UGT2A2 Gene
protein-coding GIFtS: 38
GCID: GC04M070489
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UDP glucuronosyltransferase 2 family, polypeptide A2
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Aliases
for UGT2A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UDP Glucuronosyltransferase 2 Family, Polypeptide A21 2 | | EC 2.4.1.173 8 | | UDP-Glucuronosyltransferase 2A22 | | UDPGT 2A13 |
Export aliases for UGT2A2 gene to outside databasesPrevious GC identifer: GC04U900457 |
Summaries
for UGT2A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates areconjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance inthe conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active onodorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensoryepithelium
Gene Wiki entry for UGT2A2
|
Genomic Views
for UGT2A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UGT2A2 gene promoter:
Sox5 oct-B3 STAT5A Tal-1beta Cdc5 E47 POU2F1 POU2F1a HSF2 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for UGT2A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT2A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.3 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3UGT2A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M070489: view genomic region
(about GC identifiers)
Start:
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70,454,135 bp from pter |
End:
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70,518,967 bp from pter |
Size:
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64,833 bases |
Orientation:
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minus strand |
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Proteins
for UGT2A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1 (See
protein sequence)Recommended Name: UDP-glucuronosyltransferase 2A1 precursor Size: 527 amino acids; 59926 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Caution: According to HGNC, UGT2A1 and UGT2A2 are 2 separate genes. However, they share common exons at the C-terminus,suggesting that UGT2A1 and UGT2A2 are different isoforms encoded by the same locus
Secondary accessions: B4E2F4 D3GER1 D3GER2 E9PDM7 J3KNA3Alternative splicing: 5 isoforms: Q9Y4X1-1 Q9Y4X1-2 Q9Y4X1-3 Q9Y4X1-4 Q9Y4X1-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UGT2A2: NX_Q9Y4X1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4X1
4/19 DME Specific Peptides for UGT2A2 (Q9Y4X1) (see all 19)
UGT2A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001099147.2
ENSEMBL proteins: ENSP00000424478 ENSP00000421432 ENSP00000425497 ENSP00000286604 ENSP00000427709 ENSP00000387888 Reactome Protein details: Q9Y4X1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
-- | -- |
UGT2A2 for ontologies About GeneDecksing
UGT2A2 Antibody Products:
Assay Products for UGT2A2: |
Protein
Domains /
Families
for UGT2A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UGT2A2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y4X1ProtoNet protein and cluster: Q9Y4X1 1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase
UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1Similarity: Belongs to the UDP-glycosyltransferase family |
Function
for UGT2A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates areconjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance inthe conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active onodorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensoryepitheliumCatalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronosideBiophysicochemical properties: Kinetic parameters: KM=75.4 uM for 3-hydroxybiphenyl; KM=59.5 uM for umbelliferone;KM=51.6 uM for S-(-)-b-citronellol; KM=170.1 uM for borneol; KM=56.2 uM for testosterone; KM=251 uM forUDP-glucuronate; Vmax=2.60 nmol/min/mg enzyme with 3-hydroxybiphenyl as substrate; Vmax=0.61 nmol/min/mg enzyme withumbelliferone as substrate; Vmax=1.98 nmol/min/mg enzyme with S-(-)-b-citronellol as substrate; Vmax=1.05 nmol/min/mgenzyme with borneol as substrate; Vmax=0.25 nmol/min/mg enzyme with testosterone as substrate;Enzyme Number (IUBMB): EC 2.4.1.171 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT2A2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2A2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015020 | glucuronosyltransferase activity |
-- | -- | | GO:0016758 | transferase activity, transferring hexosyl groups |
-- | -- |
UGT2A2 for ontologies About GeneDecksing
|
Pathways & Interactions
for UGT2A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glucuronidation | | | 2 | Drug metabolism - cytochrome P450 | | | 3 | Pentose and glucuronate interconversions | | | 4 | Steroid hormone biosynthesis | | | 5 | Biological oxidations | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for UGT2A2
4 
Reactome Pathways for UGT2A2
5/11 
Kegg Pathways (Kegg details for UGT2A2) (see all 11):
UGT2A2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT2A2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/56 Interacting proteins for UGT2A2 (ENSP000002866044) via UniProtKB, MINT, STRING, and/or I2D (see all 56)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
UGT2A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for UGT2A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UGT2A2
Search CenterWatch for drugs/clinical trials and news about UGT2A2 / UD2A1
|
Transcripts
for UGT2A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UGT2A2 gene: NM_001105677.2 8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000503640(uc003hem.4 uc011caq.2 uc010ihu.3) ENST00000512704(uc010iht.3)
ENST00000514019 ENST00000286604 ENST00000502343 ENST00000514341 ENST00000505512
ENST00000457664(uc010ihs.3 uc021xox.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT2A2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT2A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UGT2A2 (NM_001105677) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UGT2A2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UGT2A2 |
GeneLoc Exon Structure
|
Expression
for UGT2A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UGT2A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See UGT2A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UGT2A2
UniProtKB/Swiss-Prot: UD2A1_HUMAN, Q9Y4X1Tissue specificity: Olfactory epithelium and brain. Isoform 2 is mainly expressed in the nasal mucosa
SABiosciences Custom PCR Arrays for UGT2A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT2A2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat UGT2A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGT2A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT2A2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2A2 |
Orthologs
for UGT2A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for UGT2A2 (if available)
TreeFam Gene Tree for UGT2A2 (if available) |
Paralogs
for UGT2A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UGT2A2 gene
- UGT1A82 UGT1A72 UGT3A12 UGT2B72 UGT2B112 UGT1A32 UGT1A12 UGT1A52
- UGT3A22 UGT2B102 UGT1A102 UGT1A62 UGT82 UGT2B152 UGT2B42 UGT2B172
- UGT2A32 UGT2B282 UGT1A92 UGT1A42
UGT2A2 for paralogs About GeneDecksing
|
Genomic Variants
for UGT2A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for UGT2A2
15 CNVs: 92191 80359 92189 23048 22681 36292 80360 92188 7451 6276 53271 80358 36293 92190 63855
1 Indel: 80361 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT2A2 |
|
Disorders
/ Diseases
for UGT2A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for UGT2A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UGT2A2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with UGT2A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human UDP-glucuronosyltransferase UGT2A2: cDNA constr uction, expression, and functional characterization in comparison with UGT2A1 a nd UGT2A3. (PubMed id 19858781)1, 2 Sneitz N....Finel M. (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Cloning and characterization of a novel human olfactory UDP- glucuronosyltransferase. (PubMed id 10359671)1, 2 Jedlitschky G.A.... Burchell B. (1999)
- Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. (PubMed id 16141793)1, 9 Mackenzie P.I....Nebert D.W. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for UGT2A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing UGT2A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UGT2A2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UGT2A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UGT2A2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UGT2A2 gene:
Search GeneIP for patents involving UGT2A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UGT2A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | UGT2A2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT2A2 |
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