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Aliases for UGDH Gene

Aliases for UGDH Gene

  • UDP-Glucose 6-Dehydrogenase 2 3 5
  • UDP-Glucose Dehydrogenase 2 3
  • UDP-Glc Dehydrogenase 3 4
  • EC 1.1.1.22 4 63
  • UDP-GlcDH 3 4
  • UDPGDH 3 4
  • Uridine Diphospho-Glucose Dehydrogenase 3
  • GDH 3
  • UGD 3

External Ids for UGDH Gene

Previous GeneCards Identifiers for UGDH Gene

  • GC04M039674
  • GC04M039335
  • GC04M039397
  • GC04M039322
  • GC04M039176
  • GC04M038825

Summaries for UGDH Gene

Entrez Gene Summary for UGDH Gene

  • The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for UGDH Gene

UGDH (UDP-Glucose 6-Dehydrogenase) is a Protein Coding gene. Among its related pathways are Phase II conjugation and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include electron carrier activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.

UniProtKB/Swiss-Prot for UGDH Gene

  • Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Gene Wiki entry for UGDH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGDH Gene

Genomics for UGDH Gene

Regulatory Elements for UGDH Gene

Enhancers for UGDH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UGDH on UCSC Golden Path with GeneCards custom track

Genomic Location for UGDH Gene

Chromosome:
4
Start:
39,498,755 bp from pter
End:
39,528,311 bp from pter
Size:
29,557 bases
Orientation:
Minus strand

Genomic View for UGDH Gene

Genes around UGDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGDH Gene

Proteins for UGDH Gene

  • Protein details for UGDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60701-UGDH_HUMAN
    Recommended name:
    UDP-glucose 6-dehydrogenase
    Protein Accession:
    O60701
    Secondary Accessions:
    • B3KUU2
    • B4DN25
    • O60589

    Protein attributes for UGDH Gene

    Size:
    494 amino acids
    Molecular mass:
    55024 Da
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for UGDH Gene

    Alternative splice isoforms for UGDH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGDH Gene

Proteomics data for UGDH Gene at MOPED

Post-translational modifications for UGDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UGDH Gene

Graphical View of Domain Structure for InterPro Entry

O60701

UniProtKB/Swiss-Prot:

UGDH_HUMAN :
  • Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Family:
  • Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
genes like me logo Genes that share domains with UGDH: view

No data available for Gene Families for UGDH Gene

Function for UGDH Gene

Molecular function for UGDH Gene

GENATLAS Biochemistry:
UDP-glucose dehydrogenase,converting UDP-glucose to UDP-glucuronate,involved in normal cell proliferation and migration,upregulated by androgens,playing a potentially important role in the control of sex steroid inactivation via glucuronidation in breast cancer cells
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch.
UniProtKB/Swiss-Prot Function:
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Enzyme Numbers (IUBMB) for UGDH Gene

genes like me logo Genes that share phenotypes with UGDH: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UGDH

miRNA for UGDH Gene

miRTarBase miRNAs that target UGDH

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGDH Gene

Localization for UGDH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGDH Gene COMPARTMENTS Subcellular localization image for UGDH gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UGDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with UGDH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UGDH Gene

Pathways & Interactions for UGDH Gene

genes like me logo Genes that share pathways with UGDH: view

UniProtKB/Swiss-Prot O60701-UGDH_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.

Gene Ontology (GO) - Biological Process for UGDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001702 gastrulation with mouth forming second IEA --
GO:0005975 carbohydrate metabolic process IBA --
GO:0006011 UDP-glucose metabolic process TAS 9737970
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with UGDH: view

No data available for SIGNOR curated interactions for UGDH Gene

Drugs & Compounds for UGDH Gene

(7) Drugs for UGDH Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(21) Additional Compounds for UGDH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Uridine diphosphate glucose
  • (UDP)glucose
  • (UPD)-glucose
  • UDP Glucose
  • UDP-a-D-Glucose
  • UDP-alpha-D-Glucose
133-89-1
Uridine diphosphate glucuronic acid
  • a-D-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • a-D-Glucopyranuronic acid ester with uridine 5'-pyrophosphate
  • alpha-D-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
  • alpha-delta-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • alpha-delta-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
2616-64-0
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with UGDH: view

Transcripts for UGDH Gene

Unigene Clusters for UGDH Gene

UDP-glucose 6-dehydrogenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGDH Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: - - -
SP3:
SP4: -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - -

Relevant External Links for UGDH Gene

GeneLoc Exon Structure for
UGDH
ECgene alternative splicing isoforms for
UGDH

Expression for UGDH Gene

mRNA expression in normal human tissues for UGDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGDH Gene

This gene is overexpressed in Liver (x6.4).

Protein differential expression in normal tissues from HIPED for UGDH Gene

This gene is overexpressed in Bone marrow stromal cell (19.2), Liver (6.3), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGDH Gene



SOURCE GeneReport for Unigene cluster for UGDH Gene Hs.572518

mRNA Expression by UniProt/SwissProt for UGDH Gene

O60701-UGDH_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with UGDH: view

Protein tissue co-expression partners for UGDH Gene

- Elite partner

Primer Products

Orthologs for UGDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGDH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UGDH 35
  • 93.45 (n)
  • 98.58 (a)
UGDH 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UGDH 35
  • 93.99 (n)
  • 99.39 (a)
UGDH 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ugdh 35
  • 89.86 (n)
  • 97.97 (a)
Ugdh 16
Ugdh 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UGDH 35
  • 99.8 (n)
  • 100 (a)
UGDH 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugdh 35
  • 89.79 (n)
  • 97.77 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UGDH 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves UGDH 35
  • 82.25 (n)
  • 93.72 (a)
UGDH 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UGDH 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1204 35
ugdh 35
  • 78 (n)
  • 88.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52511 35
zebrafish
(Danio rerio)
Actinopterygii ugdh 35
  • 73.81 (n)
  • 85.31 (a)
ugdh 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sgl 37
  • 68 (a)
sgl 35
  • 61.28 (n)
  • 69.21 (a)
sgl 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006532 35
  • 61.17 (n)
  • 69.63 (a)
worm
(Caenorhabditis elegans)
Secernentea sqv-4 35
  • 61.63 (n)
  • 66.52 (a)
sqv-4 36
  • 63 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39320 35
  • 60.45 (n)
  • 63.16 (a)
soybean
(Glycine max)
eudicotyledons Gma.6350 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8544 35
barley
(Hordeum vulgare)
Liliopsida Hv.12401 35
rice
(Oryza sativa)
Liliopsida Os.10473 35
Os03g0604200 35
  • 54.92 (n)
  • 62.36 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2657 35
corn
(Zea mays)
Liliopsida Zm.4986 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.748 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8331 36
  • 68 (a)
OneToOne
Species with no ortholog for UGDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UGDH Gene

ENSEMBL:
Gene Tree for UGDH (if available)
TreeFam:
Gene Tree for UGDH (if available)

Paralogs for UGDH Gene

(2) SIMAP similar genes for UGDH Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with UGDH: view

No data available for Paralogs for UGDH Gene

Variants for UGDH Gene

Sequence variations from dbSNP and Humsavar for UGDH Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1450 -- 39,498,894(+) CAAAC(C/T)GTACA utr-variant-3-prime
rs1129052 -- 39,508,644(-) AGCTG(C/T)TTCCA reference, synonymous-codon
rs1046573 -- 39,499,466(-) TCATT(C/T)CTCCT utr-variant-3-prime
rs1379819 -- 39,504,524(-) TTGTT(A/G)TTGCT intron-variant
rs2608823 -- 39,500,436(-) GAGTA(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGDH Gene

Variant ID Type Subtype PubMed ID
nsv878942 CNV Loss 21882294
nsv878943 CNV Gain 21882294
dgv5527n71 CNV Loss 21882294
nsv878946 CNV Loss 21882294

Variation tolerance for UGDH Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGDH Gene

Human Gene Mutation Database (HGMD)
UGDH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGDH Gene

Disorders for UGDH Gene

Relevant External Links for UGDH

Genetic Association Database (GAD)
UGDH
Human Genome Epidemiology (HuGE) Navigator
UGDH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGDH

No disorders were found for UGDH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGDH Gene

Publications for UGDH Gene

  1. Molecular cloning and characterization of the human and mouse UDP- glucose dehydrogenase genes. (PMID: 9737970) Spicer A.P. … Seldin M.F. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. (PMID: 10575217) Marcu O. … Marsh J.L. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer. (PMID: 19676054) Huang D. … Hemstreet G.P. (Int. J. Cancer 2010) 3 23
  4. Computational analysis of the quaternary structural changes induced by point mutations in human UDP-glucose dehydrogenase. (PMID: 19358821) Lee H.S. … Choe H. (Arch. Biochem. Biophys. 2009) 3 23
  5. Epstein-Barr virus latent membrane protein 2A upregulates UDP-glucose dehydrogenase gene expression via ERK and PI3K/Akt pathway. (PMID: 18717819) Pan Y.R. … Chang H.Y. (Cell. Microbiol. 2008) 3 23

Products for UGDH Gene

Sources for UGDH Gene

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