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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT2A2 Gene

protein-coding   GIFtS: 37
GCID: GC04M070489

UDP Glucuronosyltransferase 2 Family, Polypeptide A2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 2 Family, Polypeptide A21 2
EC 2.4.1.173 8
UDP-Glucuronosyltransferase 2A22
UDPGT 2A13

External Ids:    HGNC: 281831   Entrez Gene: 5745372   Ensembl: ENSG000002712717   UniProtKB: Q9Y4X13   

Export aliases for UGT2A2 gene to outside databases

Previous GC identifer: GC04U900457


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UGT2A2 Gene: 
UGT2A2 (UDP glucuronosyltransferase 2 family, polypeptide A2) is a protein-coding gene. Diseases associated with UGT2A2 include cytochrome p450, and among its related super-pathways are Ascorbate and aldarate metabolism and Drug metabolism - cytochrome P450. An important paralog of this gene is UGT1A8.

UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1
Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic
substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of
major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous
compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant
molecules from the sensory epithelium

Gene Wiki entry for UGT2A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT2A2 gene promoter:
         Sox5   oct-B3   STAT5A   Tal-1beta   Cdc5   E47   POU2F1   POU2F1a   HSF2   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UGT2A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

UGT2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT2A2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M070489:  view genomic region     (about GC identifiers)

Start:
70,454,135 bp from pter      End:
70,505,360 bp from pter
Size:
51,226 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 2A1 precursor  
Size: 527 amino acids; 59926 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Caution: According to HGNC, UGT2A1 and UGT2A2 are 2 separate genes. However, they share common exons at the
C-terminus, suggesting that UGT2A1 and UGT2A2 are different isoforms encoded by the same locus
Secondary accessions: B4E2F4 D3GER1 D3GER2 E9PDM7 J3KNA3
Alternative splicing: 5 isoforms:  Q9Y4X1-1   Q9Y4X1-2   Q9Y4X1-3   Q9Y4X1-4   Q9Y4X1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UGT2A2: NX_Q9Y4X1

Explore proteomics data for UGT2A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4X1

  • 4/19 DME Specific Peptides for UGT2A2 (Q9Y4X1) (see all 19)
     AFITHGG  SHWLNVK  LLGHPKT  QYHSLDV 

    UGT2A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGT2A2 Protein Expression
    REFSEQ proteins: NP_001099147.2  
    ENSEMBL proteins: 
     ENSP00000475028   ENSP00000474383   ENSP00000387888  
    Reactome Protein details: Q9Y4X1
    Human Recombinant Protein Products for UGT2A2: 
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    Cloud-Clone Corp. Proteins for UGT2A2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane ----

    UGT2A2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q9Y4X1

    ProtoNet protein and cluster: Q9Y4X1

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT2A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD2A1_HUMAN, Q9Y4X1
    Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic
    substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of
    major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous
    compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant
    molecules from the sensory epithelium
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
    Biophysicochemical properties: Kinetic parameters: KM=75.4 uM for 3-hydroxybiphenyl; KM=59.5 uM for umbelliferone;
    KM=51.6 uM for S-(-)-b-citronellol; KM=170.1 uM for borneol; KM=56.2 uM for testosterone; KM=251 uM for
    UDP-glucuronate; Vmax=2.60 nmol/min/mg enzyme with 3-hydroxybiphenyl as substrate; Vmax=0.61 nmol/min/mg enzyme
    with umbelliferone as substrate; Vmax=1.98 nmol/min/mg enzyme with S-(-)-b-citronellol as substrate; Vmax=1.05
    nmol/min/mg enzyme with borneol as substrate; Vmax=0.25 nmol/min/mg enzyme with testosterone as substrate;

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015020glucuronosyltransferase activity ----
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    UGT2A2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UGT2A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.67
    Porphyrin and chlorophyll metabolism0.38
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.33
    Pentose and glucuronate interconversions0.61
    Steroid hormone biosynthesis0.30
    Starch and sucrose metabolism0.41
    2Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    Retinol metabolism0.39
    3Biological oxidations
    metapathway biotransformation0.41
    4Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UGT2A2
        Glucuronidation
    metapathway biotransformation

    4        Reactome Pathways for UGT2A2
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation


    5/11         Kegg Pathways  (Kegg details for UGT2A2) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT2A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT2A2

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0007608sensory perception of smell ----
    GO:0008152metabolic process ----
    GO:0009593detection of chemical stimulus ----
    GO:0030259lipid glycosylation ----

    UGT2A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT2A2 (UD2A1)

    Search CenterWatch for drugs/clinical trials and news about UGT2A2 / UD2A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGT2A2 gene: 
    NM_001105677.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604629 ENST00000604021 ENST00000457664(uc010ihs.3 uc021xox.1)

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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT2A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT2A2 Expression
    About this image


    See UGT2A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT2A2

    UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1
    Tissue specificity: Olfactory epithelium and brain. Isoform 2 is mainly expressed in the nasal mucosa

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT2A2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt2a21 , 5 UDP glucuronosyltransferase 2 family, polypeptide A21, 5 85.23(n)1
    84.85(a)1
      5 (43.56 cM)5
    5528991  NM_001024148.11  NP_001019319.11 
     874594935 
    chicken
    (Gallus gallus)
    Aves --
    --
    58(a)
    possible ortholog
    4(51190837-51197770)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    62(a)
    62(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    6(58626676-58649813)
    6(58560593-58594758)


    ENSEMBL Gene Tree for UGT2A2 (if available)
    TreeFam Gene Tree for UGT2A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT2A2 gene
    UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  UGT3A22  
    UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  

    UGT2A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for UGT2A2 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658506CNV Deletion23128226
    dgv93n16CNV Deletion17901297
    esv1001272CNV Deletion20482838
    dgv659n27CNV Loss19166990
    nsv521416CNV Loss19592680
    esv24189CNV Loss19812545
    nsv499046CNV Loss21111241
    nsv511264CNV Loss21212237
    nsv461552CNV Loss19166990
    nsv514225CNV Loss21397061

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for UGT2A2:    About MalaCards
    cytochrome p450    


    UGT2A2 for disorders           About GeneDecksing


    Export disorders for UGT2A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT2A2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with UGT2A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human UDP-glucuronosyltransferase UGT2A2: cDNA constr uction, expression, and functional characterization in comparison with UGT2A1 a nd UGT2A3. (PubMed id 19858781)1, 2 Sneitz N....Finel M. (2009)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. Cloning and characterization of a novel human olfactory UDP- glucuronosyltransferase. (PubMed id 10359671)1, 2 Jedlitschky G.A.... Burchell B. (1999)
    4. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. (PubMed id 16141793)1, 9 Mackenzie P.I....Nebert D.W. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 574537 HGNC: 28183 Ensembl:ENSG00000271271 euGenes: HUgn574537 ECgene: UGT2A2 Kegg: 574537
    H-InvDB: UGT2A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT2A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGT2A2 gene:
    Search GeneIP for patents involving UGT2A2

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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