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Aliases for UGT2B11 Gene

Aliases for UGT2B11 Gene

  • UDP Glucuronosyltransferase 2 Family, Polypeptide B11 2 3
  • EC 2.4.1.17 4 63
  • UDP Glycosyltransferase 2 Family, Polypeptide B11 2
  • UDPGT 2B11 4

External Ids for UGT2B11 Gene

Previous GeneCards Identifiers for UGT2B11 Gene

  • GC04M069976
  • GC04M070114
  • GC04M070315
  • GC04M070185
  • GC04M070187
  • GC04M070051
  • GC04M069905
  • GC04M069871
  • GC04M065861

Summaries for UGT2B11 Gene

GeneCards Summary for UGT2B11 Gene

UGT2B11 (UDP Glucuronosyltransferase 2 Family, Polypeptide B11) is a Protein Coding gene. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2B11 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B11 Gene

Genomics for UGT2B11 Gene

Regulatory Elements for UGT2B11 Gene

Genomic Location for UGT2B11 Gene

Chromosome:
4
Start:
69,004,618 bp from pter
End:
69,216,768 bp from pter
Size:
212,151 bases
Orientation:
Minus strand

Genomic View for UGT2B11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT2B11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B11 Gene

Proteins for UGT2B11 Gene

  • Protein details for UGT2B11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75310-UDB11_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B11
    Protein Accession:
    O75310
    Secondary Accessions:
    • Q3KNV9

    Protein attributes for UGT2B11 Gene

    Size:
    529 amino acids
    Molecular mass:
    61038 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UGT2B11 Gene

Proteomics data for UGT2B11 Gene at MOPED

Post-translational modifications for UGT2B11 Gene

  • Glycosylation at Asn 315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT2B11 Gene

Gene Families for UGT2B11 Gene

Protein Domains for UGT2B11 Gene

Suggested Antigen Peptide Sequences for UGT2B11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75310

UniProtKB/Swiss-Prot:

UDB11_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B11: view

Function for UGT2B11 Gene

Molecular function for UGT2B11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

Enzyme Numbers (IUBMB) for UGT2B11 Gene

Gene Ontology (GO) - Molecular Function for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IBA --
GO:0016758 transferase activity, transferring hexosyl groups --
genes like me logo Genes that share ontologies with UGT2B11: view

Phenotypes for UGT2B11 Gene

genes like me logo Genes that share phenotypes with UGT2B11: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UGT2B11

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT2B11 Gene

Localization for UGT2B11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B11 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B11 Gene COMPARTMENTS Subcellular localization image for UGT2B11 gene
Compartment Confidence
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2B11: view

Pathways & Interactions for UGT2B11 Gene

genes like me logo Genes that share pathways with UGT2B11: view

Pathways by source for UGT2B11 Gene

Interacting Proteins for UGT2B11 Gene

Gene Ontology (GO) - Biological Process for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS 8333863
GO:0008152 metabolic process --
GO:0008210 estrogen metabolic process TAS 8333863
GO:0009813 flavonoid biosynthetic process IBA --
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with UGT2B11: view

No data available for SIGNOR curated interactions for UGT2B11 Gene

Drugs & Compounds for UGT2B11 Gene

(13) Drugs for UGT2B11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 62
Estradiol Approved, Investigational Pharma Sex hormone 1057
Estriol Approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 18
Morphine Approved, Investigational Pharma Partial agonist, Agonist 805

(84) Additional Compounds for UGT2B11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT2B11: view

Transcripts for UGT2B11 Gene

mRNA/cDNA for UGT2B11 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UGT2B11 Gene

UDP glucuronosyltransferase 2 family, polypeptide B11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UGT2B11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B11 Gene

No ASD Table

Relevant External Links for UGT2B11 Gene

GeneLoc Exon Structure for
UGT2B11
ECgene alternative splicing isoforms for
UGT2B11

Expression for UGT2B11 Gene

mRNA expression in normal human tissues for UGT2B11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B11 Gene

This gene is overexpressed in Liver (x21.4), Breast - Mammary Tissue (x10.4), and Kidney - Cortex (x6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UGT2B11 Gene



SOURCE GeneReport for Unigene cluster for UGT2B11 Gene Hs.339811

mRNA Expression by UniProt/SwissProt for UGT2B11 Gene

O75310-UDB11_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expression patterns with UGT2B11: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for UGT2B11 Gene

Orthologs for UGT2B11 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B11 35
  • 97.42 (n)
  • 95.65 (a)
-- 36
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1559459 35
  • 74.86 (n)
  • 66.73 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ugt2b37 36
  • 63 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10168 37
  • 24 (a)
CG10170 37
  • 25 (a)
CG11289 37
  • 32 (a)
CG15661 37
  • 29 (a)
CG5999 37
  • 26 (a)
CG6475 37
  • 32 (a)
Ugt35a 37
  • 30 (a)
Ugt35b 37
  • 32 (a)
Ugt36Bb 37
  • 28 (a)
Ugt36Bc 37
  • 27 (a)
Ugt37a1 37
  • 31 (a)
Ugt37b1 37
  • 26 (a)
Ugt86Da 37
  • 35 (a)
Ugt86Dd 37
  • 31 (a)
Ugt86Dg 37
  • 34 (a)
Ugt86Dj 37
  • 26 (a)
CG6475 35
  • 47.38 (n)
  • 32.64 (a)
worm
(Caenorhabditis elegans)
Secernentea C03A7.11 37
  • 25 (a)
C08B6.1 37
  • 25 (a)
C18C4.3 37
  • 26 (a)
C44H9.1 37
  • 25 (a)
F35H8.6 37
  • 27 (a)
F39G3.1 37
  • 28 (a)
F56B3.7 37
  • 25 (a)
M88.1 37
  • 29 (a)
R04B5.9 37
  • 24 (a)
T03D3.1 37
  • 25 (a)
T19H12.11 37
  • 23 (a)
Y37E11AR.5 37
  • 25 (a)
Species with no ortholog for UGT2B11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B11 Gene

ENSEMBL:
Gene Tree for UGT2B11 (if available)
TreeFam:
Gene Tree for UGT2B11 (if available)

Paralogs for UGT2B11 Gene

Pseudogenes.org Pseudogenes for UGT2B11 Gene

genes like me logo Genes that share paralogs with UGT2B11: view

Variants for UGT2B11 Gene

Structural Variations from Database of Genomic Variants (DGV) for UGT2B11 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
essv17788 CNV CNV 17122850
esv2727775 CNV Deletion 23290073
dgv1634e1 CNV Complex 17122850
dgv1635e1 CNV Complex 17122850
dgv1636e1 CNV Complex 17122850
dgv5608n71 CNV Loss 21882294
dgv891e201 CNV Deletion 23290073
nsv879384 CNV Loss 21882294
nsv519544 CNV Gain+Loss 19592680
dgv5609n71 CNV Gain 21882294
dgv5610n71 CNV Loss 21882294
dgv5611n71 CNV Gain 21882294
esv28328 CNV Gain+Loss 19812545
dgv1637e1 CNV Complex 17122850
nsv10524 CNV Gain+Loss 18304495
esv2670036 CNV Deletion 23128226
dgv17n31 CNV Duplication 19718026
essv5980 CNV CNV 17122850
nsv879389 CNV Gain+Loss 21882294
nsv879390 CNV Gain+Loss 21882294
dgv5612n71 CNV Gain 21882294
nsv879395 CNV Loss 21882294
esv2727780 CNV Deletion 23290073
esv2671471 CNV Deletion 23128226
nsv482088 CNV Gain 20164927
nsv879400 CNV Gain 21882294

Variation tolerance for UGT2B11 Gene

Residual Variation Intolerance Score: 96.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2B11 Gene

HapMap Linkage Disequilibrium report
UGT2B11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for UGT2B11 Gene

Disorders for UGT2B11 Gene

Relevant External Links for UGT2B11

Genetic Association Database (GAD)
UGT2B11
Human Genome Epidemiology (HuGE) Navigator
UGT2B11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2B11
genes like me logo Genes that share disorders with UGT2B11: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2B11 Gene

Publications for UGT2B11 Gene

  1. Isolation and characterization of a human orphan UDP- glucuronosyltransferase, UGT2B11. (PMID: 9675083) Beaulieu M. … Belanger A. (Biochem. Biophys. Res. Commun. 1998) 2 67
  2. The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases. (PMID: 8269638) Jin C.J. … Mackenzie P.I. (Carcinogenesis 1993) 23 67
  3. Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study. (PMID: 21679149) Ohno S. … Nakajin S. (Drug Metab Lett 2011) 67
  4. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PMID: 20214802) Li J. … Hall P. (Breast Cancer Res. 2010) 67
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 67

Products for UGT2B11 Gene

Sources for UGT2B11 Gene

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