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Aliases for UGT2A3 Gene

Aliases for UGT2A3 Gene

  • UDP Glucuronosyltransferase 2 Family, Polypeptide A3 2 3
  • EC 2.4.1.17 4 64
  • UDPGT 2A3 4

External Ids for UGT2A3 Gene

Summaries for UGT2A3 Gene

GeneCards Summary for UGT2A3 Gene

UGT2A3 (UDP Glucuronosyltransferase 2 Family, Polypeptide A3) is a Protein Coding gene. Diseases associated with UGT2A3 include gilbert syndrome. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2A3 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2A3 Gene

Genomics for UGT2A3 Gene

Genomic Location for UGT2A3 Gene

Start:
68,928,459 bp from pter
End:
68,951,791 bp from pter
Size:
23,333 bases
Orientation:
Minus strand

Genomic View for UGT2A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2A3 Gene

Regulatory Elements for UGT2A3 Gene

Proteins for UGT2A3 Gene

  • Protein details for UGT2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWM9-UD2A3_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2A3
    Protein Accession:
    Q6UWM9
    Secondary Accessions:
    • Q9H6S4

    Protein attributes for UGT2A3 Gene

    Size:
    527 amino acids
    Molecular mass:
    60254 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for UGT2A3 Gene

Proteomics data for UGT2A3 Gene at MOPED

Post-translational modifications for UGT2A3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn313

Other Protein References for UGT2A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for UGT2A3 Gene

Gene Families for UGT2A3 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT2A3 Gene

UniProtKB/Swiss-Prot:

UD2A3_HUMAN
Family:
  • Belongs to the UDP-glycosyltransferase family.:
    • Q6UWM9
genes like me logo Genes that share domains with UGT2A3: view

Function for UGT2A3 Gene

Molecular function for UGT2A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
UniProtKB/Swiss-Prot Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Enzyme Numbers (IUBMB) for UGT2A3 Gene

Gene Ontology (GO) - Molecular Function for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IDA 19858781
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT2A3: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT2A3 Gene

Localization for UGT2A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2A3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2A3 Gene COMPARTMENTS Subcellular localization image for UGT2A3 gene
Compartment Confidence
golgi apparatus 3
endoplasmic reticulum 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2A3: view

Pathways for UGT2A3 Gene

genes like me logo Genes that share pathways with UGT2A3: view

Pathways by source for UGT2A3 Gene

Interacting Proteins for UGT2A3 Gene

Gene Ontology (GO) - Biological Process for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0008152 metabolic process --
GO:0009813 flavonoid biosynthetic process IBA --
GO:0030259 lipid glycosylation --
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with UGT2A3: view

Compounds for UGT2A3 Gene

(83) HMDB Compounds for UGT2A3 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available
genes like me logo Genes that share compounds with UGT2A3: view

Transcripts for UGT2A3 Gene

Unigene Clusters for UGT2A3 Gene

UDP glucuronosyltransferase 2 family, polypeptide A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2A3 Gene

No ASD Table

Relevant External Links for UGT2A3 Gene

GeneLoc Exon Structure for
UGT2A3
ECgene alternative splicing isoforms for
UGT2A3

Expression for UGT2A3 Gene

mRNA expression in normal human tissues for UGT2A3 Gene

mRNA differential expression in normal tissues according to GTEx for UGT2A3 Gene

This gene is overexpressed in Colon - Transverse (16.4), Kidney - Cortex (11.1), Small Intestine - Terminal Ileum (10.2), Pancreas (7.8), and Liver (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2A3 Gene

SOURCE GeneReport for Unigene cluster for UGT2A3 Gene Hs.122583

genes like me logo Genes that share expressions with UGT2A3: view

Orthologs for UGT2A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2A3 36
  • 99.05 (n)
  • 98.29 (a)
UGT2A3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGT2A3 36
  • 80.01 (n)
  • 74.38 (a)
UGT2A3 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UGT2A1 36
  • 80.71 (n)
  • 74.57 (a)
UGT2A3 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ugt2a3 36
  • 74.35 (n)
  • 68.57 (a)
Ugt2a3 16
Ugt2a3 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UGT2A3 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugt2a3 36
  • 74.32 (n)
  • 70.43 (a)
chicken
(Gallus gallus)
Aves UGT2A3 36
  • 64.27 (n)
  • 59.14 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ugt2a1 36
  • 64.05 (n)
  • 58.55 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC571561 36
  • 59.95 (n)
  • 56.02 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006223 36
  • 45.87 (n)
  • 33.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ugt35b 36
  • 47.23 (n)
  • 34.98 (a)
Species with no ortholog for UGT2A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UGT2A3 Gene

ENSEMBL:
Gene Tree for UGT2A3 (if available)
TreeFam:
Gene Tree for UGT2A3 (if available)

Paralogs for UGT2A3 Gene

genes like me logo Genes that share paralogs with UGT2A3: view

Variants for UGT2A3 Gene

Sequence variations from dbSNP and Humsavar for UGT2A3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs969338 -- 68,940,602(+) atgat(C/G)agttg intron-variant
rs969339 -- 68,940,708(+) TATAA(A/G)ACTTA intron-variant
rs1054696 -- 68,928,709(-) CACTA(A/G)TAAGC utr-variant-3-prime, nc-transcript-variant
rs1117530 -- 68,941,637(+) ataaa(C/T)gggtt intron-variant
rs1117531 -- 68,941,751(+) gttac(C/T)atctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2A3 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
essv17788 CNV CNV 17122850
esv2727775 CNV Deletion 23290073
nsv436447 CNV Deletion 17901297
nsv4372 CNV Loss 18451855
dgv1634e1 CNV Complex 17122850
nsv829962 CNV Gain 17160897
nsv10519 CNV Gain 18304495

Relevant External Links for UGT2A3 Gene

HapMap Linkage Disequilibrium report
UGT2A3
Human Gene Mutation Database (HGMD)
UGT2A3

Disorders for UGT2A3 Gene

(1) MalaCards Diseases for UGT2A3 Gene

Search for UGT2A3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UGT2A3 Gene

Relevant External Links for UGT2A3

Genetic Association Database (GAD)
UGT2A3
Human Genome Epidemiology (HuGE) Navigator
UGT2A3
genes like me logo Genes that share disorders with UGT2A3: view

No data available for UniProtKB/Swiss-Prot for UGT2A3 Gene

Publications for UGT2A3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 49
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for UGT2A3 Gene

Sources for UGT2A3 Gene

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