Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UGP2 Gene

Aliases for UGP2 Gene

  • UDP-Glucose Pyrophosphorylase 2 2 3 5
  • UTP--Glucose-1-Phosphate Uridylyltransferase 2 3
  • UDP-Glucose Pyrophosphorylase 1 2 3
  • EC 2.7.7.9 4 61
  • UDPGP 3 4
  • UGP1 3 4
  • UTP--Glucose-1-Phosphate Uridylyltransferase 2 3
  • Uridyl Diphosphate Glucose Pyrophosphorylase-1 3
  • Uridyl Diphosphate Glucose Pyrophosphorylase 2 3
  • Testis Tissue Sperm-Binding Protein Li 58p 3
  • UTP-Glucose-1-Phosphate Uridyltransferase 3
  • UDP-Glucose Pyrophosphorylase 4
  • UDP-Glucose Diphosphorylase 3
  • UGPase 2 3
  • UDPGP2 3
  • PHC379 3
  • UGPase 4
  • UGPP1 3
  • UGPP2 3
  • UDPG 3

External Ids for UGP2 Gene

Previous HGNC Symbols for UGP2 Gene

  • UGP1

Previous GeneCards Identifiers for UGP2 Gene

  • GC02P064197
  • GC02P064025
  • GC02P064042
  • GC02P063979
  • GC02P063921
  • GC02P063807
  • GC02P064068

Summaries for UGP2 Gene

Entrez Gene Summary for UGP2 Gene

  • The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGP2 Gene

UGP2 (UDP-Glucose Pyrophosphorylase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include identical protein binding and uridylyltransferase activity.

UniProtKB/Swiss-Prot for UGP2 Gene

  • Plays a central role as a glucosyl donor in cellular metabolic pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGP2 Gene

Genomics for UGP2 Gene

Regulatory Elements for UGP2 Gene

Enhancers for UGP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F063698 1.1 Ensembl ENCODE 17.3 -141.9 -141852 1.8 ELF3 TBP ARID4B ZNF48 ZSCAN9 ZNF2 RAD21 RFX5 YY1 SLC30A9 UGP2 GC02P063684 LOC100418973
GH02F063862 0.6 ENCODE 11.4 +22.3 22342 2.2 POLR2A NSD2 UGP2 WDPCP MDH1 LOC100507006 ENSG00000251775
GH02F063861 0.5 ENCODE 11.4 +20.5 20462 0.2 CTCF MAX REST RAD21 SCRT2 SMC3 ZBTB33 HOMEZ UGP2 ENSG00000251775
GH02F063874 0.4 ENCODE 11.4 +34.7 34695 2.4 JUND PKNOX1 ZBTB48 POLR2A IKZF1 JUNB TCF7 PRDM10 UGP2 LOC100507006 ENSG00000251775
GH02F063819 0.9 Ensembl ENCODE 11.2 -20.7 -20740 1.2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 NFYC MXD4 WDPCP UGP2 GC02M063810 GC02M063754
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UGP2 on UCSC Golden Path with GeneCards custom track

Promoters for UGP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001045127 1660 5601 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for UGP2 Gene

Chromosome:
2
Start:
63,840,940 bp from pter
End:
63,891,562 bp from pter
Size:
50,623 bases
Orientation:
Plus strand

Genomic View for UGP2 Gene

Genes around UGP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGP2 Gene

Proteins for UGP2 Gene

  • Protein details for UGP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16851-UGPA_HUMAN
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    Protein Accession:
    Q16851
    Secondary Accessions:
    • Q07131
    • Q0P6K2
    • Q86Y81
    • Q9BU15

    Protein attributes for UGP2 Gene

    Size:
    508 amino acids
    Molecular mass:
    56940 Da
    Quaternary structure:
    • Homooctamer.

    Three dimensional structures from OCA and Proteopedia for UGP2 Gene

    Alternative splice isoforms for UGP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGP2 Gene

Post-translational modifications for UGP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UGP2 Gene

Suggested Antigen Peptide Sequences for UGP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16851

UniProtKB/Swiss-Prot:

UGPA_HUMAN :
  • Belongs to the UDPGP type 1 family.
Family:
  • Belongs to the UDPGP type 1 family.
genes like me logo Genes that share domains with UGP2: view

No data available for Gene Families for UGP2 Gene

Function for UGP2 Gene

Molecular function for UGP2 Gene

GENATLAS Biochemistry:
UDP glucose pyrophosphorylase 2,muscle isoform,may be the same as GLAT
UniProtKB/Swiss-Prot CatalyticActivity:
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
UniProtKB/Swiss-Prot Function:
Plays a central role as a glucosyl donor in cellular metabolic pathways.

Enzyme Numbers (IUBMB) for UGP2 Gene

Gene Ontology (GO) - Molecular Function for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity TAS 8354390
GO:0005515 protein binding IPI 16189514
GO:0005536 glucose binding IEA --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with UGP2: view
genes like me logo Genes that share phenotypes with UGP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UGP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGP2 Gene

Localization for UGP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGP2 Gene COMPARTMENTS Subcellular localization image for UGP2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 1
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UGP2: view

Pathways & Interactions for UGP2 Gene

genes like me logo Genes that share pathways with UGP2: view

Gene Ontology (GO) - Biological Process for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IBA --
GO:0005978 glycogen biosynthetic process TAS --
GO:0006011 UDP-glucose metabolic process IEA --
GO:0006065 UDP-glucuronate biosynthetic process TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with UGP2: view

No data available for SIGNOR curated interactions for UGP2 Gene

Drugs & Compounds for UGP2 Gene

(4) Drugs for UGP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Glucose 1-phosphate Experimental Pharma 0
Uridine diphosphate glucose Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0

(1) Additional Compounds for UGP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UGP2: view

Transcripts for UGP2 Gene

Unigene Clusters for UGP2 Gene

UDP-glucose pyrophosphorylase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP10: - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14:

Relevant External Links for UGP2 Gene

GeneLoc Exon Structure for
UGP2
ECgene alternative splicing isoforms for
UGP2

Expression for UGP2 Gene

mRNA expression in normal human tissues for UGP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGP2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for UGP2 Gene

This gene is overexpressed in Liver, secretome (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGP2 Gene



Protein tissue co-expression partners for UGP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGP2 Gene:

UGP2

SOURCE GeneReport for Unigene cluster for UGP2 Gene:

Hs.516217
genes like me logo Genes that share expression patterns with UGP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UGP2 Gene

Orthologs for UGP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGP2 34 35
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UGP2 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGP2 34 35
  • 93.57 (n)
dog
(Canis familiaris)
Mammalia UGP2 34 35
  • 93.44 (n)
mouse
(Mus musculus)
Mammalia Ugp2 34 16 35
  • 92.19 (n)
rat
(Rattus norvegicus)
Mammalia Ugp2 34
  • 91.34 (n)
chicken
(Gallus gallus)
Aves UGP2 34 35
  • 81.1 (n)
lizard
(Anolis carolinensis)
Reptilia UGP2 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ugp2 34
  • 75.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68615 34
zebrafish
(Danio rerio)
Actinopterygii ugp2b 35
  • 84 (a)
OneToMany
ugp2a 35
  • 82 (a)
OneToMany
wufi53h10 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10939 34
fruit fly
(Drosophila melanogaster)
Insecta CG4347 36
  • 63 (a)
UGP 35
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K08E3.5a 36
  • 66 (a)
K08E3.5c 36
  • 66 (a)
K08E3.5b 36
  • 64 (a)
K08E3.5d 36
  • 62 (a)
K08E3.5 34 35
  • 59.96 (n)
D1005.2 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UGP1 35 37
  • 53 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.6257 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7436 34
barley
(Hordeum vulgare)
Liliopsida Hv.19 34
rice
(Oryza sativa)
Liliopsida Os.10118 34
wheat
(Triticum aestivum)
Liliopsida Ta.542 34
corn
(Zea mays)
Liliopsida Zm.9568 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6144 35
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4853 34
Species where no ortholog for UGP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UGP2 Gene

ENSEMBL:
Gene Tree for UGP2 (if available)
TreeFam:
Gene Tree for UGP2 (if available)

Paralogs for UGP2 Gene

No data available for Paralogs for UGP2 Gene

Variants for UGP2 Gene

Sequence variations from dbSNP and Humsavar for UGP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10166971 -- 63,890,810(+) AGGTT(A/G)GATAA intron-variant
rs10168339 -- 63,878,589(+) ACTCA(A/G)AACGT intron-variant
rs10175439 -- 63,867,987(+) TGACT(A/G)TTTTG intron-variant
rs10183479 -- 63,857,980(+) CTTGG(A/G)CACTG intron-variant
rs10194684 -- 63,842,373(+) TGACG(C/T)TCCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UGP2 Gene

Variant ID Type Subtype PubMed ID
esv21925 CNV loss 19812545
esv2470969 CNV deletion 19546169
esv2658650 CNV deletion 23128226
esv2720141 CNV deletion 23290073
esv2720142 CNV deletion 23290073
esv2720143 CNV deletion 23290073
esv2720144 CNV deletion 23290073
esv2720145 CNV deletion 23290073
esv2720146 CNV deletion 23290073
esv2720147 CNV deletion 23290073
esv2741858 CNV deletion 23290073
esv3591066 CNV loss 21293372
nsv521717 CNV gain 19592680
nsv582126 CNV gain 21841781
nsv582127 CNV gain 21841781
nsv7313 OTHER inversion 18451855

Variation tolerance for UGP2 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGP2 Gene

Disorders for UGP2 Gene

Relevant External Links for UGP2

Genetic Association Database (GAD)
UGP2
Human Genome Epidemiology (HuGE) Navigator
UGP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGP2

No disorders were found for UGP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGP2 Gene

Publications for UGP2 Gene

  1. The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. (PMID: 22132858) Yu Q. … Zheng X. (Biochem. J. 2012) 3 4 64
  2. Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. (PMID: 20300197) Pescador N. … del Peso L. (PLoS ONE 2010) 3 22 64
  3. Variants of organic anion transporter polypeptide 2 gene are not risk factors associated with severe neonatal hyperbilirubinemia. (PMID: 20514852) Wong F.L. … Wang M.K. (Malays J Pathol 2009) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The importance of conserved residues in human liver UDPglucose pyrophosphorylase. (PMID: 8612650) Chang H.-Y. … Duggleby R.G. (Eur. J. Biochem. 1996) 3 4 64

Products for UGP2 Gene

Sources for UGP2 Gene

Content
Loading form....