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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT1A3 Gene

protein-coding   GIFtS: 54
GCID: GC02P234637

UDP Glucuronosyltransferase 1 Family, Polypeptide A3

(Previous names: UDP glycosyltransferase 1 family, polypeptide A3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A31 2     UDP-Glucuronosyltransferase 1A32 3
UGT1C2 3 5     UDPGT 1-32 3
UDP Glycosyltransferase 1 Family, Polypeptide A31 2     EC 2.4.1.173 8
UGT-1C2 3     UDPGT2
UGT1*32 3     UDP-Glucuronosyltransferase 1-32
UGT1-032 3     GNT13
UGT1.32 3     UGT13
UDP-Glucuronosyltransferase 1-C2 3     

External Ids:    HGNC: 125351   Entrez Gene: 546592   Ensembl: ENSG000002431357   OMIM: 6064285   UniProtKB: P355033   

Export aliases for UGT1A3 gene to outside databases

Previous GC identifers: GC02U990254 GC02P234816 GC02P234879 GC02P234364 GC02P234419 GC02P234194 GC02P234204 GC02P234214 GC02P234224 GC02P234302 GC02P226437


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGT1A3 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone,
2-hydroxyestrone, and metabolites of benzo alpha-pyrene. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A3 Gene: 
UGT1A3 (UDP glucuronosyltransferase 1 family, polypeptide A3) is a protein-coding gene. Diseases associated with UGT1A3 include drug-induced hepatitis, and kernicterus, and among its related super-pathways are Ascorbate and aldarate metabolism and Phase II conjugation. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD13_HUMAN, P35503
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds

Gene Wiki entry for UGT1A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT1A3 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   PPAR-alpha   STAT2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234637:  view genomic region     (about GC identifiers)

Start:
234,637,754 bp from pter      End:
234,681,945 bp from pter
Size:
44,192 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UD13_HUMAN, P35503 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-3 precursor  
Size: 534 amino acids; 60338 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Alternative splicing: 1 isoform:  P35503-1   

Explore the universe of human proteins at neXtProt for UGT1A3: NX_P35503

Explore proteomics data for UGT1A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35503

  • 4/21 DME Specific Peptides for UGT1A3 (P35503) (see all 21)
     FWVEFVM  QYHSLDV  DVIGFLL  GSHWLSM 

    UGT1A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGT1A3 Protein Expression
    REFSEQ proteins: NP_061966.1  
    ENSEMBL proteins: 
     ENSP00000418532  
    Reactome Protein details: P35503
    Human Recombinant Protein Products for UGT1A3: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    UGT1A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry P35503

    ProtoNet protein and cluster: P35503

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD13_HUMAN, P35503
    Similarity: Belongs to the UDP-glycosyltransferase family


    UGT1A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD13_HUMAN, P35503
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA--
    GO:0008194UDP-glycosyltransferase activity TAS9295054
    GO:0015020glucuronosyltransferase activity IDA18052087
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0019899enzyme binding IDA--
         
    UGT1A3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UGT1A3 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.67
    Starch and sucrose metabolism0.41
    Glucuronidation0.67
    Porphyrin and chlorophyll metabolism0.38
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.33
    Pentose and glucuronate interconversions0.61
    Steroid hormone biosynthesis0.30
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Estrogen metabolism
    Estrogen metabolism0.43
    Estrogen Metabolism Pathway0.43
    4Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    5Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics0.80
    Statin Pathway - Generalized, Pharmacokinetics0.70
    Fluvastatin Pathway, Pharmacokinetics0.80
    Ibuprofen Pathway, Pharmacokinetics0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for UGT1A3
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Retinol metabolism
    Acetaminophen metabolism


    3 GeneGo (Thomson Reuters) Pathways for UGT1A3
        Retinol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Acetaminophen metabolism

    4 BioSystems Pathways for UGT1A3
        Glucuronidation
    Estrogen metabolism
    thyroid hormone metabolism II (via conjugation and/or degradation)
    metapathway biotransformation


    4        Reactome Pathways for UGT1A3
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation

    5/8 PharmGKB Pathways for UGT1A3 (see all 8)
        Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Fluvastatin Pathway, Pharmacokinetics
    Ibuprofen Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacodynamics

    5/11         Kegg Pathways  (Kegg details for UGT1A3) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism


    UGT1A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT1A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT1A3 (ENSP000004185324) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    CES2ENSP000003178424STRING: ENSP00000317842
    COMTENSP000003545114STRING: ENSP00000354511
    CYP19A1ENSP000002604334STRING: ENSP00000260433
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0008152metabolic process TAS9295054
    GO:0030259lipid glycosylation ----
    GO:0042573retinoic acid metabolic process IC--
    GO:0052696flavonoid glucuronidation IDA--

    UGT1A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT1A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT1A3 (UD13)

    10/84 HMDB Compounds for UGT1A3 (see all 84)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-715843492
    Ethyl glucuronide 17685-04-016139098
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-315843492
    Nicotine glucuronide(S)-1-alpha-D-glucopyranuronosyl-3-(1-methyl-2-pyrrolidinyl)-Pyridinium inner salt (see all 11)152306-59-714570768
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----

    10/21 DrugBank Compounds for UGT1A3 (see all 21)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Valproic Acid2-Propylpentanoic Acid (see all 8)99-66-1enzymesubstrate15761113 17687269 18838507
    Ezetimibe-- 163222-33-1enzymesubstrate15871634 21368751
    Atorvastatin-- 134523-00-5enzymesubstrate23580084
    Candesartan-- 139481-59-7enzymesubstrate19515014
    Cyproheptadine-- 129-03-3enzymesubstrate9616184
    Etodolac-- 41340-25-4enzymesubstrate19515014
    Ezogabine D-23129 (see all 5)150812-12-7enzymesubstrate10220490
    Flunitrazepam-- 1622-62-4enzymeinhibitor9848110
    FlurbiprofenFLP (see all 5)5104-49-4enzymesubstrate19515014
    IbuprofenIbuprophen (see all 3)15687-27-1enzymesubstrate19515014

    10/18 Novoseek inferred chemical compound relationships for UGT1A3 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucuronide 78.2 4 17359941 (1), 9733664 (1), 11560872 (1)
    uridine diphosphate 76.8 2 18161889 (1), 9733664 (1)
    2-hydroxyestrone 69 1 8780690 (1)
    estrone 56.2 1 8780690 (1)
    buprenorphine 53.6 5 9848110 (2), 19841060 (2)
    diclofenac 52.2 3 17359941 (1), 15334623 (1), 15988124 (1)
    p-nitrophenol 50.3 1 12695347 (1)
    indinavir 50.2 2 19303655 (1), 16609363 (1)
    imipramine 48.5 2 12695347 (1), 12019188 (1)
    flunitrazepam 47.8 3 9848110 (1), 15334623 (1)

    Search CenterWatch for drugs/clinical trials and news about UGT1A3 / UD13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGT1A3 gene: 
    NM_019093.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000482026(uc010znb.1 uc002vuy.3)
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    24/271 AceView cDNA sequences (see all 271):

    NM_021027 AV660038 NM_019076 NM_007120 AI479279 BI764371 CB157019 AI767337 
    AY435137 BE463503 NM_019093 AY435144 BM829535 AI913618 AY435140 BE464422 
    NM_019078 AY435139 AI566081 CB162031 AW297730 BE464186 AK025403 NM_000463 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT1A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A3 Expression
    About this image


    See UGT1A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT1A3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A3 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a21 , 5 UDP glucuronosyltransferase 1 family, polypeptide A21, 5 79.55(n)1
    75.8(a)1
      1 (44.54 cM)5
    222361  NM_013701.31  NP_038729.11 
     882006015 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    1(118864159-118904238)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1ab6
    ugt1b46
    UDP glucuronosyltransferase 1 family a, b
    UDP glucuronosyltransferase 1 family, polypeptide ...
    51(a)
    45(a)
    many ↔ many
    many ↔ many
    9(10194767-10228512)
    11(31171792-31204741)


    ENSEMBL Gene Tree for UGT1A3 (if available)
    TreeFam Gene Tree for UGT1A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT1A3 gene
    UGT2A22  UGT1A82  UGT3A12  UGT1A72  UGT2B112  UGT2B72  UGT1A12  UGT3A22  
    UGT1A52  UGT2B102  UGT2A12  UGT1A102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2A32  UGT2B172  UGT2B282  UGT1A92  UGT1A42  
    18/30 SIMAP similar genes for UGT1A3 using alignment to 18 protein entries:     UD13_HUMAN (see all proteins) (see all similar genes):
    UGT1A3S    UGT1A5    UGT1A4    UGT1A4S    UGT1A9S    UGT1
    BILIQTL1    UGT1A1    UGT1A8S    UGT1A6    UGT1A6S    UGT1A9
    UGT1A8    UGT1A10    UGT1H    UGT1J    UGT1A7    UGT1G

    UGT1A3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UGT1A3
    PGOHUM00000241148


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10 SNPs in UGT1A3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0524484
    ----see VAR_0524482 V A mis40--------
    VAR_0585834
    ----see VAR_0585832 A V mis40--------
    VAR_0524534
    ----see VAR_0524532 M V mis40--------
    VAR_0524504
    ----see VAR_0524502 T I mis40--------
    VAR_0524494
    ----see VAR_0524492 R W mis40--------
    VAR_0524474
    ----see VAR_0524472 R W mis40--------
    VAR_0524524
    ----see VAR_0524522 T I mis40--------
    VAR_0524454
    ----see VAR_0524452 Q R mis40--------
    VAR_0524464
    ----see VAR_0524462 W R mis40--------
    VAR_0524514
    ----see VAR_0524512 M I mis40--------

    HapMap Linkage Disequilibrium report for UGT1A3 (234637754 - 234681945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for UGT1A3 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2721669CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721667CNV Deletion23290073
    nsv498958CNV Loss21111241
    esv8142CNV Loss19470904
    nsv519815CNV Loss19592680
    nsv3215CNV Loss18451855
    esv25622CNV Loss19812545
    nsv433211CNV Loss18776910


    Human Gene Mutation Database (HGMD): UGT1A3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT1A3
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606428    OMIM disorders: --

    17 diseases for UGT1A3:    About MalaCards
    drug-induced hepatitis    kernicterus    gilbert syndrome    neonatal jaundice
    jaundice    cholelithiasis    sickle cell anemia    familial adenomatous polyposis
    duodenitis    cholestasis    cytochrome p450    metabolic disorders
    schizophrenia    hepatitis    lung cancer    anemia
    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for UGT1A3:
    Bilirubin metabolic disorder

    UGT1A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UGT1A3
    Human Genome Epidemiology (HuGE) Navigator: UGT1A3 (19 documents)

    Export disorders for UGT1A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT1A3 gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with UGT1A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PubMed id 19204906)1, 2, 4, 9 MAcnard V....Guillemette C. (2009)
    2. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)1, 2, 3 Gong Q.H....Popescu N.C. (2001)
    3. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. (PubMed id 1339448)1, 2, 3 Ritter J.K....Owens I.S. (1992)
    4. Genetic variants of human UGT1A3: functional characterization and frequency distribution in a Chinese Han population. (PubMed id 16738032)1, 4, 9 Chen Y....Zeng S. (2006)
    5. Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene. (PubMed id 18677463)1, 4, 9 Lankisch T.O....Strassburg C.P. (2008)
    6. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PubMed id 18161889)1, 4, 9 Berkhout M....Peters W.H. (2008)
    7. Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity. (PubMed id 14986168)1, 4, 9 Iwai M....Takeuchi Y. (2004)
    8. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. (PubMed id 15057901)1, 4, 9 Ehmer U....Strassburg C.P. (2004)
    9. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. (PubMed id 9616184)1, 7, 9 Green M.D....Tephly T.R. (1998)
    10. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. (PubMed id 19303655)1, 4, 9 Lankisch T.O....Strassburg C.P. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54659 HGNC: 12535 AceView: UGT1A1 Ensembl:ENSG00000243135 euGenes: HUgn54659
    ECgene: UGT1A3 Kegg: 54659 H-InvDB: UGT1A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT1A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGT1A3 gene:
    Search GeneIP for patents involving UGT1A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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