Aliases for UGGT1 Gene
External Ids for UGGT1 Gene
Previous Symbols for UGGT1 Gene
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
GeneCards Summary for UGGT1 Gene
UGGT1 (UDP-Glucose Glycoprotein Glucosyltransferase 1) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include unfolded protein binding and UDP-glucose:glycoprotein glucosyltransferase activity. An important paralog of this gene is UGGT2.
UniProtKB/Swiss-Prot for UGGT1 Gene
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.