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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UGT1A6 Gene

protein-coding GIFtS: 57
GCID: GC02P234600

UDP glucuronosyltransferase 1 family, polypeptide A6

(Previous names: UDP glycosyltransferase 1 family, polypeptide A6 )

Explore 36 diseases affiliated with
UGT1A6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A6¹ ²		UGT1.6² ³
GNT1¹ ² ³		UDP-Glucuronosyltransferase 1-F² ³
UGT1F¹ ² ³		UDP-Glucuronosyltransferase 1A6² ³
HLUGP¹ ²		UDPGT 1-6² ³
UDP Glycosyltransferase 1 Family, Polypeptide A6¹ ²		EC 2.4.1.17³ ⁸
Phenol-Metabolizing UDP-Glucuronosyltransferase² ³		HLUGP1²
UGT-1F² ³		UDPGT²
UGT1² ³		UGT1A6S²
UGT1*6² ³		UDP-Glucuronosyltransferase 1 Family Polypeptide A6s²
UGT1-06² ³		UDP-Glucuronosyltransferase 1-6²

External Ids:	HGNC: 12538¹	Entrez Gene: 54578²	Ensembl: ENSG00000167165⁷	OMIM: 606431⁵	UniProtKB: P19224³

Export aliases for UGT1A6 gene to outside databases

Previous GC identifers: GC02U990248 GC02P234819 GC02P234882 GC02P234367 GC02P234382 GC02P234197 GC02P234208 GC02P234217 GC02P234265 GC02P226400

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGT1A6:

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small

lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.

This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen

unique alternate first exons followed by four common exons. Four of the alternate first exons are considered

pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins

with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated

by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing

in the unique 5' end of this gene results in two transcript variants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics

and endogenous compounds. This isoform has specificity for phenols

Gene Wiki entry for UGT1A6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UGT1A6 gene promoter:
p53 AP-1 ATF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for UGT1A6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37

UGT1A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A6 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P234600: view genomic region (about GC identifiers)

Start:	234,600,253 bp from pter	End:	234,681,951 bp from pter
Size:	81,699 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224 (See protein sequence)

Recommended Name: UDP-glucuronosyltransferase 1-6 precursor

Size: 532 amino acids; 60751 Da

Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)

Sequence caution: Sequence=BM924331; Type=Erroneous termination; Positions=420; Note=Translated as Glu;

Sequence=BM924331; Type=Frameshift; Positions=451, 463; Sequence=BM924331; Type=Miscellaneous discrepancy;

Note=Probable cloning artifact;

Secondary accessions: A6NKK6 Q96TE7

Alternative splicing: 2 isoforms: P19224-1 P19224-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UGT1A6: NX_P19224

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P19224

4/21 DME Specific Peptides for UGT1A6 (P19224) (see all 21)

FWVEFVM

QYHSLDV

DVIGFLL

GSHWLSM

UGT1A6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001063.2 NP_995584.1

ENSEMBL proteins:

ENSP00000362523 ENSP00000389637 ENSP00000401541 ENSP00000303174 ENSP00000419780

ENSP00000386107

Reactome Protein details: P19224
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	Uscn Proteins for UGT1A6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0016021	integral to membrane	IEA	--
GO:0043231	intracellular membrane-bounded organelle	NAS	--

UGT1A6 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for UGT1A6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UGT1A6 for domains About GeneDecksing

1 InterPro domain/family:

IPR002213 UDP_glucos_trans

Graphical View of Domain Structure for InterPro Entry P19224

ProtoNet protein and cluster: P19224

1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224

Similarity: Belongs to the UDP-glycosyltransferase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics

and endogenous compounds. This isoform has specificity for phenols

Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

Enzyme Number (IUBMB): EC 2.4.1.17¹ ²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A6

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001972	NOT retinoic acid binding	IDA	--
GO:0015020	glucuronosyltransferase activity	IEA	--
GO:0016758	transferase activity, transferring hexosyl groups	--	--
GO:0019899	enzyme binding	IDA	--
GO:0042803	protein homodimerization activity	IPI	--

UGT1A6 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glucuronidation

Glucuronidation	1.00	Porphyrin and chlorophyll metabolism	0.38
Glucuronidation	0.67	Other types of O-glycan biosynthesis	0.36
Starch and sucrose metabolism	0.42	Drug metabolism - other enzymes	0.32

Acetaminophen Pathway, Pharmacokinetics

	Pathway_PA165986194 -need delete	1.00			Acetaminophen metabolism	0.43
	Acetaminophen Pathway, Pharmacokinetics	1.00			Acetaminophen metabolism	0.43

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

2-Naphthylamine and 2-Nitronaphtalene metabolism

2-Naphthylamine and 2-Nitronaphtalene metabolism

1.00

2-Naphthylamine and 2-Nitronaphtalene metabolism

0.95

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for UGT1A6

	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Acetaminophen metabolism
	Benzo[a]pyrene metabolism

3 GeneGo (Thomson Reuters) Pathways for UGT1A6

	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Benzo[a]pyrene metabolism
	Acetaminophen metabolism

5 BioSystems Pathways for UGT1A6

	Irinotecan Pathway
	Glucuronidation
	Estrogen metabolism
	metapathway biotransformation
	Oxidative Stress

4 Reactome Pathways for UGT1A6

	Metabolism
	Biological oxidations
	Phase II conjugation
	Glucuronidation

5 PharmGKB Pathways for UGT1A6

	Acetaminophen Pathway, Pharmacokinetics
	Irinotecan Pathway, Pharmacodynamics
	Pathway_PA165986194 -need delete
	Phenytoin Pathway, Pharmacokinetics
	Valproic Acid Pathway, Pharmacokinetics

5/11 Kegg Pathways (Kegg details for UGT1A6) (see all 11):

	Pentose and glucuronate interconversions
	Ascorbate and aldarate metabolism
	Steroid hormone biosynthesis
	Starch and sucrose metabolism
	Other types of O-glycan biosynthesis

UGT1A6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UGT1A6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/56 Interacting proteins for UGT1A6 (ENSP00000303174⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADH1A	ENSP00000209668⁴	STRING: ENSP00000209668
ADH1B	ENSP00000306606⁴	STRING: ENSP00000306606
ADH4	ENSP00000265512⁴	STRING: ENSP00000265512
ADH7	ENSP00000209665⁴	STRING: ENSP00000209665
ALDH1A1	ENSP00000297785⁴	STRING: ENSP00000297785

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0008152	metabolic process	NAS	--
GO:0044281	small molecule metabolic process	TAS	--

UGT1A6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UGT1A6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UGT1A6

10/85 HMDB Compounds for UGT1A6 (see all 85) About this table

Compound	Synonyms	CAS #	PubMed Ids
Acetaminophen glucuronide	4-acetamidophenyl b-D-glucopyranosiduronic acid (see all 8)	16110-10-4	11903872 11714888
Ethyl glucuronide		17685-04-0	16139098
Retinyl beta-glucuronide	Retinyl b-glucuronide (see all 2)	--	8600986
Valproic acid glucuronide	1-(2-propylpentanoate) beta-D-Glucopyranuronate (see all 18)	60113-83-9	12732356
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)	(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)	--	--
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid	Ibuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)	115075-59-7	--
1-Salicylate glucuronide	1-salicylic acid glucuronide	--	--
11-Hydroxyprogesterone 11-glucuronide	11-hydroxyprogesterone 11-glucuronoside (see all 5)	77710-64-6	--
11-Oxo-androsterone glucuronide	11-oxo-etiocholanolone glucuronide (see all 3)	--	--
11-beta-hydroxyandrosterone-3-glucuronide	11-beta-hydroxyetiocholanolone-3-glucuronide	--	--

10/34 Novoseek chemical compound relationships for UGT1A6 gene (see all 34) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
4-methylumbelliferone	88.9	11	9058595 (1), 10220484 (1), 16545899 (1), 17027947 (1) (see all 7)
udp glucuronic acid	86.1	2	9058595 (1), 9107538 (1)
1-naphthol	83.9	9	8161205 (2), 11317477 (2), 19487247 (1), 11437353 (1) (see all 7)
uridine diphosphate	81.8	6	16802850 (1), 19437564 (1), 18161889 (1), 16797247 (1) (see all 5)
glucuronide	74.2	4	9762354 (1), 17359941 (1), 11560872 (1), 11408353 (1)
beta-naphthoflavone	72.5	7	16545899 (3), 10901286 (1), 11437649 (1), 8738480 (1)
p-nitrophenol	71.3	5	12695347 (1), 10471066 (1), 12386132 (1), 9107538 (1) (see all 5)
n-hydroxy phip	68.6	2	11375903 (1)
4-hydroxycoumarin	65.4	1	10471066 (1)
3-methylcholanthrene	62.8	6	8689937 (1), 11274859 (1), 19525444 (1), 11437649 (1)

1 PharmGKB related drug/compound annotation for UGT1A6 gene

Drug/compound	PharmGKB Annotation
valproic acid	CA

About this table

Search CenterWatch for drugs/clinical trials and news about UGT1A6 / UD16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for UGT1A6 gene (2 alternative transcripts):

NM_001072.3 NM_205862.1

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373424 ENST00000441351 ENST00000480628 ENST00000446481 ENST00000305139(uc002vuu.3 uc002vuv.4)

ENST00000484784 ENST00000478062 ENST00000406651

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24/271 AceView cDNA sequences (see all 271):

NM_019077 AY435142 BE464422 CB162031 AV660038 CB163625 BC053576 BE464186

AI913618 NM_000463 AV650286 BI764371 NM_019093 AY435143 AV646429 CB163341

AI767337 NM_019078 BE463503 AY435144 AY435140 NM_019075 AK025403 NM_007120

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A6 (see all 11) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	·	15c
SP1:							-		-		-		-		-		-		-		-		-		-		-								-
SP2:																	-		-		-		-		-		-								-
SP3:			-		-		-		-		-		-		-		-		-		-		-		-		-								-
SP4:																			-		-		-		-		-								-
SP5:																					-		-		-		-								-

ECgene alternative splicing isoforms for UGT1A6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UGT1A6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

UGT1A6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UGT1A6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UGT1A6

UniProtKB/Swiss-Prot: UD16_HUMAN, P19224

Tissue specificity: Expressed in skin, kidney and liver

SABiosciences Custom PCR Arrays for UGT1A6

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for UGT1A6 gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1P1M7_CHICK⁶ -- (see all 5)	Uncharacterized protein (see all 5)	59(a) 46(a) (see all 5)	possible ortholog possible ortholog (see all 5)	7(5795449-5817899) 7(5834824-5835693)
lizard (Anolis carolinensis)	Reptilia	-- UGT1A6⁶ (see all 3)	--	60(a) 59(a) (see all 3)	possible ortholog possible ortholog (see all 3)	1(118894319-118901649) 1(118848249-118849106)
zebrafish (Danio rerio)	Actinopterygii	ugt1ab⁶ ugt1b4⁶	UDP glucuronosyltransferase 1 family a, b UDP glucuronosyltransferase 1 family, polypeptide ...	51(a) 48(a)	many ↔ many many ↔ many	9(10194767-10228512) 11(31171792-31204741)

ENSEMBL Gene Tree for UGT1A6 (if available)
TreeFam Gene Tree for UGT1A6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for UGT1A6 gene

UGT2A2² UGT1A8² UGT1A7² UGT3A1² UGT2B7² UGT2B11² UGT1A3² UGT1A1²

UGT1A5² UGT3A2² UGT2B10² UGT1A10² UGT8² UGT2B15² UGT2B4² UGT2B17²

UGT2A3² UGT2B28² UGT1A9² UGT1A4²

18/30 SIMAP similar genes for UGT1A6 using alignment to 6 protein entries: UD16_HUMAN (see all proteins) (see all similar genes):

UGT1A6S UGT1A3S UGT1A9S UGT1A8S UGT1A10 UGT1A1

BILIQTL1 UGT1A4S UGT1A8 UGT1A9 UGT2A3 UGT1A4

UGT2B7 UGT1A5 UGT1A7 UGT2B4 UGT2B17 UGT1A3

UGT1A6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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UniProtKB/Swiss-Prot: UD16_HUMAN, P19224

Polymorphism: Polymorphisms in the UGT1A6 gene define four common haplotypes: UGT1A6*1, UGT1A6*2, UGT1A6*3 and

UGT1A6*4. Liver tissue samples that were homozygous for UGT1A6*2 exhibited a high rate of glucuronidation relative to

tissues with other genotypes. Biochemical kinetic studies indicate that the UGT1A6*2 allozyme, expressed homozygously,

had almost two-fold greater activity toward p-nitrophenol than UGT1A6*1 and when expressed heterozygously

(UGT1A6*1/*2) it is associated with low enzyme activity. Common genetic variation in UGT1A6 confers functionally

significant differences in biochemical phenotype. This genetic variation might impact clinical efficacy or toxicity of

drugs metabolized by UGT1A6

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for UGT1A6
10 CNVs: 90342 90341 61892 35795 50416 39282 37520 39281 63332 90340
Human Gene Mutation Database (HGMD): UGT1A6

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UGT1A6 for disorders           About GeneDecksing

OMIM gene information: 606431    OMIM disorders: --

20/36 diseases for UGT1A6 (see all 36):    About MalaCards

crigler-najjar syndrome crigler najjar syndrome, type 2 drug-induced hepatitis familial adenomatous polyposis

neonatal jaundice peptic ulcer gilbert syndrome kernicterus

bronchial asthma hearing loss epithelial ovarian cancer cholelithiasis

hodgkin's lymphoma polyposis autoimmune hepatitis jaundice

ovarian cancer neutropenia colorectal cancer diarrhea

7 diseases from the University of Copenhagen DISEASES database for UGT1A6:

Bilirubin metabolic disorder Neonatal jaundice Neutropenia Diarrhea

Colorectal cancer Kernicterus Cholelithiasis

6 Novoseek disease relationships for UGT1A6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	48.6	4	9762354 (1), 10220484 (1), 9466822 (1), 19831498 (1)
colon adenocarcinoma	24.2	1	15826610 (1)
adenoma	18.5	9	17085674 (5), 19437564 (3), 16797247 (1)
lung carcinoma	9.04	1	9466822 (1)
tumors	2.04	3	15709193 (1), 17085674 (1), 19448967 (1)
colorectal cancer	0	4	16797247 (4)

Genetic Association Database (GAD): UGT1A6
Human Genome Epidemiology (HuGE) Navigator: UGT1A6 (51 documents)

Export disorders for UGT1A6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for UGT1A6 gene, integrated from 9 sources (see all 209):
(articles sorted by number of sources associating them with UGT1A6)

Utopia: connect your pdf to the dynamic
world of online information

Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. (PubMed id 15284531)^{1, 2, 4, 9} Nagar S.... Blanchard R.L. (2004)
A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. (PubMed id 1339448)^{1, 2, 3} Ritter J.K....Owens I.S. (1992)
Genetic polymorphism in the human UGT1A6 (planar phenol) UDP- glucuronosyltransferase: pharmacological implications. (PubMed id 9429234)^{1, 2, 9} Ciotti M.... Owens I.S. (1997)
UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation. (PubMed id 15761114)^{1, 4, 9} Krishnaswamy S....Court M.H. (2005)
Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6. (PubMed id 9466822)^{1, 2, 9} Muenzel P.A.... Bock K.W. (1998)
Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. (PubMed id 11714888)^{1, 6, 9} Court M.H....Mackenzie P.I. (2001)
No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma. (PubMed id 16141797)^{1, 4, 9} McGreavey L.E....Barrett J.H. (2005)
Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (PubMed id 15247627)^{1, 4, 9} Verlaan M....Drenth J.P. (2004)
Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. (PubMed id 15319294)^{1, 4, 9} van der Logt E.M....Peters W.H. (2004)
Urinary excretion of phenytoin metabolites, 5-(4'-hydroxyphenyl)-5-phenylhydantoin and its O-glucuronide in humans and analysis of genetic polymorphisms of UDP-glucuronosyltransferases. (PubMed id 15855726)^{1, 4, 9} Yamanaka H....Yokoi T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54578	HGNC: 12538	AceView: UGT1A1	Ensembl:ENSG00000167165	euGenes: HUgn54578
ECgene: UGT1A6	Kegg: 54578	H-InvDB: UGT1A6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for UGT1A6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UGT1A6 gene
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Patent Information for UGT1A6 gene:
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UGT1A6 Gene

UDP glucuronosyltransferase 1 family, polypeptide A6

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UGT1A6 (Gene Symbol)
UDP Glucuronosyltransferase 1 Family, Polypeptide A6
GNT1
UGT1F
HLUGP
UDP Glycosyltransferase 1 Family, Polypeptide A6
Phenol-Metabolizing UDP-Glucuronosyltransferase
UGT-1F
UGT1
UGT1*6
UGT1-06
UGT1.6
UDP-Glucuronosyltransferase 1-F
UDP-Glucuronosyltransferase 1A6
UDPGT 1-6
EC 2.4.1.17
HLUGP1
UDPGT
UGT1A6S
UDP-Glucuronosyltransferase 1 Family Polypeptide A6s
UDP-Glucuronosyltransferase 1-6

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UGT1A6 Gene

UDP glucuronosyltransferase 1 family, polypeptide A6

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