Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UFL1 Gene

Aliases for UFL1 Gene

  • UFM1 Specific Ligase 1 2 3
  • Novel LZAP-Binding Protein 2 3 4
  • UFM1-Specific Ligase 1 2 3 5
  • KIAA0776 2 3 4
  • Regulator Of CDK5RAP3 And DDRGK1 2 3
  • Regulator Of C53/LZAP And DDRGK1 3 4
  • RCAD 3 4
  • NLBP 3 4
  • LZAP-Binding Protein 3
  • EC 6.3.2.- 4
  • Maxer 3

External Ids for UFL1 Gene

Previous HGNC Symbols for UFL1 Gene

  • KIAA0776

Previous GeneCards Identifiers for UFL1 Gene

  • GC06P096969

Summaries for UFL1 Gene

GeneCards Summary for UFL1 Gene

UFL1 (UFM1 Specific Ligase 1) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and UFM1 transferase activity.

UniProtKB/Swiss-Prot for UFL1 Gene

  • E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFL1 Gene

Genomics for UFL1 Gene

Regulatory Elements for UFL1 Gene

Enhancers for UFL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UFL1 on UCSC Golden Path with GeneCards custom track

Promoters for UFL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UFL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UFL1 Gene

Chromosome:
6
Start:
96,521,595 bp from pter
End:
96,555,276 bp from pter
Size:
33,682 bases
Orientation:
Plus strand

Genomic View for UFL1 Gene

Genes around UFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFL1 Gene

Proteins for UFL1 Gene

  • Protein details for UFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94874-UFL1_HUMAN
    Recommended name:
    E3 UFM1-protein ligase 1
    Protein Accession:
    O94874
    Secondary Accessions:
    • A0PJ53
    • B4DJ57
    • C0H5X5
    • Q8N765
    • Q9NTQ0

    Protein attributes for UFL1 Gene

    Size:
    794 amino acids
    Molecular mass:
    89595 Da
    Quaternary structure:
    • Interacts with DDRGK1 (PubMed:20018847, PubMed:20164180, PubMed:25219498). Interacts with UFC1 (PubMed:20018847). Interacts with RELA (PubMed:20164180). Interacts with TRIP4 (PubMed:25219498). Interacts with CDK5RAP3; the interaction is direct (PubMed:20164180, PubMed:20228063).
    SequenceCaution:
    • Sequence=AAH15377.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA34496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for UFL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UFL1 Gene

Proteomics data for UFL1 Gene at MOPED

Post-translational modifications for UFL1 Gene

  • Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome.
  • Ubiquitination at Lys 43
  • Modification sites at PhosphoSitePlus

Other Protein References for UFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UFL1 Gene

Domains & Families for UFL1 Gene

Protein Domains for UFL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94874

UniProtKB/Swiss-Prot:

UFL1_HUMAN :
  • Belongs to the UFL1 family.
Family:
  • Belongs to the UFL1 family.
genes like me logo Genes that share domains with UFL1: view

No data available for Gene Families for UFL1 Gene

Function for UFL1 Gene

Molecular function for UFL1 Gene

UniProtKB/Swiss-Prot Function:
E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784).
UniProtKB/Swiss-Prot Induction:
Up-regulated by thapsigargin.

Enzyme Numbers (IUBMB) for UFL1 Gene

Gene Ontology (GO) - Molecular Function for UFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UFL1: view
genes like me logo Genes that share phenotypes with UFL1: view

Animal Models for UFL1 Gene

MGI Knock Outs for UFL1:
  • Ufl1 tm1a(EUCOMM)Wtsi

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UFL1 Gene

Localization for UFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UFL1 Gene

Endoplasmic reticulum. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UFL1 Gene COMPARTMENTS Subcellular localization image for UFL1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5

Gene Ontology (GO) - Cellular Components for UFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with UFL1: view

Pathways & Interactions for UFL1 Gene

genes like me logo Genes that share pathways with UFL1: view

Gene Ontology (GO) - Biological Process for UFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 20164180
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 20228063
GO:0034976 response to endoplasmic reticulum stress IDA 23152784
GO:1902065 response to L-glutamate IEA --
genes like me logo Genes that share ontologies with UFL1: view

No data available for SIGNOR curated interactions for UFL1 Gene

Drugs & Compounds for UFL1 Gene

No Compound Related Data Available

Transcripts for UFL1 Gene

mRNA/cDNA for UFL1 Gene

Unigene Clusters for UFL1 Gene

UFM1-specific ligase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UFL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for UFL1 Gene

GeneLoc Exon Structure for
UFL1
ECgene alternative splicing isoforms for
UFL1

Expression for UFL1 Gene

mRNA expression in normal human tissues for UFL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UFL1 Gene

This gene is overexpressed in Bone (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UFL1 Gene



SOURCE GeneReport for Unigene cluster for UFL1 Gene Hs.149367

mRNA Expression by UniProt/SwissProt for UFL1 Gene

O94874-UFL1_HUMAN
Tissue specificity: Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC.
genes like me logo Genes that share expression patterns with UFL1: view

Protein tissue co-expression partners for UFL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UFL1 Gene

Orthologs for UFL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UFL1 35
  • 91.2 (n)
  • 92.93 (a)
UFL1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UFL1 35
  • 92.25 (n)
  • 93.88 (a)
UFL1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ufl1 35
  • 87.01 (n)
  • 90.67 (a)
Ufl1 16
Ufl1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UFL1 35
  • 99.75 (n)
  • 99.62 (a)
UFL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ufl1 35
  • 87.1 (n)
  • 90.79 (a)
oppossum
(Monodelphis domestica)
Mammalia UFL1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves UFL1 35
  • 75.76 (n)
  • 75.76 (a)
UFL1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UFL1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ufl1 35
  • 69.14 (n)
  • 68.51 (a)
zebrafish
(Danio rerio)
Actinopterygii ufl1 35
  • 60.94 (n)
  • 63.21 (a)
zgc63562 35
ufl1 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3579 35
African malaria mosquito
(Anopheles gambiae)
Insecta UFL1_ANOGA 35
  • 45.01 (n)
  • 34.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1104 35
  • 46.61 (n)
  • 36.4 (a)
CG1104 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ufl-1 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G46220 35
  • 43.28 (n)
  • 27.62 (a)
rice
(Oryza sativa)
Liliopsida Os05g0117600 35
  • 43.69 (n)
  • 29.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for UFL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UFL1 Gene

ENSEMBL:
Gene Tree for UFL1 (if available)
TreeFam:
Gene Tree for UFL1 (if available)

Paralogs for UFL1 Gene

No data available for Paralogs for UFL1 Gene

Variants for UFL1 Gene

Sequence variations from dbSNP and Humsavar for UFL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_034037 -
rs1043252 -- 96,554,529(+) CAAAT(G/T)AATTT utr-variant-3-prime
rs1127175 -- 96,551,849(+) GAAGA(C/T)TTTAT reference, synonymous-codon
rs5878434 -- 96,522,978(+) TTTTT(-/T)AACTT intron-variant
rs5878435 -- 96,533,799(+) AAGCA(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UFL1 Gene

Variant ID Type Subtype PubMed ID
nsv886424 CNV Loss 21882294

Variation tolerance for UFL1 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UFL1 Gene

HapMap Linkage Disequilibrium report
UFL1
Human Gene Mutation Database (HGMD)
UFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UFL1 Gene

Disorders for UFL1 Gene

Relevant External Links for UFL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UFL1

No disorders were found for UFL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UFL1 Gene

Publications for UFL1 Gene

  1. A novel type of E3 ligase for the Ufm1 conjugation system. (PMID: 20018847) Tatsumi K. … Komatsu M. (J. Biol. Chem. 2010) 2 3 4 67
  2. A novel LZAP-binding protein, NLBP, inhibits cell invasion. (PMID: 20164180) Kwon J. … Kim H. (J. Biol. Chem. 2010) 2 3
  3. A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. (PMID: 20228063) Wu J. … Li H. (J. Biol. Chem. 2010) 2 3
  4. Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. (PMID: 20531390) Shiwaku H. … Okazawa H. (EMBO J. 2010) 2 3
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3

Products for UFL1 Gene

Sources for UFL1 Gene

Content