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Aliases for UGT2B15 Gene

Aliases for UGT2B15 Gene

  • UDP Glucuronosyltransferase 2 Family, Polypeptide B15 2 3
  • UGT2B8 3 4 6
  • UDP-Glucuronosyltransferase 2B8 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 2B15 3 4
  • UDPGT 2B8 3 4
  • UDPGTh-3 3 4
  • HLUG4 3 4
  • UDP Glycosyltransferase 2 Family, Polypeptide B15 2
  • UDP-Glucuronyltransferase, Family 2, Beta-15 3
  • UDP-Glucuronosyltransferase UGT2B15 3
  • UDP-Glucuronosyltransferase 2B15 3
  • UDP Glycosyltransferase 2B15 3
  • UDPGT2B15 3
  • EC 2.4.1 63
  • UDPGTH3 3

External Ids for UGT2B15 Gene

Summaries for UGT2B15 Gene

Entrez Gene Summary for UGT2B15 Gene

  • This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. [provided by RefSeq, Oct 2011]

GeneCards Summary for UGT2B15 Gene

UGT2B15 (UDP Glucuronosyltransferase 2 Family, Polypeptide B15) is a Protein Coding gene. Diseases associated with UGT2B15 include gilbert syndrome and prostate cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include glucuronosyltransferase activity and retinoic acid binding. An important paralog of this gene is UGT2B4.

UniProtKB/Swiss-Prot for UGT2B15 Gene

  • UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

Gene Wiki entry for UGT2B15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B15 Gene

Genomics for UGT2B15 Gene

Genomic Location for UGT2B15 Gene

Start:
68,537,413 bp from pter
End:
68,670,776 bp from pter
Size:
133,364 bases
Orientation:
Minus strand

Genomic View for UGT2B15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT2B15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B15 Gene

Regulatory Elements for UGT2B15 Gene

Proteins for UGT2B15 Gene

  • Protein details for UGT2B15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54855-UDB15_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B15
    Protein Accession:
    P54855
    Secondary Accessions:
    • A6NDX0
    • A6NNJ4
    • A8K054
    • P23765
    • Q9UK63

    Protein attributes for UGT2B15 Gene

    Size:
    530 amino acids
    Molecular mass:
    61036 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UGT2B15 Gene

Proteomics data for UGT2B15 Gene at MOPED

Post-translational modifications for UGT2B15 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn65, Asn316, and Asn483

Other Protein References for UGT2B15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UGT2B15 Gene

Gene Families for UGT2B15 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT2B15 Gene

Suggested Antigen Peptide Sequences for UGT2B15 Gene

Graphical View of Domain Structure for InterPro Entry

P54855

UniProtKB/Swiss-Prot:

UDB15_HUMAN
Family:
  • Belongs to the UDP-glycosyltransferase family.:
    • P54855
genes like me logo Genes that share domains with UGT2B15: view

Function for UGT2B15 Gene

Molecular function for UGT2B15 Gene

GENATLAS Biochemistry: UDP glucuronosyltransferase subfamily 2,liver specific,conjugating bile acid
UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
UniProtKB/Swiss-Prot Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

Enzyme Numbers (IUBMB) for UGT2B15 Gene

Gene Ontology (GO) - Molecular Function for UGT2B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IDA 20056724
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT2B15: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT2B15 Gene

Localization for UGT2B15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B15 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B15 Gene COMPARTMENTS Subcellular localization image for UGT2B15 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
peroxisome 2
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2B15: view

Pathways for UGT2B15 Gene

genes like me logo Genes that share pathways with UGT2B15: view

Interacting Proteins for UGT2B15 Gene

Gene Ontology (GO) - Biological Process for UGT2B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006805 xenobiotic metabolic process TAS 7835232
GO:0008152 metabolic process --
GO:0008202 steroid metabolic process TAS 7835232
GO:0009813 flavonoid biosynthetic process IBA --
genes like me logo Genes that share ontologies with UGT2B15: view

Compounds for UGT2B15 Gene

(85) HMDB Compounds for UGT2B15 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available

(21) Novoseek inferred chemical compound relationships for UGT2B15 Gene

Compound -log(P) Hits PubMed IDs
glucuronide 83.7 1
uridine diphosphate 75.7 3
dihydrotestosterone 73.1 7
uridine 63.6 3
glucuronic acid 61.1 2

(3) PharmGKB related drug/compound annotations for UGT2B15 Gene

Drug/compound Annotation
eltrombopag
oxazepam CA
sipoglitazar CA
genes like me logo Genes that share compounds with UGT2B15: view

Transcripts for UGT2B15 Gene

mRNA/cDNA for UGT2B15 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UGT2B15 Gene

UDP glucuronosyltransferase 2 family, polypeptide B15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B15 Gene

No ASD Table

Relevant External Links for UGT2B15 Gene

GeneLoc Exon Structure for
UGT2B15
ECgene alternative splicing isoforms for
UGT2B15

Expression for UGT2B15 Gene

mRNA expression in normal human tissues for UGT2B15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B15 Gene

This gene is overexpressed in Liver (28.8), Colon - Transverse (11.7), and Small Intestine - Terminal Ileum (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UGT2B15 Gene

SOURCE GeneReport for Unigene cluster for UGT2B15 Gene Hs.150207

mRNA Expression by UniProt/SwissProt for UGT2B15 Gene

P54855-UDB15_HUMAN
Tissue specificity: Expressed in many tissues. Present in liver, prostate and testis.
genes like me logo Genes that share expressions with UGT2B15: view

Orthologs for UGT2B15 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B15 35
  • 99.18 (n)
  • 98.3 (a)
UGT2B15 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt2b38 16
Ugt2b38 36
  • 67 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b37 35
  • 73.55 (n)
  • 65.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10178 37
  • 27 (a)
BEST:GH09393 37
  • 33 (a)
Ugt86Da 37
  • 33 (a)
Dot 37
  • 24 (a)
CG16732 37
  • 24 (a)
CG10168 37
  • 25 (a)
Ugt36Bb 37
  • 28 (a)
Ugt86De 37
  • 26 (a)
CG11289 37
  • 31 (a)
Ugt36Bc 37
  • 30 (a)
CG10170 37
  • 24 (a)
CG5999 37
  • 26 (a)
Ugt86Di 37
  • 34 (a)
Ugt37c1 37
  • 30 (a)
Ugt86Dd 37
  • 30 (a)
Ugt35b 37
  • 31 (a)
CG15661 37
  • 30 (a)
Ugt86Dh 37
  • 25 (a)
Ugt36Ba 37
  • 29 (a)
Ugt37b1 37
  • 27 (a)
BEST:GH06505 37
  • 30 (a)
Ugt86Dc 37
  • 29 (a)
Ugt35a 37
  • 36 (a)
CG5724 37
  • 25 (a)
Ugt37a1 37
  • 30 (a)
CG6475 37
  • 35 (a)
CG17323 37
  • 26 (a)
Ugt86Dg 37
  • 35 (a)
Ugt86Dj 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea T07C5.1a 37
  • 24 (a)
F56B3.7 37
  • 24 (a)
C08F11.8 37
  • 23 (a)
C17G1.3 37
  • 25 (a)
Y37E11AR.5 37
  • 24 (a)
T03D3.1 37
  • 24 (a)
C08B6.1 37
  • 23 (a)
F35H8.6 37
  • 28 (a)
R04B5.9 37
  • 24 (a)
ZC455.3 37
  • 24 (a)
C44H9.1 37
  • 25 (a)
C33A12.6 37
  • 27 (a)
F39G3.1 37
  • 29 (a)
M88.1 37
  • 31 (a)
T19H12.11 37
  • 25 (a)
F01D4.1 37
  • 23 (a)
Species with no ortholog for UGT2B15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B15 Gene

ENSEMBL:
Gene Tree for UGT2B15 (if available)
TreeFam:
Gene Tree for UGT2B15 (if available)

Paralogs for UGT2B15 Gene

genes like me logo Genes that share paralogs with UGT2B15: view

Variants for UGT2B15 Gene

Sequence variations from dbSNP and Humsavar for UGT2B15 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3100 -- 68,646,936(-) TTTAG(C/T)TGGAA utr-variant-3-prime
rs17048 -- 68,662,096(+) GCAAA(C/T)ATAGA intron-variant
rs988560 -- 68,671,560(-) cctgc(A/C)aacag upstream-variant-2KB
rs988562 -- 68,671,060(-) tatgg(C/T)atatg upstream-variant-2KB
rs989075 -- 68,667,503(-) AGGGG(A/T)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B15 Gene

Variant ID Type Subtype PubMed ID
dgv1626e1 CNV Complex 17122850
dgv1628e1 CNV Complex 17122850
dgv5580n71 CNV Loss 21882294
dgv1629e1 CNV Complex 17122850
dgv5581n71 CNV Loss 21882294
nsv879230 CNV Gain 21882294
dgv5582n71 CNV Gain 21882294
dgv5583n71 CNV Gain 21882294
dgv5584n71 CNV Loss 21882294
nsv442910 CNV CNV 18776908
dgv5585n71 CNV Gain 21882294
dgv5586n71 CNV Gain+Loss 21882294
dgv5588n71 CNV Gain+Loss 21882294
dgv5589n71 CNV Loss 21882294
nsv820369 CNV Deletion 20802225
nsv822582 CNV Loss 20364138
dgv951e199 CNV Deletion 23128226
esv1010584 CNV Loss 20482838
nsv10516 CNV Gain 18304495
esv28502 CNV Gain 19812545
esv2727770 CNV Deletion 23290073
esv33605 CNV Loss 17666407
dgv1631e1 CNV Complex 17122850
dgv875n67 CNV Loss 20364138
esv30002 CNV Gain 17803354
esv2421501 CNV Deletion 20811451
esv29960 CNV Gain 18421352
dgv5590n71 CNV Gain 21882294
dgv5591n71 CNV Gain 21882294
nsv514223 CNV Loss 21397061
nsv511249 CNV Loss 21212237
dgv5592n71 CNV Gain 21882294
dgv26n14 CNV Loss 18776910
dgv5593n71 CNV Gain 21882294
dgv5594n71 CNV Loss 21882294
dgv5595n71 CNV Loss 21882294
dgv89n17 CNV Loss 16327808
dgv5596n71 CNV Gain+Loss 21882294
dgv5597n71 CNV Gain 21882294
dgv5598n71 CNV Loss 21882294
nsv879330 CNV Gain 21882294
nsv879332 CNV Gain+Loss 21882294
dgv5599n71 CNV Gain 21882294
dgv877n67 CNV Loss 20364138
nsv436941 CNV Loss 16327808
dgv91n17 CNV Loss 16327808
nsv879339 CNV Loss 21882294
esv2669141 CNV Deletion 23128226
nsv822592 CNV Loss 20364138
dgv5601n71 CNV Gain 21882294
dgv5602n71 CNV Gain 21882294
dgv890e201 CNV Deletion 23290073
nsv879364 CNV Loss 21882294

Relevant External Links for UGT2B15 Gene

HapMap Linkage Disequilibrium report
UGT2B15
Human Gene Mutation Database (HGMD)
UGT2B15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B15 Gene

Disorders for UGT2B15 Gene

(2) University of Copenhagen DISEASES for UGT2B15 Gene

(4) Novoseek inferred disease relationships for UGT2B15 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 48.8 9
breast cancer 16.4 3
tumors 0 3
cancer 0 1

Relevant External Links for UGT2B15

Genetic Association Database (GAD)
UGT2B15
Human Genome Epidemiology (HuGE) Navigator
UGT2B15
genes like me logo Genes that share disorders with UGT2B15: view

No data available for UniProtKB/Swiss-Prot for UGT2B15 Gene

Publications for UGT2B15 Gene

  1. A major genotype in UDP-glucuronosyltransferase 2B15. (PMID: 15618667) Toide K. … Kamataki T. (Drug Metab. Pharmacokinet. 2002) 3 4 23 48
  2. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PMID: 15318931) Sparks R. … McTiernan A. (Breast Cancer Res. 2004) 3 23 48
  3. UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. (PMID: 15044558) Court M.H. … Greenblatt D.J. (J. Pharmacol. Exp. Ther. 2004) 3 23 48
  4. Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer. (PMID: 15126881) Park J. … Pow-Sang J. (J. Urol. 2004) 3 23 48
  5. Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. (PMID: 16513443) Katz D.A. … Kim R.B. (Clin. Pharmacol. Ther. 2006) 3 23 48

Products for UGT2B15 Gene

Sources for UGT2B15 Gene

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