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Aliases for UGT2A3 Gene

Aliases for UGT2A3 Gene

  • UDP Glucuronosyltransferase Family 2 Member A3 2 3
  • UDP Glucuronosyltransferase 2 Family, Polypeptide A3 2 5
  • EC 2.4.1.17 4 63
  • UDPGT 2A3 4

External Ids for UGT2A3 Gene

Previous GeneCards Identifiers for UGT2A3 Gene

  • GC04M069975
  • GC04M069828
  • GC04M065589

Summaries for UGT2A3 Gene

GeneCards Summary for UGT2A3 Gene

UGT2A3 (UDP Glucuronosyltransferase Family 2 Member A3) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2A3 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2A3 Gene

Genomics for UGT2A3 Gene

Regulatory Elements for UGT2A3 Gene

Promoters for UGT2A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UGT2A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2A3 Gene

Chromosome:
4
Start:
68,928,459 bp from pter
End:
68,951,798 bp from pter
Size:
23,340 bases
Orientation:
Minus strand

Genomic View for UGT2A3 Gene

Genes around UGT2A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2A3 Gene

Proteins for UGT2A3 Gene

  • Protein details for UGT2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWM9-UD2A3_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2A3
    Protein Accession:
    Q6UWM9
    Secondary Accessions:
    • Q9H6S4

    Protein attributes for UGT2A3 Gene

    Size:
    527 amino acids
    Molecular mass:
    60254 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for UGT2A3 Gene

Proteomics data for UGT2A3 Gene at MOPED

Post-translational modifications for UGT2A3 Gene

  • Glycosylation at Asn 313
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT2A3 Gene

Gene Families for UGT2A3 Gene

Protein Domains for UGT2A3 Gene

Suggested Antigen Peptide Sequences for UGT2A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWM9

UniProtKB/Swiss-Prot:

UD2A3_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2A3: view

Function for UGT2A3 Gene

Molecular function for UGT2A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Enzyme Numbers (IUBMB) for UGT2A3 Gene

Gene Ontology (GO) - Molecular Function for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2A3: view

Phenotypes for UGT2A3 Gene

GenomeRNAi human phenotypes for UGT2A3:
genes like me logo Genes that share phenotypes with UGT2A3: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT2A3 Gene

Localization for UGT2A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2A3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2A3 Gene COMPARTMENTS Subcellular localization image for UGT2A3 gene
Compartment Confidence
golgi apparatus 3
endoplasmic reticulum 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT2A3: view

Pathways & Interactions for UGT2A3 Gene

genes like me logo Genes that share pathways with UGT2A3: view

Interacting Proteins for UGT2A3 Gene

Gene Ontology (GO) - Biological Process for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052696 flavonoid glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT2A3: view

No data available for SIGNOR curated interactions for UGT2A3 Gene

Drugs & Compounds for UGT2A3 Gene

(13) Drugs for UGT2A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 68
Estradiol Approved, Investigational Pharma Sex hormone 1094
Estriol Approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 19
Morphine Approved, Investigational Pharma Full agonist, Agonist 855

(82) Additional Compounds for UGT2A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT2A3: view

Transcripts for UGT2A3 Gene

Unigene Clusters for UGT2A3 Gene

UDP glucuronosyltransferase 2 family, polypeptide A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2A3 Gene

No ASD Table

Relevant External Links for UGT2A3 Gene

GeneLoc Exon Structure for
UGT2A3
ECgene alternative splicing isoforms for
UGT2A3

Expression for UGT2A3 Gene

mRNA expression in normal human tissues for UGT2A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2A3 Gene

This gene is overexpressed in Colon - Transverse (x16.4), Kidney - Cortex (x11.1), Small Intestine - Terminal Ileum (x10.2), Pancreas (x7.8), and Liver (x6.7).

Protein differential expression in normal tissues from HIPED for UGT2A3 Gene

This gene is overexpressed in Kidney (30.5), Pancreatic juice (13.6), and Rectum (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2A3 Gene



SOURCE GeneReport for Unigene cluster for UGT2A3 Gene Hs.122583

genes like me logo Genes that share expression patterns with UGT2A3: view

Protein tissue co-expression partners for UGT2A3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UGT2A3 Gene

Orthologs for UGT2A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2A3 35
  • 99.05 (n)
  • 98.29 (a)
UGT2A3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGT2A3 36
  • 74 (a)
OneToOne
UGT2A3 35
  • 80.01 (n)
  • 74.38 (a)
dog
(Canis familiaris)
Mammalia UGT2A1 35
  • 80.71 (n)
  • 74.57 (a)
UGT2A3 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ugt2a3 36
  • 66 (a)
OneToOne
Ugt2a3 16
Ugt2a3 35
  • 74.35 (n)
  • 68.57 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia UGT2A3 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugt2a3 35
  • 74.32 (n)
  • 70.43 (a)
chicken
(Gallus gallus)
Aves UGT2A3 35
  • 64.27 (n)
  • 59.14 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ugt2a1 35
  • 64.05 (n)
  • 58.55 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC571561 35
  • 59.95 (n)
  • 56.02 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006223 35
  • 45.87 (n)
  • 33.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ugt35b 35
  • 47.23 (n)
  • 34.98 (a)
Species with no ortholog for UGT2A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UGT2A3 Gene

ENSEMBL:
Gene Tree for UGT2A3 (if available)
TreeFam:
Gene Tree for UGT2A3 (if available)

Paralogs for UGT2A3 Gene

genes like me logo Genes that share paralogs with UGT2A3: view

Variants for UGT2A3 Gene

Sequence variations from dbSNP and Humsavar for UGT2A3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1458246 -- 68,952,364(+) ACAAT(A/C)GATAG upstream-variant-2KB
rs1054696 -- 68,928,709(-) CACTA(A/G)TAAGC nc-transcript-variant, utr-variant-3-prime
rs1598904 -- 68,948,068(+) cttca(A/G)agaca intron-variant
rs2017125 -- 68,930,830(-) GTAGT(C/T)TTTAA intron-variant
rs3828504 -- 68,929,343(-) AAGCC(C/T)TTCTA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UGT2A3 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
essv17788 CNV CNV 17122850
esv2727775 CNV Deletion 23290073
nsv436447 CNV Deletion 17901297
nsv4372 CNV Loss 18451855
dgv1634e1 CNV Complex 17122850
nsv829962 CNV Gain 17160897
nsv10519 CNV Gain 18304495

Variation tolerance for UGT2A3 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2A3 Gene

HapMap Linkage Disequilibrium report
UGT2A3
Human Gene Mutation Database (HGMD)
UGT2A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2A3 Gene

Disorders for UGT2A3 Gene

Relevant External Links for UGT2A3

Genetic Association Database (GAD)
UGT2A3
Human Genome Epidemiology (HuGE) Navigator
UGT2A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2A3

No disorders were found for UGT2A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2A3 Gene

Publications for UGT2A3 Gene

  1. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 48 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. (PMID: 19858781) Sneitz N. … Finel M. (Pharmacogenet. Genomics 2009) 3
  4. Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. (PMID: 18523138) Court M.H. … Williams J.A. (Mol. Pharmacol. 2008) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for UGT2A3 Gene

Sources for UGT2A3 Gene

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