UFM1 Gene
protein-coding GIFtS: 51
GCID: GC13P038923
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ubiquitin-fold modifier 1(Previous name: chromosome 13 open reading frame 20 )
(Previous symbol: C13orf20)
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Aliases
for UFM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Fold Modifier 11 2 | | C13orf201 2 3 | | BA131P10.11 | | Chromosome 13 Open Reading Frame 201 | | BM-0022 |
Export aliases for UFM1 gene to outside databasesPrevious GC identifers: GC13P037822 GC13P019722 |
Summaries
for UFM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UFM1:
UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM603173) (Komatsu et al., 2004 (PubMed 15071506)).(supplied by OMIM, Dec 2008)
UniProtKB/Swiss-Prot: UFM1_HUMAN, P61960Function: Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1
Gene Wiki entry for UFM1
|
Genomic Views
for UFM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UFM1 gene promoter:
LHX3b/Lhx3b ATF-2 HNF-1A MEF-2A PPAR-gamma1 HNF-1 LHX3a/Lhx3a c-Jun PPAR-gamma2 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for UFM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UFM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q13.3 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q13.3UFM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P038923: view genomic region
(about GC identifiers)
Start:
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38,923,942 bp from pter |
End:
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38,937,143 bp from pter |
Size:
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13,202 bases |
Orientation:
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plus strand |
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Proteins
for UFM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UFM1_HUMAN, P61960 (See
protein sequence)Recommended Name: Ubiquitin-fold modifier 1 precursor Size: 85 amino acids; 9118 Da
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear. Also expressed diffusely in the cytoplasm
1 PDB 3D structure from  and Proteopedia  for UFM1:1WXS (3D)
Secondary accessions: Q14346 Q5VXS0 Q6IAG6 Q9CPX2 Q9NZF2Alternative splicing: 2 isoforms: P61960-1 P61960-2 Explore the universe of human proteins at neXtProt for UFM1: NX_P61960
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P61960
UFM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057701.1
ENSEMBL proteins: ENSP00000368970 ENSP00000239878 ENSP00000402378 ENSP00000368962
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
UFM1 for ontologies About GeneDecksing
UFM1 Antibody Products:
Assay Products for UFM1: |
Protein
Domains /
Families
for UFM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UFM1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P61960ProtoNet protein and cluster: P61960 1 Blocks protein family: IPB005375 Protein of unknown function UPF0185
UniProtKB/Swiss-Prot: UFM1_HUMAN, P61960Similarity: Belongs to the UFM1 family |
Function
for UFM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UFM1_HUMAN, P61960Function: Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UFM1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UFM1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UFM1 (NM_016617) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UFM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFM1 |
1 GenomeRNAi human phenotype for UFM1:
|
Pathways & Interactions
for UFM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UFM1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/19 Interacting proteins for UFM1 (P619601, 2, 3 ENSP000002398784) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
UFM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UFM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UFM1
Search CenterWatch for drugs/clinical trials and news about UFM1
|
Transcripts
for UFM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UFM1 gene: NM_016617.2 Unigene Cluster for UFM1: Ubiquitin-fold modifier 1 Hs.643655 [show with all ESTs]Unigene Representative Sequence: NM_0166176 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000494372 ENST00000379649(uc010aca.2) ENST00000239878(uc001uwu.3)
ENST00000464423 ENST00000437952(uc010abz.2) ENST00000379641
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UFM1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UFM1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UFM1 (NM_016617) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UFM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFM1 |
Additional cDNA sequence: AB154404.1 AF208844.1 AF305827.2 AF369953.1 AK095490.1 AK307111.1 AK309914.1 BC005193.1 CR457189.1 Z70222.1 20 DOTS entries: DT.92442455 DT.100793892 DT.120782889 DT.91994466 DT.92442457 DT.100650864 DT.428877 DT.100793894 DT.100793891 DT.92442460 DT.92442462 DT.99953251 DT.120782865 DT.120782891 DT.92442456 DT.92442458 DT.92442459 DT.120782856 DT.92442465 DT.95152933 24/327 AceView cDNA sequences (see all 327): AA339642 AL600755 AA452076 AA766135 AA677539 AI073905 AA736845 BU069122 BM683574 AA362012 AI393910 CB070175 W52289 CA773783 AA628783 CA395682 F12644 AA747909 AI371710 AL537540 CK429252 CR457189 AB154404 BP343753
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UFM1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 |
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| SP1: | | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for UFM1
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Expression
for UFM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UFM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTATATT
About this image
See UFM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UFM1
SOURCE GeneReport for Unigene cluster: Hs.643655
SABiosciences Custom PCR Arrays for UFM1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UFM1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat UFM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UFM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UFM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFM1 |
Orthologs
for UFM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UFM1 gene from 9/30 species (see all 30) About this table
ENSEMBL Gene Tree for UFM1 (if available)
TreeFam Gene Tree for UFM1 (if available) |
Paralogs
for UFM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UFM1 gene
UFM1 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for UFM1
PGOHUM00000237031 PGOHUM00000241016 PGOHUM00000249456 PGOHUM00000242061
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Genomic Variants
for UFM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UFM1 (38923942 - 38937143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UFM1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UFM1 |
|
Disorders
/ Diseases
for UFM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 UFM1 for disorders About MalaCards
UFM1 for disorders About GeneDecksing
OMIM gene information: 610553
OMIM disorders: --
Export disorders for UFM1 gene to outside databases
|
Publications
for UFM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UFM1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with UFM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PubMed id 15071506)1, 2, 3 Komatsu M.... Tanaka K. (2004)
- Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1. (PubMed id 16527251)1, 2, 9 Sasakawa H.... Kato K. (2006)
- A novel type of E3 ligase for the Ufm1 conjugation system. (PubMed id 20018847)1, 2 Tatsumi K.... Komatsu M. (2010)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
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External Searches for UFM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UFM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UFM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UFM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UFM1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for UFM1 gene:
Search GeneIP for patents involving UFM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UFM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for UFM1 | | OriGene shRNA RFP for UFM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UFM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UFM1 | | | OriGene Protein Over-expression Lysate for UFM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UFM1 | | OriGene 3'-UTR Clone for UFM1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UFM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UFM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UFM1 | | OriGene Custom Protein Services for UFM1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UFM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UFM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UFM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UFM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UFM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UFM1 |
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 |  |  |  | |
| | | | Search Tocris compounds for UFM1 |
| |  |  |  |  | | | | | | Recombinant Protein for UFM1 |
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 | | | UFM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFM1 |
|  |  |  | | | | ThermoFisher Antibodies for UFM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFM1 |
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