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Aliases for UFL1 Gene

Aliases for UFL1 Gene

  • UFM1-Specific Ligase 1 2 3
  • KIAA0776 2 3 4 6
  • Novel LZAP-Binding Protein 2 3 4
  • NLBP 3 4 6
  • Regulator Of CDK5RAP3 And DDRGK1 2 3
  • Regulator Of C53/LZAP And DDRGK1 3 4
  • RCAD 3 4
  • E3 UFM1-Protein Ligase 1 3
  • LZAP-Binding Protein 3
  • EC 6.3.2.- 4
  • Maxer 3

External Ids for UFL1 Gene

Previous HGNC Symbols for UFL1 Gene

  • KIAA0776

Previous GeneCards Identifiers for UFL1 Gene

  • GC06P096969

Summaries for UFL1 Gene

GeneCards Summary for UFL1 Gene

UFL1 (UFM1-Specific Ligase 1) is a Protein Coding gene. GO annotations related to this gene include UFM1 transferase activity.

UniProtKB/Swiss-Prot for UFL1 Gene

  • E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFL1 Gene

Genomics for UFL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UFL1 Gene

Start:
96,521,595 bp from pter
End:
96,555,276 bp from pter
Size:
33,682 bases
Orientation:
Plus strand

Genomic View for UFL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFL1 Gene

No data available for Regulatory Elements for UFL1 Gene

Proteins for UFL1 Gene

  • Protein details for UFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94874-UFL1_HUMAN
    Recommended name:
    E3 UFM1-protein ligase 1
    Protein Accession:
    O94874
    Secondary Accessions:
    • A0PJ53
    • B4DJ57
    • C0H5X5
    • Q8N765
    • Q9NTQ0

    Protein attributes for UFL1 Gene

    Size:
    794 amino acids
    Molecular mass:
    89595 Da
    Quaternary structure:
    • Interacts with DDRGK1 (PubMed:20018847, PubMed:20164180, PubMed:25219498). Interacts with UFC1 (PubMed:20018847). Interacts with RELA (PubMed:20164180). Interacts with TRIP4 (PubMed:25219498). Interacts with CDK5RAP3; the interaction is direct (PubMed:20164180, PubMed:20228063).
    SequenceCaution:
    • Sequence=AAH15377.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA34496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for UFL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UFL1 Gene

Proteomics data for UFL1 Gene at MOPED

Post-translational modifications for UFL1 Gene

  • Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome.
  • Ubiquitination at Lys43
  • Modification sites at PhosphoSitePlus

Other Protein References for UFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UFL1 Gene

Domains for UFL1 Gene

Protein Domains for UFL1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O94874

UniProtKB/Swiss-Prot:

UFL1_HUMAN :
  • O94874
Family:
  • Belongs to the UFL1 family.
genes like me logo Genes that share domains with UFL1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for UFL1 Gene

Function for UFL1 Gene

Molecular function for UFL1 Gene

UniProtKB/Swiss-Prot Function:
E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498).

Enzyme Numbers (IUBMB) for UFL1 Gene

Gene Ontology (GO) - Molecular Function for UFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20018847
GO:0016874 ligase activity IEA --
GO:0071568 UFM1 transferase activity IDA 20018847
genes like me logo Genes that share ontologies with UFL1: view

Phenotypes for UFL1 Gene

MGI mutant phenotypes for UFL1:
inferred from 1 alleles
GenomeRNAi human phenotypes for UFL1:
genes like me logo Genes that share phenotypes with UFL1: view

Animal Model Products

miRNA for UFL1 Gene

miRTarBase miRNAs that target UFL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UFL1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UFL1 Gene

Localization for UFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UFL1 Gene

Endoplasmic reticulum. Cytoplasm, cytosol.

Gene Ontology (GO) - Cellular Components for UFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IDA 20531390
genes like me logo Genes that share ontologies with UFL1: view

No data available for Subcellular locations from COMPARTMENTS for UFL1 Gene

Pathways for UFL1 Gene

SuperPathways for UFL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0008284 positive regulation of cell proliferation IMP 20531390
GO:0031397 negative regulation of protein ubiquitination IDA 20164180
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 20164180
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 20228063
genes like me logo Genes that share ontologies with UFL1: view

No data available for Pathways by source for UFL1 Gene

Transcripts for UFL1 Gene

mRNA/cDNA for UFL1 Gene

Unigene Clusters for UFL1 Gene

UFM1-specific ligase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UFL1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UFL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for UFL1 Gene

GeneLoc Exon Structure for
UFL1
ECgene alternative splicing isoforms for
UFL1

Expression for UFL1 Gene

mRNA expression in normal human tissues for UFL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UFL1 Gene

This gene is overexpressed in Bone (20.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UFL1 Gene

SOURCE GeneReport for Unigene cluster for UFL1 Gene Hs.149367

mRNA Expression by UniProt/SwissProt for UFL1 Gene

O94874-UFL1_HUMAN
Tissue specificity: Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC.
genes like me logo Genes that share expressions with UFL1: view

Expression partners for UFL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UFL1 Gene

Orthologs for UFL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UFL1 35
  • 91.2 (n)
  • 92.93 (a)
UFL1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UFL1 35
  • 92.25 (n)
  • 93.88 (a)
UFL1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ufl1 35
  • 87.01 (n)
  • 90.67 (a)
Ufl1 16
Ufl1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UFL1 35
  • 99.75 (n)
  • 99.62 (a)
UFL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ufl1 35
  • 87.1 (n)
  • 90.79 (a)
oppossum
(Monodelphis domestica)
Mammalia UFL1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves UFL1 35
  • 75.76 (n)
  • 75.76 (a)
UFL1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UFL1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ufl1 35
  • 69.14 (n)
  • 68.51 (a)
zebrafish
(Danio rerio)
Actinopterygii ufl1 35
  • 60.94 (n)
  • 63.21 (a)
zgc63562 35
ufl1 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3579 35
African malaria mosquito
(Anopheles gambiae)
Insecta UFL1_ANOGA 35
  • 45.01 (n)
  • 34.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1104 35
  • 46.61 (n)
  • 36.4 (a)
CG1104 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ufl-1 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G46220 35
  • 43.28 (n)
  • 27.62 (a)
rice
(Oryza sativa)
Liliopsida Os05g0117600 35
  • 43.69 (n)
  • 29.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for UFL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UFL1 Gene

ENSEMBL:
Gene Tree for UFL1 (if available)
TreeFam:
Gene Tree for UFL1 (if available)

Paralogs for UFL1 Gene

No data available for Paralogs for UFL1 Gene

Variants for UFL1 Gene

Sequence variations from dbSNP and Humsavar for UFL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1043252 -- 96,554,529(+) CAAAT(G/T)AATTT utr-variant-3-prime
rs1127175 -- 96,551,849(+) GAAGA(C/T)TTTAT reference, synonymous-codon
rs2255552 -- 96,551,767(+) AAACA(A/G)TTGTT intron-variant
rs2475023 -- 96,548,957(+) TTACA(A/G)AATTA intron-variant
rs2475024 -- 96,551,344(+) CTCAG(C/G)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UFL1 Gene

Variant ID Type Subtype PubMed ID
nsv886424 CNV Loss 21882294

Relevant External Links for UFL1 Gene

HapMap Linkage Disequilibrium report
UFL1
Human Gene Mutation Database (HGMD)
UFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UFL1 Gene

Disorders for UFL1 Gene

No disorders were found for UFL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for UFL1 Gene

Publications for UFL1 Gene

  1. A novel type of E3 ligase for the Ufm1 conjugation system. (PMID: 20018847) Tatsumi K. … Komatsu M. (J. Biol. Chem. 2010) 2 3 4
  2. A novel LZAP-binding protein, NLBP, inhibits cell invasion. (PMID: 20164180) Kwon J. … Kim H. (J. Biol. Chem. 2010) 2 3 4
  3. A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. (PMID: 20228063) Wu J. … Li H. (J. Biol. Chem. 2010) 2 3 4
  4. Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. (PMID: 20531390) Shiwaku H. … Okazawa H. (EMBO J. 2010) 2 3
  5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for UFL1 Gene

Sources for UFL1 Gene

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