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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT1A9 Gene

protein-coding   GIFtS: 56
GCID: GC02P234580

UDP Glucuronosyltransferase 1 Family, Polypeptide A9

(Previous names: UDP glycosyltransferase 1 family, polypeptide A9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A91 2     HLUGP42
UDP Glycosyltransferase 1 Family, Polypeptide A91 2     LUGP42
UGT-1I2 3     UDPGT2
UGT1-092 3     UGT1-92
UGT1.92 3     UGT1AI2
UGT1I2 3     UDP-Glucuronosyltransferase 1-92
UDP-Glucuronosyltransferase 1-I2 3     GNT13
UDP-Glucuronosyltransferase 1A92 3     UGT13
UDPGT 1-92 3     UGT1*93
EC 2.4.1.173 8     lugP43

External Ids:    HGNC: 125411   Entrez Gene: 546002   Ensembl: ENSG000002411197   OMIM: 6064345   UniProtKB: O606563   

Export aliases for UGT1A9 gene to outside databases

Previous GC identifers: GC02U990251 GC02P234822 GC02P234885 GC02P234369 GC02P234370 GC02P234200 GC02P234210 GC02P234220 GC02P234245 GC02P226380


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGT1A9 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on
phenols. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A9 Gene: 
UGT1A9 (UDP glucuronosyltransferase 1 family, polypeptide A9) is a protein-coding gene. Diseases associated with UGT1A9 include crigler-najjar syndrome, and crigler najjar syndrome, type 2, and among its related super-pathways are Ascorbate and aldarate metabolism and Irinotecan Pathway, Pharmacokinetics. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds. This isoform has specificity for phenols

Gene Wiki entry for UGT1A9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT1A9 gene promoter:
         COUP-TF1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UGT1A9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A9 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234580:  view genomic region     (about GC identifiers)

Start:
234,580,499 bp from pter      End:
234,681,951 bp from pter
Size:
101,453 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UD19_HUMAN, O60656 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-9 precursor  
Size: 530 amino acids; 59941 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAB19791.2; Type=Frameshift; Positions=59, 82;
Secondary accessions: P36509 Q9HAX0
Alternative splicing: 1 isoform:  O60656-1   

Explore the universe of human proteins at neXtProt for UGT1A9: NX_O60656

Explore proteomics data for UGT1A9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60656

  • 4/24 DME Specific Peptides for UGT1A9 (O60656) (see all 24)
     PEVSWQL  FWVEFVM  WLLRTDF  QYHSLDV 

    UGT1A9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGT1A9 Protein Expression
    REFSEQ proteins: NP_066307.1  
    ENSEMBL proteins: 
     ENSP00000346768  
    Reactome Protein details: O60656
    Human Recombinant Protein Products for UGT1A9: 
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    Cloud-Clone Corp. Proteins for UGT1A9 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0043231intracellular membrane-bounded organelle NAS--

    UGT1A9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry O60656

    ProtoNet protein and cluster: O60656

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT1A9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD19_HUMAN, O60656
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds. This isoform has specificity for phenols
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA--
    GO:0004857enzyme inhibitor activity IDA--
    GO:0015020glucuronosyltransferase activity IDA18052087
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0019899enzyme binding IDA--
         
    UGT1A9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT1A9:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UGT1A9 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.67
    Starch and sucrose metabolism0.41
    Glucuronidation0.67
    Porphyrin and chlorophyll metabolism0.38
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.33
    Pentose and glucuronate interconversions0.61
    Steroid hormone biosynthesis0.30
    2Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    3Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    4Acetaminophen metabolism
    Acetaminophen metabolism0.43
    2-Naphthylamine and 2-Nitronaphtalene metabolism0.32
    Acetaminophen Pathway, Pharmacokinetics0.43
    5Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for UGT1A9
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Acetaminophen metabolism
    Benzo[a]pyrene metabolism


    3 GeneGo (Thomson Reuters) Pathways for UGT1A9
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Benzo[a]pyrene metabolism
    Acetaminophen metabolism

    5/6 BioSystems Pathways for UGT1A9 (see all 6)
        Glucuronidation
    Irinotecan Pathway
    Arylamine metabolism
    Estrogen metabolism
    Nicotine metabolism

    5/8        Reactome Pathways for UGT1A9 (see all 8)
        Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    Glucuronidation
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    PPARA Activates Gene Expression

    5/12 PharmGKB Pathways for UGT1A9 (see all 12)
        Acetaminophen Pathway, Pharmacokinetics
    Artemisinin and Derivatives Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Ibuprofen Pathway, Pharmacokinetics

    5/11         Kegg Pathways  (Kegg details for UGT1A9) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT1A9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT1A9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT1A9 (ENSP000003467684) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    BLVRAENSP000002655234STRING: ENSP00000265523
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006805xenobiotic metabolic process IDA1910331
    GO:0008152metabolic process NAS--
    GO:0017144drug metabolic process IDA--
    GO:0030259lipid glycosylation ----

    UGT1A9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT1A9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT1A9 (UD19)

    10/87 HMDB Compounds for UGT1A9 (see all 87)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-715843492
    Acetaminophen glucuronide4-acetamidophenyl b-D-glucopyranosiduronic acid (see all 8)16110-10-411714888
    Ethyl glucuronide 17685-04-016139098
    Hydroxycotinine(3R-trans)-3-hydroxy-1-methyl-5-(3-pyridinyl)-2-Pyrrolidinone (see all 5)34834-67-815470160
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-315843492
    Nicotine glucuronide(S)-1-alpha-D-glucopyranuronosyl-3-(1-methyl-2-pyrrolidinyl)-Pyridinium inner salt (see all 11)152306-59-714570768
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    Valproic acid glucuronide1-(2-propylpentanoate) beta-D-Glucopyranuronate (see all 18)60113-83-912732356
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-Salicylate glucuronide1-salicylic acid glucuronide ----

    10/30 DrugBank Compounds for UGT1A9 (see all 30)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EntacaponeEntacapona [INN-Spanish] (see all 3)130929-57-6enzymesubstrate12435745 15802387 11038168
    Sorafenib-- 284461-73-0enzymesubstrate inhibitor20706860 19228077 19733976
    Mycophenolic acid-- 24280-93-1enzymesubstrate21123165 15470161
    Propofol2,6-Diisopropylphenol (see all 2)2078-54-8enzymesubstrate18816295 19515014
    Troglitazone-- 97322-87-7enzymesubstrate12433820 12582161
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate11714888
    BuprenorphineBuprenophine (see all 3)52485-79-7enzymesubstrate19515014
    Dabigatran etexilateDabigatran (see all 2)211915-06-9enzymesubstrate20551237
    Etodolac-- 41340-25-4enzymesubstrate19515014
    Ezogabine D-23129 (see all 5)150812-12-7enzymesubstrate10220490

    10/38 Novoseek inferred chemical compound relationships for UGT1A9 gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-hydroxy-n'-acetylbenzidine 84.5 1 10506112 (1)
    sn38 glucuronide 82.5 2 12944498 (1), 16595709 (1)
    glucuronide 81.7 6 9762354 (1), 17359941 (1), 12582161 (1), 10051052 (1) (see all 6)
    uridine diphosphate 81.7 4 17924828 (1), 12201491 (1), 19644937 (1), 18816295 (1)
    mycophenolic acid 80.2 58 17529886 (4), 17924828 (4), 16198654 (3), 17339869 (3) (see all 16)
    sn 38 79.7 8 12944498 (2), 16595709 (2), 20196838 (1)
    n-acetylbenzidine 76.7 1 10506112 (1)
    n-hydroxy phip 76.1 5 11375903 (1), 11408353 (1)
    4-methylumbelliferone 70.3 7 10220484 (1), 16545899 (1), 16278927 (1), 19850672 (1) (see all 5)
    irinotecan 70.1 13 15709193 (2), 12944498 (2), 15864130 (2), 12730278 (1) (see all 10)

    3 PharmGKB related drug/compound annotations for UGT1A9 gene    About this table
    Drug/compound PharmGKB Annotation
    mycophenolate mofetilCA  
    propofolCA  
    valproic acidCA  

    Search CenterWatch for drugs/clinical trials and news about UGT1A9 / UD19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGT1A9 gene: 
    NM_021027.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000354728(uc010zmw.1 uc002vus.3)
    miRNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: UGT1A9 (NM_021027)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT1A9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A9
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    24/271 AceView cDNA sequences (see all 271):

    AK025403 BG165230 CB163341 AU076863 AI478649 CB162031 BE463503 NM_001072 
    AV660038 AY435144 AI795931 AI767337 AI701383 BE464379 AY435143 NM_007120 
    BC053576 NM_019078 AI566081 AW297730 NM_019075 NM_019077 BE464186 AY435142 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT1A9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A9 Expression
    About this image


    See UGT1A9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT1A9

    UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
    Tissue specificity: Liver

        SABiosciences Expression via Pathway-Focused PCR Array including UGT1A9: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A9 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a91 , 5 UDP glucuronosyltransferase 1 family, polypeptide A91, 5 80.72(n)1
    79.69(a)1
      1 (44.50 cM)5
    3944341  NM_201644.21  NP_964006.21 
     880708005 
    chicken
    (Gallus gallus)
    Aves --
    --
    --
    60(a)
    44(a)
    many ↔ many
    many ↔ many
    7(5735050-5897491)
    7(5872756-5873724)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1ab6
    ugt1b46
    UDP glucuronosyltransferase 1 family a, b
    UDP glucuronosyltransferase 1 family, polypeptide ...
    50(a)
    44(a)
    many ↔ many
    many ↔ many
    9(10194767-10228512)
    11(31171792-31204741)


    ENSEMBL Gene Tree for UGT1A9 (if available)
    TreeFam Gene Tree for UGT1A9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT1A9 gene
    UGT1A81 2  UGT1A71 2  UGT1A101 2  UGT2A22  UGT3A12  UGT2B112  UGT2B72  UGT1A32  
    UGT1A12  UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A62  UGT82  UGT2B152  
    UGT2B42  UGT2A32  UGT2B172  UGT2B282  UGT1A42  
    18/30 SIMAP similar genes for UGT1A9 using alignment to 8 protein entries:     UD19_HUMAN (see all proteins) (see all similar genes):
    UGT1A9S    UGT1A8S    UGT1A10    UGT1J    UGT1A8    UGT1A3S
    UGT1H    UGT1A7    UGT1G    UGT1A6    BILIQTL1    UGT1A1
    UGT1A6S    UGT1    UGT1A4S    UGT2A3    UGT1A4    UGT1A3

    UGT1A9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UGT1A9
    PGOHUM00000241147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in UGT1A9 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360354
    A breast cancer sample4--see VAR_0360352 S I mis40--------
    VAR_0585874
    ----see VAR_0585872 M T mis40--------

    HapMap Linkage Disequilibrium report for UGT1A9 (234580499 - 234681951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for UGT1A9 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2661542CNV Deletion23128226
    esv2721664CNV Deletion23290073
    esv2721667CNV Deletion23290073
    esv2721666CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721669CNV Deletion23290073
    esv2721668CNV Deletion23290073
    nsv514125CNV Loss21397061
    nsv433211CNV Loss18776910


    Human Gene Mutation Database (HGMD): UGT1A9
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606434    OMIM disorders: --

    20/23 diseases for UGT1A9 (see all 23):    About MalaCards
    crigler-najjar syndrome    crigler najjar syndrome, type 2    kernicterus    gilbert syndrome
    neonatal jaundice    kawasaki disease    jaundice    cholelithiasis
    neutropenia    sickle cell anemia    cytochrome p450    hepatitis c
    colorectal cancer    hepatocellular carcinoma    hepatitis    liver disease
    pancreatic cancer    colon cancer    lung cancer    anemia

    2 diseases from the University of Copenhagen DISEASES database for UGT1A9:
    Bilirubin metabolic disorder     Kernicterus

    UGT1A9 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for UGT1A9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis autoimmune 21.8 1 11343231 (1)
    cancer 13.8 6 12730278 (2), 17406868 (2), 17700594 (1), 16595709 (1)
    colorectal cancer 7.4 2 15709193 (1), 19364970 (1)
    colon carcinoma 6.96 1 10220484 (1)
    breast cancer 0 1 18430559 (1)
    hepatocellular carcinoma 0 1 11677206 (1)
    hepatitis c 0 1 11343231 (1)

    Genetic Association Database (GAD): UGT1A9
    Human Genome Epidemiology (HuGE) Navigator: UGT1A9 (53 documents)

    Export disorders for UGT1A9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT1A9 gene, integrated from 9 sources (see all 249):
    (articles sorted by number of sources associating them with UGT1A9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9). (PubMed id 18816295)1, 4, 7, 9 Takahashi H....Takeuchi Y. (2008)
    2. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)1, 2, 4, 9 MAcnard V....Guillemette C. (2009)
    3. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family. (PubMed id 1910331)1, 2, 3 Wooster R....Burchell B. (1991)
    4. Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. (PubMed id 15284532)1, 4, 9 Girard H.... Guillemette C. (2004)
    5. N-Glycosylation plays a role in protein folding of hu man UGT1A9. (PubMed id 19951703)1, 2, 9 Nakajima M....Yokoi T. (2010)
    6. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer. (PubMed id 17406868)1, 4, 9 Fujita K....Sasaki Y. (2007)
    7. Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations. (PubMed id 17115150)1, 4, 9 Mehlotra R.K....Zimmerman P.A. (2007)
    8. Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. (PubMed id 11714888)6, 7, 9 Court M.H....Mackenzie P.I. (2001)
    9. Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. (PubMed id 17529886)1, 4, 9 Inoue K....Suzuki T. (2007)
    10. The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients. (PubMed id 16198654)1, 4, 9 Kuypers D.R....Vanrenterghem Y. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54600 HGNC: 12541 AceView: UGT1A1 Ensembl:ENSG00000241119 euGenes: HUgn54600
    ECgene: UGT1A9 Kegg: 54600 H-InvDB: UGT1A9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT1A9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UGT1A9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGT1A9 gene:
    Search GeneIP for patents involving UGT1A9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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