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Aliases for UGT2A1 Gene

Aliases for UGT2A1 Gene

  • UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus 2 3
  • UDP Glucuronosyltransferase 2 Family, Polypeptide A1, Complex Locus 2 3 5
  • UDP Glycosyltransferase 2 Family, Polypeptide A1 2 3
  • EC 2.4.1.17 4 63
  • Uridine Diphosphate Glycosyltransferase 2 Family, Member A1 3
  • UDPGT 2A1 4
  • UDPGT2A1 3
  • UGT2A2 4

External Ids for UGT2A1 Gene

Previous GeneCards Identifiers for UGT2A1 Gene

  • GC04P070020
  • GC04M070503
  • GC04M070704
  • GC04M070770
  • GC04M070635
  • GC04M070454

Summaries for UGT2A1 Gene

Entrez Gene Summary for UGT2A1 Gene

  • The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for UGT2A1 Gene

UGT2A1 (UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus) is a Protein Coding gene. Among its related pathways are Porphyrin and chlorophyll metabolism and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2A1 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Gene Wiki entry for UGT2A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2A1 Gene

Genomics for UGT2A1 Gene

Regulatory Elements for UGT2A1 Gene

Enhancers for UGT2A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UGT2A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2A1 Gene

Chromosome:
4
Start:
69,588,417 bp from pter
End:
69,653,249 bp from pter
Size:
64,833 bases
Orientation:
Minus strand

Genomic View for UGT2A1 Gene

Genes around UGT2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2A1 Gene

Proteins for UGT2A1 Gene

  • Protein details for UGT2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X1-UD2A1_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2A1
    Protein Accession:
    Q9Y4X1
    Secondary Accessions:
    • B4E2F4
    • D3GER1
    • D3GER2
    • E9PDM7
    • J3KNA3

    Protein attributes for UGT2A1 Gene

    Size:
    527 amino acids
    Molecular mass:
    59926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2A1 Gene

Proteomics data for UGT2A1 Gene at MOPED

Post-translational modifications for UGT2A1 Gene

  • Glycosylation at Asn 49, Asn 313, and Asn 347
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2A1 Gene

Domains & Families for UGT2A1 Gene

Gene Families for UGT2A1 Gene

Protein Domains for UGT2A1 Gene

Suggested Antigen Peptide Sequences for UGT2A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4X1

UniProtKB/Swiss-Prot:

UD2A1_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2A1: view

Function for UGT2A1 Gene

Molecular function for UGT2A1 Gene

GENATLAS Biochemistry:
UDP glucoronosyltransferase 2 alpha 1,specific for the olfactory tissue
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=75.4 uM for 3-hydroxybiphenyl {ECO:0000269 PubMed:10359671}; KM=59.5 uM for umbelliferone {ECO:0000269 PubMed:10359671}; KM=51.6 uM for S-(-)-b-citronellol {ECO:0000269 PubMed:10359671}; KM=170.1 uM for borneol {ECO:0000269 PubMed:10359671}; KM=56.2 uM for testosterone {ECO:0000269 PubMed:10359671}; KM=251 uM for UDP-glucuronate {ECO:0000269 PubMed:10359671}; Vmax=2.60 nmol/min/mg enzyme with 3-hydroxybiphenyl as substrate {ECO:0000269 PubMed:10359671}; Vmax=0.61 nmol/min/mg enzyme with umbelliferone as substrate {ECO:0000269 PubMed:10359671}; Vmax=1.98 nmol/min/mg enzyme with S-(-)-b-citronellol as substrate {ECO:0000269 PubMed:10359671}; Vmax=1.05 nmol/min/mg enzyme with borneol as substrate {ECO:0000269 PubMed:10359671}; Vmax=0.25 nmol/min/mg enzyme with testosterone as substrate {ECO:0000269 PubMed:10359671};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Enzyme Numbers (IUBMB) for UGT2A1 Gene

Gene Ontology (GO) - Molecular Function for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2A1: view
genes like me logo Genes that share phenotypes with UGT2A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UGT2A1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2A1 Gene

Localization for UGT2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2A1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2A1 Gene COMPARTMENTS Subcellular localization image for UGT2A1 gene
Compartment Confidence
golgi apparatus 3
peroxisome 3
cytoskeleton 1
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT2A1: view

Pathways & Interactions for UGT2A1 Gene

genes like me logo Genes that share pathways with UGT2A1: view

Interacting Proteins for UGT2A1 Gene

Gene Ontology (GO) - Biological Process for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007608 sensory perception of smell IEA --
GO:0009593 detection of chemical stimulus TAS 10359671
GO:0052696 flavonoid glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT2A1: view

No data available for SIGNOR curated interactions for UGT2A1 Gene

Drugs & Compounds for UGT2A1 Gene

(13) Drugs for UGT2A1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 69
Estradiol Approved, Investigational Pharma Sex hormone 1235
Estriol Approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 19
Morphine Approved, Investigational Pharma Full agonist, Agonist 889

(82) Additional Compounds for UGT2A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT2A1: view

Transcripts for UGT2A1 Gene

mRNA/cDNA for UGT2A1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UGT2A1 Gene

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2A1 Gene

No ASD Table

Relevant External Links for UGT2A1 Gene

GeneLoc Exon Structure for
UGT2A1
ECgene alternative splicing isoforms for
UGT2A1

Expression for UGT2A1 Gene

mRNA expression in normal human tissues for UGT2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UGT2A1 Gene

This gene is overexpressed in Nasal epithelium (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for UGT2A1 Gene



SOURCE GeneReport for Unigene cluster for UGT2A1 Gene Hs.225950

mRNA Expression by UniProt/SwissProt for UGT2A1 Gene

Q9Y4X1-UD2A1_HUMAN
Tissue specificity: Olfactory epithelium and brain. Isoform 2 is mainly expressed in the nasal mucosa.
genes like me logo Genes that share expression patterns with UGT2A1: view

Protein tissue co-expression partners for UGT2A1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UGT2A1 Gene

Orthologs for UGT2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ugt2a1 36
  • 88 (a)
OneToMany
Ugt2a1 16
Ugt2a1 35
  • 85.31 (n)
  • 88.54 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 63 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt2a1 35
  • 85.05 (n)
  • 88.16 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11419 35
fruit fly
(Drosophila melanogaster)
Insecta Ugt86Dj 37
  • 35 (a)
Ugt86Di 37
  • 35 (a)
Ugt86Dg 37
  • 35 (a)
Ugt86De 37
  • 34 (a)
Ugt86Dd 37
  • 36 (a)
Ugt86Dc 37
  • 37 (a)
Ugt86Da 37
  • 32 (a)
Ugt37c1 37
  • 30 (a)
Ugt37a1 37
  • 28 (a)
Ugt36Bc 37
  • 27 (a)
Ugt36Bb 37
  • 28 (a)
Ugt36Ba 37
  • 27 (a)
Ugt35b 37
  • 32 (a)
Ugt35a 37
  • 34 (a)
CG6475 37
  • 33 (a)
CG5999 37
  • 31 (a)
CG17323 37
  • 27 (a)
CG10170 37
  • 24 (a)
CG10168 37
  • 25 (a)
BEST:GH09393 37
  • 32 (a)
BEST:GH06505 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea ZC443.5 37
  • 25 (a)
T19H12.11 37
  • 24 (a)
T07C5.1a 37
  • 27 (a)
T03D3.1 37
  • 25 (a)
R04B5.9 37
  • 25 (a)
M88.1 37
  • 32 (a)
F56B3.7 37
  • 27 (a)
F47C10.6 37
  • 24 (a)
F39G3.1 37
  • 32 (a)
F35H8.6 37
  • 27 (a)
F01D4.2 37
  • 23 (a)
F01D4.1 37
  • 24 (a)
C44H9.1 37
  • 27 (a)
C33A12.6 37
  • 26 (a)
C17G1.3 37
  • 28 (a)
C10H11.5 37
  • 25 (a)
C10H11.4 37
  • 25 (a)
C08B6.1 37
  • 23 (a)
C03A7.11 37
  • 23 (a)
AC3.2 37
  • 27 (a)
Species with no ortholog for UGT2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT2A1 Gene

ENSEMBL:
Gene Tree for UGT2A1 (if available)
TreeFam:
Gene Tree for UGT2A1 (if available)

Paralogs for UGT2A1 Gene

genes like me logo Genes that share paralogs with UGT2A1: view

Variants for UGT2A1 Gene

Sequence variations from dbSNP and Humsavar for UGT2A1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_024686 -
VAR_057326 -
rs1347046 - 69,647,421(-) ATATA(A/G)GGTGC reference, missense
rs979363 -- 69,652,994(+) TTATT(C/T)TGAAG intron-variant
rs1368116 -- 69,649,705(-) ACAGC(A/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2A1 Gene

Variant ID Type Subtype PubMed ID
nsv510892 CNV Complex 20534489
nsv879444 CNV Loss 21882294
nsv4377 CNV Loss 18451855
esv33983 CNV Gain+Loss 17666407
esv1001272 CNV Deletion 20482838
esv24189 CNV Loss 19812545
dgv93n16 CNV Deletion 17901297
esv2658506 CNV Deletion 23128226
nsv499046 CNV Loss 21111241
nsv514225 CNV Loss 21397061
nsv822601 CNV Loss 20364138
nsv511264 CNV Loss 21212237
dgv5625n71 CNV Loss 21882294
nsv879446 CNV Loss 21882294
nsv521416 CNV Loss 19592680
dgv659n27 CNV Loss 19166990
nsv461552 CNV Loss 19166990
nsv292823 CNV Loss 16902084
nsv879448 CNV Gain 21882294
nsv879449 CNV Loss 21882294

Variation tolerance for UGT2A1 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2A1 Gene

HapMap Linkage Disequilibrium report
UGT2A1
Human Gene Mutation Database (HGMD)
UGT2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2A1 Gene

Disorders for UGT2A1 Gene

Relevant External Links for UGT2A1

Genetic Association Database (GAD)
UGT2A1
Human Genome Epidemiology (HuGE) Navigator
UGT2A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2A1

No disorders were found for UGT2A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2A1 Gene

Publications for UGT2A1 Gene

  1. Cloning and characterization of a novel human olfactory UDP- glucuronosyltransferase. (PMID: 10359671) Jedlitschky G.A. … Burchell B. (Biochem. J. 1999) 2 3 4 67
  2. A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes. (PMID: 23551063) Rahikainen T. … Juvonen R.O. (Xenobiotica 2013) 3
  3. The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation. (PMID: 23756265) Perreault M. … Barbier O. (Drug Metab. Dispos. 2013) 3
  4. Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent. (PMID: 23372764) Manevski N. … Finel M. (PLoS ONE 2013) 3
  5. Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases. (PMID: 22265884) Zhang H. … Finel M. (Toxicol In Vitro 2012) 3

Products for UGT2A1 Gene

Sources for UGT2A1 Gene

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