Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UGT2B10 Gene

protein-coding   GIFtS: 59
GCID: GC04P069730

UDP Glucuronosyltransferase 2 Family, Polypeptide B10

(Previous names: UDP glycosyltransferase 2 family, polypeptide B10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide B101 2
UDPGT 2B102 3
EC 2.4.1.173 8
UDP Glycosyltransferase 2 Family, Polypeptide B101
UDPGT2B102
UDP-Glucuronosyltransferase 2B102

External Ids:    HGNC: 125441   Entrez Gene: 73652   Ensembl: ENSG000001091817   OMIM: 6000705   UniProtKB: P365373   

Export aliases for UGT2B10 gene to outside databases

Previous GC identifers: GC04P069592 GC04P069931 GC04P069997 GC04P069862 GC04P065477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for UGT2B10 Gene:
UGT2B10 (UDP glucuronosyltransferase 2 family, polypeptide B10) is a protein-coding gene. Diseases associated with UGT2B10 include gilbert syndrome, and labyrinthitis. GO annotations related to this gene include glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UDB10_HUMAN, P36537
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds

Gene Wiki entry for UGT2B10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  NT_167250.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UGT2B10 gene promoter:
         C/EBPbeta   AML1a   FOXD1   FOXO1a   Meis-1a   Pax-4a   FOXO1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGT2B10 promoter sequence
   Search Chromatin IP Primers for UGT2B10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT2B10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.3

UGT2B10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2B10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P069730:  view genomic region     (about GC identifiers)

Start:
69,681,711 bp from pter      End:
69,697,741 bp from pter
Size:
16,031 bases      Orientation:
plus strand

2 alternative locations:
Chr4+,NT_167250 393,964-409,992      Chr4+ 69,564,040-69,580,068     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UDB10_HUMAN, P36537 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2B10 precursor  
Size: 528 amino acids; 60774 Da
Secondary accessions: A8K9M3 Q14CR8

Explore the universe of human proteins at neXtProt for UGT2B10: NX_P36537

Explore proteomics data for UGT2B10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn66, Asn314, Asn481
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGT2B10 (P36537) (see all 33)
     DLLNALK  AFITHGG  LLGHPKT  FVQSSGE 


    See UGT2B10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001066.1  NP_001138239.1  NP_001277020.1  

    ENSEMBL proteins: 
     ENSP00000265403   ENSP00000413420  
    Reactome Protein details: P36537

    UGT2B10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for UGT2B10
    OriGene Protein Over-expression Lysate for UGT2B10
    OriGene MassSpec for UGT2B10
    OriGene Custom Protein Services for UGT2B10
    GenScript Custom Purified and Recombinant Proteins Services for UGT2B10
    Novus Biologicals UGT2B10 Protein
    Novus Biologicals UGT2B10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UGT2B10

    UGT2B10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UGT2B10
    Novus Biologicals UGT2B10 Antibodies
    Abcam antibodies for UGT2B10
    Cloud-Clone Corp. Antibodies for UGT2B10
    Search ThermoFisher Antibodies for UGT2B10
    LSBio Antibodies in human, mouse, rat for UGT2B10

    UGT2B10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UGT2B10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UGT2B10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UGT2B10
    Cloud-Clone Corp. CLIAs for UGT2B10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P36537

    ProtoNet protein and cluster: P36537

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UDB10_HUMAN, P36537
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT2B10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UDB10_HUMAN, P36537
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015020glucuronosyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    UGT2B10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT2B10:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT2B10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGT2B10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGT2B10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGT2B10

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UGT2B10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UGT2B10
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UGT2B10
    Predesigned siRNA for gene silencing in human, mouse, rat UGT2B10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UGT2B10

    Clone
    Products:
         
    OriGene clones in human, mouse for UGT2B10 (see all 12)
    OriGene ORF clones in mouse, rat for UGT2B10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UGT2B10 (NM_001075)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT2B10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT2B10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UGT2B10
    Browse ESI BIO Cell Lines and PureStem Progenitors for UGT2B10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2B10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UDB10_HUMAN, P36537: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum
    membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    peroxisome3
    cytoskeleton1
    cytosol1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    UGT2B10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UGT2B10 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    4Biological oxidations
    Biological oxidations0.56
    Glucuronidation0.00
    Phase II conjugation0.56
    5Metabolism of porphyrins
    Porphyrin and chlorophyll metabolism0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for UGT2B10
        Glucuronidation

    1 Reactome Pathway for UGT2B10
        Glucuronidation

    1 PharmGKB Pathway for UGT2B10
        Nicotine Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for UGT2B10) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT2B10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UGT2B10: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UGT2B10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT2B10 (ENSP000002654034) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH6ENSP000003783594STRING: ENSP00000378359
    ADH7ENSP000002096654STRING: ENSP00000209665
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    AKR1D1ENSP000002423754STRING: ENSP00000242375
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006629lipid metabolic process TAS8333863
    GO:0008152metabolic process ----
    GO:0030259lipid glycosylation ----

    UGT2B10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT2B10 (UDB10)

    Selected HMDB Compounds for UGT2B10 (see all 84)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----
    17-beta-estradiol glucuronide ----

    1 Novoseek inferred chemical compound relationship for UGT2B10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 17.9 2 11159850 (1)

    1 PharmGKB related drug/compound annotation for UGT2B10 gene    About this table
    Drug/compound PharmGKB Annotation
    nicotineCA  



    UGT2B10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UGT2B10 gene (3 alternative transcripts): 
    NM_001075.5  NM_001144767.2  NM_001290091.1  

    Unigene Cluster for UGT2B10:

    UDP glucuronosyltransferase 2 family, polypeptide B10
    Hs.201634  [show with all ESTs]
    Unigene Representative Sequence: NM_001075
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265403(uc003hee.3 uc011cam.2) ENST00000458688
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UGT2B10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UGT2B10
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UGT2B10
    Predesigned siRNA for gene silencing in human, mouse, rat UGT2B10
    Clone
    Products:
         
    OriGene clones in human, mouse for UGT2B10 (see all 12)
    OriGene ORF clones in mouse, rat for UGT2B10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UGT2B10 (NM_001075)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT2B10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT2B10
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UGT2B10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGT2B10
      QuantiTect SYBR Green Assays in human, mouse, rat UGT2B10
      QuantiFast Probe-based Assays in human, mouse, rat UGT2B10

    Additional mRNA sequence: 

    AK222839.1 AK222872.1 AK292738.1 AK298432.1 BC113649.1 

    4 DOTS entries:

    DT.100783300  DT.100814505  DT.434931  DT.91741715 

    Selected AceView cDNA sequences (see all 35):

    CB164598 T57898 NM_001075 H69250 T46839 CD013994 CD013995 BV201798 
    CB161428 BG201991 BV199400 BV199399 BV199398 BV172697 CB113377 BG189133 
    AI688814 AV696157 CD610478 T57980 AI032906 BG212458 R00510 N78136 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UGT2B10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGATTTCAA
    UGT2B10 Expression
    About this image


    UGT2B10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Lung (Respiratory System)
             Trachea
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Brain (Nervous System)
             Medulla Oblongata
    UGT2B10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT2B10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.201634
        Pathway & Disease-focused RT2 Profiler PCR Array including UGT2B10: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UGT2B10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGT2B10
    QuantiTect SYBR Green Assays in human, mouse, rat UGT2B10
    QuantiFast Probe-based Assays in human, mouse, rat UGT2B10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2B10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for UGT2B10 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt2b341 , 5 UDP glucuronosyltransferase 2 family, polypeptide B341, 5 76.9(n)1
    68.52(a)1
      5 (43.56 cM)5
    1007271  NM_153598.21  NP_705826.11 
     868897675 


    ENSEMBL Gene Tree for UGT2B10 (if available)
    TreeFam Gene Tree for UGT2B10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UGT2B10 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  
    UGT3A22  UGT1A52  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    Selected SIMAP similar genes for UGT2B10 using alignment to 2 protein entries:     UDB10_HUMAN (see all proteins) (see all similar genes):
    UGT2B11    UGT2B28    UGT2B7    UGT2B4    UGT2B17    UGT2A3
    UGT2B15    UGT1A3S    UGT1A9S    UGT2A1    UGT8    UGT2A2
    UGT1A5    UGT1A8S    UGT1A6    BILIQTL1    UGT1A7    UGT1A8

    UGT2B10 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for UGT2B10 (see all 7)
    PGOHUM00000248150 PGOHUM00000259898 PGOHUM00000259900 PGOHUM00000259901 PGOHUM00000259902


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UGT2B10 (see all 606)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs677412311,2
    C--65476718(+) TGATA-/AATG  
            
    AATGA
    2 -- us2k10--------
    rs667015881,2
    C--69576424(+) TTTTGT/-TTTCT 2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1132422321,2
    C--69576442(+) ATGCTA/GACAGT 2 -- us2k10--------
    rs1843621041,2
    --69576461(+) AGCTCC/TGAGTC 2 -- us2k10--------
    rs1896883091,2
    C--69576575(+) GTCACC/TTTCAG 2 -- us2k10--------
    rs1502409671,2
    --69576645(+) TTACTC/GAGAAT 2 -- us2k10--------
    rs1379498991,2
    C--69576650(+) GAGAAG/TGAACT 2 -- us2k10--------
    rs1927339611,2
    --69576768(+) GATACC/TGTTCA 2 -- us2k10--------
    rs1844233101,2
    --69576895(+) TTAATA/CTGTTA 2 -- us2k10--------
    rs1424511241,2
    C--69576897(+) AATCTA/GTTAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UGT2B10 (69681711 - 69697741 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGT2B10 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727775CNV Deletion23290073
    esv2672025CNV Deletion23128226
    esv2660681CNV Deletion23128226
    esv2421961CNV Duplication20811451
    nsv879379CNV Loss21882294
    nsv829961CNV Loss17160897
    nsv461547CNV Loss19166990
    nsv10521CNV Loss18304495
    dgv5607n71CNV Loss21882294
    esv21679CNV Gain19812545

    Human Gene Mutation Database (HGMD): UGT2B10
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing UGT2B10
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT2B10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600070    OMIM disorders: --

    5 diseases for UGT2B10:    
    About MalaCards
    gilbert syndrome    labyrinthitis    prostate cancer    hepatitis
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for UGT2B10:
    Gilbert syndrome     Prostate cancer

    UGT2B10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UGT2B10
    Human Genome Epidemiology (HuGE) Navigator: UGT2B10 (3 documents)

    Export disorders for UGT2B10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UGT2B10 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with UGT2B10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. (PubMed id 8333863)1, 2, 3 Jin C.-J.... McKenzie P.I. (Biochem. Biophys. Res. Commun. 1993)
    2. Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. (PubMed id 18300939)1, 4, 9 Chen G....Lazarus P. (Pharmacogenet. Genomics 2008)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. (PubMed id 17576790)1, 9 Kaivosaari S....Finel M. (Mol. Pharmacol. 2007)
    6. Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. (PubMed id 10024527)1, 9 Strassburg C.P....Tukey R.H. (Biochem. J. 1999)
    7. Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4. (PubMed id 23611809)1 Kato Y....Nakajima M. (Drug Metab. Dispos. 2013)
    8. Glucuronidation of trans-3'-hydroxycotinine by UGT2B17 and UGT2B10. (PubMed id 22228205)1 Chen G....Lazarus P. (Pharmacogenet. Genomics 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms. (PubMed id 20876810)1 Chen G....Lazarus P. (Cancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7365 HGNC: 12544 AceView: UGT2B10 Ensembl:ENSG00000109181 euGenes: HUgn7365
    ECgene: UGT2B10 Kegg: 7365 H-InvDB: UGT2B10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UGT2B10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UGT2B10 gene:
    Search GeneIP for patents involving UGT2B10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UGT2B10  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UGT2B10  
     OriGene MassSpec something-or-other for UGT2B10   OriGene clones in human, mouse for UGT2B10  
     OriGene qSTAR qPCR primer pairs in human, mouse for UGT2B10   OriGene Purified Protein for UGT2B10  
     OriGene ORF clones in mouse, rat for UGT2B10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UGT2B10   OriGene Custom Protein Services for UGT2B10  

     
     
     Block miRNA regulation of human, mouse, rat UGT2B10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UGT2B10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT2B10 Predesigned siRNA for gene silencing in human, mouse, rat UGT2B10
     QuantiFast Probe-based Assays in human, mouse, rat UGT2B10 QuantiTect SYBR Green Assays in human, mouse, rat UGT2B10
     PCR Arrays including human, mouse, rat UGT2B10 Search Chromatin IP Primers for UGT2B10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGT2B10  GeneGlobe Interaction Network for UGT2B10
     Regulatory tfbs in UGT2B10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UGT2B10 GenScript cDNA clones with any tag delivered in your preferred vector for UGT2B10
     GenScript Custom Assay Services for UGT2B10 GenScript Custom overexpressing Cell Line Services for UGT2B10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UGT2B10 (UDB10)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UGT2B10 antibodies
     UGT2B10 proteins
     UGT2B10 lysates
     Antibodies for UGT2B10
     See all of Abcam's Antibodies, Kits and Proteins for UGT2B10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UGT2B10
     Antibodies for UGT2B10
     ELISAs for UGT2B10
     CLIAs for UGT2B10



     Browse ESI BIO Cell Lines and PureStem Progenitors for UGT2B10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2B10
     Browse SwitchGear 3'UTR luciferase reporter plasmids for UGT2B10
     SwitchGear Promoter luciferase reporter plasmids for UGT2B10
     Search ThermoFisher Antibodies for UGT2B10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT2B10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT2B10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGT2B10
     LSBio Antibodies in human, mouse, rat for UGT2B10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UGT2B10 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4