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UGT1A6 Gene

protein-coding   GIFtS: 51

GC02P234600
UDP glucuronosyltransferase 1 family, polypeptide A6
(Previous names: UDP glycosyltransferase 1 family, polypeptide A6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for UGT1A6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
UDP glucuronosyltransferase 1 family, polypeptide A61 2     UGT1-062 3
GNT11 2 3     UDPGT2
UGT1F1 2 3     UGT1A6S2
HLUGP1 2     UDP-glucuronosyltransferase 1 family polypeptide A6s2
UDP glycosyltransferase 1 family, polypeptide A61 2     UDP-glucuronosyltransferase 1-62
Phenol-metabolizing UDP-glucuronosyltransferase2 3     HLUGP12
UGT1.62 3     MGC298602
UGT12 3     EC 2.4.1.173
UDP-glucuronosyltransferase 1A62 3     UDPGT 1-63
UGT1*62 3     UDP-glucuronosyltransferase 1-F3
UGT-1F2 3     

External Ids:    HGNC: 125381   Entrez Gene: 545782   Ensembl: ENSG000001671657   UniProtKB: P192243   

Search outside databases for aliases for UGT1A6 gene

Previous GC identifers: GC02U990248 GC02P234819 GC02P234882 GC02P234367 GC02P234382 GC02P234197 GC02P234208 GC02P234217 GC02P234265

Summaries
for UGT1A6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  User Feedback		 Entrez Gene summary for UGT1A6:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen
unique alternate first exons followed by four common exons. Four of the alternate first exons are considered
pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine
proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is
regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative
splicing in the unique 5' end of this gene results in two transcript variants. (provided by RefSeq)

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds. This isoform has specificity for phenols

Gene Wiki entry for UGT1A6

Genomic Views
for UGT1A6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the UGT1A6 gene upstream (promoter) region "":
GR-alpha   AP-1   HNF-4alpha2   c-Fos   c-Jun   GR-beta   PPAR-gamma1   PPAR-gamma2   p53   COUP-TF1   

Epigenetics:
"" Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for UGT1A6 ""

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A6 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234600:  view genomic region     (about GC identifiers)

Start:
 234,600,253 bp from pter
End:
 234,681,951 bp from pter
Size:
 81,699 bases
Orientation:
 plus strand

Proteins
for UGT1A6 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: UD16_HUMAN, P19224 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-6 precursor  
Size: 532 amino acids; 60751 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q96TE7
Alternative splicing: 1 isoform:  P19224-1   (A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues)

REFSEQ proteins (2 alternative transcripts): 
NP_001063.2  NP_995584.1  


ENSEMBL proteins: 
ENSP00000303174 ENSP00000362523 ENSP00000401541 ENSP00000386107 ENSP00000389637 ENSP00000419780 
ENSP00000353593 


Human Recombinant Proteins 
""Browse Purified and Recombinant Proteins at Millipore
""Sigma-Aldrich Proteins for UGT1A6
"" Browse R&D Systems for human recombinant proteins
""Browse recombinant and purified proteins available from Enzo Life Sciences
""HuPro® and/or Recombinant Proteins from Abnova for UGT1A6 ""
""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
""Novus Biologicals Proteins for UGT1A6  ""
Novus Biologicals Lysate for UGT1A6
""Browse Sino Biological Recombinant Proteins  ""

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane IEA--
GO:0005792 microsome NAS--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for UGT1A6: 
""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
""Sigma-Aldrich Antibodies for UGT1A6
"" Browse R&D Systems for Antibodies
""Monoclonal and Polyclonal Antibodies from Abnova (UGT1A6)
""Browse Origene Antibodies ""
""Novus Biologicals Antibodies for UGT1A6
""Browse antibodies at Epitomics

Assays for UGT1A6: 
""Browse Kits and Assays available from Millipore
""Browse ELISAs at Sigma-Aldrich
"" Browse R&D Systems for biochemical assays
""Browse Enzo Life Sciences for kits & assays

Protein Domains/
Families
for UGT1A6 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR002213 UDP_glucos_trans

Graphical View of Domain Structure for InterPro Entry P19224

ProtoNet protein and cluster: P19224

1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224
Similarity: Belongs to the UDP-glycosyltransferase family

Gene Function
for UGT1A6 gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (UGT1A6)
"" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): UGT1A6
Origene shRNA RFP (see all 2): UGT1A6
Origene basic RS shRNA (see all 2): UGT1A6

""Applied Biosystems Silencer® siRNAs for UGT1A6
""Sigma-Aldrich siRNA for UGT1A6
Sigma-Aldrich shRNA for UGT1A6
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): UGT1A6
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): UGT1A6
Origene untagged cDNA clones in CMV expression vector (see all 2): UGT1A6
""Browse Sino Biological Human cDNA Clones  ""

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds. This isoform has specificity for phenols
Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
Enzyme Number (IUBMB): EC 2.4.1.17 

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0015020 glucuronosyltransferase activity IEA--
GO:0016758 transferase activity, transferring hexosyl groups ----
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Pathways & Interactions
for UGT1A6 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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"" UGT1A6 for pathways           About GeneDecksing

3 "" Millipore Pathways for UGT1A6
  ""  2-Naphthylamine and 2-Nitronaphtalene metabolism
Acetaminophen metabolism
Benzo[a]pyrene metabolism

5/6 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  UGT1A6  (Your Favorite Gene powered by Ingenuity) (see all 6 )
  ""  Retinol Metabolism
Androgen and Estrogen Metabolism
Starch and Sucrose Metabolism
Xenobiotic Metabolism Signaling
Pentose and Glucuronate Interconversions

5/10 "" Kegg Pathways  (Kegg details for UGT1A6) (see all 10 ):
  ""  hsa00040 Pentose and glucuronate interconversions
hsa00053 Ascorbate and aldarate metabolism
hsa00140 Steroid hormone biosynthesis
hsa00500 Starch and sucrose metabolism
hsa00830 Retinol metabolism

"" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT1A6

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006805 xenobiotic metabolic process IDA3141926
GO:0008152 metabolic process NAS--
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Drugs & Compounds
for UGT1A6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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"" UGT1A6 for compounds           About GeneDecksing

"" Browse drugs & compounds from Enzo Life Sciences
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for UGT1A6
10/169 ""Novoseek chemical compound relationships for UGT1A6 gene (see all 169 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
p-nitrophenol 80.90 41 8442763 (3), 2858379 (3), 1914788 (3), 8510012 (2) (see all 30)
1-naphthol 25.80 13 6811722 (2), 19487247 (2), 11317477 (2), 10478938 (2) (see all 9)
uridine diphosphate 18.29 9 19437564 (2), 3148707 (1), 18161889 (1), 17602169 (1) (see all 8)
3-methylcholanthrene 18.11 15 6811722 (2), 3924428 (2), 1914788 (2), 11854140 (2) (see all 11)
acetaminophen 17.95 22 2116803 (5), 17164591 (3), 8510012 (2), 11903872 (2) (see all 12)
tcdd 17.01 18 10220484 (4), 8068691 (3), 19474220 (3), 6428382 (2) (see all 10)
4-methylumbelliferone 15.83 8 9914163 (1), 9429234 (1), 18214896 (1), 17027947 (1) (see all 8)
beta-naphthoflavone 12.97 9 3924428 (3), 16545899 (3), 1914788 (1), 11437649 (1) (see all 5)
5-hydroxytryptophol 10.90 5 15258112 (5)
deferiprone 10.19 6 18318774 (5), 18971318 (1)
About this table

2 PharmGKB drug compound relationships for UGT1A6 gene
Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
acetaminophenPK  GN  15284531
aspirinCO  GN  15770010
About this table


Transcripts
for UGT1A6 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (UGT1A6)
""Applied Biosystems Silencer® siRNAs:  NM_001072  NM_205862  
"" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): UGT1A6
Origene shRNA RFP (see all 2): UGT1A6
Origene basic RS shRNA (see all 2): UGT1A6

""Sigma-Aldrich siRNA for UGT1A6
Sigma-Aldrich shRNA for UGT1A6
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate UGT1A6: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_001072  NM_205862  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): UGT1A6
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): UGT1A6
Origene untagged cDNA clones in CMV expression vector (see all 2): UGT1A6
Primers:"" Origene genome-wide validated SYBR primer pairs: UGT1A6
""SABiosciences RT2 qPCR Primer Assay for UGT1A6: PPH01713A ""

REFSEQ mRNAs for UGT1A6 gene (2 alternative transcripts): 

NM_001072.3  NM_205862.1  

24/271 AceView cDNA sequences (see all 271 ):

NM_000463 BE464379 AV646429 AY435138 AY435143 BE464186 AW297730 CB162031 
AI566081 AY435139 NM_019078 AI913618 AY435144 BM829535 NM_019093 AK025403 
BC043491 AY435140 BE463503 NM_205862 BC053576 AY435136 NM_019077 AI479279 

"" highest scoring ESTs for UGT1A6:

AI439491 AI769507 AI984823 AA405907 AA586566 AI244386 AI244717 AI244891 AI253019 AI282087 


GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A6 (see all 11 )

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1:                    -     -     -     -     -     -     -     -     -     -     -                       -                     
SP2:                                                  -     -     -     -     -     -                       -                     
SP3:        -     -     -     -     -     -     -     -     -     -     -     -     -                       -                     
SP4:                                                        -     -     -     -     -                       -                     
SP5:                                                              -     -     -     -                       -                     

About this scheme

ECgene alternative splicing isoforms for UGT1A6

9 Ensembl transcripts including schematic representations:
ENST00000305139  ENST00000480628  ENST00000373424  ENST00000446481  ENST00000406651  ENST00000478062  
ENST00000441351  ENST00000484784  ENST00000360418  

Expression
for UGT1A6 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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UGT1A6 expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for UGT1A6

1""  / 2""  / 3""

7 probe-sets matching UGT1A6 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
32392_s_at2, 3 U95-A 9 1.00 0.15 1.00 1.00 M57951 0.60 0.06 0.43 2
208596_s_at2, 3 U133-A 9 1.00 0.13 -- -- NM_019093 0.20 0.04 0.14 2
232654_s_at2, 3 U133-B 1 0.91 1.00 -- -- BE873420 0.40 0.37 0.39 1
215125_s_at2, 3 U133-A 9 0.82 0.12 -- -- AV691323 0.20 0.06 0.15 2
208596_s_at2 U133Plus2 9 1.00 0.13 -- -- -- -- -- -- --
232654_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
215125_s_at2 U133Plus2 9 0.82 0.12 -- -- -- -- -- -- --
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Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224
Tissue specificity: Expressed in skin, kidney and liver

Primers:"" Origene genome-wide validated SYBR primer pairs: UGT1A6 ""
""SABiosciences RT2 qPCR Primer Assay for UGT1A6: PPH01713A ""

Orthologs
for UGT1A6 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for UGT1A6 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 UGT1A61   -- UDP glucuronosyltransferase 1 family, polypeptide A6 83.9(n)
81.63(a)		 403629  NM_001003078.1  NP_001003078.1 
chimpanzee
(Pan troglodytes)		 UGT1A61   -- UDP glucuronosyltransferase 1 family, polypeptide A6 99.44(n)
99.44(a)		 739942  XM_001151168.1  XP_001151168.1 
cow
(Bos taurus)		 UGT1A61   -- UDP glucuronosyltransferase 1 family, polypeptide A6 80.03(n)
80.34(a)		 286792  NM_174762.1  NP_777187.1 
rat
(Rattus norvegicus)		 Ugt1a61   -- UDP glucuronosyltransferase 1 family, polypeptide A6 81.7(n)
80.57(a)		 113992  NM_001039691.1  NP_001034780.1 
mouse
(Mus musculus)		 Ugt1a6a1, 5 15
 UDP glucuronosyltransferase 1 family, polypeptide A6A1, 5 81.48(n)1
79.66(a)1		 942841  NM_145079.21  NP_659545.21 
 AK1625145  AY2271975  (see all 10)
About this table        Species with no ortholog for UGT1A6

ENSEMBL Gene Tree for UGT1A6

Paralogs
for UGT1A6 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for UGT1A6 gene
UGT1A82  UGT3A12  UGT1A72  UGT2B72  UGT2B112  UGT1A32  ENSG000002151112  UGT1A12  
UGT1A52  UGT3A22  UGT2A12  UGT2B102  UGT1A102  ENSG000002151102  UGT82  UGT2B152  
UGT2B42  UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  

"" UGT1A6 for paralogs           About GeneDecksing


Genomic Variants
for UGT1A6 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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  User Feedback		UniProtKB/Swiss-Prot: UD16_HUMAN, P19224
Polymorphism: Polymorphisms in the UGT1A6 gene define four common haplotypes: UGT1A6*1, UGT1A6*2, UGT1A6*3 and
UGT1A6*4. Liver tissue samples that were homozygous for UGT1A6*2 exhibited a high rate of glucuronidation relative to
tissues with other genotypes. Biochemical kinetic studies indicate that the UGT1A6*2 allozyme, expressed homozygously,
had almost two-fold greater activity toward p-nitrophenol than UGT1A6*1 and when expressed heterozygously
(UGT1A6*1/*2) it is associated with low enzyme activity. Common genetic variation in UGT1A6 confers functionally
significant differences in biochemical phenotype. This genetic variation might impact clinical efficacy or toxicity of
drugs metabolized by UGT1A6


Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
Database of Genomic Variants (DGV): 10 variations for UGT1A6
     10 CNVs: 90342 90341 61892 35795 50416 39282 37520 39281 63332 90340

Disorders & Mutations
for UGT1A6 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 606431

10/30 ""Novoseek disease relationships for UGT1A6 gene (see all 30 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
colorectal adenoma 7.71 6 17085674 (5), 16797247 (1)
ugt1a1*28 polymorphism 5.67 2 19406951 (1), 17164591 (1)
colonic adenoma 4.57 3 19437564 (3)
colon cancer 4.37 10 19437564 (6), 9762354 (1), 9466822 (1), 19831498 (1) (see all 5)
bleeding peptic ulcer 2.58 2 19799547 (2)
failure right heart 2.07 2 11046125 (2)
upper gastrointestinal symptoms 1.63 1 16305586 (1)
autoimmune hepatitis 1.39 2 11343231 (2)
feminization 1.34 1 110198 (1)
scorbutic 1.27 1 2108683 (1)
About this table

1 PharmGKB disease relationship for UGT1A6 gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Colorectal NeoplasmsCO  GN  15770010
About this table

Human Gene Mutation Database: UGT1A6
Genetic Association Database: UGT1A6
Human Genome Epidemiology Navigator: UGT1A6 (42 documents)

Medical News
for UGT1A6 gene

(Possibly Related Articles in Doctor's Guide)
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Publications
for UGT1A6 gene

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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  User Feedback		10/178 PubMed articles for UGT1A6 gene (see all 178 ):

Search for UGT1A6 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
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Genome Databases showing UGT1A6 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54578 HGNC: 12538 AceView: UGT1A1 Ensembl:ENSG00000167165 euGenes: HUgn54578
ECgene: UGT1A6 Kegg: 54578 H-InvDB: UGT1A6

Other Databases showing UGT1A6 gene

(According to HUGE)
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Specialized Databases showing UGT1A6 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property
for UGT1A6 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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  User Feedback		Patent Information for UGT1A6 gene: ""
Search GeneIP for patents involving UGT1A6

GeneCards and IP: ""
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


Services
for UGT1A6 gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UGT1A6:
"" TaqMan ® Gene Expression Assays
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"" Search Tocris compounds for UGT1A6
"" Regulatory tfbs in UGT1A6 upstream (promoter) region
"" Search Chromatin IP Primers for UGT1A6
"" Search DNA Methylation qPCR Primer Assays for UGT1A6
"" RT2 qPCR Primer Assay for UGT1A6
"" GNC Network for UGT1A6
"" Search for microRNAs that regulate UGT1A6
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"" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
"" Novus Tissue Slides
"" Antibodies for UGT1A6
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"" Browse Sino Biological cDNA Clones
"" Antibodies/Proteins Production Services
"" Rabbit Monoclonal Antibody Platform
"" Bulk Purchasing
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