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UGT1A7 Gene

protein-coding   GIFtS: 50
GCID: GC02P234581

UDP Glucuronosyltransferase 1 Family, Polypeptide A7

(Previous names: UDP glycosyltransferase 1 family, polypeptide A6)
  See UGT1A7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A71 2     UDP Glycosyltransferase 1 Family, Polypeptide A61
UGT-1G2 3     UDPGT2
UGT1-072 3     UDP Glycosyltransferase 1 Family, Polypeptide A72
UGT1.72 3     UDP-Glucuronosyltransferase 1 Family Polypeptide A7s2
UGT1G2 3     UDP-Glucuronosyltransferase 1-72
UDP-Glucuronosyltransferase 1-G2 3     GNT13
UDP-Glucuronosyltransferase 1A72 3     UGT13
UDPGT 1-72 3     UGT1*73
EC 2.4.1.173 8     

External Ids:    HGNC: 125391   Entrez Gene: 545772   Ensembl: ENSG000002441227   OMIM: 6064325   UniProtKB: Q9HAW73   

Export aliases for UGT1A7 gene to outside databases

Previous GC identifers: GC02U990247 GC02P234820 GC02P234883 GC02P234368 GC02P234372 GC02P234198 GC02P234209 GC02P234218 GC02P234255 GC02P226390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UGT1A7 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate
glucuronidase activity with phenols. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A7 Gene:
UGT1A7 (UDP glucuronosyltransferase 1 family, polypeptide A7) is a protein-coding gene. Diseases associated with UGT1A7 include bilirubin metabolic disorder, and kernicterus. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds

Gene Wiki entry for UGT1A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the UGT1A7 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   COUP   HNF-4alpha2   PPAR-gamma2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UGT1A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT1A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234581:  view genomic region     (about GC identifiers)

Start:
234,590,584 bp from pter      End:
234,681,945 bp from pter
Size:
91,362 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-7 precursor  
Size: 530 amino acids; 59819 Da
Secondary accessions: O00473
Alternative splicing: 1 isoform:  Q9HAW7-1   

Explore the universe of human proteins at neXtProt for UGT1A7: NX_Q9HAW7

Explore proteomics data for UGT1A7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn292, Asn344
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGT1A7 (Q9HAW7) (see all 25)
     PEVSWQL  FWVEFVM  GIFCHYL  WLLRTDF 


    See UGT1A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061950.2  
    ENSEMBL proteins: 
     ENSP00000362525   ENSP00000420181  
    Reactome Protein details: Q9HAW7

    UGT1A7 Human Recombinant Protein Products:

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    antibodies-online peptides for UGT1A7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q9HAW7

    ProtoNet protein and cluster: Q9HAW7

    2 Blocks protein domains:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase


    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Similarity: Belongs to the UDP-glycosyltransferase family


    Find genes that share domains with UGT1A7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD17_HUMAN, Q9HAW7
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA--
    GO:0004857enzyme inhibitor activity IDA19996319
    GO:0005080protein kinase C binding IPI18556656
    GO:0008144drug binding IDA--
    GO:0015020glucuronosyltransferase activity IDA18052087
         
    Find genes that share ontologies with UGT1A7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT1A7:
     Synthetic lethal with imatinib 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UGT1A7

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate UGT1A7:
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    GenScript: all cDNA clones in your preferred vector: UGT1A7 (NM_019077)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UD17_HUMAN, Q9HAW7: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    golgi apparatus2
    nucleus2
    peroxisome2
    plasma membrane2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18556656
    GO:0005789endoplasmic reticulum membrane NAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UGT1A7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGT1A7 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    Glucuronidation0.00
    3Metabolism of porphyrins
    Metabolism of porphyrins0.56
    Heme degradation0.00
    Porphyrin and chlorophyll metabolism0.56
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    5Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35


    Find genes that share SuperPaths with UGT1A7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UGT1A7
        Glucuronidation
    metapathway biotransformation

    1 Reactome Pathway for UGT1A7
        Glucuronidation

    1 PharmGKB Pathway for UGT1A7
        Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for UGT1A7) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UGT1A7
    Interactions:

        GeneGlobe Interaction Network for UGT1A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT1A7 (ENSP000003625254) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH6ENSP000003783594STRING: ENSP00000378359
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0007588excretion IC--
    GO:0008152metabolic process ----
    GO:0009804coumarin metabolic process IC19996319
    GO:0017144drug metabolic process IDA--

    Find genes that share ontologies with UGT1A7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT1A7 (UD17)

    84 HMDB Compounds for UGT1A7 (see first 10)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ethyl glucuronide 17685-04-016139098
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----
    17-beta-estradiol glucuronide ----
    17-beta-estradiol-3-glucuronideEstradiol glucuronide (see all 13)----
    17-hydroxyandrostane-3-glucuronide(3alpha,5alpha,17beta)-17-hydroxyandrostan-3-yl-beta-D-Glucopyranosiduronic acid (see all 4)65535-18-4--
    2-Methoxy-estradiol-17b 3-glucuronide2-Methoxy-estradiol-17beta 3-glucuronide ----
    2-Methoxyestradiol2-Methoxyestradiol 362-07-2--
    2-Methoxyestrone2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one (see all 7)362-08-3--
    2-Methoxyestrone 3-glucuronide2-Methoxyestrone-3-glucuronide (see all 2)25577-70-2--
    2-Phenylethanol glucuronide2-phenylethanol glucuronoside ----
    25-Hydroxyvitamin D2 25-(beta-glucuronide)25-hydroxyvitamine D2 25-(beta-glucuronoside) ----
    25-Hydroxyvitamin D2-25-glucuronide25-hydroxyvitamin D2-25-glucuronoside (see all 4)----
    3,17-Androstanediol glucuronide ----
    3-Methoxy-4-hydroxyphenylglycol glucuronide3-Methoxy-4-hydroxyphenylglycol glucuronide (see all 2)52002-41-2--
    3-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide5beta-Pregnane-3alpha,20alpha-diol glucuronide (see all 2)----
    3-alpha-androstanediol glucuronideAndrostane-3alpha,17beta-diol 3-D-glucuronide (see all 2)----
    3-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide3alpha-hydroxy-5alpha-androstane-17-one 3-D-glucuronoside (see all 2)----
    4-Hydroxyandrostenedione glucuronide ----
    5-Hydroxy-6-methoxyindole glucuronide6-methoxy-1H-indol-5-yl-beta-D-Glucopyranosiduronic acid (see all 3)77463-71-9--
    5-alpha-Dihydrotestosterone glucuronideDihydrotestosterone glucuronide (see all 5)42037-24-1--
    6-Dehydrotestosterone glucuronide6-dehydrotestosterone O-glucuronide (see all 5)----
    6-Hydroxy-5-methoxyindole glucuronide5-Methoxyindol-6-yl D-glucosiduronic acid (see all 4)77463-72-0--
    Aldosterone 18-glucuronideAldosterone-18-D-glucosiduronic acid (see all 6)3604-86-2--
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-8--
    Androsterone glucuronide3a-Hydroxy-5a-androstan-17-one glucuronide (see all 8)1852-43-3--
    Benzoyl glucuronide (Benzoic acid) 19237-53-7--
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-4--
    Bilirubin diglucuronide(2S,3S,4S,5R,6S)-6-[3-[2-[[3-[2-[(2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxycarbonylethyl]-5-[(E)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(E)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoyloxy]-3,4,5-trihydroxy-oxane-2-carboxylate (see all 5)17459-92-6--
    Bilirubin glucuronidebilirubin glucuronate (see all 10)----
    Cholestane-3,7,12,25-tetrol-3-glucuronide5beta-Cholestane 3alpha,7alpha,12alpha,25-tetrol-3alpha-glucuronide (see all 5)77172-80-6--
    Cholesterol glucuronideCholest-5-en-3beta-yl beta-D-glucopyranosiduronic acid (see all 8)17435-78-8--
    Cholic acid glucuronide7,12-dihydroxy-3-o-(beta-d-glucopyranosyluronate)-5beta-cholan-24-oate (see all 6)76060-22-5--
    Codeine(-)-Codeine (see all 9)76-57-3--
    Cortolone-3-glucuronide20alpha-Cortolone-3-glucuronide (see all 2)56162-46-0--
    Cotinineglucuronidecotinine-glucuronide (see all 4)139427-57-9--
    Dehydroepiandrosterone 3-glucuronide3-(glucuronide)-(3-beta)-androst-5-en-17-one (see all 3)3331-64-4--
    Dehydroisoandrosterone 3-glucuronide ----
    Deoxycholic acid 3-glucuronideDeoxycholic acid 3-glucuronide 72504-58-6--
    Dextrorphan O-glucuronidedextrorphan O-glucuronoside (see all 3)----
    Dopamine glucuronide4-(2-aminoethyl)-2-hydroxyphenyl beta-D-glucopyranosiduronic acid (see all 5)38632-24-5--
    Epinephrine glucuronide2-hydroxy-4-[1-hydroxy-2-(methylamino)ethyl]phenyl beta-D-Glucopyranosiduronic acid (see all 4)54964-61-3--
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--
    Estriol13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol (see all 50)50-27-1--
    Estriol 3-sulfate 16-glucuronideEstriol 3-sulfate 16alpha-glucuronide (see all 6)4661-65-8--
    Estriol-16-Glucuronide16alpha,17beta-Estriol 16-(beta-D-glucuronide) (see all 3)1852-50-2--
    Estriol-17-glucuronide(16alpha,17beta)-3,16-dihydroxyestra-1,3,5(10)-trien-17-yl beta-D-glucopyranosiduronic acid (see all 13)7219-89-8--
    Estriol-3-glucuronide16alpha,17beta-Dihydroxyestra-1,3,5(10)-trien-3-yl-glucopyranosiduronic acid (see all 14)2479-91-6--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone glucuronideEstrone 3-glucuronide (see all 4)2479-90-5--
    Etiocholanolone3a-Etiocholanolone (see all 12)53-42-9--
    Etiocholanolone glucuronideEtiocholan-3alpha-ol-17-one 3-glucuronoside (see all 10)3602-09-3--
    Glycochenodeoxycholic acid 3-glucuronideGlycochenodeoxycholic acid 3-glucuronide 79254-98-1--
    Inodxyl glucuronide ----
    IsovalerylglucuronideIsovaleryl-beta-D-glucuronide (see all 2)88070-93-3--
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-3--
    Lithocholate 3-O-glucuronideLithocholic acid 3-O-glucuronide (see all 2)75239-91-7--
    Nicotine glucuronide(S)-1-alpha-D-glucopyranuronosyl-3-(1-methyl-2-pyrrolidinyl)-Pyridinium inner salt (see all 11)152306-59-7--
    OctanoylglucuronideOctanoyl-beta-D-glucuronide (see all 5)99910-55-1--
    Palmitoyl glucuronidePglcua (see all 6)----
    Phenethylamine glucuronide ----
    Pregnanediol-3-glucuronide ----
    Retinoic acidRetinoate (see all 21)302-79-4--
    Retinoyl b-glucuronide13-cis-Retinoyl glucuronide (see all 21)401-10-5--
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)----
    Testosterone(+)-testosterone (see all 86)58-22-0--
    Testosterone glucuronide(17b)-3-oxoandrost-4-en-17-yl b-D-Glucopyranosiduronic acid (see all 11)1180-25-2--
    Testosterone sulfate17-O-Sulfotestosterone (see all 10)651-45-6--
    Tetrahydroaldosterone-3-glucuronideTetrahydroaldosterone-3-glucuronoside (see all 6)20605-81-6--
    Thyroxine glucuronidebeta-D 4-[4-(L-2-amino-2-carboxyethyl)-2,6-diiodophenoxy]-2,6-diiodophenyl glucopyranosiduronic acid (see all 7)21462-56-6--
    Triiodothyronine glucuronide(S)-4-(4-(2-amino-2-carboxyethyl)-2,6-diiodophenoxy)-2-iodophenyl-beta-D-Glucopyranosiduronic acid (see all 3)29919-72-0--
    Tyramine glucuronide4-(2-Aminoethyl)phenyl-beta-D-glucopyranosiduronic acid (see all 2)27972-85-6--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    Valproic acid glucuronide1-(2-propylpentanoate) beta-D-Glucopyranuronate (see all 18)60113-83-9--
    Vitamin D2 3-glucuronidevitamin D2 glucosiduronate (see all 4)----
    trans-3-Hydroxycotinine glucuronide3'-Hydroxycotnine-glucuronide (see all 3)132929-88-5--

    Selected Novoseek inferred chemical compound relationships for UGT1A7 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uridine diphosphate 80 4 16724991 (1), 12669388 (1), 16097053 (1)
    sn 38 79.4 4 12944498 (2), 18349289 (2)
    sn38 glucuronide 76.2 3 18418374 (1), 12181437 (1)
    glucuronide 73.4 2 9762354 (1), 11560872 (1)
    n-hydroxy phip 70.7 3 15310245 (1), 11375903 (1)
    irinotecan 66.5 15 18349289 (3), 15709193 (2), 12944498 (2), 19712005 (2) (see all 9)
    glucuronic acid 59.8 2 16159430 (1)
    flavopiridol 59.3 1 12944498 (1)
    uridine 58.8 3 17529886 (1), 16636344 (1), 17436274 (1)
    mycophenolic acid 53 7 17529886 (5), 18695635 (1)

    1 PharmGKB related drug/compound annotation for UGT1A7 gene    About this table
    Drug/compound PharmGKB Annotation
    valproic acidCA  



    Find genes that share compounds with UGT1A7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for UGT1A7 gene: 
    NM_019077.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373426(uc010zmx.1 uc002vut.3) ENST00000485022
    miRNA
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    Selected AceView cDNA sequences (see all 271):

    AY435141 CB162031 BE464379 BE464422 BC053576 BI764371 AI479279 BG165230 
    AI767337 NM_019077 NM_205862 AY435136 CB163341 BE464186 NM_019093 AY435143 
    BE463503 AU076863 NM_019076 AV646429 AW297730 BC043491 AV650286 NM_001072 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UGT1A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A7 Expression
    About this image

    UGT1A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT1A7 Protein Expression

    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Tissue specificity: Liver and gastric tissue

        Custom PCR Arrays for UGT1A7
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A7 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a91 UDP glucuronosyltransferase 1 family, polypeptide A9 81.44(n)
    80.98(a)
      394434  NM_201644.2  NP_964006.2 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    59(a)
    42(a)
    many ↔ many
    many ↔ many
    7(5735050-5897491)
    7(5872756-5873724)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    many ↔ many
    6(58626676-58649813)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1a76
    ugt1b46
    (see all 6)
    UDP glucuronosyltransferase 1 family, polypeptide ...
    UDP glucuronosyltransferase 1 family, polypeptide ...
    (see all 6)
    49(a)
    46(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    9(10194767-10228491) ENSDARG00000006220
    11(31182060-31204509) ENSDARG00000097024


    ENSEMBL Gene Tree for UGT1A7 (if available)
    TreeFam Gene Tree for UGT1A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGT1A7 gene
    UGT1A81 2  UGT1A101 2  UGT1A91 2  UGT2A22  UGT3A12  UGT2B112  UGT2B72  UGT1A32  
    UGT1A12  UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A62  UGT82  UGT2B152  
    UGT2B42  UGT2A32  UGT2B172  UGT2B282  UGT1A42  
    Selected SIMAP similar genes for UGT1A7 using alignment to 16 protein entries:     UD17_HUMAN (see all proteins) (see all similar genes):
    UGT1G    UGT1A8S    UGT1A9S    UGT1A10    UGT1J    UGT1A8
    UGT1A3S    UGT1H    UGT1A9    UGT1A6    UGT1A6S    UGT2B17
    BILIQTL1    UGT1A1    UGT1    UGT2B28    UGT2B11    UGT1A4S

    Find genes that share paralogs with UGT1A7           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for UGT1A7
    PGOHUM00000241145 PGOHUM00000241146


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    UD17_HUMAN, Q9HAW7: There are four common allelic UGT1A7 variants which exhibit significant differences in catalytic
    activity towards 3-, 7-, and 9-hydroxy-benzo(a)pyrene. UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared
    to UGT1A7*1, whereas UGT1A7*2 and UGT1A7*4 have a 2.6- and 2.8-fold lower relative Vmax than UGT1A7*1,
    respectively, suggesting that these mutations confer slow glucuronidation phenotype


    4 SNPs for UGT1A7    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0155574
    ----see VAR_0155572 R K mis40--------
    rs178683241,2,4
    ----see VAR_0524622 mis40--------
    rs116920211,2,4
    ----see VAR_0155582 mis40--------
    rs178683231,2,4
    ----see VAR_0155562 mis40--------

    HapMap Linkage Disequilibrium report for UGT1A7 (234590584 - 234681945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGT1A7 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2661542CNV Deletion23128226
    esv2721667CNV Deletion23290073
    esv2721666CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721669CNV Deletion23290073
    esv2721668CNV Deletion23290073
    nsv514125CNV Loss21397061
    nsv433211CNV Loss18776910
    nsv498958CNV Loss21111241

    Human Gene Mutation Database (HGMD): UGT1A7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT1A7
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606432    OMIM disorders: --

    5 diseases for UGT1A7:    
    About MalaCards
    bilirubin metabolic disorder    kernicterus    sickle cell anemia    pancreatic cancer
    hepatocellular carcinoma

    2 diseases from the University of Copenhagen DISEASES database for UGT1A7:
    Bilirubin metabolic disorder     Kernicterus

    Find genes that share disorders with UGT1A7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for UGT1A7 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gilberts syndrome 74.9 5 18349289 (3), 19303655 (1), 17850628 (1)
    pancreatic diseases 49.6 2 12806614 (1), 16199544 (1)
    hyperbilirubinemia 36.2 1 19303655 (1)
    hepatocellular carcinoma 35.3 16 11677206 (3), 18271934 (3), 15073122 (2), 15382168 (1) (see all 8)
    colorectal cancer 33.5 12 16620591 (4), 12010889 (1), 15709193 (1), 19364970 (1) (see all 6)
    chronic pancreatitis 32.3 4 16199544 (2), 12806614 (1), 17325733 (1)
    genetic susceptibility 15.1 3 16159430 (2), 16724991 (1)
    cancer 13 7 11677206 (2), 17406868 (2), 12010889 (1), 16620591 (1) (see all 5)
    hepatitis c 12.8 4 11343231 (1), 18054330 (1), 15073122 (1), 16086712 (1)
    pancreatic cancer 12.8 7 16199544 (4), 17072959 (2), 12806614 (1)

    Genetic Association Database (GAD): UGT1A7
    Human Genome Epidemiology (HuGE) Navigator: UGT1A7 (57 documents)

    Export disorders for UGT1A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGT1A7 gene, integrated from 10 sources (see all 154):
    (articles sorted by number of sources associating them with UGT1A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)1, 2, 4, 9 Menard V.... Guillemette C. (Hum. Mutat. 2009)
    2. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)1, 2, 3, 9 Gong Q.H.... Popescu N.C. (Pharmacogenetics 2001)
    3. Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer. (PubMed id 16030093)1, 4, 9 Butler L.M....Guillemette C. (amp 2005)
    4. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. (PubMed id 16086712)1, 4, 9 Tseng C.S....Huang C.S. (Am. J. Gastroenterol. 2005)
    5. Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. (PubMed id 15682470)1, 4, 9 Huang M.J....Huang C.S. (World J. Gastroenterol. 2005)
    6. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. (PubMed id 11037804)1, 2, 9 Guillemette C.... Housman D.E. (Pharmacogenetics 2000)
    7. UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis. (PubMed id 18054330)1, 4, 9 Tang K.S....Huang C.S. (Biochem. Biophys. Res. Commun. 2008)
    8. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer. (PubMed id 17406868)1, 4, 9 Fujita K....Sasaki Y. (Cancer Chemother. Pharmacol. 2007)
    9. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. (PubMed id 16199544)1, 4, 9 Verlaan M....Witt H. (J. Med. Genet. 2005)
    10. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. (PubMed id 12010889)1, 4, 9 Strassburg C.P....Manns M.P. (Gut 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54577 HGNC: 12539 AceView: UGT1A1 Ensembl:ENSG00000244122 euGenes: HUgn54577
    ECgene: UGT1A7 Kegg: 54577 H-InvDB: UGT1A7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UGT1A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UGT1A7 gene:
    Search GeneIP for patents involving UGT1A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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