Aliases for UGDH Gene
External Ids for UGDH Gene
Previous GeneCards Identifiers for UGDH Gene
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
GeneCards Summary for UGDH Gene
UGDH (UDP-Glucose 6-Dehydrogenase) is a Protein Coding gene. Diseases associated with UGDH include chordoma. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include electron carrier activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.
UniProtKB/Swiss-Prot for UGDH Gene
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate