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Aliases for UGT1A10 Gene

Aliases for UGT1A10 Gene

  • UDP Glucuronosyltransferase Family 1 Member A10 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A10 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A10 2 3
  • UDP-Glucuronosyltransferase 1A10 3 4
  • UDP-Glucuronosyltransferase 1-J 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 1-10 3 4
  • UGT1-10 3 4
  • UGT1.10 3 4
  • UGT-1J 3 4
  • UGT1J 3 4
  • UGT1*10 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A10 Gene

Previous GeneCards Identifiers for UGT1A10 Gene

  • GC02U990246
  • GC02P234814
  • GC02P234877
  • GC02P234327
  • GC02P234192
  • GC02P234202
  • GC02P234211
  • GC02P234222
  • GC02P234226
  • GC02P234545
  • GC02P226345

Summaries for UGT1A10 Gene

Entrez Gene Summary for UGT1A10 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A10 Gene

UGT1A10 (UDP Glucuronosyltransferase Family 1 Member A10) is a Protein Coding gene. Diseases associated with UGT1A10 include pericholangitis and cholelithiasis. Among its related pathways are Metabolism and Irinotecan Pathway, Pharmacokinetics. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT1A10 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A10 Gene

Genomics for UGT1A10 Gene

Regulatory Elements for UGT1A10 Gene

Genomic Location for UGT1A10 Gene

Chromosome:
2
Start:
233,636,454 bp from pter
End:
233,773,305 bp from pter
Size:
136,852 bases
Orientation:
Plus strand

Genomic View for UGT1A10 Gene

Genes around UGT1A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A10 Gene

Proteins for UGT1A10 Gene

  • Protein details for UGT1A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAW8-UD110_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-10
    Protein Accession:
    Q9HAW8
    Secondary Accessions:
    • O00474
    • Q6NT91
    • Q7Z6H8

    Protein attributes for UGT1A10 Gene

    Size:
    530 amino acids
    Molecular mass:
    59810 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A10 Gene

Proteomics data for UGT1A10 Gene at MOPED

Post-translational modifications for UGT1A10 Gene

  • Glycosylation at Asn 71, Asn 292, and Asn 344
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT1A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UGT1A10 (UGT1A10)

Domains & Families for UGT1A10 Gene

Gene Families for UGT1A10 Gene

Protein Domains for UGT1A10 Gene

Suggested Antigen Peptide Sequences for UGT1A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAW8

UniProtKB/Swiss-Prot:

UD110_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A10: view

Function for UGT1A10 Gene

Molecular function for UGT1A10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A10 Gene

Gene Ontology (GO) - Molecular Function for UGT1A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0016758 transferase activity, transferring hexosyl groups IEA --
GO:0042803 protein homodimerization activity IDA 17179145
genes like me logo Genes that share ontologies with UGT1A10: view
genes like me logo Genes that share phenotypes with UGT1A10: view

Animal Model Products

CRISPR Products

miRNA for UGT1A10 Gene

miRTarBase miRNAs that target UGT1A10

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT1A10 Gene

Localization for UGT1A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A10 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A10 Gene COMPARTMENTS Subcellular localization image for UGT1A10 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for UGT1A10 Gene

Pathways & Interactions for UGT1A10 Gene

genes like me logo Genes that share pathways with UGT1A10: view

Interacting Proteins for UGT1A10 Gene

Gene Ontology (GO) - Biological Process for UGT1A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0051552 flavone metabolic process IDA 18052087
GO:0052696 flavonoid glucuronidation IBA --
GO:1904224 negative regulation of glucuronosyltransferase activity ISS 20610558
genes like me logo Genes that share ontologies with UGT1A10: view

No data available for SIGNOR curated interactions for UGT1A10 Gene

Drugs & Compounds for UGT1A10 Gene

(28) Drugs for UGT1A10 Gene - From: HMDB, DrugBank, Novoseek, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Valproic Acid Approved, Investigational Pharma Enzyme, substrate HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 311
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 898
Acetaminophen Approved Pharma Enzyme, substrate 864
Etodolac Approved, Investigational Pharma Enzyme, substrate COX-2 inhibitor 20
Losartan Approved Pharma Antagonist, Enzyme, substrate 276

(88) Additional Compounds for UGT1A10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT1A10: view

Transcripts for UGT1A10 Gene

mRNA/cDNA for UGT1A10 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A10 Gene

No ASD Table

Relevant External Links for UGT1A10 Gene

GeneLoc Exon Structure for
UGT1A10
ECgene alternative splicing isoforms for
UGT1A10

Expression for UGT1A10 Gene

mRNA expression in normal human tissues for UGT1A10 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A10 Gene

This gene is overexpressed in Colon - Transverse (x29.8), Small Intestine - Terminal Ileum (x11.1), and Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for UGT1A10 Gene

This gene is overexpressed in Stomach (54.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UGT1A10 Gene



mRNA Expression by UniProt/SwissProt for UGT1A10 Gene

Q9HAW8-UD110_HUMAN
Tissue specificity: Liver and colon. Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212).
genes like me logo Genes that share expression patterns with UGT1A10: view

Protein tissue co-expression partners for UGT1A10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UGT1A10 Gene

Orthologs for UGT1A10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UGT1A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT1A10 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 67 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ugt1a10 36
  • 78 (a)
ManyToMany
Ugt1a7c 36
  • 78 (a)
ManyToMany
Ugt1a8 36
  • 78 (a)
ManyToMany
Ugt1a9 36
  • 79 (a)
ManyToMany
Ugt1a9 35
  • 80.4 (n)
  • 79.31 (a)
rat
(Rattus norvegicus)
Mammalia Ugt1a8 35
  • 81.32 (n)
  • 78.87 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 59 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ugt1a7 36
  • 49 (a)
ManyToMany
ugt1b1 36
  • 44 (a)
ManyToMany
ugt1b2 36
  • 45 (a)
ManyToMany
ugt1b3 36
  • 45 (a)
ManyToMany
ugt1b4 36
  • 46 (a)
ManyToMany
ugt1b5 36
  • 44 (a)
ManyToMany
Species with no ortholog for UGT1A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UGT1A10 Gene

ENSEMBL:
Gene Tree for UGT1A10 (if available)
TreeFam:
Gene Tree for UGT1A10 (if available)

Paralogs for UGT1A10 Gene

Pseudogenes.org Pseudogenes for UGT1A10 Gene

genes like me logo Genes that share paralogs with UGT1A10: view

Variants for UGT1A10 Gene

Sequence variations from dbSNP and Humsavar for UGT1A10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_018354 -
VAR_018355 -
VAR_052464 -
VAR_052465 -

Structural Variations from Database of Genomic Variants (DGV) for UGT1A10 Gene

Variant ID Type Subtype PubMed ID
nsv876013 CNV Gain 21882294
nsv876014 CNV Gain 21882294
nsv876015 CNV Loss 21882294
esv2721663 CNV Deletion 23290073
esv2721664 CNV Deletion 23290073
esv24647 CNV Gain 19812545
esv2721666 CNV Deletion 23290073
nsv876016 CNV Gain 21882294
nsv876017 CNV Loss 21882294
esv2721667 CNV Deletion 23290073
nsv3215 CNV Loss 18451855
esv2721668 CNV Deletion 23290073
esv2661542 CNV Deletion 23128226
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061
esv8142 CNV Loss 19470904
esv2721669 CNV Deletion 23290073
nsv876018 CNV Gain 21882294

Variation tolerance for UGT1A10 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT1A10 Gene

HapMap Linkage Disequilibrium report
UGT1A10
Human Gene Mutation Database (HGMD)
UGT1A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A10 Gene

Disorders for UGT1A10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for UGT1A10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pericholangitis
cholelithiasis
crigler-najjar syndrome, type i
  • crigler-najjar syndrome
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT1A10

Genetic Association Database (GAD)
UGT1A10
Human Genome Epidemiology (HuGE) Navigator
UGT1A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT1A10
genes like me logo Genes that share disorders with UGT1A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A10 Gene

Publications for UGT1A10 Gene

  1. UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility. (PMID: 20007297) Balliet R.M. … Lazarus P. (Drug Metab. Dispos. 2010) 3 23 48 67
  2. The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid. (PMID: 9325166) Mojarrabi B. … Mackenzie P.I. (Biochem. Biophys. Res. Commun. 1997) 2 3 23
  3. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. (PMID: 20056724) Brand W. … Rietjens I.M. (Drug Metab. Dispos. 2010) 3 23
  4. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. (PMID: 20297805) Tang L. … Hu M. (Mol. Pharm. 2010) 3 23
  5. Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. (PMID: 19515014) Zhou S.F. … Cai J.P. (Curr. Med. Chem. 2009) 25 26

Products for UGT1A10 Gene

Sources for UGT1A10 Gene

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