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UGT1A Gene

protein-coding   GIFtS: 16
GCID: GC02U901997

UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex...

(Previous names: UDP glycosyltransferase 1 family, polypeptide A cluster,...)
(Previous symbol: UGT1A@)
  See UGT1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex Locus1 2     GNT12
UGT1A@1 2     UGT2
UDP Glucuronosyltransferase 1 Family, Polypeptide A Cluster1     UGT12
UDP Glycosyltransferase 1 Family, Polypeptide A Cluster1     UGT1A105

External Ids:    HGNC: 125291   Entrez Gene: 73612   OMIM: 6064355   

Export aliases for UGT1A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UGT1A Gene:
This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes
thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are
considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in
nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding
site, and is regulated by its own promoter. (provided by RefSeq, Jul 2008)

GeneCards Summary for UGT1A Gene:
UGT1A (UDP glucuronosyltransferase 1 family, polypeptide A complex locus) is a protein-coding gene. Diseases associated with UGT1A include urogenital tuberculosis, and brain stem glioma.

Gene Wiki entry for UGT1A (UGT1A@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for UGT1A
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGT1A


Genomic Location:
Chromosome:2   

Entrez Gene cytogenetic band: 2q37   HGNC cytogenetic band: 2q37

GeneLoc information about chromosome 2        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
UGT: UDP glucuronosyltransferases

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UGT1A
Interactions:

    Search GeneGlobe Interaction Network for UGT1A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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  Browse compounds at ApexBio 

Browse Tocris compounds for UGT1A

Selected Novoseek inferred chemical compound relationships for UGT1A gene (see all 124)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
udp glucuronic acid 92.3 17 19821783 (1), 16783480 (1), 17442341 (1), 7866987 (1) (see all 13)
uridine diphosphate 90.5 24 10340924 (1), 17705660 (1), 19494793 (1), 12376738 (1) (see all 20)
glucuronide 89.1 11 16518089 (1), 17359941 (1), 9406655 (1), 16595710 (1) (see all 8)
4-methylumbelliferone 86.5 16 15190064 (2), 11274859 (1), 15378558 (1), 10220484 (1) (see all 14)
1-naphthol 83.1 8 8161205 (1), 11808922 (1), 16906435 (1), 9464459 (1) (see all 7)
uridine 78.4 17 10419020 (1), 8423545 (1), 15517893 (1), 17214606 (1) (see all 16)
glucuronic acid 77.9 10 12686489 (1), 9406655 (1), 15845768 (1), 12920162 (1) (see all 10)
sn38 glucuronide 76.8 4 12019202 (2), 12181437 (1)
hecogenin 76.7 1 16381668 (1)
n-hydroxy phip 76 7 11408353 (2), 15310245 (1), 11442279 (1)

1 PharmGKB related drug/compound annotation for UGT1A gene    About this table
Drug/compound PharmGKB Annotation
acetaminophenCA  



Find genes that share compounds with UGT1A           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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miRNA
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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

UGT1A Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing UGT1A
DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606435    OMIM disorders: --

5 diseases for UGT1A:    
About MalaCards
urogenital tuberculosis    brain stem glioma    crigler-najjar syndrome    gilbert syndrome
colon cancer


Find genes that share disorders with UGT1A           About GenesLikeMe

Selected Novoseek inferred disease relationships for UGT1A gene (see all 22)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gilberts syndrome 87.9 16 8528206 (2), 7648512 (1), 8912353 (1), 11013440 (1) (see all 16)
crigler-najjar syndrome 86.7 11 7936809 (1), 7648512 (1), 16026101 (1), 12685510 (1) (see all 11)
hyperbilirubinemia 68.7 12 7936809 (1), 11568299 (1), 16026101 (1), 11013440 (1) (see all 12)
crigler-najjar syndrome, type ii 61.6 1 8733132 (1)
delta hepatitis chronic 40.1 1 8942737 (1)
colon carcinoma 34.7 1 10220484 (1)
chemical carcinogenesis 17.4 1 7866987 (1)
colon cancer 15.9 6 14679008 (2), 14667926 (1), 16620709 (1), 17638922 (1) (see all 5)
prostate cancer 15.2 4 10419020 (1), 18438175 (1), 19069670 (1), 9202245 (1)
cancer 12.9 24 16550166 (3), 19880377 (2), 19069670 (2), 9564848 (1) (see all 16)

Genetic Association Database (GAD): UGT1A
Human Genome Epidemiology (HuGE) Navigator: UGT1A (293 documents)

Export disorders for UGT1A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for UGT1A gene, integrated from 10 sources (see all 426):
(articles sorted by number of sources associating them with UGT1A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A pilot genome-wide association study of early-onset breast cancer. (PubMed id 18463975)1, 4 Kibriya M.G....Ahsan H. (Breast Cancer Res. Treat. 2009)
  2. [Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients]. (PubMed id 18478930)1, 4 Wang Y....Li F. (Zhonghua Zhong Liu Za Zhi 2007)
  3. Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. (PubMed id 18480185)1, 9 Nakamura A....Yokoi T. (Drug Metab. Dispos. 2008)
  4. UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry. (PubMed id 15643497)1, 9 Giuliani L....AglianA^ A.M. (Oncol. Rep. 2005)
  5. Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism. (PubMed id 11915038)1, 9 Kaplan M....Muraca M. (Hepatology 2002)
  6. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PubMed id 9295054)1, 9 Mackenzie P.I....Nebert D.W. (Pharmacogenetics 1997)
  7. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. (PubMed id 23642732)1 Cox A.J....Bowden D.W. (Atherosclerosis 2013)
  8. Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer. (PubMed id 23468910)1 Wang M....Li Y.Q. (PLoS ONE 2013)
  9. Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer. (PubMed id 23880823)1 Williamson S.C....Heer R. (Br. J. Cancer 2013)
  10. Androgen receptor signals regulate UDP-glucuronosyltransferases in the urinary bladder: a potential mechanism of androgen-induced bladder carcinogenesis. (PubMed id 22086872)1 Izumi K....Miyamoto H. (Mol. Carcinog. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7361 HGNC: 12529 euGenes: HUgn7361 ECgene: UGT1A H-InvDB: UGT1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UGT1A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UGT1A gene:
Search GeneIP for patents involving UGT1A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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