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UGT2A3 Gene

protein-coding   GIFtS: 55
GCID: GC04M069828

UDP Glucuronosyltransferase 2 Family, Polypeptide A3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide A31 2
UDPGT 2A32 3
EC 2.4.1.173 8
UDP-Glucuronosyltransferase 2A32

External Ids:    HGNC: 285281   Entrez Gene: 797992   Ensembl: ENSG000001352207   UniProtKB: Q6UWM93   
ORGUL members:         

Export aliases for UGT2A3 gene to outside databases

Previous GC identifers: GC04M069975 GC04M065589


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UGT2A3 Gene:
UGT2A3 (UDP glucuronosyltransferase 2 family, polypeptide A3) is a protein-coding gene. Diseases associated with UGT2A3 include fascioliasis, and kernicterus. GO annotations related to this gene include glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD2A3_HUMAN, Q6UWM9
Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic
substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of
major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous
compounds (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NT_167250.2  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UGT2A3 gene promoter:
         HOXA3   SRF (504 AA)   E4BP4   HNF-1A   Gfi-1   YY1   IRF-2   POU2F1   HNF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGT2A3 promoter sequence
   Search Chromatin IP Primers for UGT2A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT2A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

UGT2A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2A3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M069828:  view genomic region     (about GC identifiers)

Start:
69,794,177 bp from pter      End:
69,817,509 bp from pter
Size:
23,333 bases      Orientation:
minus strand

2 alternative locations:
Chr4- 69,676,504-69,699,836      Chr4-,NT_167250 506,428-529,760     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UD2A3_HUMAN, Q6UWM9 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2A3 precursor  
Size: 527 amino acids; 60254 Da
Sequence caution: Sequence=BAB15179.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q9H6S4

Explore the universe of human proteins at neXtProt for UGT2A3: NX_Q6UWM9

Explore proteomics data for UGT2A3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn313
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGT2A3 (Q6UWM9) (see all 17)
     AFITHGG  SHWLNVK  CGKVLVW  LLGHPKT 


    See UGT2A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079019.3  
    ENSEMBL proteins: 
     ENSP00000251566   ENSP00000424092   ENSP00000440115  

    UGT2A3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q6UWM9

    ProtoNet protein and cluster: Q6UWM9

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD2A3_HUMAN, Q6UWM9
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT2A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD2A3_HUMAN, Q6UWM9
    Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic
    substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of
    major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous
    compounds (By similarity)
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015020glucuronosyltransferase activity IDA19858781
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    UGT2A3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT2A3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGT2A3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGT2A3

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UGT2A3

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    GenScript: all cDNA clones in your preferred vector: UGT2A3 (NM_024743)
    Sino Biological Human cDNA Clone for UGT2A3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT2A3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UD2A3_HUMAN, Q6UWM9: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    endoplasmic reticulum2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    UGT2A3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGT2A3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    3Metabolism of porphyrins
    Porphyrin and chlorophyll metabolism0.56
    4Biological oxidations
    metapathway biotransformation0.42
    5Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UGT2A3
        Glucuronidation
    metapathway biotransformation



    Selected Kegg Pathways  (Kegg details for UGT2A3) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT2A3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UGT2A3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UGT2A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT2A3 (ENSP000002515664) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    AKR1D1ENSP000002423754STRING: ENSP00000242375
    CES2ENSP000003178424STRING: ENSP00000317842
    CES5AENSP000002905674STRING: ENSP00000290567
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0008152metabolic process ----
    GO:0030259lipid glycosylation ----
    GO:0052695cellular glucuronidation IDA19858781

    UGT2A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT2A3 (UD2A3)

    Selected HMDB Compounds for UGT2A3 (see all 83)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----
    17-beta-estradiol glucuronide ----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UGT2A3 gene: 
    NM_024743.3  

    Unigene Cluster for UGT2A3:

    UDP glucuronosyltransferase 2 family, polypeptide A3
    Hs.122583  [show with all ESTs]
    Unigene Representative Sequence: NR_024010
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251566(uc010ihp.1 uc003hef.2) ENST00000503012 ENST00000420231

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      QuantiFast Probe-based Assays in human, mouse, rat UGT2A3

    Additional mRNA sequence: 

    AK025587.1 AK225308.1 AK293381.1 AY358727.1 AY542891.1 BC130533.1 NR_024010.1 

    2 DOTS entries:

    DT.202571  DT.92416451 

    Selected AceView cDNA sequences (see all 35):

    AK025587 AA779251 AY542891 BI837738 CK904555 AY358727 AW771510 BX483530 
    BM054672 CK904556 AI670866 BM054857 CB069553 AW301261 AI521955 NM_024743 
    BI964688 AI651431 BX494689 AI816782 CB069330 AI613083 BX499005 AW242566 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UGT2A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGCCATCA
    UGT2A3 Expression
    About this image

    UGT2A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT2A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122583
        Pathway & Disease-focused RT2 Profiler PCR Array including UGT2A3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UGT2A3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt2a31 , 5 UDP glucuronosyltransferase 2 family, polypeptide A31, 5 74.35(n)1
    68.57(a)1
      5 (43.56 cM)5
    720941  NM_028094.31  NP_082370.21 
     873249725 
    chicken
    (Gallus gallus)
    Aves UGT2A31 UDP glucuronosyltransferase 2 family, polypeptide A3 64.27(n)
    59.14(a)
      422660  XM_004941192.1  XP_004941249.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ugt2a11 UDP glucuronosyltransferase 2 family, polypeptide A1, more 64.05(n)
    58.55(a)
      447975  XM_002936464.2  XP_002936510.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5715611 UDP-glucuronosyltransferase 2B20-like 59.95(n)
    56.02(a)
      571561  XM_005162458.1  XP_005162515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ugt35b1 UDP-glycosyltransferase 35b 47.23(n)
    34.98(a)
      41333  NM_079589.3  NP_524313.2 


    ENSEMBL Gene Tree for UGT2A3 (if available)
    TreeFam Gene Tree for UGT2A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGT2A3 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  
    UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  
    UGT2B42  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    Selected SIMAP similar genes for UGT2A3 using alignment to 3 protein entries:     UD2A3_HUMAN (see all proteins) (see all similar genes):
    UGT2B17    UGT2B11    UGT2A1    UGT2B28    UGT2A2    UGT2B4
    UGT2B15    UGT2B10    UGT1A3S    UGT2B7    UGT1A9S    UGT1A8S
    UGT1A8    UGT1A6    UGT1A10    UGT8    UGT1A5    BILIQTL1

    UGT2A3 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for UGT2A3 (see all 9)
    PGOHUM00000245576 PGOHUM00000245581 PGOHUM00000245582 PGOHUM00000259938 PGOHUM00000250775


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UGT2A3 (see all 673)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130012391,2
    C--65596002(+) ACTCA-/GGA   
       ATTTT
    GGAAT
    2 -- int11Minor allele frequency- GGAATTTT:0.00CSA 2
    rs76744751,2
    C,F,A--69793765(+) AGTGTG/AAAATT 2 -- int112Minor allele frequency- A:0.32NA CSA WA EA 510
    rs1865666371,2
    --69793788(+) GCTGGA/GAGCTT 2 -- int10--------
    rs1428091741,2
    C--69793803(+) CAGGGA/GAGACA 2 -- int10--------
    rs21688401,2
    C,F,O,A,H--69793903(-) TTTTGA/CGATCA 2 -- int124Minor allele frequency- N:0.00EA NA NS 2798
    rs1915637071,2
    --69793992(+) CCAACC/TTAAAA 2 -- int10--------
    rs171470131,2
    C,F,H--69794076(+) GTTTAA/GTTACA 2 -- int123Minor allele frequency- G:0.09NA NS EA CSA WA 2676
    rs1510234081,2
    --69794223(+) ATACAC/TACACA 2 -- ut31 nc-transcript-variant0--------
    rs1426539371,2
    --69794286(+) TTGTAA/GATATA 2 -- ut31 nc-transcript-variant0--------
    rs1468942761,2
    --69794314(+) AGAATC/TTCAAA 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for UGT2A3 (69794177 - 69817509 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for UGT2A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436447CNV Deletion17901297
    esv2727775CNV Deletion23290073
    nsv4372CNV Loss18451855
    nsv10519CNV Gain18304495
    nsv829962CNV Gain17160897
    essv17788CNV CNV17122850
    dgv1628e1CNV Complex17122850
    dgv1634e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): UGT2A3
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing UGT2A3
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT2A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for UGT2A3:    
    About MalaCards
    fascioliasis    kernicterus    gilbert syndrome    malaria

    1 disease from the University of Copenhagen DISEASES database for UGT2A3:
    Gilbert syndrome

    UGT2A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UGT2A3
    Human Genome Epidemiology (HuGE) Navigator: UGT2A3 (2 documents)

    Export disorders for UGT2A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGT2A3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with UGT2A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. (PubMed id 19858781)1 Sneitz N.... Finel M. (Pharmacogenet. Genomics 2009)
    5. Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. (PubMed id 18523138)1 Court M.H....Williams J.A. (Mol. Pharmacol. 2008)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 79799 HGNC: 28528 AceView: FLJ21934 Ensembl:ENSG00000135220 euGenes: HUgn79799
    ECgene: UGT2A3 Kegg: 79799 H-InvDB: UGT2A3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UGT2A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UGT2A3 gene:
    Search GeneIP for patents involving UGT2A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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