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Aliases for UGT2A1 Gene

Aliases for UGT2A1 Gene

  • UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus 2 3 5
  • UDP Glucuronosyltransferase 2 Family, Polypeptide A1, Complex Locus 2 3
  • UDP Glycosyltransferase 2 Family, Polypeptide A1 2 3
  • EC 2.4.1.17 4 61
  • Uridine Diphosphate Glycosyltransferase 2 Family, Member A1 3
  • UDP-Glucuronosyltransferase 2A1 3
  • UDPGT 2A1 4
  • UDPGT2A1 3
  • UGT2A2 4

External Ids for UGT2A1 Gene

Previous GeneCards Identifiers for UGT2A1 Gene

  • GC04P070020
  • GC04M070503
  • GC04M070704
  • GC04M070770
  • GC04M070635
  • GC04M070454

Summaries for UGT2A1 Gene

Entrez Gene Summary for UGT2A1 Gene

  • The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for UGT2A1 Gene

UGT2A1 (UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot for UGT2A1 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Gene Wiki entry for UGT2A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2A1 Gene

Genomics for UGT2A1 Gene

Regulatory Elements for UGT2A1 Gene

Enhancers for UGT2A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F069689 0.8 Ensembl 0.3 -36.5 -36536 0.4 GATAD2A CTCF ZNF654 TEAD1 REST RAD21 CEBPA SMC3 UGT2A1 GC04P069761
GH04F069726 0.6 Ensembl ENCODE 0.2 -73.9 -73935 2.0 SOX13 PKNOX1 ZNF362 NR3C1 RAD21 ZNF843 YY1 HIC1 ATF3 PBX2 SULT1B1 CSN1S1 GC04P069761 UGT2A1
GH04F069707 0.6 ENCODE 0.2 -55.3 -55276 2.0 JUN TCF7L2 CSN1S1 GC04P069761 UGT2A1
GH04F069718 1.4 FANTOM5 Ensembl ENCODE 0.2 -65.7 -65749 1.6 JUN FEZF1 ZNF664 ZNF335 ZNF366 SCRT2 PATZ1 FOS ZNF600 PRDM10 SULT1E1 SULT1B1 CSN1S1 GC04P069761 UGT2A1
GH04F069713 0.5 FANTOM5 Ensembl 0.2 -60.7 -60652 0.6 ELF3 MLX ARID4B RAD21 RARA YY1 HSF1 MIXL1 THAP11 HMG20B SULT1B1 CSN1S1 GC04P069761 UGT2A1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UGT2A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2A1 Gene

Chromosome:
4
Start:
69,588,417 bp from pter
End:
69,653,249 bp from pter
Size:
64,833 bases
Orientation:
Minus strand

Genomic View for UGT2A1 Gene

Genes around UGT2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2A1 Gene

Proteins for UGT2A1 Gene

  • Protein details for UGT2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X1-UD2A1_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2A1
    Protein Accession:
    Q9Y4X1
    Secondary Accessions:
    • B4E2F4
    • D3GER1
    • D3GER2
    • E9PDM7
    • J3KNA3

    Protein attributes for UGT2A1 Gene

    Size:
    527 amino acids
    Molecular mass:
    59926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2A1 Gene

Selected DME Specific Peptides for UGT2A1 Gene

Q9Y4X1:
  • AFITHGG
  • SHWLNVK
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • AAHDLTW
  • KPLDRAVFWIE
  • YWDFEFPRP
  • YEAIYHG
  • FVGGLHC
  • DVIGFLL
  • WIPQNDLLG
  • IPQKVLW
  • DQPDNIAHMK
  • VVFSLGSMV
  • VMRHKGA
  • LSRIHHDQP
  • QYHSLDV
  • VALKLGIPF

Post-translational modifications for UGT2A1 Gene

  • Glycosylation at Asn 49, Asn 313, and Asn 347
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2A1 Gene

Domains & Families for UGT2A1 Gene

Gene Families for UGT2A1 Gene

Protein Domains for UGT2A1 Gene

Suggested Antigen Peptide Sequences for UGT2A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4X1

UniProtKB/Swiss-Prot:

UD2A1_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2A1: view

Function for UGT2A1 Gene

Molecular function for UGT2A1 Gene

GENATLAS Biochemistry:
UDP glucoronosyltransferase 2 alpha 1,specific for the olfactory tissue
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=75.4 uM for 3-hydroxybiphenyl {ECO:0000269 PubMed:10359671}; KM=59.5 uM for umbelliferone {ECO:0000269 PubMed:10359671}; KM=51.6 uM for S-(-)-b-citronellol {ECO:0000269 PubMed:10359671}; KM=170.1 uM for borneol {ECO:0000269 PubMed:10359671}; KM=56.2 uM for testosterone {ECO:0000269 PubMed:10359671}; KM=251 uM for UDP-glucuronate {ECO:0000269 PubMed:10359671}; Vmax=2.60 nmol/min/mg enzyme with 3-hydroxybiphenyl as substrate {ECO:0000269 PubMed:10359671}; Vmax=0.61 nmol/min/mg enzyme with umbelliferone as substrate {ECO:0000269 PubMed:10359671}; Vmax=1.98 nmol/min/mg enzyme with S-(-)-b-citronellol as substrate {ECO:0000269 PubMed:10359671}; Vmax=1.05 nmol/min/mg enzyme with borneol as substrate {ECO:0000269 PubMed:10359671}; Vmax=0.25 nmol/min/mg enzyme with testosterone as substrate {ECO:0000269 PubMed:10359671};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Enzyme Numbers (IUBMB) for UGT2A1 Gene

Gene Ontology (GO) - Molecular Function for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2A1: view
genes like me logo Genes that share phenotypes with UGT2A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UGT2A1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2A1 Gene

Localization for UGT2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2A1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2A1 Gene COMPARTMENTS Subcellular localization image for UGT2A1 gene
Compartment Confidence
golgi apparatus 3
peroxisome 3
cytoskeleton 1
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2A1: view

Pathways & Interactions for UGT2A1 Gene

genes like me logo Genes that share pathways with UGT2A1: view

Interacting Proteins for UGT2A1 Gene

Gene Ontology (GO) - Biological Process for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007608 sensory perception of smell IEA --
GO:0008152 metabolic process IEA,TAS 10359671
GO:0009593 detection of chemical stimulus TAS 10359671
GO:0009813 flavonoid biosynthetic process IBA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with UGT2A1: view

No data available for SIGNOR curated interactions for UGT2A1 Gene

Drugs & Compounds for UGT2A1 Gene

(14) Drugs for UGT2A1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 74
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1283
Estriol Approved, Vet_approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 21
Morphine Approved, Investigational Pharma Full agonist, Agonist 960

(81) Additional Compounds for UGT2A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT2A1: view

Transcripts for UGT2A1 Gene

mRNA/cDNA for UGT2A1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UGT2A1 Gene

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2A1 Gene

No ASD Table

Relevant External Links for UGT2A1 Gene

GeneLoc Exon Structure for
UGT2A1
ECgene alternative splicing isoforms for
UGT2A1

Expression for UGT2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UGT2A1 Gene

This gene is overexpressed in Nasal epithelium (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UGT2A1 Gene



Protein tissue co-expression partners for UGT2A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT2A1 Gene:

UGT2A1

SOURCE GeneReport for Unigene cluster for UGT2A1 Gene:

Hs.225950

mRNA Expression by UniProt/SwissProt for UGT2A1 Gene:

Q9Y4X1-UD2A1_HUMAN
Tissue specificity: Olfactory epithelium and brain. Isoform 2 is mainly expressed in the nasal mucosa.
genes like me logo Genes that share expression patterns with UGT2A1: view

Primer Products

No data available for mRNA differential expression in normal tissues for UGT2A1 Gene

Orthologs for UGT2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ugt2a1 34 16 35
  • 85.31 (n)
rat
(Rattus norvegicus)
Mammalia Ugt2a1 34
  • 85.05 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii Dr.11419 34
fruit fly
(Drosophila melanogaster)
Insecta Ugt86Dc 36
  • 37 (a)
Ugt86Dd 36
  • 36 (a)
Ugt86Dg 36
  • 35 (a)
Ugt86Di 36
  • 35 (a)
Ugt86Dj 36
  • 35 (a)
Ugt35a 36
  • 34 (a)
Ugt86De 36
  • 34 (a)
CG6475 36
  • 33 (a)
BEST:GH09393 36
  • 32 (a)
Ugt35b 36
  • 32 (a)
Ugt86Da 36
  • 32 (a)
CG5999 36
  • 31 (a)
BEST:GH06505 36
  • 30 (a)
Ugt37c1 36
  • 30 (a)
Ugt36Bb 36
  • 28 (a)
Ugt37a1 36
  • 28 (a)
CG17323 36
  • 27 (a)
Ugt36Ba 36
  • 27 (a)
Ugt36Bc 36
  • 27 (a)
CG10168 36
  • 25 (a)
CG10170 36
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea F39G3.1 36
  • 32 (a)
M88.1 36
  • 32 (a)
C17G1.3 36
  • 28 (a)
AC3.2 36
  • 27 (a)
C44H9.1 36
  • 27 (a)
F35H8.6 36
  • 27 (a)
F56B3.7 36
  • 27 (a)
T07C5.1a 36
  • 27 (a)
C33A12.6 36
  • 26 (a)
C10H11.4 36
  • 25 (a)
C10H11.5 36
  • 25 (a)
R04B5.9 36
  • 25 (a)
T03D3.1 36
  • 25 (a)
ZC443.5 36
  • 25 (a)
F01D4.1 36
  • 24 (a)
F47C10.6 36
  • 24 (a)
T19H12.11 36
  • 24 (a)
C03A7.11 36
  • 23 (a)
C08B6.1 36
  • 23 (a)
F01D4.2 36
  • 23 (a)
Species where no ortholog for UGT2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT2A1 Gene

ENSEMBL:
Gene Tree for UGT2A1 (if available)
TreeFam:
Gene Tree for UGT2A1 (if available)

Paralogs for UGT2A1 Gene

Variants for UGT2A1 Gene

Sequence variations from dbSNP and Humsavar for UGT2A1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000435 -- 69,650,953(+) CAGTG(C/T)GCAAA intron-variant
rs10001991 -- 69,626,252(+) GATCA(C/T)ATTCT intron-variant
rs10004306 -- 69,604,190(+) caaag(A/G)gaagc intron-variant
rs10005934 -- 69,627,949(+) ATATT(C/T)ACTTC intron-variant
rs10006049 -- 69,628,108(+) CTATG(C/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2A1 Gene

Variant ID Type Subtype PubMed ID
dgv146n73 CNV deletion 24416366
dgv5318n100 CNV loss 25217958
dgv659n27 CNV loss 19166990
dgv9119n54 CNV loss 21841781
dgv9120n54 CNV gain 21841781
dgv9121n54 CNV loss 21841781
dgv9122n54 CNV loss 21841781
dgv9123n54 CNV gain 21841781
dgv9124n54 CNV loss 21841781
dgv9125n54 CNV loss 21841781
dgv93n16 CNV deletion 17901297
esv1001272 CNV deletion 20482838
esv24189 CNV loss 19812545
esv2658506 CNV deletion 23128226
esv33983 CNV gain+loss 17666407
esv3564042 CNV deletion 23714750
esv3569511 CNV loss 25503493
esv3600917 CNV loss 21293372
esv3600919 CNV loss 21293372
nsv1009165 CNV loss 25217958
nsv1074182 CNV deletion 25765185
nsv1122088 CNV deletion 24896259
nsv292823 CNV deletion 16902084
nsv4377 CNV deletion 18451855
nsv461552 CNV loss 19166990
nsv476466 CNV novel sequence insertion 20440878
nsv499046 CNV loss 21111241
nsv510892 OTHER complex 20534489
nsv511264 CNV loss 21212237
nsv514225 CNV loss 21397061
nsv521416 CNV loss 19592680
nsv594616 CNV loss 21841781
nsv594630 CNV loss 21841781
nsv594636 CNV loss 21841781
nsv594637 CNV loss 21841781
nsv594640 CNV loss 21841781
nsv822601 CNV loss 20364138
nsv966281 CNV duplication 23825009
nsv998374 CNV gain 25217958

Variation tolerance for UGT2A1 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2A1 Gene

Human Gene Mutation Database (HGMD)
UGT2A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2A1 Gene

Disorders for UGT2A1 Gene

Relevant External Links for UGT2A1

Genetic Association Database (GAD)
UGT2A1
Human Genome Epidemiology (HuGE) Navigator
UGT2A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2A1

No disorders were found for UGT2A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2A1 Gene

Publications for UGT2A1 Gene

  1. Cloning and characterization of a novel human olfactory UDP- glucuronosyltransferase. (PMID: 10359671) Jedlitschky G.A. … Burchell B. (Biochem. J. 1999) 2 3 4 64
  2. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64
  3. Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. (PMID: 19858781) Sneitz N. … Finel M. (Pharmacogenet. Genomics 2009) 3 4 64
  4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 46 64
  5. Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent. (PMID: 23372764) Manevski N. … Finel M. (PLoS ONE 2013) 3 64

Products for UGT2A1 Gene

Sources for UGT2A1 Gene

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