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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT1A7 Gene

protein-coding   GIFtS: 50
GCID: GC02P234581

UDP Glucuronosyltransferase 1 Family, Polypeptide A7

(Previous names: UDP glycosyltransferase 1 family, polypeptide A6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A71 2     UDP Glycosyltransferase 1 Family, Polypeptide A61
UGT-1G2 3     UDPGT2
UGT1-072 3     UDP Glycosyltransferase 1 Family, Polypeptide A72
UGT1.72 3     UDP-Glucuronosyltransferase 1 Family Polypeptide A7s2
UGT1G2 3     UDP-Glucuronosyltransferase 1-72
UDP-Glucuronosyltransferase 1-G2 3     GNT13
UDP-Glucuronosyltransferase 1A72 3     UGT13
UDPGT 1-72 3     UGT1*73
EC 2.4.1.173 8     

External Ids:    HGNC: 125391   Entrez Gene: 545772   Ensembl: ENSG000002441227   OMIM: 6064325   UniProtKB: Q9HAW73   

Export aliases for UGT1A7 gene to outside databases

Previous GC identifers: GC02U990247 GC02P234820 GC02P234883 GC02P234368 GC02P234372 GC02P234198 GC02P234209 GC02P234218 GC02P234255 GC02P226390


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGT1A7 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate
glucuronidase activity with phenols. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A7 Gene: 
UGT1A7 (UDP glucuronosyltransferase 1 family, polypeptide A7) is a protein-coding gene. Diseases associated with UGT1A7 include gilbert syndrome, and pancreatic diseases, and among its related super-pathways are Ascorbate and aldarate metabolism and Phase II conjugation. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds

Gene Wiki entry for UGT1A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT1A7 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   COUP   HNF-4alpha2   PPAR-gamma2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234581:  view genomic region     (about GC identifiers)

Start:
234,590,584 bp from pter      End:
234,681,945 bp from pter
Size:
91,362 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-7 precursor  
Size: 530 amino acids; 59819 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Secondary accessions: O00473
Alternative splicing: 1 isoform:  Q9HAW7-1   

Explore the universe of human proteins at neXtProt for UGT1A7: NX_Q9HAW7

Explore proteomics data for UGT1A7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HAW7

  • 4/25 DME Specific Peptides for UGT1A7 (Q9HAW7) (see all 25)
     PEVSWQL  FWVEFVM  GIFCHYL  WLLRTDF 

    UGT1A7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGT1A7 Protein Expression
    REFSEQ proteins: NP_061950.2  
    ENSEMBL proteins: 
     ENSP00000362525   ENSP00000420181  
    Reactome Protein details: Q9HAW7
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18556656
    GO:0005789endoplasmic reticulum membrane NAS--
    GO:0016021integral to membrane IEA--

    UGT1A7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q9HAW7

    ProtoNet protein and cluster: Q9HAW7

    2 Blocks protein domains:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase


    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT1A7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD17_HUMAN, Q9HAW7
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA--
    GO:0004857enzyme inhibitor activity IDA19996319
    GO:0005080protein kinase C binding IPI18556656
    GO:0008144drug binding IDA--
    GO:0015020glucuronosyltransferase activity IDA18052087
         
    UGT1A7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT1A7:
     Synthetic lethal with imatinib 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UGT1A7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.67
    Starch and sucrose metabolism0.41
    Glucuronidation0.67
    Porphyrin and chlorophyll metabolism0.38
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.33
    Pentose and glucuronate interconversions0.61
    Steroid hormone biosynthesis0.30
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    Retinol metabolism0.39
    5Irinotecan Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UGT1A7
        Glucuronidation
    metapathway biotransformation

    4        Reactome Pathways for UGT1A7
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation

    1 PharmGKB Pathway for UGT1A7
        Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    5/11         Kegg Pathways  (Kegg details for UGT1A7) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT1A7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT1A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT1A7 (ENSP000003625254) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    BLVRAENSP000002655234STRING: ENSP00000265523
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0007588excretion IC--
    GO:0008152metabolic process ----
    GO:0009804coumarin metabolic process IC19996319
    GO:0017144drug metabolic process IDA--

    UGT1A7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT1A7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UGT1A7 (UD17)

    10/84 HMDB Compounds for UGT1A7 (see all 84)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ethyl glucuronide 17685-04-016139098
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----

    10/21 Novoseek inferred chemical compound relationships for UGT1A7 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uridine diphosphate 80 4 16724991 (1), 12669388 (1), 16097053 (1)
    sn 38 79.4 4 12944498 (2), 18349289 (2)
    sn38 glucuronide 76.2 3 18418374 (1), 12181437 (1)
    glucuronide 73.4 2 9762354 (1), 11560872 (1)
    n-hydroxy phip 70.7 3 15310245 (1), 11375903 (1)
    irinotecan 66.5 15 18349289 (3), 15709193 (2), 12944498 (2), 19712005 (2) (see all 9)
    glucuronic acid 59.8 2 16159430 (1)
    flavopiridol 59.3 1 12944498 (1)
    uridine 58.8 3 17529886 (1), 16636344 (1), 17436274 (1)
    mycophenolic acid 53 7 17529886 (5), 18695635 (1)

    1 PharmGKB related drug/compound annotation for UGT1A7 gene    About this table
    Drug/compound PharmGKB Annotation
    valproic acidCA  

    Search CenterWatch for drugs/clinical trials and news about UGT1A7 / UD17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for UGT1A7 gene: 
    NM_019077.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373426(uc010zmx.1 uc002vut.3) ENST00000485022
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    24/271 AceView cDNA sequences (see all 271):

    NM_000463 CB157019 BE464379 AV646429 AY435138 AI767337 CB162031 NM_019076 
    AI479279 BC053576 AY435144 AW297730 NM_019093 BC043491 AI566081 AY435143 
    NM_019075 BE464186 AV660038 BI764371 AI913618 BE464422 BG165230 AK025403 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT1A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A7 Expression
    About this image


    See UGT1A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT1A7

    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Tissue specificity: Liver and gastric tissue

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A7 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a91 UDP glucuronosyltransferase 1 family, polypeptide A9 81.27(n)
    80.5(a)
      394434  NM_201644.2  NP_964006.2 
    chicken
    (Gallus gallus)
    Aves --
    --
    --
    59(a)
    43(a)
    many ↔ many
    many ↔ many
    7(5735050-5897491)
    7(5872756-5873724)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1ab6
    ugt1b46
    UDP glucuronosyltransferase 1 family a, b
    UDP glucuronosyltransferase 1 family, polypeptide ...
    50(a)
    44(a)
    many ↔ many
    many ↔ many
    9(10194767-10228512)
    11(31171792-31204741)


    ENSEMBL Gene Tree for UGT1A7 (if available)
    TreeFam Gene Tree for UGT1A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT1A7 gene
    UGT1A81 2  UGT1A101 2  UGT1A91 2  UGT2A22  UGT3A12  UGT2B112  UGT2B72  UGT1A32  
    UGT1A12  UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A62  UGT82  UGT2B152  
    UGT2B42  UGT2A32  UGT2B172  UGT2B282  UGT1A42  
    18/30 SIMAP similar genes for UGT1A7 using alignment to 16 protein entries:     UD17_HUMAN     Q9H3G1_HUMAN     Q96PP1_HUMAN     Q9H3G0_HUMAN     Q96PP0_HUMAN     Q96PN9_HUMAN     Q5K674_HUMAN     Q5K632_HUMAN     Q5DSZ7_HUMAN     Q4R0Z5_HUMAN     Q9H3G2_HUMAN     Q96DH9_HUMAN     B8K293_HUMAN     Q5K672_HUMAN     H0Y8D7_HUMAN     Q5K673_HUMAN(see all similar genes)(see first protein):
    UGT1G    UGT1A8S    UGT1A9S    UGT1A10    UGT1J    UGT1A8
    UGT1A3S    UGT1H    UGT1A9    UGT1A6    UGT1A6S    UGT2B17
    BILIQTL1    UGT1A1    UGT1    UGT2B28    UGT2B11    UGT1A4S

    UGT1A7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for UGT1A7
    PGOHUM00000241145 PGOHUM00000241146


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Polymorphism: There are four common allelic UGT1A7 variants which exhibit significant differences in catalytic
    activity towards 3-, 7-, and 9-hydroxy-benzo(a)pyrene. UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared
    to UGT1A7*1, whereas UGT1A7*2 and UGT1A7*4 have a 2.6- and 2.8-fold lower relative Vmax than UGT1A7*1,
    respectively, suggesting that these mutations confer slow glucuronidation phenotype


    4 SNPs in UGT1A7 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0155574
    ----see VAR_0155572 R K mis40--------
    VAR_0524624
    ----see VAR_0524622 R Q mis40--------
    VAR_0155584
    ----see VAR_0155582 W R mis40--------
    VAR_0155564
    ----see VAR_0155562 N K mis40--------

    HapMap Linkage Disequilibrium report for UGT1A7 (234590584 - 234681945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for UGT1A7 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2661542CNV Deletion23128226
    esv2721667CNV Deletion23290073
    esv2721666CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721669CNV Deletion23290073
    esv2721668CNV Deletion23290073
    nsv514125CNV Loss21397061
    nsv433211CNV Loss18776910
    nsv498958CNV Loss21111241


    Human Gene Mutation Database (HGMD): UGT1A7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT1A7
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606432    OMIM disorders: --

    20/29 diseases for UGT1A7 (see all 29):    About MalaCards
    gilbert syndrome    pancreatic diseases    pandas    kernicterus
    neonatal jaundice    drug dependence    jaundice    cholelithiasis
    pancreatic cancer    hepatocellular carcinoma    neutropenia    colorectal cancer
    sickle cell anemia    hepatitis b    hepatitis c    cytochrome p450
    pancreatitis    liver cirrhosis    crohn's disease    glomerulonephritis

    2 diseases from the University of Copenhagen DISEASES database for UGT1A7:
    Bilirubin metabolic disorder     Kernicterus

    UGT1A7 for disorders           About GeneDecksing

    10/15 Novoseek inferred disease relationships for UGT1A7 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gilberts syndrome 74.9 5 18349289 (3), 19303655 (1), 17850628 (1)
    pancreatic diseases 49.6 2 12806614 (1), 16199544 (1)
    hyperbilirubinemia 36.2 1 19303655 (1)
    hepatocellular carcinoma 35.3 16 11677206 (3), 18271934 (3), 15073122 (2), 15382168 (1) (see all 8)
    colorectal cancer 33.5 12 16620591 (4), 12010889 (1), 15709193 (1), 19364970 (1) (see all 6)
    chronic pancreatitis 32.3 4 16199544 (2), 12806614 (1), 17325733 (1)
    genetic susceptibility 15.1 3 16159430 (2), 16724991 (1)
    cancer 13 7 11677206 (2), 17406868 (2), 12010889 (1), 16620591 (1) (see all 5)
    hepatitis c 12.8 4 11343231 (1), 18054330 (1), 15073122 (1), 16086712 (1)
    pancreatic cancer 12.8 7 16199544 (4), 17072959 (2), 12806614 (1)

    Genetic Association Database (GAD): UGT1A7
    Human Genome Epidemiology (HuGE) Navigator: UGT1A7 (57 documents)

    Export disorders for UGT1A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT1A7 gene, integrated from 9 sources (see all 153):
    (articles sorted by number of sources associating them with UGT1A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)1, 2, 4, 9 MAcnard V....Guillemette C. (2009)
    2. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)1, 2, 3, 9 Gong Q.H....Popescu N.C. (2001)
    3. Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer. (PubMed id 16030093)1, 4, 9 Butler L.M....Guillemette C. (2005)
    4. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. (PubMed id 16086712)1, 4, 9 Tseng C.S....Huang C.S. (2005)
    5. Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. (PubMed id 15682470)1, 4, 9 Huang M.J....Huang C.S. (2005)
    6. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. (PubMed id 11037804)1, 2, 9 Guillemette C.... Housman D.E. (2000)
    7. UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis. (PubMed id 18054330)1, 4, 9 Tang K.S....Huang C.S. (2008)
    8. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer. (PubMed id 17406868)1, 4, 9 Fujita K....Sasaki Y. (2007)
    9. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. (PubMed id 16199544)1, 4, 9 Verlaan M....Witt H. (2005)
    10. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. (PubMed id 12010889)1, 4, 9 Strassburg C.P....Manns M.P. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54577 HGNC: 12539 AceView: UGT1A1 Ensembl:ENSG00000244122 euGenes: HUgn54577
    ECgene: UGT1A7 Kegg: 54577 H-InvDB: UGT1A7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT1A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGT1A7 gene:
    Search GeneIP for patents involving UGT1A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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