Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCP3 Gene

protein-coding   GIFtS: 60
GCID: GC11M073711

Uncoupling Protein 3 (Mitochondrial, Proton Carrier)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Uncoupling Protein 3 (Mitochondrial, Proton Carrier)1 2
Solute Carrier Family 25 Member 92 3
SLC25A92 3
Mitochondrial Uncoupling Protein 32
UCP 33

External Ids:    HGNC: 125191   Entrez Gene: 73522   Ensembl: ENSG000001755647   OMIM: 6020445   UniProtKB: P559163   

Export aliases for UCP3 gene to outside databases

Previous GC identifers: GC11M076038 GC11M075251 GC11M073934 GC11M073437 GC11M073388 GC11M070007


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCP3 Gene:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins
(MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred
to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer
mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane.
They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific
expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to
protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty
acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids
from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants
have been found for this gene.(provided by RefSeq, Nov 2008)

GeneCards Summary for UCP3 Gene: 
UCP3 (uncoupling protein 3 (mitochondrial, proton carrier)) is a protein-coding gene. Diseases associated with UCP3 include obesity, variation in, and obesity, severe, and type ii diabetes, and among its related super-pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and The proton buffering model. GO annotations related to this gene include oxidative phosphorylation uncoupler activity and transporter activity. An important paralog of this gene is UCP1.

UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May
play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance

Gene Wiki entry for UCP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCP3 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

UCP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCP3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073711:  view genomic region     (about GC identifiers)

Start:
73,711,326 bp from pter      End:
73,720,480 bp from pter
Size:
9,155 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916 (See protein sequence)
Recommended Name: Mitochondrial uncoupling protein 3  
Size: 312 amino acids; 34216 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAC51785.1; Type=Erroneous initiation;
Secondary accessions: O60475 Q96HL3
Alternative splicing: 3 isoforms:  P55916-1   P55916-2   P55916-3   

Explore the universe of human proteins at neXtProt for UCP3: NX_P55916

Explore proteomics data for UCP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55916

  • UCP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UCP3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003347.1  NP_073714.1  

    ENSEMBL proteins: 
     ENSP00000323740   ENSP00000392143   ENSP00000445279   ENSP00000343615  
    Reactome Protein details: P55916
    Human Recombinant Protein Products for UCP3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UCP3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for UCP3
    GenScript Custom Purified and Recombinant Proteins Services for UCP3
    Novus Biologicals UCP3 Protein
    Novus Biologicals UCP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UCP3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS9180264
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031966mitochondrial membrane ----

    UCP3 for ontologies           About GeneDecksing



    UCP3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of UCP3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UCP3
    OriGene Custom Antibody Services for UCP3
    GenScript Custom Superior Antibodies Services for UCP3
    Novus Biologicals UCP3 Antibodies
    Abcam antibodies for UCP3
    Cloud-Clone Corp. Antibodies for UCP3 
    ThermoFisher Antibodies for UCP3
    LSBio Antibodies in human, mouse, rat for UCP3 

    Assay Products for UCP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UCP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UCP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UCP3 
    Cloud-Clone Corp. CLIAs for UCP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Uncoupling protein 3 
    Mitochondrial uncoupling proteins

    3 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR002030 Mit_uncoupling
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry P55916

    ProtoNet protein and cluster: P55916

    1 Blocks protein domain: IPB002030 Mitochondrial brown fat uncoupling protein signature

    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    UCP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCP3_HUMAN, P55916
    Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
    membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May
    play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance

         Genatlas biochemistry entry for UCP3:
    uncoupling protein of inner mitochondrial membrane 3,with two forms,long and short missing C terminal 37
    residues,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP
    conversion,highly expressed in skeletal muscle during development,regulated by nutritional factors,possible
    mediator of adaptive thermogenesis,involved in the variation of energy metabolism and obesity,regulated by PPARA
    and PPARG in mice,and dysregulated in states of insulin resistance,increased expression in function of obesity
    and in type 2 diabetes (NIDDM)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9196039
    GO:0017077oxidative phosphorylation uncoupler activity IEA--
         
    UCP3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ucp3):
     adipose tissue  cellular  growth/size  homeostasis/metabolism 

    UCP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for UCP3: Ucp3tm1Rei Ucp3tm1Brnd Ucp3tm1Lowl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UCP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UCP3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCP3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate UCP3 (see all 40):
    hsa-miR-3607-3p hsa-miR-3655 hsa-miR-330-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-650 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidUCP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UCP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UCP3
    Sirion Biotech Customized adenovirus for overexpression of UCP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UCP3 (see all 13)
    OriGene ORF clones in mouse, rat for UCP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UCP3 (NM_003356)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCP3
    Sirion Biotech Customized lentivirus for stable overexpression of UCP3 
                         Customized lentivirus expression plasmids for stable overexpression of UCP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UCP3
    Search LifeMap BioReagents cell lines for UCP3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UCP3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Electron Transport Chain0.75
    2The fatty acid cycling model
    Mitochondrial Uncoupling Proteins1.00
    The fatty acid cycling model1.00
    The proton buffering model1.00
    3Metabolism
    Metabolism0.40
    4Selected targets of GCR-alpha
    Selected targets of GCR-alpha
    5Selected targets of C/EBPbeta
    Selected targets of C/EBPbeta

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for UCP3
        Selected targets of C/EBPbeta
    Selected targets of GCR-alpha


    3 BioSystems Pathways for UCP3
        Diurnally regulated genes with circadian orthologs
    Electron Transport Chain
    Energy Metabolism

    5/6        Reactome Pathways for UCP3 (see all 6)
        The proton buffering model
    Mitochondrial Uncoupling Proteins
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport



    UCP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCP3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for UCP3 (P559163 ENSP000003237404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463, ENSP000003001614I2D: score=3 STRING: ENSP00000300161
    YWHAGP619813, ENSP000003063304I2D: score=2 STRING: ENSP00000306330
    YWHAQP273483, ENSP000002380814I2D: score=4 STRING: ENSP00000238081
    YWHAZP631043, ENSP000003095034I2D: score=4 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000303response to superoxide IEA--
    GO:0001666response to hypoxia IEA--
    GO:0006629lipid metabolic process TAS10935638
    GO:0006631fatty acid metabolic process IEA--
    GO:0006839mitochondrial transport IEA--

    UCP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UCP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCP3

    10/42 Novoseek inferred chemical compound relationships for UCP3 gene (see all 42)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 71.3 114 14525936 (5), 15294045 (5), 14671191 (4), 15814607 (4) (see all 45)
    etomoxir 64 6 11470240 (2), 11511517 (1), 16306367 (1), 12206997 (1)
    carnitine 54.5 13 16092055 (2), 12540388 (1), 19448714 (1), 14761878 (1) (see all 9)
    atp 54.5 35 11511517 (2), 17030788 (2), 15024403 (1), 9769326 (1) (see all 22)
    glucose 49.5 75 11278970 (6), 18167556 (5), 11511517 (4), 19283340 (3) (see all 34)
    carbacyclin 48.8 1 10567719 (1)
    hydrogen 47.9 24 12145158 (4), 11707458 (2), 18059613 (2), 16005426 (1) (see all 13)
    pyruvate 46.6 14 16092055 (2), 19448714 (1), 14761878 (1), 15932964 (1) (see all 9)
    oxygen 46 21 16968671 (3), 16046300 (2), 16005426 (1), 17303124 (1) (see all 13)
    acipimox 44.7 1 17186295 (1)

    Search CenterWatch for drugs/clinical trials and news about UCP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UCP3 gene (2 alternative transcripts): 
    NM_003356.3  NM_022803.2  

    Unigene Cluster for UCP3:

    Uncoupling protein 3 (mitochondrial, proton carrier)
    Hs.101337  [show with all ESTs]
    Unigene Representative Sequence: NM_003356
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314032(uc001our.3) ENST00000545271 ENST00000426995(uc001ous.2)
    ENST00000544614 ENST00000348534
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCP3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate UCP3 (see all 40):
    hsa-miR-3607-3p hsa-miR-3655 hsa-miR-330-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-650 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidUCP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UCP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCP3
    Clone
    Products:
         
    OriGene clones in human, mouse for UCP3 (see all 13)
    OriGene ORF clones in mouse, rat for UCP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UCP3 (NM_003356)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCP3
    Sirion Biotech Customized lentivirus for stable overexpression of UCP3 
                         Customized lentivirus expression plasmids for stable overexpression of UCP3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UCP3
    OriGene qSTAR qPCR primer pairs in human, mouse for UCP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UCP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCP3

    Additional mRNA sequence: 

    AF001787.1 AF011449.1 AK092685.1 AK290630.1 AK291889.1 AK309873.1 BC008392.1 U82818.1 
    U84763.1 

    6 DOTS entries:

    DT.100736825  DT.208463  DT.99927646  DT.40252962  DT.120718117  DT.97763855 

    24/38 AceView cDNA sequences (see all 38):

    U84763 AF001787 BU739937 U82818 AW295096 NM_022803 NM_003356 Z28895 
    Z25295 BQ446444 AI670961 BC008392 AF011449 AK092685 AA779805 BF507985 
    BM715026 BG236319 CD616918 BU618868 AA192136 AI968020 BF670349 BV180624 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCP3 expression in normal human tissues (normalized intensities)      UCP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTACCTCAA
    UCP3 Expression
    About this image


    UCP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             gastrocnemius   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Lung (Respiratory System)
             bronchoalveolar lavage cells   
     
     Ovary (Reproductive System)

    See UCP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCP3

    SOURCE GeneReport for Unigene cluster: Hs.101337

    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
    Tissue specificity: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal
    muscles

        SABiosciences Expression via Pathway-Focused PCR Arrays including UCP3: 
              Mitochondrial Energy Metabolism in human mouse rat
              Mitochondria in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UCP3
    OriGene qSTAR qPCR primer pairs in human, mouse for UCP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UCP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UCP3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ucp31 , 5 uncoupling protein 3 (mitochondrial, proton carrier) less1, 5 85.17(n)1
    86.69(a)1
      7 (54.36 cM)5
    222291  NM_009464.31  NP_033490.11 
     1004729905 
    chicken
    (Gallus gallus)
    Aves UCP31 uncoupling protein 3 (mitochondrial, proton carrier) less 72.11(n)
    73.67(a)
      373896  NM_204107.1  NP_989438.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558242 similar to uncoupling protein 3 (mitochondrial, proton carrier) less 78.45(n)   394186  AY398428.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIC16
    Mitochondrial dicarboxylate carrier, integral memb...
    30(a)
    1 → many
    XII(826977-827873)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UCP21 uncoupling protein 2 50.46(n)
    46.23(a)
      836014  NM_125287.4  NP_568894.1 


    ENSEMBL Gene Tree for UCP3 (if available)
    TreeFam Gene Tree for UCP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UCP3 gene
    UCP12  UCP22  SLC25A142  SLC25A112  ENSG000002626602  SLC25A102  SLC25A302  SLC25A272  
    9 SIMAP similar genes for UCP3 using alignment to 3 protein entries:     UCP3_HUMAN (see all proteins):
    UCP2    SLC25A14    UCP1    SLC25A30    SLC25A11    SLC25A10
    SLC25A34    SLC25A27    SLC25A19

    UCP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/334 SNPs in UCP3 are shown (see all 334)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22297071,2,4
    C,F,HObesity (OBESITY)4 pathogenic173582870(-) ACTCCG/ATCAAG 4 /I /V mis1 ese313Minor allele frequency- A:0.04MN NS EA NA WA CSA EU 6422
    rs1048943191,2
    C,Fpathogenic173582512(-) AGGTCC/TGATTT 4 R * stg12Minor allele frequency- T:0.00NA EU 5875
    rs178483681,2,4
    Cpathogenic173582966(-) TGGTGC/TGGACT 4 R W mis1 ese32Minor allele frequency- T:0.00NA 4
    rs79304601,2
    C,F,H--73576507(+) GGTCAA/GCCCTC 1 -- int128Minor allele frequency- G:0.23EA NA NS WA 2982
    rs1380252191,2
    --73576566(+) ACACCA/GAGGTG 1 -- int10--------
    rs1435196261,2
    --73576584(+) TCCCTA/GTGGCT 1 -- int10--------
    rs802011511,2
    F--73576639(+) TGACAA/CTCATC 1 -- int10--------
    rs6324371,2
    C,H--73576648(+) TCAGAG/CCTACG 1 -- int15Minor allele frequency- C:0.00MN NS EA 594
    rs1386386651,2
    --73576653(+) GCTACA/GCAAGG 1 -- int10--------
    rs1492351681,2
    --73576680(+) AAAGAC/TAGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for UCP3 (73711326 - 73720480 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UCP3: --

    Human Gene Mutation Database (HGMD): UCP3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UCP3
    DNA2.0 Custom Variant and Variant Library Synthesis for UCP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602044   
    OMIM disorders: 601665  
    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the
    limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=The
    gene represented in this entry may be involved in disease pathogenesis

  • 20/32 diseases for UCP3 (see all 32):    About MalaCards
    obesity, variation in    obesity, severe, and type ii diabetes    obesity    morbid obesity
    diabetic neuropathy    obesity, association with    insulin resistance    sleep apnea
    growth hormone deficiency    metabolic disorders    anorexia nervosa    fatty liver disease
    lateral sclerosis    amyotrophic lateral sclerosis    insulinoma    chronic obstructive pulmonary disease
    hyperglycemia    liver disease    atherosclerosis    coronary heart disease

    1 disease from the University of Copenhagen DISEASES database for UCP3:
    Diabetes mellitus

    UCP3 for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for UCP3 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 70.2 99 11319649 (3), 16006788 (3), 18059082 (3), 17598332 (3) (see all 61)
    insulin sensitivity 49.3 11 12153598 (2), 18059082 (2), 19468707 (1), 10403804 (1) (see all 8)
    insulin resistance 45.2 13 16046300 (3), 19913848 (1), 17828388 (1), 18220632 (1) (see all 10)
    niddm 39.7 13 9726246 (5), 17150099 (1), 11151767 (1), 11484071 (1) (see all 9)
    hyperinsulinemia 32.7 4 19875988 (1), 9511737 (1), 10615946 (1)
    metabolic disorder 32.3 4 10395193 (1), 11080246 (1), 10618503 (1), 11237725 (1)
    impaired glucose tolerance 23.5 5 17587402 (1), 19769793 (1), 19782153 (1), 16384852 (1)
    hyperlipidemia 7.16 1 10868951 (1)
    cancer 0.781 2 16337086 (1), 15334872 (1)
    tumors 0.772 4 11278795 (1), 10868951 (1), 19680556 (1), 16741147 (1)

    Genetic Association Database (GAD): UCP3
    Human Genome Epidemiology (HuGE) Navigator: UCP3 (83 documents)

    Export disorders for UCP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCP3 gene, integrated from 9 sources (see all 388):
    (articles sorted by number of sources associating them with UCP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. (PubMed id 9196039)1, 2, 3, 9 Vidal-Puig A.... Lowell B.B. (1997)
    2. Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men. (PubMed id 19155787)1, 4, 9 Matsunaga T....Nishiyama T. (2009)
    3. Modulation of adipocytokines response and weight loss secondary to a hypocaloric diet in obese patients by -55CT polymorphism of UCP3 gene. (PubMed id 18348082)1, 4, 9 de Luis D.A....Conde R. (2008)
    4. Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes. (PubMed id 18426825)1, 4, 9 van Abeelen A.F....van der Schouw Y.T. (2008)
    5. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. (PubMed id 16373902)1, 4, 9 Rudofsky G....Hamann A. (2006)
    6. The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. (PubMed id 9325252)1, 2, 9 Solanes G.... Lowell B.B. (1997)
    7. Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women. (PubMed id 17512314)1, 4, 9 Cha M.H....Yoon Y. (2007)
    8. Association of UCP3 gene -55C>T polymorphism and obesity in a Spanish population. (PubMed id 16006788)1, 4, 9 Alonso A....Martinez J.A. (2005)
    9. Association between uncoupling protein 3 gene and obesity-related phenotypes in the Quebec Family Study. (PubMed id 11683368)1, 4, 9 Lanouette C.M....Chagnon Y.C. (2001)
    10. Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population. (PubMed id 11319649)1, 4, 9 Halsall D.J....O'Rahilly S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7352 HGNC: 12519 AceView: UCP3 Ensembl:ENSG00000175564 euGenes: HUgn7352
    ECgene: UCP3 H-InvDB: UCP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UCP3 gene:
    Search GeneIP for patents involving UCP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UCP3
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UCP3   OriGene RNAi products in human, mouse, rat for UCP3  
     OriGene qPCR primer pairs and template standards for UCP3   OriGene Protein Over-expression Lysate for UCP3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UCP3  
     OriGene qSTAR qPCR primer pairs in human, mouse for UCP3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UCP3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UCP3   OriGene Custom Protein Services for UCP3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UCP3
     QIAGEN SeqTarget long-range PCR primers for resequencing UCP3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCP3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCP3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCP3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCP3
     GenScript Custom Purified and Recombinant Proteins Services for UCP3 GenScript cDNA clones with any tag delivered in your preferred vector for UCP3
     GenScript Custom Assay Services for UCP3 GenScript Custom Superior Antibodies Services for UCP3
     GenScript Custom overexpressing Cell Line Services for UCP3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UCP3 promoter
     Search Chromatin IP Primers for UCP3
     RT2 qPCR Primer Assay in human, mouse, rat UCP3
     GNC Network for UCP3
     SABiosciences PCR Arrays including human, mouse, rat UCP3
     Search Tocris compounds for UCP3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UCP3 antibodies
     UCP3 proteins
     UCP3 lysates
     Antibodies for UCP3
     See all of Abcam's Antibodies, Kits and Proteins for UCP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UCP3
     Antibodies for UCP3
     ELISAs for UCP3
     CLIAs for UCP3
     Search LifeMap BioReagents cell lines for UCP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP3
     SwitchGear 3'UTR luciferase reporter plasmids for UCP3
     SwitchGear Promoter luciferase reporter plasmids for UCP3
     ThermoFisher Antibodies for UCP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCP3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UCP3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCP3
    Customized:
     lentivirus for stable overexpression of UCP3
     lentivirus expression plasmids for stable overexpression of UCP3
     adenovirus for overexpression of UCP3
     LSBio Antibodies in human, mouse, rat for UCP3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UCP3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4