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Aliases for UFSP2 Gene

Aliases for UFSP2 Gene

  • UFM1-Specific Peptidase 2 2 3
  • C4orf20 3 4 6
  • Chromosome 4 Open Reading Frame 20 2
  • Ufm1-Specific Protease 2 3
  • EC 3.4.22.- 4
  • EC 3.4.22 63
  • UfSP2 4

External Ids for UFSP2 Gene

Previous HGNC Symbols for UFSP2 Gene

  • C4orf20

Previous GeneCards Identifiers for UFSP2 Gene

  • GC04M186559
  • GC04M186321
  • GC04M182074

Summaries for UFSP2 Gene

Entrez Gene Summary for UFSP2 Gene

  • Like ubiquitin (see MIM 191339), ubiquitin-fold modifier-1 (UFM1; MIM 610553) must be processed by a protease before it can conjugate with its target proteins. UFSP2 is a thiol protease that specifically processes the C terminus of UFM1 (Kang et al., 2007 [PubMed 17182609]).[supplied by OMIM, Oct 2009]

GeneCards Summary for UFSP2 Gene

UFSP2 (UFM1-Specific Peptidase 2) is a Protein Coding gene. GO annotations related to this gene include thiolester hydrolase activity and ubiquitin-like protein-specific protease activity. An important paralog of this gene is UFSP1.

UniProtKB/Swiss-Prot for UFSP2 Gene

  • Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFSP2 Gene

Genomics for UFSP2 Gene

Regulatory Elements for UFSP2 Gene

Genomic Location for UFSP2 Gene

Start:
185,399,540 bp from pter
End:
185,425,985 bp from pter
Size:
26,446 bases
Orientation:
Minus strand

Genomic View for UFSP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UFSP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFSP2 Gene

Proteins for UFSP2 Gene

  • Protein details for UFSP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUQ7-UFSP2_HUMAN
    Recommended name:
    Ufm1-specific protease 2
    Protein Accession:
    Q9NUQ7
    Secondary Accessions:
    • Q6IA77
    • Q96FS3

    Protein attributes for UFSP2 Gene

    Size:
    469 amino acids
    Molecular mass:
    53261 Da
    Quaternary structure:
    • Interacts with DDRGK1 (By similarity). Interacts with TRIP4; deufmylates TRIP4 (PubMed:25219498).

neXtProt entry for UFSP2 Gene

Proteomics data for UFSP2 Gene at MOPED

Post-translational modifications for UFSP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UFSP2 Gene

Domains for UFSP2 Gene

Protein Domains for UFSP2 Gene

Suggested Antigen Peptide Sequences for UFSP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUQ7

UniProtKB/Swiss-Prot:

UFSP2_HUMAN :
  • Q9NUQ7
Family:
  • Belongs to the peptidase C78 family.
genes like me logo Genes that share domains with UFSP2: view

No data available for Gene Families for UFSP2 Gene

Function for UFSP2 Gene

Molecular function for UFSP2 Gene

UniProtKB/Swiss-Prot Function: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.

Enzyme Numbers (IUBMB) for UFSP2 Gene

Gene Ontology (GO) - Molecular Function for UFSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25219498
GO:0016790 thiolester hydrolase activity IMP 25219498
GO:0019783 ubiquitin-like protein-specific protease activity --
GO:0071567 UFM1 hydrolase activity IMP 25219498
genes like me logo Genes that share ontologies with UFSP2: view

Phenotypes for UFSP2 Gene

GenomeRNAi human phenotypes for UFSP2:
genes like me logo Genes that share phenotypes with UFSP2: view

miRNA for UFSP2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UFSP2 Gene

Localization for UFSP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UFSP2 Gene

Cytoplasm. Endoplasmic reticulum. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UFSP2 Gene COMPARTMENTS Subcellular localization image for UFSP2 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for UFSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with UFSP2: view

Pathways for UFSP2 Gene

SuperPathways for UFSP2 Gene

No Data Available

Interacting Proteins for UFSP2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264689%0d%0a9606.ENSP00000339404%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000287859%0d%0a
Selected Interacting proteins: ENSP00000264689 Q9NUQ7-UFSP2_HUMAN for UFSP2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for UFSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IMP 25219498
GO:0033146 regulation of intracellular estrogen receptor signaling pathway IMP 25219498
genes like me logo Genes that share ontologies with UFSP2: view

No data available for Pathways by source for UFSP2 Gene

Transcripts for UFSP2 Gene

Unigene Clusters for UFSP2 Gene

UFM1-specific peptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UFSP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2: -
SP3:

Relevant External Links for UFSP2 Gene

GeneLoc Exon Structure for
UFSP2
ECgene alternative splicing isoforms for
UFSP2

Expression for UFSP2 Gene

mRNA expression in normal human tissues for UFSP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UFSP2 Gene

SOURCE GeneReport for Unigene cluster for UFSP2 Gene Hs.713548

genes like me logo Genes that share expressions with UFSP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UFSP2 Gene

Orthologs for UFSP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFSP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UFSP2 35
  • 99.57 (n)
  • 100 (a)
UFSP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UFSP2 35
  • 90.76 (n)
  • 93.82 (a)
UFSP2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UFSP2 35
  • 90.5 (n)
  • 92.66 (a)
UFSP2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ufsp2 35
  • 83.66 (n)
  • 84.82 (a)
Ufsp2 16
Ufsp2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UFSP2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UFSP2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ufsp2 35
  • 84.09 (n)
  • 84.6 (a)
chicken
(Gallus gallus)
Aves UFSP2 35
  • 75.58 (n)
  • 76.09 (a)
UFSP2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UFSP2 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16099 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ufsp2 35
  • 68.25 (n)
  • 66.16 (a)
zebrafish
(Danio rerio)
Actinopterygii ufsp2 35
  • 63.1 (n)
  • 62.76 (a)
ufsp2 36
  • 58 (a)
OneToOne
wufb05c06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011975 35
  • 51.92 (n)
  • 50.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16979 35
  • 50.78 (n)
  • 48.91 (a)
CG16979 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea odr-8 36
  • 28 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.7568 35
rice
(Oryza sativa)
Liliopsida Os.7839 35
wheat
(Triticum aestivum)
Liliopsida Ta.9740 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.940 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for UFSP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UFSP2 Gene

ENSEMBL:
Gene Tree for UFSP2 (if available)
TreeFam:
Gene Tree for UFSP2 (if available)

Paralogs for UFSP2 Gene

Paralogs for UFSP2 Gene

Selected SIMAP similar genes for UFSP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with UFSP2: view

Variants for UFSP2 Gene

Sequence variations from dbSNP and Humsavar for UFSP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1060115 -- 185,408,220(-) TAGCC(A/C)TTAAT intron-variant
rs1545299 -- 185,412,329(-) GGCCA(A/T)CCAGC intron-variant
rs1562051 -- 185,407,345(-) CAGGT(A/G)CAGTG intron-variant
rs1992581 -- 185,419,709(+) tcact(C/T)agctt intron-variant
rs1992582 -- 185,419,723(+) gtttc(A/T)tctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UFSP2 Gene

Variant ID Type Subtype PubMed ID
nsv428456 CNV Gain+Loss 18775914
nsv881506 CNV Gain 21882294
dgv1724e1 CNV Complex 17122850
nsv527026 CNV Gain 19592680

Relevant External Links for UFSP2 Gene

HapMap Linkage Disequilibrium report
UFSP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UFSP2 Gene

Disorders for UFSP2 Gene

No disorders were found for UFSP2 Gene.

No data available for UniProtKB/Swiss-Prot for UFSP2 Gene

Publications for UFSP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. (PMID: 17182609) Kang S.H. … Chung C.H. (J. Biol. Chem. 2007) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development. (PMID: 25219498) Yoo H.M. … Chung C.H. (Mol. Cell 2014) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for UFSP2 Gene

Sources for UFSP2 Gene

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