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UGT1A7 Gene

protein-coding   GIFtS: 50
GCID: GC02P234581

UDP Glucuronosyltransferase 1 Family, Polypeptide A7

(Previous names: UDP glycosyltransferase 1 family, polypeptide A6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A71 2     UDP Glycosyltransferase 1 Family, Polypeptide A61
UGT-1G2 3     UDPGT2
UGT1-072 3     UDP Glycosyltransferase 1 Family, Polypeptide A72
UGT1.72 3     UDP-Glucuronosyltransferase 1 Family Polypeptide A7s2
UGT1G2 3     UDP-Glucuronosyltransferase 1-72
UDP-Glucuronosyltransferase 1-G2 3     GNT13
UDP-Glucuronosyltransferase 1A72 3     UGT13
UDPGT 1-72 3     UGT1*73
EC 2.4.1.173 8     

External Ids:    HGNC: 125391   Entrez Gene: 545772   Ensembl: ENSG000002441227   OMIM: 6064325   UniProtKB: Q9HAW73   

Export aliases for UGT1A7 gene to outside databases

Previous GC identifers: GC02U990247 GC02P234820 GC02P234883 GC02P234368 GC02P234372 GC02P234198 GC02P234209 GC02P234218 GC02P234255 GC02P226390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UGT1A7 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate
glucuronidase activity with phenols. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A7 Gene:
UGT1A7 (UDP glucuronosyltransferase 1 family, polypeptide A7) is a protein-coding gene. Diseases associated with UGT1A7 include gilbert syndrome, and bilirubin metabolic disorder. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds

Gene Wiki entry for UGT1A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the UGT1A7 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   COUP   HNF-4alpha2   PPAR-gamma2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UGT1A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT1A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234581:  view genomic region     (about GC identifiers)

Start:
234,590,584 bp from pter      End:
234,681,945 bp from pter
Size:
91,362 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-7 precursor  
Size: 530 amino acids; 59819 Da
Secondary accessions: O00473
Alternative splicing: 1 isoform:  Q9HAW7-1   

Explore the universe of human proteins at neXtProt for UGT1A7: NX_Q9HAW7

Explore proteomics data for UGT1A7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn292, Asn344
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGT1A7 (Q9HAW7) (see all 25)
     PEVSWQL  FWVEFVM  GIFCHYL  WLLRTDF 


    See UGT1A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061950.2  
    ENSEMBL proteins: 
     ENSP00000362525   ENSP00000420181  
    Reactome Protein details: Q9HAW7

    UGT1A7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q9HAW7

    ProtoNet protein and cluster: Q9HAW7

    2 Blocks protein domains:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase


    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT1A7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD17_HUMAN, Q9HAW7
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA--
    GO:0004857enzyme inhibitor activity IDA19996319
    GO:0005080protein kinase C binding IPI18556656
    GO:0008144drug binding IDA--
    GO:0015020glucuronosyltransferase activity IDA18052087
         
    UGT1A7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT1A7:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT1A7
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    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UD17_HUMAN, Q9HAW7: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    golgi apparatus2
    nucleus2
    peroxisome2
    plasma membrane2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18556656
    GO:0005789endoplasmic reticulum membrane NAS--
    GO:0016021integral component of membrane IEA--

    UGT1A7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGT1A7 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    Glucuronidation0.00
    3Metabolism of porphyrins
    Metabolism of porphyrins0.56
    Heme degradation0.00
    Porphyrin and chlorophyll metabolism0.56
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    5Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UGT1A7
        Glucuronidation
    metapathway biotransformation

    1 Reactome Pathway for UGT1A7
        Glucuronidation

    1 PharmGKB Pathway for UGT1A7
        Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for UGT1A7) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT1A7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UGT1A7
    Interactions:

        GeneGlobe Interaction Network for UGT1A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT1A7 (ENSP000003625254) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH6ENSP000003783594STRING: ENSP00000378359
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0007588excretion IC--
    GO:0008152metabolic process ----
    GO:0009804coumarin metabolic process IC19996319
    GO:0017144drug metabolic process IDA--

    UGT1A7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT1A7 (UD17)

    Selected HMDB Compounds for UGT1A7 (see all 84)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ethyl glucuronide 17685-04-016139098
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----

    Selected Novoseek inferred chemical compound relationships for UGT1A7 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uridine diphosphate 80 4 16724991 (1), 12669388 (1), 16097053 (1)
    sn 38 79.4 4 12944498 (2), 18349289 (2)
    sn38 glucuronide 76.2 3 18418374 (1), 12181437 (1)
    glucuronide 73.4 2 9762354 (1), 11560872 (1)
    n-hydroxy phip 70.7 3 15310245 (1), 11375903 (1)
    irinotecan 66.5 15 18349289 (3), 15709193 (2), 12944498 (2), 19712005 (2) (see all 9)
    glucuronic acid 59.8 2 16159430 (1)
    flavopiridol 59.3 1 12944498 (1)
    uridine 58.8 3 17529886 (1), 16636344 (1), 17436274 (1)
    mycophenolic acid 53 7 17529886 (5), 18695635 (1)

    1 PharmGKB related drug/compound annotation for UGT1A7 gene    About this table
    Drug/compound PharmGKB Annotation
    valproic acidCA  



    UGT1A7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UGT1A7 gene: 
    NM_019077.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373426(uc010zmx.1 uc002vut.3) ENST00000485022
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      QuantiFast Probe-based Assays in human, mouse, rat UGT1A7

    Selected AceView cDNA sequences (see all 271):

    AY435141 CB162031 BE464379 BE464422 BC053576 BI764371 AI479279 BG165230 
    AI767337 NM_019077 NM_205862 AY435136 CB163341 BE464186 NM_019093 AY435143 
    BE463503 AU076863 NM_019076 AV646429 AW297730 BC043491 AV650286 NM_001072 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UGT1A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A7 Expression
    About this image

    UGT1A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT1A7 Protein Expression

    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Tissue specificity: Liver and gastric tissue

        Custom PCR Arrays for UGT1A7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A7 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a91 UDP glucuronosyltransferase 1 family, polypeptide A9 81.44(n)
    80.98(a)
      394434  NM_201644.2  NP_964006.2 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    59(a)
    42(a)
    many ↔ many
    many ↔ many
    7(5735050-5897491)
    7(5872756-5873724)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    many ↔ many
    6(58626676-58649813)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1a76
    ugt1b46
    (see all 6)
    UDP glucuronosyltransferase 1 family, polypeptide ...
    UDP glucuronosyltransferase 1 family, polypeptide ...
    (see all 6)
    49(a)
    46(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    9(10194767-10228491) ENSDARG00000006220
    11(31182060-31204509) ENSDARG00000097024


    ENSEMBL Gene Tree for UGT1A7 (if available)
    TreeFam Gene Tree for UGT1A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGT1A7 gene
    UGT1A81 2  UGT1A101 2  UGT1A91 2  UGT2A22  UGT3A12  UGT2B112  UGT2B72  UGT1A32  
    UGT1A12  UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A62  UGT82  UGT2B152  
    UGT2B42  UGT2A32  UGT2B172  UGT2B282  UGT1A42  
    Selected SIMAP similar genes for UGT1A7 using alignment to 16 protein entries:     UD17_HUMAN (see all proteins) (see all similar genes):
    UGT1G    UGT1A8S    UGT1A9S    UGT1A10    UGT1J    UGT1A8
    UGT1A3S    UGT1H    UGT1A9    UGT1A6    UGT1A6S    UGT2B17
    BILIQTL1    UGT1A1    UGT1    UGT2B28    UGT2B11    UGT1A4S

    UGT1A7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for UGT1A7
    PGOHUM00000241145 PGOHUM00000241146


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    UD17_HUMAN, Q9HAW7: There are four common allelic UGT1A7 variants which exhibit significant differences in catalytic
    activity towards 3-, 7-, and 9-hydroxy-benzo(a)pyrene. UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared
    to UGT1A7*1, whereas UGT1A7*2 and UGT1A7*4 have a 2.6- and 2.8-fold lower relative Vmax than UGT1A7*1,
    respectively, suggesting that these mutations confer slow glucuronidation phenotype


    4 SNPs for UGT1A7    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0155574
    ----see VAR_0155572 R K mis40--------
    rs178683241,2,4
    ----see VAR_0524622 mis40--------
    rs116920211,2,4
    ----see VAR_0155582 mis40--------
    rs178683231,2,4
    ----see VAR_0155562 mis40--------

    HapMap Linkage Disequilibrium report for UGT1A7 (234590584 - 234681945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGT1A7 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2661542CNV Deletion23128226
    esv2721667CNV Deletion23290073
    esv2721666CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721669CNV Deletion23290073
    esv2721668CNV Deletion23290073
    nsv514125CNV Loss21397061
    nsv433211CNV Loss18776910
    nsv498958CNV Loss21111241

    Human Gene Mutation Database (HGMD): UGT1A7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT1A7
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606432    OMIM disorders: --

    Selected diseases for UGT1A7 (see all 24):    About MalaCards
    gilbert syndrome    bilirubin metabolic disorder    sickle cell anemia    pandas
    neonatal jaundice    kernicterus    cholelithiasis    drug dependence
    hepatocellular carcinoma    pancreatic cancer    colorectal cancer    neutropenia
    hepatitis c    hepatitis b    pancreatitis    liver cirrhosis
    glomerulonephritis    crohn's disease    hepatitis    hepatitis c virus

    2 diseases from the University of Copenhagen DISEASES database for UGT1A7:
    Bilirubin metabolic disorder     Kernicterus

    UGT1A7 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for UGT1A7 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gilberts syndrome 74.9 5 18349289 (3), 19303655 (1), 17850628 (1)
    pancreatic diseases 49.6 2 12806614 (1), 16199544 (1)
    hyperbilirubinemia 36.2 1 19303655 (1)
    hepatocellular carcinoma 35.3 16 11677206 (3), 18271934 (3), 15073122 (2), 15382168 (1) (see all 8)
    colorectal cancer 33.5 12 16620591 (4), 12010889 (1), 15709193 (1), 19364970 (1) (see all 6)
    chronic pancreatitis 32.3 4 16199544 (2), 12806614 (1), 17325733 (1)
    genetic susceptibility 15.1 3 16159430 (2), 16724991 (1)
    cancer 13 7 11677206 (2), 17406868 (2), 12010889 (1), 16620591 (1) (see all 5)
    hepatitis c 12.8 4 11343231 (1), 18054330 (1), 15073122 (1), 16086712 (1)
    pancreatic cancer 12.8 7 16199544 (4), 17072959 (2), 12806614 (1)

    Genetic Association Database (GAD): UGT1A7
    Human Genome Epidemiology (HuGE) Navigator: UGT1A7 (57 documents)

    Export disorders for UGT1A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for UGT1A7 gene, integrated from 10 sources (see all 154) (see top 10):
    (articles sorted by number of sources associating them with UGT1A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)1, 2, 4, 9 Menard V.... Guillemette C. (Hum. Mutat. 2009)
    2. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)1, 2, 3, 9 Gong Q.H.... Popescu N.C. (Pharmacogenetics 2001)
    3. Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer. (PubMed id 16030093)1, 4, 9 Butler L.M....Guillemette C. (amp 2005)
    4. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. (PubMed id 16086712)1, 4, 9 Tseng C.S....Huang C.S. (Am. J. Gastroenterol. 2005)
    5. Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. (PubMed id 15682470)1, 4, 9 Huang M.J....Huang C.S. (World J. Gastroenterol. 2005)
    6. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. (PubMed id 11037804)1, 2, 9 Guillemette C.... Housman D.E. (Pharmacogenetics 2000)
    7. UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis. (PubMed id 18054330)1, 4, 9 Tang K.S....Huang C.S. (Biochem. Biophys. Res. Commun. 2008)
    8. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer. (PubMed id 17406868)1, 4, 9 Fujita K....Sasaki Y. (Cancer Chemother. Pharmacol. 2007)
    9. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. (PubMed id 16199544)1, 4, 9 Verlaan M....Witt H. (J. Med. Genet. 2005)
    10. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. (PubMed id 12010889)1, 4, 9 Strassburg C.P....Manns M.P. (Gut 2002)
    11. Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer. (PubMed id 19360737)1, 4, 9 Lacko M....Manni J.J. (amp 2009)
    12. [Association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer]. (PubMed id 20193274)1, 4, 9 Liu J....Song D.K. (Zhonghua Yi Xue Za Zhi 2009)
    13. UGT1A7 haplotype is associated with an increased risk of hepatocellular carcinoma in hepatitis B carriers. (PubMed id 18271934)1, 4, 9 Kong S.Y....Kim J.W. (Cancer Sci. 2008)
    14. Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. (PubMed id 17529886)1, 4, 9 Inoue K....Suzuki T. (Ther Drug Monit 2007)
    15. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PubMed id 17072959)1, 4, 9 Piepoli A....Perri F. (World J. Gastroenterol. 2006)
    16. [Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer]. (PubMed id 16620591)1, 4, 9 Fan C.H....Chen K. (Zhonghua Yu Fang Yi Xue Za Zhi 2006)
    17. [Correlation of polymorphisms of UDP-glucuronosyltransferase 1A7 gene to genetic susceptibility of lung cancer]. (PubMed id 16159430)1, 4, 9 Feng F.Y....Lin D.X. (Ai Zheng 2005)
    18. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection. (PubMed id 15073122)1, 4, 9 Wang Y....Omata M. (Clin. Cancer Res. 2004)
    19. Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. (PubMed id 18349289)1, 4, 9 Lankisch T.O....Strassburg C.P. (amp 2008)
    20. Combined UGT1A1 and UGT1A7 variant alleles are associated with increased risk of Gilbert's syndrome in Taiwanese adults. (PubMed id 17850628)1, 4, 9 Teng H.C....Huang C.S. (Clin. Genet. 2007)
    21. UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. (PubMed id 12806614)1, 4, 9 Ockenga J....Strassburg C.P. (Gastroenterology 2003)
    22. Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. (PubMed id 9271343)1, 2, 9 Strassburg C.P.... Tukey R.H. (Mol. Pharmacol. 1997)
    23. Uridine diphosphoglucuronosyltransferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers. (PubMed id 19430315)1, 4, 9 Wang Y....Zheng Y. (J. Occup. Environ. Med. 2009)
    24. Polymorphism of UDP-glucuronosyltransferase 1A7 gene: a possible new risk factor for lung cancer. (PubMed id 16143514)1, 4, 9 Araki J....Adachi Y. (Eur. J. Cancer 2005)
    25. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. (PubMed id 15709193)1, 4, 9 Carlini L.E....Blanchard R.L. (Clin. Cancer Res. 2005)
    26. Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. (PubMed id 11677206)1, 4, 9 Vogel A....Strassburg C.P. (Gastroenterology 2001)
    27. Genetic polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population. (PubMed id 17479406)1, 4, 9 Gu S.Y....Xia Z.L. (J. Toxicol. Environ. Health Part A 2007)
    28. UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers? (PubMed id 18021430)1, 4, 9 StA1cker I....Pelletier G. (BMC Cancer 2007)
    29. Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population. (PubMed id 16724991)1, 4, 9 Chen K....Yao K. (J. Gastroenterol. Hepatol. 2006)
    30. Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. (PubMed id 15319294)1, 4, 9 van der Logt E.M....Peters W.H. (Carcinogenesis 2004)
    31. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. (PubMed id 19364970)1, 4, 9 Cecchin E....Toffoli G. (J. Clin. Oncol. 2009)
    32. Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers. (PubMed id 18597651)1, 4, 9 LAcvesque E....Guillemette C. (Pharmacogenomics 2008)
    33. DNA-repair and carcinogen-metabolising enzymes genetic polymorphisms as an independent risk factor for hepatocellular carcinoma in Caucasian liver-transplanted patients. (PubMed id 17870518)1, 4, 9 Borentain P....GAcrolami R. (Eur. J. Cancer 2007)
    34. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. (PubMed id 16636344)1, 4, 9 Han J.Y....Lee J.S. (J. Clin. Oncol. 2006)
    35. Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene. (PubMed id 16097053)1, 4, 9 Machida H....Wen C.Y. (World J. Gastroenterol. 2005)
    36. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. (PubMed id 19303655)1, 4, 9 Lankisch T.O....Strassburg C.P. (J. Hepatol. 2009)
    37. Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes. (PubMed id 15929176)1, 4, 9 Tang K.S....Huang C.S. (World J. Gastroenterol. 2005)
    38. UGT1A1 is a major locus influencing bilirubin levels in African Americans. (PubMed id 22085899)1, 4 Chen G....Rotimi C.N. (Eur. J. Hum. Genet. 2012)
    39. A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study. (PubMed id 22511988)1, 4 JylhAovAo J....Hurme M. (PLoS ONE 2012)
    40. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. (PubMed id 22558097)1, 4 Milton J.N....Klings E.S. (PLoS ONE 2012)
    41. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PubMed id 21646302)1, 4 Bielinski S.J....Chute C.G. (Mayo Clin. Proc. 2011)
    42. Human metabolic individuality in biomedical and pharmaceutical research. (PubMed id 21886157)1, 4 Suhre K....Gieger C. (Nature 2011)
    43. Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians. (PubMed id 20534012)1, 4 Sharma R....Khullar M. (Oral Dis 2010)
    44. Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele. (PubMed id 20565459)1, 4 Woillard J.B....Le Meur Y. (Br J Clin Pharmacol 2010)
    45. UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy. (PubMed id 20628391)1, 4 Martinez-Balibrea E....Moreno V. (Br. J. Cancer 2010)
    46. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    47. Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. (PubMed id 20567810)1, 4 Joy M.S....Smith P.C. (Eur. J. Clin. Pharmacol. 2010)
    48. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    49. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    50. Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)1, 4 Johnson A.D.... Witteman J.C. (Hum. Mol. Genet. 2009)
    51. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    52. Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. (PubMed id 19419973)1, 4 Sanna S....Uda M. (Hum. Mol. Genet. 2009)
    53. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. (PubMed id 19349540)1, 4 Innocenti F....Ratain M.J. (J. Clin. Oncol. 2009)
    54. Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. (PubMed id 18990750)1, 4 Cotterchio M....Harper P.A. (amp 2008)
    55. Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. (PubMed id 17558305)1, 4 Minami H....Saijo N. (Pharmacogenet. Genomics 2007)
    56. Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer. (PubMed id 12122597)1, 4 Vogel A....Strassburg C.P. (Z Gastroenterol 2002)
    57. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PubMed id 9295054)1, 3 Mackenzie P.I....Nebert D.W. (Pharmacogenetics 1997)
    58. UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls. (PubMed id 17325733)1, 9 te Morsche R.H....Witt H. (Pharmacogenomics J. 2008)
    59. Linkage disequilibrium of UGT1A1 *6 and UGT1A1 *28 in relation to UGT1A6 and UGT1A7 polymorphisms. (PubMed id 16969497)1, 9 Urawa N....Adachi Y. (Oncol. Rep. 2006)
    60. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. (PubMed id 12944498)1, 9 Villeneuve L.... Guillemette C. (J. Pharmacol. Exp. Ther. 2003)
    61. UGT1A1, UGT1A6 and UGT1A7 genetic analysis: repercussion for irinotecan pharmacogenetics in the SALo Miguel Island Population (Azores, Portugal). (PubMed id 19712005)1, 9 Pacheco P.R....Mota-Vieira L. (amp 2009)
    62. Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions. (PubMed id 19996319)1, 9 Bellemare J....Guillemette C. (J. Biol. Chem. 2010)
    63. Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. (PubMed id 18695635)1, 9 Miura M....Suzuki T. (Ther Drug Monit 2008)
    64. Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. (PubMed id 14557274)1, 9 Basu N.K....Owens I.S. (J. Biol. Chem. 2004)
    65. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. (PubMed id 20297805)1, 9 Tang L....Hu M. (Mol. Pharm. 2010)
    66. The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. (PubMed id 18556656)1, 9 Basu N.K....Owens I.S. (J. Biol. Chem. 2008)
    67. Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population. (PubMed id 18223459)1, 9 Yea S.S....Shin J.G. (Ther Drug Monit 2008)
    68. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. (PubMed id 18052087)1, 9 Joseph T.B....Hu M. (Mol. Pharm. 2007)
    69. A genome-wide assessment of variability in human serum metabolism. (PubMed id 23281178)1 Hong M.G....Prince J.A. (Hum. Mutat. 2013)
    70. A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. (PubMed id 23371916)1 Dai X....He M. (Genet. Epidemiol. 2013)
    71. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. (PubMed id 23642732)1 Cox A.J....Bowden D.W. (Atherosclerosis 2013)
    72. Association between polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and colorectal cancer risk. (PubMed id 22901212)1 Osawa K....Kido Y. (Asian Pac. J. Cancer Prev. 2012)
    73. The association between UGT1A7 polymorphism and cancer risk: a meta-analysis. (PubMed id 22402308)1 Han S.X....Wu D.Q. (Cancer Epidemiol 2012)
    74. Genotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited. (PubMed id 21440586)1 Vogel A....Strassburg C.P. (Gastroenterology 2011)
    75. Genetic polymorphisms of UGT1A7 and cancer risk: evidence from 21 case-control studies. (PubMed id 22085268)1 Lu P.H....Gu R.M. (Cancer Invest. 2011)
    76. Phase II study of a triplet regimen of S-1 combined with irinotecan and oxaliplatin in patients with metastatic gastric cancer: clinical and pharmacogenetic results. (PubMed id 20860988)1 Park S.R....Kim N.K. (Ann. Oncol. 2011)
    77. Genome-wide association of serum bilirubin levels in Korean population. (PubMed id 20639394)1 Kang T.W....Kim Y.S. (Hum. Mol. Genet. 2010)
    78. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    79. Assessment of UDP-glucuronosyltransferase catalyzed formation of ethyl glucuronide in human liver microsomes and recombinant UGTs. (PubMed id 16139098)6 Foti R.S. and Fisher M.B. (Forensic Sci. Int. 2005)
    80. Multiple variable first exons: a mechanism for cell- and tissue- specific gene regulation. (PubMed id 14672974)1 Zhang T.... Wu Q. (Genome Res. 2004)
    81. Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. (PubMed id 12732365)1 KAPhle C....Bock K.W. (Biochem. Pharmacol. 2003)
    82. Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. (PubMed id 12815363)4 Guillemette C. (Pharmacogenomics J. 2003)
    83. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    84. Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk. (PubMed id 11562393)1 Zheng Z....Lazarus P. (J. Natl. Cancer Inst. 2001)
    85. UDP-glucuronosyltransferases. (PubMed id 11465080)1 King C.D....Tephly T.R. (Curr. Drug Metab. 2000)
    86. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. (PubMed id 10836148)1 Tukey R.H. and Strassburg C.P. (Annu. Rev. Pharmacol. Toxicol. 2000)
    87. Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. (PubMed id 8467709)1 van Es H.H....Schurr E. (Cytogenet. Cell Genet. 1993)
    88. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. (PubMed id 9463278)9 Bruck M....Tukey R.H. (Arch. Biochem. Biophys. 1997)
    89. Differential protection by rat UDP-glucuronosyltransferase 1A7 against Benzo[a]pyrene-3,6-quinone- versus Benzo[a]pyrene-induced cytotoxic effects in human lymphoblastoid cells. (PubMed id 10631125)9 Grove A.D....Ritter J.K. (Toxicol. Appl. Pharmacol. 2000)
    90. Involvement of hepatocyte nuclear factor 1 in the regulation of the UDP-glucuronosyltransferase 1A7 (UGT1A7) gene in rat hepatocytes. (PubMed id 10908299)9 Metz R.P....Ritter J.K. (Mol. Pharmacol. 2000)
    91. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. (PubMed id 9264550)9 Bruck M....Tukey R.H. (Arch. Biochem. Biophys. 1997)
    92. Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. (PubMed id 15716465)9 Lankisch T.O....Strassburg C.P. (Mol. Pharmacol. 2005)
    93. Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. (PubMed id 10024527)9 Strassburg C.P....Tukey R.H. (Biochem. J. 1999)
    94. Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha. (PubMed id 15470081)9 Barbier O....Staels B. (Mol. Pharmacol. 2005)
    95. Glucuronidation of 3'-azido-3'-deoxythymidine catalyzed by human liver UDP-glucuronosyltransferase. Significance of nucleoside hydrophobicity and inhibition by xenobiotics. (PubMed id 1907149)9 Resetar A....Spector T. (Biochem. Pharmacol. 1991)
    96. Novel single nucleotide polymorphism of UGT1A7 gene in Japanese. (PubMed id 16547397)9 Fujita K....Sasaki Y. (Drug Metab. Pharmacokinet. 2006)
    97. Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity. (PubMed id 15845768)9 Basu N.K....Owens I.S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    98. Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. (PubMed id 15364550)9 Gregory P.A....Mackenzie P.I. (Toxicol. Appl. Pharmacol. 2004)
    99. Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes. (PubMed id 11929814)9 Fang J.L....Lazarus P. (Cancer Res. 2002)
    100. Glucuronidation of 1-hydroxypyrene by human liver microsomes and human UDP-glucuronosyltransferases UGT1A6, UGT1A7, and UGT1A9: development of a high-sensitivity glucuronidation assay for human tissue. (PubMed id 11454727)9 Luukkanen L....Elovaara E. (Drug Metab. Dispos. 2001)
    101. Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus. (PubMed id 10381366)9 Ciotti M....Owens I.S. (Biochem. Biophys. Res. Commun. 1999)
    102. Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. (PubMed id 9765507)9 Strassburg C.P....Tukey R.H. (Mol. Pharmacol. 1998)
    103. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. (PubMed id 9535849)9 Strassburg C.P.... Tukey R.H. (J. Biol. Chem. 1998)
    104. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. (PubMed id 20056724)9 Brand W....Rietjens I.M. (Drug Metab. Dispos. 2010)
    105. Key amino acid residues responsible for the differences in substrate specificity of human UDP-glucuronosyltransferase (UGT)1A9 and UGT1A8. (PubMed id 18832479)9 Fujiwara R....Yokoi T. (Drug Metab. Dispos. 2009)
    106. Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters. (PubMed id 19082692)9 Chu X.Y....Evers R. (Pharm. Res. 2009)
    107. Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. (PubMed id 18004212)9 Girard H....Guillemette C. (Pharmacogenet. Genomics 2007)
    108. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. (PubMed id 17179145)9 OperaA+a T.N. and Tukey R.H. (J. Biol. Chem. 2007)
    109. Hepatocyte nuclear factor1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4alpha. (PubMed id 17264800)9 Gardner-Stephen D.A. and Mackenzie P.I. (Pharmacogenet. Genomics 2007)
    110. Glucuronidation of thyroxine in human liver, jejunum, and kidney microsomes. (PubMed id 17591679)9 Yamanaka H....Yokoi T. (Drug Metab. Dispos. 2007)
    111. Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation. (PubMed id 16790555)9 Loureiro A.I....Soares-Da-Silva P. (Drug Metab. Dispos. 2006)
    112. Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. (PubMed id 15566942)9 Lampen A....Seidel A. (Biochim. Biophys. Acta 2004)
    113. UGT1A7 polymorphisms, polycyclic aromatic hydrocarbons and the development of hepatocellular cancer. (PubMed id 15382168)9 Kuchenbauer F....Beuers U. (Hepatology 2004)
    114. Multiple pharmacophores for the investigation of human UDP-glucuronosyltransferase isoform substrate selectivity. (PubMed id 14742671)9 Sorich M.J....Smith P.A. (Mol. Pharmacol. 2004)
    115. Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. (PubMed id 15117964)9 Basu N.K....Owens I.S. (J. Biol. Chem. 2004)
    116. Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. (PubMed id 12730278)9 Jinno H....Sawada J. (J. Pharmacol. Exp. Ther. 2003)
    117. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). (PubMed id 12181437)9 GagnAc J.F....Guillemette C. (Mol. Pharmacol. 2002)
    118. Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms. (PubMed id 12019188)9 Nakajima M....Yokoi T. (Drug Metab. Dispos. 2002)
    119. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. (PubMed id 11375903)9 Yueh M.F....Tukey R.H. (Carcinogenesis 2001)
    120. Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles: studies of human UDP-glucuronosyltransferases involved and substrate specificities. (PubMed id 11560872)9 Vashishtha S.C....McCann D.J. (Drug Metab. Dispos. 2001)
    121. Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. (PubMed id 11343231)9 Bachrich T....Penner E. (Hepatology 2001)
    122. AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms. (PubMed id 9762354)9 Bock K.W....Bock-Hennig B. (Adv. Enzyme Regul. 1998)
    123. Expression and inducibility of UDP-glucuronosyltransferases 1-naphthol in human cultured hepatocytes and hepatocarcinoma cell lines. (PubMed id 9180348)9 Abid A....Magdalou J. (Life Sci. 1997)
    124. Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases. (PubMed id 19850672)9 Liu Y....Ratain M.J. (Drug Metab. Dispos. 2010)
    125. Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids. (PubMed id 19339377)9 Mazur A....Moran J.H. (Drug Metab. Dispos. 2009)
    126. Comparative gene expression of intestinal metabolizing enzymes. (PubMed id 19746353)9 Shin H.C....Amidon G.L. (amp 2009)
    127. In silico and in vitro approaches to elucidate the thermal stability of human UDP-glucuronosyltransferase (UGT) 1A9. (PubMed id 19571435)9 Fujiwara R....Yokoi T. (Drug Metab. Pharmacokinet. 2009)
    128. Pharmacogenetic pathway analysis of irinotecan. (PubMed id 18418374)9 Rosner G.L....Ratain M.J. (Clin. Pharmacol. Ther. 2008)
    129. The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases. (PubMed id 18719240)9 ItAoaho K....Finel M. (Drug Metab. Dispos. 2008)
    130. Glucuronidation of tobacco-specific nitrosamines by UGT2B10. (PubMed id 18238858)9 Chen G....Lazarus P. (Drug Metab. Dispos. 2008)
    131. Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor. (PubMed id 17761779)9 Omura K....Nagata O. (Drug Metab. Dispos. 2007)
    132. In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. (PubMed id 17701830)9 Lee H.S....Kim S.Y. ( the fate of foreign compounds in biological systems 2007)
    133. Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk. (PubMed id 17436274)9 Ralph D.A....Jupe E.R. (Cancer 2007)
    134. Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. (PubMed id 17664247)9 Sun D....Lazarus P. (Drug Metab. Dispos. 2007)
    135. Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype. (PubMed id 17058217)9 Lankisch T.O....Strassburg C.P. (Hepatology 2006)
    136. Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4. (PubMed id 16480962)9 Ogura K....Hiratsuka A. (Biochem. Pharmacol. 2006)
    137. Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. (PubMed id 16609363)9 Boyd M.A....Miners J.O. (Pharmacogenet. Genomics 2006)
    138. Determination of drug glucuronidation and UDP-glucuronosyltransferase selectivity using a 96-well radiometric assay. (PubMed id 15788539)9 Di Marco A....Laufer R. (Drug Metab. Dispos. 2005)
    139. Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)- 5-(2-furyl)-4-oxazoleacetic acid (TA-1801A). (PubMed id 15988124)9 Kaji H. and Kume T. (Drug Metab. Pharmacokinet. 2005)
    140. UDP-glucuronosyltransferases and clinical drug-drug interactions. (PubMed id 15781124)9 Kiang T.K....Chang T.K. (amp 2005)
    141. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. (PubMed id 16399343)9 Bock K.W. and KAPhle C. (Meth. Enzymol. 2005)
    142. Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform. (PubMed id 15608137)9 Kaji H. and Kume T. (Drug Metab. Dispos. 2005)
    143. Amino acid residue ILE211 is essential for the enzymatic activity of human UDP-glucuronosyltransferase 1A10 (UGT1A10). (PubMed id 15039300)9 Martineau I....BAclanger A. (Drug Metab. Dispos. 2004)
    144. Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (PubMed id 15247627)9 Verlaan M....Drenth J.P. (Pharmacogenetics 2004)
    145. Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract. (PubMed id 15535975)9 Sabolovic N....Magdalou J. (Biochim. Biophys. Acta 2004)
    146. Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro. (PubMed id 15310245)9 Malfatti M.A. and Felton J.S. (Chem. Res. Toxicol. 2004)
    147. Analysis of double-stranded DNA by microchip capillary electrophoresis using polymer solutions containing gold nanoparticles. (PubMed id 14558611)9 Lin Y.W....Chang H.T. (J Chromatogr A 2003)
    148. [Pharmacogenomic approaches for prevention of drug toxicity in cancer chemotherapy]. (PubMed id 12669388)9 Hasegawa Y. (amp 2003)

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    Entrez Gene: 54577 HGNC: 12539 AceView: UGT1A1 Ensembl:ENSG00000244122 euGenes: HUgn54577
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