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Aliases for UGP2 Gene

Aliases for UGP2 Gene

  • UDP-Glucose Pyrophosphorylase 2 2 3 5
  • UDP-Glucose Pyrophosphorylase 1 2 3
  • EC 2.7.7.9 4 63
  • UDPGP 3 4
  • UGP1 3 4
  • UTP--Glucose-1-Phosphate Uridylyltransferase 2 3
  • Uridyl Diphosphate Glucose Pyrophosphorylase-1 3
  • Uridyl Diphosphate Glucose Pyrophosphorylase 2 3
  • Testis Tissue Sperm-Binding Protein Li 58p 3
  • UTP-Glucose-1-Phosphate Uridyltransferase 3
  • UDP-Glucose Pyrophosphorylase 4
  • UDP-Glucose Diphosphorylase 3
  • UGPase 2 3
  • UDPGP2 3
  • PHC379 3
  • UGPase 4
  • UGPP1 3
  • UGPP2 3
  • UDPG 3

External Ids for UGP2 Gene

Previous HGNC Symbols for UGP2 Gene

  • UGP1

Previous GeneCards Identifiers for UGP2 Gene

  • GC02P064197
  • GC02P064025
  • GC02P064042
  • GC02P063979
  • GC02P063921
  • GC02P063807
  • GC02P064068

Summaries for UGP2 Gene

Entrez Gene Summary for UGP2 Gene

  • The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGP2 Gene

UGP2 (UDP-Glucose Pyrophosphorylase 2) is a Protein Coding gene. Among its related pathways are Amino sugar and nucleotide sugar metabolism and Galactose metabolism. GO annotations related to this gene include identical protein binding and uridylyltransferase activity.

UniProtKB/Swiss-Prot for UGP2 Gene

  • Plays a central role as a glucosyl donor in cellular metabolic pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGP2 Gene

Genomics for UGP2 Gene

Regulatory Elements for UGP2 Gene

Enhancers for UGP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UGP2 on UCSC Golden Path with GeneCards custom track

Promoters for UGP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UGP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGP2 Gene

Chromosome:
2
Start:
63,840,940 bp from pter
End:
63,891,562 bp from pter
Size:
50,623 bases
Orientation:
Plus strand

Genomic View for UGP2 Gene

Genes around UGP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGP2 Gene

Proteins for UGP2 Gene

  • Protein details for UGP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16851-UGPA_HUMAN
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    Protein Accession:
    Q16851
    Secondary Accessions:
    • Q07131
    • Q0P6K2
    • Q86Y81
    • Q9BU15

    Protein attributes for UGP2 Gene

    Size:
    508 amino acids
    Molecular mass:
    56940 Da
    Quaternary structure:
    • Homooctamer.

    Three dimensional structures from OCA and Proteopedia for UGP2 Gene

    Alternative splice isoforms for UGP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGP2 Gene

Proteomics data for UGP2 Gene at MOPED

Post-translational modifications for UGP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UGP2 Gene

Suggested Antigen Peptide Sequences for UGP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16851

UniProtKB/Swiss-Prot:

UGPA_HUMAN :
  • Belongs to the UDPGP type 1 family.
Family:
  • Belongs to the UDPGP type 1 family.
genes like me logo Genes that share domains with UGP2: view

No data available for Gene Families for UGP2 Gene

Function for UGP2 Gene

Molecular function for UGP2 Gene

GENATLAS Biochemistry:
UDP glucose pyrophosphorylase 2,muscle isoform,may be the same as GLAT
UniProtKB/Swiss-Prot CatalyticActivity:
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
UniProtKB/Swiss-Prot Function:
Plays a central role as a glucosyl donor in cellular metabolic pathways.

Enzyme Numbers (IUBMB) for UGP2 Gene

Gene Ontology (GO) - Molecular Function for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity TAS 8354390
genes like me logo Genes that share ontologies with UGP2: view
genes like me logo Genes that share phenotypes with UGP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UGP2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGP2 Gene

Localization for UGP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGP2 Gene COMPARTMENTS Subcellular localization image for UGP2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 1
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UGP2: view

Pathways & Interactions for UGP2 Gene

genes like me logo Genes that share pathways with UGP2: view

Gene Ontology (GO) - Biological Process for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006011 UDP-glucose metabolic process IEA --
GO:0019255 glucose 1-phosphate metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with UGP2: view

No data available for SIGNOR curated interactions for UGP2 Gene

Drugs & Compounds for UGP2 Gene

(3) Drugs for UGP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0
Glucose 1-phosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(2) Additional Compounds for UGP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Uridine diphosphate glucose
  • (UDP)glucose
  • (UPD)-glucose
  • UDP Glucose
  • UDP-a-D-Glucose
  • UDP-alpha-D-Glucose
133-89-1
genes like me logo Genes that share compounds with UGP2: view

Transcripts for UGP2 Gene

Unigene Clusters for UGP2 Gene

UDP-glucose pyrophosphorylase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP10: - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14:

Relevant External Links for UGP2 Gene

GeneLoc Exon Structure for
UGP2
ECgene alternative splicing isoforms for
UGP2

Expression for UGP2 Gene

mRNA expression in normal human tissues for UGP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGP2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for UGP2 Gene

This gene is overexpressed in Liver, secretome (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGP2 Gene



SOURCE GeneReport for Unigene cluster for UGP2 Gene Hs.516217

genes like me logo Genes that share expression patterns with UGP2: view

Protein tissue co-expression partners for UGP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UGP2 Gene

Orthologs for UGP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UGP2 35
  • 93.57 (n)
  • 98.82 (a)
UGP2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UGP2 35
  • 93.44 (n)
  • 98.23 (a)
UGP2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ugp2 35
  • 92.19 (n)
  • 98.82 (a)
Ugp2 16
Ugp2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UGP2 35
  • 99.74 (n)
  • 100 (a)
UGP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugp2 35
  • 91.34 (n)
  • 99.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UGP2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves UGP2 35
  • 81.1 (n)
  • 93.1 (a)
UGP2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UGP2 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ugp2 35
  • 75.79 (n)
  • 89.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68615 35
zebrafish
(Danio rerio)
Actinopterygii wufi53h10 35
ugp2a 36
  • 82 (a)
OneToMany
ugp2b 36
  • 84 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10939 35
fruit fly
(Drosophila melanogaster)
Insecta CG4347 37
  • 63 (a)
UGP 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea D1005.2 37
  • 39 (a)
K08E3.5a 37
  • 66 (a)
K08E3.5b 37
  • 64 (a)
K08E3.5c 37
  • 66 (a)
K08E3.5d 37
  • 62 (a)
K08E3.5 35
  • 59.96 (n)
  • 65.65 (a)
K08E3.5 36
  • 62 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UGP1 36
  • 53 (a)
OneToOne
UGP1 38
soybean
(Glycine max)
eudicotyledons Gma.6257 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7436 35
barley
(Hordeum vulgare)
Liliopsida Hv.19 35
rice
(Oryza sativa)
Liliopsida Os.10118 35
wheat
(Triticum aestivum)
Liliopsida Ta.542 35
corn
(Zea mays)
Liliopsida Zm.9568 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4853 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6144 36
  • 63 (a)
OneToOne
Species with no ortholog for UGP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UGP2 Gene

ENSEMBL:
Gene Tree for UGP2 (if available)
TreeFam:
Gene Tree for UGP2 (if available)

Paralogs for UGP2 Gene

No data available for Paralogs for UGP2 Gene

Variants for UGP2 Gene

Sequence variations from dbSNP and Humsavar for UGP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_033042 -
rs1133069 -- 63,878,842(+) attac(A/T)gatgt intron-variant
rs8179567 -- 63,887,699(+) ATAAA(A/G)ATATG intron-variant
rs3924029 -- 63,874,435(-) GGCAA(A/T)ATAAC intron-variant
rs10166971 -- 63,890,810(+) AGGTT(A/G)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGP2 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
esv2720141 CNV Deletion 23290073
esv2470969 CNV Deletion 19546169
esv2720142 CNV Deletion 23290073
esv2658650 CNV Deletion 23128226
esv21925 CNV Loss 19812545
nsv521717 CNV Gain 19592680
esv2720143 CNV Deletion 23290073
esv2720144 CNV Deletion 23290073
esv2720145 CNV Deletion 23290073
esv2720146 CNV Deletion 23290073
esv2720147 CNV Deletion 23290073
esv2741858 CNV Deletion 23290073

Variation tolerance for UGP2 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGP2 Gene

HapMap Linkage Disequilibrium report
UGP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGP2 Gene

Disorders for UGP2 Gene

Relevant External Links for UGP2

Genetic Association Database (GAD)
UGP2
Human Genome Epidemiology (HuGE) Navigator
UGP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGP2

No disorders were found for UGP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGP2 Gene

Publications for UGP2 Gene

  1. The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. (PMID: 22132858) Yu Q. … Zheng X. (Biochem. J. 2012) 3 4 67
  2. Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. (PMID: 20300197) Pescador N. … del Peso L. (PLoS ONE 2010) 3 23
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for UGP2 Gene

Sources for UGP2 Gene

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