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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT1A5 Gene

protein-coding   GIFtS: 50
GCID: GC02P234621

UDP Glucuronosyltransferase 1 Family, Polypeptide A5

(Previous names: UDP glycosyltransferase 1 family, polypeptide A5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A51 2     EC 2.4.1.173 8
UDP Glycosyltransferase 1 Family, Polypeptide A51 2     UDPGT2
UGT-1E2 3     UDP-Glucuronosyltransferase 1 Family Polypeptide A5s2
UGT1*52 3     UDP-Glucuronosyltransferase 1-52
UGT1E2 3     GNT13
UDP-Glucuronosyltransferase 1-E2 3     UGT13
UDP-Glucuronosyltransferase 1A52 3     UGT1-053
UDPGT 1-52 3     UGT1.53

External Ids:    HGNC: 125371   Entrez Gene: 545792   Ensembl: ENSG000002402247   OMIM: 6064305   UniProtKB: P355043   

Export aliases for UGT1A5 gene to outside databases

Previous GC identifers: GC02U990249 GC02P234818 GC02P234881 GC02P234366 GC02P234403 GC02P234196 GC02P234206 GC02P234216 GC02P234286 GC02P226422


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGT1A5 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A5 Gene: 
UGT1A5 (UDP glucuronosyltransferase 1 family, polypeptide A5) is a protein-coding gene. Diseases associated with UGT1A5 include neonatal jaundice, and kernicterus, and among its related super-pathways are Ascorbate and aldarate metabolism and Phase II conjugation. GO annotations related to this gene include glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD15_HUMAN, P35504
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds

Gene Wiki entry for UGT1A5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT1A5 gene promoter:
         STAT1   PPAR-gamma1   p53   STAT2   STAT1beta   PPAR-gamma2   STAT1alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UGT1A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234621:  view genomic region     (about GC identifiers)

Start:
234,621,638 bp from pter      End:
234,681,945 bp from pter
Size:
60,308 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UD15_HUMAN, P35504 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-5 precursor  
Size: 534 amino acids; 60071 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Alternative splicing: 1 isoform:  P35504-1   

Explore the universe of human proteins at neXtProt for UGT1A5: NX_P35504

Explore proteomics data for UGT1A5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35504

  • 4/21 DME Specific Peptides for UGT1A5 (P35504) (see all 21)
     FWVEFVM  QYHSLDV  DVIGFLL  GSHWLSM 

    UGT1A5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGT1A5 Protein Expression
    REFSEQ proteins: NP_061951.1  
    ENSEMBL proteins: 
     ENSP00000362513  
    Reactome Protein details: P35504
    Human Recombinant Protein Products for UGT1A5: 
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0043231intracellular membrane-bounded organelle NAS--

    UGT1A5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P35504

    ProtoNet protein and cluster: P35504

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD15_HUMAN, P35504
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT1A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD15_HUMAN, P35504
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015020glucuronosyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0030246carbohydrate binding ----
         
    UGT1A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT1A5:
     Increased cell number in G1, s 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UGT1A5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.67
    Starch and sucrose metabolism0.41
    Glucuronidation0.67
    Porphyrin and chlorophyll metabolism0.38
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.33
    Pentose and glucuronate interconversions0.61
    Steroid hormone biosynthesis0.30
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    Retinol metabolism0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UGT1A5
        Glucuronidation
    metapathway biotransformation


    4        Reactome Pathways for UGT1A5
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation


    5/11         Kegg Pathways  (Kegg details for UGT1A5) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT1A5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT1A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT1A5 (ENSP000003625134) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    BLVRAENSP000002655234STRING: ENSP00000265523
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006805xenobiotic metabolic process NAS--
    GO:0008152metabolic process NAS--
    GO:0030259lipid glycosylation ----

    UGT1A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT1A5 (UD15)

    10/83 HMDB Compounds for UGT1A5 (see all 83)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----

    Search CenterWatch for drugs/clinical trials and news about UGT1A5 / UD15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGT1A5 gene: 
    NM_019078.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373414(uc010zmz.1 uc002vuw.3)
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    24/271 AceView cDNA sequences (see all 271):

    BE464379 CB162031 CB157019 BC043491 BI764371 AI479279 AY435142 BE464422 
    NM_019077 AY435136 NM_021027 CB163625 NM_019076 AW297730 BG165230 AY435138 
    NM_007120 AU076863 NM_001072 AI478649 CB163341 AY435144 NM_000463 BC053576 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT1A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A5 Expression
    About this image


    See UGT1A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT1A5
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A5 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a55 UDP glucuronosyltransferase 1 family, polypeptide A5   --   1 (44.53 cM) 88166012 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    1(118864159-118904238)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1ab6
    ugt1b46
    UDP glucuronosyltransferase 1 family a, b
    UDP glucuronosyltransferase 1 family, polypeptide ...
    51(a)
    45(a)
    many ↔ many
    many ↔ many
    9(10194767-10228512)
    11(31171792-31204741)


    ENSEMBL Gene Tree for UGT1A5 (if available)
    TreeFam Gene Tree for UGT1A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT1A5 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A32  UGT1A12  
    UGT3A22  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    18/30 SIMAP similar genes for UGT1A5 using alignment to 12 protein entries:     UD15_HUMAN (see all proteins) (see all similar genes):
    UGT1A3S    UGT1A3    UGT1A4S    UGT1A4    UGT1A9S    UGT1
    BILIQTL1    UGT1A1    UGT1A8S    UGT2A3    UGT2B17    UGT1A6
    UGT2B11    UGT2B28    UGT2B10    UGT1A6S    UGT1A10    UGT1A8

    UGT1A5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    9 SNPs in UGT1A5 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0524564
    ----see VAR_0524562 L P mis40--------
    VAR_0524604
    ----see VAR_0524602 V L mis40--------
    VAR_0524574
    ----see VAR_0524572 T S mis40--------
    VAR_0598464
    ----see VAR_0598462 H N mis40--------
    VAR_0524584
    ----see VAR_0524582 A G mis40--------
    VAR_0524614
    ----see VAR_0524612 G R mis40--------
    VAR_0524594
    ----see VAR_0524592 H Y mis40--------
    VAR_0524554
    ----see VAR_0524552 L S mis40--------
    VAR_0598454
    ----see VAR_0598452 D E mis40--------

    HapMap Linkage Disequilibrium report for UGT1A5 (234621638 - 234681945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for UGT1A5 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2661542CNV Deletion23128226
    esv2721669CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721668CNV Deletion23290073
    esv2721667CNV Deletion23290073
    nsv498958CNV Loss21111241
    nsv876017CNV Loss21882294
    esv8142CNV Loss19470904
    nsv519815CNV Loss19592680


    Human Gene Mutation Database (HGMD): UGT1A5
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606430    OMIM disorders: --

    9 diseases for UGT1A5:    About MalaCards
    neonatal jaundice    kernicterus    jaundice    cholelithiasis
    sickle cell anemia    cytochrome p450    metabolic disorders    anemia
    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for UGT1A5:
    Bilirubin metabolic disorder     Kernicterus

    UGT1A5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UGT1A5
    Human Genome Epidemiology (HuGE) Navigator: UGT1A5 (5 documents)

    Export disorders for UGT1A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT1A5 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with UGT1A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. (PubMed id 1339448)1, 2, 3 Ritter J.K....Owens I.S. (1992)
    2. UGT1A1 is a major locus influencing bilirubin levels i n African Americans. (PubMed id 22085899)1, 4 Chen G....Rotimi C.N. (2012)
    3. A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Yo ung Finns Study. (PubMed id 22511988)1, 4 Jylhava J....Hurme M. (2012)
    4. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. (PubMed id 22558097)1, 4 Milton J.N....Klings E.S. (2012)
    5. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circ ulating bilirubin levels. (PubMed id 21646302)1, 4 Bielinski S.J....Chute C.G. (2011)
    6. Human metabolic individuality in biomedical and pharma ceutical research. (PubMed id 21886157)1, 4 Suhre K....Gieger C. (2011)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (2009)
    9. Common variants in the SLCO1B3 locus are associated w ith bilirubin levels and unconjugated hyperbilirubinemia. (PubMed id 19419973)1, 4 Sanna S....Uda M. (2009)
    10. Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)1, 4 Johnson A.D....Witteman J.C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54579 HGNC: 12537 AceView: UGT1A1 Ensembl:ENSG00000240224 euGenes: HUgn54579
    ECgene: UGT1A5 Kegg: 54579 H-InvDB: UGT1A5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT1A5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGT1A5 gene:
    Search GeneIP for patents involving UGT1A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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