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Aliases for UFM1 Gene

Aliases for UFM1 Gene

  • Ubiquitin Fold Modifier 1 2 3 5
  • C13orf20 3 4
  • Chromosome 13 Open Reading Frame 20 2
  • Ubiquitin-Fold Modifier 1 3
  • BM-002 3

External Ids for UFM1 Gene

Previous HGNC Symbols for UFM1 Gene

  • C13orf20

Previous GeneCards Identifiers for UFM1 Gene

  • GC13P037822
  • GC13P038923
  • GC13P019722

Summaries for UFM1 Gene

Entrez Gene Summary for UFM1 Gene

  • UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008]

GeneCards Summary for UFM1 Gene

UFM1 (Ubiquitin Fold Modifier 1) is a Protein Coding gene. Diseases associated with UFM1 include Autosomal Recessive Cerebellar Ataxia.

UniProtKB/Swiss-Prot for UFM1 Gene

  • Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).

Gene Wiki entry for UFM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFM1 Gene

Genomics for UFM1 Gene

Regulatory Elements for UFM1 Gene

Enhancers for UFM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F038398 1.3 Ensembl ENCODE 11.5 +49.2 49230 0.8 OSR2 CEBPB BCL11B ZBTB20 UFM1 GC13P038385 GC13P038417
GH13F038394 0.2 ENCODE 11.5 +45.4 45445 1.3 PKNOX1 NRF1 JUN FEZF1 OSR2 JUND ZNF366 ZNF391 TRIM28 TCF7L2 UFM1 GC13P038385 GC13P038417
GH13F038348 0.8 ENCODE 7.5 +0.1 57 2.9 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 YY1 GLIS2 ELK1 SP3 UFM1 ENSG00000279025
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UFM1 on UCSC Golden Path with GeneCards custom track

Promoters for UFM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054927 30 2800 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 YY1 GLIS2 ELK1 SP3

Genomic Location for UFM1 Gene

Chromosome:
13
Start:
38,349,771 bp from pter
End:
38,363,619 bp from pter
Size:
13,849 bases
Orientation:
Plus strand

Genomic View for UFM1 Gene

Genes around UFM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UFM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UFM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFM1 Gene

Proteins for UFM1 Gene

  • Protein details for UFM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61960-UFM1_HUMAN
    Recommended name:
    Ubiquitin-fold modifier 1
    Protein Accession:
    P61960
    Secondary Accessions:
    • Q14346
    • Q5VXS0
    • Q6IAG6
    • Q9CPX2
    • Q9NZF2

    Protein attributes for UFM1 Gene

    Size:
    85 amino acids
    Molecular mass:
    9118 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UFM1 Gene

    Alternative splice isoforms for UFM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UFM1 Gene

Post-translational modifications for UFM1 Gene

  • Ubiquitination at Lys 19
  • Modification sites at PhosphoSitePlus

Other Protein References for UFM1 Gene

No data available for DME Specific Peptides for UFM1 Gene

Domains & Families for UFM1 Gene

Protein Domains for UFM1 Gene

Suggested Antigen Peptide Sequences for UFM1 Gene

Graphical View of Domain Structure for InterPro Entry

P61960

UniProtKB/Swiss-Prot:

UFM1_HUMAN :
  • Belongs to the UFM1 family.
Family:
  • Belongs to the UFM1 family.
genes like me logo Genes that share domains with UFM1: view

No data available for Gene Families for UFM1 Gene

Function for UFM1 Gene

Molecular function for UFM1 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).
UniProtKB/Swiss-Prot Induction:
Up-regulated by thapsigargin.

Gene Ontology (GO) - Molecular Function for UFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26872069
genes like me logo Genes that share ontologies with UFM1: view
genes like me logo Genes that share phenotypes with UFM1: view

Animal Model Products

miRNA for UFM1 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UFM1 Gene

Localization for UFM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UFM1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UFM1 Gene COMPARTMENTS Subcellular localization image for UFM1 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15071506
GO:0005737 cytoplasm IEA,IDA 15071506
GO:0005783 endoplasmic reticulum ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UFM1: view

Pathways & Interactions for UFM1 Gene

SuperPathways for UFM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033146 regulation of intracellular estrogen receptor signaling pathway IDA 25219498
GO:0034976 response to endoplasmic reticulum stress IDA 23152784
GO:0043066 negative regulation of apoptotic process ISS --
GO:0071569 protein ufmylation IDA 15071506
GO:1990592 protein K69-linked ufmylation IDA 25219498
genes like me logo Genes that share ontologies with UFM1: view

No data available for Pathways by source and SIGNOR curated interactions for UFM1 Gene

Transcripts for UFM1 Gene

Unigene Clusters for UFM1 Gene

Ubiquitin-fold modifier 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UFM1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for UFM1 Gene

GeneLoc Exon Structure for
UFM1
ECgene alternative splicing isoforms for
UFM1

Expression for UFM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UFM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UFM1 Gene

This gene is overexpressed in Oral epithelium (9.2) and Salivary gland (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UFM1 Gene



Protein tissue co-expression partners for UFM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UFM1 Gene:

UFM1

SOURCE GeneReport for Unigene cluster for UFM1 Gene:

Hs.643655
genes like me logo Genes that share expression patterns with UFM1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UFM1 Gene

Orthologs for UFM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UFM1 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia UFM1 34 35
  • 96.86 (n)
cow
(Bos Taurus)
Mammalia UFM1 34
  • 94.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UFM1 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ufm1 34 16 35
  • 89.8 (n)
rat
(Rattus norvegicus)
Mammalia Ufm1 34
  • 88.63 (n)
chicken
(Gallus gallus)
Aves UFM1 34 35
  • 84.71 (n)
lizard
(Anolis carolinensis)
Reptilia UFM1 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ufm1 34
  • 84.31 (n)
Str.1490 34
zebrafish
(Danio rerio)
Actinopterygii ufm1 34 35
  • 82.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta UFM1_ANOGA 34
  • 70.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34191 34 35
  • 69.88 (n)
worm
(Caenorhabditis elegans)
Secernentea ufm-1 35
  • 79 (a)
OneToOne
tag-277 34
  • 69.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77710 34
  • 69.44 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7864 34
rice
(Oryza sativa)
Liliopsida Os01g0962400 34
  • 66.27 (n)
Os.5520 34
corn
(Zea mays)
Liliopsida Zm.16801 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5990 35
  • 85 (a)
OneToOne
Species where no ortholog for UFM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UFM1 Gene

ENSEMBL:
Gene Tree for UFM1 (if available)
TreeFam:
Gene Tree for UFM1 (if available)

Paralogs for UFM1 Gene

Pseudogenes.org Pseudogenes for UFM1 Gene

genes like me logo Genes that share paralogs with UFM1: view

No data available for Paralogs for UFM1 Gene

Variants for UFM1 Gene

Sequence variations from dbSNP and Humsavar for UFM1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1011484 -- 38,348,675(+) TCAGT(A/T)GGCTG upstream-variant-2KB
rs1032753 -- 38,347,932(-) TTGTG(A/G)AGGGA upstream-variant-2KB
rs10507470 -- 38,355,963(+) AATTG(C/T)TGAAA intron-variant
rs111706170 -- 38,349,860(+) CACTA(A/G)AGGAA nc-transcript-variant, utr-variant-5-prime
rs111718532 -- 38,361,078(+) GATAA(A/T)TTTTT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UFM1 Gene

Variant ID Type Subtype PubMed ID
nsv561512 CNV loss 21841781

Variation tolerance for UFM1 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UFM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UFM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UFM1 Gene

Disorders for UFM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UFM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autosomal recessive cerebellar ataxia
- elite association - COSMIC cancer census association via MalaCards
Search UFM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UFM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UFM1
genes like me logo Genes that share disorders with UFM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UFM1 Gene

Publications for UFM1 Gene

  1. Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1. (PMID: 16527251) Sasakawa H. … Kato K. (Biochem. Biophys. Res. Commun. 2006) 3 4 22 64
  2. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PMID: 15071506) Komatsu M. … Tanaka K. (EMBO J. 2004) 2 3 4 64
  3. Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development. (PMID: 25219498) Yoo H.M. … Chung C.H. (Mol. Cell 2014) 3 4 64
  4. Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. (PMID: 23152784) Zhang Y. … Li H. (PLoS ONE 2012) 3 4 64
  5. A novel type of E3 ligase for the Ufm1 conjugation system. (PMID: 20018847) Tatsumi K. … Komatsu M. (J. Biol. Chem. 2010) 3 4 64

Products for UFM1 Gene

Sources for UFM1 Gene

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