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Aliases for UFC1 Gene

Aliases for UFC1 Gene

  • Ubiquitin-Fold Modifier Conjugating Enzyme 1 2 3
  • Ufm1-Conjugating Enzyme 1 3 4
  • Ubiquitin-Fold Modifier-Conjugating Enzyme 1 3
  • HSPC155 3

External Ids for UFC1 Gene

Summaries for UFC1 Gene

Entrez Gene Summary for UFC1 Gene

  • UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UFC1 Gene

UFC1 (Ubiquitin-Fold Modifier Conjugating Enzyme 1) is a Protein Coding gene. GO annotations related to this gene include UFM1 transferase activity.

UniProtKB/Swiss-Prot for UFC1 Gene

  • E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UFC1 Gene

Genomics for UFC1 Gene

Genomic Location for UFC1 Gene

Start:
161,152,776 bp from pter
End:
161,158,856 bp from pter
Size:
6,081 bases
Orientation:
Plus strand

Genomic View for UFC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UFC1 Gene

Regulatory Elements for UFC1 Gene

Proteins for UFC1 Gene

  • Protein details for UFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C8-UFC1_HUMAN
    Recommended name:
    Ubiquitin-fold modifier-conjugating enzyme 1
    Protein Accession:
    Q9Y3C8
    Secondary Accessions:
    • A8K9R1
    • D3DVF9
    • Q549X0
    • Q5VTX1
    • Q9BS96
    • Q9P009

    Protein attributes for UFC1 Gene

    Size:
    167 amino acids
    Molecular mass:
    19458 Da
    Quaternary structure:
    • Interacts with UBA5. Interacts with UFL1.

    Three dimensional structures from OCA and Proteopedia for UFC1 Gene

neXtProt entry for UFC1 Gene

Proteomics data for UFC1 Gene at MOPED

Post-translational modifications for UFC1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys33 and Lys122

Other Protein References for UFC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UFC1 Gene

Domains for UFC1 Gene

Protein Domains for UFC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

UFC1_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.:
    • Q9Y3C8
genes like me logo Genes that share domains with UFC1: view

No data available for Gene Families for UFC1 Gene

Function for UFC1 Gene

Molecular function for UFC1 Gene

UniProtKB/Swiss-Prot Function: E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.

Gene Ontology (GO) - Molecular Function for UFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20018847
GO:0071568 UFM1 transferase activity IDA 15071506
genes like me logo Genes that share ontologies with UFC1: view

Phenotypes for UFC1 Gene

genes like me logo Genes that share phenotypes with UFC1: view

miRNA for UFC1 Gene

miRTarBase miRNAs that target UFC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UFC1 Gene

Localization for UFC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UFC1 Gene COMPARTMENTS Subcellular localization image for UFC1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for UFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UFC1: view

Pathways for UFC1 Gene

SuperPathways for UFC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IDA 23152784
GO:0071569 protein ufmylation IMP 23152784
GO:1990564 protein polyufmylation IDA 25219498
genes like me logo Genes that share ontologies with UFC1: view

No data available for Pathways by source for UFC1 Gene

Transcripts for UFC1 Gene

Unigene Clusters for UFC1 Gene

Ubiquitin-fold modifier conjugating enzyme 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UFC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6:
SP7: -

Relevant External Links for UFC1 Gene

GeneLoc Exon Structure for
UFC1
ECgene alternative splicing isoforms for
UFC1

Expression for UFC1 Gene

mRNA expression in normal human tissues for UFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UFC1 Gene

SOURCE GeneReport for Unigene cluster for UFC1 Gene Hs.301412

genes like me logo Genes that share expressions with UFC1: view

Orthologs for UFC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UFC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UFC1 36
  • 99.2 (n)
  • 99.4 (a)
UFC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UFC1 36
  • 92.42 (n)
  • 99.4 (a)
UFC1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UFC1 36
  • 92.22 (n)
  • 98.8 (a)
UFC1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ufc1 36
  • 91.42 (n)
  • 97.01 (a)
Ufc1 16
Ufc1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UFC1 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UFC1 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ufc1 36
  • 92.22 (n)
  • 98.2 (a)
lizard
(Anolis carolinensis)
Reptilia UFC1 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11450 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10558 36
zebrafish
(Danio rerio)
Actinopterygii Dr.17015 36
ufc1 36
  • 74.8 (n)
  • 87.8 (a)
ufc1 37
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta UFC1_ANOGA 36
  • 70.66 (n)
  • 79.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8386 36
  • 71.75 (n)
  • 79.27 (a)
CG8386 37
  • 79 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C40H1.6 36
  • 68.13 (n)
  • 71.87 (a)
ufc-1 37
  • 71 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7569 36
soybean
(Glycine max)
eudicotyledons Gma.17782 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G27530 36
  • 62.32 (n)
  • 67.08 (a)
rice
(Oryza sativa)
Liliopsida Os10g0205200 36
  • 61.08 (n)
  • 63.35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4548 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6399 37
  • 78 (a)
OneToOne
Species with no ortholog for UFC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UFC1 Gene

ENSEMBL:
Gene Tree for UFC1 (if available)
TreeFam:
Gene Tree for UFC1 (if available)

Paralogs for UFC1 Gene

Pseudogenes.org Pseudogenes for UFC1 Gene

genes like me logo Genes that share paralogs with UFC1: view

No data available for Paralogs for UFC1 Gene

Variants for UFC1 Gene

Sequence variations from dbSNP and Humsavar for UFC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4656988 -- 161,153,113(+) AGTTT(A/G)TTTAT upstream-variant-2KB
rs11588225 -- 161,151,881(+) agccg(A/G)gcgtg upstream-variant-2KB
rs12031437 -- 161,157,185(+) GTGGC(C/G)TAAGC intron-variant
rs12065930 -- 161,153,366(+) ACATC(A/C)TTCTA upstream-variant-2KB
rs12145282 -- 161,156,344(+) GCTAA(C/T)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UFC1 Gene

Variant ID Type Subtype PubMed ID
esv2657506 CNV Deletion 23128226

Relevant External Links for UFC1 Gene

HapMap Linkage Disequilibrium report
UFC1

Disorders for UFC1 Gene

No disorders were found for UFC1 Gene.

No data available for UniProtKB/Swiss-Prot for UFC1 Gene

Publications for UFC1 Gene

  1. NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway. (PMID: 19101823) Liu G. … Szyperski T. (J. Struct. Funct. Genomics 2009) 3 4 23
  2. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PMID: 15071506) Komatsu M. … Tanaka K. (EMBO J. 2004) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Crystal structure of Ufc1, the Ufm1-conjugating enzyme. (PMID: 17825256) Mizushima T. … Yamane T. (Biochem. Biophys. Res. Commun. 2007) 4 23

Products for UFC1 Gene

Sources for UFC1 Gene

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