UGT1A Gene
protein-coding GIFtS: 14
GCID: GC02U901997
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UDP glucuronosyltransferase 1 family, polypeptide A complex...(Previous names: UDP glycosyltransferase 1 family, polypeptide A cluster,...)
(Previous symbol: UGT1A@)
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Aliases
for UGT1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex Locus1 2 | | UDP Glycosyltransferase 1 Family, Polypeptide A Cluster1 | | UGT1 2 | | GNT12 | | UGT1A@1 2 | | UGT12 | | UDP Glucuronosyltransferase 1 Family, Polypeptide A Cluster1 | | |
Export aliases for UGT1A gene to outside databases |
Summaries
for UGT1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UGT1A:
This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteenunique alternate first exons followed by four common exons. Four of the alternate first exons are consideredpseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteinswith different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulatedby its own promoter. (provided by RefSeq, Jul 2008)
Gene Wiki entry for UGT1A (UGT1A@)
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Genomic Views
for UGT1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for UGT1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for UGT1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A |
Genomic Location:
Chromosome:2
Entrez Gene cytogenetic band: 2q37 HGNC cytogenetic band: 2q37GeneLoc information about chromosome 2 |
Proteins
for UGT1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for UGT1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for UGT1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for UGT1A | |  | Search LifeMap BioReagents cell lines for UGT1A |
Pathways & Interactions
for UGT1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT1A
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Drugs & Compounds
for UGT1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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UGT1A for compounds About GeneDecksing
 Browse Tocris compounds for UGT1A
10/124 Novoseek chemical compound relationships for UGT1A gene (see all 124) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| udp glucuronic acid |
92.3 |
17 |
19821783 (1), 16783480 (1), 17442341 (1), 7866987 (1) (see all 13) |
| uridine diphosphate |
90.5 |
24 |
10340924 (1), 17705660 (1), 19494793 (1), 12376738 (1) (see all 20) |
| glucuronide |
89.1 |
11 |
16518089 (1), 17359941 (1), 9406655 (1), 16595710 (1) (see all 8) |
| 4-methylumbelliferone |
86.5 |
16 |
15190064 (2), 11274859 (1), 15378558 (1), 10220484 (1) (see all 14) |
| 1-naphthol |
83.1 |
8 |
8161205 (1), 11808922 (1), 16906435 (1), 9464459 (1) (see all 7) |
| uridine |
78.4 |
17 |
10419020 (1), 8423545 (1), 15517893 (1), 17214606 (1) (see all 16) |
| glucuronic acid |
77.9 |
10 |
12686489 (1), 9406655 (1), 15845768 (1), 12920162 (1) (see all 10) |
| sn38 glucuronide |
76.8 |
4 |
12019202 (2), 12181437 (1) |
| hecogenin |
76.7 |
1 |
16381668 (1) |
| n-hydroxy phip |
76 |
7 |
11408353 (2), 15310245 (1), 11442279 (1) |
Search CenterWatch for drugs/clinical trials and news about UGT1A 
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Transcripts
for UGT1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Expression
for UGT1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for UGT1A
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat UGT1A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGT1A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT1A |
Orthologs
for UGT1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for UGT1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UGT1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UGT1A: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for UGT1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UGT1A for disorders About GeneDecksing
20/30  diseases for UGT1A (see all 30): About MalaCardscrigler-najjar syndrome estrogen-receptor positive breast cancer brain stem glioma gilbert syndrome
urogenital tuberculosis beta thalassemia breast cancer susceptibility breast cancer
thalassemia viral hepatitis endometrial cancer colon carcinoma
hepatocellular carcinoma autoimmune hepatitis jaundice colon cancer
colorectal cancer diarrhea prostate cancer duodenitis
10/22 Novoseek disease relationships for UGT1A gene (see all 22) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gilberts syndrome |
87.9 |
16 |
8528206 (2), 7648512 (1), 8912353 (1), 11013440 (1) (see all 16) |
| crigler-najjar syndrome |
86.7 |
11 |
7936809 (1), 7648512 (1), 16026101 (1), 12685510 (1) (see all 11) |
| hyperbilirubinemia |
68.7 |
12 |
7936809 (1), 11568299 (1), 16026101 (1), 11013440 (1) (see all 12) |
| crigler-najjar syndrome, type ii |
61.6 |
1 |
8733132 (1) |
| delta hepatitis chronic |
40.1 |
1 |
8942737 (1) |
| colon carcinoma |
34.7 |
1 |
10220484 (1) |
| chemical carcinogenesis |
17.4 |
1 |
7866987 (1) |
| colon cancer |
15.9 |
6 |
14679008 (2), 14667926 (1), 16620709 (1), 17638922 (1) (see all 5) |
| prostate cancer |
15.2 |
4 |
10419020 (1), 18438175 (1), 19069670 (1), 9202245 (1) |
| cancer |
12.9 |
24 |
16550166 (3), 19880377 (2), 19069670 (2), 9564848 (1) (see all 16) |
Human Genome Epidemiology (HuGE) Navigator: UGT1A (293 documents)
Export disorders for UGT1A gene to outside databases
|
Publications
for UGT1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UGT1A gene, integrated from 9 sources (see all 418):
(articles sorted by number of sources associating them with UGT1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. (PubMed id 18480185)1, 9 Nakamura A....Yokoi T. (2008)
- UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry. (PubMed id 15643497)1, 9 Giuliani L....Agliano A.M. (2005)
- Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism. (PubMed id 11915038)1, 9 Kaplan M....Muraca M. (2002)
- The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PubMed id 9295054)1, 9 Mackenzie P.I....Nebert D.W. (1997)
- Gilbert syndrome redefined: a complex genetic haplotyp e influences the regulation of glucuronidation. (PubMed id 22213127)1 Ehmer U....Strassburg C.P. (2012)
- Evaluation of bisphenol A glucuronidation according to UGT1A1*28 polymorphism by a new LC-MS/MS assay. (PubMed id 22154984)1 Trdan Lusin T....Mrhar A. (2012)
- A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. (PubMed id 22558097)1 Milton J.N....Klings E.S. (2012)
- Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk. (PubMed id 22532026)1 Selinski S....Golka K. (2012)
- Study of a family in the province of Matera presenting with glucose-6-phosphate dehydrogenase deficiency and Gilbert's syndrome. (PubMed id 22407023)1 Dell'edera D....Malvasi A. (2012)
- The value of genetic polymorphisms to predict toxicity in metastatic colorectal patients with irinotecan-based regimens. (PubMed id 22535333)1 Lamas M.J....Barros F. (2012)
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External Searches for UGT1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing UGT1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing UGT1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UGT1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UGT1A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for UGT1A gene:
Search GeneIP for patents involving UGT1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UGT1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UGT1A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGT1A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT1A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGT1A |
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| | | | Search Tocris compounds for UGT1A |
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 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for UGT1A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UGT1A |
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