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Aliases for UGGT1 Gene

Aliases for UGGT1 Gene

  • UDP-Glucose Glycoprotein Glucosyltransferase 1 2 3 5
  • UDP-Glucose Ceramide Glucosyltransferase-Like 1 2 3 4
  • UDP--Glc:Glycoprotein Glucosyltransferase 3 4
  • UGCGL1 3 4
  • HUGT1 3 4
  • UGT1 3 4
  • EC 2.4.1.- 4
  • EC 2.4.1 63
  • UGGT 4
  • UGTR 4
  • GT 4

External Ids for UGGT1 Gene

Previous HGNC Symbols for UGGT1 Gene

  • UGCGL1

Previous GeneCards Identifiers for UGGT1 Gene

  • GC02P128566
  • GC02P128848
  • GC02P121155

Summaries for UGGT1 Gene

Entrez Gene Summary for UGGT1 Gene

  • UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]

GeneCards Summary for UGGT1 Gene

UGGT1 (UDP-Glucose Glycoprotein Glucosyltransferase 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include unfolded protein binding and UDP-glucose:glycoprotein glucosyltransferase activity. An important paralog of this gene is UGGT2.

UniProtKB/Swiss-Prot for UGGT1 Gene

  • Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGGT1 Gene

Genomics for UGGT1 Gene

Regulatory Elements for UGGT1 Gene

Promoters for UGGT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UGGT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGGT1 Gene

Chromosome:
2
Start:
128,091,180 bp from pter
End:
128,195,677 bp from pter
Size:
104,498 bases
Orientation:
Plus strand

Genomic View for UGGT1 Gene

Genes around UGGT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGGT1 Gene

Proteins for UGGT1 Gene

  • Protein details for UGGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYU2-UGGG1_HUMAN
    Recommended name:
    UDP-glucose:glycoprotein glucosyltransferase 1
    Protein Accession:
    Q9NYU2
    Secondary Accessions:
    • Q53QP2
    • Q53SL3
    • Q8IW30
    • Q9H8I4

    Protein attributes for UGGT1 Gene

    Size:
    1555 amino acids
    Molecular mass:
    177190 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer as well as in a tight complex with SEP15 (By similarity). Interacts with METTL23.
    SequenceCaution:
    • Sequence=AAY14885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14632.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UGGT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGGT1 Gene

Proteomics data for UGGT1 Gene at MOPED

Post-translational modifications for UGGT1 Gene

  • Glycosylation at Asn 269, Asn 536, Asn 1228, and Thr 1241
  • Modification sites at PhosphoSitePlus

Other Protein References for UGGT1 Gene

Antibody Products

Domains & Families for UGGT1 Gene

Gene Families for UGGT1 Gene

Protein Domains for UGGT1 Gene

Suggested Antigen Peptide Sequences for UGGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYU2

UniProtKB/Swiss-Prot:

UGGG1_HUMAN :
  • The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
  • Belongs to the glycosyltransferase 8 family.
Domain:
  • The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with UGGT1: view

Function for UGGT1 Gene

Molecular function for UGGT1 Gene

UniProtKB/Swiss-Prot Function:
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
UniProtKB/Swiss-Prot Induction:
By tunicamycin and A23187. Induced 3-4 fold 10 hours after treatment.

Enzyme Numbers (IUBMB) for UGGT1 Gene

genes like me logo Genes that share phenotypes with UGGT1: view

Animal Model Products

CRISPR Products

miRNA for UGGT1 Gene

miRTarBase miRNAs that target UGGT1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGGT1 Gene

Localization for UGGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGGT1 Gene

Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGGT1 Gene COMPARTMENTS Subcellular localization image for UGGT1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 3
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for UGGT1 Gene

Pathways & Interactions for UGGT1 Gene

genes like me logo Genes that share pathways with UGGT1: view

UniProtKB/Swiss-Prot Q9NYU2-UGGG1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for UGGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
GO:0051084 de novo posttranslational protein folding TAS 10694380
GO:1904380 endoplasmic reticulum mannose trimming TAS --
genes like me logo Genes that share ontologies with UGGT1: view

No data available for SIGNOR curated interactions for UGGT1 Gene

Drugs & Compounds for UGGT1 Gene

(4) Drugs for UGGT1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caspofungin Acetate Pharma 0
Micafungin sodium Pharma Inhibitor of β-(1,3)-D-glucan synthesis;fungicide 0
Manganese Pharma 32
calcium Nutra 0

(3) Additional Compounds for UGGT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UGGT1: view

Transcripts for UGGT1 Gene

Unigene Clusters for UGGT1 Gene

UDP-glucose glycoprotein glucosyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGGT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - -
SP2: - - -
SP3:
SP4: - -
SP5:
SP6: - - - - - -
SP7:
SP8:
SP9:

ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41a · 41b · 41c · 41d ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: -
SP6:
SP7: -
SP8:
SP9:

ExUns: 42a · 42b ^ 43a · 43b · 43c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for UGGT1 Gene

GeneLoc Exon Structure for
UGGT1
ECgene alternative splicing isoforms for
UGGT1

Expression for UGGT1 Gene

mRNA expression in normal human tissues for UGGT1 Gene

Protein differential expression in normal tissues from HIPED for UGGT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.8) and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGGT1 Gene



SOURCE GeneReport for Unigene cluster for UGGT1 Gene Hs.743306

mRNA Expression by UniProt/SwissProt for UGGT1 Gene

Q9NYU2-UGGG1_HUMAN
Tissue specificity: Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.
genes like me logo Genes that share expression patterns with UGGT1: view

Protein tissue co-expression partners for UGGT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UGGT1 Gene

Orthologs for UGGT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGGT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGGT1 35
  • 99.72 (n)
  • 99.68 (a)
UGGT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGGT1 36
  • 94 (a)
OneToOne
UGGT1 35
  • 91.23 (n)
  • 94.66 (a)
dog
(Canis familiaris)
Mammalia UGGT1 35
  • 92.42 (n)
  • 95.56 (a)
UGGT1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uggt1 16
Uggt1 35
  • 86.72 (n)
  • 90.91 (a)
Uggt1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UGGT1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UGGT1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uggt1 35
  • 87.51 (n)
  • 92.34 (a)
chicken
(Gallus gallus)
Aves UGGT1 36
  • 85 (a)
OneToOne
UGGT1 35
  • 78.13 (n)
  • 85.15 (a)
lizard
(Anolis carolinensis)
Reptilia UGGT1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uggt1 35
  • 71.19 (n)
  • 76.41 (a)
zebrafish
(Danio rerio)
Actinopterygii uggt1 35
  • 71.49 (n)
  • 76.99 (a)
uggt1 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003560 35
  • 51.92 (n)
  • 47.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ugt 35
  • 50.99 (n)
  • 45.75 (a)
Ugt 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uggt-1 36
  • 42 (a)
ManyToMany
uggt-2 36
  • 37 (a)
ManyToMany
uggt-1 35
  • 51.57 (n)
  • 44.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRE5 36
  • 21 (a)
OneToMany
KRE5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EBS1 35
  • 48.23 (n)
  • 39.7 (a)
rice
(Oryza sativa)
Liliopsida Os.5900 35
wheat
(Triticum aestivum)
Liliopsida Ta.29390 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02349 35
  • 46.18 (n)
  • 36.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpt1 35
  • 46.02 (n)
  • 36.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6415 36
  • 48 (a)
OneToMany
Species with no ortholog for UGGT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UGGT1 Gene

ENSEMBL:
Gene Tree for UGGT1 (if available)
TreeFam:
Gene Tree for UGGT1 (if available)

Paralogs for UGGT1 Gene

Paralogs for UGGT1 Gene

(1) SIMAP similar genes for UGGT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UGGT1: view

Variants for UGGT1 Gene

Sequence variations from dbSNP and Humsavar for UGGT1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1054317 -- 128,192,319(+) TAACC(A/G)AATGC nc-transcript-variant, utr-variant-3-prime
rs2122115 -- 128,164,421(-) CCCTT(C/G)TCCTT intron-variant
rs2276565 -- 128,170,717(-) GAAAA(A/C)TGAAA intron-variant
rs4497826 -- 128,114,854(+) CTCTG(A/G)ATTGA intron-variant
rs4569417 -- 128,107,198(+) TTTCT(A/C)CTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGGT1 Gene

Variant ID Type Subtype PubMed ID
nsv470484 CNV Gain 18288195
esv2538670 CNV Deletion 19546169
esv2187638 CNV Deletion 18987734
esv2720736 CNV Deletion 23290073
esv3599 CNV Deletion 18987735
esv2459834 CNV Deletion 19546169
esv998959 CNV Deletion 20482838
esv1434860 CNV Deletion 17803354
esv7010 CNV Loss 19470904
esv275386 CNV Loss 21479260
esv2656463 CNV Deletion 23128226
nsv819034 CNV Loss 19587683
nsv7326 OTHER Inversion 18451855
nsv875034 CNV Loss 21882294

Variation tolerance for UGGT1 Gene

Residual Variation Intolerance Score: 1.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGGT1 Gene

HapMap Linkage Disequilibrium report
UGGT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGGT1 Gene

Disorders for UGGT1 Gene

Relevant External Links for UGGT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGGT1

No disorders were found for UGGT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGGT1 Gene

Publications for UGGT1 Gene

  1. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. (PMID: 10694380) Arnold S.M. … Kaufman R.J. (Biochemistry 2000) 2 3 4 23 67
  2. The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin. (PMID: 20498017) Pearse B.R. … Hebert D.N. (J. Cell Biol. 2010) 3 23
  3. Identification of HUGT1 as a potential BiP activator and a cellular target for improvement of recombinant protein production using a cDNA screening system. (PMID: 19466607) Ku S.C. … Chao S.H. (Mol. Cells 2009) 3 23
  4. The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain. (PMID: 12913004) Arnold S.M. … Kaufman R.J. (J. Biol. Chem. 2003) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for UGGT1 Gene

Sources for UGGT1 Gene

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