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Aliases for UGGT2 Gene

Aliases for UGGT2 Gene

  • UDP-Glucose Glycoprotein Glucosyltransferase 2 2 3 5
  • UDP-Glucose Ceramide Glucosyltransferase-Like 1 3 4
  • UDP-Glucose Ceramide Glucosyltransferase-Like 2 2 3
  • UDP--Glc:Glycoprotein Glucosyltransferase 2 3 4
  • UGCGL2 3 4
  • HUGT2 3 4
  • UGT2 3 4
  • UDP-Glucose:Glycoprotein Glucosyltransferase 2 2
  • UDP-Glc:Glycoprotein Glucosyltransferase 2 3
  • EC 2.4.1.- 4
  • EC 2.4.1 63

External Ids for UGGT2 Gene

Previous HGNC Symbols for UGGT2 Gene

  • UGCGL2

Previous GeneCards Identifiers for UGGT2 Gene

  • GC13M095252
  • GC13M096453
  • GC13M077051

Summaries for UGGT2 Gene

Entrez Gene Summary for UGGT2 Gene

  • UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]

GeneCards Summary for UGGT2 Gene

UGGT2 (UDP-Glucose Glycoprotein Glucosyltransferase 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Protein processing in endoplasmic reticulum. GO annotations related to this gene include transferase activity, transferring glycosyl groups and UDP-glucose:glycoprotein glucosyltransferase activity. An important paralog of this gene is UGGT1.

UniProtKB/Swiss-Prot for UGGT2 Gene

  • Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGGT2 Gene

Genomics for UGGT2 Gene

Regulatory Elements for UGGT2 Gene

Promoters for UGGT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UGGT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGGT2 Gene

Chromosome:
13
Start:
95,801,580 bp from pter
End:
96,053,482 bp from pter
Size:
251,903 bases
Orientation:
Minus strand

Genomic View for UGGT2 Gene

Genes around UGGT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGGT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGGT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGGT2 Gene

Proteins for UGGT2 Gene

  • Protein details for UGGT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYU1-UGGG2_HUMAN
    Recommended name:
    UDP-glucose:glycoprotein glucosyltransferase 2
    Protein Accession:
    Q9NYU1
    Secondary Accessions:
    • A6NKL4
    • Q08AD0
    • Q5JQR8
    • Q8N5K0
    • Q9UFC4

    Protein attributes for UGGT2 Gene

    Size:
    1516 amino acids
    Molecular mass:
    174735 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with METTL23.

    Alternative splice isoforms for UGGT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGGT2 Gene

Proteomics data for UGGT2 Gene at MOPED

Post-translational modifications for UGGT2 Gene

  • Glycosylation at Asn 256, Asn 286, Asn 920, and Asn 950
  • Modification sites at PhosphoSitePlus

Other Protein References for UGGT2 Gene

Antibody Products

Domains & Families for UGGT2 Gene

Gene Families for UGGT2 Gene

Suggested Antigen Peptide Sequences for UGGT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYU1

UniProtKB/Swiss-Prot:

UGGG2_HUMAN :
  • Belongs to the glycosyltransferase 8 family.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with UGGT2: view

Function for UGGT2 Gene

Molecular function for UGGT2 Gene

UniProtKB/Swiss-Prot Function:
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).

Enzyme Numbers (IUBMB) for UGGT2 Gene

Gene Ontology (GO) - Molecular Function for UGGT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGGT2: view
genes like me logo Genes that share phenotypes with UGGT2: view

Animal Model Products

miRNA for UGGT2 Gene

miRTarBase miRNAs that target UGGT2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGGT2 Gene

Localization for UGGT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGGT2 Gene

Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGGT2 Gene COMPARTMENTS Subcellular localization image for UGGT2 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 2
cytosol 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for UGGT2 Gene

Pathways & Interactions for UGGT2 Gene

genes like me logo Genes that share pathways with UGGT2: view

UniProtKB/Swiss-Prot Q9NYU1-UGGG2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for UGGT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
GO:1904380 endoplasmic reticulum mannose trimming TAS --
genes like me logo Genes that share ontologies with UGGT2: view

No data available for SIGNOR curated interactions for UGGT2 Gene

Drugs & Compounds for UGGT2 Gene

(5) Drugs for UGGT2 Gene - From: PharmGKB, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved Pharma Inhibition, Inhibitor 387
Caspofungin Acetate Pharma 0
Micafungin sodium Pharma Inhibitor of β-(1,3)-D-glucan synthesis;fungicide 0
Manganese Pharma 32
calcium Nutra 0

(1) Additional Compounds for UGGT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for UGGT2 Gene

Compound Action Cas Number
Caspofungin Acetate 179463-17-3
Micafungin sodium Inhibitor of β-(1,3)-D-glucan synthesis;fungicide 208538-73-2
genes like me logo Genes that share compounds with UGGT2: view

Transcripts for UGGT2 Gene

Unigene Clusters for UGGT2 Gene

UDP-glucose glycoprotein glucosyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGGT2 Gene

No ASD Table

Relevant External Links for UGGT2 Gene

GeneLoc Exon Structure for
UGGT2
ECgene alternative splicing isoforms for
UGGT2

Expression for UGGT2 Gene

mRNA expression in normal human tissues for UGGT2 Gene

Protein differential expression in normal tissues from HIPED for UGGT2 Gene

This gene is overexpressed in Testis (16.2), Fetal gut (12.0), Fetal ovary (10.5), and Heart (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGGT2 Gene



SOURCE GeneReport for Unigene cluster for UGGT2 Gene Hs.193226

mRNA Expression by UniProt/SwissProt for UGGT2 Gene

Q9NYU1-UGGG2_HUMAN
Tissue specificity: Higher levels in kidney, pancreas, heart, and skeletal muscle.
genes like me logo Genes that share expression patterns with UGGT2: view

Protein tissue co-expression partners for UGGT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UGGT2 Gene

Orthologs for UGGT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGGT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UGGT2 35
  • 88.16 (n)
  • 83.43 (a)
UGGT2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UGGT2 35
  • 89.07 (n)
  • 84.9 (a)
UGGT2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uggt2 35
  • 83.27 (n)
  • 79.26 (a)
Uggt2 16
Uggt2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UGGT2 35
  • 99.45 (n)
  • 98.81 (a)
UGGT2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563520 35
  • 80.31 (n)
  • 75.88 (a)
oppossum
(Monodelphis domestica)
Mammalia UGGT2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves UGGT2 35
  • 73.63 (n)
  • 69.69 (a)
UGGT2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UGGT2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uggt2 35
  • 68.51 (n)
  • 65.5 (a)
zebrafish
(Danio rerio)
Actinopterygii uggt2 35
  • 63.8 (n)
  • 61.65 (a)
uggt2 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ugt 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uggt-1 36
  • 41 (a)
ManyToMany
uggt-2 36
  • 36 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRE5 36
  • 19 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6797 35
barley
(Hordeum vulgare)
Liliopsida Hv.11850 35
corn
(Zea mays)
Liliopsida Zm.14120 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8102 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6415 36
  • 45 (a)
OneToMany
Species with no ortholog for UGGT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UGGT2 Gene

ENSEMBL:
Gene Tree for UGGT2 (if available)
TreeFam:
Gene Tree for UGGT2 (if available)

Paralogs for UGGT2 Gene

Paralogs for UGGT2 Gene

(2) SIMAP similar genes for UGGT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UGGT2: view

Variants for UGGT2 Gene

Sequence variations from dbSNP and Humsavar for UGGT2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs12863903 - 95,986,397(+) TGGAG(C/T)GGACA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs816142 - 95,986,382(-) ATGAT(A/G/T)CCATT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs12876018 - 95,887,950(+) CTTCA(C/G/T)GTTGA nc-transcript-variant, reference, missense
rs33949518 - 95,902,895(+) AATAG(C/T)TGTAG nc-transcript-variant, reference, missense
rs35780499 - 95,894,647(+) AATAA(A/T)GTCAC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UGGT2 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv832690 CNV Gain+Loss 17160897
nsv832691 CNV Loss 17160897
nsv527566 CNV Loss 19592680
nsv900935 CNV Loss 21882294
esv269742 CNV Insertion 20981092
nsv519575 CNV Loss 19592680
nsv1135 CNV Insertion 18451855
esv2508393 CNV Deletion 19546169
esv1995077 CNV Deletion 18987734
esv2761 CNV Deletion 18987735
esv2747850 CNV Deletion 23290073
nsv64173 CNV Loss 16902084
esv2477513 CNV Deletion 19546169
esv1008849 CNV Deletion 20482838
esv7574 CNV Loss 19470904
esv1766220 CNV Deletion 17803354
nsv900936 CNV Gain 21882294

Variation tolerance for UGGT2 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.76; 96.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGGT2 Gene

HapMap Linkage Disequilibrium report
UGGT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGGT2 Gene

Disorders for UGGT2 Gene

Relevant External Links for UGGT2

Human Genome Epidemiology (HuGE) Navigator
UGGT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGGT2

No disorders were found for UGGT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGGT2 Gene

Publications for UGGT2 Gene

  1. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. (PMID: 10694380) Arnold S.M. … Kaufman R.J. (Biochemistry 2000) 2 3 4 23 67
  2. The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain. (PMID: 12913004) Arnold S.M. … Kaufman R.J. (J. Biol. Chem. 2003) 3 23
  3. Both isoforms of human UDP-glucose:glycoprotein glucosyltransferase are enzymatically active. (PMID: 24415556) Takeda Y. … Ito Y. (Glycobiology 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3

Products for UGGT2 Gene

Sources for UGGT2 Gene

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