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Aliases for UGT1A3 Gene

Aliases for UGT1A3 Gene

  • UDP Glucuronosyltransferase Family 1 Member A3 2 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A3 2 3
  • UDP-Glucuronosyltransferase 1-C 3 4
  • UDP-Glucuronosyltransferase 1A3 3 4
  • EC 4 61
  • UDPGT 1-3 3 4
  • UGT1-03 3 4
  • UGT-1C 3 4
  • UGT1*3 3 4
  • UGT1.3 3 4
  • UGT1C 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A3 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A3s 3
  • UDP-Glucuronosyltransferase 1-3 3
  • UGT1A3S 3
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A3 Gene

Previous GeneCards Identifiers for UGT1A3 Gene

  • GC02U990254
  • GC02P234816
  • GC02P234879
  • GC02P234364
  • GC02P234419
  • GC02P234194
  • GC02P234204
  • GC02P234214
  • GC02P234224
  • GC02P234302
  • GC02P234637
  • GC02P226437

Summaries for UGT1A3 Gene

Entrez Gene Summary for UGT1A3 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A3 Gene

UGT1A3 (UDP Glucuronosyltransferase Family 1 Member A3) is a Protein Coding gene. Diseases associated with UGT1A3 include Gilbert Syndrome and Drug-Induced Hepatitis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A5.

UniProtKB/Swiss-Prot for UGT1A3 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A3 Gene

Genomics for UGT1A3 Gene

Regulatory Elements for UGT1A3 Gene

Enhancers for UGT1A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F233722 0.4 FANTOM5 0.4 -7.0 -6971 0.1 CTBP1 MROH2A RPL17P11 UGT1A3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UGT1A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT1A3 Gene

233,729,108 bp from pter
233,773,299 bp from pter
44,192 bases
Plus strand

Genomic View for UGT1A3 Gene

Genes around UGT1A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A3 Gene

Proteins for UGT1A3 Gene

  • Protein details for UGT1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucuronosyltransferase 1-3
    Protein Accession:
    Secondary Accessions:
    • B8K287

    Protein attributes for UGT1A3 Gene

    534 amino acids
    Molecular mass:
    60338 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A3 Gene


neXtProt entry for UGT1A3 Gene

Selected DME Specific Peptides for UGT1A3 Gene


Post-translational modifications for UGT1A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UGT1A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A3 Gene

Gene Families for UGT1A3 Gene

Protein Domains for UGT1A3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UDP-glycosyltransferase family.
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A3: view

Function for UGT1A3 Gene

Molecular function for UGT1A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A3 Gene

Gene Ontology (GO) - Molecular Function for UGT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IDA 17179145
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT1A3: view
genes like me logo Genes that share phenotypes with UGT1A3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A3 Gene

Localization for UGT1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A3 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for UGT1A3 Gene COMPARTMENTS Subcellular localization image for UGT1A3 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
peroxisome 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UGT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 17179145
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with UGT1A3: view

Pathways & Interactions for UGT1A3 Gene

genes like me logo Genes that share pathways with UGT1A3: view

Gene Ontology (GO) - Biological Process for UGT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process TAS 9295054
GO:0009813 flavonoid biosynthetic process IBA --
GO:0042573 retinoic acid metabolic process IC 20308471
GO:0052695 cellular glucuronidation IDA 17179145
GO:0052696 flavonoid glucuronidation IDA 20056724
genes like me logo Genes that share ontologies with UGT1A3: view

No data available for SIGNOR curated interactions for UGT1A3 Gene

Drugs & Compounds for UGT1A3 Gene

(57) Drugs for UGT1A3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Morphine Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate 960
atorvastatin Approved Pharma Competitive, Inhibitor, Enzyme, substrate 0
Eltrombopag Approved Pharma Enzyme, substrate 0
Cyproheptadine Approved Pharma Antagonist, Enzyme, substrate 20
Ezetimibe Approved Pharma Enzyme, substrate Cholesterol transport inhibitor 272

(89) Additional Compounds for UGT1A3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT1A3: view

Transcripts for UGT1A3 Gene

mRNA/cDNA for UGT1A3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A3 Gene

No ASD Table

Relevant External Links for UGT1A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UGT1A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT1A3 Gene

Protein differential expression in normal tissues from HIPED for UGT1A3 Gene

This gene is overexpressed in Liver (43.9) and Gallbladder (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UGT1A3 Gene

Protein tissue co-expression partners for UGT1A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT1A3 Gene:


mRNA Expression by UniProt/SwissProt for UGT1A3 Gene:

Tissue specificity: Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 1 but not isoform 2 is expressed in esophagus.
genes like me logo Genes that share expression patterns with UGT1A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UGT1A3 Gene

Orthologs for UGT1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Rattus norvegicus)
Mammalia Ugt1a2 34
  • 81.11 (n)
(Mus musculus)
Mammalia Ugt1a2 34 16 35
  • 79.61 (n)
Ugt1a5 35
  • 76 (a)
(Bos Taurus)
Mammalia -- 35
  • 70 (a)
-- 35
  • 66 (a)
-- 35
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
(Danio rerio)
Actinopterygii ugt1a7 35
  • 51 (a)
ugt1b1 35
  • 48 (a)
ugt1b2 35
  • 46 (a)
ugt1b3 35
  • 46 (a)
ugt1b4 35
  • 46 (a)
ugt1b5 35
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ugt36Bb 34
  • 44.03 (n)
Ugt37c1 36
  • 30 (a)
CG17323 36
  • 29 (a)
CG5724 36
  • 29 (a)
Ugt36Ba 36
  • 29 (a)
Ugt37a1 36
  • 29 (a)
BEST:GH06505 36
  • 28 (a)
CG10178 36
  • 26 (a)
Dot 36
  • 26 (a)
Ugt37b1 36
  • 26 (a)
CG16732 36
  • 24 (a)
CG5999 36
  • 23 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011564 34
  • 43 (n)
(Caenorhabditis elegans)
Secernentea F39G3.1 36
  • 30 (a)
AC3.2 36
  • 28 (a)
F35H8.6 36
  • 28 (a)
C08F11.8 36
  • 27 (a)
F10D2.5 36
  • 27 (a)
C10H11.5 36
  • 26 (a)
T07C5.1a 36
  • 26 (a)
ZC443.5 36
  • 26 (a)
C17G1.3 36
  • 25 (a)
C33A12.6 36
  • 25 (a)
F09G2.6 36
  • 25 (a)
K08B4.4 36
  • 25 (a)
C03A7.11 36
  • 24 (a)
C08B6.1 36
  • 24 (a)
C10H11.6 36
  • 24 (a)
C44H9.1 36
  • 24 (a)
F01D4.1 36
  • 23 (a)
F01D4.2 36
  • 23 (a)
F47C10.6 36
  • 23 (a)
R04B5.9 36
  • 23 (a)
T01G5.2 36
  • 23 (a)
Species where no ortholog for UGT1A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT1A3 Gene

Gene Tree for UGT1A3 (if available)
Gene Tree for UGT1A3 (if available)

Paralogs for UGT1A3 Gene Pseudogenes for UGT1A3 Gene

genes like me logo Genes that share paralogs with UGT1A3: view

Variants for UGT1A3 Gene

Sequence variations from dbSNP and Humsavar for UGT1A3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs887829 drug-response 233,759,924(-) TTCCA(A/G)AAATT intron-variant, upstream-variant-2KB
rs111033539 Pathogenic 233,767,160(+) TCCCT(C/T)AGACA reference, stop-gained
rs111033541 Pathogenic 233,760,331(+) GGGCC(G/T)GCTGC intron-variant, reference, missense
rs281865418 Pathogenic 233,761,127(+) AACTG(A/C/G)CTTCA intron-variant, reference, missense, stop-gained
rs28934877 Pathogenic 233,768,333(+) TGGAC(A/C/G)ATGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UGT1A3 Gene

Variant ID Type Subtype PubMed ID
dgv769e199 CNV deletion 23128226
esv2422005 CNV deletion 20811451
esv25622 CNV loss 19812545
esv2721667 CNV deletion 23290073
esv2721669 CNV deletion 23290073
esv2760613 CNV loss 21179565
esv2760615 CNV loss 21179565
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584705 CNV loss 21841781
nsv961573 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv963782 CNV duplication 23825009

Variation tolerance for UGT1A3 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT1A3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A3 Gene

Disorders for UGT1A3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UGT1A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gilbert syndrome
  • constitutional hyperbilirubinemia
drug-induced hepatitis
  • drug-induced chronic hepatitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT1A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UGT1A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A3 Gene

Publications for UGT1A3 Gene

  1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Menard V. … Guillemette C. (Hum. Mutat. 2009) 3 4 22 46 64
  2. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. (PMID: 19303655) Lankisch T.O. … Strassburg C.P. (J. Hepatol. 2009) 3 22 46 64
  3. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PMID: 18161889) Berkhout M. … Peters W.H. (Br J Surg 2008) 3 22 46 64
  4. Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene. (PMID: 18677463) Lankisch T.O. … Strassburg C.P. (Arch. Toxicol. 2008) 3 22 46 64
  5. Genetic variants of human UGT1A3: functional characterization and frequency distribution in a Chinese Han population. (PMID: 16738032) Chen Y. … Zeng S. (Drug Metab. Dispos. 2006) 3 22 46 64

Products for UGT1A3 Gene

Sources for UGT1A3 Gene

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