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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT2B11 Gene

protein-coding   GIFtS: 55
GCID: GC04M070051

UDP glucuronosyltransferase 2 family, polypeptide B11

(Previous names: UDP glycosyltransferase 2 family, polypeptide B11 )
 Explore 5 diseases affiliated with
UGT2B11 via our new
 Human Malady Compendium 
Biological research products
for UGT2B11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B111 2
UDP Glycosyltransferase 2 Family, Polypeptide B111 2
UDPGT 2B112 3
EC 2.4.1.173 8
UDP Glycosyltransferase 2 Family Protein2
UDP-Glucuronosyltransferase 2B112

External Ids:    HGNC: 125451   Entrez Gene: 107202   Ensembl: ENSG000002137597   OMIM: 6030645   UniProtKB: O753103   

Export aliases for UGT2B11 gene to outside databases

Previous GC identifers: GC04M069976 GC04M070114 GC04M070315 GC04M070185 GC04M070187 GC04M069905 GC04M069871 GC04M065861


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UDB11_HUMAN, O75310
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT2B11 gene promoter:
         HOXA9   HOXA9B   FOXD1   Nkx2-5   C/EBPalpha   FAC1   FOXO1a   Meis-1a   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGT2B11 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGT2B11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2B11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.3

UGT2B11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B11 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M070051:  view genomic region     (about GC identifiers)

Start:
70,065,669 bp from pter      End:
70,080,449 bp from pter
Size:
14,781 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UDB11_HUMAN, O75310 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2B11 precursor  
Size: 529 amino acids; 61038 Da
Subcellular location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane;
Single-pass membrane protein (Potential)
Secondary accessions: Q3KNV9

Explore the universe of human proteins at neXtProt for UGT2B11: NX_O75310

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75310

  • 4/30 DME Specific Peptides for UGT2B11 (O75310) (see all 30)
     DLLNALK  AFITHGG  MTFMERV  CGKVLVW 

    UGT2B11 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_001064.1  
    ENSEMBL proteins: 
     ENSP00000387683  
    Reactome Protein details: O75310
    Human Recombinant Protein Products: 
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    Uscn Proteins for UGT2B11

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--


    UGT2B11 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UGT2B11 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry O75310

    ProtoNet protein and cluster: O75310

    1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UDB11_HUMAN, O75310
    Similarity: Belongs to the UDP-glycosyltransferase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: UDB11_HUMAN, O75310
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
    and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

    Enzyme Number (IUBMB): EC 2.4.1.171 2

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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UGT2B11

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015020glucuronosyltransferase activity IEA--


    UGT2B11 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    Glucuronidation1.00
    Porphyrin and chlorophyll metabolism0.38
    Glucuronidation0.67
    Other types of O-glycan biosynthesis0.36
    Starch and sucrose metabolism0.42
    Drug metabolism - other enzymes0.32
    2Drug metabolism - cytochrome P450
    Drug metabolism - cytochrome P4501.00
    Retinol metabolism0.40
    Metabolism of xenobiotics by cytochrome P4500.73
    3Biological oxidations
    Biological oxidations1.00
    metapathway biotransformation0.41
    Phase II conjugation0.52
    4Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    5Pentose and glucuronate interconversions
    Pentose and glucuronate interconversions1.00
    Ascorbate and aldarate metabolism0.62

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for UGT2B11
        Estradiol metabolism


    1 GeneGo (Thomson Reuters) Pathway for UGT2B11
        Estradiol metabolism

    2 BioSystems Pathways for UGT2B11 
        Glucuronidation
    metapathway biotransformation

    4        Reactome Pathways for UGT2B11
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation


    5/11         Kegg Pathways  (Kegg details for UGT2B11) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Other types of O-glycan biosynthesis


    UGT2B11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT2B11

    1 Interacting protein for UGT2B11 (O753103) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3C2AO004433I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS8333863
    GO:0008210estrogen metabolic process TAS8333863


    UGT2B11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT2B11

    10/85 HMDB Compounds for UGT2B11 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----
    Search CenterWatch for drugs/clinical trials and news about UGT2B11 / UDB11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGT2B11 gene: 
    NM_001073.1  

    Unigene Cluster for UGT2B11:

    UDP glucuronosyltransferase 2 family, polypeptide B11
    Hs.339811  [show with all ESTs]
    Unigene Representative Sequence: AF016492
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446444(uc003heh.3) ENST00000513315

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    Additional cDNA sequence: 

    AF016492.1 BC069441.1 BC107059.2 BC107060.2 

    4 DOTS entries:

    DT.121232122  DT.91817318  DT.100717704  DT.95255211 

    9 AceView cDNA sequences:

    NM_001073 BX485008 AF016492 BX485009 BC069441 BG215131 BG195984 N70316 
    BG214065 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT2B11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTCACCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    UGT2B11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Embryoid bodies (Two-step protocol fo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for UGT2B11

    SOURCE GeneReport for Unigene cluster: Hs.339811

    UniProtKB/Swiss-Prot: UDB11_HUMAN, O75310
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UGT2B11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT2B11 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves F1NMB3_CHICK6
    Uncharacterized protein
    56(a)
    1 → many
    4(53288491-53295396)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    55(a)
    55(a)
    many ↔ many
    many ↔ many
    6(58564243-58578541)
    6(58629882-58649612)
    zebrafish
    (Danio rerio)
    Actinopterygii BX571679.16
    ugt2a46
    (see all 15)
    --
    UDP glucuronosyltransferase 2 family, polypeptide ...
    (see all 15)
    62(a)
    51(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    5(9986135-9988976)
    5(72956618-72977951)


    ENSEMBL Gene Tree for UGT2B11 (if available)
    TreeFam Gene Tree for UGT2B11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT2B11 gene
    UGT2A22  UGT1A82  UGT1A72  UGT3A12  UGT2B72  UGT1A32  UGT1A12  UGT1A52  
    UGT3A22  UGT2B102  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  UGT2B172  
    UGT2A32  UGT2B282  UGT1A92  UGT1A42  
    18/26 SIMAP similar genes for UGT2B11 using alignment to 2 protein entries:     UDB11_HUMAN (see all proteins) (see all similar genes):
    UGT2B28    UGT2B4    UGT2B7    UGT2B15    UGT2B17    UGT2B10
    UGT2A3    UGT2A1    UGT1A9S    BILIQTL1    UGT1A8S    UGT1A5
    UGT1A4    UGT1A6    UGT1A8    UGT1A1    UGT1A4S    UGT1A7

    UGT2B11 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for UGT2B11
    PGOHUM00000245941 PGOHUM00000245942 PGOHUM00000250781


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for UGT2B11
         4 CNVs: 2528 3499 68743 31180
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT2B11
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT2B11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UGT2B11 for disorders           About GeneDecksing

    OMIM gene information: 603064    OMIM disorders: --

    5 diseases for UGT2B11:    About MalaCards
    gilbert syndrome    hearing loss    fascioliasis    breast cancer
    cholesterol

    3 diseases from the University of Copenhagen DISEASES database for UGT2B11:
    Gilbert syndrome     Prostate cancer     Fascioliasis
    Human Genome Epidemiology (HuGE) Navigator: UGT2B11 (14 documents)

    Export disorders for UGT2B11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT2B11 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with UGT2B11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a human orphan UDP- glucuronosyltransferase, UGT2B11. (PubMed id 9675083)1, 2, 3 Beaulieu M.... Belanger A. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Quantitative analysis of UGT2B28 mRNA expression by r eal-time RT-PCR and application to human tissue distribution study. (PubMed id 21679149)1 Ohno S. and Nakajin S. (2011)
    4. Genetic variation in the estrogen metabolic pathway a nd mammographic density as an intermediate phenotype of breast cancer. (PubMed id 20214802)1 Li J....Hall P. (2010)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)
    6. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1 Ross C.J....Hayden M.R. (2009)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Formation of beta-glucuronides and of beta-galacturon ides of various retinoids catalyzed by induced and noninduced microsomal UDP-gl ucuronosyltransferases of rat liver. (PubMed id 8600986)6 Genchi G....Olson J.A. (1996)
    9. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. (PubMed id 8333863)1 Jin C.-J.... McKenzie P.I. (1993)
    10. The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases. (PubMed id 8269638)9 Jin C.J....Mackenzie P.I. (1993)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10720 HGNC: 12545 AceView: UGT2B11 Ensembl:ENSG00000213759 euGenes: HUgn10720
    ECgene: UGT2B11 Kegg: 10720 H-InvDB: UGT2B11

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for UGT2B11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UGT2B11 gene:
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