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Aliases for UFSP1 Gene

Aliases for UFSP1 Gene

  • UFM1-Specific Peptidase 1 (Non-Functional) 2 3
  • Inactive Ufm1-Specific Protease 1 3
  • UfSP1 4
  • UFSP 3

External Ids for UFSP1 Gene

Summaries for UFSP1 Gene

Entrez Gene Summary for UFSP1 Gene

  • This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009]

GeneCards Summary for UFSP1 Gene

UFSP1 (UFM1-Specific Peptidase 1 (Non-Functional)) is a Protein Coding gene. GO annotations related to this gene include thiolester hydrolase activity and UFM1 hydrolase activity. An important paralog of this gene is UFSP2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFSP1 Gene

Genomics for UFSP1 Gene

Genomic Location for UFSP1 Gene

Start:
100,888,723 bp from pter
End:
100,889,718 bp from pter
Size:
996 bases
Orientation:
Minus strand

Genomic View for UFSP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UFSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFSP1 Gene

Regulatory Elements for UFSP1 Gene

Transcription factor binding sites by QIAGEN in the UFSP1 gene promoter:

Proteins for UFSP1 Gene

  • Protein details for UFSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NVU6-UFSP1_HUMAN
    Recommended name:
    Inactive Ufm1-specific protease 1
    Protein Accession:
    Q6NVU6
    Secondary Accessions:
    • A4D2E4
    • A8K8V2
    • B6ZDG6
    • Q9BXP6

    Protein attributes for UFSP1 Gene

    Size:
    142 amino acids
    Molecular mass:
    15060 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAL23814.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for UFSP1 Gene

Proteomics data for UFSP1 Gene at MOPED

Post-translational modifications for UFSP1 Gene

No Post-translational modifications

Other Protein References for UFSP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UFSP1 Gene

Domains for UFSP1 Gene

Protein Domains for UFSP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

UFSP1_HUMAN
Family:
  • Belongs to the peptidase C78 family.:
    • Q6NVU6
genes like me logo Genes that share domains with UFSP1: view

No data available for Gene Families for UFSP1 Gene

Function for UFSP1 Gene

Gene Ontology (GO) - Molecular Function for UFSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016790 thiolester hydrolase activity IBA --
GO:0071567 UFM1 hydrolase activity IBA --
genes like me logo Genes that share ontologies with UFSP1: view

Phenotypes for UFSP1 Gene

genes like me logo Genes that share phenotypes with UFSP1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UFSP1 Gene

Localization for UFSP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UFSP1 Gene COMPARTMENTS Subcellular localization image for UFSP1 gene
Compartment Confidence
cytosol 2
extracellular 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UFSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UFSP1: view

Pathways for UFSP1 Gene

SuperPathways for UFSP1 Gene

No Data Available

Interacting Proteins for UFSP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000373413%0d%0a9606.ENSP00000287859%0d%0a
Selected Interacting proteins: ENSP00000373413 for UFSP1 Gene via STRING

Symbol External ID(s) Details
C1orf27

Gene Ontology (GO) - Biological Process for UFSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with UFSP1: view

No data available for Pathways by source for UFSP1 Gene

Transcripts for UFSP1 Gene

mRNA/cDNA for UFSP1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UFSP1 Gene

UFM1-specific peptidase 1 (non-functional):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UFSP1 Gene

No ASD Table

Relevant External Links for UFSP1 Gene

GeneLoc Exon Structure for
UFSP1
ECgene alternative splicing isoforms for
UFSP1

Expression for UFSP1 Gene

mRNA expression in normal human tissues for UFSP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for UFSP1 Gene

SOURCE GeneReport for Unigene cluster for UFSP1 Gene Hs.534845

genes like me logo Genes that share expressions with UFSP1: view

Orthologs for UFSP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UFSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UFSP1 36
  • 99.3 (n)
  • 98.59 (a)
UFSP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UFSP1 36
  • 84.51 (n)
  • 86.62 (a)
UFSP1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UFSP1 36
  • 83.8 (n)
  • 83.1 (a)
mouse
(Mus musculus)
Mammalia Ufsp1 36
  • 81.03 (n)
  • 82.31 (a)
Ufsp1 16
Ufsp1 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 5 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102550903 36
  • 81.28 (n)
  • 80.77 (a)
lizard
(Anolis carolinensis)
Reptilia UFSP1 37
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ufsp1 37
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30157 37
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToOne
Species with no ortholog for UFSP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UFSP1 Gene

ENSEMBL:
Gene Tree for UFSP1 (if available)
TreeFam:
Gene Tree for UFSP1 (if available)

Paralogs for UFSP1 Gene

Paralogs for UFSP1 Gene

Selected SIMAP similar genes for UFSP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UFSP1: view

Variants for UFSP1 Gene

Sequence variations from dbSNP and Humsavar for UFSP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs148676511 -- 100,889,200(+) TGAGC(A/G)AGGCA reference, synonymous-codon
rs191455018 -- 100,889,352(+) CTGCA(G/T)AGTGC utr-variant-5-prime
rs199927605 -- 100,889,183(+) CCTGG(A/G)GCCCT reference, missense
rs369098327 -- 100,889,194(+) CCGAA(A/G)TGAGC reference, synonymous-codon
rs372681909 -- 100,889,237(+) AGTCC(C/T)GGGAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for UFSP1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv2119e1 CNV Complex 17122850
dgv7403n71 CNV Loss 21882294
nsv831073 CNV Loss 17160897
dgv7404n71 CNV Loss 21882294
dgv7405n71 CNV Loss 21882294

Relevant External Links for UFSP1 Gene

HapMap Linkage Disequilibrium report
UFSP1
Human Gene Mutation Database (HGMD)
UFSP1

Disorders for UFSP1 Gene

Relevant External Links for UFSP1

Genetic Association Database (GAD)
UFSP1
Human Genome Epidemiology (HuGE) Navigator
UFSP1
genes like me logo Genes that share disorders with UFSP1: view

No data available for UniProtKB/Swiss-Prot for UFSP1 Gene

Publications for UFSP1 Gene

  1. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PMID: 11239002) Wilson M.D. … Koop B.F. (Nucleic Acids Res. 2001) 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. (PMID: 17182609) Kang S.H. … Chung C.H. (J. Biol. Chem. 2007) 2 3
  5. Structural basis for Ufm1 processing by UfSP1. (PMID: 18321862) Ha B.H. … Kim E.E. (J. Biol. Chem. 2008) 2 3

Products for UFSP1 Gene

Sources for UFSP1 Gene

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