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UGDH Gene

protein-coding   GIFtS: 67
GCID: GC04M039502

UDP-Glucose 6-Dehydrogenase

(Previous name: UDP-glucose dehydrogenase)
  See UGDH-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP-Glucose 6-Dehydrogenase1 2     EC 1.1.1.223 8
UDPGDH2 3 5     GDH2
UDP-Glucose Dehydrogenase1 2     UGD2
UDP-GlcDH2 3     Uridine Diphospho-Glucose Dehydrogenase2
UDP-Glc Dehydrogenase2 3     

External Ids:    HGNC: 125251   Entrez Gene: 73582   Ensembl: ENSG000001098147   OMIM: 6033705   UniProtKB: O607013   

Export aliases for UGDH gene to outside databases

Previous GC identifers: GC04M039674 GC04M039335 GC04M039397 GC04M039322 GC04M039176 GC04M038825


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UGDH Gene:
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the
biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These
glycosylated compounds are common components of the extracellular matrix and likely play roles in signal
transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by
transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple
transcript variants.(provided by RefSeq, May 2010)

GeneCards Summary for UGDH Gene:
UGDH (UDP-glucose 6-dehydrogenase) is a protein-coding gene. Diseases associated with UGDH include hypoxia. GO annotations related to this gene include electron carrier activity and UDP-glucose 6-dehydrogenase activity.

UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate

Gene Wiki entry for UGDH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UGDH gene promoter:
         STAT1   Sp1   Egr-1   STAT1beta   CUTL1   HNF-1A   STAT1alpha   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUGDH promoter sequence
   Search Chromatin IP Primers for UGDH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UGDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.1   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

UGDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGDH gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M039502:  view genomic region     (about GC identifiers)

Start:
39,500,375 bp from pter      End:
39,529,931 bp from pter
Size:
29,557 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701 (See protein sequence)
Recommended Name: UDP-glucose 6-dehydrogenase  
Size: 494 amino acids; 55024 Da
Subunit: Homohexamer
Selected PDB 3D structures from and Proteopedia for UGDH (see all 9):
2Q3E (3D)        2QG4 (3D)        3ITK (3D)        3KHU (3D)        3PRJ (3D)        3PTZ (3D)    
Secondary accessions: B3KUU2 B4DN25 O60589
Alternative splicing: 3 isoforms:  O60701-1   O60701-2   O60701-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UGDH: NX_O60701

Explore proteomics data for UGDH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UGDH (O60701) (see all 18)
     EKSTVPV  PIYEPGL  RINAWNS  DRVLIGG 


    See UGDH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171629.1  NP_001171630.1  NP_003350.1  

    ENSEMBL proteins: 
     ENSP00000319501   ENSP00000422909   ENSP00000421757   ENSP00000426560   ENSP00000421954  
     ENSP00000425834   ENSP00000424059   ENSP00000424435   ENSP00000422603   ENSP00000422565  
     ENSP00000427708  
    Reactome Protein details: O60701

    UGDH Human Recombinant Protein Products:

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    Novus Biologicals UGDH Proteins
    Novus Biologicals UGDH Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UGDH
    Cloud-Clone Corp. Proteins for UGDH

     
    Search eBioscience for Proteins for UGDH 

    UGDH Antibody Products:

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    ThermoFisher Antibody for UGDH
    LSBio Antibodies in human, mouse, rat for UGDH

    UGDH Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UGDH
    Cloud-Clone Corp. CLIAs for UGDH
    Search eBioscience for ELISAs for UGDH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001732 UDP-Glc/GDP-Man_DH_N
     IPR008927 6-PGluconate_DH_C-like
     IPR014027 UDP-Glc/GDP-Man_DH_C
     IPR014026 UDP-Glc/GDP-Man_DH_dimer
     IPR028356 UDPglc_DH_euk

    Graphical View of Domain Structure for InterPro Entry O60701

    ProtoNet protein and cluster: O60701

    1 Blocks protein domain: IPB001732 UDP-glucose/GDP-mannose dehydrogenase

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family


    Find genes that share domains with UGDH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UGDH_HUMAN, O60701
    Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate
    Catalytic activity: UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH
    Enzyme regulation: UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch

         Genatlas biochemistry entry for UGDH:
    UDP-glucose dehydrogenase,converting UDP-glucose to UDP-glucuronate,involved in normal cell proliferation and
    migration,upregulated by androgens,playing a potentially important role in the control of sex steroid
    inactivation via glucuronidation in breast cancer cells

         Enzyme Number (IUBMB): EC 1.1.1.221 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003979UDP-glucose 6-dehydrogenase activity TAS--
    GO:0009055electron carrier activity TAS9737970
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0051287NAD binding IEA--
         
    Find genes that share ontologies with UGDH           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UGDH:
     Decreased number of cells in m 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ugdh):
     craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body 
     mortality/aging  normal  vision/eye 

    Find genes that share phenotypes with UGDH           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UGDH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UGDH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UGDH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UGDH

    miRNA
    Products:
        
    miRTarBase miRNAs that target UGDH:
    hsa-mir-9-5p (MIRT021343), hsa-mir-26b-5p (MIRT028832), hsa-mir-24-3p (MIRT030373), hsa-mir-16-5p (MIRT000913), hsa-mir-15a-5p (MIRT000914), hsa-mir-92a-3p (MIRT049509), hsa-mir-155-5p (MIRT020547), hsa-mir-335-5p (MIRT016763), hsa-mir-30a-5p (MIRT028401)

    Block miRNA regulation of human, mouse, rat UGDH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UGDH (see all 34):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-miR-3146 hsa-miR-548k hsa-miR-624* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidUGDH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat UGDH

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): UGDH (NM_003359)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGDH
    Addgene plasmids for UGDH 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for UGDH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGDH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with UGDH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UGDH About    
    See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.61
    Pentose and glucuronate interconversions0.61
    Ascorbate and aldarate metabolism0.61
    Starch and sucrose metabolism0.41
    2Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism
    UDP-D-xylose and UDP-D-glucuronate biosynthesis0.00
    colanic acid building blocks biosynthesis0.00
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Biological oxidations
    Biological oxidations0.56
    Glucuronidation0.00
    Phase II conjugation0.56
    Formation of the active cofactor, UDP-glucuronate0.00


    Find genes that share SuperPaths with UGDH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for UGDH
        Glucuronidation
    colanic acid building blocks biosynthesis
    UDP-D-xylose and UDP-D-glucuronate biosynthesis

    1 Reactome Pathway for UGDH
        Formation of the active cofactor, UDP-glucuronate


    5 Kegg Pathways  (Kegg details for UGDH):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Starch and sucrose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from
    UDP-alpha-D-glucose: step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UGDH
    Interactions:

        Search GeneGlobe Interaction Network for UGDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UGDH (O607012, 3 ENSP000003195014) via UniProtKB, MINT, STRING, and/or I2D (see all 73)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT3Q9NTG73, ENSP000003721914I2D: score=2 STRING: ENSP00000372191
    DHHO433233, ENSP000002669914I2D: score=1 STRING: ENSP00000266991
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    WNT4P567053, ENSP000002901674I2D: score=1 STRING: ENSP00000290167
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0006011UDP-glucose metabolic process TAS9737970
    GO:0006024glycosaminoglycan biosynthetic process TAS9737970
    GO:0006065UDP-glucuronate biosynthetic process TAS--
    GO:0006805xenobiotic metabolic process TAS--

    Find genes that share ontologies with UGDH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UGDH

    5 HMDB Compounds for UGDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Uridine diphosphate glucose(UPD)-glucose (see all 24)133-89-1--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for UGDH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 1472079 17016423 3804697

    Selected Novoseek inferred chemical compound relationships for UGDH gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 95.7 136 16453102 (5), 1777115 (4), 10336992 (3), 15044486 (3) (see all 63)
    udp glucuronic acid 94.8 35 2287590 (1), 7868856 (1), 12682078 (1), 16002992 (1) (see all 22)
    udpxylose 82.4 2 16453102 (1)
    glycosaminoglycan 63.9 9 18717819 (2), 12910476 (1), 9737970 (1), 16418163 (1) (see all 5)
    nad+ 54.1 5 15247292 (3), 15044486 (1)
    chondroitin 53.9 1 10806213 (1)
    chondroitin sulfate 51.9 6 2287590 (1), 8014943 (1)
    6-phosphogluconate 51.4 2 12196534 (1), 12604241 (1)
    methyl viologen 46.8 2 12526718 (1), 12673771 (1)
    hyaluronic acid 45 6 10068780 (2), 2287590 (1), 16023581 (1)



    Find genes that share compounds with UGDH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UGDH gene (3 alternative transcripts): 
    NM_001184700.1  NM_001184701.1  NM_003359.3  

    Unigene Cluster for UGDH:

    UDP-glucose 6-dehydrogenase
    Hs.572518  [show with all ESTs]
    Unigene Representative Sequence: NM_003359
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316423(uc003guk.2 uc011byp.2 uc003gul.2) ENST00000501493
    ENST00000506179 ENST00000507089 ENST00000515021 ENST00000514106 ENST00000510881
    ENST00000503779 ENST00000509391 ENST00000515398 ENST00000505698 ENST00000510490

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UGDH (see all 34):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-548j hsa-miR-379* hsa-miR-3146 hsa-miR-548k hsa-miR-624* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidUGDH 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UGDH
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): UGDH (NM_003359)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGDH
    Addgene plasmids for UGDH 
    Primer
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    OriGene qPCR primer pairs and template standards for UGDH
    OriGene qSTAR qPCR primer pairs in human, mouse for UGDH
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      QuantiTect SYBR Green Assays in human, mouse, rat UGDH
      QuantiFast Probe-based Assays in human, mouse, rat UGDH

    Additional mRNA sequence: 

    AF049126.1 AF061016.1 AJ007702.1 AK097930.1 AK297737.1 BC013430.1 BC022781.1 

    16 DOTS entries:

    DT.91770177  DT.95284989  DT.100753327  DT.102827162  DT.91770181  DT.121230260  DT.99934894  DT.100724687 
    DT.121230198  DT.121230261  DT.121230313  DT.95284980  DT.99967462  DT.121230308  DT.121230324  DT.91924019 

    Selected AceView cDNA sequences (see all 222):

    BQ269780 AA992570 BX399667 T09009 CD677665 BX495002 BU631548 BQ775140 
    BM454592 BQ010148 AA307893 BU153716 BQ960028 BI548597 AK097930 BM455182 
    BG203057 BQ231169 AW069277 BP352747 AU131705 AA454086 BP335707 CK818998 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UGDH (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                                                            
    SP2:                          -     -     -                                                                     
    SP3:                                                                                                            
    SP4:                          -                                                                                 
    SP5:                          -     -     -                                                                     


    ECgene alternative splicing isoforms for UGDH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    UGDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGGTCTGG
    UGDH Expression
    About this image


    UGDH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Limb (Muscoskeletal System)    fully expand to see all 9 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Membranous Facial Bones
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    UGDH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UGDH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.572518

    UniProtKB/Swiss-Prot: UGDH_HUMAN, O60701
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UGDH gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ugdh1 , 5 UDP-glucose dehydrogenase1, 5 89.86(n)1
    97.97(a)1
      5 (33.67 cM)5
    222351  NM_009466.21  NP_033492.11 
     654132025 
    chicken
    (Gallus gallus)
    Aves UGDH1 UDP-glucose 6-dehydrogenase 82.25(n)
    93.72(a)
      422792  NM_001012581.1  NP_001012599.1 
    lizard
    (Anolis carolinensis)
    Reptilia UGDH6
    UDP-glucose 6-dehydrogenase
    90(a)
    1 ↔ 1
    5(99670120-99676278)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525112 similar to UDP-glucose dehydrogenase 77.36(n)    AY014958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ugdh2 UDP-glucose dehydrogenase 76.97(n)   116991  AF361478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sgl1 , 3 mesoderm migration UDP-glucose
    6-dehydrogenase3
    sugarless1
    68(a)3
    61.28(n)1
    69.21(a)1
      3 65D53
    387601  NM_057632.41  NP_476980.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sqv-41 sqv-4 61.63(n)
    66.52(a)
      179484  NM_073329.7  NP_505730.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G393201 AT5G39320 60.45(n)
    63.16(a)
      833928  NM_123294.3  NP_198748.1 
    rice
    (Oryza sativa)
    Liliopsida Os.104732 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.44(n)    AK105768.1 


    ENSEMBL Gene Tree for UGDH (if available)
    TreeFam Gene Tree for UGDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UGDH gene
    2 SIMAP similar genes for UGDH using alignment to 8 protein entries:     UGDH_HUMAN (see all proteins):
    GDH    ugd

    Find genes that share paralogs with UGDH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UGDH (see all 603)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449902361,2
    C--38856225(+) CAAAAC/TGGTTA 3 -- us2k10--------
    rs1164642001,2
    F--39500063(+) CTGGCC/GTTAAG 3 -- ds5001 int11Minor allele frequency- G:0.01WA 118
    rs1490137071,2
    C--39500114(+) TGCATA/GAGCCA 3 -- ds5001 int10--------
    rs1130039771,2
    C,F--39500151(+) ATGACC/TATGTA 3 -- ds5001 int12Minor allele frequency- T:0.03NA 122
    rs119357511,2
    C,F,A,H--39500187(+) ACTCAT/CGGCTG 3 -- ds5001 int15Minor allele frequency- C:0.03NS EA NA 538
    rs757112861,2
    F--39500237(+) TTTGCT/CAAATT 3 -- ds5001 int11Minor allele frequency- C:0.01WA 118
    rs131354751,2
    C,F,A--39500244(+) AATTCT/CCTCCC 3 -- ds5001 int111Minor allele frequency- C:0.37NA CSA WA EA 510
    rs1438080391,2
    C--39500489(+) AGGATA/GAGACC 3 -- ut310--------
    rs14501,2
    C,F,A,H--39500514(+) CAAACT/CGTACA 3 -- ut3134Minor allele frequency- C:0.32MN NA NS EA 3644
    rs1817292451,2
    --39500516(+) AACTGA/TACATT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for UGDH (39500375 - 39529931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UGDH:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5527n71CNV Loss21882294
    nsv878942CNV Loss21882294
    nsv878946CNV Loss21882294
    nsv878943CNV Gain21882294

    Human Gene Mutation Database (HGMD): UGDH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UGDH
    DNA2.0 Custom Variant and Variant Library Synthesis for UGDH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603370    OMIM disorders: --

    1 disease for UGDH:    
    About MalaCards
    hypoxia


    Find genes that share disorders with UGDH           About GenesLikeMe

    2 Novoseek inferred disease relationships for UGDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 15.9 2 15059280 (1), 10068780 (1)
    breast cancer 0 4 10499502 (2), 16158268 (1)

    Genetic Association Database (GAD): UGDH
    Human Genome Epidemiology (HuGE) Navigator: UGDH (1 document)

    Export disorders for UGDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UGDH gene, integrated from 10 sources (see all 121):
    (articles sorted by number of sources associating them with UGDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human and mouse UDP- glucose dehydrogenase genes. (PubMed id 9737970)1, 2, 3, 9 Spicer A.P.... Seldin M.F. (J. Biol. Chem. 1998)
    2. cDNA cloning and expression analysis of the human UDPglucose dehydrogenase. (PubMed id 9850599)1, 2, 9 Peng H.L.... Chang H.Y. (Proc. Natl. Sci. Counc. Repub. China, B, Life Sci. 1998)
    3. Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. (PubMed id 10575217)1, 3, 9 Marcu O....Marsh J.L. (Cytogenet. Cell Genet. 1999)
    4. Structural and kinetic evidence that catalytic reaction of human UDP- glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates. (PubMed id 22123821)1, 2 Egger S....Nidetzky B. (J. Biol. Chem. 2012)
    5. Structure and mechanism of human UDP-glucose 6-dehydrogenase. (PubMed id 21502315)1, 2 Egger S.... Nidetzky B. (J. Biol. Chem. 2011)
    6. Conformational flexibility in the allosteric regulation of human UDP- alpha-D-glucose 6-dehydrogenase. (PubMed id 21961565)1, 2 Sennett N.C.... Wood Z.A. (Biochemistry 2011)
    7. Structural basis of cooperativity in human UDP-glucose dehydrogenase. (PubMed id 21984906)1, 2 Rajakannan V.... Robinson R.C. (PLoS ONE 2011)
    8. Genome-wide association identifies candidate genes that influence the human electroencephalogram. (PubMed id 20421487)1, 4 Hodgkinson C.A....Goldman D. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7358 HGNC: 12525 AceView: UGDH Ensembl:ENSG00000109814 euGenes: HUgn7358
    ECgene: UGDH Kegg: 7358 H-InvDB: UGDH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UGDH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UGDH gene:
    Search GeneIP for patents involving UGDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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