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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCP3 Gene

protein-coding   GIFtS: 59
GCID: GC11M073711

uncoupling protein 3 (mitochondrial, proton carrier)
 Explore 39 diseases affiliated with
UCP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UCP3    

Aliases
for UCP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Uncoupling Protein 3 (Mitochondrial, Proton Carrier)1 2
SLC25A91 2 3
Solute Carrier Family 25 Member 92 3
UCP 32 3
Mitochondrial Uncoupling Protein 32
Uncoupling Protein-32

External Ids:    HGNC: 125191   Entrez Gene: 73522   Ensembl: ENSG000001755647   OMIM: 6020445   UniProtKB: P559163   

Export aliases for UCP3 gene to outside databases

Previous GC identifers: GC11M076038 GC11M075251 GC11M073934 GC11M073437 GC11M073388 GC11M070007


Summaries
for UCP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UCP3:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins
(MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as
the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial
membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the
mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is
primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against
lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria
exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the
three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.(provided by
RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane,
thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in
the modulation of tissue respiratory control. Participates in thermogenesis and energy balance

Gene Wiki entry for UCP3


Genomic Views
for UCP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCP3 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UCP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

UCP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCP3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073711:  view genomic region     (about GC identifiers)

Start:
 73,711,326 bp from pter      End:
 73,720,480 bp from pter
Size:
 9,155 bases      Orientation:
 minus strand

Proteins
for UCP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916 (See protein sequence)
Recommended Name: Mitochondrial uncoupling protein 3  
Size: 312 amino acids; 34216 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAC51785.1; Type=Erroneous initiation;
Secondary accessions: O60475 Q96HL3
Alternative splicing: 3 isoforms:  P55916-1   P55916-2   P55916-3   

Explore the universe of human proteins at neXtProt for UCP3: NX_P55916

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55916

    • UCP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003347.1  NP_073714.1  

    ENSEMBL proteins: 
     ENSP00000323740   ENSP00000392143   ENSP00000445279   ENSP00000343615  
    Reactome Protein details: P55916
    Human Recombinant Protein Products: 
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    Novus Biologicals UCP3 Protein
    Novus Biologicals UCP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UCP3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS9180264
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031966mitochondrial membrane ----


    UCP3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UCP3

    Protein Domains /
    Families
    for UCP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UCP3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023395 Mt_carrier_dom
     IPR002030 Mit_uncoupling
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry P55916

    ProtoNet protein and cluster: P55916

    1 Blocks protein family: IPB002030 Mitochondrial brown fat uncoupling protein signature

    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    Function
    for UCP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
    Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane,
    thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in
    the modulation of tissue respiratory control. Participates in thermogenesis and energy balance

         Genatlas biochemistry entry for UCP3:
    uncoupling protein of inner mitochondrial membrane 3,with two forms,long and short missing C terminal 37
    residues,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly
    expressed in skeletal muscle during development,regulated by nutritional factors,possible mediator of adaptive
    thermogenesis,involved in the variation of energy metabolism and obesity,regulated by PPARA and PPARG in mice,and
    dysregulated in states of insulin resistance,increased expression in function of obesity and in type 2 diabetes
    (NIDDM)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCP3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate UCP3 (see all 40):
    hsa-miR-3607-3p hsa-miR-3655 hsa-miR-330-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-650 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmid: UCP3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCP3 (see all 7)
    OriGene shRNA RFP: UCP3
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UCP3 (see all 4)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9196039
    GO:0017077oxidative phosphorylation uncoupler activity IEA--


    UCP3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for UCP3: Ucp3tm1Rei Ucp3tm1Brnd Ucp3tm1Lowl
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ucp3):
     adipose tissue  cellular  growth/size  homeostasis/metabolism 

    UCP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UCP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1The fatty acid cycling model
    		Mitochondrial Uncoupling Proteins1.00
    		The proton buffering model1.00
    		The fatty acid cycling model1.00
    		Energy Metabolism0.04
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
    		The citric acid (TCA) cycle and respiratory electron transport0.72
    		Electron Transport Chain0.76
    3Metabolism
    		Metabolism1.00
    4Selected targets of GCR-alpha
    		Selected targets of GCR-alpha1.00
    5Selected targets of C/EBPbeta
    		Selected targets of C/EBPbeta1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for UCP3
        Selected targets of C/EBPbeta
    Selected targets of GCR-alpha


    3 BioSystems Pathways for UCP3 
        Diurnally regulated genes with circadian orthologs
    Energy Metabolism
    Electron Transport Chain

    5/6        Reactome Pathways for UCP3 (see all 6)
        The proton buffering model
    Mitochondrial Uncoupling Proteins
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport



    UCP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCP3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for UCP3 (P559163 ENSP000003237404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463, ENSP000003001614I2D: score=3 STRING: ENSP00000300161
    YWHAGP619813, ENSP000003063304I2D: score=2 STRING: ENSP00000306330
    YWHAQP273483, ENSP000002380814I2D: score=4 STRING: ENSP00000238081
    YWHAZP631043, ENSP000003095034I2D: score=4 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000303response to superoxide IEA--
    GO:0001666response to hypoxia IEA--
    GO:0006629lipid metabolic process TAS10935638
    GO:0006631fatty acid metabolic process IEA--
    GO:0006839mitochondrial transport IEA--


    UCP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UCP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UCP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCP3
    10/42 Novoseek chemical compound relationships for UCP3 gene (see all 42)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 71.3 114 14525936 (5), 15294045 (5), 14671191 (4), 15814607 (4) (see all 45)
    etomoxir 64 6 11470240 (2), 11511517 (1), 16306367 (1), 12206997 (1)
    carnitine 54.5 13 16092055 (2), 12540388 (1), 19448714 (1), 14761878 (1) (see all 9)
    atp 54.5 35 11511517 (2), 17030788 (2), 15024403 (1), 9769326 (1) (see all 22)
    glucose 49.5 75 11278970 (6), 18167556 (5), 11511517 (4), 19283340 (3) (see all 34)
    carbacyclin 48.8 1 10567719 (1)
    hydrogen 47.9 24 12145158 (4), 11707458 (2), 18059613 (2), 16005426 (1) (see all 13)
    pyruvate 46.6 14 16092055 (2), 19448714 (1), 14761878 (1), 15932964 (1) (see all 9)
    oxygen 46 21 16968671 (3), 16046300 (2), 16005426 (1), 17303124 (1) (see all 13)
    acipimox 44.7 1 17186295 (1)

    Search CenterWatch for drugs/clinical trials and news about UCP3 

    Transcripts
    for UCP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UCP3 gene (2 alternative transcripts): 
    NM_003356.3  NM_022803.2  

    Unigene Cluster for UCP3:

    Uncoupling protein 3 (mitochondrial, proton carrier)
    Hs.101337  [show with all ESTs]
    Unigene Representative Sequence: NM_003356
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314032(uc001our.3) ENST00000545271 ENST00000426995(uc001ous.2)
    ENST00000544614 ENST00000348534

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCP3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate UCP3 (see all 40):
    hsa-miR-3607-3p hsa-miR-3655 hsa-miR-330-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-650 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmid: UCP3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCP3 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF001787.1 AF011449.1 AK092685.1 AK290630.1 AK291889.1 AK309873.1 BC008392.1 U82818.1 
    U84763.1 

    6 DOTS entries:

    DT.100736825  DT.208463  DT.99927646  DT.40252962  DT.120718117  DT.97763855 

    24/38 AceView cDNA sequences (see all 38):

    U82818 BU739937 NM_022803 AW295096 U84763 AF001787 BQ446444 BG236319 
    NM_003356 BC008392 AI670961 BM715026 BF507985 AA192136 Z25295 Z28895 
    AK092685 CD616918 AA779805 BU618868 AF011449 AA192553 AW770912 BE844207 

    GeneLoc Exon Structure


    Expression
    for UCP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTACCTCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See UCP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCP3

    SOURCE GeneReport for Unigene cluster: Hs.101337

    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
    Tissue specificity: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal
    muscles

        SABiosciences Expression via Pathway-Focused PCR Arrays including UCP3: 
              Mitochondrial Energy Metabolism in human mouse rat
              Mitochondria in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP3

    Orthologs
    for UCP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UCP3 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UCP31 uncoupling protein 3 (mitochondrial, proton carrier) less 72.11(n)
    73.67(a)    		   373896  NM_204107.1  NP_989438.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UCP36
    		 --
    		 77(a)
    		 1 ↔ 1
    		 GL343978.1(67840-84185)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc558242 similar to uncoupling protein 3 (mitochondrial, proton carrier) less 78.45(n)   394186  AY398428.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 51(a)
    		 1 → many
    		 Group1.55(8274-14166)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UCP21 uncoupling protein 2 50.46(n)
    46.23(a)    		   836014  NM_125287.4  NP_568894.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 mitochondrial carrier protein, putative, expressed...
    mitochondrial carrier protein, putative, expressed...
    (see all 3)    		 47(a)
    44(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 11(28437935-28441880)
    1(43224915-43229546)


    ENSEMBL Gene Tree for UCP3 (if available)
    TreeFam Gene Tree for UCP3 (if available) 

    Paralogs
    for UCP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UCP3 gene
    UCP12  UCP22  SLC25A142  SLC25A112  ENSG000002626602  SLC25A102  SLC25A302  SLC25A272  
    10 SIMAP similar genes for UCP3 using alignment to 3 protein entries:     UCP3_HUMAN (see all proteins):
    UCP2    SLC25A14    UCP1    SLC25A30    SLC25A11    SLC25A10
    SLC25A34    SLC25A27    SLC25A19    FLJ00351

    UCP3 for paralogs           About GeneDecksing



    Genomic Variants
    for UCP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/264 NCBI SNPs in UCP3 are shown (see all 264)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048943191,2
    		C,F,pathogenic73716889(-) AGGTCC/TGATTT 4 R * stg12Minor allele frequency- T:0.00NA EU 5875
    rs22297071,2
    		C,F,H,pathogenic73717247(-) ACTCCG/ATCAAG 4 /I /V mis1 ese313Minor allele frequency- A:0.04MN NS EA NA WA CSA EU 6422
    rs178483681,2
    		Cpathogenic73717343(-) TGGTGC/TGGACT 4 R W mis1 ese32Minor allele frequency- T:0.00NA 4
    rs79304601,2
    		C,F,H,--73710886(+) GGTCAA/GCCCTC 1 -- int128Minor allele frequency- G:0.23EA NA NS WA 2982
    rs1380252191,2
    		--73710945(+) ACACCA/GAGGTG 1 -- int10--------
    rs1435196261,2
    		--73710963(+) TCCCTA/GTGGCT 1 -- int10--------
    rs802011511,2
    		--73711018(+) TGACAA/CTCATC 1 -- int10--------
    rs6324371,2
    		C,H--73711027(+) TCAGAG/CCTACG 1 -- int15Minor allele frequency- C:0.00MN NS EA 594
    rs1386386651,2
    		--73711032(+) GCTACA/GCAAGG 1 -- int10--------
    rs1492351681,2
    		--73711059(+) AAAGAC/TAGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for UCP3 (73711326 - 73720480 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UCP3: --
    Human Gene Mutation Database (HGMD): UCP3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UCP3
    DNA2.0 Custom Variant and Variant Library Synthesis for UCP3

    Disorders / Diseases
    for UCP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UCP3 for disorders           About GeneDecksing

    OMIM gene information: 602044   
    OMIM disorders: 601665  
    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
  • Defects in UCP3 may be involved in obesity (OBESITY) [MIM:601665]. It is a condition characterized by an
    • increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive
    accumulation of body fat

    20/39 diseases for UCP3 (see all 39):    About MalaCards
    obesity, severe, and type ii diabetes    amyotrophic lateral sclerosis    growth hormone deficiency    type 2 diabetes mellitus
    lateral sclerosis    chronic obstructive pulmonary disease    sleep apnea    insulin resistance
    metabolic disorders    anorexia nervosa    fatty liver disease    obesity, variation in
    coronary heart disease    diabetes mellitus    morbid obesity    obesity
    pulmonary disease    apnea    hyperlipidemia    myocardial infarction

    1 disease from the University of Copenhagen DISEASES database for UCP3:
    Diabetes mellitus

    10/16 Novoseek disease relationships for UCP3 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 70.2 99 11319649 (3), 16006788 (3), 18059082 (3), 17598332 (3) (see all 61)
    insulin sensitivity 49.3 11 12153598 (2), 18059082 (2), 19468707 (1), 10403804 (1) (see all 8)
    insulin resistance 45.2 13 16046300 (3), 19913848 (1), 17828388 (1), 18220632 (1) (see all 10)
    niddm 39.7 13 9726246 (5), 17150099 (1), 11151767 (1), 11484071 (1) (see all 9)
    hyperinsulinemia 32.7 4 19875988 (1), 9511737 (1), 10615946 (1)
    metabolic disorder 32.3 4 10395193 (1), 11080246 (1), 10618503 (1), 11237725 (1)
    impaired glucose tolerance 23.5 5 17587402 (1), 19769793 (1), 19782153 (1), 16384852 (1)
    hyperlipidemia 7.16 1 10868951 (1)
    cancer 0.781 2 16337086 (1), 15334872 (1)
    tumors 0.772 4 11278795 (1), 10868951 (1), 19680556 (1), 16741147 (1)

    Genetic Association Database (GAD): UCP3
    Human Genome Epidemiology (HuGE) Navigator: UCP3 (83 documents)

    Export disorders for UCP3 gene to outside databases

    Publications
    for UCP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCP3 gene, integrated from 9 sources (see all 379):
    (articles sorted by number of sources associating them with UCP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. (PubMed id 9196039)1, 2, 3, 9 Vidal-Puig A.... Lowell B.B. (1997)
    2. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. (PubMed id 16373902)1, 4, 9 Rudofsky G....Hamann A. (2006)
    3. The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. (PubMed id 9325252)1, 2, 9 Solanes G.... Lowell B.B. (1997)
    4. Association of UCP3 gene -55C>T polymorphism and obesity in a Spanish population. (PubMed id 16006788)1, 4, 9 Alonso A....Martinez J.A. (2005)
    5. Association between uncoupling protein 3 gene and obesity-related phenotypes in the Quebec Family Study. (PubMed id 11683368)1, 4, 9 Lanouette C.M....Chagnon Y.C. (2001)
    6. Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population. (PubMed id 11319649)1, 4, 9 Halsall D.J....O'Rahilly S. (2001)
    7. A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population. (PubMed id 11238538)1, 4, 9 Dalgaard L.T....Pedersen O. (2001)
    8. The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents. (PubMed id 10958796)1, 2, 9 Esterbauer H.... Patsch W. (2000)
    9. Effect of polymorphism of uncoupling protein 3 gene -55 (C>T) on the resting energy expenditure, total body fat and regional body fat in Chinese. (PubMed id 16215931)1, 4, 9 Fang Q.C....Xiang K.S. (2005)
    10. Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. (PubMed id 15978856)1, 4, 9 Meirhaeghe A....Dallongeville J. (2005)

    External Searches for UCP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing UCP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7352 HGNC: 12519 AceView: UCP3 Ensembl:ENSG00000175564 euGenes: HUgn7352
    ECgene: UCP3 H-InvDB: UCP3

    Other Databases showing UCP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UCP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCP3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UCP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UCP3 gene:
    Search GeneIP for patents involving UCP3

    GeneCards and IP:
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    About This Section

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