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Aliases for UFC1 Gene

Aliases for UFC1 Gene

  • Ubiquitin-Fold Modifier Conjugating Enzyme 1 2 3 5
  • Ufm1-Conjugating Enzyme 1 3 4
  • Ubiquitin-Fold Modifier-Conjugating Enzyme 1 3
  • HSPC155 3

External Ids for UFC1 Gene

Previous GeneCards Identifiers for UFC1 Gene

  • GC01P157937
  • GC01P159390
  • GC01P161122
  • GC01P132480

Summaries for UFC1 Gene

Entrez Gene Summary for UFC1 Gene

  • UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UFC1 Gene

UFC1 (Ubiquitin-Fold Modifier Conjugating Enzyme 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include UFM1 transferase activity.

UniProtKB/Swiss-Prot for UFC1 Gene

  • E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.

Additional gene information for UFC1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFC1 Gene

Genomics for UFC1 Gene

GeneHancer (GH) Regulatory Elements for UFC1 Gene

Promoters and enhancers for UFC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I161152 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.4 1382 2.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B UFC1 B4GALT3 ENSG00000224985
GH01I161043 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -105.9 -105887 5.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 GC01P161046 PIR33280 USF1 DEDD TSTD1 LOC100287049 ARHGAP30 LOC105371471 NECTIN4 KLHDC9
GH01I161158 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.4 +7.7 7722 4.9 HDGF SIN3A YY1 POLR2B E2F8 ZNF207 ZNF143 DEK SP3 SP5 ENSG00000224985 USP21 NIT1 TSTD1 UFC1 PPOX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UFC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UFC1 gene promoter:

Genomic Locations for UFC1 Gene

Genomic Locations for UFC1 Gene
6,081 bases
Plus strand

Genomic View for UFC1 Gene

Genes around UFC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UFC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFC1 Gene

Proteins for UFC1 Gene

  • Protein details for UFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-fold modifier-conjugating enzyme 1
    Protein Accession:
    Secondary Accessions:
    • A8K9R1
    • D3DVF9
    • Q549X0
    • Q5VTX1
    • Q9BS96
    • Q9P009

    Protein attributes for UFC1 Gene

    167 amino acids
    Molecular mass:
    19458 Da
    Quaternary structure:
    • Interacts with UBA5 (PubMed:17825256). Interacts with UFL1 (PubMed:20018847). Interacts with KIRREL3 (PubMed:25902260).

    Three dimensional structures from OCA and Proteopedia for UFC1 Gene

neXtProt entry for UFC1 Gene

Post-translational modifications for UFC1 Gene

  • Ubiquitination at isoforms=33 and posLast=122122

Other Protein References for UFC1 Gene

No data available for DME Specific Peptides for UFC1 Gene

Domains & Families for UFC1 Gene

Gene Families for UFC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UFC1 Gene

Suggested Antigen Peptide Sequences for UFC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
  • Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
genes like me logo Genes that share domains with UFC1: view

Function for UFC1 Gene

Molecular function for UFC1 Gene

UniProtKB/Swiss-Prot Function:
E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.

Gene Ontology (GO) - Molecular Function for UFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20018847
GO:0071568 UFM1 transferase activity IDA 15071506
genes like me logo Genes that share ontologies with UFC1: view
genes like me logo Genes that share phenotypes with UFC1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UFC1 Gene

Localization for UFC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UFC1 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with UFC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UFC1 Gene

Pathways & Interactions for UFC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IDA 23152784
GO:0071569 protein ufmylation IMP 23152784
GO:1990592 protein K69-linked ufmylation IDA 25219498
genes like me logo Genes that share ontologies with UFC1: view

No data available for Pathways by source and SIGNOR curated interactions for UFC1 Gene

Drugs & Compounds for UFC1 Gene

No Compound Related Data Available

Transcripts for UFC1 Gene

Unigene Clusters for UFC1 Gene

Ubiquitin-fold modifier conjugating enzyme 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UFC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP7: -

Relevant External Links for UFC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UFC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UFC1 Gene

This gene is overexpressed in Skin (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UFC1 Gene

Protein tissue co-expression partners for UFC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UFC1 Gene:


SOURCE GeneReport for Unigene cluster for UFC1 Gene:


Evidence on tissue expression from TISSUES for UFC1 Gene

  • Blood(4.3)
  • Nervous system(3.1)
  • Lung(2.6)
  • Intestine(2.5)
  • Liver(2)
genes like me logo Genes that share expression patterns with UFC1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UFC1 Gene

Orthologs for UFC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UFC1 33 34
  • 99.2 (n)
(Monodelphis domestica)
Mammalia UFC1 34
  • 94 (a)
(Bos Taurus)
Mammalia UFC1 33 34
  • 92.42 (n)
(Canis familiaris)
Mammalia UFC1 33 34
  • 92.22 (n)
(Rattus norvegicus)
Mammalia Ufc1 33
  • 92.22 (n)
(Mus musculus)
Mammalia Ufc1 33 16 34
  • 91.42 (n)
(Ornithorhynchus anatinus)
Mammalia UFC1 34
  • 77 (a)
(Anolis carolinensis)
Reptilia UFC1 34
  • 87 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11450 33
(Danio rerio)
Actinopterygii ufc1 33 34
  • 74.8 (n)
Dr.17015 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10558 33
fruit fly
(Drosophila melanogaster)
Insecta CG8386 33 34
  • 71.75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta UFC1_ANOGA 33
  • 70.66 (n)
(Caenorhabditis elegans)
Secernentea ufc-1 34
  • 71 (a)
C40H1.6 33
  • 68.13 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G27530 33
  • 62.32 (n)
(Glycine max)
eudicotyledons Gma.17782 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7569 33
(Oryza sativa)
Liliopsida Os10g0205200 33
  • 61.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6399 34
  • 78 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4548 33
Species where no ortholog for UFC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UFC1 Gene

Gene Tree for UFC1 (if available)
Gene Tree for UFC1 (if available)

Paralogs for UFC1 Gene Pseudogenes for UFC1 Gene

genes like me logo Genes that share paralogs with UFC1: view

No data available for Paralogs for UFC1 Gene

Variants for UFC1 Gene

Sequence variations from dbSNP and Humsavar for UFC1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000052246 -- 161,144,857(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000153866 -- 161,132,967(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000171272 -- 161,140,569(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000326172 -- 161,148,490(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000351823 -- 161,140,167(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UFC1 Gene

Variant ID Type Subtype PubMed ID
esv2657506 CNV deletion 23128226

Variation tolerance for UFC1 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UFC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UFC1 Gene

Disorders for UFC1 Gene

Additional Disease Information for UFC1

No disorders were found for UFC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UFC1 Gene

Publications for UFC1 Gene

  1. NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway. (PMID: 19101823) Liu G … Szyperski T (Journal of structural and functional genomics 2009) 3 4 22 58
  2. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PMID: 15071506) Komatsu M … Tanaka K (The EMBO journal 2004) 2 3 4 58
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  4. A novel type of E3 ligase for the Ufm1 conjugation system. (PMID: 20018847) Tatsumi K … Komatsu M (The Journal of biological chemistry 2010) 3 4 58
  5. Crystal structure of Ufc1, the Ufm1-conjugating enzyme. (PMID: 17825256) Mizushima T … Yamane T (Biochemical and biophysical research communications 2007) 4 22 58

Products for UFC1 Gene

Sources for UFC1 Gene

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