

    OMIM gene information: 600069    OMIM disorders: --

    16 diseases for UGT2B15:    About MalaCards
    estrogen-receptor positive breast cancer    familial adenomatous polyposis    gilbert syndrome    hearing loss
    familial prostate cancer    hyperandrogenism    polyposis    prostate cancer
    breast cancer    duodenitis    prostatitis    prostate carcinoma
    cholesterol    carcinoma    hepatitis    alcoholism

    2 diseases from the University of Copenhagen DISEASES database for UGT2B15:
    Prostate cancer     Gilbert syndrome

    4 Novoseek disease relationships for UGT2B15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 48.8 11 15126881 (3), 9564848 (1), 17848572 (1), 18302198 (1) (see all 7)
    breast cancer 16.4 3 17244352 (2), 16690804 (1)
    tumors 0 3 15318931 (2), 18302198 (1)
    cancer 0 1 17848572 (1)

    Genetic Association Database (GAD): UGT2B15
    Human Genome Epidemiology (HuGE) Navigator: UGT2B15 (24 documents)

    Export disorders for UGT2B15 gene to outside databases

    Publications
    for UGT2B15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT2B15 gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with UGT2B15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A major genotype in UDP-glucuronosyltransferase 2B15. (PubMed id 15618667)1, 2, 4, 9 Toide K....Kamataki T. (2002)
    2. Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer. (PubMed id 15126881)1, 4, 9 Park J....Pow-Sang J. (2004)
    3. Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. (PubMed id 7835232)1, 2, 9 Green M.D.... Tephly T.R. (1994)
    4. An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer. (PubMed id 11129427)1, 4, 9 MacLeod S.L....Lang N.P. (2000)
    5. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PubMed id 15318931)1, 4, 9 Sparks R....McTiernan A. (2004)
    6. Isolation and characterization of UGT2B15(Y85): a UDP- glucuronosyltransferase encoded by a polymorphic gene. (PubMed id 9295060)1, 2, 9 Levesque E....Hum D.W. (1997)
    7. UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. (PubMed id 15044558)1, 4, 9 Court M.H....Greenblatt D.J. (2004)
    8. Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13. (PubMed id 7835904)1, 3, 9 Monaghan G....Burchell B. (1994)
    9. Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. (PubMed id 15961980)1, 4 Chung J.Y....Shin S.G. (2005)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)

    External Searches for UGT2B15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UGT2B15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7366 HGNC: 12546 AceView: UGT2B15.1 Ensembl:ENSG00000196620 euGenes: HUgn7366
    ECgene: UGT2B15 Kegg: 7366 H-InvDB: UGT2B15

    Other Databases showing UGT2B15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UGT2B15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT2B15 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UGT2B15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UGT2B15 gene:
    Search GeneIP for patents involving UGT2B15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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