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Aliases for UFC1 Gene

Aliases for UFC1 Gene

  • Ubiquitin-Fold Modifier Conjugating Enzyme 1 2 3 5
  • Ufm1-Conjugating Enzyme 1 3 4
  • HSPC155 3

External Ids for UFC1 Gene

Previous GeneCards Identifiers for UFC1 Gene

  • GC01P157937
  • GC01P159390
  • GC01P161122
  • GC01P132480

Summaries for UFC1 Gene

Entrez Gene Summary for UFC1 Gene

  • UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UFC1 Gene

UFC1 (Ubiquitin-Fold Modifier Conjugating Enzyme 1) is a Protein Coding gene. GO annotations related to this gene include UFM1 transferase activity.

UniProtKB/Swiss-Prot for UFC1 Gene

  • E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFC1 Gene

Genomics for UFC1 Gene

Regulatory Elements for UFC1 Gene

Promoters for UFC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UFC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UFC1 Gene

Chromosome:
1
Start:
161,152,776 bp from pter
End:
161,158,856 bp from pter
Size:
6,081 bases
Orientation:
Plus strand

Genomic View for UFC1 Gene

Genes around UFC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UFC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFC1 Gene

Proteins for UFC1 Gene

  • Protein details for UFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C8-UFC1_HUMAN
    Recommended name:
    Ubiquitin-fold modifier-conjugating enzyme 1
    Protein Accession:
    Q9Y3C8
    Secondary Accessions:
    • A8K9R1
    • D3DVF9
    • Q549X0
    • Q5VTX1
    • Q9BS96
    • Q9P009

    Protein attributes for UFC1 Gene

    Size:
    167 amino acids
    Molecular mass:
    19458 Da
    Quaternary structure:
    • Interacts with UBA5 (PubMed:17825256). Interacts with UFL1 (PubMed:20018847). Interacts with KIRREL3 (PubMed:25902260).

    Three dimensional structures from OCA and Proteopedia for UFC1 Gene

neXtProt entry for UFC1 Gene

Proteomics data for UFC1 Gene at MOPED

Post-translational modifications for UFC1 Gene

  • Ubiquitination at Lys 33 and Lys 122
  • Modification sites at PhosphoSitePlus

Other Protein References for UFC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UFC1

No data available for DME Specific Peptides for UFC1 Gene

Domains & Families for UFC1 Gene

Protein Domains for UFC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UFC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3C8

UniProtKB/Swiss-Prot:

UFC1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
genes like me logo Genes that share domains with UFC1: view

No data available for Gene Families for UFC1 Gene

Function for UFC1 Gene

Molecular function for UFC1 Gene

UniProtKB/Swiss-Prot Function:
E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.

Gene Ontology (GO) - Molecular Function for UFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071568 UFM1 transferase activity IDA 15071506
genes like me logo Genes that share ontologies with UFC1: view
genes like me logo Genes that share phenotypes with UFC1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UFC1 Gene

Localization for UFC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UFC1 Gene COMPARTMENTS Subcellular localization image for UFC1 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 2
endoplasmic reticulum 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UFC1 Gene

Pathways & Interactions for UFC1 Gene

SuperPathways for UFC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IDA 23152784
GO:0071569 protein ufmylation IMP 23152784
genes like me logo Genes that share ontologies with UFC1: view

No data available for Pathways by source and SIGNOR curated interactions for UFC1 Gene

Drugs & Compounds for UFC1 Gene

No Compound Related Data Available

Transcripts for UFC1 Gene

Unigene Clusters for UFC1 Gene

Ubiquitin-fold modifier conjugating enzyme 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UFC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6:
SP7: -

Relevant External Links for UFC1 Gene

GeneLoc Exon Structure for
UFC1
ECgene alternative splicing isoforms for
UFC1

Expression for UFC1 Gene

mRNA expression in normal human tissues for UFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UFC1 Gene

This gene is overexpressed in Skin (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UFC1 Gene



SOURCE GeneReport for Unigene cluster for UFC1 Gene Hs.301412

genes like me logo Genes that share expression patterns with UFC1: view

Protein tissue co-expression partners for UFC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UFC1 Gene

Orthologs for UFC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UFC1 35
  • 92.42 (n)
  • 99.4 (a)
UFC1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UFC1 35
  • 92.22 (n)
  • 98.8 (a)
UFC1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ufc1 35
  • 91.42 (n)
  • 97.01 (a)
Ufc1 16
Ufc1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UFC1 35
  • 99.2 (n)
  • 99.4 (a)
UFC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ufc1 35
  • 92.22 (n)
  • 98.2 (a)
oppossum
(Monodelphis domestica)
Mammalia UFC1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UFC1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UFC1 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11450 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17015 35
ufc1 35
  • 74.8 (n)
  • 87.8 (a)
ufc1 36
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10558 35
African malaria mosquito
(Anopheles gambiae)
Insecta UFC1_ANOGA 35
  • 70.66 (n)
  • 79.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8386 35
  • 71.75 (n)
  • 79.27 (a)
CG8386 36
  • 79 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C40H1.6 35
  • 68.13 (n)
  • 71.87 (a)
ufc-1 36
  • 71 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G27530 35
  • 62.32 (n)
  • 67.08 (a)
soybean
(Glycine max)
eudicotyledons Gma.17782 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7569 35
rice
(Oryza sativa)
Liliopsida Os10g0205200 35
  • 61.08 (n)
  • 63.35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4548 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6399 36
  • 78 (a)
OneToOne
Species with no ortholog for UFC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UFC1 Gene

ENSEMBL:
Gene Tree for UFC1 (if available)
TreeFam:
Gene Tree for UFC1 (if available)

Paralogs for UFC1 Gene

Pseudogenes.org Pseudogenes for UFC1 Gene

genes like me logo Genes that share paralogs with UFC1: view

No data available for Paralogs for UFC1 Gene

Variants for UFC1 Gene

Sequence variations from dbSNP and Humsavar for UFC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_028312 -
rs4656988 -- 161,153,113(+) AGTTT(A/G)TTTAT upstream-variant-2KB
rs11588225 -- 161,151,881(+) agccg(A/G)gcgtg upstream-variant-2KB
rs12031437 -- 161,157,185(+) GTGGC(C/G)TAAGC intron-variant
rs12145282 -- 161,156,344(+) GCTAA(C/T)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UFC1 Gene

Variant ID Type Subtype PubMed ID
esv2657506 CNV Deletion 23128226

Variation tolerance for UFC1 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UFC1 Gene

HapMap Linkage Disequilibrium report
UFC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UFC1 Gene

Disorders for UFC1 Gene

Relevant External Links for UFC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UFC1

No disorders were found for UFC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UFC1 Gene

Publications for UFC1 Gene

  1. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PMID: 15071506) Komatsu M. … Tanaka K. (EMBO J. 2004) 2 3 4 67
  2. NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway. (PMID: 19101823) Liu G. … Szyperski T. (J. Struct. Funct. Genomics 2009) 3 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  4. Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections. (PMID: 25213431) Tellermann A. … Baerlecken N.T. (HIV Med. 2015) 3
  5. The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of I^-catenin in HCC cells. (PMID: 25449213) Cao C. … Liu L. (Gastroenterology 2015) 3

Products for UFC1 Gene

Sources for UFC1 Gene

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