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UGT2B15 Gene

protein-coding   GIFtS: 63
GCID: GC04M069561

UDP Glucuronosyltransferase 2 Family, Polypeptide B15

(Previous names: UDP glycosyltransferase 2 family, polypeptide B15)
  See UGT2B15-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B151 2     UDP Glycosyltransferase 2 Family, Polypeptide B151
UGT2B82 3 5     UDPGT2B152
HLUG42 3     UDPGTH32
UDPGTh-32 3     UDP Glycosyltransferase 2B152
UDP-Glucuronosyltransferase 2B82 3     UDP-Glucuronosyltransferase 2B152
UDPGT 2B152 3     UDP-Glucuronosyltransferase UGT2B152
UDPGT 2B82 3     UDP-Glucuronyltransferase, Family 2, Beta-152
EC 2.4.1.173 8     EC 2.4.18

External Ids:    HGNC: 125461   Entrez Gene: 73662   Ensembl: ENSG000001966207   OMIM: 6000695   UniProtKB: P548553   

Export aliases for UGT2B15 gene to outside databases

Previous GC identifers: GC04M069423 GC04M069762 GC04M069827 GC04M069407 GC04M069693 GC04M065308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UGT2B15 Gene:
This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in
the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This
protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds,
7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It
also catalyzes the glucuronidation of endogenous estrogens and androgens. (provided by RefSeq, Oct 2011)

GeneCards Summary for UGT2B15 Gene:
UGT2B15 (UDP glucuronosyltransferase 2 family, polypeptide B15) is a protein-coding gene. Diseases associated with UGT2B15 include gilbert syndrome, and familial prostate cancer. GO annotations related to this gene include retinoic acid binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855
Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic
substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and
certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens
and androgens

Gene Wiki entry for UGT2B15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  NT_167250.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UGT2B15 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   FOXO1a   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UGT2B15 promoter sequence
   Search Chromatin IP Primers for UGT2B15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT2B15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13

UGT2B15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B15 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M069561:  view genomic region     (about GC identifiers)

Start:
69,512,315 bp from pter      End:
69,536,374 bp from pter
Size:
24,060 bases      Orientation:
minus strand

2 alternative locations:
Chr4- 69,394,991-69,419,037      Chr4-,NT_167250 224,914-248,961     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2B15 precursor  
Size: 530 amino acids; 61036 Da
Caution: PubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a
rat enzyme
Secondary accessions: A6NDX0 A6NNJ4 P23765 Q9UK63

Explore the universe of human proteins at neXtProt for UGT2B15: NX_P54855

Explore proteomics data for UGT2B15 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn316, Asn483
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGT2B15 (P54855) (see all 27)
     DLLNALK  AFITHGG  CGKVLVW  LLGHPKT 


    See UGT2B15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001067.2  
    ENSEMBL proteins: 
     ENSP00000341045  
    Reactome Protein details: P54855

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P54855

    ProtoNet protein and cluster: P54855

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855
    Similarity: Belongs to the UDP-glycosyltransferase family


    Find genes that share domains with UGT2B15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UDB15_HUMAN, P54855
    Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic
    substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and
    certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens
    and androgens
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Genatlas biochemistry entry for UGT2B15:
    UDP glucuronosyltransferase subfamily 2,liver specific,conjugating bile acid

         Enzyme Numbers (IUBMB): EC 2.4.1.171 2 EC 2.4.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972NOT retinoic acid binding IDA--
    GO:0015020glucuronosyltransferase activity IDA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    Find genes that share ontologies with UGT2B15           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UDB15_HUMAN, P54855: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum
    membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus2
    peroxisome2
    cytosol1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UGT2B15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGT2B15 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Benzodiazepine Pathway, Pharmacokinetics0.00
    Phase II conjugation0.56
    Acetaminophen metabolism0.00
    Glucuronidation0.00
    Tamoxifen Pathway, Pharmacokinetics0.00
    2Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    5Metabolism of porphyrins
    Porphyrin and chlorophyll metabolism0.56


    Find genes that share SuperPaths with UGT2B15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for UGT2B15
        Acetaminophen metabolism

    1 BioSystems Pathway for UGT2B15
        Glucuronidation

    1 Reactome Pathway for UGT2B15
        Glucuronidation

    4 PharmGKB Pathways for UGT2B15
        Acetaminophen Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Tamoxifen Pathway, Pharmacokinetics
    Valproic Acid Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for UGT2B15) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UGT2B15
    Interactions:

        GeneGlobe Interaction Network for UGT2B15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT2B15 (ENSP000003410454) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH7ENSP000002096654STRING: ENSP00000209665
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    AKR1D1ENSP000002423754STRING: ENSP00000242375
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006805xenobiotic metabolic process TAS7835232
    GO:0008152metabolic process ----
    GO:0008202steroid metabolic process TAS7835232
    GO:0030259lipid glycosylation ----

    Find genes that share ontologies with UGT2B15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT2B15 (UDB15)

    Selected HMDB Compounds for UGT2B15 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ethyl glucuronide 17685-04-016139098
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--

    Selected Novoseek inferred chemical compound relationships for UGT2B15 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucuronide 83.7 1 11560872 (1)
    uridine diphosphate 75.7 3 12376738 (2), 18161889 (1)
    dihydrotestosterone 73.1 9 11129427 (1), 9569009 (1), 15126881 (1), 16595710 (1) (see all 7)
    uridine 63.6 3 16513443 (1), 9202245 (1), 18496127 (1)
    glucuronic acid 61.1 2 19224506 (1), 16690804 (1)
    testosterone 56.7 17 18302198 (5), 9622078 (2), 18467088 (1), 17507624 (1) (see all 7)
    steroid 51.5 14 9564848 (2), 11159850 (2), 10623541 (2), 9622078 (1) (see all 8)
    naringenin 48.9 1 7835232 (1)
    imipramine 46.8 1 12019188 (1)
    eugenol 46.1 1 7835232 (1)

    3 PharmGKB related drug/compound annotations for UGT2B15 gene    About this table
    Drug/compound PharmGKB Annotation
    eltrombopag
    oxazepamCA  
    sipoglitazarCA  



    Find genes that share compounds with UGT2B15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UGT2B15 gene: 
    NM_001076.3  

    Unigene Cluster for UGT2B15:

    UDP glucuronosyltransferase 2 family, polypeptide B15
    Hs.150207  [show with all ESTs]
    Unigene Representative Sequence: NM_001076
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000338206(uc021xow.1)
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    Additional mRNA sequence: 

    AF180322.1 AF548389.1 AK289419.1 U06641.1 U08854.1 

    3 DOTS entries:

    DT.102821119  DT.207081  DT.92423056 

    11 AceView cDNA sequences:

    CD610480 AF548389 BM127766 U08854 NM_001076 BX444042 AF180322 CB160073 
    BG876589 BM128031 U06641 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UGT2B15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACAACTT
    UGT2B15 Expression
    About this image


    UGT2B15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
    UGT2B15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT2B15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150207

    UniProtKB/Swiss-Prot: UDB15_HUMAN, P54855
    Tissue specificity: Expressed in many tissues. Present in liver, prostate and testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for UGT2B15 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt2b385 UDP glucuronosyltransferase 2 family, polypeptide B38   --   5 (43.56 cM) 87409942 


    ENSEMBL Gene Tree for UGT2B15 (if available)
    TreeFam Gene Tree for UGT2B15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGT2B15 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  
    UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    Selected SIMAP similar genes for UGT2B15 using alignment to 3 protein entries:     UDB15_HUMAN (see all proteins) (see all similar genes):
    UGT2B17    UGT2B11    UGT2B4    UGT2B28    UGT2B7    UGT1A3S
    UGT1A9S    UGT2A3    UGT2B10    UGT2A2    UGT2A1    UGT1A8S
    BILIQTL1    UGT1A1    UGT1A6    UGT1A10    UGT8    UGT1

    Find genes that share paralogs with UGT2B15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UGT2B15 (see all 685)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395275521,2
    C--69511925(+) TTGCCC/TTGCTT 1 -- ds50010--------
    rs131453461,2
    C,A--69511936(+) cagctC/Tacaca 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1471281021,2
    --69511952(+) TGCTGA/CACCCA 1 -- ds50010--------
    rs1486934011,2
    --69511963(+) CTGTCC/TTGTGC 1 -- ds50010--------
    rs1843019041,2
    --69511989(+) CCTTAG/TTGAGA 1 -- ds50010--------
    rs1901810781,2
    C--69512032(+) TCACCC/TGTCTT 1 -- ds50010--------
    rs1822111351,2
    --69512074(+) GAGCTC/GTTCCT 1 -- ds50010--------
    rs1422422801,2
    C--69512083(+) CTATTC/TGGTCA 1 -- ds50010--------
    rs76607191,2
    C,F,A,H--69512194(+) ATGTTG/CATACT 1 -- ds50011Minor allele frequency- C:0.50NA 4
    rs1855874621,2
    --69512227(+) TTGTGC/TTCAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for UGT2B15 (69512315 - 69536374 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGT2B15 (see all 53):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421501CNV Deletion20811451
    esv2727770CNV Deletion23290073
    nsv820369CNV Deletion20802225
    dgv890e201CNV Deletion23290073
    esv2669141CNV Deletion23128226
    dgv951e199CNV Deletion23128226
    dgv5598n71CNV Loss21882294
    nsv436941CNV Loss16327808
    nsv822582CNV Loss20364138
    dgv89n17CNV Loss16327808

    Human Gene Mutation Database (HGMD): UGT2B15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT2B15
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT2B15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600069    OMIM disorders: --

    3 diseases for UGT2B15:    
    About MalaCards
    gilbert syndrome    familial prostate cancer    prostate cancer

    2 diseases from the University of Copenhagen DISEASES database for UGT2B15:
    Gilbert syndrome     Prostate cancer

    Find genes that share disorders with UGT2B15           About GenesLikeMe

    4 Novoseek inferred disease relationships for UGT2B15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 48.8 11 15126881 (3), 9564848 (1), 17848572 (1), 18302198 (1) (see all 7)
    breast cancer 16.4 3 17244352 (2), 16690804 (1)
    tumors 0 3 15318931 (2), 18302198 (1)
    cancer 0 1 17848572 (1)

    Genetic Association Database (GAD): UGT2B15
    Human Genome Epidemiology (HuGE) Navigator: UGT2B15 (24 documents)

    Export disorders for UGT2B15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGT2B15 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with UGT2B15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A major genotype in UDP-glucuronosyltransferase 2B15. (PubMed id 15618667)1, 2, 4, 9 Toide K....Kamataki T. (Drug Metab. Pharmacokinet. 2002)
    2. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. (PubMed id 17244352)1, 4, 9 Wegman P....Wingren S. (Breast Cancer Res. 2007)
    3. Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion. (PubMed id 19916996)1, 4, 9 He X....Court M.H. (Br J Clin Pharmacol 2009)
    4. Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer. (PubMed id 15126881)1, 4, 9 Park J....Pow-Sang J. (J. Urol. 2004)
    5. Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. (PubMed id 7835232)1, 2, 9 Green M.D.... Tephly T.R. (Drug Metab. Dispos. 1994)
    6. Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes. (PubMed id 18496127)1, 4, 9 Schulze J.J....EkstrAPm L. (Pharmacogenet. Genomics 2008)
    7. An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer. (PubMed id 11129427)1, 4, 9 MacLeod S.L....Lang N.P. (Ann. Surg. Oncol. 2000)
    8. Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population. (PubMed id 16859836)1, 4, 9 Okugi H....Suzuki K. (Cancer Detect. Prev. 2006)
    9. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PubMed id 15318931)1, 4, 9 Sparks R....McTiernan A. (Breast Cancer Res. 2004)
    10. Isolation and characterization of UGT2B15(Y85): a UDP- glucuronosyltransferase encoded by a polymorphic gene. (PubMed id 9295060)1, 2, 9 Levesque E....Hum D.W. (Pharmacogenetics 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7366 HGNC: 12546 AceView: UGT2B15.1 Ensembl:ENSG00000196620 euGenes: HUgn7366
    ECgene: UGT2B15 Kegg: 7366 H-InvDB: UGT2B15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UGT2B15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UGT2B15 gene:
    Search GeneIP for patents involving UGT2B15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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