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UGT1A4 Gene

protein-coding GIFtS: 50

GC02P234215

UDP glucuronosyltransferase 1 family, polypeptide A4
(Previous names: UDP glycosyltransferase 1 family, polypeptide A4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.4.1.17 ^³
GNT1 ^³
HUG-BR2 ^¹, ², ³
UDP-glucuronosyltransferase ^²
UDPGT ^², ³
UGT-1D ^³
UGT1 ^³
UGT1*4 ^³
UGT1-04 ^³
UGT1.4 ^³
UGT1D ^¹, ², ³, ⁵

Descriptions
Bilirubin-specific UDPGT isozyme 2 ^³
UDP glucuronosyltransferase 1 family, polypeptide A4 ^²
UDP glycosyltransferase 1 family, polypeptide A4 ^¹, ²
UDP-glucuronosyltransferase 1A4 ^³
bilirubin UDP-glucuronosyltransferase isozyme 2 ^²

External Ids
HGNC: 12536¹
Entrez Gene: 54657²
UniProtKB: P22310³
Ensembl: ENSG00000167165⁷

Search outside databases for aliases for UGT1A4 gene

Previous GC identifers: GC02U990252 GC02P234817 GC02P234880 GC02P234365 GC02P234409 GC02P234195 GC02P234205

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UGT1A4:

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that

transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into

water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several

UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by

four common exons. Four of the alternate first exons are considered pseudogenes. Each of the

remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins

with different N-termini and identical C-termini. Each first exon encodes the substrate binding

site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards

bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq]

UniProtKB/Swiss-Prot: UD14_HUMAN, P22310

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially

toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form

both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

Gene Wiki entry for UGT1A4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UGT1A4 gene

Entrez Gene cytogenetic band: 2q37 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37

UGT1A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P234215: (about GC identifiers)

Start:	234,191,093 bp from pter
End:	234,346,688 bp from pter
Size:	155,596 bases
Orientation:	plus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UD14_HUMAN, P22310 (See protein sequence)

Recommended Name: UDP-glucuronosyltransferase 1-4 precursor

Size: 534 amino acids; 60025 Da

Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein

(Potential)

Alternative splicing: 1 isoform: P22310-1 (A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues)

REFSEQ proteins: NP_009051.1

ENSEMBL proteins:

ENSP00000343838 ENSP00000362549 ENSP00000362544 ENSP00000346768 ENSP00000362559 ENSP00000362525

ENSP00000303174 ENSP00000353593 ENSP00000362523 ENSP00000386107 ENSP00000362513 ENSP00000327082

ENSP00000362508 ENSP00000304845

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (UGT1A4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	1898728
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for UGT1A4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UGT1A4
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for UGT1A4

Assays for UGT1A4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22310

ProtoNet protein and cluster: P22310

1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

UniProtKB/Swiss-Prot: UD14_HUMAN, P22310

Similarity: Belongs to the UDP-glycosyltransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UGT1A4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007120

Applied Biosystems Silencer® siRNAs for UGT1A4

Sigma-Aldrich siRNA for UGT1A4

Sigma-Aldrich shRNA for UGT1A4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_007120
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007120
untagged cDNA clone in CMV expression vector: NM_007120

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007120

UniProtKB/Swiss-Prot: UD14_HUMAN, P22310

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially

toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form

both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

Induction: By phenobarbital

Enzyme Number (IUBMB): EC 2.4.1.17

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015020	glucuronosyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for UGT1A4 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Starch and Sucrose Metabolism
Xenobiotic Metabolism Signaling
Retinol Metabolism
Metabolism of Xenobiotics by Cytochrome P450
Pentose and Glucuronate Interconversions

GeneDecks UGT1A4 for the pathways selected above

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5/106 Interacting proteins for UGT1A4 (ENSP00000362513³) via UniProtKB, MINT, and/or STRING (see all 106 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP2B6	ENSP00000324648³	STRING (score=.972)
CYP2E1	ENSP00000252945³	STRING (score=.972)
GUSB	ENSP00000302728³	STRING (score=.97)
NR1I3	ENSP00000356958³	STRING (score=.969)
SLC35A2	ENSP00000247138³	STRING (score=.968)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for UGT1A4:

Inhibitor

Browse Tocris compounds for UGT1A4
10/13 Novoseek chemical compound relationships for UGT1A4 gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
n-hydroxy-n'-acetylbenzidine	89.47	1	10506112 (1)
n-acetylbenzidine	83.51	1	10506112 (1)
uridine diphosphate	83.44	3	17430308 (1), 18161889 (1), 9733664 (1)
glucuronide	80.45	4	17359941 (1), 11560872 (1), 11408353 (1)
n-hydroxy phip	76.78	3	11375903 (1), 11408353 (1)
2-naphthylamine	69.68	1	7628292 (1)
benzidine	66.62	2	12351142 (1), 7628292 (1)
phip	60.28	2	12029384 (1), 11408353 (1)
p-nitrophenol	52.05	1	12695347 (1)
amine	45.92	2	12167564 (1), 11560872 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UGT1A4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007120

Sigma-Aldrich siRNA for UGT1A4

Sigma-Aldrich shRNA for UGT1A4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_007120

REFSEQ mRNAs for UGT1A4 gene:

NM_007120.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_007120

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007120
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_007120
                                 untagged cDNA clone in CMV expression vector: NM_007120

24/271 AceView cDNA sequences (see all 271 ):

AY435143 NM_019077 AY435144 NM_019075 AK025403 BC053576 NM_000463 NM_019093

AI767337 AV660038 AY435138 AV650286 NM_001072 BE463503 AW297730 NM_019078

AV646429 CB162031 NM_007120 AI701383 NM_019076 AY435136 BE464186 AI913618

highest scoring ESTs for UGT1A4:

AA088507 AA088506 BQ327579 T61402 T73284

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A4 (see all 11 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	·	15c
SP1:							-		-		-		-		-		-		-		-		-		-		-								-
SP2:																	-		-		-		-		-		-								-
SP3:			-		-		-		-		-		-		-		-		-		-		-		-		-								-
SP4:																			-		-		-		-		-								-
SP5:																					-		-		-		-								-

About this scheme

ECgene alternative splicing isoforms for UGT1A4

14 Ensembl transcripts including schematic representations:

ENST00000344644 ENST00000373450 ENST00000373445 ENST00000354728 ENST00000373460 ENST00000373426

ENST00000305139 ENST00000360418 ENST00000373424 ENST00000406651 ENST00000373414 ENST00000318990

ENST00000373409 ENST00000305208

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UGT1A4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UGT1A4

¹ / ² / ³

11 probe-sets matching UGT1A4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32392_s_at²^{, 3}	U95-A	9	1.00	0.11	1.00	1.00	M57951	0.60	0.06	0.43	2
207126_x_at²^{, 3}	U133-A	9	1.00	0.11	--	--	NM_000463	0.20	0.04	0.14	2
204532_x_at²^{, 3}	U133-A	9	1.00	0.11	--	--	NM_021027	0.20	0.04	0.14	2
215125_s_at²^{, 3}	U133-A	9	1.00	0.11	--	--	AV691323	0.20	0.06	0.15	2
208596_s_at²^{, 3}	U133-A	9	1.00	0.11	--	--	NM_019093	0.20	0.04	0.14	2
206094_x_at²^{, 3}	U133-A	9	0.91	0.11	--	--	NM_001072	0.20	0.04	0.14	2
207126_x_at²	U133Plus2	9	1.00	0.11	--	--	--	--	--	--	--
204532_x_at²	U133Plus2	9	1.00	0.11	--	--	--	--	--	--	--
215125_s_at²	U133Plus2	9	1.00	0.11	--	--	--	--	--	--	--
208596_s_at²	U133Plus2	9	1.00	0.11	--	--	--	--	--	--	--
206094_x_at²	U133Plus2	9	0.91	0.11	--	--	--	--	--	--	--

GeneDecks UGT1A4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: UD14_HUMAN, P22310
Tissue specificity: Expressed in liver. Not expressed in skin or kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UGT1A4 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Ugt1a5¹	--	UDP glucuronosyltransferase 1 family, polypeptide A5	80.31(n) 76.98(a)	574523 NM_001039549.1 NP_001034638.1
mouse (Mus musculus)	Ugt1a5¹	--	UDP glucuronosyltransferase 1 family, polypeptide A5	78.28(n) 76.52(a)	394433 NM_201643.1 NP_964005.1
fruit fly (Drosophila melanogaster)	Ugt36Ba³	36B1	glucuronosyltransferase	30(a) (best of 8)	--
worm (Caenorhabditis elegans)	C10H11.5³	I(4724067-4726765)	--	29(a) (best of 18)	--

About this table Species with no ortholog for UGT1A4

ENSEMBL Gene Tree for UGT1A4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606429

UniProtKB/Swiss-Prot: UD14_HUMAN, P22310

The Gilbert syndrome is shown to occur as a consequence of reduced bilirubin transferase

activity. The disorder, is most often detected in young adults with vague nonspecific complaints.

A more severe inheritable deficiency in bilirubin activity exist in Crigler-Najjar (CN): patients

with type I (recessive trait) have severe hyperbilirubinemia and usually die of kernicterus

(bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life.

Patients with type II (dominant trait) have less severe hyperbilirubinemia and usually survive

into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient

glucuronyl transferase, can diminish the jaundice

2 Novoseek disease relationships for UGT1A4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
crigler-najjar syndrome	83.06	2	2108190 (1), 1920916 (1)
gilberts syndrome	59.32	2	12012638 (1), 1920916 (1)

About this table

Human Gene Mutation Database: UGT1A4
Genetic Association Database: UGT1A4
Human Genome Epidemiology Navigator: UGT1A4 (12 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/85 PubMed articles for UGT1A4 gene (see all 85 ):

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. (PubMed id 1339448)^{2, 3, 4} Ritter J.K....Owens I.S. (1992)
UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation. (PubMed id 15708967)^{1, 3, 6} Mori A....Takeuchi Y. (2005)
Identification of defect in the genes for bilirubin UDP-glucuronosyl- transferase in a patient with Crigler-Najjar syndrome type II. (PubMed id 8280139)^{1, 3, 4} Aono S.... Koiwai O. (1993)
Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. (PubMed id 1898728)^{1, 3, 4} Ritter J.K.... Owens I.S. (1991)
Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. (PubMed id 15057901)^{1, 3, 6} Ehmer U....Strassburg C.P. (2004)
Urinary excretion of phenytoin metabolites, 5-(4'-hydroxyphenyl)-5-phenylhydantoin and its O-glucuronide in humans and analysis of genetic polymorphisms of UDP-glucuronosyltransferases. (PubMed id 15855726)^{1, 3, 6} Yamanaka H....Yokoi T. (2005)
Genetic variations and haplotypes of UGT1A4 in a Japanese population. (PubMed id 15855727)^{3, 6} Saeki M....Sawada J. (2005)
Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes. (PubMed id 14871856)^{3, 6} Wiener D....Lazarus P. (2004)
Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)^{3, 4} Gong Q.H....Popescu N.C. (2001)
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PubMed id 9295054)^{2, 3} Mackenzie P.I....Nebert D.W. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54657	HGNC: 12536	AceView: UGT1A1	Ensembl:ENSG00000167165	euGenes: HUgn54657
ECgene: UGT1A4	H-InvDB: UGT1A4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for UGT1A4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UGT1A4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UGT1A4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Predesigned and custom siRNAs for UGT1A4		Antibodies for UGT1A4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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UGT1A4 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for UGT1A4

Summaries
for UGT1A4

Genomic Location
for UGT1A4

Proteins
for UGT1A4

Protein Domains/
Families
for UGT1A4

Gene Function
for UGT1A4

Pathways & Interactions
for UGT1A4

Drugs & Compounds
for UGT1A4

Transcripts
for UGT1A4

Expression
for UGT1A4

Orthologs
for UGT1A4

Paralogs
for UGT1A4

SNPs/Variants
for UGT1A4

Disorders & Mutations
for UGT1A4

Medical News
for UGT1A4

Publications
for UGT1A4

Search for UGT1A4

Genome Databases showing UGT1A4

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Licensable Technologies
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Services
for UGT1A4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UGT1A4 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor UGT1A4

Summariesfor UGT1A4

Genomic Locationfor UGT1A4

Proteinsfor UGT1A4

Protein Domains/Familiesfor UGT1A4

Gene Functionfor UGT1A4

Pathways & Interactionsfor UGT1A4

Drugs & Compoundsfor UGT1A4

Transcriptsfor UGT1A4

Expression for UGT1A4

Orthologsfor UGT1A4

Paralogsfor UGT1A4

SNPs/Variantsfor UGT1A4

Disorders & Mutationsfor UGT1A4

Medical Newsfor UGT1A4

Publicationsfor UGT1A4

Search for UGT1A4

Genome Databases showing UGT1A4

Other Databases showing UGT1A4

Specialized Databases showing UGT1A4

Licensable Technologiesfor UGT1A4

Servicesfor UGT1A4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UGT1A4

Summaries
for UGT1A4

Genomic Location
for UGT1A4

Proteins
for UGT1A4

Protein Domains/
Families
for UGT1A4

Gene Function
for UGT1A4

Pathways & Interactions
for UGT1A4

Drugs & Compounds
for UGT1A4

Transcripts
for UGT1A4

Expression
for UGT1A4

Orthologs
for UGT1A4

Paralogs
for UGT1A4

SNPs/Variants
for UGT1A4

Disorders & Mutations
for UGT1A4

Medical News
for UGT1A4

Publications
for UGT1A4

Licensable Technologies
for UGT1A4

Services
for UGT1A4