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Aliases for UGT1A5 Gene

Aliases for UGT1A5 Gene

  • UDP Glucuronosyltransferase Family 1 Member A5 2 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A5 2 3
  • UDP-Glucuronosyltransferase 1-E 3 4
  • UDP-Glucuronosyltransferase 1A5 3 4
  • EC 4 61
  • UDPGT 1-5 3 4
  • UGT-1E 3 4
  • UGT1*5 3 4
  • UGT1E 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A5 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A5s 3
  • UDP-Glucuronosyltransferase 1-5 3
  • UGT1-05 4
  • UGT1.5 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A5 Gene

Previous GeneCards Identifiers for UGT1A5 Gene

  • GC02U990249
  • GC02P234818
  • GC02P234881
  • GC02P234366
  • GC02P234403
  • GC02P234196
  • GC02P234206
  • GC02P234216
  • GC02P234286
  • GC02P234621
  • GC02P226422

Summaries for UGT1A5 Gene

Entrez Gene Summary for UGT1A5 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A5 Gene

UGT1A5 (UDP Glucuronosyltransferase Family 1 Member A5) is a Protein Coding gene. Diseases associated with UGT1A5 include Pericholangitis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT1A3.

UniProtKB/Swiss-Prot for UGT1A5 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).

Gene Wiki entry for UGT1A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A5 Gene

Genomics for UGT1A5 Gene

Regulatory Elements for UGT1A5 Gene

Enhancers for UGT1A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F233711 0.4 Ensembl 0.8 -1.4 -1392 0.4 CTCF ZSCAN9 RAD21 ZNF143 SMC3 ZNF263 GATAD2A ZNF654 TRIM22 REST USP40 ENSG00000224814 UGT1A5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UGT1A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT1A5 Gene

233,712,992 bp from pter
233,773,299 bp from pter
60,308 bases
Plus strand

Genomic View for UGT1A5 Gene

Genes around UGT1A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A5 Gene

Proteins for UGT1A5 Gene

  • Protein details for UGT1A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucuronosyltransferase 1-5
    Protein Accession:
    Secondary Accessions:
    • B8K294

    Protein attributes for UGT1A5 Gene

    534 amino acids
    Molecular mass:
    60071 Da
    Quaternary structure:
    No Data Available
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A5 Gene


neXtProt entry for UGT1A5 Gene

Selected DME Specific Peptides for UGT1A5 Gene


Post-translational modifications for UGT1A5 Gene

  • Glycosylation at Asn 119, Asn 296, and Asn 348
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT1A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A5 Gene

Gene Families for UGT1A5 Gene

Protein Domains for UGT1A5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UDP-glycosyltransferase family.
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A5: view

Function for UGT1A5 Gene

Molecular function for UGT1A5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).

Enzyme Numbers (IUBMB) for UGT1A5 Gene

Gene Ontology (GO) - Molecular Function for UGT1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT1A5: view
genes like me logo Genes that share phenotypes with UGT1A5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A5 Gene

Localization for UGT1A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A5 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for UGT1A5 Gene COMPARTMENTS Subcellular localization image for UGT1A5 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 2
nucleus 2
peroxisome 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UGT1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 NOT intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT1A5: view

Pathways & Interactions for UGT1A5 Gene

genes like me logo Genes that share pathways with UGT1A5: view

Pathways by source for UGT1A5 Gene

Interacting Proteins for UGT1A5 Gene

Gene Ontology (GO) - Biological Process for UGT1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009813 flavonoid biosynthetic process IBA --
GO:0052696 flavonoid glucuronidation IBA --
GO:0052697 xenobiotic glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT1A5: view

No data available for SIGNOR curated interactions for UGT1A5 Gene

Drugs & Compounds for UGT1A5 Gene

(18) Drugs for UGT1A5 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Allopurinol Approved Pharma 137
Daunorubicin Approved Pharma DNA topoisomerase II inhibitor 264
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1714
Febuxostat Approved Pharma Xanthine oxidase inhibitor 52
Codeine Approved, Illicit Pharma Full agonist, Agonist 74

(81) Additional Compounds for UGT1A5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT1A5: view

Transcripts for UGT1A5 Gene

mRNA/cDNA for UGT1A5 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A5 Gene

No ASD Table

Relevant External Links for UGT1A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UGT1A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT1A5 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x27.0) and Bladder (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of UGT1A5 Gene:


mRNA Expression by UniProt/SwissProt for UGT1A5 Gene:

Tissue specificity: Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus.
genes like me logo Genes that share expression patterns with UGT1A5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for UGT1A5 Gene

Orthologs for UGT1A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UGT1A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
(Rattus norvegicus)
Mammalia Ugt1a3 34
  • 78.87 (n)
(Mus musculus)
Mammalia Ugt1a5 35
  • 75 (a)
Ugt1a2 35
  • 74 (a)
(Bos Taurus)
Mammalia -- 35
  • 67 (a)
-- 35
  • 64 (a)
-- 35
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
(Danio rerio)
Actinopterygii ugt1a7 35
  • 50 (a)
ugt1b1 35
  • 48 (a)
ugt1b3 35
  • 46 (a)
ugt1b4 35
  • 46 (a)
ugt1b5 35
  • 46 (a)
ugt1b2 35
  • 45 (a)
Species where no ortholog for UGT1A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UGT1A5 Gene

Gene Tree for UGT1A5 (if available)
Gene Tree for UGT1A5 (if available)

Paralogs for UGT1A5 Gene

Variants for UGT1A5 Gene

Sequence variations from dbSNP and Humsavar for UGT1A5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2011425 drug-response 233,718,962(+) AGGCC(G/T)TGCGG intron-variant, reference, missense
rs887829 drug-response 233,759,924(-) TTCCA(A/G)AAATT intron-variant, upstream-variant-2KB
rs111033539 Pathogenic 233,767,160(+) TCCCT(C/T)AGACA reference, stop-gained
rs111033541 Pathogenic 233,760,331(+) GGGCC(G/T)GCTGC intron-variant, reference, missense
rs281865418 Pathogenic 233,761,127(+) AACTG(A/C/G)CTTCA intron-variant, reference, missense, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for UGT1A5 Gene

Variant ID Type Subtype PubMed ID
dgv769e199 CNV deletion 23128226
esv2422005 CNV deletion 20811451
esv25622 CNV loss 19812545
esv2661542 CNV deletion 23128226
esv2721667 CNV deletion 23290073
esv2721668 CNV deletion 23290073
esv2721669 CNV deletion 23290073
esv2760613 CNV loss 21179565
esv2760615 CNV loss 21179565
esv3561178 CNV deletion 23714750
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv1126580 CNV deletion 24896259
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584705 CNV loss 21841781
nsv961573 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv963781 CNV duplication 23825009
nsv963782 CNV duplication 23825009
nsv979186 CNV duplication 23825009
nsv979187 CNV duplication 23825009

Variation tolerance for UGT1A5 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.03; 90.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT1A5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A5 Gene

Disorders for UGT1A5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UGT1A5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT1A5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UGT1A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A5 Gene

Publications for UGT1A5 Gene

  1. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. (PMID: 1339448) Ritter J.K. … Owens I.S. (J. Biol. Chem. 1992) 2 3 4 64
  2. UGT1A1 is a major locus influencing bilirubin levels in African Americans. (PMID: 22085899) Chen G. … Rotimi C.N. (Eur. J. Hum. Genet. 2012) 3 46 64
  3. A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study. (PMID: 22511988) JylhAovAo J. … Hurme M. (PLoS ONE 2012) 3 46 64
  4. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. (PMID: 22558097) Milton J.N. … Klings E.S. (PLoS ONE 2012) 3 46 64
  5. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PMID: 21646302) Bielinski S.J. … Chute C.G. (Mayo Clin. Proc. 2011) 3 46 64

Products for UGT1A5 Gene

Sources for UGT1A5 Gene

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