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Aliases for UGT1A Gene

Aliases for UGT1A Gene

  • UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex Locus 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A Cluster 2 3
  • UDP Glycosyltransferase 1 Family, Polypeptide A Cluster 2 3
  • UGT1A10 6
  • UGT1A@ 3
  • UGT1 3
  • GNT1 3
  • UGT 3

External Ids for UGT1A Gene

Previous HGNC Symbols for UGT1A Gene

  • UGT1A@

Previous GeneCards Identifiers for UGT1A Gene

  • GC02U901997

Summaries for UGT1A Gene

Entrez Gene Summary for UGT1A Gene

  • This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A Gene

UGT1A (UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex Locus) is a Protein Coding gene. Diseases associated with UGT1A include crigler-najjar syndrome, type ii and urogenital tuberculosis. Among its related pathways are Metabolism and Metabolism.

Gene Wiki entry for UGT1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A Gene

Genomics for UGT1A Gene

Genomic Location for UGT1A Gene

Start:
233,585,439 bp from pter
End:
233,773,299 bp from pter
Size:
187,861 bases
Orientation:
Plus strand

Genomic View for UGT1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A Gene

No data available for Regulatory Elements for UGT1A Gene

Proteins for UGT1A Gene

Post-translational modifications for UGT1A Gene

No Post-translational modifications

No data available for DME Specific Peptides for UGT1A Gene

Domains for UGT1A Gene

Gene Families for UGT1A Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UGT1A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for UGT1A Gene

Function for UGT1A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT1A Gene

Localization for UGT1A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for UGT1A Gene

Pathways for UGT1A Gene

genes like me logo Genes that share pathways with UGT1A: view

Interacting Proteins for UGT1A Gene

Gene Ontology (GO) - Biological Process for UGT1A Gene

None

Compounds for UGT1A Gene

(124) Novoseek inferred chemical compound relationships for UGT1A Gene

Compound -log(P) Hits PubMed IDs
udp glucuronic acid 92.3 13
uridine diphosphate 90.5 20
glucuronide 89.1 8
4-methylumbelliferone 86.5 15
1-naphthol 83.1 7

(1) PharmGKB related drug/compound annotations for UGT1A Gene

Drug/compound Annotation
acetaminophen CA
genes like me logo Genes that share compounds with UGT1A: view

Transcripts for UGT1A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A Gene

No ASD Table

Relevant External Links for UGT1A Gene

GeneLoc Exon Structure for
UGT1A
ECgene alternative splicing isoforms for
UGT1A

No data available for mRNA/cDNA for UGT1A Gene

Expression for UGT1A Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for UGT1A Gene

Orthologs for UGT1A Gene

No data available for Orthologs and Evolution for UGT1A Gene

Paralogs for UGT1A Gene

No data available for Paralogs for UGT1A Gene

Variants for UGT1A Gene

Relevant External Links for UGT1A Gene

HapMap Linkage Disequilibrium report
UGT1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for UGT1A Gene

Disorders for UGT1A Gene

(22) Novoseek inferred disease relationships for UGT1A Gene

Disease -log(P) Hits PubMed IDs
gilberts syndrome 87.9 17
crigler-najjar syndrome 86.7 11
hyperbilirubinemia 68.7 12
crigler-najjar syndrome, type ii 61.6 1
delta hepatitis chronic 40.1 1

Relevant External Links for UGT1A

Genetic Association Database (GAD)
UGT1A
Human Genome Epidemiology (HuGE) Navigator
UGT1A
genes like me logo Genes that share disorders with UGT1A: view

No data available for UniProtKB/Swiss-Prot for UGT1A Gene

Publications for UGT1A Gene

  1. Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism. (PMID: 11915038) Kaplan M. … Muraca M. (Hepatology 2002) 3 23
  2. UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry. (PMID: 15643497) Giuliani L. … AglianA^ A.M. (Oncol. Rep. 2005) 3 23
  3. Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. (PMID: 18480185) Nakamura A. … Yokoi T. (Drug Metab. Dispos. 2008) 3 23
  4. A pilot genome-wide association study of early-onset breast cancer. (PMID: 18463975) Kibriya M.G. … Ahsan H. (Breast Cancer Res. Treat. 2009) 3 48
  5. [Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients]. (PMID: 18478930) Wang Y. … Li F. (Zhonghua Zhong Liu Za Zhi 2007) 3 48

Products for UGT1A Gene

Sources for UGT1A Gene

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