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Aliases for UGT2B11 Gene

Aliases for UGT2B11 Gene

  • UDP Glucuronosyltransferase Family 2 Member B11 2 3 5
  • EC 2.4.1.17 4 61
  • UDP Glycosyltransferase 2 Family, Polypeptide B11 2
  • UDPGT 2B11 4

External Ids for UGT2B11 Gene

Previous GeneCards Identifiers for UGT2B11 Gene

  • GC04M069976
  • GC04M070114
  • GC04M070315
  • GC04M070185
  • GC04M070187
  • GC04M070051
  • GC04M069905
  • GC04M069871
  • GC04M065861
  • GC04M069005

Summaries for UGT2B11 Gene

GeneCards Summary for UGT2B11 Gene

UGT2B11 (UDP Glucuronosyltransferase Family 2 Member B11) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B28.

UniProtKB/Swiss-Prot for UGT2B11 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B11 Gene

Genomics for UGT2B11 Gene

Regulatory Elements for UGT2B11 Gene

Enhancers for UGT2B11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F068946 1.3 FANTOM5 ENCODE 9.8 +266.1 266058 7.8 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 PAF1 SP5 MIER2 REST LOC105377267 UGT2B7 UGT2B28 UGT2A3 UGT2B11 UGT2B15 UGT2B10 LOC101927264
GH04F069308 0.6 ENCODE 8.4 -92.6 -92580 1.7 SMARCE1 MTA2 TAL1 CHAMP1 ARID1B NCOR1 SMARCA4 ID3 TRIM24 UGT2B11 UGT2B7 LOC100422022 PIR39330
GH04F068747 0.4 ENCODE 8 +468.1 468111 2.4 NFE2 MAFK LOC100422026 UGT2B11 UGT2B7 ENSG00000272626 LOC728811
GH04F068731 1.3 FANTOM5 ENCODE 1.8 +482.5 482504 5.9 ATF1 MLX ARID4B ZNF48 YY1 SP5 MIER2 PPARG KAT8 SSRP1 LOC100422026 TMPRSS11E UGT2A3 UGT2B7 ENSG00000272626 UGT2B10 UGT2B11 UGT2B15 LOC728811
GH04F069239 0.8 ENCODE 0.3 -23.4 -23396 1.7 SOX13 TAL1 RARA CHAMP1 TEAD3 FOXK2 NCOR1 TRIM24 HOMEZ MIXL1 LOC105377267 UGT2B28 LOC100533845 UGT2B11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UGT2B11 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2B11 Gene

Chromosome:
4
Start:
69,199,655 bp from pter
End:
69,216,768 bp from pter
Size:
17,114 bases
Orientation:
Minus strand

Genomic View for UGT2B11 Gene

Genes around UGT2B11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B11 Gene

Proteins for UGT2B11 Gene

  • Protein details for UGT2B11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75310-UDB11_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B11
    Protein Accession:
    O75310
    Secondary Accessions:
    • Q3KNV9

    Protein attributes for UGT2B11 Gene

    Size:
    529 amino acids
    Molecular mass:
    61038 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UGT2B11 Gene

Selected DME Specific Peptides for UGT2B11 Gene

O75310:
  • DLLNALK
  • GHPKTRAFITH
  • AFITHGG
  • FPHPFLPN
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • FVQSSGE
  • FWLYFSQ
  • CKDVVSNK
  • AAHDLTW
  • KPLDRAVFWIE
  • KLQESRFD
  • WMNMKTIL
  • YEAIYHG
  • RGHEVTVL
  • MTFMERV
  • CGKVLVW
  • QYHSLDV
  • TMSSTDL
  • DVIGFLL
  • KKWDQFYSEVLGRPTTL
  • WIPQNDLLG
  • FLLACVA
  • NALKTVINDP
  • IPQKVLW
  • NTRLYKW
  • DQPDNIAHMK
  • THGGANG
  • ERVKNMIY

Post-translational modifications for UGT2B11 Gene

  • Glycosylation at Asn 315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B11 Gene

Domains & Families for UGT2B11 Gene

Gene Families for UGT2B11 Gene

Protein Domains for UGT2B11 Gene

Suggested Antigen Peptide Sequences for UGT2B11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75310

UniProtKB/Swiss-Prot:

UDB11_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B11: view

Function for UGT2B11 Gene

Molecular function for UGT2B11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Enzyme Numbers (IUBMB) for UGT2B11 Gene

Gene Ontology (GO) - Molecular Function for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IEA,IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B11: view
genes like me logo Genes that share phenotypes with UGT2B11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT2B11 Gene

Localization for UGT2B11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B11 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2B11 gene
Compartment Confidence
endoplasmic reticulum 4
peroxisome 3
golgi apparatus 3
plasma membrane 1
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2B11: view

Pathways & Interactions for UGT2B11 Gene

genes like me logo Genes that share pathways with UGT2B11: view

Pathways by source for UGT2B11 Gene

Gene Ontology (GO) - Biological Process for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS 8333863
GO:0008152 metabolic process IEA --
GO:0008210 estrogen metabolic process TAS 8333863
GO:0009813 flavonoid biosynthetic process IBA --
GO:0052696 flavonoid glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT2B11: view

No data available for SIGNOR curated interactions for UGT2B11 Gene

Drugs & Compounds for UGT2B11 Gene

(14) Drugs for UGT2B11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 74
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1283
Estriol Approved, Vet_approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 21
Morphine Approved, Investigational Pharma Full agonist, Agonist 960

(83) Additional Compounds for UGT2B11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT2B11: view

Transcripts for UGT2B11 Gene

mRNA/cDNA for UGT2B11 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UGT2B11 Gene

UDP glucuronosyltransferase 2 family, polypeptide B11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B11 Gene

No ASD Table

Relevant External Links for UGT2B11 Gene

GeneLoc Exon Structure for
UGT2B11
ECgene alternative splicing isoforms for
UGT2B11

Expression for UGT2B11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT2B11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B11 Gene

This gene is overexpressed in Liver (x21.4), Breast - Mammary Tissue (x10.4), and Kidney - Cortex (x6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UGT2B11 Gene



NURSA nuclear receptor signaling pathways regulating expression of UGT2B11 Gene:

UGT2B11

SOURCE GeneReport for Unigene cluster for UGT2B11 Gene:

Hs.339811

mRNA Expression by UniProt/SwissProt for UGT2B11 Gene:

O75310-UDB11_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with UGT2B11: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for UGT2B11 Gene

Orthologs for UGT2B11 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B11 34
  • 97.42 (n)
-- 35
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 81 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia RGD1559459 34
  • 74.86 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 70 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ugt2b37 35
  • 63 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6475 36 34
  • 47.38 (n)
Ugt86Da 36
  • 35 (a)
Ugt86Dg 36
  • 34 (a)
CG11289 36
  • 32 (a)
Ugt35b 36
  • 32 (a)
Ugt37a1 36
  • 31 (a)
Ugt86Dd 36
  • 31 (a)
Ugt35a 36
  • 30 (a)
CG15661 36
  • 29 (a)
Ugt36Bb 36
  • 28 (a)
Ugt36Bc 36
  • 27 (a)
CG5999 36
  • 26 (a)
Ugt37b1 36
  • 26 (a)
Ugt86Dj 36
  • 26 (a)
CG10170 36
  • 25 (a)
CG10168 36
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea M88.1 36
  • 29 (a)
F39G3.1 36
  • 28 (a)
F35H8.6 36
  • 27 (a)
C18C4.3 36
  • 26 (a)
C03A7.11 36
  • 25 (a)
C08B6.1 36
  • 25 (a)
C44H9.1 36
  • 25 (a)
F56B3.7 36
  • 25 (a)
T03D3.1 36
  • 25 (a)
Y37E11AR.5 36
  • 25 (a)
R04B5.9 36
  • 24 (a)
T19H12.11 36
  • 23 (a)
Species where no ortholog for UGT2B11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B11 Gene

ENSEMBL:
Gene Tree for UGT2B11 (if available)
TreeFam:
Gene Tree for UGT2B11 (if available)

Paralogs for UGT2B11 Gene

Variants for UGT2B11 Gene

Sequence variations from dbSNP and Humsavar for UGT2B11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10007579 -- 69,214,990(+) ACCTA(C/T)TTTAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs10007587 -- 69,215,010(+) AAGAA(C/T)AGTGG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs10012181 -- 69,215,036(+) TGCAG(A/G)GCCCT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111248151 -- 69,222,013(+) ACAAG(C/T)CCTAC intron-variant
rs111299850 -- 69,219,488(+) AGTTT(-/T)ATGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B11 Gene

Variant ID Type Subtype PubMed ID
nsv999654 CNV gain 25217958
nsv980214 CNV duplication 23825009
nsv594584 CNV loss 21841781
nsv519544 CNV gain+loss 19592680
nsv482088 CNV gain 20164927
nsv1130819 CNV deletion 24896259
nsv1067929 OTHER inversion 25765185
nsv10524 CNV gain+loss 18304495
nsv1013269 CNV gain 25217958
nsv1002926 CNV loss 25217958
nsv1002753 CNV loss 25217958
esv3893952 CNV loss 25118596
esv3893950 CNV gain 25118596
esv3600894 CNV gain 21293372
esv28328 CNV gain+loss 19812545
esv2759258 CNV gain+loss 17122850
esv2727780 CNV deletion 23290073
esv2727775 CNV deletion 23290073
esv2671471 CNV deletion 23128226
esv2670036 CNV deletion 23128226
dgv844e201 CNV deletion 23290073
dgv17n31 CNV gain 19718026

Variation tolerance for UGT2B11 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2B11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2B11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B11 Gene

Disorders for UGT2B11 Gene

Relevant External Links for UGT2B11

Genetic Association Database (GAD)
UGT2B11
Human Genome Epidemiology (HuGE) Navigator
UGT2B11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2B11

No disorders were found for UGT2B11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2B11 Gene

Publications for UGT2B11 Gene

  1. Isolation and characterization of a human orphan UDP- glucuronosyltransferase, UGT2B11. (PMID: 9675083) Beaulieu M. … Belanger A. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  2. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PMID: 20214802) Li J. … Hall P. (Breast Cancer Res. 2010) 3 46 64
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64
  4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for UGT2B11 Gene

Sources for UGT2B11 Gene

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