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Aliases for UGT1A9 Gene

Aliases for UGT1A9 Gene

  • UDP Glucuronosyltransferase 1 Family, Polypeptide A9 2 3
  • UDP Glycosyltransferase 1 Family, Polypeptide A9 2 3
  • UDP-Glucuronosyltransferase 1-I 3 4
  • UDP-Glucuronosyltransferase 1A9 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 1-9 3 4
  • UGT1-09 3 4
  • UGT-1I 3 4
  • UGT1.9 3 4
  • LUGP4 3 4
  • UGT1I 3 4
  • UDP-Glucuronosyltransferase 1-9 3
  • HLUGP4 3
  • UGT1-9 3
  • UGT1AI 3
  • UGT1*9 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A9 Gene

Summaries for UGT1A9 Gene

Entrez Gene Summary for UGT1A9 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A9 Gene

UGT1A9 (UDP Glucuronosyltransferase 1 Family, Polypeptide A9) is a Protein Coding gene. Diseases associated with UGT1A9 include gilbert syndrome and crigler-najjar syndrome, type i. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT1A9 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A9 Gene

Genomics for UGT1A9 Gene

Genomic Location for UGT1A9 Gene

Start:
233,671,853 bp from pter
End:
233,773,305 bp from pter
Size:
101,453 bases
Orientation:
Plus strand

Genomic View for UGT1A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT1A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A9 Gene

Regulatory Elements for UGT1A9 Gene

Proteins for UGT1A9 Gene

  • Protein details for UGT1A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60656-UD19_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-9
    Protein Accession:
    O60656
    Secondary Accessions:
    • B8K285
    • P36509
    • Q9HAX0

    Protein attributes for UGT1A9 Gene

    Size:
    530 amino acids
    Molecular mass:
    59941 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity
    SequenceCaution:
    • Sequence=AAB19791.2; Type=Frameshift; Positions=59, 82; Evidence={ECO:0000305};

    Alternative splice isoforms for UGT1A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A9 Gene

Proteomics data for UGT1A9 Gene at MOPED

Post-translational modifications for UGT1A9 Gene

  • Glycosylation at Asn71, Asn292, and Asn344

Other Protein References for UGT1A9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UGT1A9 Gene

Gene Families for UGT1A9 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT1A9 Gene

Graphical View of Domain Structure for InterPro Entry

O60656

UniProtKB/Swiss-Prot:

UD19_HUMAN
Family:
  • Belongs to the UDP-glycosyltransferase family.:
    • O60656
genes like me logo Genes that share domains with UGT1A9: view

Function for UGT1A9 Gene

Molecular function for UGT1A9 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A9 Gene

Gene Ontology (GO) - Molecular Function for UGT1A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
GO:0004857 enzyme inhibitor activity IGI 20610558
GO:0015020 glucuronosyltransferase activity ISS 20610558
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0019899 enzyme binding IPI 20610558
genes like me logo Genes that share ontologies with UGT1A9: view

Phenotypes for UGT1A9 Gene

GenomeRNAi human phenotypes for UGT1A9:
genes like me logo Genes that share phenotypes with UGT1A9: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT1A9 Gene

Localization for UGT1A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A9 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A9 Gene COMPARTMENTS Subcellular localization image for UGT1A9 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
extracellular 2
golgi apparatus 2
nucleus 2
peroxisome 2
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT1A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum NAS 20610558
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UGT1A9: view

Pathways for UGT1A9 Gene

genes like me logo Genes that share pathways with UGT1A9: view

Interacting Proteins for UGT1A9 Gene

Gene Ontology (GO) - Biological Process for UGT1A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006805 xenobiotic metabolic process IDA 1910331
GO:0008152 metabolic process TAS 1910331
GO:0009813 flavonoid biosynthetic process IBA --
GO:0017144 NOT drug metabolic process IDA 20610558
genes like me logo Genes that share ontologies with UGT1A9: view

Compounds for UGT1A9 Gene

(87) HMDB Compounds for UGT1A9 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available

(30) Drugbank Compounds for UGT1A9 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acetaminophen
  • Acetaminofen
103-90-2 enzyme substrate
Buprenorphine
  • Buprenophine
52485-79-7 enzyme substrate
Canagliflozin
842133-18-0 enzyme substrate
Dabigatran etexilate
  • Dabigatran
211915-06-9 enzyme substrate
Entacapone
  • Entacapona [INN-Spanish]
130929-57-6 enzyme substrate

(38) Novoseek inferred chemical compound relationships for UGT1A9 Gene

Compound -log(P) Hits PubMed IDs
n-hydroxy-n-acetylbenzidine 84.5 1
sn38 glucuronide 82.5 2
glucuronide 81.7 6
uridine diphosphate 81.7 4
mycophenolic acid 80.2 31

(8) PharmGKB related drug/compound annotations for UGT1A9 Gene

genes like me logo Genes that share compounds with UGT1A9: view

Transcripts for UGT1A9 Gene

mRNA/cDNA for UGT1A9 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A9 Gene

No ASD Table

Relevant External Links for UGT1A9 Gene

GeneLoc Exon Structure for
UGT1A9
ECgene alternative splicing isoforms for
UGT1A9

Expression for UGT1A9 Gene

mRNA expression in normal human tissues for UGT1A9 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A9 Gene

This gene is overexpressed in Kidney - Cortex (41.9) and Liver (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UGT1A9 Gene

mRNA Expression by UniProt/SwissProt for UGT1A9 Gene

O60656-UD19_HUMAN
Tissue specificity: Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine.
genes like me logo Genes that share expressions with UGT1A9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UGT1A9 Gene

Orthologs for UGT1A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT1A9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ugt1a10 36
  • 79 (a)
ManyToMany
Ugt1a7c 36
  • 79 (a)
ManyToMany
Ugt1a8 36
  • 78 (a)
ManyToMany
Ugt1a9 35
  • 81.11 (n)
  • 80.59 (a)
Ugt1a9 16
Ugt1a9 36
  • 79 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ugt1a8 35
  • 82.09 (n)
  • 80.39 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 60 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ugt1a7 36
  • 50 (a)
ManyToMany
ugt1b1 36
  • 46 (a)
ManyToMany
ugt1b2 36
  • 45 (a)
ManyToMany
ugt1b3 36
  • 45 (a)
ManyToMany
ugt1b4 36
  • 46 (a)
ManyToMany
ugt1b5 36
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10178 37
  • 27 (a)
BEST:GH09393 37
  • 29 (a)
Ugt86Da 37
  • 33 (a)
Dot 37
  • 26 (a)
CG16732 37
  • 24 (a)
CG10168 37
  • 29 (a)
Ugt36Bb 37
  • 30 (a)
Ugt86De 37
  • 30 (a)
CG11289 37
  • 35 (a)
CG10170 37
  • 25 (a)
CG5999 37
  • 26 (a)
Ugt86Di 37
  • 32 (a)
Ugt37c1 37
  • 30 (a)
CG15661 37
  • 32 (a)
Ugt86Dh 37
  • 27 (a)
Ugt36Ba 37
  • 29 (a)
Ugt37b1 37
  • 27 (a)
BEST:GH06505 37
  • 28 (a)
Ugt86Dc 37
  • 34 (a)
CG5724 37
  • 27 (a)
Ugt37a1 37
  • 27 (a)
CG6475 37
  • 32 (a)
CG17323 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea F56B3.7 37
  • 25 (a)
C08F11.8 37
  • 26 (a)
C17G1.3 37
  • 26 (a)
Y37E11AR.5 37
  • 27 (a)
C49A9.8 37
  • 24 (a)
ZC443.5 37
  • 27 (a)
C10H11.6 37
  • 24 (a)
C08B6.1 37
  • 25 (a)
F35H8.6 37
  • 29 (a)
F09G2.6 37
  • 24 (a)
K08B4.4 37
  • 24 (a)
F01D4.2 37
  • 22 (a)
R04B5.9 37
  • 23 (a)
AC3.2 37
  • 25 (a)
AC3.7 37
  • 25 (a)
ZC455.3 37
  • 22 (a)
C44H9.1 37
  • 25 (a)
T01G5.2 37
  • 24 (a)
C10H11.4 37
  • 25 (a)
AC3.8 37
  • 21 (a)
C33A12.6 37
  • 25 (a)
F39G3.1 37
  • 29 (a)
M88.1 37
  • 29 (a)
C10H11.5 37
  • 26 (a)
F01D4.1 37
  • 23 (a)
Species with no ortholog for UGT1A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT1A9 Gene

ENSEMBL:
Gene Tree for UGT1A9 (if available)
TreeFam:
Gene Tree for UGT1A9 (if available)

Paralogs for UGT1A9 Gene

Pseudogenes.org Pseudogenes for UGT1A9 Gene

genes like me logo Genes that share paralogs with UGT1A9: view

Variants for UGT1A9 Gene

Sequence variations from dbSNP and Humsavar for UGT1A9 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_036035 A breast cancer sample
VAR_058587 -

Structural Variations from Database of Genomic Variants (DGV) for UGT1A9 Gene

Variant ID Type Subtype PubMed ID
esv2721664 CNV Deletion 23290073
esv2721666 CNV Deletion 23290073
nsv876016 CNV Gain 21882294
nsv876017 CNV Loss 21882294
esv2721667 CNV Deletion 23290073
nsv3215 CNV Loss 18451855
esv2721668 CNV Deletion 23290073
esv2661542 CNV Deletion 23128226
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061
esv8142 CNV Loss 19470904
esv2721669 CNV Deletion 23290073
nsv876018 CNV Gain 21882294

Relevant External Links for UGT1A9 Gene

HapMap Linkage Disequilibrium report
UGT1A9
Human Gene Mutation Database (HGMD)
UGT1A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A9 Gene

Disorders for UGT1A9 Gene

(2) University of Copenhagen DISEASES for UGT1A9 Gene

(7) Novoseek inferred disease relationships for UGT1A9 Gene

Disease -log(P) Hits PubMed IDs
hepatitis autoimmune 21.8 1
cancer 13.8 6
colorectal cancer 7.4 2
colon carcinoma 6.96 1
breast cancer 0 1

Relevant External Links for UGT1A9

Genetic Association Database (GAD)
UGT1A9
Human Genome Epidemiology (HuGE) Navigator
UGT1A9
genes like me logo Genes that share disorders with UGT1A9: view

No data available for UniProtKB/Swiss-Prot for UGT1A9 Gene

Publications for UGT1A9 Gene

  1. Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9). (PMID: 18816295) Takahashi H. … Takeuchi Y. (Basic Clin. Pharmacol. Toxicol. 2008) 3 23 25 48
  2. Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. (PMID: 11677206) Vogel A. … Strassburg C.P. (Gastroenterology 2001) 3 23 48
  3. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. (PMID: 15057901) Ehmer U. … Strassburg C.P. (Hepatology 2004) 3 23 48
  4. A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity. (PMID: 15115919) Yamanaka H. … Yokoi T. (Pharmacogenetics 2004) 3 23 48
  5. Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. (PMID: 15284532) Girard H. … Guillemette C. (Pharmacogenetics 2004) 3 23 48

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