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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT1A7 Gene

protein-coding   GIFtS: 49
GCID: GC02P234581

UDP glucuronosyltransferase 1 family, polypeptide A7

(Previous names: UDP glycosyltransferase 1 family, polypeptide A6 )
 Explore 29 diseases affiliated with
UGT1A7 via
MalaCards
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 Human Malady Compendium 
Biological research products
for UGT1A7    

Aliases
for UGT1A7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A71 2     UDP Glycosyltransferase 1 Family, Polypeptide A61
UGT1G1 2 3     UDPGT2
UGT-1G2 3     UDP Glycosyltransferase 1 Family, Polypeptide A72
UGT1-072 3     UDP-Glucuronosyltransferase 1 Family Polypeptide A7s2
UGT1.72 3     UDP-Glucuronosyltransferase 1-72
UDP-Glucuronosyltransferase 1-G2 3     GNT13
UDP-Glucuronosyltransferase 1A72 3     UGT13
UDPGT 1-72 3     UGT1*73
EC 2.4.1.173 8     

External Ids:    HGNC: 125391   Entrez Gene: 545772   Ensembl: ENSG000002441227   OMIM: 6064325   UniProtKB: Q9HAW73   

Export aliases for UGT1A7 gene to outside databases

Previous GC identifers: GC02U990247 GC02P234820 GC02P234883 GC02P234368 GC02P234372 GC02P234198 GC02P234209 GC02P234218 GC02P234255 GC02P226390


Summaries
for UGT1A7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UGT1A7:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen
unique alternate first exons followed by four common exons. Four of the alternate first exons are considered
pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins
with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated
by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds

Gene Wiki entry for UGT1A7


Genomic Views
for UGT1A7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT1A7 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   COUP   HNF-4alpha2   PPAR-gamma2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UGT1A7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234581:  view genomic region     (about GC identifiers)

Start:
 234,590,584 bp from pter      End:
 234,681,945 bp from pter
Size:
 91,362 bases      Orientation:
 plus strand

Proteins
for UGT1A7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-7 precursor  
Size: 530 amino acids; 59819 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Secondary accessions: O00473
Alternative splicing: 1 isoform:  Q9HAW7-1   

Explore the universe of human proteins at neXtProt for UGT1A7: NX_Q9HAW7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HAW7

    • 4/25 DME Specific Peptides for UGT1A7 (Q9HAW7) (see all 25)
     PEVSWQL  FWVEFVM  GIFCHYL  WLLRTDF 

    UGT1A7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061950.2  
    ENSEMBL proteins: 
     ENSP00000362525   ENSP00000420181  
    Reactome Protein details: Q9HAW7
    Human Recombinant Protein Products: 
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    Uscn Proteins for UGT1A7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18556656
    GO:0005789endoplasmic reticulum membrane NAS--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--


    UGT1A7 for ontologies           About GeneDecksing



    UGT1A7 Antibody Products: 
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    Assay Products for UGT1A7: 
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    Uscn ELISAs and CLIAs for UGT1A7

    Protein Domains /
    Families
    for UGT1A7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UGT1A7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q9HAW7

    ProtoNet protein and cluster: Q9HAW7

    2 Blocks protein families:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase


    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Similarity: Belongs to the UDP-glycosyltransferase family


    Function
    for UGT1A7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
    and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

    Enzyme Number (IUBMB): EC 2.4.1.171 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UGT1A7
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate UGT1A7:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: UGT1A7
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UGT1A7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A7 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A7

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA--
    GO:0004857enzyme inhibitor activity IDA--
    GO:0005080protein kinase C binding IPI18556656
    GO:0008144drug binding IDA--
    GO:0015020glucuronosyltransferase activity IDA--


    UGT1A7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UGT1A7:
     Synthetic lethal with imatinib 


    Pathways & Interactions
    for UGT1A7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    		Glucuronidation1.00
    		Porphyrin and chlorophyll metabolism0.38
    		Glucuronidation0.67
    		Other types of O-glycan biosynthesis0.36
    		Starch and sucrose metabolism0.42
    		Drug metabolism - other enzymes0.32
    2Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Retinol metabolism0.40
    		Metabolism of xenobiotics by cytochrome P4500.73
    3Biological oxidations
    		Biological oxidations1.00
    		metapathway biotransformation0.41
    		Phase II conjugation0.52
    4Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    5Pentose and glucuronate interconversions
    		Pentose and glucuronate interconversions1.00
    		Ascorbate and aldarate metabolism0.62

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for UGT1A7 
        Glucuronidation
    metapathway biotransformation

    4        Reactome Pathways for UGT1A7
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation

    1 PharmGKB Pathway for UGT1A7
        Mycophenolic acid Pathway, Pharmacokinetics

    5/11         Kegg Pathways  (Kegg details for UGT1A7) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Other types of O-glycan biosynthesis


    UGT1A7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT1A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT1A7 (ENSP000003625254) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    BLVRAENSP000002655234STRING: ENSP00000265523
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007588excretion IC--
    GO:0009804coumarin metabolic process IC19996319
    GO:0017144drug metabolic process IDA--
    GO:0042573retinoic acid metabolic process IC--
    GO:0043086negative regulation of catalytic activity IDA--


    UGT1A7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UGT1A7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT1A7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT1A7

    84 HMDB Compounds for UGT1A7 (see first 10)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ethyl glucuronide 17685-04-016139098
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----
    17-beta-estradiol glucuronide ----
    17-beta-estradiol-3-glucuronideEstradiol glucuronide (see all 13)----
    17-hydroxyandrostane-3-glucuronide(3alpha,5alpha,17beta)-17-hydroxyandrostan-3-yl-beta-D-Glucopyranosiduronic acid (see all 4)65535-18-4--
    2-Methoxy-estradiol-17b 3-glucuronide2-Methoxy-estradiol-17beta 3-glucuronide ----
    2-Methoxyestradiol2-Methoxyestradiol 362-07-2--
    2-Methoxyestrone2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one (see all 7)362-08-3--
    2-Methoxyestrone 3-glucuronide2-Methoxyestrone-3-glucuronide (see all 2)25577-70-2--
    2-Phenylethanol glucuronide2-phenylethanol glucuronoside ----
    25-Hydroxyvitamin D2 25-(beta-glucuronide)25-hydroxyvitamine D2 25-(beta-glucuronoside) ----
    25-Hydroxyvitamin D2-25-glucuronide25-hydroxyvitamin D2-25-glucuronoside (see all 4)----
    3,17-Androstanediol glucuronide ----
    3-Methoxy-4-hydroxyphenylglycol glucuronide3-Methoxy-4-hydroxyphenylglycol glucuronide (see all 2)52002-41-2--
    3-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide5beta-Pregnane-3alpha,20alpha-diol glucuronide (see all 2)----
    3-alpha-androstanediol glucuronideAndrostane-3alpha,17beta-diol 3-D-glucuronide (see all 2)----
    3-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide3alpha-hydroxy-5alpha-androstane-17-one 3-D-glucuronoside (see all 2)----
    4-Hydroxyandrostenedione glucuronide ----
    5-Hydroxy-6-methoxyindole glucuronide6-methoxy-1H-indol-5-yl-beta-D-Glucopyranosiduronic acid (see all 3)77463-71-9--
    5-alpha-Dihydrotestosterone glucuronideDihydrotestosterone glucuronide (see all 5)42037-24-1--
    6-Dehydrotestosterone glucuronide6-dehydrotestosterone O-glucuronide (see all 5)----
    6-Hydroxy-5-methoxyindole glucuronide5-Methoxyindol-6-yl D-glucosiduronic acid (see all 4)77463-72-0--
    Aldosterone 18-glucuronideAldosterone-18-D-glucosiduronic acid (see all 6)3604-86-2--
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-8--
    Androsterone glucuronide3a-Hydroxy-5a-androstan-17-one glucuronide (see all 8)1852-43-3--
    Benzoyl glucuronide (Benzoic acid) 19237-53-7--
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-4--
    Bilirubin diglucuronide(2S,3S,4S,5R,6S)-6-[3-[2-[[3-[2-[(2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxycarbonylethyl]-5-[(E)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(E)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoyloxy]-3,4,5-trihydroxy-oxane-2-carboxylate (see all 5)17459-92-6--
    Bilirubin glucuronidebilirubin glucuronate (see all 10)----
    Cholestane-3,7,12,25-tetrol-3-glucuronide5beta-Cholestane 3alpha,7alpha,12alpha,25-tetrol-3alpha-glucuronide (see all 5)77172-80-6--
    Cholesterol glucuronideCholest-5-en-3beta-yl beta-D-glucopyranosiduronic acid (see all 8)17435-78-8--
    Cholic acid glucuronide7,12-dihydroxy-3-o-(beta-d-glucopyranosyluronate)-5beta-cholan-24-oate (see all 6)76060-22-5--
    Codeine(-)-Codeine (see all 9)76-57-3--
    Cortolone-3-glucuronide20alpha-Cortolone-3-glucuronide (see all 2)56162-46-0--
    Cotinineglucuronidecotinine-glucuronide (see all 4)139427-57-9--
    Dehydroepiandrosterone 3-glucuronide3-(glucuronide)-(3-beta)-androst-5-en-17-one (see all 3)3331-64-4--
    Dehydroisoandrosterone 3-glucuronide ----
    Deoxycholic acid 3-glucuronideDeoxycholic acid 3-glucuronide 72504-58-6--
    Dextrorphan O-glucuronidedextrorphan O-glucuronoside (see all 3)----
    Dopamine glucuronide4-(2-aminoethyl)-2-hydroxyphenyl beta-D-glucopyranosiduronic acid (see all 5)38632-24-5--
    Epinephrine glucuronide2-hydroxy-4-[1-hydroxy-2-(methylamino)ethyl]phenyl beta-D-Glucopyranosiduronic acid (see all 4)54964-61-3--
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--
    Estriol13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol (see all 50)50-27-1--
    Estriol 3-sulfate 16-glucuronideEstriol 3-sulfate 16alpha-glucuronide (see all 6)4661-65-8--
    Estriol-16-Glucuronide16alpha,17beta-Estriol 16-(beta-D-glucuronide) (see all 3)1852-50-2--
    Estriol-17-glucuronide(16alpha,17beta)-3,16-dihydroxyestra-1,3,5(10)-trien-17-yl beta-D-glucopyranosiduronic acid (see all 13)7219-89-8--
    Estriol-3-glucuronide16alpha,17beta-Dihydroxyestra-1,3,5(10)-trien-3-yl-glucopyranosiduronic acid (see all 14)2479-91-6--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone glucuronideEstrone 3-glucuronide (see all 4)2479-90-5--
    Etiocholanolone3a-Etiocholanolone (see all 12)53-42-9--
    Etiocholanolone glucuronideEtiocholan-3alpha-ol-17-one 3-glucuronoside (see all 10)3602-09-3--
    Glycochenodeoxycholic acid 3-glucuronideGlycochenodeoxycholic acid 3-glucuronide 79254-98-1--
    Inodxyl glucuronide ----
    IsovalerylglucuronideIsovaleryl-beta-D-glucuronide (see all 2)88070-93-3--
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-3--
    Lithocholate 3-O-glucuronideLithocholic acid 3-O-glucuronide (see all 2)75239-91-7--
    Nicotine glucuronide(S)-1-alpha-D-glucopyranuronosyl-3-(1-methyl-2-pyrrolidinyl)-Pyridinium inner salt (see all 11)152306-59-7--
    OctanoylglucuronideOctanoyl-beta-D-glucuronide (see all 5)99910-55-1--
    Palmitoyl glucuronidePglcua (see all 6)----
    Phenethylamine glucuronide ----
    Pregnanediol-3-glucuronide ----
    Retinoic acidRetinoate (see all 21)302-79-4--
    Retinoyl b-glucuronide13-cis-Retinoyl glucuronide (see all 21)401-10-5--
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)----
    Testosterone(+)-testosterone (see all 86)58-22-0--
    Testosterone glucuronide(17b)-3-oxoandrost-4-en-17-yl b-D-Glucopyranosiduronic acid (see all 11)1180-25-2--
    Testosterone sulfate17-O-Sulfotestosterone (see all 10)651-45-6--
    Tetrahydroaldosterone-3-glucuronideTetrahydroaldosterone-3-glucuronoside (see all 6)20605-81-6--
    Thyroxine glucuronidebeta-D 4-[4-(L-2-amino-2-carboxyethyl)-2,6-diiodophenoxy]-2,6-diiodophenyl glucopyranosiduronic acid (see all 7)21462-56-6--
    Triiodothyronine glucuronide(S)-4-(4-(2-amino-2-carboxyethyl)-2,6-diiodophenoxy)-2-iodophenyl-beta-D-Glucopyranosiduronic acid (see all 3)29919-72-0--
    Tyramine glucuronide4-(2-Aminoethyl)phenyl-beta-D-glucopyranosiduronic acid (see all 2)27972-85-6--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    Valproic acid glucuronide1-(2-propylpentanoate) beta-D-Glucopyranuronate (see all 18)60113-83-9--
    Vitamin D2 3-glucuronidevitamin D2 glucosiduronate (see all 4)----
    trans-3-Hydroxycotinine glucuronide3'-Hydroxycotnine-glucuronide (see all 3)132929-88-5--
    10/21 Novoseek chemical compound relationships for UGT1A7 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uridine diphosphate 80 4 16724991 (1), 12669388 (1), 16097053 (1)
    sn 38 79.4 4 12944498 (2), 18349289 (2)
    sn38 glucuronide 76.2 3 18418374 (1), 12181437 (1)
    glucuronide 73.4 2 9762354 (1), 11560872 (1)
    n-hydroxy phip 70.7 3 15310245 (1), 11375903 (1)
    irinotecan 66.5 15 18349289 (3), 15709193 (2), 12944498 (2), 19712005 (2) (see all 9)
    glucuronic acid 59.8 2 16159430 (1)
    flavopiridol 59.3 1 12944498 (1)
    uridine 58.8 3 17529886 (1), 16636344 (1), 17436274 (1)
    mycophenolic acid 53 7 17529886 (5), 18695635 (1)

    1 PharmGKB related drug/compound annotation for UGT1A7 gene
    Drug/compound PharmGKB Annotation
    valproic acidCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about UGT1A7 / UD17 

    Transcripts
    for UGT1A7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UGT1A7 gene: 
    NM_019077.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373426(uc010zmx.1 uc002vut.3) ENST00000485022

    miRNA
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    24/271 AceView cDNA sequences (see all 271):

    BE464186 BM829535 NM_021027 BE464379 AY435137 AY435136 NM_001072 AY435142 
    NM_019077 AY435138 NM_000463 NM_019075 NM_019076 CB163341 AU076863 BG165230 
    BI764371 NM_007120 AY435143 BC043491 AY435144 NM_205862 AY435141 AI767337 

    GeneLoc Exon Structure


    Expression
    for UGT1A7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT1A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See UGT1A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT1A7

    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Tissue specificity: Liver and gastric tissue

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    Orthologs
    for UGT1A7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A7 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1P1M7_CHICK6
    --
    (see all 5)    		 Uncharacterized protein
    (see all 5)    		 58(a)
    46(a)
    (see all 5)    		 possible ortholog
    possible ortholog
    (see all 5)    		 7(5795449-5817899)
    7(5844610-5845328)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    UGT1A66
    (see all 3)    		 --
    		 55(a)
    42(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 1(118894319-118901649)
    1(118848249-118849106)
    zebrafish
    (Danio rerio)    		 Actinopterygii ugt1ab6
    ugt1b46
    		 UDP glucuronosyltransferase 1 family a, b
    UDP glucuronosyltransferase 1 family, polypeptide ...
    		 50(a)
    46(a)
    		 many ↔ many
    many ↔ many
    		 9(10194767-10228512)
    11(31171792-31204741)


    ENSEMBL Gene Tree for UGT1A7 (if available)
    TreeFam Gene Tree for UGT1A7 (if available) 

    Paralogs
    for UGT1A7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT1A7 gene
    UGT1A81 2  UGT1A101 2  UGT1A91 2  UGT2A22  UGT3A12  UGT2B72  UGT2B112  UGT1A32  
    UGT1A12  UGT1A52  UGT3A22  UGT2B102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2B172  UGT2A32  UGT2B282  UGT1A42  
    18/30 SIMAP similar genes for UGT1A7 using alignment to 16 protein entries:     UD17_HUMAN (see all proteins) (see all similar genes):
    UGT1G    UGT1A8S    UGT1A9S    UGT1A10    UGT1J    UGT1A8
    UGT1A3S    UGT1H    UGT1A9    UGT1A6    UGT1A6S    UGT2B17
    BILIQTL1    UGT1A1    UGT1    UGT2B28    UGT2B11    UGT1A4S

    UGT1A7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for UGT1A7
    PGOHUM00000241145 PGOHUM00000241146


    Genomic Variants
    for UGT1A7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: UD17_HUMAN, Q9HAW7
    Polymorphism: There are four common allelic UGT1A7 variants which exhibit significant differences in catalytic activity
    towards 3-, 7-, and 9-hydroxy-benzo(a)pyrene. UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared to UGT1A7*1,
    whereas UGT1A7*2 and UGT1A7*4 have a 2.6- and 2.8-fold lower relative Vmax than UGT1A7*1, respectively, suggesting
    that these mutations confer slow glucuronidation phenotype


    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for UGT1A7
         10 CNVs: 90342 90341 61892 35795 50416 39282 37520 39281 63332 90340
    Human Gene Mutation Database (HGMD): UGT1A7

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    Disorders / Diseases
    for UGT1A7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UGT1A7 for disorders           About GeneDecksing

    OMIM gene information: 606432    OMIM disorders: --

    20/29 diseases for UGT1A7 (see all 29):    About MalaCards
    gilbert syndrome    neonatal jaundice    drug dependence    orolaryngeal cancer
    kernicterus    hearing loss    hepatitis c    hepatitis b
    liver cirrhosis    pancreatitis    hepatocellular carcinoma    pandas
    jaundice    pancreatic diseases    neutropenia    pancreatic cancer
    colorectal cancer    crohn's disease    hepatitis    liver disease

    1 disease from the University of Copenhagen DISEASES database for UGT1A7:
    Bilirubin metabolic disorder

    10/15 Novoseek disease relationships for UGT1A7 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gilberts syndrome 74.9 5 18349289 (3), 19303655 (1), 17850628 (1)
    pancreatic diseases 49.6 2 12806614 (1), 16199544 (1)
    hyperbilirubinemia 36.2 1 19303655 (1)
    hepatocellular carcinoma 35.3 16 11677206 (3), 18271934 (3), 15073122 (2), 15382168 (1) (see all 8)
    colorectal cancer 33.5 12 16620591 (4), 12010889 (1), 15709193 (1), 19364970 (1) (see all 6)
    chronic pancreatitis 32.3 4 16199544 (2), 12806614 (1), 17325733 (1)
    genetic susceptibility 15.1 3 16159430 (2), 16724991 (1)
    cancer 13 7 11677206 (2), 17406868 (2), 12010889 (1), 16620591 (1) (see all 5)
    hepatitis c 12.8 4 11343231 (1), 18054330 (1), 15073122 (1), 16086712 (1)
    pancreatic cancer 12.8 7 16199544 (4), 17072959 (2), 12806614 (1)

    Genetic Association Database (GAD): UGT1A7
    Human Genome Epidemiology (HuGE) Navigator: UGT1A7 (57 documents)

    Export disorders for UGT1A7 gene to outside databases

    Publications
    for UGT1A7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT1A7 gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with UGT1A7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)1, 2, 3, 9 Gong Q.H....Popescu N.C. (2001)
    2. Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer. (PubMed id 16030093)1, 4, 9 Butler L.M....Guillemette C. (2005)
    3. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. (PubMed id 16086712)1, 4, 9 Tseng C.S....Huang C.S. (2005)
    4. Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. (PubMed id 15682470)1, 4, 9 Huang M.J....Huang C.S. (2005)
    5. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. (PubMed id 11037804)1, 2, 9 Guillemette C.... Housman D.E. (2000)
    6. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. (PubMed id 16199544)1, 4, 9 Verlaan M....Witt H. (2005)
    7. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. (PubMed id 12010889)1, 4, 9 Strassburg C.P....Manns M.P. (2002)
    8. [Correlation of polymorphisms of UDP-glucuronosyltransferase 1A7 gene to genetic susceptibility of lung cancer] (PubMed id 16159430)1, 4, 9 Feng F.Y....Lin D.X. (2005)
    9. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection. (PubMed id 15073122)1, 4, 9 Wang Y....Omata M. (2004)
    10. UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. (PubMed id 12806614)1, 4, 9 Ockenga J....Strassburg C.P. (2003)

    External Searches for UGT1A7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
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    Genome Databases showing UGT1A7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54577 HGNC: 12539 AceView: UGT1A1 Ensembl:ENSG00000244122 euGenes: HUgn54577
    ECgene: UGT1A7 Kegg: 54577 H-InvDB: UGT1A7

    Other Databases showing UGT1A7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UGT1A7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT1A7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UGT1A7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UGT1A7 gene:
    Search GeneIP for patents involving UGT1A7

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