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Aliases for UGGT1 Gene

Aliases for UGGT1 Gene

  • UDP-Glucose Glycoprotein Glucosyltransferase 1 2 3 5
  • UDP-Glucose Ceramide Glucosyltransferase-Like 1 2 3 4
  • UDP--Glc:Glycoprotein Glucosyltransferase 3 4
  • UGCGL1 3 4
  • HUGT1 3 4
  • UGT1 3 4
  • UDP-Glucose:Glycoprotein Glucosyltransferase 1 3
  • EC 2.4.1.- 4
  • EC 2.4.1 58
  • UGGT 4
  • UGTR 4
  • GT 4

External Ids for UGGT1 Gene

Previous HGNC Symbols for UGGT1 Gene

  • UGCGL1

Previous GeneCards Identifiers for UGGT1 Gene

  • GC02P128566
  • GC02P128848
  • GC02P121155

Summaries for UGGT1 Gene

Entrez Gene Summary for UGGT1 Gene

  • UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]

GeneCards Summary for UGGT1 Gene

UGGT1 (UDP-Glucose Glycoprotein Glucosyltransferase 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Transport to the Golgi and subsequent modification. GO annotations related to this gene include unfolded protein binding and UDP-glucose:glycoprotein glucosyltransferase activity. An important paralog of this gene is UGGT2.

UniProtKB/Swiss-Prot for UGGT1 Gene

  • Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.

Additional gene information for UGGT1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGGT1 Gene

Genomics for UGGT1 Gene

Regulatory Elements for UGGT1 Gene

Enhancers for UGGT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H128166 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14 +78.0 77951 4 FOXA2 ATF1 MLX ARID4B DMAP1 SLC30A9 SP5 MXD4 NFYC MIER2 UGGT1 GC02M128109 GC02P128200 DYNLT3P2
GH02H128299 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +214.3 214275 12 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 WDR33 AMMECR1L MAP3K2 UGGT1 ENSG00000231731 HS6ST1 GPR17 GC02M128248
GH02H128194 1.4 Ensembl ENCODE dbSUPER 13.1 +104.9 104885 2 ELF3 TBP FOXA2 ATF1 ARID4B DMAP1 RAD21 ZSCAN9 RARA RCOR1 UGGT1 GC02P128200 DYNLT3P2 GC02M128109
GH02H128177 1.2 ENCODE dbSUPER 14.2 +88.3 88308 3 FOXA2 ATF1 MLX ARID4B ZNF143 FOS ATF7 SP5 ZHX2 REST UGGT1 GC02P128200 GC02M128109 DYNLT3P2
GH02H128321 1.5 Ensembl ENCODE dbSUPER 11.1 +231.1 231110 2 ATF1 ARID4B SIN3A DMAP1 GTF3C2 ZNF143 ZNF207 ATF7 RUNX3 SP3 AMMECR1L WDR33 MAP3K2 UGGT1 HS6ST1 GC02M128305
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UGGT1 on UCSC Golden Path with GeneCards custom track

Promoters for UGGT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122940 220 2401 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for UGGT1 Gene

Chromosome:
2
Start:
128,091,180 bp from pter
End:
128,195,677 bp from pter
Size:
104,498 bases
Orientation:
Plus strand

Genomic View for UGGT1 Gene

Genes around UGGT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGGT1 Gene

Proteins for UGGT1 Gene

  • Protein details for UGGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYU2-UGGG1_HUMAN
    Recommended name:
    UDP-glucose:glycoprotein glucosyltransferase 1
    Protein Accession:
    Q9NYU2
    Secondary Accessions:
    • Q53QP2
    • Q53SL3
    • Q8IW30
    • Q9H8I4

    Protein attributes for UGGT1 Gene

    Size:
    1555 amino acids
    Molecular mass:
    177190 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer as well as in a tight complex with SELENOF (By similarity). Interacts with METTL23.
    SequenceCaution:
    • Sequence=AAY14885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14632.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UGGT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGGT1 Gene

Selected DME Specific Peptides for UGGT1 Gene

Q9NYU2:
  • LEYLLLEGHC
  • AKTIDLC
  • YKILFLDVLFPL
  • RFWKSGYW
  • FRKIAAGDRLRGQYQ
  • LKNYLSPTFKE
  • YHISALYVVDL
  • NLDQDLPN
  • LQDLSFQ
  • EVQGFLFGKL
  • LLRPTFPG
  • NIFSVASGHLYERFLRIMMLSVL
  • VDADQIVR
  • VDTIVMA
  • KFWFLKNYLSP
  • AEYELEYLLLEG
  • LDGAPYGYTPFCDSRREMDGYRFWK
  • WLWCETWC
  • QPPRGLQFTLGT
  • NTKTPVKFW

Post-translational modifications for UGGT1 Gene

  • Glycosylation at posLast=269269, Asn536, Asn1228, and posLast=12411241
  • Modification sites at PhosphoSitePlus

Domains & Families for UGGT1 Gene

Gene Families for UGGT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for UGGT1 Gene

Suggested Antigen Peptide Sequences for UGGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYU2

UniProtKB/Swiss-Prot:

UGGG1_HUMAN :
  • The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
  • Belongs to the glycosyltransferase 8 family.
Domain:
  • The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with UGGT1: view

Function for UGGT1 Gene

Molecular function for UGGT1 Gene

UniProtKB/Swiss-Prot Function:
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
UniProtKB/Swiss-Prot Induction:
By tunicamycin and A23187. Induced 3-4 fold 10 hours after treatment.

Enzyme Numbers (IUBMB) for UGGT1 Gene

Gene Ontology (GO) - Molecular Function for UGGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity TAS --
GO:0005515 protein binding IPI 23349634
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0051082 unfolded protein binding IDA,IEA 10694380
genes like me logo Genes that share ontologies with UGGT1: view
genes like me logo Genes that share phenotypes with UGGT1: view

Animal Model Products

CRISPR Products

miRNA for UGGT1 Gene

miRTarBase miRNAs that target UGGT1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UGGT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGGT1 Gene

Localization for UGGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGGT1 Gene

Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGGT1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UGGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 10694380
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISS --
GO:0043234 protein complex IDA 23349634
GO:0044322 endoplasmic reticulum quality control compartment IEA --
genes like me logo Genes that share ontologies with UGGT1: view

Pathways & Interactions for UGGT1 Gene

genes like me logo Genes that share pathways with UGGT1: view

UniProtKB/Swiss-Prot Q9NYU2-UGGG1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for UGGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0018279 protein N-linked glycosylation via asparagine IBA --
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
GO:0051084 de novo posttranslational protein folding TAS 10694380
GO:0071712 ER-associated misfolded protein catabolic process IBA --
genes like me logo Genes that share ontologies with UGGT1: view

No data available for SIGNOR curated interactions for UGGT1 Gene

Drugs & Compounds for UGGT1 Gene

(5) Drugs for UGGT1 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
Caspofungin Acetate Pharma 0
Micafungin sodium Pharma Inhibitor of β-(1,3)-D-glucan synthesis;fungicide 0
calcium Nutra 0

(2) Additional Compounds for UGGT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for UGGT1 Gene

Compound Action Cas Number
Caspofungin Acetate 179463-17-3
Micafungin sodium Inhibitor of β-(1,3)-D-glucan synthesis;fungicide 208538-73-2
genes like me logo Genes that share compounds with UGGT1: view

Drug Products

Transcripts for UGGT1 Gene

Unigene Clusters for UGGT1 Gene

UDP-glucose glycoprotein glucosyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UGGT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UGGT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - -
SP2: - - -
SP3:
SP4: - -
SP5:
SP6: - - - - - -
SP7:
SP8:
SP9:

ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41a · 41b · 41c · 41d ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: -
SP6:
SP7: -
SP8:
SP9:

ExUns: 42a · 42b ^ 43a · 43b · 43c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for UGGT1 Gene

GeneLoc Exon Structure for
UGGT1
ECgene alternative splicing isoforms for
UGGT1

Expression for UGGT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGGT1 Gene

Protein differential expression in normal tissues from HIPED for UGGT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.8) and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGGT1 Gene



Protein tissue co-expression partners for UGGT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UGGT1 Gene:

UGGT1

SOURCE GeneReport for Unigene cluster for UGGT1 Gene:

Hs.743306

mRNA Expression by UniProt/SwissProt for UGGT1 Gene:

Q9NYU2-UGGG1_HUMAN
Tissue specificity: Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.

Evidence on tissue expression from TISSUES for UGGT1 Gene

  • Liver(4.7)
  • Adrenal gland(2.6)
  • Eye(2.6)
  • Heart(2.6)
  • Blood(2.5)
  • Pancreas(2.5)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with UGGT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGGT1 Gene

Orthologs for UGGT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGGT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGGT1 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia UGGT1 33 34
  • 92.42 (n)
cow
(Bos Taurus)
Mammalia UGGT1 33 34
  • 91.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UGGT1 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uggt1 33
  • 87.51 (n)
oppossum
(Monodelphis domestica)
Mammalia UGGT1 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uggt1 33 16 34
  • 86.72 (n)
chicken
(Gallus gallus)
Aves UGGT1 33 34
  • 78.13 (n)
lizard
(Anolis carolinensis)
Reptilia UGGT1 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uggt1 33
  • 71.19 (n)
zebrafish
(Danio rerio)
Actinopterygii uggt1 33 34
  • 71.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003560 33
  • 51.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ugt 33 34
  • 50.99 (n)
worm
(Caenorhabditis elegans)
Secernentea uggt-1 33 34
  • 51.57 (n)
uggt-2 34
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRE5 34 36
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EBS1 33
  • 48.23 (n)
rice
(Oryza sativa)
Liliopsida Os.5900 33
wheat
(Triticum aestivum)
Liliopsida Ta.29390 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6415 34
  • 48 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02349 33
  • 46.18 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpt1 33
  • 46.02 (n)
Species where no ortholog for UGGT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UGGT1 Gene

ENSEMBL:
Gene Tree for UGGT1 (if available)
TreeFam:
Gene Tree for UGGT1 (if available)

Paralogs for UGGT1 Gene

Paralogs for UGGT1 Gene

(1) SIMAP similar genes for UGGT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UGGT1: view

Variants for UGGT1 Gene

Sequence variations from dbSNP and Humsavar for UGGT1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000043206 -- 128,159,316(+) GGCTG(G/T)TCTCG intron-variant
rs1000048036 -- 128,188,809(+) AGACC(C/T)TGTCT intron-variant
rs1000065762 -- 128,097,759(+) TATGT(A/G)GGTTT intron-variant
rs1000075834 -- 128,159,167(+) TGATC(C/T)TGGCT intron-variant
rs1000078811 -- 128,117,796(+) CGCCC(A/G/T)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGGT1 Gene

Variant ID Type Subtype PubMed ID
dgv2028n106 CNV deletion 24896259
esv1434860 CNV deletion 17803354
esv2187638 CNV deletion 18987734
esv2459834 CNV deletion 19546169
esv2538670 CNV deletion 19546169
esv2656463 CNV deletion 23128226
esv2720736 CNV deletion 23290073
esv275386 CNV loss 21479260
esv3560108 CNV deletion 23714750
esv3560109 CNV deletion 23714750
esv3592378 CNV loss 21293372
esv3592380 CNV gain 21293372
esv3599 CNV loss 18987735
esv7010 CNV loss 19470904
esv998959 CNV deletion 20482838
nsv1005201 CNV loss 25217958
nsv1072448 CNV deletion 25765185
nsv1142971 CNV tandem duplication 24896259
nsv470484 CNV gain 18288195
nsv7326 OTHER inversion 18451855
nsv819034 CNV loss 19587683
nsv954174 CNV deletion 24416366

Variation tolerance for UGGT1 Gene

Residual Variation Intolerance Score: 1.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGGT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGGT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGGT1 Gene

Disorders for UGGT1 Gene

Relevant External Links for UGGT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGGT1

No disorders were found for UGGT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGGT1 Gene

Publications for UGGT1 Gene

  1. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. (PMID: 10694380) Arnold SM … Kaufman RJ (Biochemistry 2000) 2 3 4 22 60
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 60
  3. The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin. (PMID: 20498017) Pearse BR … Hebert DN (The Journal of cell biology 2010) 3 22 60
  4. Identification of HUGT1 as a potential BiP activator and a cellular target for improvement of recombinant protein production using a cDNA screening system. (PMID: 19466607) Ku SC … Chao SH (Molecules and cells 2009) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for UGGT1 Gene

Sources for UGGT1 Gene

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