Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UFC1 Gene

protein-coding   GIFtS: 53
GCID: GC01P161122

Ubiquitin-Fold Modifier Conjugating Enzyme 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin-Fold Modifier Conjugating Enzyme 11 2
Ufm1-Conjugating Enzyme 12 3
HSPC1552
Ubiquitin-Fold Modifier-Conjugating Enzyme 12

External Ids:    HGNC: 269411   Entrez Gene: 515062   Ensembl: ENSG000001432227   OMIM: 6105545   UniProtKB: Q9Y3C83   

Export aliases for UFC1 gene to outside databases

Previous GC identifers: GC01P157937 GC01P159390 GC01P132480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UFC1 Gene:
UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004
(PubMed 15071506)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UFC1 Gene:
UFC1 (ubiquitin-fold modifier conjugating enzyme 1) is a protein-coding gene. GO annotations related to this gene include UFM1 conjugating enzyme activity.

UniProtKB/Swiss-Prot: UFC1_HUMAN, Q9Y3C8
Function: E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UFC1 gene promoter:
         p53   ATF-2   E2F-2   NF-kappaB   CREB   E2F-1   deltaCREB   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UFC1 promoter sequence
   Search Chromatin IP Primers for UFC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UFC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

UFC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UFC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161122:  view genomic region     (about GC identifiers)

Start:
161,122,566 bp from pter      End:
161,128,646 bp from pter
Size:
6,081 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UFC1_HUMAN, Q9Y3C8 (See protein sequence)
Recommended Name: Ubiquitin-fold modifier-conjugating enzyme 1  
Size: 167 amino acids; 19458 Da
Subunit: Interacts with UBA5. Interacts with UFL1
4 PDB 3D structures from and Proteopedia for UFC1:
2K07 (3D)        2Z6O (3D)        2Z6P (3D)        3EVX (3D)    
Secondary accessions: A8K9R1 D3DVF9 Q549X0 Q5VTX1 Q9BS96 Q9P009

Explore the universe of human proteins at neXtProt for UFC1: NX_Q9Y3C8

Explore proteomics data for UFC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys33, Lys122
  • Modification sites at PhosphoSitePlus

  • See UFC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057490.2  
    ENSEMBL proteins: 
     ENSP00000356982  

    UFC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UFC1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UFC1
    OriGene Protein Over-expression Lysate for UFC1
    OriGene MassSpec for UFC1
    OriGene Custom Protein Services for UFC1
    GenScript Custom Purified and Recombinant Proteins Services for UFC1
    Novus Biologicals UFC1 Proteins
    Novus Biologicals UFC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UFC1
    Cloud-Clone Corp. Proteins for UFC1

     
    Search eBioscience for Proteins for UFC1 

     
    antibodies-online proteins for UFC1 (11 products) 

     
    Search antibodies-online for peptides for UFC1

    UFC1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UFC1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UFC1
    Novus Biologicals UFC1 Antibodies
    Abcam antibodies for UFC1
    Cloud-Clone Corp. Antibodies for UFC1
    ThermoFisher Antibodies for UFC1
    antibodies-online antibodies for UFC1 (32 products) 

    UFC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UFC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UFC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UFC1
    Cloud-Clone Corp. CLIAs for UFC1
    Search eBioscience for ELISAs for UFC1 
    antibodies-online kits for UFC1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR014806 Ufc1

    Graphical View of Domain Structure for InterPro Entry Q9Y3C8

    ProtoNet protein and cluster: Q9Y3C8

    UniProtKB/Swiss-Prot: UFC1_HUMAN, Q9Y3C8
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily


    Find genes that share domains with UFC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UFC1_HUMAN, Q9Y3C8
    Function: E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0071568UFM1 conjugating enzyme activity IDA15071506
         
    Find genes that share ontologies with UFC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UFC1:
     Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UFC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UFC1:
    hsa-mir-744-5p (MIRT037383), hsa-mir-16-5p (MIRT031996), hsa-mir-26b-5p (MIRT030112)

    Block miRNA regulation of human, mouse, rat UFC1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate UFC1:
    hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidUFC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UFC1
    Predesigned siRNA for gene silencing in human, mouse, rat UFC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UFC1

    Clone
    Products:
         
    OriGene clones in human, mouse for UFC1 (see all 7)
    OriGene ORF clones in mouse, rat for UFC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): UFC1 (NM_002494)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UFC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UFC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for UFC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with UFC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UFC1
    Interactions:

        Search GeneGlobe Interaction Network for UFC1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for UFC1 (Q9Y3C83 ENSP000003569824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBA5Q9GZZ93, ENSP000003485654I2D: score=8 STRING: ENSP00000348565
    CDK5RAP3Q96JB53, ENSP000003446834I2D: score=2 STRING: ENSP00000344683
    UFM1P619603, ENSP000002398784I2D: score=1 STRING: ENSP00000239878
    GSTCDQ8NEC73I2D: score=3 
    MEF2CQ064133I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034976response to endoplasmic reticulum stress IDA--
    GO:0071569protein ufmylation IMP--

    Find genes that share ontologies with UFC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UFC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UFC1 gene: 
    NM_016406.3  

    Unigene Cluster for UFC1:

    Ubiquitin-fold modifier conjugating enzyme 1
    Hs.301412  [show with all ESTs]
    Unigene Representative Sequence: BC005187
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467540 ENST00000368003(uc001fyd.4) ENST00000483191 ENST00000482672
    ENST00000473766 ENST00000463735
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UFC1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate UFC1:
    hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidUFC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UFC1
    Predesigned siRNA for gene silencing in human, mouse, rat UFC1
    Clone
    Products:
         
    OriGene clones in human, mouse for UFC1 (see all 7)
    OriGene ORF clones in mouse, rat for UFC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): UFC1 (NM_002494)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UFC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFC1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UFC1
    OriGene qSTAR qPCR primer pairs in human, mouse for UFC1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat UFC1
      QuantiTect SYBR Green Assays in human, mouse, rat UFC1
      QuantiFast Probe-based Assays in human, mouse, rat UFC1

    Additional mRNA sequence: 

    AB154405.1 AF151884.1 AF161504.1 AK292776.1 AK311562.1 BC005187.1 

    19 DOTS entries:

    DT.92409335  DT.100832066  DT.120603  DT.95350417  DT.95350460  DT.121398577  DT.100038275  DT.100038276 
    DT.427344  DT.100832070  DT.121398547  DT.100666364  DT.102837474  DT.91941342  DT.95076025  DT.95350458 
    DT.97802012  DT.100832068  DT.120696246 

    Selected AceView cDNA sequences (see all 459):

    BM711136 AA461150 BQ632531 BM983191 CA417937 BQ924453 AA973740 AI225090 
    AA025393 CB133757 CA865550 BM852677 CB159489 AA125939 BM670640 CA436914 
    AA047794 AW518561 T35178 BF222315 BU752352 BU527294 R32185 AA054937 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UFC1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                                                                    -     -           -                           
    SP2:                                                                    -     -           -     -                     
    SP3:                                                        -           -     -           -     -                     
    SP4:              -     -                                                                                             
    SP5:                                                                    -     -                                       


    ECgene alternative splicing isoforms for UFC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UFC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGATTCTGGA
    UFC1 Expression
    About this image


    UFC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
    UFC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UFC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301412
        Custom PCR Arrays for UFC1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UFC1
    OriGene qSTAR qPCR primer pairs in human, mouse for UFC1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat UFC1
    QuantiTect SYBR Green Assays in human, mouse, rat UFC1
    QuantiFast Probe-based Assays in human, mouse, rat UFC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UFC1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ufc11 , 5 ubiquitin-fold modifier conjugating enzyme 11, 5 91.42(n)1
    97.01(a)1
      1 (79.31 cM)5
    661551  NM_025388.21  NP_079664.11 
     1712885635 
    lizard
    (Anolis carolinensis)
    Reptilia UFC16
    ubiquitin-fold modifier conjugating enzyme 1
    87(a)
    1 ↔ 1
    GL343781.1(17430-22011)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114502 Xenopus laevis transcribed sequence with moderate similarity more 80.49(n)    BJ038717.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.170152 Transcribed sequence with moderate similarity to protein more 76.6(n)    BG892124.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83861 CG8386 71.75(n)
    79.27(a)
      36762  NM_137230.2  NP_611074.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C40H1.61 C40H1.6 68.13(n)
    71.87(a)
      176313  NM_066654.4  NP_499055.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G275301 AT1G27530 62.32(n)
    67.08(a)
      839644  NM_102517.4  NP_564289.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g02052001 Os10g0205200 61.08(n)
    63.35(a)
      4348269  NM_001070844.1  NP_001064309.1 


    ENSEMBL Gene Tree for UFC1 (if available)
    TreeFam Gene Tree for UFC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UFC1 gene

    Find genes that share paralogs with UFC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UFC1
    PGOHUM00000233450


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UFC1 (see all 102)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436672281,2
    --161121550(+) GGCTCA/GCGCCT 1 -- us2k10--------
    rs1836212091,2
    --161121595(+) GATCAA/CCTGAG 1 -- us2k10--------
    rs1512787311,2
    --161121659(+) AAGTAC/GAAAAT 1 -- us2k10--------
    rs115882251,2
    C,F,H--161121671(+) agccgA/Ggcgtg 1 -- us2k16Minor allele frequency- G:0.32NA WA CSA EA 364
    rs2006072231,2
    C--161121836(-) TTTTTG/TTNNNN 1 -- us2k10--------
    rs1886648741,2
    --161122129(+) CGAACG/TCCTGG 1 -- us2k10--------
    rs1916243191,2
    --161122357(+) GCCTCA/CGCCTC 1 -- us2k10--------
    rs1404388061,2
    C--161122483(+) TGCCTC/TGGCCT 1 -- us2k10--------
    rs1846163081,2
    --161122597(+) GCACCC/TTGGGA 1 -- us2k10--------
    rs1504106751,2
    C--161122748(+) GGCAGA/GAGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UFC1 (161122566 - 161128646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UFC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657506CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UFC1
    DNA2.0 Custom Variant and Variant Library Synthesis for UFC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610554    OMIM disorders: --


    Find genes that share disorders with UFC1           About GenesLikeMe


    Export disorders for UFC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UFC1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with UFC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PubMed id 15071506)1, 2, 3 Komatsu M.... Tanaka K. (EMBO J. 2004)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway. (PubMed id 19101823)1, 2, 9 Liu G.... Szyperski T. (J. Struct. Funct. Genomics 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    6. Crystal structure of Ufc1, the Ufm1-conjugating enzyme. (PubMed id 17825256)2, 9 Mizushima T.... Yamane T. (Biochem. Biophys. Res. Commun. 2007)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51506 HGNC: 26941 AceView: Ufc1 Ensembl:ENSG00000143222 euGenes: HUgn51506
    ECgene: UFC1 H-InvDB: UFC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UFC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UFC1 gene:
    Search GeneIP for patents involving UFC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UFC1
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for UFC1 (Ufc1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UFC1  
     OriGene qPCR primer pairs and template standards for UFC1   OriGene Protein Over-expression Lysate for UFC1  
     OriGene MassSpec for UFC1   OriGene clones in human, mouse for UFC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UFC1   OriGene Purified Protein for UFC1  
     OriGene ORF clones in mouse, rat for UFC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UFC1   OriGene Custom Protein Services for UFC1  

     
     
     Block miRNA regulation of human, mouse, rat UFC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UFC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UFC1 Predesigned siRNA for gene silencing in human, mouse, rat UFC1
     QuantiFast Probe-based Assays in human, mouse, rat UFC1 QuantiTect SYBR Green Assays in human, mouse, rat UFC1
     Custom PCR Arrays for UFC1 Search Chromatin IP Primers for UFC1
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat UFC1 Search GeneGlobe Interaction Network for UFC1
     Regulatory tfbs in UFC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UFC1 GenScript cDNA clones with any tag delivered in your preferred vector for UFC1
     GenScript Custom Assay Services for UFC1 GenScript Custom overexpressing Cell Line Services for UFC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UFC1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UFC1 antibodies
     UFC1 proteins
     UFC1 lysates
     Antibodies for UFC1
     See all of Abcam's Antibodies, Kits and Proteins for UFC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UFC1
     Proteins for UFC1
     Antibodies for UFC1
     ELISAs for UFC1
     CLIAs for UFC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for UFC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UFC1
     SwitchGear 3'UTR luciferase reporter plasmids for UFC1
     SwitchGear Promoter luciferase reporter plasmids for UFC1
     ThermoFisher Antibodies for UFC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UFC1
     Browse compounds at ApexBio
     Search Addgene for plasmids for UFC1
      Search eBioscience for proteins for UFC1
      Search eBioscience for elisas for UFC1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for UFC1
     antibodies-online antibodies for UFC1 (32 products)
     antibodies-online kits for UFC1 (8 products)
      Search antibodies-online for peptides for UFC1
     antibodies-online proteins for UFC1 (11 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UFC1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4