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Aliases for UEVLD Gene

Aliases for UEVLD Gene

  • UEV And Lactate/Malate Dehyrogenase Domains 2 3 5
  • EV And Lactate/Malate Dehydrogenase Domain-Containing Protein 3 4
  • UEV-3 3 4
  • UEV3 3 4
  • Ubiquitin-Conjugating Enzyme E2 Variant 3 3
  • Signaling Molecule ATTP 3
  • ATTP 3

External Ids for UEVLD Gene

Previous GeneCards Identifiers for UEVLD Gene

  • GC11M018510
  • GC11M018239

Summaries for UEVLD Gene

GeneCards Summary for UEVLD Gene

UEVLD (UEV And Lactate/Malate Dehyrogenase Domains) is a Protein Coding gene. Among its related pathways are protein ubiquitylation. GO annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is LDHA.

UniProtKB/Swiss-Prot for UEVLD Gene

  • Possible negative regulator of polyubiquitination.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UEVLD Gene

Genomics for UEVLD Gene

Regulatory Elements for UEVLD Gene

Enhancers for UEVLD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G018633 1.1 ENCODE 5.4 -45.3 -45309 2.3 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 SPTY2D1 LDHC YWHABP2 UEVLD TSG101 ENSG00000279837
GH11G018697 1 ENCODE 4.8 -110.3 -110335 3.9 ATF1 SIN3A BRCA1 GLIS2 ZNF143 KLF13 ZNF263 SP3 SP5 NFYC SPTY2D1 HPS5 GTF2H1 TMEM86A IGSF22 LOC105376579 YWHABP2 UEVLD PIR46171
GH11G018617 0.8 Ensembl ENCODE 5.5 -29.3 -29260 1.7 CBFB SCRT2 FOS ETV6 CREM SPTY2D1 LOC105376579 IGSF22 LDHA UEVLD ENSG00000279837
GH11G018608 0.5 ENCODE 5.5 -19.7 -19702 1.1 NFIC PKNOX1 PBX2 SPTY2D1 LOC105376579 IGSF22 GTF2H1 HPS5 UEVLD ENSG00000279837
GH11G018587 1.1 ENCODE 0.7 -0.5 -536 4.8 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DEK LDHC SPTY2D1 TSG101 SERGEF GC11M018587 UEVLD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UEVLD on UCSC Golden Path with GeneCards custom track

Promoters for UEVLD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000037625 338 2001 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DEK SP3

Genomic Location for UEVLD Gene

Chromosome:
11
Start:
18,529,609 bp from pter
End:
18,588,938 bp from pter
Size:
59,330 bases
Orientation:
Minus strand

Genomic View for UEVLD Gene

Genes around UEVLD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UEVLD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UEVLD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UEVLD Gene

Proteins for UEVLD Gene

  • Protein details for UEVLD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX04-UEVLD_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 variant 3
    Protein Accession:
    Q8IX04
    Secondary Accessions:
    • B2RB69
    • B4DL43
    • F5H6L6
    • H7BYD6
    • Q6P2F0
    • Q96FF5
    • Q9NUX7

    Protein attributes for UEVLD Gene

    Size:
    471 amino acids
    Molecular mass:
    52264 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for UEVLD Gene

    Alternative splice isoforms for UEVLD Gene

neXtProt entry for UEVLD Gene

Post-translational modifications for UEVLD Gene

  • Ubiquitination at Lys45
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UEVLD Gene

Domains & Families for UEVLD Gene

Graphical View of Domain Structure for InterPro Entry

Q8IX04

UniProtKB/Swiss-Prot:

UEVLD_HUMAN :
  • In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
Family:
  • In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
  • In the C-terminal section; belongs to the LDH/MDH superfamily.
genes like me logo Genes that share domains with UEVLD: view

No data available for Gene Families for UEVLD Gene

Function for UEVLD Gene

Molecular function for UEVLD Gene

UniProtKB/Swiss-Prot Function:
Possible negative regulator of polyubiquitination.

Gene Ontology (GO) - Molecular Function for UEVLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with UEVLD: view
genes like me logo Genes that share phenotypes with UEVLD: view

Animal Models for UEVLD Gene

MGI Knock Outs for UEVLD:

Animal Model Products

  • Taconic Biosciences Mouse Models for UEVLD

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UEVLD Gene

Localization for UEVLD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UEVLD gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UEVLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UEVLD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UEVLD Gene

Pathways & Interactions for UEVLD Gene

SuperPathways for UEVLD Gene

SuperPathway Contained pathways
1 protein ubiquitylation
genes like me logo Genes that share pathways with UEVLD: view

Pathways by source for UEVLD Gene

1 BioSystems pathway for UEVLD Gene

Gene Ontology (GO) - Biological Process for UEVLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006464 cellular protein modification process IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0019752 carboxylic acid metabolic process IEA --
genes like me logo Genes that share ontologies with UEVLD: view

No data available for SIGNOR curated interactions for UEVLD Gene

Transcripts for UEVLD Gene

Unigene Clusters for UEVLD Gene

UEV and lactate/malate dehyrogenase domains:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UEVLD Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: -
SP10: -
SP11: - - - - - - - -
SP12: - - -
SP13:

ExUns: 15b ^ 16 ^ 17a · 17b · 17c · 17d
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for UEVLD Gene

GeneLoc Exon Structure for
UEVLD
ECgene alternative splicing isoforms for
UEVLD

Expression for UEVLD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UEVLD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UEVLD Gene

This gene is overexpressed in Urine (24.9) and Cervix (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UEVLD Gene



NURSA nuclear receptor signaling pathways regulating expression of UEVLD Gene:

UEVLD

SOURCE GeneReport for Unigene cluster for UEVLD Gene:

Hs.407991

mRNA Expression by UniProt/SwissProt for UEVLD Gene:

Q8IX04-UEVLD_HUMAN
Tissue specificity: Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for UEVLD Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with UEVLD: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UEVLD Gene

Orthologs for UEVLD Gene

This gene was present in the common ancestor of animals.

Orthologs for UEVLD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UEVLD 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia UEVLD 34 35
  • 91.79 (n)
cow
(Bos Taurus)
Mammalia UEVLD 34 35
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Uevld 34 16 35
  • 85 (n)
rat
(Rattus norvegicus)
Mammalia Uevld 34
  • 82.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia UEVLD 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves UEVLD 34 35
  • 70.37 (n)
lizard
(Anolis carolinensis)
Reptilia UEVLD 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uevld 34
  • 61.29 (n)
Str.204 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12325 34
zebrafish
(Danio rerio)
Actinopterygii uevld 34 35
  • 58.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta ImpL3 35
  • 34 (a)
ManyToMany
CG13334 35
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ldh-1 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 35
  • 33 (a)
OneToMany
Species where no ortholog for UEVLD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UEVLD Gene

ENSEMBL:
Gene Tree for UEVLD (if available)
TreeFam:
Gene Tree for UEVLD (if available)

Paralogs for UEVLD Gene

Paralogs for UEVLD Gene

(6) SIMAP similar genes for UEVLD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UEVLD: view

Variants for UEVLD Gene

Sequence variations from dbSNP and Humsavar for UEVLD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000053602 -- 18,555,093(+) AAGAC(C/T)AACCT intron-variant
rs1000063755 -- 18,556,736(+) ACCTA(A/C)ATAAA intron-variant
rs1000077530 -- 18,536,083(+) GAGCC(A/G)AGATC intron-variant
rs1000109228 -- 18,584,373(+) GCAAG(G/T)CTCTG intron-variant
rs1000117978 -- 18,549,784(+) CTCTC(G/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UEVLD Gene

Variant ID Type Subtype PubMed ID
esv2660842 CNV deletion 23128226
esv2761651 CNV loss 21179565
esv3625503 CNV loss 21293372
esv3625504 CNV loss 21293372
esv3625506 CNV loss 21293372
nsv553633 CNV gain 21841781

Variation tolerance for UEVLD Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UEVLD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UEVLD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UEVLD Gene

Disorders for UEVLD Gene

Relevant External Links for UEVLD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UEVLD

No disorders were found for UEVLD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UEVLD Gene

Publications for UEVLD Gene

  1. Identification and characterization of UEV3, a human cDNA with similarities to inactive E2 ubiquitin-conjugating enzymes. (PMID: 12427560) Kloor M. … Ridder R. (Biochim. Biophys. Acta 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for UEVLD Gene

Sources for UEVLD Gene

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