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Aliases for UEVLD Gene

Aliases for UEVLD Gene

  • UEV And Lactate/Malate Dehyrogenase Domains 2 3 5
  • EV And Lactate/Malate Dehydrogenase Domain-Containing Protein 3 4
  • UEV-3 3 4
  • UEV3 3 4
  • Signaling Molecule ATTP 3
  • ATTP 3

External Ids for UEVLD Gene

Previous GeneCards Identifiers for UEVLD Gene

  • GC11M018510
  • GC11M018239

Summaries for UEVLD Gene

GeneCards Summary for UEVLD Gene

UEVLD (UEV And Lactate/Malate Dehyrogenase Domains) is a Protein Coding gene. Among its related pathways are protein ubiquitylation. GO annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is LDHC.

UniProtKB/Swiss-Prot for UEVLD Gene

  • Possible negative regulator of polyubiquitination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UEVLD Gene

Genomics for UEVLD Gene

Regulatory Elements for UEVLD Gene

Enhancers for UEVLD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UEVLD on UCSC Golden Path with GeneCards custom track

Promoters for UEVLD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UEVLD on UCSC Golden Path with GeneCards custom track

Genomic Location for UEVLD Gene

Chromosome:
11
Start:
18,529,609 bp from pter
End:
18,588,938 bp from pter
Size:
59,330 bases
Orientation:
Minus strand

Genomic View for UEVLD Gene

Genes around UEVLD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UEVLD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UEVLD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UEVLD Gene

Proteins for UEVLD Gene

  • Protein details for UEVLD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX04-UEVLD_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 variant 3
    Protein Accession:
    Q8IX04
    Secondary Accessions:
    • B2RB69
    • B4DL43
    • F5H6L6
    • H7BYD6
    • Q6P2F0
    • Q96FF5
    • Q9NUX7

    Protein attributes for UEVLD Gene

    Size:
    471 amino acids
    Molecular mass:
    52264 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for UEVLD Gene

    Alternative splice isoforms for UEVLD Gene

neXtProt entry for UEVLD Gene

Proteomics data for UEVLD Gene at MOPED

Post-translational modifications for UEVLD Gene

  • Ubiquitination at Lys 45
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UEVLD Gene

Domains & Families for UEVLD Gene

Graphical View of Domain Structure for InterPro Entry

Q8IX04

UniProtKB/Swiss-Prot:

UEVLD_HUMAN :
  • Contains 1 UEV (ubiquitin E2 variant) domain.
  • In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
Domain:
  • Contains 1 UEV (ubiquitin E2 variant) domain.
Family:
  • In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
  • In the C-terminal section; belongs to the LDH/MDH superfamily.
genes like me logo Genes that share domains with UEVLD: view

No data available for Gene Families for UEVLD Gene

Function for UEVLD Gene

Molecular function for UEVLD Gene

UniProtKB/Swiss-Prot Function:
Possible negative regulator of polyubiquitination.

Gene Ontology (GO) - Molecular Function for UEVLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with UEVLD: view
genes like me logo Genes that share phenotypes with UEVLD: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UEVLD

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UEVLD Gene

Localization for UEVLD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UEVLD Gene COMPARTMENTS Subcellular localization image for UEVLD gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
endoplasmic reticulum 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UEVLD Gene

Pathways & Interactions for UEVLD Gene

SuperPathways for UEVLD Gene

Superpath Contained pathways
1 protein ubiquitylation
genes like me logo Genes that share pathways with UEVLD: view

Pathways by source for UEVLD Gene

1 BioSystems pathway for UEVLD Gene

Gene Ontology (GO) - Biological Process for UEVLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006464 cellular protein modification process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with UEVLD: view

No data available for SIGNOR curated interactions for UEVLD Gene

Drugs & Compounds for UEVLD Gene

No Compound Related Data Available

Transcripts for UEVLD Gene

Unigene Clusters for UEVLD Gene

UEV and lactate/malate dehyrogenase domains:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UEVLD Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: -
SP10: -
SP11: - - - - - - - -
SP12: - - -
SP13:

ExUns: 15b ^ 16 ^ 17a · 17b · 17c · 17d
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for UEVLD Gene

GeneLoc Exon Structure for
UEVLD
ECgene alternative splicing isoforms for
UEVLD

Expression for UEVLD Gene

mRNA expression in normal human tissues for UEVLD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UEVLD Gene

This gene is overexpressed in Urine (24.9) and Cervix (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UEVLD Gene



SOURCE GeneReport for Unigene cluster for UEVLD Gene Hs.407991

mRNA Expression by UniProt/SwissProt for UEVLD Gene

Q8IX04-UEVLD_HUMAN
Tissue specificity: Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with UEVLD: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for UEVLD Gene

Orthologs for UEVLD Gene

This gene was present in the common ancestor of animals.

Orthologs for UEVLD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UEVLD 35
  • 91.3 (n)
  • 92.57 (a)
UEVLD 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UEVLD 35
  • 91.79 (n)
  • 91.93 (a)
UEVLD 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uevld 35
  • 85 (n)
  • 83.86 (a)
Uevld 16
Uevld 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UEVLD 35
  • 99.5 (n)
  • 99.58 (a)
UEVLD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uevld 35
  • 82.87 (n)
  • 82.44 (a)
oppossum
(Monodelphis domestica)
Mammalia UEVLD 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves UEVLD 35
  • 70.37 (n)
  • 70.51 (a)
UEVLD 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UEVLD 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.204 35
uevld 35
  • 61.29 (n)
  • 59.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12325 35
zebrafish
(Danio rerio)
Actinopterygii uevld 35
  • 58.53 (n)
  • 53.16 (a)
uevld 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13334 36
  • 25 (a)
ManyToMany
ImpL3 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ldh-1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 36
  • 33 (a)
OneToMany
Species with no ortholog for UEVLD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UEVLD Gene

ENSEMBL:
Gene Tree for UEVLD (if available)
TreeFam:
Gene Tree for UEVLD (if available)

Paralogs for UEVLD Gene

Paralogs for UEVLD Gene

(6) SIMAP similar genes for UEVLD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UEVLD: view

Variants for UEVLD Gene

Sequence variations from dbSNP and Humsavar for UEVLD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs968711 -- 18,579,787(-) aatgG(A/T)AAACT intron-variant, upstream-variant-2KB
rs968712 -- 18,579,735(-) tgtaa(A/G)aggta intron-variant, upstream-variant-2KB
rs1857907 -- 18,532,790(-) TTTTT(C/G)TTAGC intron-variant
rs2271079 -- 18,541,435(+) TGTCC(C/T)TAGGA intron-variant
rs2271080 -- 18,541,545(+) ACTTA(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UEVLD Gene

Variant ID Type Subtype PubMed ID
esv2660842 CNV Deletion 23128226

Variation tolerance for UEVLD Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UEVLD Gene

Disorders for UEVLD Gene

Relevant External Links for UEVLD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UEVLD

No disorders were found for UEVLD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UEVLD Gene

Publications for UEVLD Gene

  1. Identification and characterization of UEV3, a human cDNA with similarities to inactive E2 ubiquitin-conjugating enzymes. (PMID: 12427560) Kloor M. … Ridder R. (Biochim. Biophys. Acta 2002) 2 3 4 23 67
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3

Products for UEVLD Gene

Sources for UEVLD Gene

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