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Aliases for UGT2A2 Gene

Aliases for UGT2A2 Gene

  • UDP Glucuronosyltransferase 2 Family, Polypeptide A2 2 3
  • EC 2.4.1.17 4 63
  • UDPGT 2A1 4
  • UGT2A1 4

External Ids for UGT2A2 Gene

Previous GeneCards Identifiers for UGT2A2 Gene

  • GC04U900457
  • GC04M070489
  • GC04M070455

Summaries for UGT2A2 Gene

GeneCards Summary for UGT2A2 Gene

UGT2A2 (UDP Glucuronosyltransferase 2 Family, Polypeptide A2) is a Protein Coding gene. Among its related pathways are Metabolism and Chemical carcinogenesis. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2A2 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Gene Wiki entry for UGT2A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2A2 Gene

Genomics for UGT2A2 Gene

Regulatory Elements for UGT2A2 Gene

Genomic Location for UGT2A2 Gene

Start:
69,588,417 bp from pter
End:
69,639,642 bp from pter
Size:
51,226 bases
Orientation:
Minus strand

Genomic View for UGT2A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2A2 Gene

Proteins for UGT2A2 Gene

  • Protein details for UGT2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X1-UD2A1_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2A1
    Protein Accession:
    Q9Y4X1
    Secondary Accessions:
    • B4E2F4
    • D3GER1
    • D3GER2
    • E9PDM7
    • J3KNA3

    Protein attributes for UGT2A2 Gene

    Size:
    527 amino acids
    Molecular mass:
    59926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2A2 Gene

Proteomics data for UGT2A2 Gene at MOPED

Post-translational modifications for UGT2A2 Gene

  • Glycosylation at Asn49, Asn313, and Asn347
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UGT2A2 Gene

Gene Families for UGT2A2 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT2A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4X1

UniProtKB/Swiss-Prot:

UD2A1_HUMAN :
  • Q9Y4X1
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2A2: view

No data available for Suggested Antigen Peptide Sequences for UGT2A2 Gene

Function for UGT2A2 Gene

Molecular function for UGT2A2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=75.4 uM for 3-hydroxybiphenyl {ECO:0000269 PubMed:10359671}; KM=59.5 uM for umbelliferone {ECO:0000269 PubMed:10359671}; KM=51.6 uM for S-(-)-b-citronellol {ECO:0000269 PubMed:10359671}; KM=170.1 uM for borneol {ECO:0000269 PubMed:10359671}; KM=56.2 uM for testosterone {ECO:0000269 PubMed:10359671}; KM=251 uM for UDP-glucuronate {ECO:0000269 PubMed:10359671}; Vmax=2.60 nmol/min/mg enzyme with 3-hydroxybiphenyl as substrate {ECO:0000269 PubMed:10359671}; Vmax=0.61 nmol/min/mg enzyme with umbelliferone as substrate {ECO:0000269 PubMed:10359671}; Vmax=1.98 nmol/min/mg enzyme with S-(-)-b-citronellol as substrate {ECO:0000269 PubMed:10359671}; Vmax=1.05 nmol/min/mg enzyme with borneol as substrate {ECO:0000269 PubMed:10359671}; Vmax=0.25 nmol/min/mg enzyme with testosterone as substrate {ECO:0000269 PubMed:10359671};
UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
UniProtKB/Swiss-Prot Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Enzyme Numbers (IUBMB) for UGT2A2 Gene

Gene Ontology (GO) - Molecular Function for UGT2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity --
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT2A2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT2A2 Gene

Localization for UGT2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2A2 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for UGT2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with UGT2A2: view

No data available for Subcellular locations from COMPARTMENTS for UGT2A2 Gene

Pathways for UGT2A2 Gene

genes like me logo Genes that share pathways with UGT2A2: view

Pathways by source for UGT2A2 Gene

Interacting Proteins for UGT2A2 Gene

Gene Ontology (GO) - Biological Process for UGT2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0007608 sensory perception of smell --
GO:0008152 metabolic process --
GO:0009593 detection of chemical stimulus --
GO:0030259 lipid glycosylation --
genes like me logo Genes that share ontologies with UGT2A2: view

Transcripts for UGT2A2 Gene

mRNA/cDNA for UGT2A2 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2A2 Gene

No ASD Table

Relevant External Links for UGT2A2 Gene

GeneLoc Exon Structure for
UGT2A2
ECgene alternative splicing isoforms for
UGT2A2

Expression for UGT2A2 Gene

mRNA expression in normal human tissues for UGT2A2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for UGT2A2 Gene

mRNA Expression by UniProt/SwissProt for UGT2A2 Gene

Q9Y4X1-UD2A1_HUMAN
Tissue specificity: Olfactory epithelium and brain. Isoform 2 is mainly expressed in the nasal mucosa.
genes like me logo Genes that share expressions with UGT2A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UGT2A2 Gene

Orthologs for UGT2A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UGT2A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
UGT2A1 35
  • 99.75 (n)
  • 99.44 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt2a2 35
  • 85.21 (n)
  • 85.08 (a)
Ugt2a2 16
Ugt2b5 36
  • 56 (a)
ManyToMany
Species with no ortholog for UGT2A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UGT2A2 Gene

ENSEMBL:
Gene Tree for UGT2A2 (if available)
TreeFam:
Gene Tree for UGT2A2 (if available)

Paralogs for UGT2A2 Gene

genes like me logo Genes that share paralogs with UGT2A2: view

Variants for UGT2A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for UGT2A2 Gene

Variant ID Type Subtype PubMed ID
nsv510892 CNV Complex 20534489
nsv879444 CNV Loss 21882294
nsv4377 CNV Loss 18451855
esv33983 CNV Gain+Loss 17666407
esv1001272 CNV Deletion 20482838
esv24189 CNV Loss 19812545
dgv93n16 CNV Deletion 17901297
esv2658506 CNV Deletion 23128226
nsv499046 CNV Loss 21111241
nsv514225 CNV Loss 21397061
nsv822601 CNV Loss 20364138
nsv511264 CNV Loss 21212237
dgv5625n71 CNV Loss 21882294
nsv879446 CNV Loss 21882294
nsv521416 CNV Loss 19592680
dgv659n27 CNV Loss 19166990
nsv461552 CNV Loss 19166990
nsv292823 CNV Loss 16902084
nsv879448 CNV Gain 21882294
nsv879449 CNV Loss 21882294

Relevant External Links for UGT2A2 Gene

HapMap Linkage Disequilibrium report
UGT2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for UGT2A2 Gene

Disorders for UGT2A2 Gene

No disorders were found for UGT2A2 Gene.

No data available for UniProtKB/Swiss-Prot for UGT2A2 Gene

Publications for UGT2A2 Gene

  1. Cloning and characterization of a novel human olfactory UDP- glucuronosyltransferase. (PMID: 10359671) Jedlitschky G.A. … Burchell B. (Biochem. J. 1999) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. (PMID: 19858781) Sneitz N. … Finel M. (Pharmacogenet. Genomics 2009) 3 4
  4. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. (PMID: 16141793) Mackenzie P.I. … Nebert D.W. (Pharmacogenet. Genomics 2005) 3 23
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3

Products for UGT2A2 Gene

Sources for UGT2A2 Gene

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