UGT1A7 Gene

Aliases
for UGT1A7 gene

Previous GC identifers: GC02U990247 GC02P234820 GC02P234883 GC02P234368 GC02P234372 GC02P234198 GC02P234209 GC02P234218 GC02P234255 GC02P226390

Summaries
for UGT1A7 gene

Genomic Views
for UGT1A7 gene

Browse SwitchGear Promoter luciferase reporter plasmids

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A7

UGT1A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234581:  view genomic region     (about GC identifiers)

Proteins
for UGT1A7 gene

Explore the universe of human proteins at neXtProt for UGT1A7: NX_Q9HAW7

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Uscn Proteins for UGT1A7

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

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Protein Domains /
Families
for UGT1A7 gene

ProtoNet protein and cluster: Q9HAW7

Function
for UGT1A7 gene

Enzyme Number (IUBMB): EC 2.4.1.17^{1 2}

miRNA Products:		OriGene 3'-UTR Clone: UGT1A7 Browse MicroRNA Expression Plasmids
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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate UGT1A7:
		hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
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Gene Editing Products:

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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A7 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A7 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A7

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

Pathways & Interactions
for UGT1A7 gene

	Super-pathway	contained gene-specific pathways
1	Glucuronidation	Glucuronidation 1.00 Porphyrin and chlorophyll metabolism 0.38 Glucuronidation 0.67 Other types of O-glycan biosynthesis 0.36 Starch and sucrose metabolism 0.42 Drug metabolism - other enzymes 0.32
2	Drug metabolism - cytochrome P450	Drug metabolism - cytochrome P450 1.00 Retinol metabolism 0.40 Metabolism of xenobiotics by cytochrome P450 0.73
3	Biological oxidations	Biological oxidations 1.00 metapathway biotransformation 0.41 Phase II conjugation 0.52
4	Metabolism	Metabolism 1.00 Metabolic pathways 0.38
5	Pentose and glucuronate interconversions	Pentose and glucuronate interconversions 1.00 Ascorbate and aldarate metabolism 0.62

2 BioSystems Pathways for UGT1A7

	Glucuronidation
	metapathway biotransformation

4        Reactome Pathways for UGT1A7

	Metabolism
	Biological oxidations
	Phase II conjugation
	Glucuronidation

1 PharmGKB Pathway for UGT1A7

Mycophenolic acid Pathway, Pharmacokinetics

5/11         Kegg Pathways  (Kegg details for UGT1A7)

	Pentose and glucuronate interconversions
	Ascorbate and aldarate metabolism
	Steroid hormone biosynthesis
	Starch and sucrose metabolism
	Other types of O-glycan biosynthesis

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for UGT1A7 gene

Transcripts
for UGT1A7 gene

Expression
for UGT1A7 gene

UGT1A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT1A7 Browse OriGene validated miRNA SYBR primer pairs
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A7

Orthologs
for UGT1A7 gene

Paralogs
for UGT1A7 gene

Paralogs for UGT1A7 gene

UGT1A8^1 2  UGT1A10^1 2  UGT1A9^1 2  UGT2A2²  UGT3A1²  UGT2B7²  UGT2B11²  UGT1A3²  

UGT1A1²  UGT1A5²  UGT3A2²  UGT2B10²  UGT1A6²  UGT8²  UGT2B15²  UGT2B4²  

UGT2B17²  UGT2A3²  UGT2B28²  UGT1A4²  

18/30 SIMAP similar genes for UGT1A7 using alignment to 16 protein entries:     UD17_HUMAN (see all proteins) (see all similar genes):

UGT1G    UGT1A8S    UGT1A9S    UGT1A10    UGT1J    UGT1A8

UGT1A3S    UGT1H    UGT1A9    UGT1A6    UGT1A6S    UGT2B17

BILIQTL1    UGT1A1    UGT1    UGT2B28    UGT2B11    UGT1A4S

UGT1A7 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for UGT1A7
PGOHUM00000241145 PGOHUM00000241146

Genomic Variants
for UGT1A7 gene

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for UGT1A7
     10 CNVs: 90342 90341 61892 35795 50416 39282 37520 39281 63332 90340
Human Gene Mutation Database (HGMD): UGT1A7

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT1A7

DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A7

Disorders / Diseases
for UGT1A7 gene

20/29 diseases for UGT1A7

10/15 Novoseek disease relationships for UGT1A7 gene (see all 15)    About this table

Publications
for UGT1A7 gene

PubMed articles for UGT1A7 gene, integrated from 9 sources (see all 150) (see top 10): (articles sorted by number of sources associating them with UGT1A7)

Utopia: connect your pdf to the dynamic world of online information

1. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)^{1, 2, 3, 9} Gong Q.H....Popescu N.C. (2001)
2. Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer. (PubMed id 16030093)^{1, 4, 9} Butler L.M....Guillemette C. (2005)
3. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. (PubMed id 16086712)^{1, 4, 9} Tseng C.S....Huang C.S. (2005)
4. Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. (PubMed id 15682470)^{1, 4, 9} Huang M.J....Huang C.S. (2005)
5. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. (PubMed id 11037804)^{1, 2, 9} Guillemette C.... Housman D.E. (2000)
6. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. (PubMed id 16199544)^{1, 4, 9} Verlaan M....Witt H. (2005)
7. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. (PubMed id 12010889)^{1, 4, 9} Strassburg C.P....Manns M.P. (2002)
8. [Correlation of polymorphisms of UDP-glucuronosyltransferase 1A7 gene to genetic susceptibility of lung cancer] (PubMed id 16159430)^{1, 4, 9} Feng F.Y....Lin D.X. (2005)
9. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection. (PubMed id 15073122)^{1, 4, 9} Wang Y....Omata M. (2004)
10. UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. (PubMed id 12806614)^{1, 4, 9} Ockenga J....Strassburg C.P. (2003)
11. Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. (PubMed id 9271343)^{1, 2, 9} Strassburg C.P.... Tukey R.H. (1997)
12. Polymorphism of UDP-glucuronosyltransferase 1A7 gene: a possible new risk factor for lung cancer. (PubMed id 16143514)^{1, 4, 9} Araki J....Adachi Y. (2005)
13. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. (PubMed id 15709193)^{1, 4, 9} Carlini L.E....Blanchard R.L. (2005)
14. Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. (PubMed id 11677206)^{1, 4, 9} Vogel A....Strassburg C.P. (2001)
15. Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. (PubMed id 15319294)^{1, 4, 9} van der Logt E.M....Peters W.H. (2004)
16. Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene. (PubMed id 16097053)^{1, 4, 9} Machida H....Wen C.Y. (2005)
17. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)^{1, 2, 9} MAcnard V....Guillemette C. (2009)
18. Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes. (PubMed id 15929176)^{1, 4, 9} Tang K.S....Huang C.S. (2005)
19. Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer. (PubMed id 12122597)^{1, 4} Vogel A....Strassburg C.P. (2002)
20. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PubMed id 9295054)^{1, 3} Mackenzie P.I....Nebert D.W. (1997)
21. UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls. (PubMed id 17325733)^{1, 9} te Morsche R.H....Witt H. (2008)
22. UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis. (PubMed id 18054330)^{1, 9} Tang K.S....Huang C.S. (2008)
23. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer. (PubMed id 17406868)^{1, 9} Fujita K....Sasaki Y. (2007)
24. Linkage disequilibrium of UGT1A1 *6 and UGT1A1 *28 in relation to UGT1A6 and UGT1A7 polymorphisms. (PubMed id 16969497)^{1, 9} Urawa N....Adachi Y. (2006)
25. Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer. (PubMed id 19360737)^{1, 9} Lacko M....Manni J.J. (2009)
26. [Association between genetic polymorphism of UGT1A7 a nd susceptibility of bladder cancer] (PubMed id 20193274)^{1, 9} Liu J....Song D.K. (2009)
27. UGT1A7 haplotype is associated with an increased risk of hepatocellular carcinoma in hepatitis B carriers. (PubMed id 18271934)^{1, 9} Kong S.Y....Kim J.W. (2008)
28. Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. (PubMed id 17529886)^{1, 9} Inoue K....Suzuki T. (2007)
29. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PubMed id 17072959)^{1, 9} Piepoli A....Perri F. (2006)
30. [Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer] (PubMed id 16620591)^{1, 9} Fan C.H....Chen K. (2006)
31. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. (PubMed id 12944498)^{1, 9} Villeneuve L.... Guillemette C. (2003)
32. Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. (PubMed id 18349289)^{1, 9} Lankisch T.O....Strassburg C.P. (2008)
33. Combined UGT1A1 and UGT1A7 variant alleles are associated with increased risk of Gilbert's syndrome in Taiwanese adults. (PubMed id 17850628)^{1, 9} Teng H.C....Huang C.S. (2007)
34. UGT1A1, UGT1A6 and UGT1A7 genetic analysis: repercuss ion for irinotecan pharmacogenetics in the SALo Miguel Island Population (Azores , Portugal). (PubMed id 19712005)^{1, 9} Pacheco P.R....Mota-Vieira L. (2009)
35. Uridine Diphosphoglucuronosyltransferase 1A7 Gene Polymorphism and Susceptibility to Chromosomal Damage Among Polycyclic Aromatic Hydrocarbons Exposed Workers. (PubMed id 19430315)^{1, 9} Wang Y....Zheng Y. (2009)
36. Genetic polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population. (PubMed id 17479406)^{1, 9} Gu S.Y....Xia Z.L. (2007)
37. UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers? (PubMed id 18021430)^{1, 9} Stucker I....Pelletier G. (2007)
38. Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population. (PubMed id 16724991)^{1, 9} Chen K....Yao K. (2006)
39. Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein int eractions. (PubMed id 19996319)^{1, 9} Bellemare J....Guillemette C. (2010)
40. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. (PubMed id 19364970)^{1, 9} Cecchin E....Toffoli G. (2009)
41. Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers. (PubMed id 18597651)^{1, 9} Levesque E....Guillemette C. (2008)
42. Influence of Drug Transporters and UGT Polymorphisms on Pharmacokinetics of Phenolic glucuronide Metabolite of Mycophenolic Acid in Japanese Renal Transplant Recipients. (PubMed id 18695635)^{1, 9} Miura M....Suzuki T. (2008)
43. DNA-repair and carcinogen-metabolising enzymes genetic polymorphisms as an independent risk factor for hepatocellular carcinoma in Caucasian liver-transplanted patients. (PubMed id 17870518)^{1, 9} Borentain P....Gerolami R. (2007)
44. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. (PubMed id 16636344)^{1, 9} Han J.Y....Lee J.S. (2006)
45. Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. (PubMed id 14557274)^{1, 9} Basu N.K....Owens I.S. (2004)
46. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. (PubMed id 20297805)^{1, 9} Tang L....Hu M. (2010)
47. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. (PubMed id 19303655)^{1, 9} Lankisch T.O....Strassburg C.P. (2009)
48. The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. (PubMed id 18556656)^{1, 9} Basu N.K....Owens I.S. (2008)
49. Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population. (PubMed id 18223459)^{1, 9} Yea S.S....Shin J.G. (2008)
50. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. (PubMed id 18052087)^{1, 9} Joseph T.B....Hu M. (2007)
51. UGT1A1 is a major locus influencing bilirubin levels i n African Americans. (PubMed id 22085899)¹ Chen G....Rotimi C.N. (2012)
52. A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Yo ung Finns Study. (PubMed id 22511988)¹ Jylhava J....Hurme M. (2012)
53. Association between polymorphisms in UDP-glucuronosylt ransferase 1A6 and 1A7 and colorectal cancer risk. (PubMed id 22901212)¹ Osawa K....Kido Y. (2012)
54. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. (PubMed id 22558097)¹ Milton J.N....Klings E.S. (2012)
55. The association between UGT1A7 polymorphism and cancer risk: a meta-analysis. (PubMed id 22402308)¹ Han S.X....Wu D.Q. (2012)
56. Genotyping of the UDP-glucuronosyltransferase (UGT) 1 A7 gene revisited. (PubMed id 21440586)¹ Vogel A....Strassburg C.P. (2011)
57. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circ ulating bilirubin levels. (PubMed id 21646302)¹ Bielinski S.J....Chute C.G. (2011)
58. Human metabolic individuality in biomedical and pharma ceutical research. (PubMed id 21886157)¹ Suhre K....Gieger C. (2011)
59. Genetic polymorphisms of UGT1A7 and cancer risk: evid ence from 21 case-control studies. (PubMed id 22085268)¹ Lu P.H....Gu R.M. (2011)
60. Polymorphisms in CYP2A13 and UGT1A7 genes and head an d neck cancer susceptibility in North Indians. (PubMed id 20534012)¹ Sharma R....Khullar M. (2010)
61. Risk of diarrhoea in a long-term cohort of renal tran splant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele. (PubMed id 20565459)¹ Woillard J.B....Le Meur Y. (2010)
62. UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and f luorouracil combination therapy. (PubMed id 20628391)¹ Martinez-Balibrea E....Moreno V. (2010)
63. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
64. Effects of uridine diphosphate glucuronosyltransferas e 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. (PubMed id 20567810)¹ Joy M.S....Smith P.C. (2010)
65. Phase II study of a triplet regimen of S-1 combined w ith irinotecan and oxaliplatin in patients with metastatic gastric cancer: clin ical and pharmacogenetic results. (PubMed id 20860988)¹ Park S.R....Kim N.K. (2010)
66. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)¹ Jugessur A....Murray J.C. (2010)
67. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)¹ Ross C.J....Hayden M.R. (2009)
68. Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)¹ Johnson A.D....Witteman J.C. (2009)
69. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
70. Fulfilling the promise of personalized medicine? Syst ematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)¹ Holmes M.V....Casas J.P. (2009)
71. Common variants in the SLCO1B3 locus are associated w ith bilirubin levels and unconjugated hyperbilirubinemia. (PubMed id 19419973)¹ Sanna S....Uda M. (2009)
72. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. (PubMed id 19349540)¹ Innocenti F....Ratain M.J. (2009)
73. Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. (PubMed id 18990750)¹ Cotterchio M....Harper P.A. (2008)
74. Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. (PubMed id 17558305)¹ Minami H....Saijo N. (2007)
75. Assessment of UDP-glucuronosyltransferase catalyzed formation of ethyl glucuronide in human liver microsomes and recombinant UGTs. (PubMed id 16139098)⁶ Foti R.S. and Fisher M.B. (2005)
76. Multiple variable first exons: a mechanism for cell- and tissue- specific gene regulation. (PubMed id 14672974)¹ Zhang T.... Wu Q. (2004)
77. Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. (PubMed id 12732365)¹ Kohle C....Bock K.W. (2003)
78. Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. (PubMed id 12815363)⁴ Guillemette C. (2003)
79. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
80. Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk. (PubMed id 11562393)¹ Zheng Z....Lazarus P. (2001)
81. UDP-glucuronosyltransferases. (PubMed id 11465080)¹ King C.D....Tephly T.R. (2000)
82. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. (PubMed id 10836148)¹ Tukey R.H. and Strassburg C.P. (2000)
83. Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. (PubMed id 8467709)¹ van Es H.H....Schurr E. (1993)
84. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. (PubMed id 9463278)⁹ Bruck M....Tukey R.H. (1997)
85. Differential protection by rat UDP-glucuronosyltransferase 1A7 against Benzo[a]pyrene-3,6-quinone- versus Benzo[a]pyrene-induced cytotoxic effects in human lymphoblastoid cells. (PubMed id 10631125)⁹ Grove A.D....Ritter J.K. (2000)
86. Involvement of hepatocyte nuclear factor 1 in the regulation of the UDP-glucuronosyltransferase 1A7 (UGT1A7) gene in rat hepatocytes. (PubMed id 10908299)⁹ Metz R.P....Ritter J.K. (2000)
87. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. (PubMed id 9264550)⁹ Bruck M....Tukey R.H. (1997)
88. Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. (PubMed id 15716465)⁹ Lankisch T.O....Strassburg C.P. (2005)
89. Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. (PubMed id 10024527)⁹ Strassburg C.P....Tukey R.H. (1999)
90. Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha. (PubMed id 15470081)⁹ Barbier O....Staels B. (2005)
91. Glucuronidation of 3'-azido-3'-deoxythymidine catalyzed by human liver UDP-glucuronosyltransferase. Significance of nucleoside hydrophobicity and inhibition by xenobiotics. (PubMed id 1907149)⁹ Resetar A....Spector T. (1991)
92. Novel single nucleotide polymorphism of UGT1A7 gene in Japanese. (PubMed id 16547397)⁹ Fujita K....Sasaki Y. (2006)
93. Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity. (PubMed id 15845768)⁹ Basu N.K....Owens I.S. (2005)
94. Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. (PubMed id 15364550)⁹ Gregory P.A....Mackenzie P.I. (2004)
95. Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes. (PubMed id 11929814)⁹ Fang J.L....Lazarus P. (2002)
96. Glucuronidation of 1-hydroxypyrene by human liver microsomes and human UDP-glucuronosyltransferases UGT1A6, UGT1A7, and UGT1A9: development of a high-sensitivity glucuronidation assay for human tissue. (PubMed id 11454727)⁹ Luukkanen L....Elovaara E. (2001)
97. Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus. (PubMed id 10381366)⁹ Ciotti M....Owens I.S. (1999)
98. Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. (PubMed id 9765507)⁹ Strassburg C.P....Tukey R.H. (1998)
99. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. (PubMed id 9535849)⁹ Strassburg C.P.... Tukey R.H. (1998)
100. Phase II metabolism of hesperetin by individual UDP-g lucuronosyltransferases and sulfotransferases and rat and human tissue samples. (PubMed id 20056724)⁹ Brand W....Rietjens I.M. (2010)
101. Key amino acid residues responsible for the differences in substrate specificity of human UDP-glucuronosyltransferase (UGT)1A9 and UGT1A8. (PubMed id 18832479)⁹ Fujiwara R....Yokoi T. (2009)
102. Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters. (PubMed id 19082692)⁹ Chu X.Y....Evers R. (2009)
103. Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. (PubMed id 18004212)⁹ Girard H....Guillemette C. (2007)
104. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. (PubMed id 17179145)⁹ Operana T.N. and Tukey R.H. (2007)
105. Hepatocyte nuclear factor1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4alpha. (PubMed id 17264800)⁹ Gardner-Stephen D.A. and Mackenzie P.I. (2007)
106. Glucuronidation of thyroxine in human liver, jejunum, and kidney microsomes. (PubMed id 17591679)⁹ Yamanaka H....Yokoi T. (2007)
107. Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation. (PubMed id 16790555)⁹ Loureiro A.I....Soares-Da-Silva P. (2006)
108. Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. (PubMed id 15566942)⁹ Lampen A....Seidel A. (2004)
109. UGT1A7 polymorphisms, polycyclic aromatic hydrocarbons and the development of hepatocellular cancer. (PubMed id 15382168)⁹ Kuchenbauer F....Beuers U. (2004)
110. Multiple pharmacophores for the investigation of human UDP-glucuronosyltransferase isoform substrate selectivity. (PubMed id 14742671)⁹ Sorich M.J....Smith P.A. (2004)
111. Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. (PubMed id 15117964)⁹ Basu N.K....Owens I.S. (2004)
112. Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. (PubMed id 12730278)⁹ Jinno H....Sawada J. (2003)
113. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). (PubMed id 12181437)⁹ Gagne J.F....Guillemette C. (2002)
114. Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms. (PubMed id 12019188)⁹ Nakajima M....Yokoi T. (2002)
115. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. (PubMed id 11375903)⁹ Yueh M.F....Tukey R.H. (2001)
116. Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles: studies of human UDP-glucuronosyltransferases involved and substrate specificities. (PubMed id 11560872)⁹ Vashishtha S.C....McCann D.J. (2001)
117. Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. (PubMed id 11343231)⁹ Bachrich T....Penner E. (2001)
118. AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms. (PubMed id 9762354)⁹ Bock K.W....Bock-Hennig B. (1998)
119. Expression and inducibility of UDP-glucuronosyltransf erases 1-naphthol in human cultured hepatocytes and hepatocarcinoma cell lines. (PubMed id 9180348)⁹ Abid A....Magdalou J. (1997)
120. Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases. (PubMed id 19850672)⁹ Liu Y....Ratain M.J. (2010)
121. Characterization of human hepatic and extrahepatic UD P-glucuronosyltransferase enzymes involved in the metabolism of classic cannabi noids. (PubMed id 19339377)⁹ Mazur A....Moran J.H. (2009)
122. Comparative gene expression of intestinal metabolizin g enzymes. (PubMed id 19746353)⁹ Shin H.C....Amidon G.L. (2009)
123. In silico and in vitro approaches to elucidate the th ermal stability of human UDP-glucuronosyltransferase (UGT) 1A9. (PubMed id 19571435)⁹ Fujiwara R....Yokoi T. (2009)
124. Pharmacogenetic pathway analysis of irinotecan. (PubMed id 18418374)⁹ Rosner G.L....Ratain M.J. (2008)
125. The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases. (PubMed id 18719240)⁹ Itaaho K....Finel M. (2008)
126. Glucuronidation of tobacco-specific nitrosamines by UGT2B10. (PubMed id 18238858)⁹ Chen G....Lazarus P. (2008)
127. Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor. (PubMed id 17761779)⁹ Omura K....Nagata O. (2007)
128. In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. (PubMed id 17701830)⁹ Lee H.S....Kim S.Y. (2007)
129. Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk. (PubMed id 17436274)⁹ Ralph D.A....Jupe E.R. (2007)
130. Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. (PubMed id 17664247)⁹ Sun D....Lazarus P. (2007)
131. Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype. (PubMed id 17058217)⁹ Lankisch T.O....Strassburg C.P. (2006)
132. Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4. (PubMed id 16480962)⁹ Ogura K....Hiratsuka A. (2006)
133. Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. (PubMed id 16609363)⁹ Boyd M.A....Miners J.O. (2006)
134. Determination of drug glucuronidation and UDP-glucuronosyltransferase selectivity using a 96-well radiometric assay. (PubMed id 15788539)⁹ Di Marco A....Laufer R. (2005)
135. Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)- 5-(2-furyl)-4-oxazoleacetic acid (TA-1801A). (PubMed id 15988124)⁹ Kaji H. and Kume T. (2005)
136. UDP-glucuronosyltransferases and clinical drug-drug interactions. (PubMed id 15781124)⁹ Kiang T.K....Chang T.K. (2005)
137. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. (PubMed id 16399343)⁹ Bock K.W. and Kohle C. (2005)
138. Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform. (PubMed id 15608137)⁹ Kaji H. and Kume T. (2005)
139. Amino acid residue ILE211 is essential for the enzymatic activity of human UDP-glucuronosyltransferase 1A10 (UGT1A10). (PubMed id 15039300)⁹ Martineau I....Belanger A. (2004)
140. Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (PubMed id 15247627)⁹ Verlaan M....Drenth J.P. (2004)
141. Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract. (PubMed id 15535975)⁹ Sabolovic N....Magdalou J. (2004)
142. Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro. (PubMed id 15310245)⁹ Malfatti M.A. and Felton J.S. (2004)
143. Analysis of double-stranded DNA by microchip capillar y electrophoresis using polymer solutions containing gold nanoparticles. (PubMed id 14558611)⁹ Lin Y.W....Chang H.T. (2003)
144. [Pharmacogenomic approaches for prevention of drug toxicity in cancer chemotherapy] (PubMed id 12669388)⁹ Hasegawa Y. (2003)
145. Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. (PubMed id 12657745)⁹ Iyer L.V....Green C.E. (2003)
146. Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. (PubMed id 12433820)⁹ Watanabe Y....Yokoi T. (2002)
147. Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes. (PubMed id 12433823)⁹ Nakajima M....Yokoi T. (2002)
148. N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. (PubMed id 12167564)⁹ Ghosheh O. and Hawes E.M. (2002)

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