Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UGT1A6 Gene

protein-coding   GIFtS: 58
GCID: GC02P234600

UDP Glucuronosyltransferase 1 Family, Polypeptide A6

(Previous names: UDP glycosyltransferase 1 family, polypeptide A6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A61 2     UDP-Glucuronosyltransferase 1-F2 3
UDP Glycosyltransferase 1 Family, Polypeptide A61 2     UDP-Glucuronosyltransferase 1A62 3
Phenol-Metabolizing UDP-Glucuronosyltransferase2 3     UDPGT 1-62 3
GNT12 3     EC 2.4.1.173 8
UGT-1F2 3     HLUGP2
UGT12 3     HLUGP12
UGT1*62 3     UDPGT2
UGT1-062 3     UGT1A6S2
UGT1.62 3     UDP-Glucuronosyltransferase 1 Family Polypeptide A6s2
UGT1F2 3     UDP-Glucuronosyltransferase 1-62

External Ids:    HGNC: 125381   Entrez Gene: 545782   Ensembl: ENSG000001671657   OMIM: 6064315   UniProtKB: P192243   

Export aliases for UGT1A6 gene to outside databases

Previous GC identifers: GC02U990248 GC02P234819 GC02P234882 GC02P234367 GC02P234382 GC02P234197 GC02P234208 GC02P234217 GC02P234265 GC02P226400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UGT1A6 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on
phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript
variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A6 Gene:
UGT1A6 (UDP glucuronosyltransferase 1 family, polypeptide A6) is a protein-coding gene. Diseases associated with UGT1A6 include crigler najjar syndrome, type 2, and drug-induced hepatitis. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds. This isoform has specificity for phenols

Gene Wiki entry for UGT1A6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the UGT1A6 gene promoter:
         p53   AP-1   ATF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UGT1A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT1A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234600:  view genomic region     (about GC identifiers)

Start:
234,600,253 bp from pter      End:
234,681,951 bp from pter
Size:
81,699 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-6 precursor  
Size: 532 amino acids; 60751 Da
Sequence caution: Sequence=BM924331; Type=Erroneous termination; Positions=420; Note=Translated as Glu;
Sequence=BM924331; Type=Frameshift; Positions=451, 463; Sequence=BM924331; Type=Miscellaneous discrepancy;
Note=Probable cloning artifact;
Secondary accessions: A6NKK6 Q96TE7
Alternative splicing: 2 isoforms:  P19224-1   P19224-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UGT1A6: NX_P19224

Explore proteomics data for UGT1A6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn294, Asn346
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGT1A6 (P19224) (see all 21)
     FWVEFVM  QYHSLDV  DVIGFLL  GSHWLSM 


    See UGT1A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001063.2  NP_995584.1  

    ENSEMBL proteins: 
     ENSP00000362523   ENSP00000389637   ENSP00000401541   ENSP00000303174   ENSP00000419780  
     ENSP00000386107  
    Reactome Protein details: P19224

    UGT1A6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UGT1A6
    OriGene Protein Over-expression Lysate for UGT1A6
    OriGene MassSpec for UGT1A6
    OriGene Custom Protein Services for UGT1A6
    GenScript Custom Purified and Recombinant Proteins Services for UGT1A6
    Novus Biologicals UGT1A6 Proteins
    Novus Biologicals UGT1A6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UGT1A6

    UGT1A6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UGT1A6
    OriGene Custom Antibody Services for UGT1A6
    Novus Biologicals UGT1A6 Antibodies
    Abcam antibodies for UGT1A6
    Cloud-Clone Corp. Antibodies for UGT1A6
    ThermoFisher Antibodies for UGT1A6
    LSBio Antibodies in human, mouse, rat for UGT1A6

    UGT1A6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UGT1A6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UGT1A6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UGT1A6
    Cloud-Clone Corp. CLIAs for UGT1A6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P19224

    ProtoNet protein and cluster: P19224

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD16_HUMAN, P19224
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT1A6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD16_HUMAN, P19224
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds. This isoform has specificity for phenols
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972NOT retinoic acid binding IDA--
    GO:0015020glucuronosyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0019899enzyme binding IDA--
    GO:0030246carbohydrate binding ----
         
    UGT1A6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT1A6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGT1A6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGT1A6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGT1A6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UGT1A6 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate UGT1A6:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UGT1A6
    Predesigned siRNA for gene silencing in human, mouse, rat UGT1A6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UGT1A6

    Clone
    Products:
         
    OriGene clones in human, mouse for UGT1A6 (see all 12)
    OriGene ORF clones in mouse, rat for UGT1A6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UGT1A6 (NM_001072)
    Sino Biological Human cDNA Clone for UGT1A6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT1A6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UGT1A6
    Browse ESI BIO Cell Lines and PureStem Progenitors for UGT1A6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UD16_HUMAN, P19224: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    nucleus2
    plasma membrane2
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    UGT1A6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UGT1A6 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Glucuronidation0.00
    Phase II conjugation0.56
    Acetaminophen metabolism0.00
    metapathway biotransformation0.42
    Phenytoin Pathway, Pharmacokinetics0.00
    2Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Metabolism of xenobiotics by cytochrome P4500.71
    Benzo a pyrene metabolism0.00
    Drug metabolism - cytochrome P4500.69
    4Metabolism of porphyrins
    Metabolism of porphyrins0.56
    Heme degradation0.00
    Porphyrin and chlorophyll metabolism0.56
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for UGT1A6
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Benzo[a]pyrene metabolism
    Acetaminophen metabolism

    Selected BioSystems Pathways for UGT1A6 (see all 6)
        Glucuronidation
    Irinotecan Pathway
    Oxidative Stress
    Estrogen metabolism
    AhR pathway


    1 Reactome Pathway for UGT1A6
        Glucuronidation

    4 PharmGKB Pathways for UGT1A6
        Acetaminophen Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacodynamics
    Phenytoin Pathway, Pharmacokinetics
    Valproic Acid Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for UGT1A6) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT1A6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UGT1A6
    Interactions:

        GeneGlobe Interaction Network for UGT1A6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT1A6 (ENSP000003031744) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH6ENSP000003783594STRING: ENSP00000378359
    ADH7ENSP000002096654STRING: ENSP00000209665
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0030259lipid glycosylation ----
    GO:0044281small molecule metabolic process TAS--

    UGT1A6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT1A6 (UD16)

    Selected HMDB Compounds for UGT1A6 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetaminophen glucuronide4-acetamidophenyl b-D-glucopyranosiduronic acid (see all 8)16110-10-411903872 11714888
    Ethyl glucuronide 17685-04-016139098
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    Valproic acid glucuronide1-(2-propylpentanoate) beta-D-Glucopyranuronate (see all 18)60113-83-912732356
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----

    Selected Novoseek inferred chemical compound relationships for UGT1A6 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-methylumbelliferone 88.9 11 9058595 (1), 10220484 (1), 16545899 (1), 17027947 (1) (see all 7)
    udp glucuronic acid 86.1 2 9058595 (1), 9107538 (1)
    1-naphthol 83.9 9 8161205 (2), 11317477 (2), 19487247 (1), 11437353 (1) (see all 7)
    uridine diphosphate 81.8 6 16802850 (1), 19437564 (1), 18161889 (1), 16797247 (1) (see all 5)
    glucuronide 74.2 4 9762354 (1), 17359941 (1), 11560872 (1), 11408353 (1)
    beta-naphthoflavone 72.5 7 16545899 (3), 10901286 (1), 11437649 (1), 8738480 (1)
    p-nitrophenol 71.3 5 12695347 (1), 10471066 (1), 12386132 (1), 9107538 (1) (see all 5)
    n-hydroxy phip 68.6 2 11375903 (1)
    4-hydroxycoumarin 65.4 1 10471066 (1)
    3-methylcholanthrene 62.8 6 8689937 (1), 11274859 (1), 19525444 (1), 11437649 (1)

    1 PharmGKB related drug/compound annotation for UGT1A6 gene    About this table
    Drug/compound PharmGKB Annotation
    valproic acidCA  



    UGT1A6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UGT1A6 gene (2 alternative transcripts): 
    NM_001072.3  NM_205862.1  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373424 ENST00000441351 ENST00000480628 ENST00000446481 ENST00000305139(uc002vuu.3 uc002vuv.4)
    ENST00000484784 ENST00000478062 ENST00000406651
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UGT1A6 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate UGT1A6:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UGT1A6
    Predesigned siRNA for gene silencing in human, mouse, rat UGT1A6
    Clone
    Products:
         
    OriGene clones in human, mouse for UGT1A6 (see all 12)
    OriGene ORF clones in mouse, rat for UGT1A6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UGT1A6 (NM_001072)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT1A6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UGT1A6
    OriGene qSTAR qPCR primer pairs in human, mouse for UGT1A6
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat UGT1A6
      QuantiTect SYBR Green Assays in human, mouse, rat UGT1A6
      QuantiFast Probe-based Assays in human, mouse, rat UGT1A6

    Selected AceView cDNA sequences (see all 271):

    NM_019078 AK025403 NM_001072 NM_019093 BC053576 AI795931 AY435136 BG165230 
    BC043491 CB157019 AY435140 BE464379 AV660038 AI767337 BE463503 BM829535 
    AI478649 AI479279 AI701383 AY435137 AV646429 CB162031 AW297730 NM_021027 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A6 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:                    -     -     -     -     -     -     -     -     -     -     -                       -                     
    SP2:                                                  -     -     -     -     -     -                       -                     
    SP3:        -     -     -     -     -     -     -     -     -     -     -     -     -                       -                     
    SP4:                                                        -     -     -     -     -                       -                     
    SP5:                                                              -     -     -     -                       -                     


    ECgene alternative splicing isoforms for UGT1A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UGT1A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A6 Expression
    About this image


    UGT1A6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebellum
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    UGT1A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT1A6 Protein Expression

    UniProtKB/Swiss-Prot: UD16_HUMAN, P19224
    Tissue specificity: Expressed in skin, kidney and liver

        Custom PCR Arrays for UGT1A6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UGT1A6
    OriGene qSTAR qPCR primer pairs in human, mouse for UGT1A6
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat UGT1A6
    QuantiTect SYBR Green Assays in human, mouse, rat UGT1A6
    QuantiFast Probe-based Assays in human, mouse, rat UGT1A6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A6 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a6a1 , 5 UDP glucuronosyltransferase 1 family, polypeptide A6A1, 5 81.48(n)1
    79.66(a)1
      1 (44.52 cM)5
    942841  NM_145079.31  NP_659545.21 
     881348095 
    lizard
    (Anolis carolinensis)
    Reptilia UGT1A66
    UDP glucuronosyltransferase 1 family, polypeptide ...
    56(a)
    1 ↔ 1
    1(118848249-118849106)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1a76
    ugt1b26
    (see all 6)
    UDP glucuronosyltransferase 1 family, polypeptide ...
    UDP glucuronosyltransferase 1 family, polypeptide ...
    (see all 6)
    50(a)
    47(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    9(10194767-10228491) ENSDARG00000006220
    11(31190339-31204509) ENSDARG00000097231


    ENSEMBL Gene Tree for UGT1A6 (if available)
    TreeFam Gene Tree for UGT1A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UGT1A6 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  
    UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    Selected SIMAP similar genes for UGT1A6 using alignment to 6 protein entries:     UD16_HUMAN (see all proteins) (see all similar genes):
    UGT1A6S    UGT1A3S    UGT1A9S    UGT1A8S    UGT1A10    UGT1A1
    BILIQTL1    UGT1A4S    UGT1A8    UGT2A3    UGT1A9    UGT1A4
    UGT2B7    UGT1A5    UGT1A7    UGT2B4    UGT2B15    UGT2B17

    UGT1A6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    UD16_HUMAN, P19224: Polymorphisms in the UGT1A6 gene define four common haplotypes: UGT1A6*1, UGT1A6*2, UGT1A6*3 and
    UGT1A6*4. Liver tissue samples that were homozygous for UGT1A6*2 exhibited a high rate of glucuronidation
    relative to tissues with other genotypes. Biochemical kinetic studies indicate that the UGT1A6*2 allozyme,
    expressed homozygously, had almost two-fold greater activity toward p-nitrophenol than UGT1A6*1 and when
    expressed heterozygously (UGT1A6*1/*2) it is associated with low enzyme activity. Common genetic variation in
    UGT1A6 confers functionally significant differences in biochemical phenotype. This genetic variation might impact
    clinical efficacy or toxicity of drugs metabolized by UGT1A6


    5 SNPs for UGT1A6    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10427091,2,4
    ----see VAR_0266292 mis40--------
    rs67598921,2,4
    ----see VAR_0246852 mis40--------
    rs20709591,2,4
    ----see VAR_0147842 mis40--------
    rs10427081,2,4
    ----see VAR_0266282 mis40--------
    rs11058791,2,4
    ----see VAR_0155592 mis40--------

    HapMap Linkage Disequilibrium report for UGT1A6 (234600253 - 234681951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGT1A6 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2661542CNV Deletion23128226
    esv2721667CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721669CNV Deletion23290073
    esv2721668CNV Deletion23290073
    nsv514125CNV Loss21397061
    nsv433211CNV Loss18776910
    nsv498958CNV Loss21111241
    nsv876017CNV Loss21882294

    Human Gene Mutation Database (HGMD): UGT1A6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT1A6
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606431    OMIM disorders: --

    Selected diseases for UGT1A6 (see all 35):    
    About MalaCards
    crigler najjar syndrome, type 2    drug-induced hepatitis    crigler-najjar syndrome    bilirubin metabolic disorder
    gilbert syndrome    kernicterus    neonatal jaundice    sickle cell anemia
    peptic ulcer    cholelithiasis    colon adenocarcinoma    autoimmune hepatitis
    pharyngitis    diarrhea    familial adenomatous polyposis    neutropenia
    duodenitis    colorectal cancer    adenocarcinoma    adenoma

    7 diseases from the University of Copenhagen DISEASES database for UGT1A6:
    Bilirubin metabolic disorder     Neonatal jaundice     Neutropenia     Diarrhea
    Colorectal cancer     Kernicterus     Cholelithiasis

    UGT1A6 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for UGT1A6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 48.6 4 9762354 (1), 10220484 (1), 9466822 (1), 19831498 (1)
    colon adenocarcinoma 24.2 1 15826610 (1)
    adenoma 18.5 9 17085674 (5), 19437564 (3), 16797247 (1)
    lung carcinoma 9.04 1 9466822 (1)
    tumors 2.04 3 15709193 (1), 17085674 (1), 19448967 (1)
    colorectal cancer 0 4 16797247 (4)

    Genetic Association Database (GAD): UGT1A6
    Human Genome Epidemiology (HuGE) Navigator: UGT1A6 (51 documents)

    Export disorders for UGT1A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UGT1A6 gene, integrated from 10 sources (see all 217):
    (articles sorted by number of sources associating them with UGT1A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. (PubMed id 15284531)1, 2, 4, 9 Nagar S.... Blanchard R.L. (Pharmacogenetics 2004)
    2. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)1, 2, 4, 9 Menard V.... Guillemette C. (Hum. Mutat. 2009)
    3. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. (PubMed id 1339448)1, 2, 3 Ritter J.K....Owens I.S. (J. Biol. Chem. 1992)
    4. Genetic variants of UGT1A6 influence risk of colorectal adenoma recurrence. (PubMed id 17085674)1, 4, 9 Hubner R.A....Houlston R.S. (Clin. Cancer Res. 2006)
    5. Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 are not associated with NSAIDs-related peptic ulcer haemorrhage. (PubMed id 19799547)1, 4, 9 van Oijen M.G....Drenth J.P. (Drug Metab Lett 2009)
    6. Effect of genetic polymorphisms in UDP-glucuronosyltransferase 1A6 (UGT1A6) on acetylsalicylic acid metabolism in healthy female volunteers. (PubMed id 19262071)1, 4, 9 van Oijen M.G....Jansen J.B. (Pharmacology 2009)
    7. Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. (PubMed id 16797247)1, 4, 9 Samowitz W.S....Slattery M.L. (Clin. Gastroenterol. Hepatol. 2006)
    8. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP- glucuronosyltransferase: pharmacological implications. (PubMed id 9429234)1, 2, 9 Ciotti M.... Owens I.S. (Pharmacogenetics 1997)
    9. Characterizing the effects of common UDP glucuronosyltransferase (UGT) 1A6 and UGT1A1 polymorphisms on cis- and trans-resveratrol glucuronidation. (PubMed id 19406951)1, 4, 9 Iwuchukwu O.F....Nagar S. (Drug Metab. Dispos. 2009)
    10. No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. (PubMed id 19437564)1, 4, 9 Thompson C.L....Li L. (World J. Gastroenterol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54578 HGNC: 12538 AceView: UGT1A1 Ensembl:ENSG00000167165 euGenes: HUgn54578
    ECgene: UGT1A6 Kegg: 54578 H-InvDB: UGT1A6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UGT1A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UGT1A6 gene:
    Search GeneIP for patents involving UGT1A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UGT1A6   OriGene RNAi products in human, mouse, rat for UGT1A6  
     OriGene qPCR primer pairs and template standards for UGT1A6   OriGene Protein Over-expression Lysate for UGT1A6  
     OriGene MassSpec something-or-other for UGT1A6   OriGene clones in human, mouse for UGT1A6  
     OriGene qSTAR qPCR primer pairs in human, mouse for UGT1A6   OriGene Purified Protein for UGT1A6  
     OriGene ORF clones in mouse, rat for UGT1A6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UGT1A6   OriGene Custom Protein Services for UGT1A6  

     
     
     Block miRNA regulation of human, mouse, rat UGT1A6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UGT1A6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT1A6 Predesigned siRNA for gene silencing in human, mouse, rat UGT1A6
     QuantiFast Probe-based Assays in human, mouse, rat UGT1A6 QuantiTect SYBR Green Assays in human, mouse, rat UGT1A6
     Custom PCR Arrays for UGT1A6 Search Chromatin IP Primers for UGT1A6
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UGT1A6  GeneGlobe Interaction Network for UGT1A6
     Regulatory tfbs in UGT1A6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UGT1A6 GenScript cDNA clones with any tag delivered in your preferred vector for UGT1A6
     GenScript Custom Assay Services for UGT1A6 GenScript Custom overexpressing Cell Line Services for UGT1A6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UGT1A6 (UD16)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for UGT1A6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UGT1A6 antibodies
     UGT1A6 proteins
     UGT1A6 lysates
     Antibodies for UGT1A6
     See all of Abcam's Antibodies, Kits and Proteins for UGT1A6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UGT1A6
     Antibodies for UGT1A6
     ELISAs for UGT1A6
     CLIAs for UGT1A6



     Browse ESI BIO Cell Lines and PureStem Progenitors for UGT1A6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for UGT1A6
     Browse SwitchGear Promoter luciferase reporter plasmids for UGT1A6
     ThermoFisher Antibodies for UGT1A6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT1A6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGT1A6
     LSBio Antibodies in human, mouse, rat for UGT1A6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UGT1A6 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4