Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UGT1A7 Gene

Aliases for UGT1A7 Gene

  • UDP Glucuronosyltransferase 1 Family, Polypeptide A7 2 3
  • UDP-Glucuronosyltransferase 1-G 3 4
  • UDP-Glucuronosyltransferase 1A7 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 1-7 3 4
  • UGT1-07 3 4
  • UGT-1G 3 4
  • UGT1.7 3 4
  • UGT1G 3 4
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A7s 3
  • UDP Glycosyltransferase 1 Family, Polypeptide A6 2
  • UDP Glycosyltransferase 1 Family, Polypeptide A7 3
  • UDP-Glucuronosyltransferase 1-7 3
  • UGT1*7 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A7 Gene

Previous GeneCards Identifiers for UGT1A7 Gene

  • GC02U990247
  • GC02P234820
  • GC02P234883
  • GC02P234368
  • GC02P234372
  • GC02P234198
  • GC02P234209
  • GC02P234218
  • GC02P234255
  • GC02P234581
  • GC02P226390

Summaries for UGT1A7 Gene

Entrez Gene Summary for UGT1A7 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A7 Gene

UGT1A7 (UDP Glucuronosyltransferase 1 Family, Polypeptide A7) is a Protein Coding gene. Diseases associated with UGT1A7 include irinotecan toxicity and bilirubin metabolic disorder. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT1A7 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A7 Gene

Genomics for UGT1A7 Gene

Regulatory Elements for UGT1A7 Gene

Genomic Location for UGT1A7 Gene

Start:
233,681,938 bp from pter
End:
233,773,299 bp from pter
Size:
91,362 bases
Orientation:
Plus strand

Genomic View for UGT1A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT1A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A7 Gene

Proteins for UGT1A7 Gene

  • Protein details for UGT1A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAW7-UD17_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-7
    Protein Accession:
    Q9HAW7
    Secondary Accessions:
    • B8K293
    • O00473

    Protein attributes for UGT1A7 Gene

    Size:
    530 amino acids
    Molecular mass:
    59819 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity

    Alternative splice isoforms for UGT1A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A7 Gene

Proteomics data for UGT1A7 Gene at MOPED

Post-translational modifications for UGT1A7 Gene

  • Glycosylation at Asn71, Asn292, and Asn344
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT1A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UGT1A7 Gene

Gene Families for UGT1A7 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Graphical View of Domain Structure for InterPro Entry

Q9HAW7

UniProtKB/Swiss-Prot:

UD17_HUMAN :
  • Q9HAW7
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A7: view

Function for UGT1A7 Gene

Molecular function for UGT1A7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A7 Gene

Gene Ontology (GO) - Molecular Function for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
GO:0004857 enzyme inhibitor activity IGI 20610558
GO:0005080 protein kinase C binding IDA 18556656
GO:0008144 drug binding IDA 20610558
GO:0015020 NOT glucuronosyltransferase activity IGI 20610558
genes like me logo Genes that share ontologies with UGT1A7: view

Phenotypes for UGT1A7 Gene

GenomeRNAi human phenotypes for UGT1A7:
genes like me logo Genes that share phenotypes with UGT1A7: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT1A7 Gene

Localization for UGT1A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A7 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A7 Gene COMPARTMENTS Subcellular localization image for UGT1A7 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum NAS 20610558
GO:0005789 endoplasmic reticulum membrane NAS 20610558
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT1A7: view

Pathways for UGT1A7 Gene

genes like me logo Genes that share pathways with UGT1A7: view

Interacting Proteins for UGT1A7 Gene

Gene Ontology (GO) - Biological Process for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006631 fatty acid metabolic process IDA 20610558
GO:0007588 excretion IC 20056724
GO:0008152 metabolic process --
GO:0009804 coumarin metabolic process IC 19996319
genes like me logo Genes that share ontologies with UGT1A7: view

Compounds for UGT1A7 Gene

(84) HMDB Compounds for UGT1A7 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available

(21) Novoseek inferred chemical compound relationships for UGT1A7 Gene

Compound -log(P) Hits PubMed IDs
uridine diphosphate 80 3
sn 38 79.4 4
sn38 glucuronide 76.2 2
glucuronide 73.4 2
n-hydroxy phip 70.7 2

(1) PharmGKB related drug/compound annotations for UGT1A7 Gene

Drug/compound Annotation
valproic acid CA
genes like me logo Genes that share compounds with UGT1A7: view

Transcripts for UGT1A7 Gene

mRNA/cDNA for UGT1A7 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A7 Gene

No ASD Table

Relevant External Links for UGT1A7 Gene

GeneLoc Exon Structure for
UGT1A7
ECgene alternative splicing isoforms for
UGT1A7

Expression for UGT1A7 Gene

mRNA expression in normal human tissues for UGT1A7 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A7 Gene

This gene is overexpressed in Esophagus - Mucosa (40.8) and Minor Salivary Gland (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT1A7 Gene

mRNA Expression by UniProt/SwissProt for UGT1A7 Gene

Q9HAW7-UD17_HUMAN
Tissue specificity: Liver and gastric tissue. Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212).
genes like me logo Genes that share expressions with UGT1A7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UGT1A7 Gene

Orthologs for UGT1A7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UGT1A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT1A7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC152010 36
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ugt1a10 36
  • 79 (a)
ManyToMany
Ugt1a7c 36
  • 78 (a)
ManyToMany
Ugt1a8 36
  • 78 (a)
ManyToMany
Ugt1a9 35
  • 81.44 (n)
  • 80.98 (a)
Ugt1a9 36
  • 80 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ugt1a8 35
  • 81.96 (n)
  • 79.8 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 59 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ugt1a7 36
  • 49 (a)
ManyToMany
ugt1b1 36
  • 46 (a)
ManyToMany
ugt1b2 36
  • 45 (a)
ManyToMany
ugt1b3 36
  • 45 (a)
ManyToMany
ugt1b4 36
  • 46 (a)
ManyToMany
ugt1b5 36
  • 45 (a)
ManyToMany
Species with no ortholog for UGT1A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UGT1A7 Gene

ENSEMBL:
Gene Tree for UGT1A7 (if available)
TreeFam:
Gene Tree for UGT1A7 (if available)

Paralogs for UGT1A7 Gene

Pseudogenes.org Pseudogenes for UGT1A7 Gene

genes like me logo Genes that share paralogs with UGT1A7: view

Variants for UGT1A7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A7 Gene

Q9HAW7-UD17_HUMAN
There are four common allelic UGT1A7 variants which exhibit significant differences in catalytic activity towards 3-, 7-, and 9-hydroxy-benzo(a)pyrene. UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared to UGT1A7*1, whereas UGT1A7*2 and UGT1A7*4 have a 2.6- and 2.8-fold lower relative Vmax than UGT1A7*1, respectively, suggesting that these mutations confer slow glucuronidation phenotype

Sequence variations from dbSNP and Humsavar for UGT1A7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_015556 -
VAR_015557 -
VAR_015558 -
VAR_052462 -

Structural Variations from Database of Genomic Variants (DGV) for UGT1A7 Gene

Variant ID Type Subtype PubMed ID
esv2721666 CNV Deletion 23290073
nsv876016 CNV Gain 21882294
nsv876017 CNV Loss 21882294
esv2721667 CNV Deletion 23290073
nsv3215 CNV Loss 18451855
esv2721668 CNV Deletion 23290073
esv2661542 CNV Deletion 23128226
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061
esv8142 CNV Loss 19470904
esv2721669 CNV Deletion 23290073
nsv876018 CNV Gain 21882294

Relevant External Links for UGT1A7 Gene

HapMap Linkage Disequilibrium report
UGT1A7
Human Gene Mutation Database (HGMD)
UGT1A7

Disorders for UGT1A7 Gene

(2) University of Copenhagen DISEASES for UGT1A7 Gene

(15) Novoseek inferred disease relationships for UGT1A7 Gene

Disease -log(P) Hits PubMed IDs
gilberts syndrome 74.9 5
pancreatic diseases 49.6 2
hyperbilirubinemia 36.2 1
hepatocellular carcinoma 35.3 13
colorectal cancer 33.5 9

Relevant External Links for UGT1A7

Genetic Association Database (GAD)
UGT1A7
Human Genome Epidemiology (HuGE) Navigator
UGT1A7
genes like me logo Genes that share disorders with UGT1A7: view

No data available for UniProtKB/Swiss-Prot for UGT1A7 Gene

Publications for UGT1A7 Gene

  1. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PMID: 11434514) Gong Q.H. … Popescu N.C. (Pharmacogenetics 2001) 2 3 4 23
  2. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Menard V. … Guillemette C. (Hum. Mutat. 2009) 3 4 23 48
  3. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. (PMID: 19303655) Lankisch T.O. … Strassburg C.P. (J. Hepatol. 2009) 3 23 48
  4. Combined UGT1A1 and UGT1A7 variant alleles are associated with increased risk of Gilbert's syndrome in Taiwanese adults. (PMID: 17850628) Teng H.C. … Huang C.S. (Clin. Genet. 2007) 3 23 48
  5. DNA-repair and carcinogen-metabolising enzymes genetic polymorphisms as an independent risk factor for hepatocellular carcinoma in Caucasian liver-transplanted patients. (PMID: 17870518) Borentain P. … GAcrolami R. (Eur. J. Cancer 2007) 3 23 48

Products for UGT1A7 Gene

  • antibodies-online peptides for UGT1A7
  • antibodies-online antibodies for UGT1A7
  • antibodies-online kits for UGT1A7

Sources for UGT1A7 Gene

Back to Top

Content