Aliases for UGT1A8 Gene
External Ids for UGT1A8 Gene
Previous GeneCards Identifiers for UGT1A8 Gene
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]
GeneCards Summary for UGT1A8 Gene
UGT1A8 (UDP Glucuronosyltransferase Family 1 Member A8) is a Protein Coding gene. Diseases associated with UGT1A8 include pericholangitis and cholelithiasis. Among its related pathways are Porphyrin and chlorophyll metabolism and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT2B15.
UniProtKB/Swiss-Prot for UGT1A8 Gene
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.