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UGGT1 Gene

protein-coding   GIFtS: 57
GCID: GC02P128848

UDP-Glucose Glycoprotein Glucosyltransferase 1

(Previous name: UDP-glucose ceramide glucosyltransferase-like 1)
(Previous symbol: UGCGL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP-Glucose Glycoprotein Glucosyltransferase 11 2     EC 2.4.1.-3
UGCGL11 2 3     GT3
UDP-Glucose Ceramide Glucosyltransferase-Like 11 2 3     UGGT3
UGT12 3     UGTR3
UDP--Glc:Glycoprotein Glucosyltransferase2 3     hUGT13
HUGT12 5     EC 2.4.18
UDP-Glucose:Glycoprotein Glucosyltransferase 12     

External Ids:    HGNC: 156631   Entrez Gene: 568862   Ensembl: ENSG000001367317   OMIM: 6058975   UniProtKB: Q9NYU23   

Export aliases for UGGT1 gene to outside databases

Previous GC identifers: GC02P128566 GC02P121155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UGGT1 Gene:
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that
selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of
the ER.(supplied by OMIM, Oct 2009)

GeneCards Summary for UGGT1 Gene:
UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) is a protein-coding gene. Diseases associated with UGGT1 include dysentery, and sleeping sickness. GO annotations related to this gene include unfolded protein binding and UDP-glucose:glycoprotein glucosyltransferase activity. An important paralog of this gene is UGGT2.

UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2
Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded
part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum.
Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding
or degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for UGGT1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGGT1 promoter sequence
   Search Chromatin IP Primers for UGGT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGGT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.3   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q14.3

UGGT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGGT1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P128848:  view genomic region     (about GC identifiers)

Start:
128,848,754 bp from pter      End:
128,953,251 bp from pter
Size:
104,498 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2 (See protein sequence)
Recommended Name: UDP-glucose:glycoprotein glucosyltransferase 1 precursor  
Size: 1555 amino acids; 177190 Da
Cofactor: Calcium or manganese
Subunit: Monomer as well as in a tight complex with SEP15 (By similarity). Interacts with METTL23
Sequence caution: Sequence=AAY14885.1; Type=Erroneous gene model prediction; Sequence=BAB14632.1; Type=Erroneous
initiation;
Secondary accessions: Q53QP2 Q53SL3 Q8IW30 Q9H8I4
Alternative splicing: 2 isoforms:  Q9NYU2-1   Q9NYU2-2   

Explore the universe of human proteins at neXtProt for UGGT1: NX_Q9NYU2

Explore proteomics data for UGGT1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn269, Asn536, Asn1228, Thr1241
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGGT1 (Q9NYU2) (see all 20)
     LQDLSFQ  AKTIDLC  VDTIVMA  NLDQDLPN 


    See UGGT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064505.1  
    ENSEMBL proteins: 
     ENSP00000400426   ENSP00000392701   ENSP00000365913   ENSP00000259253   ENSP00000389441  
     ENSP00000365158  
    Reactome Protein details: Q9NYU2

    UGGT1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for UGGT1
    OriGene Custom MassSpec
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for UGGT1

    UGGT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals UGGT1 Antibodies
    Abcam antibodies for UGGT1
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    Search ThermoFisher Antibodies for UGGT1
    LSBio Antibodies in human, mouse, rat for UGGT1

    UGGT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for UGGT1
    Cloud-Clone Corp. CLIAs for UGGT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009448 UDP-g_GGtrans

    Graphical View of Domain Structure for InterPro Entry Q9NYU2

    ProtoNet protein and cluster: Q9NYU2

    1 Blocks protein domain: IPB009448 UDP-glucose:Glycoprotein Glucosyltransferase

    UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2
    Domain: The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding
    defects (By similarity)
    Similarity: Belongs to the glycosyltransferase 8 family


    UGGT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UGGG1_HUMAN, Q9NYU2
    Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded
    part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum.
    Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding
    or degradation
    Induction: By tunicamycin and A23187. Induced 3-4 fold 10 hours after treatment

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003980UDP-glucose:glycoprotein glucosyltransferase activity IDA10694380
    GO:0005515protein binding ----
    GO:0051082unfolded protein binding IDA10694380
         
    UGGT1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for UGGT1:
     G0/1 arrest  Increased G1 DNA content  Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGGT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGGT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGGT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGGT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UGGT1:
    hsa-mir-21-5p (MIRT031020), hsa-mir-1 (MIRT024006), hsa-let-7e-5p (MIRT051507), hsa-mir-1254 (MIRT035857), hsa-mir-615-3p (MIRT040381), hsa-mir-335-5p (MIRT018913)

    Block miRNA regulation of human, mouse, rat UGGT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UGGT1 (see all 59):
    hsa-miR-579 hsa-miR-4291 hsa-miR-361-5p hsa-miR-607 hsa-let-7d hsa-miR-624* hsa-miR-3921 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidUGGT1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat UGGT1

    Gene Editing
    Products:
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    GenScript: all cDNA clones in your preferred vector: UGGT1 (NM_020120)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGGT1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGGT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UGGG1_HUMAN, Q9NYU2: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    golgi apparatus2
    cytoskeleton1
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA10694380
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment ISS--
    GO:0070062extracellular vesicular exosome IDA19199708

    UGGT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGGT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Calnexin/calreticulin cycle0.00
    Post-translational protein modification0.43
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.00
    Metabolism of proteins0.30
    ER Quality Control Compartment (ERQC)0.00
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for UGGT1
        CFTR folding and maturation (norm and CF)

    1 Reactome Pathway for UGGT1
        ER Quality Control Compartment (ERQC)


    1 Kegg Pathway  (Kegg details for UGGT1):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2
    Pathway: Protein modification; protein glycosylation


    UGGT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UGGT1: 

              Glycosylation in human mouse rat
              Unfolded Protein Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UGGT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGGT1 (Q9NYU23 ENSP000002592534) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-AP304433I2D: score=1 I2D: score=1 I2D: score=1 
    ENSG00000206505P304503, ENSP000003731144I2D: score=1 I2D: score=1 STRING: ENSP00000373114
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    ENSG00000224320P304433I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0006486protein glycosylation ----
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    UGGT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGGT1 (UGGG1)

    2 HMDB Compounds for UGGT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Manganesemanganese 7439-96-5--

    3 Novoseek inferred chemical compound relationships for UGGT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 92.3 19 11283335 (3), 16154739 (1), 19470663 (1), 19466607 (1) (see all 15)
    polysaccharide 57.4 8 14730348 (3), 12671684 (2), 19222173 (1), 17304538 (1)
    glucose 22.5 7 12671684 (2), 19222173 (1), 12913004 (1), 14632257 (1) (see all 5)



    UGGT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UGGT1 gene (2 alternative transcripts): 
    NM_001025777.1  NM_020120.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430075 ENST00000438277(uc010fme.1) ENST00000376723 ENST00000259253
    ENST00000488439 ENST00000418197 ENST00000465836 ENST00000375990(uc002tps.3 uc002tpr.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UGGT1 (see all 59):
    hsa-miR-579 hsa-miR-4291 hsa-miR-361-5p hsa-miR-607 hsa-let-7d hsa-miR-624* hsa-miR-3921 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidUGGT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UGGT1
    Predesigned siRNA for gene silencing in human, mouse, rat UGGT1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UGGT1 (NM_020120)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGGT1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat UGGT1
      QuantiFast Probe-based Assays in human, mouse, rat UGGT1

    Selected AceView cDNA sequences (see all 182):

    NM_020120 BC041098 AI655867 BM040793 AF227905 AI080983 BX475218 AA847178 
    BP359091 BE550513 BF592808 AW002565 AA926726 AW135426 AI655525 CD106217 
    AA279123 AA810550 AK023240 BC047727 BU623794 AU132160 AA554920 AA279242 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UGGT1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                                      -                                                                                                     -               
    SP2:                          -           -                                                                                                     -               
    SP3:                                                                                                                                                            
    SP4:                    -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41a · 41b · 41c · 41d ^
    SP1:                                                        -                                                                                               -   
    SP2:                                                        -                                                                                               -   
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:        -                                                                                                                                                   

    ExUns: 42a · 42b ^ 43a · 43b · 43c
    SP1:  -                           
    SP2:  -                           
    SP3:  -                           
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for UGGT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    UGGT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCCAACC
    UGGT1 Expression
    About this image


    UGGT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    UGGT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGGT1 Protein Expression

    UniProtKB/Swiss-Prot: UGGG1_HUMAN, Q9NYU2
    Tissue specificity: Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UGGT1: 
              Glycosylation in human mouse rat
              Unfolded Protein Response in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UGGT1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uggt11 , 5 UDP-glucose glycoprotein glucosyltransferase 11, 5 86.72(n)1
    90.91(a)1
      1 (15.15 cM)5
    3200111  NM_198899.21  NP_942602.21 
     361415305 
    chicken
    (Gallus gallus)
    Aves UGGT11 UDP-glucose glycoprotein glucosyltransferase 1 78.13(n)
    85.15(a)
      424757  XM_004936963.1  XP_004937020.1 
    lizard
    (Anolis carolinensis)
    Reptilia UGGT16
    UDP-glucose glycoprotein glucosyltransferase 1
    85(a)
    1 ↔ 1
    3(36411431-36469479)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia uggt11 UDP-glucose glycoprotein glucosyltransferase 1 71.19(n)
    76.41(a)
      100380058  XM_004914484.1  XP_004914541.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG304166.12   -- 79.58(n)    BG304166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ugt1 UDP-glucose-glycoprotein glucosyltransferase 50.99(n)
    45.75(a)
      40055  NM_079427.3  NP_524151.2 
    worm
    (Caenorhabditis elegans)
    Secernentea uggt-11 uggt-1 51.57(n)
    44.54(a)
      181007  NM_076867.3  NP_509268.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KRE5(YOR336W)4 Protein required for beta-1,6 glucan biosynthesis; more   --   15(949773-953870) 854514  NP_014981.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EBS11 EBS1 48.23(n)
    39.7(a)
      843462  NM_001198441.1  NP_001185370.1 
    rice
    (Oryza sativa)
    Liliopsida Os.59002 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.73(n)    AK059298.1 


    ENSEMBL Gene Tree for UGGT1 (if available)
    TreeFam Gene Tree for UGGT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGGT1 gene
    UGGT22  
    1 SIMAP similar gene for UGGT1 using alignment to 6 protein entries:     UGGG1_HUMAN (see all proteins):
    UGGT2

    UGGT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UGGT1 (see all 2413)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1509432351,2
    --121153067(+) TTATTA/GTAACA 1 -- us2k10--------
    rs1407506531,2
    --121153128(+) CCAGTA/GAAACA 1 -- us2k10--------
    rs590018851,2
    C--121172455(+) AGACA-/GTCA  
            
    AAGAT
    2 -- int11Minor allele frequency- GTCA:0.00NA 2
    rs1432787921,2
    --128846821(+) TTCCAA/CATAAG 2 -- us2k10--------
    rs1161908551,2
    C,F--128846826(+) AATAAG/TATCCT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1466851731,2
    C--128846916(+) TAAACG/TGCAAG 2 -- us2k10--------
    rs1817160191,2
    C--128846921(+) TGCAAA/GGATGT 2 -- us2k10--------
    rs1150773091,2
    C,F--128846952(+) ACATGC/ACAAAG 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs344666231,2
    C,F--128847046(+) TTTTTT/-CTTTT 2 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs1839575711,2
    C--128847113(+) CATATG/TCACAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UGGT1 (128848754 - 128953251 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UGGT1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2538670CNV Deletion19546169
    esv2187638CNV Deletion18987734
    esv2459834CNV Deletion19546169
    esv998959CNV Deletion20482838
    esv2720736CNV Deletion23290073
    esv3599CNV Deletion18987735
    esv1434860CNV Deletion17803354
    esv2656463CNV Deletion23128226
    nsv819034CNV Loss19587683
    esv275386CNV Loss21479260

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605897    OMIM disorders: --

    9 diseases for UGGT1:    
    About MalaCards
    dysentery    sleeping sickness    tonsillitis    hepatitis
    thyroiditis    endotheliitis    cerebritis    malaria
    prostatitis


    UGGT1 for disorders           About GeneDecksing


    Export disorders for UGGT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGGT1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with UGGT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. (PubMed id 10694380)1, 2, 3, 9 Arnold S.M.... Kaufman R.J. (Biochemistry 2000)
    2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain. (PubMed id 12913004)1, 9 Arnold S.M. and Kaufman R.J. (J. Biol. Chem. 2003)
    6. The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin. (PubMed id 20498017)1, 9 Pearse B.R....Hebert D.N. (J. Cell Biol. 2010)
    7. Identification of HUGT1 as a potential BiP activator and a cellular target for improvement of recombinant protein production using a cDNA screening system. (PubMed id 19466607)1, 9 Ku S.C....Chao S.H. (Mol. Cells 2009)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)1 Haines D.S....Deshaies R.J. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56886 HGNC: 15663 AceView: UGCGL1 Ensembl:ENSG00000136731 euGenes: HUgn56886
    ECgene: UGGT1 Kegg: 56886 H-InvDB: UGGT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UGGT1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=UGGT1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UGGT1 gene:
    Search GeneIP for patents involving UGGT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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