Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGGT1 Gene

protein-coding   GIFtS: 60
GCID: GC02P128848

UDP-Glucose Glycoprotein Glucosyltransferase 1

(Previous name: UDP-glucose ceramide glucosyltransferase-like 1)
(Previous symbol: UGCGL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
UDP-Glucose Glycoprotein Glucosyltransferase 11 2     EC 2.4.1.-3
UGCGL11 2 3     GT3
UDP-Glucose Ceramide Glucosyltransferase-Like 11 2 3     UGGT3
UGT12 3     UGTR3
UDP--Glc:Glycoprotein Glucosyltransferase2 3     hUGT13
HUGT12 5     EC 2.4.18
UDP-Glucose:Glycoprotein Glucosyltransferase 12     

External Ids:    HGNC: 156631   Entrez Gene: 568862   Ensembl: ENSG000001367317   OMIM: 6058975   UniProtKB: Q9NYU23   
ORGUL members:         
NONCODE14:n407958      

Export aliases for UGGT1 gene to outside databases

Previous GC identifers: GC02P128566 GC02P121155


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGGT1 Gene:
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that
selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of
the ER.(supplied by OMIM, Oct 2009)

GeneCards Summary for UGGT1 Gene: 
UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with UGGT1 include dysentery, and sleeping sickness, and among its related super-pathways are WNT ligand biogenesis and trafficking and Calnexin/calreticulin cycle. GO annotations related to this gene include unfolded protein binding and UDP-glucose:glycoprotein glucosyltransferase activity. An important paralog of this gene is UGGT2.

UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2
Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded
part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum.
Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding
or degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for UGGT1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGGT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGGT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGGT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.3   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q14.3

UGGT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGGT1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P128848:  view genomic region     (about GC identifiers)

Start:
128,848,754 bp from pter      End:
128,953,251 bp from pter
Size:
104,498 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2 (See protein sequence)
Recommended Name: UDP-glucose:glycoprotein glucosyltransferase 1 precursor  
Size: 1555 amino acids; 177190 Da
Cofactor: Calcium or manganese
Subunit: Monomer as well as in a tight complex with SEP15 (By similarity)
Subcellular location: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment
Sequence caution: Sequence=AAY14885.1; Type=Erroneous gene model prediction; Sequence=BAB14632.1; Type=Erroneous
initiation;
Secondary accessions: Q53QP2 Q53SL3 Q8IW30 Q9H8I4
Alternative splicing: 2 isoforms:  Q9NYU2-1   Q9NYU2-2   

Explore the universe of human proteins at neXtProt for UGGT1: NX_Q9NYU2

Explore proteomics data for UGGT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYU2

  • 4/20 DME Specific Peptides for UGGT1 (Q9NYU2) (see all 20)
     LQDLSFQ  AKTIDLC  VDTIVMA  NLDQDLPN 

    UGGT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGGT1 Protein Expression
    REFSEQ proteins: NP_064505.1  
    ENSEMBL proteins: 
     ENSP00000400426   ENSP00000392701   ENSP00000365913   ENSP00000259253   ENSP00000389441  
     ENSP00000365158  
    Reactome Protein details: Q9NYU2
    Human Recombinant Protein Products for UGGT1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UGGT1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for UGGT1
    GenScript Custom Purified and Recombinant Proteins Services for UGGT1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UGGT1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA10694380
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment ISS--

    UGGT1 for ontologies           About GeneDecksing



    UGGT1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UGGT1
    OriGene Custom Antibody Services for UGGT1
    GenScript Custom Superior Antibodies Services for UGGT1
    Novus Biologicals UGGT1 Antibodies
    Abcam antibodies for UGGT1
    Cloud-Clone Corp. Antibodies for UGGT1 
    Search ThermoFisher Antibodies for UGGT1
    LSBio Antibodies in human, mouse, rat for UGGT1 

    Assay Products for UGGT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UGGT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UGGT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UGGT1 
    Cloud-Clone Corp. CLIAs for UGGT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009448 UDP-g_GGtrans

    Graphical View of Domain Structure for InterPro Entry Q9NYU2

    ProtoNet protein and cluster: Q9NYU2

    1 Blocks protein domain: IPB009448 UDP-glucose:Glycoprotein Glucosyltransferase

    UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2
    Domain: The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding
    defects (By similarity)
    Similarity: Belongs to the glycosyltransferase 8 family


    UGGT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UGGG1_HUMAN, Q9NYU2
    Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded
    part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum.
    Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding
    or degradation
    Induction: By tunicamycin and A23187. Induced 3-4 fold 10 hours after treatment

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003980UDP-glucose:glycoprotein glucosyltransferase activity IDA10694380
    GO:0005515protein binding ----
    GO:0051082unfolded protein binding IDA10694380
         
    UGGT1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for UGGT1:
     G0/1 arrest  Increased G1 DNA content  Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UGGT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UGGT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGGT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGGT1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UGGT1
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate UGGT1 (see all 59):
    hsa-miR-579 hsa-miR-4291 hsa-miR-361-5p hsa-miR-607 hsa-let-7d hsa-miR-624* hsa-miR-3921 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidUGGT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UGGT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGGT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UGGT1
    Sirion Biotech Customized adenovirus for overexpression of UGGT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UGGT1 (see all 9)
    OriGene ORF clones in mouse, rat for UGGT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UGGT1 (NM_020120)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGGT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGGT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UGGT1
    Search LifeMap BioReagents cell lines for UGGT1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGGT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UGGT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    2Calnexin/calreticulin cycle
    Calnexin/calreticulin cycle0.85
    ER Quality Control Compartment (ERQC)0.55
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.85
    3Signaling by GPCR
    Signal Transduction0.55
    4CFTR folding and maturation (norm and CF)
    CFTR folding and maturation (norm and CF)0.37
    5Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for UGGT1
        CFTR folding and maturation (norm and CF)

    5/9        Reactome Pathways for UGGT1 (see all 9)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle
    Signal Transduction
    Calnexin/calreticulin cycle


    1         Kegg Pathway  (Kegg details for UGGT1):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2
    Pathway: Protein modification; protein glycosylation


    UGGT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGGT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/45 Interacting proteins for UGGT1 (Q9NYU23 ENSP000002592534) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-AP304433I2D: score=1 I2D: score=1 I2D: score=1 
    ENSG00000206505P304503, ENSP000003731144I2D: score=1 I2D: score=1 STRING: ENSP00000373114
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    ENSG00000224320P304433I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0006486protein glycosylation ----
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    UGGT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGGT1 for compounds           About GeneDecksing

    EMD Millipore small molecules for UGGT1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGGT1 (UGGG1)

    2 HMDB Compounds for UGGT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Manganesemanganese 7439-96-5--

    3 Novoseek inferred chemical compound relationships for UGGT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 92.3 19 11283335 (3), 16154739 (1), 19470663 (1), 19466607 (1) (see all 15)
    polysaccharide 57.4 8 14730348 (3), 12671684 (2), 19222173 (1), 17304538 (1)
    glucose 22.5 7 12671684 (2), 19222173 (1), 12913004 (1), 14632257 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about UGGT1 / UGGG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UGGT1 gene (2 alternative transcripts): 
    NM_001025777.1  NM_020120.3  

    Unigene Cluster for UGGT1:

    UDP-glucose glycoprotein glucosyltransferase 1
    Hs.743306  [show with all ESTs]
    Unigene Representative Sequence: NR_027671
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430075 ENST00000438277(uc010fme.1) ENST00000376723 ENST00000259253
    ENST00000488439 ENST00000418197 ENST00000465836 ENST00000375990(uc002tps.3 uc002tpr.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UGGT1
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate UGGT1 (see all 59):
    hsa-miR-579 hsa-miR-4291 hsa-miR-361-5p hsa-miR-607 hsa-let-7d hsa-miR-624* hsa-miR-3921 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidUGGT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UGGT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGGT1
    Clone
    Products:
         
    OriGene clones in human, mouse for UGGT1 (see all 9)
    OriGene ORF clones in mouse, rat for UGGT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UGGT1 (NM_020120)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGGT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGGT1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UGGT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UGGT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGGT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGGT1

    Additional mRNA sequence: 

    AF227905.1 AK023240.1 AK023671.1 AK074251.1 AK074376.1 AK293066.1 AK309101.1 BC041098.1 
    BC047727.1 NR_027671.2 

    16 DOTS entries:

    DT.408761  DT.100790543  DT.422860  DT.40279255  DT.105982  DT.95156634  DT.101974259  DT.92008224 
    DT.100737979  DT.120984571  DT.305778  DT.91742067  DT.92002021  DT.92427719  DT.95155165  DT.95265020 

    24/182 AceView cDNA sequences (see all 182):

    NM_020120 BC041098 AI655867 BM040793 AF227905 AI080983 BX475218 AA847178 
    BP359091 BE550513 BF592808 BQ932226 CB215567 CB152902 BQ945763 AI696951 
    BP364560 AW002565 AA926726 AW135426 AI655525 CD106217 AA279123 AA810550 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UGGT1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                                      -                                                                                                     -               
    SP2:                          -           -                                                                                                     -               
    SP3:                                                                                                                                                            
    SP4:                    -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41a · 41b · 41c · 41d ^
    SP1:                                                        -                                                                                               -   
    SP2:                                                        -                                                                                               -   
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:        -                                                                                                                                                   

    ExUns: 42a · 42b ^ 43a · 43b · 43c
    SP1:  -                           
    SP2:  -                           
    SP3:  -                           
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for UGGT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGGT1 expression in normal human tissues (normalized intensities)      UGGT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCCAACC
    UGGT1 Expression
    About this image


    UGGT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
             endometrial endothelial cell   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See UGGT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGGT1

    SOURCE GeneReport for Unigene cluster: Hs.743306

    UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2
    Tissue specificity: Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including UGGT1: 
              Glycosylation in human mouse rat
              Unfolded Protein Response in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UGGT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UGGT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGGT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGGT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGGT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UGGT1 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uggt11 , 5 UDP-glucose glycoprotein glucosyltransferase 11, 5 86.72(n)1
    90.91(a)1
      1 (15.15 cM)5
    3200111  NM_198899.21  NP_942602.21 
     361415305 
    chicken
    (Gallus gallus)
    Aves UGGT11 UDP-glucose glycoprotein glucosyltransferase 1 78.49(n)
    85.84(a)
      424757  XM_422579.3  XP_422579.3 
    lizard
    (Anolis carolinensis)
    Reptilia UGGT16
    UDP-glucose glycoprotein glucosyltransferase 1
    85(a)
    1 ↔ 1
    3(36411431-36469479)
    zebrafish
    (Danio rerio)
    Actinopterygii BG304166.12   -- 79.58(n)    BG304166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ugt1 UDP-glucose-glycoprotein glucosyltransferase 51.17(n)
    45.75(a)
      40055  NM_079427.2  NP_524151.2 
    worm
    (Caenorhabditis elegans)
    Secernentea uggt-16
    uggt-26
    Protein UGGT-2
    42(a)
    37(a)
    many ↔ many
    many ↔ many
    X(7495685-7500984)
    I(9317736-9327212)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KRE5(YOR336W)4 Protein required for beta-1,6 glucan biosynthesis; more   --   15(949773-953870) 854514  NP_014981.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EBS11 UDP-glucose:glycoprotein glucosyltransferase 48.32(n)
    39.22(a)
      843462  NM_105791.4  NP_177278.3 
    rice
    (Oryza sativa)
    Liliopsida Os.59002 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.73(n)    AK059298.1 


    ENSEMBL Gene Tree for UGGT1 (if available)
    TreeFam Gene Tree for UGGT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGGT1 gene
    UGGT22  
    1 SIMAP similar gene for UGGT1 using alignment to 6 protein entries:     UGGG1_HUMAN (see all proteins):
    UGGT2

    UGGT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2413 SNPs in UGGT1 are shown (see all 2413)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1509432351,2
    --121153067(+) TTATTA/GTAACA 1 -- us2k10--------
    rs1407506531,2
    --121153128(+) CCAGTA/GAAACA 1 -- us2k10--------
    rs590018851,2
    C--121172455(+) AGACA-/GTCA  
            
    AAGAT
    2 -- int11Minor allele frequency- GTCA:0.00NA 2
    rs1432787921,2
    --128846821(+) TTCCAA/CATAAG 2 -- us2k10--------
    rs1161908551,2
    C,F--128846826(+) AATAAG/TATCCT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1466851731,2
    C--128846916(+) TAAACG/TGCAAG 2 -- us2k10--------
    rs1817160191,2
    C--128846921(+) TGCAAA/GGATGT 2 -- us2k10--------
    rs1150773091,2
    C,F--128846952(+) ACATGC/ACAAAG 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs344666231,2
    C,F--128847046(+) TTTTTT/-CTTTT 2 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs1839575711,2
    C--128847113(+) CATATG/TCACAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UGGT1 (128848754 - 128953251 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for UGGT1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2538670CNV Deletion19546169
    esv2187638CNV Deletion18987734
    esv2459834CNV Deletion19546169
    esv998959CNV Deletion20482838
    esv2720736CNV Deletion23290073
    esv3599CNV Deletion18987735
    esv1434860CNV Deletion17803354
    esv2656463CNV Deletion23128226
    nsv819034CNV Loss19587683
    esv275386CNV Loss21479260

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UGGT1
    DNA2.0 Custom Variant and Variant Library Synthesis for UGGT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605897    OMIM disorders: --

    3 diseases for UGGT1:    About MalaCards
    dysentery    sleeping sickness    hepatitis


    UGGT1 for disorders           About GeneDecksing


    Export disorders for UGGT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGGT1 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with UGGT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. (PubMed id 10694380)1, 2, 3, 9 Arnold S.M.... Kaufman R.J. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain. (PubMed id 12913004)1, 9 Arnold S.M. and Kaufman R.J. (2003)
    5. The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin. (PubMed id 20498017)1, 9 Pearse B.R....Hebert D.N. (2010)
    6. Identification of HUGT1 as a potential BiP activator and a cellular target for improvement of recombinant protein production using a cDNA screening system. (PubMed id 19466607)1, 9 Ku S.C....Chao S.H. (2009)
    7. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)1 Haines D.S....Deshaies R.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56886 HGNC: 15663 AceView: UGCGL1 Ensembl:ENSG00000136731 euGenes: HUgn56886
    ECgene: UGGT1 Kegg: 56886 H-InvDB: UGGT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGGT1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGGT1 gene:
    Search GeneIP for patents involving UGGT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore small molecules (inhibitor) for UGGT1
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UGGT1   OriGene RNAi products in human, mouse, rat for UGGT1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UGGT1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UGGT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UGGT1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UGGT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UGGT1   OriGene Custom Protein Services for UGGT1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UGGT1
     QIAGEN SeqTarget long-range PCR primers for resequencing UGGT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGGT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGGT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGGT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGGT1
     GenScript Custom Purified and Recombinant Proteins Services for UGGT1 GenScript cDNA clones with any tag delivered in your preferred vector for UGGT1
     GenScript Custom Assay Services for UGGT1 GenScript Custom Superior Antibodies Services for UGGT1
     GenScript Custom overexpressing Cell Line Services for UGGT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for UGGT1
     Search Chromatin IP Primers for UGGT1
     RT2 qPCR Primer Assay in human, mouse, rat UGGT1
     Search GNC Networks for UGGT1
     SABiosciences PCR Arrays including human, mouse, rat UGGT1
     Search Tocris compounds for UGGT1 (UGGG1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UGGT1 antibodies
     Antibodies for UGGT1
     See all of Abcam's Antibodies, Kits and Proteins for UGGT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UGGT1
     Antibodies for UGGT1
     ELISAs for UGGT1
     CLIAs for UGGT1
     Search LifeMap BioReagents cell lines for UGGT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGGT1
     SwitchGear 3'UTR luciferase reporter plasmids for UGGT1
     SwitchGear Promoter luciferase reporter plasmids for UGGT1
     Search ThermoFisher Antibodies for UGGT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGGT1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UGGT1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UGGT1
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of UGGT1
     LSBio Antibodies in human, mouse, rat for UGGT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UGGT1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4