UGT1A3 Gene
protein-coding GIFtS: 53
GCID: GC02P234637
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UDP glucuronosyltransferase 1 family, polypeptide A3(Previous names: UDP glycosyltransferase 1 family, polypeptide A3 )
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Aliases
for UGT1A3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UDP Glucuronosyltransferase 1 Family, Polypeptide A31 2 | | UDP-Glucuronosyltransferase 1A32 3 | | UGT1C1 2 3 5 | | UDPGT 1-32 3 | | UDP Glycosyltransferase 1 Family, Polypeptide A31 2 | | EC 2.4.1.173 8 | | UGT-1C2 3 | | UDPGT2 | | UGT1*32 3 | | UDP-Glucuronosyltransferase 1-32 | | UGT1-032 3 | | GNT13 | | UGT1.32 3 | | UGT13 | | UDP-Glucuronosyltransferase 1-C2 3 | | |
Export aliases for UGT1A3 gene to outside databasesPrevious GC identifers: GC02U990254 GC02P234816 GC02P234879 GC02P234364 GC02P234419 GC02P234194 GC02P234204 GC02P234214 GC02P234224 GC02P234302 GC02P226437 |
Summaries
for UGT1A3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UGT1A3:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms smalllipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteenunique alternate first exons followed by four common exons. Four of the alternate first exons are consideredpseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteinswith different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulatedby its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzoalpha-pyrene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UD13_HUMAN, P35503Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobioticsand endogenous compounds
Gene Wiki entry for UGT1A3
|
Genomic Views
for UGT1A3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UGT1A3 gene promoter:
STAT5B STAT1 STAT4 STAT6 STAT1beta STAT5A STAT1alpha PPAR-alpha STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for UGT1A3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37UGT1A3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P234637: view genomic region
(about GC identifiers)
Start:
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234,637,754 bp from pter |
End:
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234,681,945 bp from pter |
Size:
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44,192 bases |
Orientation:
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plus strand |
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Proteins
for UGT1A3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UD13_HUMAN, P35503 (See
protein sequence)Recommended Name: UDP-glucuronosyltransferase 1-3 precursor Size: 534 amino acids; 60338 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)Alternative splicing: 1 isoform: P35503-1 Explore the universe of human proteins at neXtProt for UGT1A3: NX_P35503
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P35503
4/21 DME Specific Peptides for UGT1A3 (P35503) (see all 21)
UGT1A3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061966.1
ENSEMBL proteins: ENSP00000418532 Reactome Protein details: P35503
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UGT1A3 for ontologies About GeneDecksing
UGT1A3 Antibody Products:
Assay Products for UGT1A3: |
Protein
Domains /
Families
for UGT1A3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UGT1A3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P35503ProtoNet protein and cluster: P35503 1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase
UniProtKB/Swiss-Prot: UD13_HUMAN, P35503Similarity: Belongs to the UDP-glycosyltransferase family |
Function
for UGT1A3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UD13_HUMAN, P35503Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobioticsand endogenous compoundsCatalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronosideEnzyme Number (IUBMB): EC 2.4.1.171 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A3
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A3 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
UGT1A3 for ontologies About GeneDecksing
|
Pathways & Interactions
for UGT1A3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Glucuronidation | | | 2 | Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics | | | 3 | Drug metabolism - cytochrome P450 | | | 4 | Biological oxidations | | | 5 | Retinol metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for UGT1A3
3  GeneGo (Thomson Reuters) Pathways for UGT1A3
4  BioSystems Pathways for UGT1A3
4 
Reactome Pathways for UGT1A3
5/7  PharmGKB Pathways for UGT1A3 (see all 7)
5/11 
Kegg Pathways (Kegg details for UGT1A3) (see all 11):
UGT1A3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT1A3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/56 Interacting proteins for UGT1A3 (ENSP000004185324) via UniProtKB, MINT, STRING, and/or I2D (see all 56)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
UGT1A3 for ontologies About GeneDecksing
|
Drugs & Compounds
for UGT1A3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UGT1A3 for compounds About GeneDecksing
 Browse Tocris compounds for UGT1A3
10/84 HMDB Compounds for UGT1A3 (see all 84) About this table
10/12 DrugBank Compounds for UGT1A3 (see all 12) About this table
10/18 Novoseek chemical compound relationships for UGT1A3 gene (see all 18) About this table
Search CenterWatch for drugs/clinical trials and news about UGT1A3 / UD13
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Transcripts
for UGT1A3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UGT1A3 gene: NM_019093.2 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000482026(uc010znb.1 uc002vuy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UGT1A3 (NM_019093) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UGT1A3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A3 |
24/271 AceView cDNA sequences (see all 271): AI566081 NM_007120 CB157019 CB163341 AI795931 BI764371 NM_019093 NM_019076 CB162031 BG165230 AI478649 BE464422 NM_001072 AY435138 NM_021027 AU076863 NM_205862 AK025403 AY435141 AI913618 CB163625 BM829535 AY435139 NM_019075
GeneLoc Exon Structure
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Expression
for UGT1A3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UGT1A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See UGT1A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UGT1A3
SABiosciences Custom PCR Arrays for UGT1A3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT1A3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat UGT1A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGT1A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT1A3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A3 |
Orthologs
for UGT1A3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for UGT1A3 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for UGT1A3 (if available)
TreeFam Gene Tree for UGT1A3 (if available) |
Paralogs
for UGT1A3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UGT1A3 gene
- UGT2A22 UGT1A82 UGT1A72 UGT3A12 UGT2B72 UGT2B112 UGT1A12 UGT1A52
- UGT3A22 UGT2B102 UGT1A102 UGT1A62 UGT82 UGT2B152 UGT2B42 UGT2B172
- UGT2A32 UGT2B282 UGT1A92 UGT1A42
18/30 SIMAP similar genes for UGT1A3 using alignment to 18 protein entries: UD13_HUMAN (see all proteins)
(see all similar genes):UGT1A3S UGT1A5 UGT1A4 UGT1A4S UGT1A9S UGT1
BILIQTL1 UGT1A1 UGT1A8S UGT1A6 UGT1A6S UGT1A9
UGT1A8 UGT1A10 UGT1H UGT1J UGT1A7 UGT1G
UGT1A3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UGT1A3
PGOHUM00000241148
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Genomic Variants
for UGT1A3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for UGT1A3
8 CNVs: 90342 90341 61892 35795 50416 37520 63332 90340
Human Gene Mutation Database (HGMD): UGT1A3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT1A3 |
|
Disorders
/ Diseases
for UGT1A3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UGT1A3 for disorders About GeneDecksing
OMIM gene information: 606428
OMIM disorders: --
14  diseases for UGT1A3: About MalaCardsdrug-induced hepatitis familial adenomatous polyposis neonatal jaundice gilbert syndrome
kernicterus hearing loss polyposis jaundice
cholestasis duodenitis lung cancer hepatitis
cholesterol schizophrenia
1 disease from the University of Copenhagen DISEASES database for UGT1A3:Bilirubin metabolic disorder Genetic Association Database (GAD): UGT1A3
Human Genome Epidemiology (HuGE) Navigator: UGT1A3 (19 documents)
Export disorders for UGT1A3 gene to outside databases
|
Publications
for UGT1A3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UGT1A3 gene, integrated from 9 sources (see all 106):
(articles sorted by number of sources associating them with UGT1A3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)1, 2, 3 Gong Q.H....Popescu N.C. (2001)
- A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. (PubMed id 1339448)1, 2, 3 Ritter J.K....Owens I.S. (1992)
- Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)1, 2, 9 MAcnard V....Guillemette C. (2009)
- Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity. (PubMed id 14986168)1, 4, 9 Iwai M....Takeuchi Y. (2004)
- Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. (PubMed id 15057901)1, 4, 9 Ehmer U....Strassburg C.P. (2004)
- Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. (PubMed id 9616184)1, 7, 9 Green M.D....Tephly T.R. (1998)
- N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases. (PubMed id 14570768)1, 6 Kuehl G.E. and Murphy S.E. (2003)
- The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PubMed id 9295054)1, 3 Mackenzie P.I....Nebert D.W. (1997)
- Regulation of the human bile acid UDP-glucuronosyltra nsferase 1A3 by the farnesoid X receptor and bile acids. (PubMed id 20189675)1, 9 Erichsen T.J....Strassburg C.P. (2010)
- Genetic variants of human UGT1A3: functional characterization and frequency distribution in a Chinese Han population. (PubMed id 16738032)1, 9 Chen Y....Zeng S. (2006)
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External Searches for UGT1A3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UGT1A3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UGT1A3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UGT1A3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UGT1A3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UGT1A3 gene:
Search GeneIP for patents involving UGT1A3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UGT1A3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | UGT1A3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A3 |
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