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Aliases for UGT1A7 Gene

Aliases for UGT1A7 Gene

  • UDP Glucuronosyltransferase Family 1 Member A7 2 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A7 2 3
  • UDP-Glucuronosyltransferase 1-G 3 4
  • UDP-Glucuronosyltransferase 1A7 3 4
  • EC 2.4.1.17 4 61
  • UDPGT 1-7 3 4
  • UGT1-07 3 4
  • UGT-1G 3 4
  • UGT1.7 3 4
  • UGT1G 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A7 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A7s 3
  • UDP-Glucuronosyltransferase 1-7 3
  • UGT1*7 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A7 Gene

Previous GeneCards Identifiers for UGT1A7 Gene

  • GC02U990247
  • GC02P234820
  • GC02P234883
  • GC02P234368
  • GC02P234372
  • GC02P234198
  • GC02P234209
  • GC02P234218
  • GC02P234255
  • GC02P234581
  • GC02P226390

Summaries for UGT1A7 Gene

Entrez Gene Summary for UGT1A7 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A7 Gene

UGT1A7 (UDP Glucuronosyltransferase Family 1 Member A7) is a Protein Coding gene. Diseases associated with UGT1A7 include Gilbert Syndrome and Bilirubin Metabolic Disorder. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A8.

UniProtKB/Swiss-Prot for UGT1A7 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A7 Gene

Genomics for UGT1A7 Gene

Regulatory Elements for UGT1A7 Gene

Enhancers for UGT1A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F233688 0.2 ENCODE 0.4 +9.1 9064 4.1 JUN CEBPB ZNF140 DPF2 EP300 ATF2 YY1 JUND GATA3 ATF3 USP40 UGT1A4 SCARNA6 UGT1A6 MROH2A UGT1A7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UGT1A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT1A7 Gene

Chromosome:
2
Start:
233,681,938 bp from pter
End:
233,773,299 bp from pter
Size:
91,362 bases
Orientation:
Plus strand

Genomic View for UGT1A7 Gene

Genes around UGT1A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A7 Gene

Proteins for UGT1A7 Gene

  • Protein details for UGT1A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAW7-UD17_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-7
    Protein Accession:
    Q9HAW7
    Secondary Accessions:
    • B8K293
    • O00473

    Protein attributes for UGT1A7 Gene

    Size:
    530 amino acids
    Molecular mass:
    59819 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A7 Gene

Post-translational modifications for UGT1A7 Gene

  • Glycosylation at Asn 71, Asn 292, and Asn 344
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT1A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UGT1A7 (UGT1A7)
  • Santa Cruz Biotechnology (SCBT) Antibodies for UGT1A7

Domains & Families for UGT1A7 Gene

Gene Families for UGT1A7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAW7

UniProtKB/Swiss-Prot:

UD17_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A7: view

Function for UGT1A7 Gene

Molecular function for UGT1A7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A7 Gene

Gene Ontology (GO) - Molecular Function for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
GO:0004857 enzyme inhibitor activity IDA 19996319
GO:0005080 protein kinase C binding IDA 18556656
GO:0015020 glucuronosyltransferase activity IDA 17179145
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UGT1A7: view
genes like me logo Genes that share phenotypes with UGT1A7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A7 Gene

Localization for UGT1A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A7 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A7 Gene COMPARTMENTS Subcellular localization image for UGT1A7 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 17179145
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with UGT1A7: view

Pathways & Interactions for UGT1A7 Gene

genes like me logo Genes that share pathways with UGT1A7: view

Gene Ontology (GO) - Biological Process for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007588 excretion IC 20056724
GO:0008152 metabolic process IEA --
GO:0009804 coumarin metabolic process IC 19996319
GO:0009813 flavonoid biosynthetic process IBA --
GO:0017144 drug metabolic process IC 19996319
genes like me logo Genes that share ontologies with UGT1A7: view

No data available for SIGNOR curated interactions for UGT1A7 Gene

Drugs & Compounds for UGT1A7 Gene

(34) Drugs for UGT1A7 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolic acid Approved Pharma Enzyme, substrate 939
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 939
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1080
Allopurinol Approved Pharma 137
Atazanavir Approved, Investigational Pharma HIV protease inhibitor,highly potent 0

(91) Additional Compounds for UGT1A7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SN38 glucuronide
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
genes like me logo Genes that share compounds with UGT1A7: view

Transcripts for UGT1A7 Gene

mRNA/cDNA for UGT1A7 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A7 Gene

No ASD Table

Relevant External Links for UGT1A7 Gene

GeneLoc Exon Structure for
UGT1A7
ECgene alternative splicing isoforms for
UGT1A7

Expression for UGT1A7 Gene

mRNA expression in normal human tissues for UGT1A7 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A7 Gene

This gene is overexpressed in Esophagus - Mucosa (x40.8) and Minor Salivary Gland (x5.5).

Protein differential expression in normal tissues from HIPED for UGT1A7 Gene

This gene is overexpressed in Kidney (42.3), Gallbladder (18.6), and Liver (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGT1A7 Gene



Protein tissue co-expression partners for UGT1A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT1A7 Gene:

UGT1A7

mRNA Expression by UniProt/SwissProt for UGT1A7 Gene:

Q9HAW7-UD17_HUMAN
Tissue specificity: Liver and gastric tissue. Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212).
genes like me logo Genes that share expression patterns with UGT1A7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UGT1A7 Gene

Orthologs for UGT1A7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UGT1A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT1A7 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugt1a8 34
  • 81.96 (n)
mouse
(Mus musculus)
Mammalia Ugt1a9 34 35
  • 81.44 (n)
Ugt1a10 35
  • 79 (a)
ManyToMany
Ugt1a7c 35
  • 78 (a)
ManyToMany
Ugt1a8 35
  • 78 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 65 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MGC152010 35
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 59 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ugt1a7 35
  • 49 (a)
ManyToMany
ugt1b1 35
  • 46 (a)
ManyToMany
ugt1b4 35
  • 46 (a)
ManyToMany
ugt1b2 35
  • 45 (a)
ManyToMany
ugt1b3 35
  • 45 (a)
ManyToMany
ugt1b5 35
  • 45 (a)
ManyToMany
Species where no ortholog for UGT1A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UGT1A7 Gene

ENSEMBL:
Gene Tree for UGT1A7 (if available)
TreeFam:
Gene Tree for UGT1A7 (if available)

Paralogs for UGT1A7 Gene

Pseudogenes.org Pseudogenes for UGT1A7 Gene

genes like me logo Genes that share paralogs with UGT1A7: view

Variants for UGT1A7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A7 Gene

UD17_HUMAN-Q9HAW7
There are four common allelic UGT1A7 variants which exhibit significant differences in catalytic activity towards 3-, 7-, and 9-hydroxy-benzo(a)pyrene. UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared to UGT1A7*1, whereas UGT1A7*2 and UGT1A7*4 have a 2.6- and 2.8-fold lower relative Vmax than UGT1A7*1, respectively, suggesting that these mutations confer slow glucuronidation phenotype.

Sequence variations from dbSNP and Humsavar for UGT1A7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2011425 drug-response 233,718,962(+) AGGCC(G/T)TGCGG intron-variant, reference, missense
rs887829 drug-response 233,759,924(-) TTCCA(A/G)AAATT intron-variant, upstream-variant-2KB
rs111033539 Pathogenic 233,767,160(+) TCCCT(C/T)AGACA reference, stop-gained
rs111033541 Pathogenic 233,760,331(+) GGGCC(G/T)GCTGC intron-variant, reference, missense
rs281865418 Pathogenic 233,761,127(+) AACTG(A/C/G)CTTCA intron-variant, reference, missense, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for UGT1A7 Gene

Variant ID Type Subtype PubMed ID
dgv769e199 CNV deletion 23128226
esv2422005 CNV deletion 20811451
esv25622 CNV loss 19812545
esv2661542 CNV deletion 23128226
esv2721666 CNV deletion 23290073
esv2721667 CNV deletion 23290073
esv2721668 CNV deletion 23290073
esv2721669 CNV deletion 23290073
esv2760613 CNV loss 21179565
esv2760615 CNV loss 21179565
esv3561178 CNV deletion 23714750
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv1126580 CNV deletion 24896259
nsv1138902 CNV deletion 24896259
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584705 CNV loss 21841781
nsv961573 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv963781 CNV duplication 23825009
nsv963782 CNV duplication 23825009
nsv979185 CNV duplication 23825009
nsv979186 CNV duplication 23825009
nsv979187 CNV duplication 23825009

Variation tolerance for UGT1A7 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT1A7 Gene

Human Gene Mutation Database (HGMD)
UGT1A7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT1A7

Disorders for UGT1A7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UGT1A7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gilbert syndrome
  • constitutional hyperbilirubinemia
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
irinotecan toxicity
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT1A7

Genetic Association Database (GAD)
UGT1A7
Human Genome Epidemiology (HuGE) Navigator
UGT1A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT1A7
genes like me logo Genes that share disorders with UGT1A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A7 Gene

Publications for UGT1A7 Gene

  1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Menard V. … Guillemette C. (Hum. Mutat. 2009) 3 4 22 46 64
  2. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PMID: 11434514) Gong Q.H. … Popescu N.C. (Pharmacogenetics 2001) 2 3 4 22 64
  3. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. (PMID: 19364970) Cecchin E. … Toffoli G. (J. Clin. Oncol. 2009) 3 22 46 64
  4. Uridine diphosphoglucuronosyltransferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers. (PMID: 19430315) Wang Y. … Zheng Y. (J. Occup. Environ. Med. 2009) 3 22 46 64
  5. [Association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer]. (PMID: 20193274) Liu J. … Song D.K. (Zhonghua Yi Xue Za Zhi 2009) 3 22 46 64

Products for UGT1A7 Gene

Sources for UGT1A7 Gene

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