Aliases for UFSP2 Gene
External Ids for UFSP2 Gene
Previous HGNC Symbols for UFSP2 Gene
Previous GeneCards Identifiers for UFSP2 Gene
Like ubiquitin (see MIM 191339), ubiquitin-fold modifier-1 (UFM1; MIM 610553) must be processed by a protease before it can conjugate with its target proteins. UFSP2 is a thiol protease that specifically processes the C terminus of UFM1 (Kang et al., 2007 [PubMed 17182609]).[supplied by OMIM, Oct 2009]
GeneCards Summary for UFSP2 Gene
UFSP2 (UFM1-Specific Peptidase 2) is a Protein Coding gene. Diseases associated with UFSP2 include hip dysplasia, beukes type. GO annotations related to this gene include thiolester hydrolase activity and ubiquitin-like protein-specific protease activity. An important paralog of this gene is UFSP1.
UniProtKB/Swiss-Prot for UFSP2 Gene
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.