Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UGT1A9 Gene

protein-coding   GIFtS: 55
GCID: GC02P234580

UDP Glucuronosyltransferase 1 Family, Polypeptide A9

(Previous names: UDP glycosyltransferase 1 family, polypeptide A9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A91 2     HLUGP42
UDP Glycosyltransferase 1 Family, Polypeptide A91 2     LUGP42
UGT-1I2 3     UDPGT2
UGT1-092 3     UGT1-92
UGT1.92 3     UGT1AI2
UGT1I2 3     UDP-Glucuronosyltransferase 1-92
UDP-Glucuronosyltransferase 1-I2 3     GNT13
UDP-Glucuronosyltransferase 1A92 3     UGT13
UDPGT 1-92 3     UGT1*93
EC 2.4.1.173 8     lugP43

External Ids:    HGNC: 125411   Entrez Gene: 546002   Ensembl: ENSG000002411197   OMIM: 6064345   UniProtKB: O606563   

Export aliases for UGT1A9 gene to outside databases

Previous GC identifers: GC02U990251 GC02P234822 GC02P234885 GC02P234369 GC02P234370 GC02P234200 GC02P234210 GC02P234220 GC02P234245 GC02P226380


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UGT1A9 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on
phenols. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A9 Gene:
UGT1A9 (UDP glucuronosyltransferase 1 family, polypeptide A9) is a protein-coding gene. Diseases associated with UGT1A9 include crigler-najjar syndrome, and crigler najjar syndrome, type 2. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds. This isoform has specificity for phenols

Gene Wiki entry for UGT1A9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the UGT1A9 gene promoter:
         COUP-TF1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UGT1A9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT1A9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A9 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234580:  view genomic region     (about GC identifiers)

Start:
234,580,499 bp from pter      End:
234,681,951 bp from pter
Size:
101,453 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UD19_HUMAN, O60656 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-9 precursor  
Size: 530 amino acids; 59941 Da
Sequence caution: Sequence=AAB19791.2; Type=Frameshift; Positions=59, 82;
Secondary accessions: P36509 Q9HAX0
Alternative splicing: 1 isoform:  O60656-1   

Explore the universe of human proteins at neXtProt for UGT1A9: NX_O60656

Explore proteomics data for UGT1A9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn292, Asn344
  • Selected DME Specific Peptides for UGT1A9 (O60656) (see all 24)
     PEVSWQL  FWVEFVM  WLLRTDF  QYHSLDV 


    See UGT1A9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066307.1  
    ENSEMBL proteins: 
     ENSP00000346768  
    Reactome Protein details: O60656

    UGT1A9 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UGT1A9
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UGT1A9
    GenScript Custom Purified and Recombinant Proteins Services for UGT1A9
    Novus Biologicals UGT1A9 Proteins
    Novus Biologicals UGT1A9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UGT1A9

    UGT1A9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UGT1A9
    OriGene Custom Antibody Services for UGT1A9
    Novus Biologicals UGT1A9 Antibodies
    Abcam antibodies for UGT1A9
    Cloud-Clone Corp. Antibodies for UGT1A9
    ThermoFisher Antibody for UGT1A9
    LSBio Antibodies in human, mouse, rat for UGT1A9

    UGT1A9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UGT1A9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UGT1A9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UGT1A9
    Cloud-Clone Corp. CLIAs for UGT1A9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry O60656

    ProtoNet protein and cluster: O60656

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT1A9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD19_HUMAN, O60656
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds. This isoform has specificity for phenols
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA--
    GO:0004857enzyme inhibitor activity IDA--
    GO:0015020glucuronosyltransferase activity IDA18052087
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0019899enzyme binding IDA--
         
    UGT1A9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT1A9:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT1A9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGT1A9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGT1A9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGT1A9

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UGT1A9 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate UGT1A9:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UGT1A9
    Predesigned siRNA for gene silencing in human, mouse, rat UGT1A9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UGT1A9

    Clone
    Products:
         
    OriGene clones in human, mouse for UGT1A9 (see all 7)
    OriGene ORF clones in mouse, rat for UGT1A9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UGT1A9 (NM_021027)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT1A9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A9

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UGT1A9
    Browse ESI BIO Cell Lines and PureStem Progenitors for UGT1A9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UD19_HUMAN, O60656: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    extracellular2
    golgi apparatus2
    nucleus2
    peroxisome2
    lysosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    UGT1A9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UGT1A9 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Phenytoin Pathway, Pharmacokinetics0.00
    Phase II conjugation0.56
    Sorafenib Pharmacokinetics0.00
    metapathway biotransformation0.42
    Glucuronidation0.00
    Benzodiazepine Pathway, Pharmacokinetics0.00
    Acetaminophen metabolism0.00
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Arylamine metabolism0.00
    Metabolism of xenobiotics by cytochrome P4500.71
    Benzo a pyrene metabolism0.00
    Drug metabolism - cytochrome P4500.69
    Artemisinin and Derivatives Pathway, Pharmacokinetics0.00
    Retinol metabolism0.35
    3Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    4Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    5Metabolism of porphyrins
    Metabolism of porphyrins0.56
    Heme degradation0.00
    Porphyrin and chlorophyll metabolism0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for UGT1A9
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Benzo[a]pyrene metabolism
    Acetaminophen metabolism

    Selected BioSystems Pathways for UGT1A9 (see all 6)
        Glucuronidation
    Irinotecan Pathway
    Arylamine metabolism
    Estrogen metabolism
    Nicotine metabolism

    2 Reactome Pathways for UGT1A9
        PPARA activates gene expression
    Glucuronidation

    Selected PharmGKB Pathways for UGT1A9 (see all 12)
        Acetaminophen Pathway, Pharmacokinetics
    Artemisinin and Derivatives Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Ibuprofen Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for UGT1A9) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT1A9 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UGT1A9: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UGT1A9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT1A9 (ENSP000003467684) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH6ENSP000003783594STRING: ENSP00000378359
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006805xenobiotic metabolic process IDA1910331
    GO:0008152metabolic process TAS1910331
    GO:0017144drug metabolic process IDA--
    GO:0030259lipid glycosylation ----

    UGT1A9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT1A9 (UD19)

    Selected HMDB Compounds for UGT1A9 (see all 87)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-715843492
    Acetaminophen glucuronide4-acetamidophenyl b-D-glucopyranosiduronic acid (see all 8)16110-10-411714888
    Ethyl glucuronide 17685-04-016139098
    Hydroxycotinine(3R-trans)-3-hydroxy-1-methyl-5-(3-pyridinyl)-2-Pyrrolidinone (see all 5)34834-67-815470160
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-315843492
    Nicotine glucuronide(S)-1-alpha-D-glucopyranuronosyl-3-(1-methyl-2-pyrrolidinyl)-Pyridinium inner salt (see all 11)152306-59-714570768
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    Valproic acid glucuronide1-(2-propylpentanoate) beta-D-Glucopyranuronate (see all 18)60113-83-912732356
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-Salicylate glucuronide1-salicylic acid glucuronide ----

    Selected DrugBank Compounds for UGT1A9 (see all 30)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EntacaponeEntacapona [INN-Spanish] (see all 3)130929-57-6enzymesubstrate12435745 15802387 11038168
    Sorafenib-- 284461-73-0enzymesubstrate inhibitor20706860 19228077 19733976
    Mycophenolic acid-- 24280-93-1enzymesubstrate21123165 15470161
    Propofol2,6-Diisopropylphenol (see all 2)2078-54-8enzymesubstrate18816295 19515014
    Troglitazone-- 97322-87-7enzymesubstrate12433820 12582161
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate11714888
    BuprenorphineBuprenophine (see all 3)52485-79-7enzymesubstrate19515014
    Dabigatran etexilateDabigatran (see all 2)211915-06-9enzymesubstrate20551237
    Etodolac-- 41340-25-4enzymesubstrate19515014
    Ezogabine D-23129 (see all 5)150812-12-7enzymesubstrate10220490

    Selected Novoseek inferred chemical compound relationships for UGT1A9 gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-hydroxy-n'-acetylbenzidine 84.5 1 10506112 (1)
    sn38 glucuronide 82.5 2 12944498 (1), 16595709 (1)
    glucuronide 81.7 6 9762354 (1), 17359941 (1), 12582161 (1), 10051052 (1) (see all 6)
    uridine diphosphate 81.7 4 17924828 (1), 12201491 (1), 19644937 (1), 18816295 (1)
    mycophenolic acid 80.2 58 17529886 (4), 17924828 (4), 16198654 (3), 17339869 (3) (see all 16)
    sn 38 79.7 8 12944498 (2), 16595709 (2), 20196838 (1)
    n-acetylbenzidine 76.7 1 10506112 (1)
    n-hydroxy phip 76.1 5 11375903 (1), 11408353 (1)
    4-methylumbelliferone 70.3 7 10220484 (1), 16545899 (1), 16278927 (1), 19850672 (1) (see all 5)
    irinotecan 70.1 13 15709193 (2), 12944498 (2), 15864130 (2), 12730278 (1) (see all 10)

    3 PharmGKB related drug/compound annotations for UGT1A9 gene    About this table
    Drug/compound PharmGKB Annotation
    mycophenolate mofetilCA  
    propofolCA  
    valproic acidCA  



    UGT1A9 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UGT1A9 gene: 
    NM_021027.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000354728(uc010zmw.1 uc002vus.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UGT1A9 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate UGT1A9:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UGT1A9
    Predesigned siRNA for gene silencing in human, mouse, rat UGT1A9
    Clone
    Products:
         
    OriGene clones in human, mouse for UGT1A9 (see all 7)
    OriGene ORF clones in mouse, rat for UGT1A9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UGT1A9 (NM_021027)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT1A9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A9
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UGT1A9
    OriGene qSTAR qPCR primer pairs in human, mouse for UGT1A9
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UGT1A9
      QuantiTect SYBR Green Assays in human, mouse, rat UGT1A9
      QuantiFast Probe-based Assays in human, mouse, rat UGT1A9

    Selected AceView cDNA sequences (see all 271):

    NM_021027 AI566081 AI701383 AI479279 BE464422 BE464186 AI767337 NM_001072 
    AY435142 AI795931 NM_019076 CB162031 BE463503 AY435144 AV660038 AV646429 
    NM_019078 CB163625 NM_205862 BE464379 AY435136 NM_019093 AV650286 AY435140 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UGT1A9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A9 Expression
    About this image

    UGT1A9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT1A9 Protein Expression

    UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
    Tissue specificity: Liver

        Pathway & Disease-focused RT2 Profiler PCR Array including UGT1A9: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UGT1A9
    OriGene qSTAR qPCR primer pairs in human, mouse for UGT1A9
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UGT1A9
    QuantiTect SYBR Green Assays in human, mouse, rat UGT1A9
    QuantiFast Probe-based Assays in human, mouse, rat UGT1A9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A9 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a91 , 5 UDP glucuronosyltransferase 1 family, polypeptide A91, 5 81.11(n)1
    80.59(a)1
      1 (44.50 cM)5
    3944341  NM_201644.21  NP_964006.21 
     880708005 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    60(a)
    44(a)
    many ↔ many
    many ↔ many
    7(5735050-5897491)
    7(5872756-5873724)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    many ↔ many
    6(58602730-58619079)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1a76
    ugt1b16
    (see all 6)
    UDP glucuronosyltransferase 1 family, polypeptide ...
    UDP glucuronosyltransferase 1 family, polypeptide ...
    (see all 6)
    50(a)
    46(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    9(10194767-10228491) ENSDARG00000006220
    11(31196570-31204509) ENSDARG00000097491


    ENSEMBL Gene Tree for UGT1A9 (if available)
    TreeFam Gene Tree for UGT1A9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UGT1A9 gene
    UGT1A81 2  UGT1A71 2  UGT1A101 2  UGT2A22  UGT3A12  UGT2B112  UGT2B72  UGT1A32  
    UGT1A12  UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A62  UGT82  UGT2B152  
    UGT2B42  UGT2A32  UGT2B172  UGT2B282  UGT1A42  
    Selected SIMAP similar genes for UGT1A9 using alignment to 8 protein entries:     UD19_HUMAN (see all proteins) (see all similar genes):
    UGT1A9S    UGT1A8S    UGT1A10    UGT1J    UGT1A8    UGT1A3S
    UGT1H    UGT1A7    UGT1G    UGT1A6    BILIQTL1    UGT1A1
    UGT1A6S    UGT1    UGT1A4S    UGT2A3    UGT1A4    UGT1A3

    UGT1A9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UGT1A9
    PGOHUM00000241147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    2 SNPs for UGT1A9    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360354
    A breast cancer sample4--see VAR_0360352 S I mis40--------
    rs725513301,2,4
    ----see VAR_0585872 mis40--------

    HapMap Linkage Disequilibrium report for UGT1A9 (234580499 - 234681951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGT1A9 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2661542CNV Deletion23128226
    esv2721664CNV Deletion23290073
    esv2721667CNV Deletion23290073
    esv2721666CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721669CNV Deletion23290073
    esv2721668CNV Deletion23290073
    nsv514125CNV Loss21397061
    nsv433211CNV Loss18776910

    Human Gene Mutation Database (HGMD): UGT1A9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT1A9
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606434    OMIM disorders: --

    Selected diseases for UGT1A9 (see all 25):    
    About MalaCards
    crigler-najjar syndrome    crigler najjar syndrome, type 2    kernicterus    gilbert syndrome
    bilirubin metabolic disorder    neonatal jaundice    sickle cell anemia    cholelithiasis
    kawasaki disease    neutropenia    hepatitis c    attention deficit hyperactivity disorder
    colorectal cancer    hepatitis    hepatocellular carcinoma    breast and colorectal cancer
    liver disease    pancreatic cancer    breast cancer    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for UGT1A9:
    Bilirubin metabolic disorder     Kernicterus

    UGT1A9 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for UGT1A9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis autoimmune 21.8 1 11343231 (1)
    cancer 13.8 6 12730278 (2), 17406868 (2), 17700594 (1), 16595709 (1)
    colorectal cancer 7.4 2 15709193 (1), 19364970 (1)
    colon carcinoma 6.96 1 10220484 (1)
    breast cancer 0 1 18430559 (1)
    hepatocellular carcinoma 0 1 11677206 (1)
    hepatitis c 0 1 11343231 (1)

    Genetic Association Database (GAD): UGT1A9
    Human Genome Epidemiology (HuGE) Navigator: UGT1A9 (53 documents)

    Export disorders for UGT1A9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UGT1A9 gene, integrated from 10 sources (see all 253):
    (articles sorted by number of sources associating them with UGT1A9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9). (PubMed id 18816295)1, 4, 7, 9 Takahashi H....Takeuchi Y. (amp 2008)
    2. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)1, 2, 4, 9 Menard V.... Guillemette C. (Hum. Mutat. 2009)
    3. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family. (PubMed id 1910331)1, 2, 3 Wooster R....Burchell B. (Biochem. J. 1991)
    4. Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. (PubMed id 15284532)1, 4, 9 Girard H.... Guillemette C. (Pharmacogenetics 2004)
    5. N-Glycosylation plays a role in protein folding of human UGT1A9. (PubMed id 19951703)1, 2, 9 Nakajima M.... Yokoi T. (Biochem. Pharmacol. 2010)
    6. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer. (PubMed id 17406868)1, 4, 9 Fujita K....Sasaki Y. (Cancer Chemother. Pharmacol. 2007)
    7. Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations. (PubMed id 17115150)1, 4, 9 Mehlotra R.K....Zimmerman P.A. (Eur. J. Clin. Pharmacol. 2007)
    8. Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. (PubMed id 11714888)6, 7, 9 Court M.H....Mackenzie P.I. (J. Pharmacol. Exp. Ther. 2001)
    9. Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. (PubMed id 17529886)1, 4, 9 Inoue K....Suzuki T. (Ther Drug Monit 2007)
    10. The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients. (PubMed id 16198654)1, 4, 9 Kuypers D.R....Vanrenterghem Y. (Clin. Pharmacol. Ther. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54600 HGNC: 12541 AceView: UGT1A1 Ensembl:ENSG00000241119 euGenes: HUgn54600
    ECgene: UGT1A9 Kegg: 54600 H-InvDB: UGT1A9

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UGT1A9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UGT1A9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UGT1A9 gene:
    Search GeneIP for patents involving UGT1A9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UGT1A9   OriGene RNAi products in human, mouse, rat for UGT1A9  
     OriGene qPCR primer pairs and template standards for UGT1A9   OriGene Protein Over-expression Lysate for UGT1A9  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UGT1A9  
     OriGene qSTAR qPCR primer pairs in human, mouse for UGT1A9   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UGT1A9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UGT1A9   OriGene Custom Protein Services for UGT1A9  

     
     
     Block miRNA regulation of human, mouse, rat UGT1A9 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UGT1A9
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT1A9 Predesigned siRNA for gene silencing in human, mouse, rat UGT1A9
     QuantiFast Probe-based Assays in human, mouse, rat UGT1A9 QuantiTect SYBR Green Assays in human, mouse, rat UGT1A9
     PCR Arrays including human, mouse, rat UGT1A9 Search Chromatin IP Primers for UGT1A9
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UGT1A9  GeneGlobe Interaction Network for UGT1A9
     Regulatory tfbs in UGT1A9 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UGT1A9 GenScript cDNA clones with any tag delivered in your preferred vector for UGT1A9
     GenScript Custom Assay Services for UGT1A9 GenScript Custom overexpressing Cell Line Services for UGT1A9
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UGT1A9 (UD19)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UGT1A9 antibodies
     UGT1A9 proteins
     UGT1A9 lysates
     Antibodies for UGT1A9
     See all of Abcam's Antibodies, Kits and Proteins for UGT1A9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UGT1A9
     Antibodies for UGT1A9
     ELISAs for UGT1A9
     CLIAs for UGT1A9



     Browse ESI BIO Cell Lines and PureStem Progenitors for UGT1A9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A9
     Browse SwitchGear 3'UTR luciferase reporter plasmids for UGT1A9
     Browse SwitchGear Promoter luciferase reporter plasmids for UGT1A9
     ThermoFisher Antibody for UGT1A9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A9
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT1A9
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGT1A9
     LSBio Antibodies in human, mouse, rat for UGT1A9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UGT1A9 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4