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UEVLD Gene

protein-coding   GIFtS: 50
GCID: GC11M018554

UEV And Lactate/Malate Dehyrogenase Domains

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UEV And Lactate/Malate Dehyrogenase Domains1 2     ATTP2 5
UEV32 3 5     Signaling Molecule ATTP2
UEV-32 3     Ubiquitin-Conjugating Enzyme E2 Variant 32
EV And Lactate/Malate Dehydrogenase Domain-Containing Protein2 3     

External Ids:    HGNC: 308661   Entrez Gene: 552932   Ensembl: ENSG000001511167   OMIM: 6109855   UniProtKB: Q8IX043   

Export aliases for UEVLD gene to outside databases

Previous GC identifers: GC11M018510 GC11M018239


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UEVLD Gene:
UEVLD (UEV and lactate/malate dehyrogenase domains) is a protein-coding gene. Diseases associated with UEVLD include lactate dehydrogenase b deficiency, and pneumonia. GO annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is LDHAL6B.

UniProtKB/Swiss-Prot: UEVLD_HUMAN, Q8IX04
Function: Possible negative regulator of polyubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UEVLD gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   CUTL1   Nkx3-1 v2   Nkx6-1   Nkx3-1 v3   FOXO1a   Hlf   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUEVLD promoter sequence
   Search Chromatin IP Primers for UEVLD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UEVLD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

UEVLD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UEVLD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018554:  view genomic region     (about GC identifiers)

Start:
18,551,156 bp from pter      End:
18,610,294 bp from pter
Size:
59,139 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UEVLD_HUMAN, Q8IX04 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 variant 3  
Size: 471 amino acids; 52264 Da
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for UEVLD:
2I6T (3D)        3DL2 (3D)    
Secondary accessions: B2RB69 B4DL43 F5H6L6 H7BYD6 Q6P2F0 Q96FF5 Q9NUX7
Alternative splicing: 7 isoforms:  Q8IX04-1   Q8IX04-2   Q8IX04-3   Q8IX04-4   Q8IX04-5   Q8IX04-6   Q8IX04-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UEVLD: NX_Q8IX04

Explore proteomics data for UEVLD at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys45
  • Modification sites at PhosphoSitePlus

  • See UEVLD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001035787.1  NP_001248311.1  NP_001248312.1  NP_001248313.1  NP_001248314.1  NP_001248315.1  NP_060784.3  

    ENSEMBL proteins: 
     ENSP00000379500   ENSP00000442974   ENSP00000441092   ENSP00000323353   ENSP00000368697  
     ENSP00000379499   ENSP00000437538   ENSP00000300038  

    UEVLD Human Recombinant Protein Products:

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    Novus Biologicals UEVLD Proteins
    Novus Biologicals UEVLD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UEVLD

    UEVLD Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals UEVLD Antibodies
    Abcam antibodies for UEVLD (A8MYV4, Q8IX04)
    Cloud-Clone Corp. Antibodies for UEVLD
    Search ThermoFisher Antibodies for UEVLD
    LSBio Antibodies in human, mouse, rat for UEVLD

    UEVLD Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for UEVLD
    Cloud-Clone Corp. CLIAs for UEVLD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001236 Lactate/malate_DH_N
     IPR022383 Lactate/malate_DH_C
     IPR008883 UEV_N
     IPR015955 Lactate_DH/Glyco_Ohase_4_C
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q8IX04

    ProtoNet protein and cluster: Q8IX04

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UEVLD_HUMAN, Q8IX04
    Similarity: In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily
    Similarity: In the C-terminal section; belongs to the LDH/MDH superfamily
    Similarity: Contains 1 UEV (ubiquitin E2 variant) domain


    UEVLD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UEVLD_HUMAN, Q8IX04
    Function: Possible negative regulator of polyubiquitination

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity ----
    GO:0016491oxidoreductase activity ----
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA--
         
    UEVLD for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UEVLD:
     Decreased melanin production  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UEVLD
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UEVLD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UEVLD

    miRNA
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    miRTarBase miRNAs that target UEVLD:
    hsa-mir-20a-5p (MIRT050487)

    Block miRNA regulation of human, mouse, rat UEVLD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UEVLD (see all 12):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidUEVLD 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UEVLD
    Predesigned siRNA for gene silencing in human, mouse, rat UEVLD

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for UEVLD

    Clone
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    OriGene clones in human, mouse for UEVLD (see all 13)
    OriGene ORF clones in mouse, rat for UEVLD
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    GenScript: all cDNA clones in your preferred vector (see all 2): UEVLD (NM_001040697)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UEVLD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UEVLD

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for UEVLD 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UEVLD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    UEVLD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UEVLD
    Interactions:

        Search GeneGlobe Interaction Network for UEVLD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UEVLD (Q8IX043 ENSP000003795004) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTX3Q8N9I93, ENSP000003380504I2D: score=2 STRING: ENSP00000338050
    GALMQ96C233, ENSP000002722524I2D: score=1 STRING: ENSP00000272252
    LRSAM1Q6UWE03, ENSP000003004174I2D: score=2 STRING: ENSP00000300417
    RNF114Q9Y5083, ENSP000002440614I2D: score=2 STRING: ENSP00000244061
    RNF4P783173, ENSP000003152124I2D: score=2 STRING: ENSP00000315212
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006464cellular protein modification process IEA--
    GO:0008150biological_process ND--
    GO:0015031protein transport IEA--
    GO:0044262cellular carbohydrate metabolic process IEA--

    UEVLD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UEVLD



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UEVLD gene (8 alternative transcripts): 
    NM_001040698.1  NM_001040697.2  NM_001261382.1  NM_001261383.1  NM_001261384.1  NM_001261385.1  NM_001261386.1  NM_018314.4  

    Unigene Cluster for UEVLD:

    UEV and lactate/malate dehyrogenase domains
    Hs.407991  [show with all ESTs]
    Unigene Representative Sequence: NM_001040697
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396197(uc001mot.3 uc010rde.2 uc010rdf.2) ENST00000543987(uc001mou.3 uc001mov.3)
    ENST00000540666(uc010rdg.2) ENST00000535484 ENST00000320750 ENST00000379387
    ENST00000396196 ENST00000541984 ENST00000539569 ENST00000300038(uc010rdh.2)
    ENST00000540917 ENST00000535340 ENST00000490736
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UEVLD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UEVLD (see all 12):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidUEVLD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UEVLD
    Predesigned siRNA for gene silencing in human, mouse, rat UEVLD
    Clone
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    OriGene clones in human, mouse for UEVLD (see all 13)
    OriGene ORF clones in mouse, rat for UEVLD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UEVLD (NM_001040697)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UEVLD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UEVLD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UEVLD
    OriGene qSTAR qPCR primer pairs in human, mouse for UEVLD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UEVLD
      QuantiTect SYBR Green Assays in human, mouse, rat UEVLD
      QuantiFast Probe-based Assays in human, mouse, rat UEVLD

    Additional mRNA sequence: 

    AF503350.1 AK001930.1 AK295501.1 AK296835.1 AK301537.1 AK314521.1 AK316191.1 BC011011.1 
    BC064566.1 

    9 DOTS entries:

    DT.214043  DT.99953086  DT.100781958  DT.100781959  DT.92420901  DT.102826347  DT.120734215  DT.97786655 
    DT.120741487 

    Selected AceView cDNA sequences (see all 78):

    AL134932 BG258139 AA126211 AK001930 AA278217 BX101129 AI800183 CF138618 
    BM976797 BQ430887 AW572032 CD369413 AA301947 BU633352 AA300647 CR616778 
    AW665551 BG035062 AI183350 BM739516 BQ438957 BC064566 CA443809 AI446097 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UEVLD (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:                                                        -           -     -                                   -                                         -   
    SP2:                                -     -                 -           -     -                                   -                                         -   
    SP3:                                -     -           -     -           -     -                                   -                                         -   
    SP4:                                -     -                 -     -     -     -     -     -     -                 -                 -     -                     
    SP5:                                      -                 -           -     -                                                                                 

    ExUns: 15b ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:        -                           
    SP2:        -                           
    SP3:        -                           
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for UEVLD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UEVLD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACTGAGT
    UEVLD Expression
    About this image

    UEVLD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UEVLD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407991

    UniProtKB/Swiss-Prot: UEVLD_HUMAN, Q8IX04
    Tissue specificity: Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine
    cervix and peripheral blood leukocytes

        Custom PCR Arrays for UEVLD
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    QuantiTect SYBR Green Assays in human, mouse, rat UEVLD
    QuantiFast Probe-based Assays in human, mouse, rat UEVLD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UEVLD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UEVLD gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uevld1 , 5 UEV and lactate/malate dehyrogenase domains1, 5 85(n)1
    83.86(a)1
      7 (30.63 cM)5
    541221  NM_001040695.11  NP_001035785.11 
     469235395 
    chicken
    (Gallus gallus)
    Aves UEVLD1 UEV and lactate/malate dehyrogenase domains 70.37(n)
    70.51(a)
      100858486  NM_001277424.1  NP_001264353.1 
    lizard
    (Anolis carolinensis)
    Reptilia UEVLD6
    UEV and lactate/malate dehyrogenase domains
    67(a)
    1 ↔ 1
    1(67850166-67864236)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123252 Xenopus laevis transcribed sequence with moderate similarity more 73.62(n)    BX853496.1 
    zebrafish
    (Danio rerio)
    Actinopterygii uevld1 UEV and lactate/malate dehyrogenase domains 58.53(n)
    53.16(a)
      445225  NM_001003619.2  NP_001003619.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ImpL36
    CG133346
    --
    34(a)
    25(a)
    many ↔ many
    many ↔ many
    3L(6252265-6255794)
    2R(9446050-9448273)
    worm
    (Caenorhabditis elegans)
    Secernentea ldh-16
    Protein LDH-1 (ldh-1) mRNA, complete cds
    33(a)
    1 → many
    II(11725325-11726532) WBGene00002262


    ENSEMBL Gene Tree for UEVLD (if available)
    TreeFam Gene Tree for UEVLD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UEVLD gene
    LDHAL6B2  LDHB2  LDHAL6A2  LDHA2  LDHC2  
    6 SIMAP similar genes for UEVLD using alignment to 2 protein entries:     UEVLD_HUMAN (see all proteins):
    TSG101    LDHAL6A    LDHB    LDHA    LDHAL6B    LDHC

    UEVLD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UEVLD (see all 1150)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417588881,2
    --18552843(+) AATAAC/TAAAGT 7 -- ds50010--------
    rs1923223771,2
    --18552863(+) GCTGCC/TTGGTA 7 -- ds50010--------
    rs122221541,2
    C,F,H--18552899(+) TACTAT/CTAGTT 7 -- ds500114Minor allele frequency- C:0.17NS EA NA 1942
    rs47576701,2
    C,F,H--18553139(+) ATATAC/TATTTG 7 -- ut3117Minor allele frequency- T:0.03NS NA WA CSA EA 1160
    rs133772811,2
    H--18553278(+) TATTTT/AAAAAA 7 -- ut314Minor allele frequency- A:0.00NS EA 370
    rs1501381411,2
    C--18553448(+) TACAAC/GTGACA 7 -- ut310--------
    rs1842739121,2
    --18553456(+) ACACAC/GATTTT 7 -- ut310--------
    rs1888318641,2
    --18553541(+) CTTATA/CAAATA 7 -- ut310--------
    rs1932236381,2
    --18553551(+) ATTCCC/TGAAGT 7 -- ut310--------
    rs1388410741,2
    --18553607(+) CACTGA/CAGATG 7 -- ut310--------

    HapMap Linkage Disequilibrium report for UEVLD (18551156 - 18610294 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UEVLD:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660842CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UEVLD
    DNA2.0 Custom Variant and Variant Library Synthesis for UEVLD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610985    OMIM disorders: --

    3 diseases for UEVLD:    
    About MalaCards
    lactate dehydrogenase b deficiency    pneumonia    cervicitis


    UEVLD for disorders           About GeneDecksing


    Export disorders for UEVLD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UEVLD gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with UEVLD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of UEV3, a human cDNA with similarities to inactive E2 ubiquitin-conjugating enzymes. (PubMed id 12427560)1, 2, 3, 9 Kloor M....Ridder R. (Biochim. Biophys. Acta 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55293 HGNC: 30866 AceView: UEV3 Ensembl:ENSG00000151116 euGenes: HUgn55293
    ECgene: UEVLD H-InvDB: UEVLD

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UEVLD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UEVLD gene:
    Search GeneIP for patents involving UEVLD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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