UFD1L Gene
protein-coding GIFtS: 63
GCID: GC22M019437
|
|
ubiquitin fusion degradation 1 like (yeast)(Previous name: ubiquitin fusion degradation 1-like )
| |
Aliases
for UFD1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Fusion Degradation 1 Like (Yeast)1 2 | | UFD11 2 | | UB Fusion Protein 12 3 | | Ubiquitin Fusion Degradation 1-Like1 | | Ubiquitin Fusion Degradation Protein 1 Homolog2 |
Export aliases for UFD1L gene to outside databasesPrevious GC identifers: GC22M016377 GC22M017812 GC22M003058 |
Summaries
for UFD1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UFD1L:
The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 andvalosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition,this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope aftermitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacialdefects. Alternative splicing results in multiple transcript variants encoding different isoforms. A relatedpseudogene has been identified on chromosome 18. (provided by RefSeq, Jun 2009)
UniProtKB/Swiss-Prot: UFD1_HUMAN, Q92890Function: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins.The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export ofmisfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCPcomplex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclearenvelope. It may be involved in the development of some ectoderm-derived structures
Gene Wiki entry for UFD1L
|
Genomic Views
for UFD1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011519.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UFD1L gene promoter:
Pax-2 NF-YC Pax-2a CBF-C CBF-A CBF-B CP1C CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for UFD1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UFD1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.2UFD1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M019437: view genomic region
(about GC identifiers)
Start:
|
19,437,464 bp from pter |
End:
|
19,466,738 bp from pter |
Size:
|
29,275 bases |
Orientation:
|
minus strand |
|
Proteins
for UFD1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UFD1_HUMAN, Q92890 (See
protein sequence)Recommended Name: Ubiquitin fusion degradation protein 1 homolog Size: 307 amino acids; 34500 Da
Subunit: Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13
Subcellular location: Nucleus (By similarity). Cytoplasm, cytosol (By similarity)
1 PDB 3D structure from  and Proteopedia  for UFD1L:2YUJ (3D)
Secondary accessions: A8MW31 Q9Y5N0Alternative splicing: 3 isoforms: Q92890-2 Q92890-1 Q92890-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UFD1L: NX_Q92890
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92890
UFD1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001030324.2 NP_005650.2
ENSEMBL proteins: ENSP00000263202 ENSP00000382439 ENSP00000402136 ENSP00000406680 ENSP00000418390 ENSP00000418295 ENSP00000354079
Human Recombinant Protein Products for UFD1L:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UFD1L for ontologies About GeneDecksing
UFD1L Antibody Products:
Assay Products for UFD1L: |
Protein
Domains /
Families
for UFD1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UFD1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q92890ProtoNet protein and cluster: Q92890 1 Blocks protein family: IPB004854 Ubiquitin fusion degradation protein UFD1
UniProtKB/Swiss-Prot: UFD1_HUMAN, Q92890Similarity: Belongs to the UFD1 family |
Function
for UFD1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: UFD1_HUMAN, Q92890Function: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins.The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export ofmisfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCPcomplex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclearenvelope. It may be involved in the development of some ectoderm-derived structures Genatlas biochemistry entry for UFD1L:yeast ubiquitin fusion-degradation protein-1 homolog,potential housekeeping gene,ubiquitously expressed,with multipleprotein isoforms,deleted but not mutated in DiGeorge syndrome (CATCH22),activated by HAND2 and involved in controllingneural crest development
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UFD1L for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for UFD1L:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ufd1l):
UFD1L for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Ufd1ltm1Bld for UFD1L
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UFD1L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UFD1L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): UFD1L (NM_005659) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UFD1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFD1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFD1L |
|
Pathways & Interactions
for UFD1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of degradation of wt-CFTR | | | 2 | Protein processing in endoplasmic reticulum | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  GeneGo (Thomson Reuters) Pathways for UFD1L
1 
Kegg Pathway (Kegg details for UFD1L):
UniProtKB/Swiss-Prot: UFD1_HUMAN, Q92890Pathway: Protein degradation; proteasomal ubiquitin-dependent pathway
UFD1L for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UFD1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/74 Interacting proteins for UFD1L (Q928902, 3 ENSP000002632024) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001501 | skeletal system development |
TAS | 10024240 | | GO:0006511 | ubiquitin-dependent protein catabolic process |
TAS | 9063746 | | GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process |
IEA | -- |
UFD1L for ontologies About GeneDecksing
|
Drugs & Compounds
for UFD1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UFD1L
Search CenterWatch for drugs/clinical trials and news about UFD1L / UFD1
|
Transcripts
for UFD1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UFD1L gene (2 alternative transcripts): NM_001035247.2 NM_005659.6 Unigene Cluster for UFD1L: Ubiquitin fusion degradation 1 like (yeast) Hs.474213 [show with all ESTs]Unigene Representative Sequence: BF68369811 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263202(uc002zpm.2 uc002zpo.2 uc010grq.2) ENST00000459854(uc011agy.1 uc002zpp.2)
ENST00000399523 ENST00000466373 ENST00000447868 ENST00000421968 ENST00000484101
ENST00000489406 ENST00000494054 ENST00000474226 ENST00000360834
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UFD1L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UFD1L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UFD1L (NM_005659) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UFD1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFD1L |
Additional cDNA sequence: AF141201.1 AJ239058.1 AK225877.1 AK304734.1 AK308786.1 AK310950.1 AK315998.1 AY101594.1 BC001049.2 BC005087.1 CR456607.1 21 DOTS entries: DT.97861046 DT.454946 DT.100815868 DT.100045664 DT.75173115 DT.100815869 DT.75200335 DT.91891011 DT.100815872 DT.101961634 DT.97861048 DT.100032361 DT.100719583 DT.101982921 DT.120652521 DT.120652530 DT.75171765 DT.404420 DT.75110689 DT.91695531 DT.97786207 24/385 AceView cDNA sequences (see all 385): BQ065701 BU740740 BM781891 BI905890 CR607101 BM053156 AA236368 BM817798 BM453050 BQ710818 CA772012 BG026403 BM552525 CB154783 BC005087 AA565750 AK128120 CB156445 BC001049 CA843324 AW169417 AF141201 CA424422 CF126918
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for UFD1L About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 |
|---|
|
| SP1: | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UFD1L
|
Expression
for UFD1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UFD1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAGTCGAC
About this image
See UFD1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UFD1L
SOURCE GeneReport for Unigene cluster: Hs.474213
UniProtKB/Swiss-Prot: UFD1_HUMAN, Q92890Tissue specificity: Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney
SABiosciences Expression via Pathway-Focused PCR Array including UFD1L:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UFD1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UFD1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UFD1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UFD1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFD1L |
Orthologs
for UFD1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UFD1L gene from 10/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ufd1l1 , 5 |
ubiquitin fusion degradation 1 like1, 5 |
89.25(n)1
98.7(a)1 |
|
16 (11.65 cM)5
222301 NM_011672.41 NP_035802.31
188117795 |
chicken
(Gallus gallus) |
Aves |
UFD1L1 |
ubiquitin fusion degradation 1 like (yeast) |
82.19(n)
94.79(a) |
|
374186 NM_204301.1 NP_989632.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UFD1L6 |
-- |
93(a) |
1 ↔ 1 |
GL343282.1(1475761-1490100) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC061930.12 |
-- |
77.93(n) |
|
BC061930.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CK398832.12 |
-- |
82.02(n) |
|
325109 CK398832.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ufd1-like1 , 3 |
ubiquitin-dependent protein catabolism3
Ubiquitin fusion-degradation 1-like1 |
50(a)3
61.55(n)1
61.43(a)1 |
|
68A73
392541 NM_079299.31 NP_524023.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ufd-11 |
Protein UFD-1 |
52.4(n)
46.21(a) |
|
3565860 NM_069947.2 NP_502348.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UFD1(YGR048W)4
UFD11 |
Protein that interacts with Cdc48p and Npl4p, involved more4
Ufd1p1 |
49.76(n)1
43.26(a)1 |
|
7(589826-590911)4
8529391, 4 NP_011562.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G389301 |
ubiquitin fusion degradation UFD1 family protein |
54.36(n)
49.46(a) |
|
830048 NM_202980.2 NP_974709.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.180102 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
72.12(n) |
|
AK121784.1 |
ENSEMBL Gene Tree for UFD1L (if available)
TreeFam Gene Tree for UFD1L (if available) |
Paralogs
for UFD1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UFD1L gene
UFD1L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UFD1L
PGOHUM00000234905
|
Genomic Variants
for UFD1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UFD1L (19437464 - 19466738 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for UFD1L
2 CNVs: 8901 31071
Human Gene Mutation Database (HGMD): UFD1L
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UFD1L |
|
Disorders
/ Diseases
for UFD1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UFD1L for disorders About GeneDecksing
OMIM gene information: 601754
OMIM disorders: --
12  diseases for UFD1L: About MalaCardsconotruncal anomaly face syndrome faces syndrome velocardiofacial syndrome digeorge syndrome
tetralogy of fallot intrahepatic cholangiocarcinoma ependymoma cholangiocarcinoma
cholera cholesterol schizophrenia malaria
2 diseases from the University of Copenhagen DISEASES database for UFD1L:Velocardiofacial syndrome DiGeorge syndrome 3 Novoseek disease relationships for UFD1L gene About this table
Genetic Association Database (GAD): UFD1L
Human Genome Epidemiology (HuGE) Navigator: UFD1L (3 documents)
Export disorders for UFD1L gene to outside databases
|
Publications
for UFD1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UFD1L gene, integrated from 9 sources (see all 77):
(articles sorted by number of sources associating them with UFD1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome. (PubMed id 9063746)1, 2, 3, 9 Pizzuti A....Dallapiccola B. (1997)
- Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). (PubMed id 11574150)1, 2, 9 Botta A....Novelli G. (2001)
- Ubiquitin-recognition protein Ufd1 couples the endopl asmic reticulum (ER) stress response to cell cycle control. (PubMed id 21571647)1, 2 Chen M....Ronai Z.A. (2011)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies. (PubMed id 12910480)1, 9 Amati F....Novelli G. (2003)
- Functional characterization of the 5' flanking region of human ubiquitin fusion degradation 1 like gene (UFD1L). (PubMed id 11979512)1, 9 Amati F....Novelli G. (2002)
- Association study of a promoter polymorphism of UFD1L gene with schizophrenia. (PubMed id 11496370)4, 9 De Luca A....Novelli G. (2001)
- Structure and expression of the human ubiquitin fusion-degradation gene (UFD1L). (PubMed id 9540831)1, 9 Novelli G....Dallapiccola B. (1998)
- A family- and population-based study of the UFD1L gene for schizophrenia. (PubMed id 18270977)1, 9 Xie L....Wei J. (2008)
|
External Searches for UFD1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UFD1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UFD1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UFD1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for UFD1L | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for UFD1L gene:
Search GeneIP for patents involving UFD1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UFD1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for UFD1L | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UFD1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UFD1L | | | OriGene Protein Over-expression Lysate for UFD1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UFD1L | | OriGene 3'-UTR Clone for UFD1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UFD1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UFD1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UFD1L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UFD1L | | OriGene Custom Protein Services for UFD1L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UFD1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UFD1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UFD1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UFD1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UFD1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UFD1L |
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| | | | Search Tocris compounds for UFD1L |
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 | | | UFD1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFD1L |
|  |  |  |  | | | | ThermoFisher Antibody for UFD1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFD1L |
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