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Aliases for UGDH Gene

Aliases for UGDH Gene

  • UDP-Glucose 6-Dehydrogenase 2 3
  • UDPGDH 3 4 6
  • UDP-Glucose Dehydrogenase 2 3
  • UDP-Glc Dehydrogenase 3 4
  • EC 4 63
  • UDP-GlcDH 3 4
  • Uridine Diphospho-Glucose Dehydrogenase 3
  • GDH 3
  • UGD 3

External Ids for UGDH Gene

Previous GeneCards Identifiers for UGDH Gene

  • GC04M039674
  • GC04M039335
  • GC04M039397
  • GC04M039322
  • GC04M039176
  • GC04M038825

Summaries for UGDH Gene

Entrez Gene Summary for UGDH Gene

  • The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for UGDH Gene

UGDH (UDP-Glucose 6-Dehydrogenase) is a Protein Coding gene. Diseases associated with UGDH include hypoxia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and UDP-glucose 6-dehydrogenase activity.

UniProtKB/Swiss-Prot for UGDH Gene

  • Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate

Gene Wiki entry for UGDH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGDH Gene

Genomics for UGDH Gene

Regulatory Elements for UGDH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UGDH Gene

39,498,755 bp from pter
39,528,311 bp from pter
29,557 bases
Minus strand

Genomic View for UGDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGDH Gene

Proteins for UGDH Gene

  • Protein details for UGDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucose 6-dehydrogenase
    Protein Accession:
    Secondary Accessions:
    • B3KUU2
    • B4DN25
    • O60589

    Protein attributes for UGDH Gene

    494 amino acids
    Molecular mass:
    55024 Da
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for UGDH Gene

    Alternative splice isoforms for UGDH Gene


neXtProt entry for UGDH Gene

Proteomics data for UGDH Gene at MOPED

Post-translational modifications for UGDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for UGDH Gene

Graphical View of Domain Structure for InterPro Entry



  • O60701
  • Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
genes like me logo Genes that share domains with UGDH: view

No data available for Gene Families for UGDH Gene

Function for UGDH Gene

Molecular function for UGDH Gene

GENATLAS Biochemistry:
UDP-glucose dehydrogenase,converting UDP-glucose to UDP-glucuronate,involved in normal cell proliferation and migration,upregulated by androgens,playing a potentially important role in the control of sex steroid inactivation via glucuronidation in breast cancer cells
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH
UniProtKB/Swiss-Prot EnzymeRegulation:
UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch.
UniProtKB/Swiss-Prot Function:
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate

Enzyme Numbers (IUBMB) for UGDH Gene

Gene Ontology (GO) - Molecular Function for UGDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003979 UDP-glucose 6-dehydrogenase activity TAS --
GO:0009055 electron carrier activity TAS 9737970
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
GO:0051287 NAD binding IEA --
genes like me logo Genes that share ontologies with UGDH: view
genes like me logo Genes that share phenotypes with UGDH: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UGDH

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UGDH Gene

Localization for UGDH Gene

Subcellular locations from

Jensen Localization Image for UGDH Gene COMPARTMENTS Subcellular localization image for UGDH gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UGDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with UGDH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UGDH Gene

Pathways for UGDH Gene

genes like me logo Genes that share pathways with UGDH: view

UniProtKB/Swiss-Prot O60701-UGDH_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1

Gene Ontology (GO) - Biological Process for UGDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001702 gastrulation with mouth forming second IEA --
GO:0006011 UDP-glucose metabolic process TAS 9737970
GO:0006024 glycosaminoglycan biosynthetic process TAS 9737970
GO:0006065 UDP-glucuronate biosynthetic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
genes like me logo Genes that share ontologies with UGDH: view

Compounds for UGDH Gene

(5) HMDB Compounds for UGDH Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
  • 1,4-Dihydronicotinamide adenine dinucleotide
Uridine diphosphate glucose
  • (UPD)-glucose
Uridine diphosphate glucuronic acid
  • UDP glucuronate
  • Dihydrogen oxide

(1) Drugbank Compounds for UGDH Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • beta-DPNH
606-68-8 target

(23) Novoseek inferred chemical compound relationships for UGDH Gene

Compound -log(P) Hits PubMed IDs
udpglucose 95.7 95
udp glucuronic acid 94.8 22
udpxylose 82.4 1
glycosaminoglycan 63.9 6
nad+ 54.1 4
genes like me logo Genes that share compounds with UGDH: view

Transcripts for UGDH Gene

Unigene Clusters for UGDH Gene

UDP-glucose 6-dehydrogenase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UGDH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGDH Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP2: - - -
SP4: -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - -

Relevant External Links for UGDH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UGDH Gene

mRNA expression in normal human tissues for UGDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGDH Gene

This gene is overexpressed in Liver (6.4).

Protein differential expression in normal tissues for UGDH Gene

This gene is overexpressed in Bone marrow stromal cell (19.2), Liver (6.3), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGDH Gene

SOURCE GeneReport for Unigene cluster for UGDH Gene Hs.572518

mRNA Expression by UniProt/SwissProt for UGDH Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with UGDH: view

Expression partners for UGDH Gene

In Situ Assay Products

Orthologs for UGDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGDH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UGDH 35
  • 93.45 (n)
  • 98.58 (a)
  • 99 (a)
(Canis familiaris)
Mammalia UGDH 35
  • 93.99 (n)
  • 99.39 (a)
  • 99 (a)
(Mus musculus)
Mammalia Ugdh 35
  • 89.86 (n)
  • 97.97 (a)
Ugdh 16
Ugdh 36
  • 98 (a)
(Pan troglodytes)
Mammalia UGDH 35
  • 99.8 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ugdh 35
  • 89.79 (n)
  • 97.77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
-- 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia UGDH 36
  • 97 (a)
(Gallus gallus)
Aves UGDH 35
  • 82.25 (n)
  • 93.72 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia UGDH 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1204 35
ugdh 35
  • 78 (n)
  • 88.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52511 35
(Danio rerio)
Actinopterygii ugdh 35
  • 73.81 (n)
  • 85.31 (a)
ugdh 36
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta sgl 37
  • 68 (a)
sgl 35
  • 61.28 (n)
  • 69.21 (a)
sgl 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006532 35
  • 61.17 (n)
  • 69.63 (a)
(Caenorhabditis elegans)
Secernentea sqv-4 35
  • 61.63 (n)
  • 66.52 (a)
sqv-4 36
  • 63 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39320 35
  • 60.45 (n)
  • 63.16 (a)
(Glycine max)
eudicotyledons Gma.6350 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8544 35
(Hordeum vulgare)
Liliopsida Hv.12401 35
(Oryza sativa)
Liliopsida Os.10473 35
Os03g0604200 35
  • 54.92 (n)
  • 62.36 (a)
(Triticum aestivum)
Liliopsida Ta.2657 35
(Zea mays)
Liliopsida Zm.4986 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.748 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8331 36
  • 68 (a)
Species with no ortholog for UGDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UGDH Gene

Gene Tree for UGDH (if available)
Gene Tree for UGDH (if available)

Paralogs for UGDH Gene

Selected SIMAP similar genes for UGDH Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with UGDH: view

No data available for Paralogs for UGDH Gene

Variants for UGDH Gene

Sequence variations from dbSNP and Humsavar for UGDH Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1450 -- 39,498,894(+) CAAAC(C/T)GTACA utr-variant-3-prime
rs1046573 -- 39,499,466(-) TCATT(C/T)CTCCT utr-variant-3-prime
rs1129052 -- 39,508,644(-) AGCTG(C/T)TTCCA synonymous-codon, reference
rs1379819 -- 39,504,524(-) TTGTT(A/G)TTGCT intron-variant
rs2608823 -- 39,500,436(-) GAGTA(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGDH Gene

Variant ID Type Subtype PubMed ID
nsv878942 CNV Loss 21882294
nsv878943 CNV Gain 21882294
dgv5527n71 CNV Loss 21882294
nsv878946 CNV Loss 21882294

Relevant External Links for UGDH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGDH Gene

Disorders for UGDH Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for UGDH Gene in MalaCards »

(1) Diseases for UGDH Gene including...

(2) Novoseek inferred disease relationships for UGDH Gene

Disease -log(P) Hits PubMed IDs
rheumatoid arthritis 15.9 2
breast cancer 0 3

Relevant External Links for UGDH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UGDH: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for UGDH Gene

Publications for UGDH Gene

  1. Molecular cloning and characterization of the human and mouse UDP- glucose dehydrogenase genes. (PMID: 9737970) Spicer A.P. … Seldin M.F. (J. Biol. Chem. 1998) 2 3 4 23
  2. Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. (PMID: 10575217) Marcu O. … Marsh J.L. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. cDNA cloning and expression analysis of the human UDPglucose dehydrogenase. (PMID: 9850599) Peng H.L. … Chang H.Y. (Proc. Natl. Sci. Counc. Repub. China, B, Life Sci. 1998) 3 4 23
  4. Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia. (PMID: 12682078) Bontemps Y. … Wegrowski Y. (J. Biol. Chem. 2003) 3 23
  5. Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations. (PMID: 15044486) Sommer B.J. … Simpson M.A. (J. Biol. Chem. 2004) 3 23

Products for UGDH Gene

  • Addgene plasmids for UGDH

Sources for UGDH Gene

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