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UGT1A10 Gene

protein-coding   GIFtS: 53
GCID: GC02P234545

UDP Glucuronosyltransferase 1 Family, Polypeptide A10

(Previous names: UDP glycosyltransferase 1 family, polypeptide A10)
  See UGT1A10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A101 2     UDPGT 1-102 3
UDP Glycosyltransferase 1 Family, Polypeptide A101 2     EC 2.4.1.173 8
UGT-1J2 3     UDPGT2
UGT1-102 3     UDP-Glucuronosyltransferase 1-102
UGT1.102 3     GNT13
UGT1J2 3     UGT13
UDP-Glucuronosyltransferase 1-J2 3     UGT1*103
UDP-Glucuronosyltransferase 1A102 3     

External Ids:    HGNC: 125311   Entrez Gene: 545752   Ensembl: ENSG000002425157   OMIM: 6064355   UniProtKB: Q9HAW83   

Export aliases for UGT1A10 gene to outside databases

Previous GC identifers: GC02U990246 GC02P234814 GC02P234877 GC02P234327 GC02P234192 GC02P234202 GC02P234211 GC02P234222 GC02P234226 GC02P226345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UGT1A10 Gene:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable
metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus
includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons
are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons,
resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the
substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase
activity on mycophenolic acid, coumarins, and quinolines. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A10 Gene:
UGT1A10 (UDP glucuronosyltransferase 1 family, polypeptide A10) is a protein-coding gene. Diseases associated with UGT1A10 include bilirubin metabolic disorder, and sickle cell anemia. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot: UD110_HUMAN, Q9HAW8
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
xenobiotics and endogenous compounds

Gene Wiki entry for UGT1A10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the UGT1A10 gene promoter:
         TBP   SRF   TFIID   SRF (504 AA)   c-Myb   LCR-F1   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UGT1A10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT1A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234545:  view genomic region     (about GC identifiers)

Start:
234,545,100 bp from pter      End:
234,681,951 bp from pter
Size:
136,852 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UD110_HUMAN, Q9HAW8 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-10 precursor  
Size: 530 amino acids; 59810 Da
Secondary accessions: O00474 Q6NT91
Alternative splicing: 1 isoform:  Q9HAW8-1   

Explore the universe of human proteins at neXtProt for UGT1A10: NX_Q9HAW8

Explore proteomics data for UGT1A10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn292, Asn344
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGT1A10 (Q9HAW8) (see all 24)
     PEVSWQL  FWVEFVM  WLLRTDF  QYHSLDV 


    See UGT1A10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061948.1  
    ENSEMBL proteins: 
     ENSP00000343838   ENSP00000362544  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UGT: UDP glucuronosyltransferases

    1 InterPro protein domain:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q9HAW8

    ProtoNet protein and cluster: Q9HAW8

    1 Blocks protein domain: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD110_HUMAN, Q9HAW8
    Similarity: Belongs to the UDP-glycosyltransferase family


    Find genes that share domains with UGT1A10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD110_HUMAN, Q9HAW8
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic
    xenobiotics and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972NOT retinoic acid binding IDA--
    GO:0005080protein kinase C binding IPI18556656
    GO:0015020glucuronosyltransferase activity IDA18052087
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0019899enzyme binding IDA--
         
    Find genes that share ontologies with UGT1A10           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGT1A10
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UD110_HUMAN, Q9HAW8: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    extracellular2
    nucleus2
    peroxisome2
    golgi apparatus1
    lysosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18556656
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UGT1A10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGT1A10 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Glucuronidation0.00
    Phase II conjugation0.56
    Tamoxifen metabolism0.00
    metapathway biotransformation0.42
    Estradiol metabolism0.00
    Tamoxifen Pathway, Pharmacokinetics0.00
    Acetaminophen metabolism0.00
    2Glucuronidation
    Glucuronidation0.61
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    Drug metabolism - other enzymes0.36
    Pentose and glucuronate interconversions0.61
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Metabolism of xenobiotics by cytochrome P4500.71
    Benzo a pyrene metabolism0.00
    Drug metabolism - cytochrome P4500.69
    4Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    5Metabolism of porphyrins
    Metabolism of porphyrins0.56
    Heme degradation0.00
    Porphyrin and chlorophyll metabolism0.56


    Find genes that share SuperPaths with UGT1A10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for UGT1A10
        Estradiol metabolism
    Benzo[a]pyrene metabolism
    Acetaminophen metabolism

    Selected BioSystems Pathways for UGT1A10 (see all 12)
        Glucuronidation
    Irinotecan Pathway
    nicotine degradation IV
    nicotine degradation III
    Tamoxifen metabolism


    Selected PharmGKB Pathways for UGT1A10 (see all 6)
        Ibuprofen Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacodynamics
    Irinotecan Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics
    Tamoxifen Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for UGT1A10) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Retinol metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UGT1A10
    Interactions:

        Search GeneGlobe Interaction Network for UGT1A10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGT1A10 (ENSP000003438384) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH6ENSP000003783594STRING: ENSP00000378359
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    BLVRAENSP000002655234STRING: ENSP00000265523
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0008152metabolic process ----
    GO:0030259lipid glycosylation ----
    GO:0051552flavone metabolic process IDA18052087
    GO:0052695cellular glucuronidation IDA--

    Find genes that share ontologies with UGT1A10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGT1A10 (UD110)

    Selected HMDB Compounds for UGT1A10 (see all 84)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ethyl glucuronide 17685-04-016139098
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----

    6 DrugBank Compounds for UGT1A10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate15781124
    Etodolac-- 41340-25-4enzymesubstrate19515014
    LosartanDuP 89 (see all 2)114798-26-4enzymesubstrate19515014
    Mycophenolate mofetilMMF (see all 4)128794-94-5enzymesubstrate11817210
    Troglitazone-- 97322-87-7enzymesubstrate12433820
    Valproic Acid2-Propylpentanoic Acid (see all 8)99-66-1enzymesubstrate15761113

    Selected Novoseek inferred chemical compound relationships for UGT1A10 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udp glucuronic acid 78.7 1 18048489 (1)
    uridine diphosphate 77.2 1 18161889 (1)
    n-hydroxy phip 76.2 2 11375903 (1)
    glucuronide 63.8 1 11560872 (1)
    imipramine 49.1 1 12019188 (1)
    mycophenolic acid 42.6 4 9325166 (3), 15039300 (1)
    orthophosphate 41.2 2 15845768 (1), 15117964 (1)
    cotinine 34.8 2 12433823 (1), 12167564 (1)
    propofol 34 1 12386132 (1)
    curcumin 32.3 1 15845768 (1)

    1 PharmGKB related drug/compound annotation for UGT1A10 gene    About this table
    Drug/compound PharmGKB Annotation
    valproic acidCA  



    Find genes that share compounds with UGT1A10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UGT1A10 gene: 
    NM_019075.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344644(uc002vur.3) ENST00000373445
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat UGT1A10
      QuantiFast Probe-based Assays in human, mouse, rat UGT1A10

    Selected AceView cDNA sequences (see all 271):

    AK025403 AY435144 AY435140 AV660038 NM_000463 BE463503 NM_205862 BC053576 
    BE464379 AY435143 AY435136 NM_019077 AI479279 AI701383 AI795931 AI767337 
    NM_001072 NM_007120 NM_021027 CB163625 NM_019076 AV650286 AY435141 AI478649 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UGT1A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UGT1A10 Expression
    About this image

    UGT1A10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGT1A10 Protein Expression

    UniProtKB/Swiss-Prot: UD110_HUMAN, Q9HAW8
    Tissue specificity: Liver and colon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A10 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugt1a91 UDP glucuronosyltransferase 1 family, polypeptide A9 80.4(n)
    79.31(a)
      394434  NM_201644.2  NP_964006.2 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    59(a)
    42(a)
    many ↔ many
    many ↔ many
    7(5735050-5897491)
    7(5872756-5873724)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    many ↔ many
    6(58560593-58594758)
    zebrafish
    (Danio rerio)
    Actinopterygii ugt1a76
    ugt1b46
    (see all 6)
    UDP glucuronosyltransferase 1 family, polypeptide ...
    UDP glucuronosyltransferase 1 family, polypeptide ...
    (see all 6)
    49(a)
    46(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    9(10194767-10228491) ENSDARG00000006220
    11(31182060-31204509) ENSDARG00000097024


    ENSEMBL Gene Tree for UGT1A10 (if available)
    TreeFam Gene Tree for UGT1A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGT1A10 gene
    UGT1A81 2  UGT1A71 2  UGT1A91 2  UGT2A22  UGT3A12  UGT2B112  UGT2B72  UGT1A32  
    UGT1A12  UGT3A22  UGT1A52  UGT2B102  UGT2A12  UGT1A62  UGT82  UGT2B152  
    UGT2B42  UGT2A32  UGT2B172  UGT2B282  UGT1A42  
    Selected SIMAP similar genes for UGT1A10 using alignment to 3 protein entries:     UD110_HUMAN (see all proteins) (see all similar genes):
    UGT1J    UGT1A9S    UGT1A8S    UGT1A8    UGT1A9    UGT1A3S
    UGT1H    UGT1A7    UGT1G    UGT1A6    BILIQTL1    UGT1A6S
    UGT1A1    UGT1A4S    UGT2A3    UGT1A4    UGT2B7    UGT1A5

    Find genes that share paralogs with UGT1A10           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UGT1A10
    PGOHUM00000259940


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for UGT1A10    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289696851,2,4
    ----see VAR_0524652 mis40--------
    rs569358331,2,4
    ----see VAR_0183542 mis40--------
    rs587044321,2,4
    ----see VAR_0183552 mis40--------
    rs101876941,2,4
    ----see VAR_0524642 mis40--------

    HapMap Linkage Disequilibrium report for UGT1A10 (234545100 - 234681951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGT1A10 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2661542CNV Deletion23128226
    esv2721664CNV Deletion23290073
    esv2721667CNV Deletion23290073
    esv2721666CNV Deletion23290073
    esv2721663CNV Deletion23290073
    esv2721669CNV Deletion23290073
    esv2422005CNV Deletion20811451
    esv2721668CNV Deletion23290073
    nsv514125CNV Loss21397061

    Human Gene Mutation Database (HGMD): UGT1A10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGT1A10
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606435    OMIM disorders: --

    3 diseases for UGT1A10:    
    About MalaCards
    bilirubin metabolic disorder    sickle cell anemia    kernicterus

    2 diseases from the University of Copenhagen DISEASES database for UGT1A10:
    Bilirubin metabolic disorder     Kernicterus

    Find genes that share disorders with UGT1A10           About GenesLikeMe

    2 Novoseek inferred disease relationships for UGT1A10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 24.2 1 16620709 (1)
    cancer 0 10 16510539 (3), 20007297 (1)

    Genetic Association Database (GAD): UGT1A10
    Human Genome Epidemiology (HuGE) Navigator: UGT1A10 (15 documents)

    Export disorders for UGT1A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGT1A10 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with UGT1A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility. (PubMed id 20007297)1, 4, 9 Balliet R.M....Lazarus P. (Drug Metab. Dispos. 2010)
    2. Three novel single nucleotide polymorphisms in UGT1A10. (PubMed id 15618702)1, 2, 9 Saeki M.... Sawada J. (Drug Metab. Pharmacokinet. 2002)
    3. The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid. (PubMed id 9325166)1, 3, 9 Mojarrabi B. and Mackenzie P.I. (Biochem. Biophys. Res. Commun. 1997)
    4. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. (PubMed id 15057901)1, 4, 9 Ehmer U....Strassburg C.P. (Hepatology 2004)
    5. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PubMed id 18161889)1, 4, 9 Berkhout M....Peters W.H. (Br J Surg 2008)
    6. A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study. (PubMed id 22511988)1, 4 JylhAovAo J....Hurme M. (PLoS ONE 2012)
    7. UGT1A1 is a major locus influencing bilirubin levels in African Americans. (PubMed id 22085899)1, 4 Chen G....Rotimi C.N. (Eur. J. Hum. Genet. 2012)
    8. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. (PubMed id 22558097)1, 4 Milton J.N....Klings E.S. (PLoS ONE 2012)
    9. Human metabolic individuality in biomedical and pharmaceutical research. (PubMed id 21886157)1, 4 Suhre K....Gieger C. (Nature 2011)
    10. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PubMed id 21646302)1, 4 Bielinski S.J....Chute C.G. (Mayo Clin. Proc. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54575 HGNC: 12531 AceView: UGT1A1 Ensembl:ENSG00000242515 euGenes: HUgn54575
    ECgene: UGT1A10 Kegg: 54575 H-InvDB: UGT1A10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UGT1A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UGT1A10 gene:
    Search GeneIP for patents involving UGT1A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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