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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGDH Gene

protein-coding   GIFtS: 67
GCID: GC04M039502

UDP-Glucose 6-Dehydrogenase

(Previous name: UDP-glucose dehydrogenase)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP-Glucose 6-Dehydrogenase1 2     EC 1.1.1.223 8
UDPGDH2 3 5     GDH2
UDP-Glucose Dehydrogenase1 2     UGD2
UDP-GlcDH2 3     Uridine Diphospho-Glucose Dehydrogenase2
UDP-Glc Dehydrogenase2 3     

External Ids:    HGNC: 125251   Entrez Gene: 73582   Ensembl: ENSG000001098147   OMIM: 6033705   UniProtKB: O607013   

Export aliases for UGDH gene to outside databases

Previous GC identifers: GC04M039674 GC04M039335 GC04M039397 GC04M039322 GC04M039176 GC04M038825


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UGDH Gene:
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the
biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These
glycosylated compounds are common components of the extracellular matrix and likely play roles in signal
transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by
transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple
transcript variants.(provided by RefSeq, May 2010)

GeneCards Summary for UGDH Gene: 
UGDH (UDP-glucose 6-dehydrogenase) is a protein-coding gene. Diseases associated with UGDH include hypoxia, and chordoma, and among its related super-pathways are Ascorbate and aldarate metabolism and Metabolic pathways. GO annotations related to this gene include electron carrier activity and UDP-glucose 6-dehydrogenase activity.

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate

Gene Wiki entry for UGDH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016297.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGDH gene promoter:
         STAT1   Sp1   Egr-1   STAT1beta   CUTL1   HNF-1A   STAT1alpha   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGDH promoter sequence
   Search SABiosciences Chromatin IP Primers for UGDH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.1   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

UGDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGDH gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M039502:  view genomic region     (about GC identifiers)

Start:
39,500,375 bp from pter      End:
39,529,931 bp from pter
Size:
29,557 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701 (See protein sequence)
Recommended Name: UDP-glucose 6-dehydrogenase  
Size: 494 amino acids; 55024 Da
Subunit: Homohexamer
6/9 PDB 3D structures from and Proteopedia for UGDH (see all 9):
2Q3E (3D)        2QG4 (3D)        3ITK (3D)        3KHU (3D)        3PRJ (3D)        3PTZ (3D)    
Secondary accessions: B3KUU2 B4DN25 O60589
Alternative splicing: 3 isoforms:  O60701-1   O60701-2   O60701-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UGDH: NX_O60701

Explore proteomics data for UGDH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60701

  • 4/18 DME Specific Peptides for UGDH (O60701) (see all 18)
     EKSTVPV  PIYEPGL  RINAWNS  DRVLIGG 

    UGDH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UGDH Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171629.1  NP_001171630.1  NP_003350.1  

    ENSEMBL proteins: 
     ENSP00000319501   ENSP00000422909   ENSP00000421757   ENSP00000426560   ENSP00000421954  
     ENSP00000425834   ENSP00000424059   ENSP00000424435   ENSP00000422603   ENSP00000422565  
     ENSP00000427708  
    Reactome Protein details: O60701
    Human Recombinant Protein Products for UGDH: 
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    Cloud-Clone Corp. Proteins for UGDH 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    UGDH for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR001732 UDP-Glc/GDP-Man_DH_N
     IPR008927 6-PGluconate_DH_C-like
     IPR014027 UDP-Glc/GDP-Man_DH_C
     IPR016040 NAD(P)-bd_dom
     IPR014026 UDP-Glc/GDP-Man_DH_dimer

    Graphical View of Domain Structure for InterPro Entry O60701

    ProtoNet protein and cluster: O60701

    1 Blocks protein domain: IPB001732 UDP-glucose/GDP-mannose dehydrogenase

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family


    UGDH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UGDH_HUMAN, O60701
    Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate
    Catalytic activity: UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH
    Enzyme regulation: UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch

         Genatlas biochemistry entry for UGDH:
    UDP-glucose dehydrogenase,converting UDP-glucose to UDP-glucuronate,involved in normal cell proliferation and
    migration,upregulated by androgens,playing a potentially important role in the control of sex steroid
    inactivation via glucuronidation in breast cancer cells

         Enzyme Number (IUBMB): EC 1.1.1.221 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003979UDP-glucose 6-dehydrogenase activity TAS--
    GO:0009055electron carrier activity TAS9737970
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0051287NAD binding IEA--
         
    UGDH for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGDH:
     Decreased number of cells in m 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ugdh):
     craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size 
     mortality/aging  normal  vision/eye 

    UGDH for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UGDH 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGDH 
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    SwitchGear 3'UTR luciferase reporter plasmidUGDH 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UGDH About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.67
    Pentose and glucuronate interconversions0.61
    Glucuronidation0.67
    Starch and sucrose metabolism0.41
    Ascorbate and aldarate metabolism0.61
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Biological oxidations
    Biological oxidations0.55
    Phase II conjugation0.55
    4GDP-mannose biosynthesis
    colanic acid building blocks biosynthesis0.40
    5UDP-D-xylose and UDP-D-glucuronate biosynthesis
    UDP-D-xylose and UDP-D-glucuronate biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for UGDH
        Glucuronidation
    colanic acid building blocks biosynthesis
    UDP-D-xylose and UDP-D-glucuronate biosynthesis

    5        Reactome Pathways for UGDH
        Formation of the active cofactor, UDP-glucuronate
    Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation


    5         Kegg Pathways  (Kegg details for UGDH):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Starch and sucrose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from
    UDP-alpha-D-glucose: step 1/1


    UGDH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for UGDH (O607012, 3 ENSP000003195014) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V0D1P614213, ENSP000002909494I2D: score=2 STRING: ENSP00000290949
    SIRT3Q9NTG73, ENSP000003721914I2D: score=2 STRING: ENSP00000372191
    DHHO433233, ENSP000002669914I2D: score=1 STRING: ENSP00000266991
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0006011UDP-glucose metabolic process TAS9737970
    GO:0006024glycosaminoglycan biosynthetic process TAS9737970
    GO:0006065UDP-glucuronate biosynthetic process TAS--
    GO:0006805xenobiotic metabolic process TAS--

    UGDH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGDH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGDH

    5 HMDB Compounds for UGDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Uridine diphosphate glucose(UPD)-glucose (see all 24)133-89-1--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for UGDH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 1472079 17016423 3804697

    10/23 Novoseek inferred chemical compound relationships for UGDH gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 95.7 136 16453102 (5), 1777115 (4), 10336992 (3), 15044486 (3) (see all 63)
    udp glucuronic acid 94.8 35 2287590 (1), 7868856 (1), 12682078 (1), 16002992 (1) (see all 22)
    udpxylose 82.4 2 16453102 (1)
    glycosaminoglycan 63.9 9 18717819 (2), 12910476 (1), 9737970 (1), 16418163 (1) (see all 5)
    nad+ 54.1 5 15247292 (3), 15044486 (1)
    chondroitin 53.9 1 10806213 (1)
    chondroitin sulfate 51.9 6 2287590 (1), 8014943 (1)
    6-phosphogluconate 51.4 2 12196534 (1), 12604241 (1)
    methyl viologen 46.8 2 12526718 (1), 12673771 (1)
    hyaluronic acid 45 6 10068780 (2), 2287590 (1), 16023581 (1)

    Search CenterWatch for drugs/clinical trials and news about UGDH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for UGDH gene (3 alternative transcripts): 
    NM_001184700.1  NM_001184701.1  NM_003359.3  

    Unigene Cluster for UGDH:

    UDP-glucose 6-dehydrogenase
    Hs.572518  [show with all ESTs]
    Unigene Representative Sequence: NM_003359
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316423(uc003guk.2 uc011byp.2 uc003gul.2) ENST00000501493
    ENST00000506179 ENST00000507089 ENST00000515021 ENST00000514106 ENST00000510881
    ENST00000503779 ENST00000509391 ENST00000515398 ENST00000505698 ENST00000510490

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    Additional mRNA sequence: 

    AF049126.1 AF061016.1 AJ007702.1 AK097930.1 AK297737.1 BC013430.1 BC022781.1 

    16 DOTS entries:

    DT.91770177  DT.95284989  DT.100753327  DT.102827162  DT.91770181  DT.121230260  DT.99934894  DT.100724687 
    DT.121230198  DT.121230261  DT.121230313  DT.95284980  DT.99967462  DT.121230308  DT.121230324  DT.91924019 

    24/222 AceView cDNA sequences (see all 222):

    BM454592 BU631548 BQ960028 BQ010148 BU153716 BX399667 AA992570 T09009 
    BQ269780 AA307893 BX495002 BQ775140 CD677665 BG617628 BP337253 BU521597 
    BM459904 BQ651558 BP377244 BM126381 AL708740 AU132803 AA320883 BC022781 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UGDH (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                                                            
    SP2:                          -     -     -                                                                     
    SP3:                                                                                                            
    SP4:                          -                                                                                 
    SP5:                          -     -     -                                                                     


    ECgene alternative splicing isoforms for UGDH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGDH expression in normal human tissues (normalized intensities)      UGDH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGGTCTGG
    UGDH Expression
    About this image


    UGDH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 11 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
             limb/hindlimb   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             urinary bladder ; urothelial cells   
             visceral organ/bladder   

    See UGDH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGDH

    SOURCE GeneReport for Unigene cluster: Hs.572518

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UGDH gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugdh1 , 5 UDP-glucose dehydrogenase1, 5 89.86(n)1
    97.97(a)1
      5 (33.67 cM)5
    222351  NM_009466.21  NP_033492.11 
     654132025 
    chicken
    (Gallus gallus)
    Aves UGDH1 UDP-glucose 6-dehydrogenase 82.25(n)
    93.72(a)
      422792  NM_001012581.1  NP_001012599.1 
    lizard
    (Anolis carolinensis)
    Reptilia UGDH6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    5(99670120-99676278)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525112 similar to UDP-glucose dehydrogenase 77.36(n)    AY014958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ugdh2 UDP-glucose dehydrogenase 76.97(n)   116991  AF361478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sgl1 , 3 mesoderm migration UDP-glucose
    6-dehydrogenase3
    sugarless1
    68(a)3
    61.28(n)1
    69.21(a)1
      3 65D53
    387601  NM_057632.31  NP_476980.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sqv-41 Protein SQV-4 61.71(n)
    66.52(a)
      179484  NM_073329.6  NP_505730.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UGD11 UDP-glucose dehydrogenase 1 61.23(n)
    63.04(a)
      839197  NM_102419.3  NP_173979.1 
    rice
    (Oryza sativa)
    Liliopsida Os.104732 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.44(n)    AK105768.1 


    ENSEMBL Gene Tree for UGDH (if available)
    TreeFam Gene Tree for UGDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGDH gene
    2 SIMAP similar genes for UGDH using alignment to 8 protein entries:     UGDH_HUMAN (see all proteins):
    GDH    ugd

    UGDH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/603 SNPs in UGDH are shown (see all 603)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449902361,2
    C--38856225(+) CAAAAC/TGGTTA 3 -- us2k10--------
    rs1164642001,2
    F--39500063(+) CTGGCC/GTTAAG 3 -- ds5001 int11Minor allele frequency- G:0.01WA 118
    rs1490137071,2
    C--39500114(+) TGCATA/GAGCCA 3 -- ds5001 int10--------
    rs1130039771,2
    C,F--39500151(+) ATGACC/TATGTA 3 -- ds5001 int12Minor allele frequency- T:0.03NA 122
    rs119357511,2
    C,F,A,H--39500187(+) ACTCAT/CGGCTG 3 -- ds5001 int15Minor allele frequency- C:0.03NS EA NA 538
    rs757112861,2
    F--39500237(+) TTTGCT/CAAATT 3 -- ds5001 int11Minor allele frequency- C:0.01WA 118
    rs131354751,2
    C,F,A--39500244(+) AATTCT/CCTCCC 3 -- ds5001 int111Minor allele frequency- C:0.37NA CSA WA EA 510
    rs1438080391,2
    C--39500489(+) AGGATA/GAGACC 3 -- ut310--------
    rs14501,2
    C,F,A,H--39500514(+) CAAACT/CGTACA 3 -- ut3134Minor allele frequency- C:0.32MN NA NS EA 3644
    rs1817292451,2
    --39500516(+) AACTGA/TACATT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for UGDH (39500375 - 39529931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UGDH:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5527n71CNV Loss21882294
    nsv878942CNV Loss21882294
    nsv878946CNV Loss21882294
    nsv878943CNV Gain21882294


    Human Gene Mutation Database (HGMD): UGDH
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603370    OMIM disorders: --

    17 diseases for UGDH:    About MalaCards
    hypoxia    chordoma    morbid obesity    synovitis
    graves' disease    hyperglycemia    peritonitis    obesity
    rheumatoid arthritis    arthritis    alcoholism    neuroblastoma
    tuberculosis    breast cancer    prostate cancer    prostatitis
    neuronitis


    UGDH for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for UGDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 15.9 2 15059280 (1), 10068780 (1)
    breast cancer 0 4 10499502 (2), 16158268 (1)

    Genetic Association Database (GAD): UGDH
    Human Genome Epidemiology (HuGE) Navigator: UGDH (1 document)

    Export disorders for UGDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGDH gene, integrated from 9 sources (see all 121):
    (articles sorted by number of sources associating them with UGDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human and mouse UDP- glucose dehydrogenase genes. (PubMed id 9737970)1, 2, 3, 9 Spicer A.P.... Seldin M.F. (1998)
    2. cDNA cloning and expression analysis of the human UDPglucose dehydrogenase. (PubMed id 9850599)1, 2, 9 Peng H.L.... Chang H.Y. (1998)
    3. Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. (PubMed id 10575217)1, 3, 9 Marcu O....Marsh J.L. (1999)
    4. Structural and kinetic evidence that catalytic reactio n of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thio ester enzyme intermediates. (PubMed id 22123821)1, 2 Egger S....Nidetzky B. (2012)
    5. Structure and mechanism of human UDP-glucose 6-dehydr ogenase. (PubMed id 21502315)1, 2 Egger S....Nidetzky B. (2011)
    6. Conformational flexibility in the allosteric regulati on of human UDP-I+-D-glucose 6-dehydrogenase. (PubMed id 21961565)1, 2 Sennett N.C....Wood Z.A. (2011)
    7. Structural basis of cooperativity in human UDP-glucos e dehydrogenase. (PubMed id 21984906)1, 2 Rajakannan V....Robinson R.C. (2011)
    8. Genome-wide association identifies candidate genes th at influence the human electroencephalogram. (PubMed id 20421487)1, 4 Hodgkinson C.A....Goldman D. (2010)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7358 HGNC: 12525 AceView: UGDH Ensembl:ENSG00000109814 euGenes: HUgn7358
    ECgene: UGDH Kegg: 7358 H-InvDB: UGDH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGDH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UGDH gene:
    Search GeneIP for patents involving UGDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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