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Aliases for UGT1A Gene

Aliases for UGT1A Gene

  • UDP Glucuronosyltransferase Family 1 Member A Complex Locus 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex Locus 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A Cluster 2 3
  • UDP Glycosyltransferase 1 Family, Polypeptide A Cluster 2 3
  • UGT1A@ 3
  • UGT1 3
  • GNT1 3
  • UGT 3

External Ids for UGT1A Gene

Previous HGNC Symbols for UGT1A Gene

  • UGT1A@

Previous GeneCards Identifiers for UGT1A Gene

  • GC02U901997

Summaries for UGT1A Gene

Entrez Gene Summary for UGT1A Gene

  • This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A Gene

UGT1A (UDP Glucuronosyltransferase Family 1 Member A Complex Locus) is a Protein Coding gene. Diseases associated with UGT1A include crigler-najjar syndrome, type i and crigler-najjar syndrome, type ii.

Gene Wiki entry for UGT1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A Gene

Genomics for UGT1A Gene

Genomic Location for UGT1A Gene

Chromosome:
2
Start:
233,585,439 bp from pter
End:
233,773,299 bp from pter
Size:
187,861 bases
Orientation:
Plus strand

Genomic View for UGT1A Gene

Genes around UGT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A Gene

No data available for Regulatory Elements for UGT1A Gene

Proteins for UGT1A Gene

Post-translational modifications for UGT1A Gene

No Post-translational modifications

No data available for DME Specific Peptides for UGT1A Gene

Domains & Families for UGT1A Gene

Gene Families for UGT1A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UGT1A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for UGT1A Gene

Function for UGT1A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A Gene

Localization for UGT1A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for UGT1A Gene

Pathways & Interactions for UGT1A Gene

SuperPathways for UGT1A Gene

No Data Available

Interacting Proteins for UGT1A Gene

Gene Ontology (GO) - Biological Process for UGT1A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UGT1A Gene

Drugs & Compounds for UGT1A Gene

(77) Drugs for UGT1A Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma 864
Atazanavir Approved, Investigational Pharma HIV protease inhibitor,highly potent 0
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1044
Ritonavir Approved, Investigational Pharma HIV protease inhibitor 850
Bilirubin Pharma 103

(49) Additional Compounds for UGT1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UGT1A: view

Transcripts for UGT1A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A Gene

No ASD Table

Relevant External Links for UGT1A Gene

GeneLoc Exon Structure for
UGT1A
ECgene alternative splicing isoforms for
UGT1A

No data available for mRNA/cDNA for UGT1A Gene

Expression for UGT1A Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for UGT1A Gene

Orthologs for UGT1A Gene

No data available for Orthologs and Evolution for UGT1A Gene

Paralogs for UGT1A Gene

No data available for Paralogs for UGT1A Gene

Variants for UGT1A Gene

Relevant External Links for UGT1A Gene

HapMap Linkage Disequilibrium report
UGT1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for UGT1A Gene

Disorders for UGT1A Gene

MalaCards: The human disease database

(3) MalaCards diseases for UGT1A Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
crigler-najjar syndrome, type i
  • crigler-najjar syndrome
crigler-najjar syndrome, type ii
  • crigler najjar syndrome, type 2
irinotecan toxicity
- elite association - COSMIC cancer census association via MalaCards
Search UGT1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for UGT1A

Genetic Association Database (GAD)
UGT1A
Human Genome Epidemiology (HuGE) Navigator
UGT1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT1A
genes like me logo Genes that share disorders with UGT1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A Gene

Publications for UGT1A Gene

  1. A pilot genome-wide association study of early-onset breast cancer. (PMID: 18463975) Kibriya M.G. … Ahsan H. (Breast Cancer Res. Treat. 2009) 3 48 67
  2. Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. (PMID: 18480185) Nakamura A. … Yokoi T. (Drug Metab. Dispos. 2008) 3 23
  3. Expression of UDP-glucuronosyltransferase 1A in bladder cancer: association with prognosis and regulation by estrogen. (PMID: 23143693) Izumi K. … Miyamoto H. (Mol. Carcinog. 2014) 3
  4. Genome-wide association study identifies multiple loci associated with bladder cancer risk. (PMID: 24163127) Figueroa J.D. … Rothman N. (Hum. Mol. Genet. 2014) 3
  5. Genetic determinants influencing human serum metabolome among African Americans. (PMID: 24625756) Yu B. … Boerwinkle E. (PLoS Genet. 2014) 3

Products for UGT1A Gene

Sources for UGT1A Gene

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