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UGGT2 Gene

protein-coding   GIFtS: 58
GCID: GC13M096453

UDP-Glucose Glycoprotein Glucosyltransferase 2

(Previous name: UDP-glucose ceramide glucosyltransferase-like 2)
(Previous symbol: UGCGL2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP-Glucose Glycoprotein Glucosyltransferase 21 2     UDP-Glucose Ceramide Glucosyltransferase-Like 12 3
UGCGL21 2 3     HUGT22 5
UDP-Glucose Ceramide Glucosyltransferase-Like 21 2     UDP-Glc:Glycoprotein Glucosyltransferase 22
UDP-Glucose:Glycoprotein Glucosyltransferase 21 2     EC 2.4.1.-3
UGT22 3     hUGT23
UDP--Glc:Glycoprotein Glucosyltransferase 22 3     EC 2.4.18

External Ids:    HGNC: 156641   Entrez Gene: 557572   Ensembl: ENSG000001025957   OMIM: 6058985   UniProtKB: Q9NYU13   

Export aliases for UGGT2 gene to outside databases

Previous GC identifers: GC13M095252 GC13M077051


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UGGT2 Gene:
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that
selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of
the ER.(supplied by OMIM, Oct 2009)

GeneCards Summary for UGGT2 Gene:
UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2) is a protein-coding gene. GO annotations related to this gene include UDP-glucose:glycoprotein glucosyltransferase activity. An important paralog of this gene is UGGT1.

UniProtKB/Swiss-Prot: UGGG2_HUMAN, Q9NYU1
Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded
part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum.
Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding
or degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_009952.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for UGGT2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGGT2 promoter sequence
   Search Chromatin IP Primers for UGGT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGGT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.1   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q32.1

UGGT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGGT2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M096453:  view genomic region     (about GC identifiers)

Start:
96,453,834 bp from pter      End:
96,705,736 bp from pter
Size:
251,903 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UGGG2_HUMAN, Q9NYU1 (See protein sequence)
Recommended Name: UDP-glucose:glycoprotein glucosyltransferase 2 precursor  
Size: 1516 amino acids; 174735 Da
Cofactor: Calcium or manganese
Subunit: Interacts with METTL23
Caution: Has no enzymatic activity towards unfolded RNase B or thyroglobulin (PubMed:10694380)
Secondary accessions: Q08AD0 Q5JQR8 Q9UFC4

Explore the universe of human proteins at neXtProt for UGGT2: NX_Q9NYU1

Explore proteomics data for UGGT2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn256, Asn286, Asn920, Asn950
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGGT2 (Q9NYU1) (see all 15)
     AKTIDLC  LQDLSFQ  VDTIVMA  NLDQDLPN 


    See UGGT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064506.3  
    ENSEMBL proteins: 
     ENSP00000365938   ENSP00000380743   ENSP00000365904   ENSP00000365902  
    Reactome Protein details: Q9NYU1

    UGGT2 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for UGGT2
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    Novus Biologicals UGGT2 Protein
    Novus Biologicals UGGT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UGGT2

     
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    UGGT2 Antibody Products:

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    ThermoFisher Antibodies for UGGT2
    LSBio Antibodies in human, mouse, rat for UGGT2

    UGGT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for UGGT2
    Cloud-Clone Corp. CLIAs for UGGT2
    Search eBioscience for ELISAs for UGGT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002495 Glyco_trans_8
     IPR009448 UDP-g_GGtrans

    Graphical View of Domain Structure for InterPro Entry Q9NYU1

    ProtoNet protein and cluster: Q9NYU1

    1 Blocks protein domain: IPB009448 UDP-glucose:Glycoprotein Glucosyltransferase

    UniProtKB/Swiss-Prot: UGGG2_HUMAN, Q9NYU1
    Similarity: Belongs to the glycosyltransferase 8 family


    Find genes that share domains with UGGT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UGGG2_HUMAN, Q9NYU1
    Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded
    part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum.
    Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding
    or degradation (By similarity)

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003980UDP-glucose:glycoprotein glucosyltransferase activity ISS--
    GO:0016757transferase activity, transferring glycosyl groups ----
         
    Find genes that share ontologies with UGGT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UGGT2:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGGT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGGT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGGT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGGT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target UGGT2:
    hsa-mir-1 (MIRT023666)

    Block miRNA regulation of human, mouse, rat UGGT2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate UGGT2:
    hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidUGGT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UGGT2
    Predesigned siRNA for gene silencing in human, mouse, rat UGGT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UGGT2

    Clone
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    GenScript: all cDNA clones in your preferred vector: UGGT2 (NM_020121)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGGT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGGT2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGGT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UGGG2_HUMAN, Q9NYU1: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    peroxisome2
    cytosol1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IEA--

    Find genes that share ontologies with UGGT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGGT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Calnexin/calreticulin cycle0.00
    Post-translational protein modification0.43
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.00
    Metabolism of proteins0.30
    ER Quality Control Compartment (ERQC)0.00
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with UGGT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for UGGT2
        ER Quality Control Compartment (ERQC)


    1 Kegg Pathway  (Kegg details for UGGT2):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UGGG2_HUMAN, Q9NYU1
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UGGT2: 

              Glycosylation in human mouse rat
              Unfolded Protein Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UGGT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGGT2 (Q9NYU13 ENSP000003659384) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206505P304573, ENSP000003731144I2D: score=1 STRING: ENSP00000373114
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    BREQ9NXR73, ENSP000003434124I2D: score=2 STRING: ENSP00000343412
    HLA-AP304573I2D: score=1 
    SEP15O606133, ENSP000003287294I2D: score=1 STRING: ENSP00000328729
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0006486protein glycosylation ----
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with UGGT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGGT2 (UGGG2)

    2 HMDB Compounds for UGGT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Manganesemanganese 7439-96-5--

    1 Novoseek inferred chemical compound relationship for UGGT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 82.8 1 17906960 (1)



    Find genes that share compounds with UGGT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UGGT2 gene: 
    NM_020121.3  

    Unigene Clusters for UGGT2:

    UDP-glucose glycoprotein glucosyltransferase 2
    Hs.193226  [show with all ESTs], Hs.656444  [show with all ESTs]
    Unigene Representative Sequences: NM_020121, AF339770
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376747(uc001vms.3 uc001vmt.3) ENST00000462472 ENST00000476866
    ENST00000491509 ENST00000463054(uc001vmu.1) ENST00000465196 ENST00000461329
    ENST00000467305 ENST00000397618(uc001vmv.3) ENST00000376714(uc010afo.3)
    ENST00000376712
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate UGGT2:
    hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidUGGT2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: UGGT2 (NM_020121)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGGT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGGT2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UGGT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGGT2
      QuantiTect SYBR Green Assays in human, mouse, rat UGGT2
      QuantiFast Probe-based Assays in human, mouse, rat UGGT2

    Additional mRNA sequence: AF339770.1 

    17 DOTS entries:

    DT.445178  DT.100014557  DT.431284  DT.208716  DT.97767145  DT.431285  DT.75111727  DT.120794175 
    DT.100025945  DT.120794210  DT.212930  DT.438617  DT.91676344  DT.92424457  DT.95265267  DT.97842178 
    DT.75111480 

    Selected AceView cDNA sequences (see all 98):

    AA576486 AU117642 CA866760 CA420405 AA740607 BQ775879 AA225611 Z41046 
    AI270546 AI373690 AU154660 BU073402 CB852982 AI370902 AI870568 BX645076 
    CA429559 BM975367 AA614027 CA420855 CA866494 BQ001354 BF511394 CA424229 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UGGT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGAAACC
    UGGT2 Expression
    About this image

    UGGT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGGT2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.193226 Hs.656444

    UniProtKB/Swiss-Prot: UGGG2_HUMAN, Q9NYU1
    Tissue specificity: Higher levels in kidney, pancreas, heart, and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UGGT2: 
              Glycosylation in human mouse rat
              Unfolded Protein Response in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UGGT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UGGT2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGGT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UGGT2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uggt21 , 5 UDP-glucose glycoprotein glucosyltransferase 21, 5 83.27(n)1
    79.26(a)1
      14 (62.61 cM)5
    664351  NM_001081252.21  NP_001074721.21 
     1189850395 
    chicken
    (Gallus gallus)
    Aves UGGT21 UDP-glucose glycoprotein glucosyltransferase 2 73.63(n)
    69.69(a)
      418785  NM_001252099.1  NP_001239028.1 
    lizard
    (Anolis carolinensis)
    Reptilia UGGT26
    UDP-glucose glycoprotein glucosyltransferase 2
    65(a)
    1 ↔ 1
    3(85426961-85531511)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG371289.12   -- 76.04(n)    BG371289.1 
    zebrafish
    (Danio rerio)
    Actinopterygii uggt21 UDP-glucose glycoprotein glucosyltransferase 2 63.8(n)
    61.65(a)
      497542  XM_692689.4  XP_697781.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ugt6
    UDP-glucose-glycoprotein glucosyltransferase
    39(a)
    1 → many
    3L(18865847-18871345)
    worm
    (Caenorhabditis elegans)
    Secernentea uggt-16
    uggt-26
    Protein UGGT-2 (uggt-2) mRNA, complete cds
    41(a)
    36(a)
    many ↔ many
    many ↔ many
    X(7495685-7500984) WBGene00018604
    I(9317736-9327212) WBGene00009178
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KRE56
    Protein required for beta-1,6 glucan biosynthesis;...
    19(a)
    1 → many
    XV(949773-953870) YOR336W
    soybean
    (Glycine max)
    eudicotyledons Gma.67972 Transcribed sequence with moderate similarity to protein more 75.83(n)    BU082360.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.118502 Transcribed sequence with moderate similarity to protein more 72.96(n)    BU988844.1 


    ENSEMBL Gene Tree for UGGT2 (if available)
    TreeFam Gene Tree for UGGT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGGT2 gene
    UGGT12  
    2 SIMAP similar genes for UGGT2 using alignment to 4 protein entries:     UGGG2_HUMAN (see all proteins):
    UGCGL2    UGGT1

    Find genes that share paralogs with UGGT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UGGT2 (see all 4747)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3736224321,2
    C--77268732(+) ATAGC-/GGGGGGGG 1 -- int10--------
    rs1402938831,2
    --96453403(+) CTGTCA/GCCCAG 1 -- int10--------
    rs1843146641,2
    --96453509(+) ACAGGC/TGCCCA 1 -- int10--------
    rs801553291,2
    C--96453518(+) CACCGC/TCACGC 1 -- int10--------
    rs95564991,2
    C--96453602(+) CTCAGC/GTGATC 1 -- int16Minor allele frequency- G:0.18NA WA EA 364
    rs791871131,2
    C,F--96453716(+) GTGGAT/GGCACA 1 -- int11Minor allele frequency- G:0.12WA 118
    rs1434755281,2
    C--96453982(+) CCAGAA/CTTCCC 1 -- ut310--------
    rs1896544611,2
    C--96453995(+) GCAGGC/TGGCAG 1 -- ut310--------
    rs1180485921,2
    C,F--96454001(+) GGCAGG/ATTTCC 1 -- ut312Minor allele frequency- A:0.01NA EU 1443
    rs2012754441,2
    C--96454056(+) TCATCA/GTGTGT 2 H syn10--------

    HapMap Linkage Disequilibrium report for UGGT2 (96453834 - 96703834 bp, first 250kb of UGGT2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGGT2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1008849CNV Deletion20482838
    esv2747850CNV Deletion23290073
    esv2477513CNV Deletion19546169
    esv2761CNV Deletion18987735
    esv1766220CNV Deletion17803354
    esv2508393CNV Deletion19546169
    esv1995077CNV Deletion18987734
    nsv1135CNV Insertion18451855
    esv269742CNV Insertion20981092
    nsv832691CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605898    OMIM disorders: --


    Find genes that share disorders with UGGT2           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: UGGT2 (0 documents)

    Export disorders for UGGT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGGT2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with UGGT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. (PubMed id 10694380)1, 2, 3, 9 Arnold S.M.... Kaufman R.J. (Biochemistry 2000)
    2. The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain. (PubMed id 12913004)1, 2, 9 Arnold S.M. and Kaufman R.J. (J. Biol. Chem. 2003)
    3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. (PubMed id 23097496)1 Tyler R.E....Kopito R.R. (Mol. Biol. Cell 2012)
    6. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55757 HGNC: 15664 AceView: UGCGL2 Ensembl:ENSG00000102595 euGenes: HUgn55757
    ECgene: UGGT2 Kegg: 55757 H-InvDB: UGGT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UGGT2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=UGGT2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UGGT2 gene:
    Search GeneIP for patents involving UGGT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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