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GIFtS

UGT1A Gene

protein-coding   GIFtS: 15
GCID: GC02U901997

UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex...

(Previous names: UDP glycosyltransferase 1 family, polypeptide A cluster,...)
(Previous symbol: UGT1A@)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex Locus1 2     GNT12
UGT1A@1 2     UGT2
UDP Glucuronosyltransferase 1 Family, Polypeptide A Cluster1     UGT12
UDP Glycosyltransferase 1 Family, Polypeptide A Cluster1     

External Ids:    HGNC: 125291   Entrez Gene: 73612   

Export aliases for UGT1A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGT1A Gene:
This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes
thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are
considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in
nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding
site, and is regulated by its own promoter. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A Gene: 
UGT1A (UDP glucuronosyltransferase 1 family, polypeptide A complex locus) is a protein-coding gene. Diseases associated with UGT1A include lucey-driscoll syndrome, and gilbert syndrome.

Gene Wiki entry for UGT1A (UGT1A@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for UGT1A
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A


Genomic Location:
Chromosome:2   

Entrez Gene cytogenetic band: 2q37   HGNC cytogenetic band: 2q37

GeneLoc information about chromosome 2        


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
UGT: UDP glucuronosyltransferases

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
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Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT1A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
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UGT1A for compounds           About GeneDecksing

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Browse Tocris compounds for UGT1A

10/124 Novoseek inferred chemical compound relationships for UGT1A gene (see all 124)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
udp glucuronic acid 92.3 17 19821783 (1), 16783480 (1), 17442341 (1), 7866987 (1) (see all 13)
uridine diphosphate 90.5 24 10340924 (1), 17705660 (1), 19494793 (1), 12376738 (1) (see all 20)
glucuronide 89.1 11 16518089 (1), 17359941 (1), 9406655 (1), 16595710 (1) (see all 8)
4-methylumbelliferone 86.5 16 15190064 (2), 11274859 (1), 15378558 (1), 10220484 (1) (see all 14)
1-naphthol 83.1 8 8161205 (1), 11808922 (1), 16906435 (1), 9464459 (1) (see all 7)
uridine 78.4 17 10419020 (1), 8423545 (1), 15517893 (1), 17214606 (1) (see all 16)
glucuronic acid 77.9 10 12686489 (1), 9406655 (1), 15845768 (1), 12920162 (1) (see all 10)
sn38 glucuronide 76.8 4 12019202 (2), 12181437 (1)
hecogenin 76.7 1 16381668 (1)
n-hydroxy phip 76 7 11408353 (2), 15310245 (1), 11442279 (1)

Search CenterWatch for drugs/clinical trials and news about UGT1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

    SABiosciences Custom PCR Arrays for UGT1A
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
20/31 diseases for UGT1A (see all 31):    About MalaCards
lucey-driscoll syndrome    gilbert syndrome    crigler-najjar syndrome    urogenital tuberculosis
brain stem glioma    estrogen-receptor positive breast cancer    cholelithiasis    beta thalassemia
autoimmune hepatitis    thalassemia    viral hepatitis    pharyngitis
breast cancer susceptibility    sickle cell anemia    jaundice    diarrhea
duodenitis    cytochrome p450    colon cancer    breast cancer


UGT1A for disorders           About GeneDecksing

10/22 Novoseek inferred disease relationships for UGT1A gene (see all 22)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gilberts syndrome 87.9 16 8528206 (2), 7648512 (1), 8912353 (1), 11013440 (1) (see all 16)
crigler-najjar syndrome 86.7 11 7936809 (1), 7648512 (1), 16026101 (1), 12685510 (1) (see all 11)
hyperbilirubinemia 68.7 12 7936809 (1), 11568299 (1), 16026101 (1), 11013440 (1) (see all 12)
crigler-najjar syndrome, type ii 61.6 1 8733132 (1)
delta hepatitis chronic 40.1 1 8942737 (1)
colon carcinoma 34.7 1 10220484 (1)
chemical carcinogenesis 17.4 1 7866987 (1)
colon cancer 15.9 6 14679008 (2), 14667926 (1), 16620709 (1), 17638922 (1) (see all 5)
prostate cancer 15.2 4 10419020 (1), 18438175 (1), 19069670 (1), 9202245 (1)
cancer 12.9 24 16550166 (3), 19880377 (2), 19069670 (2), 9564848 (1) (see all 16)

Genetic Association Database (GAD): UGT1A
Human Genome Epidemiology (HuGE) Navigator: UGT1A (293 documents)

Export disorders for UGT1A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for UGT1A gene, integrated from 9 sources (see all 424):
(articles sorted by number of sources associating them with UGT1A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A pilot genome-wide association study of early-onset breast cancer. (PubMed id 18463975)1, 4 Kibriya M.G....Ahsan H. (2008)
  2. [Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients] (PubMed id 18478930)1, 4 Wang Y....Li F. (2007)
  3. Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. (PubMed id 18480185)1, 9 Nakamura A....Yokoi T. (2008)
  4. UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry. (PubMed id 15643497)1, 9 Giuliani L....Agliano A.M. (2005)
  5. Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism. (PubMed id 11915038)1, 9 Kaplan M....Muraca M. (2002)
  6. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PubMed id 9295054)1, 9 Mackenzie P.I....Nebert D.W. (1997)
  7. Association of SNPs in the UGT1A gene cluster with tot al bilirubin and mortality in the Diabetes Heart Study. (PubMed id 23642732)1 Cox A.J....Bowden D.W. (2013)
  8. Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer. (PubMed id 23468910)1 Wang M....Li Y.Q. (2013)
  9. Androgen receptor signals regulate UDP-glucuronosyltra nsferases in the urinary bladder: a potential mechanism of androgen-induced blad der carcinogenesis. (PubMed id 22086872)1 Izumi K....Miyamoto H. (2013)
  10. The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glu curonidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decrease d risk of unintentional acetaminophen-induced acute liver failure. (PubMed id 23408116)1 Court M.H....Lee W.M. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 7361 HGNC: 12529 euGenes: HUgn7361 ECgene: UGT1A H-InvDB: UGT1A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for UGT1A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UGT1A gene:
Search GeneIP for patents involving UGT1A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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