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Aliases for UGCG Gene

Aliases for UGCG Gene

  • UDP-Glucose Ceramide Glucosyltransferase 2 3 4
  • Glucosylceramide Synthase 2 3 4
  • GCS 3 4 6
  • UDP-Glucose:N-Acylsphingosine D-Glucosyltransferase 3 4
  • Ceramide Glucosyltransferase 2 3
  • EC 2.4.1.80 4
  • GLCT-1 4
  • GLCT1 3

External Ids for UGCG Gene

Summaries for UGCG Gene

Entrez Gene Summary for UGCG Gene

  • This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]

GeneCards Summary for UGCG Gene

UGCG (UDP-Glucose Ceramide Glucosyltransferase) is a Protein Coding gene. Diseases associated with UGCG include gangliosidosis. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include ceramide glucosyltransferase activity.

UniProtKB/Swiss-Prot for UGCG Gene

  • Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".

Gene Wiki entry for UGCG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGCG Gene

Genomics for UGCG Gene

Genomic Location for UGCG Gene

Start:
111,896,766 bp from pter
End:
111,935,369 bp from pter
Size:
38,604 bases
Orientation:
Plus strand

Genomic View for UGCG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGCG Gene

Proteins for UGCG Gene

  • Protein details for UGCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16739-CEGT_HUMAN
    Recommended name:
    Ceramide glucosyltransferase
    Protein Accession:
    Q16739
    Secondary Accessions:
    • Q5T258

    Protein attributes for UGCG Gene

    Size:
    394 amino acids
    Molecular mass:
    44854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UGCG Gene

Proteomics data for UGCG Gene at MOPED

Post-translational modifications for UGCG Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys44, Lys49, Lys57, Lys104, and Lys124

Other Protein References for UGCG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UGCG Gene

Domains for UGCG Gene

Gene Families for UGCG Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Protein Domains for UGCG Gene

UniProtKB/Swiss-Prot:

CEGT_HUMAN
Family:
  • Belongs to the glycosyltransferase 2 family.:
    • Q16739
genes like me logo Genes that share domains with UGCG: view

Function for UGCG Gene

Molecular function for UGCG Gene

GENATLAS Biochemistry: UDP-glucose-ceramide glycosyltransferase,catalyzing the first glycosylation step of glycosphingolipid synthesis
UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.
UniProtKB/Swiss-Prot Function: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".

Enzyme Numbers (IUBMB) for UGCG Gene

Gene Ontology (GO) - Molecular Function for UGCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008120 ceramide glucosyltransferase activity IEA --
genes like me logo Genes that share ontologies with UGCG: view
genes like me logo Genes that share phenotypes with UGCG: view

Animal Models for UGCG Gene

MGI Knock Outs for UGCG:

miRNA for UGCG Gene

miRTarBase miRNAs that target UGCG

No data available for Transcription Factor Targeting and HOMER Transcription for UGCG Gene

Localization for UGCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGCG Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGCG Gene COMPARTMENTS Subcellular localization image for UGCG gene
Compartment Confidence
golgi apparatus 5
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UGCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane TAS 8643456
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGCG: view

Pathways for UGCG Gene

genes like me logo Genes that share pathways with UGCG: view

Pathways by source for UGCG Gene

UniProtKB/Swiss-Prot Q16739-CEGT_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism

Gene Ontology (GO) - Biological Process for UGCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0006679 glucosylceramide biosynthetic process TAS 8643456
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006688 glycosphingolipid biosynthetic process TAS 8643456
GO:0008544 epidermis development TAS 9545298
genes like me logo Genes that share ontologies with UGCG: view

Compounds for UGCG Gene

(112) HMDB Compounds for UGCG Gene

Compound Synonyms Cas Number PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))
  • Sulfatide (d18:1/18:1(9Z))
Not Available

(1) Drugbank Compounds for UGCG Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Miglustat
72599-27-0 target inhibitor

(37) Novoseek inferred chemical compound relationships for UGCG Gene

Compound -log(P) Hits PubMed IDs
glucosylceramide 98.6 174
miglustat 94.3 23
pdmp 94.1 20
ceramide 92.6 131
glycosphingolipid 91.6 22
genes like me logo Genes that share compounds with UGCG: view

Transcripts for UGCG Gene

Unigene Clusters for UGCG Gene

UDP-glucose ceramide glucosyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGCG Gene

No ASD Table

Relevant External Links for UGCG Gene

GeneLoc Exon Structure for
UGCG
ECgene alternative splicing isoforms for
UGCG

Expression for UGCG Gene

mRNA expression in normal human tissues for UGCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGCG Gene

SOURCE GeneReport for Unigene cluster for UGCG Gene Hs.304249

mRNA Expression by UniProt/SwissProt for UGCG Gene

Q16739-CEGT_HUMAN
Tissue specificity: Found in all tissues examined.
genes like me logo Genes that share expressions with UGCG: view

Orthologs for UGCG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UGCG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGCG 36
  • 99.73 (n)
  • 100 (a)
UGCG 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGCG 36
  • 94.16 (n)
  • 99.75 (a)
UGCG 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UGCG 36
  • 95.01 (n)
  • 99.49 (a)
UGCG 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ugcg 36
  • 91.96 (n)
  • 98.22 (a)
Ugcg 16
Ugcg 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UGCG 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UGCG 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugcg 36
  • 89.93 (n)
  • 97.21 (a)
chicken
(Gallus gallus)
Aves UGCG 36
  • 84.26 (n)
  • 95.69 (a)
UGCG 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UGCG 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21362 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20419 36
ugcg 36
  • 81.22 (n)
  • 92.13 (a)
zebrafish
(Danio rerio)
Actinopterygii ugcg 36
  • 75.74 (n)
  • 90.84 (a)
ugcg 37
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012412 36
  • 57.63 (n)
  • 53.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta GlcT-1 36
  • 55.41 (n)
  • 53.61 (a)
GlcT-1 37
  • 47 (a)
OneToOne
CG6437 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea cgt-1 37
  • 33 (a)
OneToMany
cgt-2 37
  • 37 (a)
OneToMany
cgt-3 36
  • 54.69 (n)
  • 45.58 (a)
cgt-3 37
  • 37 (a)
OneToMany
F59G1.1c 38
  • 48 (a)
T06C12.10 38
  • 38 (a)
F59G1.1a 38
  • 44 (a)
F59G1.1b 38
  • 44 (a)
F20B4.6 38
  • 38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR207W 36
  • 40.17 (n)
  • 32.3 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02641g 36
  • 47.14 (n)
  • 34.7 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01116 36
  • 42.68 (n)
  • 33.14 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14730 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9756 37
  • 54 (a)
OneToOne
Species with no ortholog for UGCG:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UGCG Gene

ENSEMBL:
Gene Tree for UGCG (if available)
TreeFam:
Gene Tree for UGCG (if available)

Paralogs for UGCG Gene

No data available for Paralogs for UGCG Gene

Variants for UGCG Gene

Sequence variations from dbSNP and Humsavar for UGCG Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12143 -- 111,935,280(-) CACTG(G/T)TTTTT utr-variant-3-prime
rs12468 -- 111,933,479(+) CATGG(C/T)GAGGT downstream-variant-500B, utr-variant-3-prime
rs13913 -- 111,935,041(-) TTTTG(C/T)TGTTA utr-variant-3-prime
rs386621 -- 111,926,713(+) CTGTG(C/T)GCAGG intron-variant
rs454073 -- 111,911,989(-) tatat(A/G)tatcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGCG Gene

Variant ID Type Subtype PubMed ID
nsv831690 CNV Loss 17160897
nsv893729 CNV Gain 21882294
esv1136125 CNV Deletion 17803354

Relevant External Links for UGCG Gene

HapMap Linkage Disequilibrium report
UGCG

Disorders for UGCG Gene

(1) MalaCards Diseases for UGCG Gene

Search for UGCG Gene in MalaCards »

(3) University of Copenhagen DISEASES for UGCG Gene

(16) Novoseek inferred disease relationships for UGCG Gene

Disease -log(P) Hits PubMed IDs
type 1 gaucher disease 85.4 2
gaucher disease 73.8 5
neuroepithelioma 56.1 2
sandhoff disease 53 1
fabry disease 44.8 1

Relevant External Links for UGCG

Genetic Association Database (GAD)
UGCG
Human Genome Epidemiology (HuGE) Navigator
UGCG
genes like me logo Genes that share disorders with UGCG: view

No data available for UniProtKB/Swiss-Prot for UGCG Gene

Publications for UGCG Gene

  1. Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. (PMID: 8643456) Ichikawa S. … Hirabayashi Y. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization. (PMID: 9605861) Ichikawa S. … Hirabayashi Y. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. (PMID: 8901638) Ichikawa S. … Hirabayashi Y. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  4. Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens. (PMID: 10945987) Tepper A.D. … Borst J. (J. Biol. Chem. 2000) 3 23
  5. [Role of glucosylceramide synthase as negative regulator for ceramide]. (PMID: 11915344) Kohyama-Koganaya A. … Hirabayashi Y. (Tanpakushitsu Kakusan Koso 2002) 3 23

Products for UGCG Gene

Sources for UGCG Gene

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