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Aliases for UFM1 Gene

Aliases for UFM1 Gene

  • Ubiquitin-Fold Modifier 1 2 3
  • C13orf20 3 4
  • Chromosome 13 Open Reading Frame 20 2
  • BM-002 3

External Ids for UFM1 Gene

Previous HGNC Symbols for UFM1 Gene

  • C13orf20

Previous GeneCards Identifiers for UFM1 Gene

  • GC13P037822
  • GC13P038923
  • GC13P019722

Summaries for UFM1 Gene

Entrez Gene Summary for UFM1 Gene

  • UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008]

GeneCards Summary for UFM1 Gene

UFM1 (Ubiquitin-Fold Modifier 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for UFM1 Gene

  • Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (By similarity).

Gene Wiki entry for UFM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFM1 Gene

Genomics for UFM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UFM1 Gene

Start:
38,349,771 bp from pter
End:
38,363,619 bp from pter
Size:
13,849 bases
Orientation:
Plus strand

Genomic View for UFM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UFM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFM1 Gene

Proteins for UFM1 Gene

  • Protein details for UFM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61960-UFM1_HUMAN
    Recommended name:
    Ubiquitin-fold modifier 1
    Protein Accession:
    P61960
    Secondary Accessions:
    • Q14346
    • Q5VXS0
    • Q6IAG6
    • Q9CPX2
    • Q9NZF2

    Protein attributes for UFM1 Gene

    Size:
    85 amino acids
    Molecular mass:
    9118 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UFM1 Gene

    Alternative splice isoforms for UFM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UFM1 Gene

Proteomics data for UFM1 Gene at MOPED

Post-translational modifications for UFM1 Gene

  • Ubiquitination at Lys19
  • Modification sites at PhosphoSitePlus

Other Protein References for UFM1 Gene

No data available for DME Specific Peptides for UFM1 Gene

Domains for UFM1 Gene

Protein Domains for UFM1 Gene

Suggested Antigen Peptide Sequences for UFM1 Gene

Graphical View of Domain Structure for InterPro Entry

P61960

UniProtKB/Swiss-Prot:

UFM1_HUMAN :
  • P61960
Family:
  • Belongs to the UFM1 family.
genes like me logo Genes that share domains with UFM1: view

No data available for Gene Families for UFM1 Gene

Function for UFM1 Gene

Molecular function for UFM1 Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (By similarity).

Phenotypes for UFM1 Gene

GenomeRNAi human phenotypes for UFM1:
genes like me logo Genes that share phenotypes with UFM1: view

Animal Model Products

CRISPR Products

miRNA for UFM1 Gene

miRTarBase miRNAs that target UFM1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for UFM1 Gene

Localization for UFM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UFM1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UFM1 Gene COMPARTMENTS Subcellular localization image for UFM1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 2
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15071506
GO:0005737 cytoplasm IDA 15071506
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UFM1: view

Pathways for UFM1 Gene

SuperPathways for UFM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033146 regulation of intracellular estrogen receptor signaling pathway IDA 25219498
GO:0034976 response to endoplasmic reticulum stress IDA 23152784
GO:0071569 protein ufmylation IDA 15071506
GO:1990564 protein polyufmylation IDA 25219498
genes like me logo Genes that share ontologies with UFM1: view

No data available for Pathways by source for UFM1 Gene

Transcripts for UFM1 Gene

Unigene Clusters for UFM1 Gene

Ubiquitin-fold modifier 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UFM1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UFM1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for UFM1 Gene

GeneLoc Exon Structure for
UFM1
ECgene alternative splicing isoforms for
UFM1

Expression for UFM1 Gene

mRNA expression in normal human tissues for UFM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UFM1 Gene

SOURCE GeneReport for Unigene cluster for UFM1 Gene Hs.643655

genes like me logo Genes that share expressions with UFM1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UFM1 Gene

Orthologs for UFM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UFM1 35
  • 100 (n)
  • 100 (a)
UFM1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UFM1 35
  • 94.51 (n)
  • 98.82 (a)
dog
(Canis familiaris)
Mammalia UFM1 35
  • 96.86 (n)
  • 100 (a)
UFM1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ufm1 35
  • 89.8 (n)
  • 100 (a)
Ufm1 16
Ufm1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UFM1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ufm1 35
  • 88.63 (n)
  • 98.82 (a)
chicken
(Gallus gallus)
Aves UFM1 35
  • 84.71 (n)
  • 95.29 (a)
UFM1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UFM1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1490 35
ufm1 35
  • 84.31 (n)
  • 94.12 (a)
zebrafish
(Danio rerio)
Actinopterygii ufm1 35
  • 82.33 (n)
  • 98.8 (a)
ufm1 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta UFM1_ANOGA 35
  • 70.73 (n)
  • 89.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34191 35
  • 69.88 (n)
  • 87.95 (a)
CG34191 36
  • 84 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-277 35
  • 69.11 (n)
  • 90.24 (a)
ufm-1 36
  • 79 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7864 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77710 35
  • 69.44 (n)
  • 83.33 (a)
corn
(Zea mays)
Liliopsida Zm.16801 35
rice
(Oryza sativa)
Liliopsida Os.5520 35
Os01g0962400 35
  • 66.27 (n)
  • 82.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5990 36
  • 85 (a)
OneToOne
Species with no ortholog for UFM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UFM1 Gene

ENSEMBL:
Gene Tree for UFM1 (if available)
TreeFam:
Gene Tree for UFM1 (if available)

Paralogs for UFM1 Gene

Pseudogenes.org Pseudogenes for UFM1 Gene

genes like me logo Genes that share paralogs with UFM1: view

No data available for Paralogs for UFM1 Gene

Variants for UFM1 Gene

Sequence variations from dbSNP and Humsavar for UFM1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs11693 -- 38,362,951(+) CATGC(A/G)TTATT utr-variant-3-prime, nc-transcript-variant
rs950556 -- 38,352,830(-) AGACT(C/T)GGAAA intron-variant
rs1011484 -- 38,348,675(+) TCAGT(A/T)GGCTG upstream-variant-2KB
rs1032753 -- 38,347,932(-) TTGTG(A/G)AGGGA upstream-variant-2KB
rs1330959 -- 38,350,749(+) GTAGC(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UFM1 Gene

Variant ID Type Subtype PubMed ID
nsv900005 CNV Loss 21882294
nsv900006 CNV Loss 21882294

Relevant External Links for UFM1 Gene

HapMap Linkage Disequilibrium report
UFM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UFM1 Gene

Disorders for UFM1 Gene

No disorders were found for UFM1 Gene.

No data available for UniProtKB/Swiss-Prot for UFM1 Gene

Publications for UFM1 Gene

  1. Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1. (PMID: 16527251) Sasakawa H. … Kato K. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  2. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PMID: 15071506) Komatsu M. … Tanaka K. (EMBO J. 2004) 2 3 4
  3. Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development. (PMID: 25219498) Yoo H.M. … Chung C.H. (Mol. Cell 2014) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 4

Products for UFM1 Gene

Sources for UFM1 Gene

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