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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGDH Gene

protein-coding   GIFtS: 64
GCID: GC04M039502

UDP-glucose 6-dehydrogenase

(Previous name: UDP-glucose dehydrogenase )
 Explore 20 diseases affiliated with
UGDH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UGDH    

Aliases
for UGDH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP-Glucose 6-Dehydrogenase1 2     EC 1.1.1.223 8
UDPGDH2 3 5     GDH2
UDP-Glucose Dehydrogenase1 2     UGD2
UDP-GlcDH2 3     Uridine Diphospho-Glucose Dehydrogenase2
UDP-Glc Dehydrogenase2 3     

External Ids:    HGNC: 125251   Entrez Gene: 73582   Ensembl: ENSG000001098147   OMIM: 6033705   UniProtKB: O607013   

Export aliases for UGDH gene to outside databases

Previous GC identifers: GC04M039674 GC04M039335 GC04M039397 GC04M039322 GC04M039176 GC04M038825


Summaries
for UGDH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UGDH:
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis
of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are
common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer
growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and
down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate

Gene Wiki entry for UGDH


Genomic Views
for UGDH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016297.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGDH gene promoter:
         STAT1   Sp1   Egr-1   STAT1beta   CUTL1   HNF-1A   STAT1alpha   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UGDH promoter sequence
   Search SABiosciences Chromatin IP Primers for UGDH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.1   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

UGDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGDH gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M039502:  view genomic region     (about GC identifiers)

Start:
 39,500,375 bp from pter      End:
 39,529,931 bp from pter
Size:
 29,557 bases      Orientation:
 minus strand

Proteins
for UGDH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701 (See protein sequence)
Recommended Name: UDP-glucose 6-dehydrogenase  
Size: 494 amino acids; 55024 Da
Subunit: Homohexamer
6/9 PDB 3D structures from and Proteopedia for UGDH (see all 9):
2Q3E (3D)        2QG4 (3D)        3ITK (3D)        3KHU (3D)        3PRJ (3D)        3PTZ (3D)    
Secondary accessions: B3KUU2 B4DN25 O60589
Alternative splicing: 3 isoforms:  O60701-1   O60701-2   O60701-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UGDH: NX_O60701

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60701

    • 4/18 DME Specific Peptides for UGDH (O60701) (see all 18)
     EKSTVPV  PIYEPGL  RINAWNS  DRVLIGG 

    UGDH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171629.1  NP_001171630.1  NP_003350.1  

    ENSEMBL proteins: 
     ENSP00000319501   ENSP00000422909   ENSP00000421757   ENSP00000426560   ENSP00000421954  
     ENSP00000425834   ENSP00000424059   ENSP00000424435   ENSP00000422603   ENSP00000422565  
     ENSP00000427708  
    Reactome Protein details: O60701
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: UGDH
    OriGene Protein Over-expression Lysate (see all 2): UGDH
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    Novus Biologicals UGDH Proteins
    Novus Biologicals UGDH Lysates
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    ProSpec Recombinant Protein for UGDH
    Uscn Proteins for UGDH

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    UGDH for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UGDH

    Protein Domains /
    Families
    for UGDH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UGDH for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001732 UDP-Glc/GDP-Man_DH_N
     IPR008927 6-PGluconate_DH_C-like
     IPR014027 UDP-Glc/GDP-Man_DH_C
     IPR016040 NAD(P)-bd_dom
     IPR014026 UDP-Glc/GDP-Man_DH_dimer

    Graphical View of Domain Structure for InterPro Entry O60701

    ProtoNet protein and cluster: O60701

    1 Blocks protein family: IPB001732 UDP-glucose/GDP-mannose dehydrogenase

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family


    Function
    for UGDH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate
    Catalytic activity: UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH
    Enzyme regulation: UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch

         Genatlas biochemistry entry for UGDH:
    UDP-glucose dehydrogenase,converting UDP-glucose to UDP-glucuronate,involved in normal cell proliferation and
    migration,upregulated by androgens,playing a potentially important role in the control of sex steroid inactivation via
    glucuronidation in breast cancer cells

    Enzyme Number (IUBMB): EC 1.1.1.221 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UGDH
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate UGDH (see all 34):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-miR-3146 hsa-miR-548k hsa-miR-624* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: UGDH 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGDH (see all 7)
    OriGene shRNA RFP: UGDH
    OriGene siRNA: UGDH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGDH

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UGDH

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGDH (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for UGDH

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003979UDP-glucose 6-dehydrogenase activity TAS--
    GO:0009055electron carrier activity TAS9737970
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0051287NAD binding IEA--


    UGDH for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UGDH:
     Decreased number of cells in m 

    Animal Models:
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ugdh):
     craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size 
     mortality/aging  normal  vision/eye 

    UGDH for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UGDH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    		Glucuronidation1.00
    		Starch and sucrose metabolism0.42
    		Glucuronidation0.67
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Pentose and glucuronate interconversions
    		Pentose and glucuronate interconversions1.00
    		Ascorbate and aldarate metabolism0.62
    4Biological oxidations
    		Biological oxidations1.00
    		Phase II conjugation0.52
    5Formation of the active cofactor, UDP-glucuronate
    		Formation of the active cofactor, UDP-glucuronate1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for UGDH 
        Glucuronidation
    colanic acid building blocks biosynthesis
    UDP-D-xylose and UDP-D-glucuronate biosynthesis

    5        Reactome Pathways for UGDH
        Formation of the active cofactor, UDP-glucuronate
    Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation


    5         Kegg Pathways  (Kegg details for UGDH):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Starch and sucrose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from
    UDP-alpha-D-glucose: step 1/1


    UGDH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for UGDH (O607012, 3 ENSP000003195014) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V0D1P614213, ENSP000002909494I2D: score=2 STRING: ENSP00000290949
    SIRT3Q9NTG73, ENSP000003721914I2D: score=2 STRING: ENSP00000372191
    DHHO433233, ENSP000002669914I2D: score=1 STRING: ENSP00000266991
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0006011UDP-glucose metabolic process TAS9737970
    GO:0006024glycosaminoglycan biosynthetic process TAS9737970
    GO:0006065UDP-glucuronate biosynthetic process TAS--
    GO:0006805xenobiotic metabolic process TAS--


    UGDH for ontologies           About GeneDecksing



    Drugs & Compounds
    for UGDH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGDH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGDH

    5 HMDB Compounds for UGDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Uridine diphosphate glucose(UPD)-glucose (see all 24)133-89-1--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for UGDH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 1472079 17016423 3804697

    10/23 Novoseek chemical compound relationships for UGDH gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 95.7 136 16453102 (5), 1777115 (4), 10336992 (3), 15044486 (3) (see all 63)
    udp glucuronic acid 94.8 35 2287590 (1), 7868856 (1), 12682078 (1), 16002992 (1) (see all 22)
    udpxylose 82.4 2 16453102 (1)
    glycosaminoglycan 63.9 9 18717819 (2), 12910476 (1), 9737970 (1), 16418163 (1) (see all 5)
    nad+ 54.1 5 15247292 (3), 15044486 (1)
    chondroitin 53.9 1 10806213 (1)
    chondroitin sulfate 51.9 6 2287590 (1), 8014943 (1)
    6-phosphogluconate 51.4 2 12196534 (1), 12604241 (1)
    methyl viologen 46.8 2 12526718 (1), 12673771 (1)
    hyaluronic acid 45 6 10068780 (2), 2287590 (1), 16023581 (1)

    Search CenterWatch for drugs/clinical trials and news about UGDH 

    Transcripts
    for UGDH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UGDH gene (3 alternative transcripts): 
    NM_001184700.1  NM_001184701.1  NM_003359.3  

    Unigene Cluster for UGDH:

    UDP-glucose 6-dehydrogenase
    Hs.572518  [show with all ESTs]
    Unigene Representative Sequence: NM_003359
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316423(uc003guk.2 uc011byp.2 uc003gul.2) ENST00000501493
    ENST00000506179 ENST00000507089 ENST00000515021 ENST00000514106 ENST00000510881
    ENST00000503779 ENST00000509391 ENST00000515398 ENST00000505698 ENST00000510490


    miRNA
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    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate UGDH (see all 34):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-miR-3146 hsa-miR-548k hsa-miR-624* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: UGDH 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF049126.1 AF061016.1 AJ007702.1 AK097930.1 AK297737.1 BC013430.1 BC022781.1 

    16 DOTS entries:

    DT.91770177  DT.95284989  DT.100753327  DT.102827162  DT.91770181  DT.121230260  DT.99934894  DT.100724687 
    DT.121230198  DT.121230261  DT.121230313  DT.95284980  DT.99967462  DT.121230308  DT.121230324  DT.91924019 

    24/222 AceView cDNA sequences (see all 222):

    T09009 BM454592 BX399667 BU153716 BQ010148 CD677665 AA307893 BQ960028 
    BU631548 BQ775140 AA992570 BX495002 BQ269780 AF061016 AW961903 BM967111 
    BG194936 BM905099 BQ716941 BM459904 AI139310 BP376289 AU280160 BX952433 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UGDH (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                                                            
    SP2:                          -     -     -                                                                     
    SP3:                                                                                                            
    SP4:                          -                                                                                 
    SP5:                          -     -     -                                                                     


    ECgene alternative splicing isoforms for UGDH

    Expression
    for UGDH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATGGTCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UGDH expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbAutopodMesenchymal Condensate CellsBone, Cartilage
    LimbAutopod Synovial JointCentral Intermediate Lamina CellsCartilage
    LimbAutopod Synovial JointInterzone CellsCartilage
    LimbStylopodMesenchymal Condensate CellsBone, Cartilage
    LimbStylopod Synovial JointCentral Intermediate Lamina CellsCartilage
    LimbStylopod Synovial JointInterzone CellsCartilage
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    LimbZeugopod Synovial JointCentral Intermediate Lamina CellsCartilage
    LimbZeugopod Synovial JointInterzone CellsCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)

    See UGDH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGDH

    SOURCE GeneReport for Unigene cluster: Hs.572518

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Tissue specificity: Widely expressed

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    Orthologs
    for UGDH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UGDH gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ugdh1 , 5 UDP-glucose dehydrogenase1, 5 89.86(n)1
    97.97(a)1    		   5 (33.67 cM)5
    222351  NM_009466.21  NP_033492.11 
     654132025 
    chicken
    (Gallus gallus)    		 Aves UGDH1 UDP-glucose 6-dehydrogenase 82.25(n)
    93.72(a)    		   422792  NM_001012581.1  NP_001012599.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UGDH6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 5(99670123-99675748)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC525112 similar to UDP-glucose dehydrogenase 77.36(n)    AY014958.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ugdh2 UDP-glucose dehydrogenase 76.97(n)   116991  AF361478.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sgl1 , 3 mesoderm migration UDP-glucose
    6-dehydrogenase3
    sugarless1    		 68(a)3
    61.28(n)1
    69.21(a)1    		   3 65D53
    387601  NM_057632.31  NP_476980.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea sqv-41 Protein SQV-4 61.71(n)
    66.52(a)    		   179484  NM_073329.6  NP_505730.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UGD11 UDP-glucose dehydrogenase 1 61.23(n)
    63.04(a)    		   839197  NM_102419.3  NP_173979.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.104732 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.44(n)    AK105768.1 


    ENSEMBL Gene Tree for UGDH (if available)
    TreeFam Gene Tree for UGDH (if available) 

    Paralogs
    for UGDH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for UGDH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): UGDH
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGDH
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    Disorders / Diseases
    for UGDH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UGDH for disorders           About GeneDecksing

    OMIM gene information: 603370    OMIM disorders: --

    20 diseases for UGDH:    About MalaCards
    hypoxia    morbid obesity    rheumatoid arthritis    chordoma
    graves' disease    synovitis    arthritis    breast cancer
    hyperglycemia    obesity    pharyngitis    peritonitis
    prostate cancer    neuroblastoma    prostatitis    tuberculosis
    neuronitis    carcinoma    mycobacterium tuberculosis    alcoholism

    2 Novoseek disease relationships for UGDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 15.9 2 15059280 (1), 10068780 (1)
    breast cancer 0 4 10499502 (2), 16158268 (1)

    Human Genome Epidemiology (HuGE) Navigator: UGDH (1 document)

    Export disorders for UGDH gene to outside databases

    Publications
    for UGDH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGDH gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with UGDH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human and mouse UDP- glucose dehydrogenase genes. (PubMed id 9737970)1, 2, 3, 9 Spicer A.P.... Seldin M.F. (1998)
    2. cDNA cloning and expression analysis of the human UDPglucose dehydrogenase. (PubMed id 9850599)1, 2, 9 Peng H.L.... Chang H.Y. (1998)
    3. Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. (PubMed id 10575217)1, 3, 9 Marcu O....Marsh J.L. (1999)
    4. Structural and kinetic evidence that catalytic reactio n of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thio ester enzyme intermediates. (PubMed id 22123821)1, 2 Egger S....Nidetzky B. (2012)
    5. Structure and mechanism of human UDP-glucose 6-dehydr ogenase. (PubMed id 21502315)1, 2 Egger S....Nidetzky B. (2011)
    6. Conformational flexibility in the allosteric regulati on of human UDP-I+-D-glucose 6-dehydrogenase. (PubMed id 21961565)1, 2 Sennett N.C....Wood Z.A. (2011)
    7. Structural basis of cooperativity in human UDP-glucos e dehydrogenase. (PubMed id 21984906)1, 2 Rajakannan V....Robinson R.C. (2011)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase. (PubMed id 15247292)1, 9 Huh J.W....Cho S.W. (2004)

    External Searches for UGDH gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UGDH gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7358 HGNC: 12525 AceView: UGDH Ensembl:ENSG00000109814 euGenes: HUgn7358
    ECgene: UGDH Kegg: 7358 H-InvDB: UGDH

    Other Databases showing UGDH gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UGDH gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGDH Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UGDH gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UGDH gene:
    Search GeneIP for patents involving UGDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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