Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGP2 Gene

protein-coding   GIFtS: 66
GCID: GC02P063979

UDP-glucose pyrophosphorylase 2

(Previous name: UDP-glucose pyrophosphorylase 1 )
(Previous symbol: UGP1)
 Explore 4 diseases affiliated with
UGP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UGP2    

Aliases
for UGP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP-Glucose Pyrophosphorylase 21 2     UDP-Glucose Diphosphorylase2
UGP11 2 3     UGPase 22
UGPP11 2     Uridyl Diphosphate Glucose Pyrophosphorylase 22
UDP-Glucose Pyrophosphorylase 11 2     Uridyl Diphosphate Glucose Pyrophosphorylase-12
UDPGP2 3     UTP--Glucose-1-Phosphate Uridylyltransferase2
EC 2.7.7.93 8     UTP--Glucose-1-Phosphate Uridylyltransferase 22
UGPP22 5     UTP-Glucose-1-Phosphate Uridyltransferase2
UDPG2     UGPase3
UDPGP22     UDP-Glucose Pyrophosphorylase3
PHC3791     

External Ids:    HGNC: 125271   Entrez Gene: 73602   Ensembl: ENSG000001697647   OMIM: 1917605   UniProtKB: Q168513   

Export aliases for UGP2 gene to outside databases

Previous GC identifers: GC02P064197 GC02P064025 GC02P064042 GC02P063921 GC02P063807


Summaries
for UGP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UGP2:
The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a
glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue,
UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is
then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UGPA_HUMAN, Q16851
Function: Plays a central role as a glucosyl donor in cellular metabolic pathways




Genomic Views
for UGP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGP2 gene promoter:
         MEF-2A   LHX3b/Lhx3b   HFH-1   LHX3a/Lhx3a   aMEF-2   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UGP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14-p13   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p14-p13

UGP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P063979:  view genomic region     (about GC identifiers)

Start:
 64,068,074 bp from pter      End:
 64,118,696 bp from pter
Size:
 50,623 bases      Orientation:
 plus strand

Proteins
for UGP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UGPA_HUMAN, Q16851 (See protein sequence)
Recommended Name: UTP--glucose-1-phosphate uridylyltransferase  
Size: 508 amino acids; 56940 Da
Subunit: Homooctamer (By similarity)
Subcellular location: Cytoplasm
Caution: The human genome was initially thought to contain 2 genes for UTP--glucose-1-phosphate uridylyltransferase:
UGP1 and UGP2. However, the sequence defined as UGP1 (PubMed:8354390) probably does not exist and corresponds to UGP2
2 PDB 3D structures from and Proteopedia for UGP2:
3R2W (3D)        3R3I (3D)    
Secondary accessions: Q07131 Q0P6K2 Q86Y81 Q9BU15
Alternative splicing: 2 isoforms:  Q16851-1   Q16851-2   

Explore the universe of human proteins at neXtProt for UGP2: NX_Q16851

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16851

    • 4/13 DME Specific Peptides for UGP2 (Q16851) (see all 13)
     KLNGGLG  WYPPGHG  FNTNNLW  LMNSFNT 

    UGP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001521.1  NP_006750.3  

    ENSEMBL proteins: 
     ENSP00000377939   ENSP00000418619   ENSP00000418375   ENSP00000419548   ENSP00000420793  
     ENSP00000418179   ENSP00000417286   ENSP00000417801   ENSP00000418206   ENSP00000419019  
     ENSP00000419551   ENSP00000338703   ENSP00000419442   ENSP00000420131   ENSP00000411803  
     ENSP00000420760   ENSP00000418642   ENSP00000419335   ENSP00000417358   ENSP00000420342  
     ENSP00000419238  
    Reactome Protein details: Q16851
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): UGP2
    OriGene Protein Over-expression Lysate (see all 2): UGP2
    OriGene Custom Protein Services for UGP2 
    GenScript Custom Purified and Recombinant Proteins Services for UGP2
    Novus Biologicals UGP2 Proteins
    Novus Biologicals UGP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UGP2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--


    UGP2 for ontologies           About GeneDecksing



    UGP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UGP2 
    GenScript Custom Superior Antibodies Services for UGP2
    Novus Biologicals UGP2 Antibodies
    Abcam antibodies for UGP2 
    Uscn Antibodies for UGP2
    ThermoFisher Antibodies for UGP2

    Assay Products for UGP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UGP2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for UGP2

    Protein Domains /
    Families
    for UGP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UGP2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016267 UDPGP_trans_subgr
     IPR002618 UDPGP_trans

    Graphical View of Domain Structure for InterPro Entry Q16851

    ProtoNet protein and cluster: Q16851

    1 Blocks protein family: IPB002618 UTP--glucose-1-phosphate uridylyltransferase

    UniProtKB/Swiss-Prot: UGPA_HUMAN, Q16851
    Similarity: Belongs to the UDPGP type 1 family


    Function
    for UGP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UGPA_HUMAN, Q16851
    Function: Plays a central role as a glucosyl donor in cellular metabolic pathways
    Catalytic activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose

         Genatlas biochemistry entry for UGP2:
    UDP glucose pyrophosphorylase 2,muscle isoform,may be the same as GLAT

    Enzyme Number (IUBMB): EC 2.7.7.91 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): UGP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UGP2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate UGP2 (see all 10):
    hsa-miR-16-2* hsa-miR-92a hsa-miR-137 hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-4325 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmid: UGP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGP2 (see all 7)
    OriGene shRNA RFP: UGP2
    OriGene siRNA: UGP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGP2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UGP2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGP2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGP2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): UGP2 (NM_006759)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGP2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for UGP2
    Search LifeMap BioReagents cell lines for UGP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGP2

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003983UTP:glucose-1-phosphate uridylyltransferase activity TAS8354390
    GO:0005515protein binding IPI17474147
    GO:0005536glucose binding ----
    GO:0016779nucleotidyltransferase activity ----
    GO:0032557pyrimidine ribonucleotide binding ----


    UGP2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for UGP2:
     Decreased telomerase activity  Decreased viability of wild-ty 

    Animal Models:
         1 MGI phenotypic allele for Ugp2 (no phenotypes)

    UGP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UGP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    		Glucuronidation1.00
    		Starch and sucrose metabolism0.42
    		Glucuronidation0.67
    2Galactose metabolism
    		Galactose metabolism0.47
    		Glycogen metabolism0.40
    		Glycogen metabolism0.40
    3Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    4glycogen biosynthesis II (from UDP-D-Glucose)
    		glycogen biosynthesis II (from UDP-D-Glucose)1.00
    		Glycogen synthesis0.75
    5Biological oxidations
    		Biological oxidations1.00
    		Phase II conjugation0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for UGP2
        Glycogen metabolism


    1 GeneGo (Thomson Reuters) Pathway for UGP2
        Glycogen metabolism

    5 BioSystems Pathways for UGP2 
        Glucuronidation
    Glycogen Metabolism
    Diurnally regulated genes with circadian orthologs
    glycogen biosynthesis II (from UDP-D-Glucose)
    colanic acid building blocks biosynthesis

    5/8        Reactome Pathways for UGP2 (see all 8)
        Metabolism of carbohydrates
    Formation of the active cofactor, UDP-glucuronate
    Metabolism
    Biological oxidations
    Glucose metabolism


    5         Kegg Pathways  (Kegg details for UGP2):
        Pentose and glucuronate interconversions
    Galactose metabolism
    Starch and sucrose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways


    UGP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for UGP2 (Q168511, 2, 3 ENSP000003387034) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBP1Q153652, 3, ENSP000003055564MINT-2863974 I2D: score=3 STRING: ENSP00000305556
    ARIH2O953762, 3, ENSP000003487694MINT-66379 I2D: score=5 STRING: ENSP00000348769
    GRB2P629931, 3, ENSP000003390074EBI-1964706,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    NOP58Q9Y2X33, ENSP000002642794I2D: score=3 STRING: ENSP00000264279
    PUF60Q9UHX13, ENSP000003220164I2D: score=2 STRING: ENSP00000322016
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005978glycogen biosynthetic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006011UDP-glucose metabolic process TAS8631325
    GO:0006065UDP-glucuronate biosynthetic process TAS--


    UGP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UGP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGP2

    5 HMDB Compounds for UGP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glucose 1-phosphateCori ester (see all 22)59-56-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Uridine diphosphate glucose(UPD)-glucose (see all 24)133-89-1--
    Uridine triphosphate5'-UTP (see all 7)63-39-8--
    Search CenterWatch for drugs/clinical trials and news about UGP2 / UGPA 

    Transcripts
    for UGP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UGP2 gene (2 alternative transcripts): 
    NM_001001521.1  NM_006759.3  

    Unigene Cluster for UGP2:

    UDP-glucose pyrophosphorylase 2
    Hs.516217  [show with all ESTs]
    Unigene Representative Sequence: BX537559
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000394417(uc002scl.3) ENST00000466642 ENST00000484142 ENST00000482668
    ENST00000467648 ENST00000497510 ENST00000483461 ENST00000480679 ENST00000483108
    ENST00000487469 ENST00000493222 ENST00000467400 ENST00000487640 ENST00000337130(uc002scm.3)
    ENST00000475550 ENST00000484056 ENST00000488245 ENST00000497883

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): UGP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UGP2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate UGP2 (see all 10):
    hsa-miR-16-2* hsa-miR-92a hsa-miR-137 hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-4325 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmid: UGP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGP2 (see all 7)
    OriGene shRNA RFP: UGP2
    OriGene siRNA: UGP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGP2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGP2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGP2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): UGP2 (NM_006759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGP2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UGP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGP2

    Additional cDNA sequence: 

    AF086113.1 AK094167.1 AK300731.1 AK314263.1 BC000173.2 BC002954.1 BC047004.1 BX537559.1 
    U00954.1 U27460.1 

    24/39 DOTS entries (see all 39):

    DT.91676582  DT.91768014  DT.95169422  DT.91767990  DT.100878135  DT.100878150  DT.120929472  DT.97815315 
    DT.91767994  DT.100878142  DT.120929517  DT.120929578  DT.120929583  DT.40309792  DT.100878130  DT.120929538 
    DT.121642969  DT.91795647  DT.120929520  DT.120929559  DT.100878141  DT.100878149  DT.120929502  DT.120929506 

    24/601 AceView cDNA sequences (see all 601):

    AI384048 N67853 AA948261 CA423001 W03456 CK819511 CR617685 BM313463 
    BG754488 R58578 BM854041 AV654212 AA664364 BM473685 AU126119 BU607659 
    N36050 BG621255 BX474182 AW951355 CN479605 AI537903 CA417277 CB156513 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for UGP2 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
    SP1:              -     -     -     -     -     -     -           -     -                 -                                               -               
    SP2:                    -     -     -     -     -     -           -     -                 -                                               -               
    SP3:              -     -     -     -     -     -     -           -                       -                                                               
    SP4:                                                              -     -                 -                                                               
    SP5:                                      -     -     -           -     -                 -                                                               


    ECgene alternative splicing isoforms for UGP2

    Expression
    for UGP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGACAGAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UGP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Matrigel embedded cells (Derivation of cardio...)

    See UGP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGP2

    SOURCE GeneReport for Unigene cluster: Hs.516217
        SABiosciences Expression via Pathway-Focused PCR Array including UGP2: 
              Glucose Metabolism in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UGP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGP2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGP2

    Orthologs
    for UGP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UGP2 gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ugp21 , 5 UDP-glucose pyrophosphorylase 21, 5 92.19(n)1
    98.82(a)1    		   11 (13.89 cM)5
    2165581  NM_139297.51  NP_647458.11 
     213211385 
    chicken
    (Gallus gallus)    		 Aves UGP21 UDP-glucose pyrophosphorylase 2 81.1(n)
    93.1(a)    		   373900  NM_204111.1  NP_989442.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UGP26
    		 --
    		 91(a)
    		 1 ↔ 1
    		 1(120518142-120534520)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686152 hypothetical protein MGC68615 78.29(n)    BC060013.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi53h102 Danio rerio cDNA clone IMAGE2641411, partial cds 76.33(n)    BC054939.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG43473
    UGP1    		 UTP-glucose-1-phosphate uridylyltransferase3
    CG4347-PA1    		 63(a)3
    61.85(n)1
    63.75(a)1    		   390651  NM_168325.31  NP_729469.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea K08E3.5a3
    K08E3.51    		 UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
    (EC more3
    Protein K08E3.51    		 66(a)
    (best of 5)3
    59.96(n)1
    65.65(a)1    		   III(13835572-13837436)3
    1768141  NM_067441.21  NP_499842.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AtUGP26
    UGP6
    		 UTP--glucose-1-phosphate uridylyltransferase 1
    putative UTP--glucose-1-phosphate uridylyltransfer...
    		 53(a)
    52(a)
    		 many → 1
    many → 1
    		 5(5696645-5700922)
    3(749390-754159)
    rice
    (Oryza sativa)    		 Liliopsida Os.101182 Oryza sativa (japonica cultivar-group) UGP mRNA for more 73.16(n)    AB062606.1 


    ENSEMBL Gene Tree for UGP2 (if available)
    TreeFam Gene Tree for UGP2 (if available) 

    Paralogs
    for UGP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for UGP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/819 NCBI SNPs in UGP2 are shown (see all 819)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1458917571,2
    		--64066196(+) AGTTAA/GTTACT 1 -- us2k10--------
    rs130017071,2
    		C--64066231(+) AGTGTA/CCAACA 1 -- us2k10--------
    rs1384859391,2
    		--64066344(+) AATCTC/TCCATG 1 -- us2k10--------
    rs1916474951,2
    		--64066422(+) GGCGCG/TGTGGC 1 -- us2k10--------
    rs1838701911,2
    		--64066490(+) GGTTTG/TAGACC 1 -- us2k10--------
    rs1893158171,2
    		--64066650(+) CTGTGC/TCATTG 1 -- us2k10--------
    rs1808037231,2
    		--64066738(+) CTTCAC/TTGTCC 1 -- us2k10--------
    rs1414556471,2
    		--64066768(+) GTAACC/GCTACG 1 -- us2k10--------
    rs1857985761,2
    		--64066887(+) TTTTGC/TTAAGA 1 -- us2k10--------
    rs1474954971,2
    		--64066945(+) AGACAC/TTTGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UGP2 (64068074 - 64118696 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for UGP2
         3 CNVs: 67880 89689 97873

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGP2
    DNA2.0 Custom Variant and Variant Library Synthesis for UGP2

    Disorders / Diseases
    for UGP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UGP2 for disorders           About GeneDecksing

    OMIM gene information: 191760    OMIM disorders: --

    4 diseases for UGP2:    About MalaCards
    galactosemia    choroiditis    ataxia    hypoxia

    2 diseases from the University of Copenhagen DISEASES database for UGP2:
    Galactosemia     Bilirubin metabolic disorder
    Human Genome Epidemiology (HuGE) Navigator: UGP2 (1 document)

    Export disorders for UGP2 gene to outside databases

    Publications
    for UGP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGP2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with UGP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli. (PubMed id 8631325)1, 2 Duggleby R.G.... Chang H.-Y. (1996)
    3. The importance of conserved residues in human liver UDPglucose pyrophosphorylase. (PubMed id 8612650)1, 2 Chang H.-Y.... Duggleby R.G. (1996)
    4. Cloning of a human liver UDP-glucose pyrophosphorylase cDNA by complementation of the bacterial galU mutation. (PubMed id 8354390)1, 2 Peng H.-L. and Chang H.-Y. (1993)
    5. Hypoxia promotes glycogen accumulation through hypoxi a inducible factor (HIF)-mediated induction of glycogen synthase 1. (PubMed id 20300197)1, 9 Pescador N....del Peso L. (2010)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. The crystal structure of human UDP-glucose pyrophospho rylase reveals a latch effect that influences enzymatic activity. (PubMed id 22132858)1 Yu Q. and Zheng X. (2012)
    9. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for UGP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UGP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7360 HGNC: 12527 AceView: UGP2 Ensembl:ENSG00000169764 euGenes: HUgn7360
    ECgene: UGP2 Kegg: 7360 H-InvDB: UGP2

    Other Databases showing UGP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UGP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UGP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UGP2 gene:
    Search GeneIP for patents involving UGP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for UGP2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for UGP2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGP2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGP2  
     OriGene Protein Over-expression Lysate for UGP2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for UGP2   OriGene 3'-UTR Clone for UGP2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGP2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGP2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for UGP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UGP2   OriGene Custom Protein Services for UGP2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UGP2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGP2
     GenScript Custom Purified and Recombinant Proteins Services for UGP2 GenScript cDNA clones with any tag delivered in your preferred vector for UGP2
     GenScript Custom Assay Services for UGP2 GenScript Custom Superior Antibodies Services for UGP2
     GenScript Custom overexpressing Cell Line Services for UGP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UGP2 promoter
     Search Chromatin IP Primers for UGP2
     RT2 qPCR Primer Assay in human, mouse, rat UGP2
     Search GNC Networks for UGP2
     SABiosciences PCR Arrays including human, mouse, rat UGP2
     Search Tocris compounds for UGP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UGP2 antibodies
     UGP2 proteins
     UGP2 lysates
     Antibodies for UGP2
     See all of Abcam's Antibodies, Kits and Proteins for UGP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     UGP2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for UGP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGP2
     SwitchGear 3'UTR luciferase reporter plasmids for UGP2
     SwitchGear Promoter luciferase reporter plasmids for UGP2
     ThermoFisher Antibodies for UGP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGP2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      UGP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4