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Aliases for UCP3 Gene

Aliases for UCP3 Gene

  • Uncoupling Protein 3 (Mitochondrial, Proton Carrier) 2 3
  • Solute Carrier Family 25 Member 9 3 4
  • SLC25A9 3 4
  • Mitochondrial Uncoupling Protein 3 3
  • UCP 3 4

External Ids for UCP3 Gene

Previous GeneCards Identifiers for UCP3 Gene

  • GC11M076038
  • GC11M075251
  • GC11M073934
  • GC11M073437
  • GC11M073388
  • GC11M073711
  • GC11M070007

Summaries for UCP3 Gene

Entrez Gene Summary for UCP3 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

GeneCards Summary for UCP3 Gene

UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier)) is a Protein Coding gene. Diseases associated with UCP3 include obesity, ucp3-related and obesity. Among its related pathways are Metabolism and Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include transporter activity and oxidative phosphorylation uncoupler activity. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for UCP3 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance

Gene Wiki entry for UCP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP3 Gene

Genomics for UCP3 Gene

Regulatory Elements for UCP3 Gene

Genomic Location for UCP3 Gene

74,000,281 bp from pter
74,009,435 bp from pter
9,155 bases
Minus strand

Genomic View for UCP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCP3 Gene

Proteins for UCP3 Gene

  • Protein details for UCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial uncoupling protein 3
    Protein Accession:
    Secondary Accessions:
    • O60475
    • Q96HL3

    Protein attributes for UCP3 Gene

    312 amino acids
    Molecular mass:
    34216 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC51785.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UCP3 Gene


neXtProt entry for UCP3 Gene

Proteomics data for UCP3 Gene at MOPED

Post-translational modifications for UCP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UCP3 Gene

Domains for UCP3 Gene

Gene Families for UCP3 Gene

Suggested Antigen Peptide Sequences for UCP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • P55916
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with UCP3: view

Function for UCP3 Gene

Molecular function for UCP3 Gene

GENATLAS Biochemistry:
uncoupling protein of inner mitochondrial membrane 3,with two forms,long and short missing C terminal 37 residues,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in skeletal muscle during development,regulated by nutritional factors,possible mediator of adaptive thermogenesis,involved in the variation of energy metabolism and obesity,regulated by PPARA and PPARG in mice,and dysregulated in states of insulin resistance,increased expression in function of obesity and in type 2 diabetes (NIDDM)
UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance

Gene Ontology (GO) - Molecular Function for UCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9196039
GO:0005515 protein binding IPI 24008843
GO:0017077 oxidative phosphorylation uncoupler activity IEA --
genes like me logo Genes that share ontologies with UCP3: view
genes like me logo Genes that share phenotypes with UCP3: view

Animal Models for UCP3 Gene

MGI Knock Outs for UCP3:

Animal Model Products

miRNA for UCP3 Gene

miRTarBase miRNAs that target UCP3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for UCP3 Gene

Localization for UCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCP3 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for UCP3 Gene COMPARTMENTS Subcellular localization image for UCP3 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for UCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 9180264
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane --
genes like me logo Genes that share ontologies with UCP3: view

Pathways for UCP3 Gene

genes like me logo Genes that share pathways with UCP3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondria in human,mouse,rat
    • Mitochondrial Energy Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for UCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000303 response to superoxide IEA --
GO:0001666 response to hypoxia IEA --
GO:0006629 lipid metabolic process TAS 10935638
GO:0006631 fatty acid metabolic process IEA --
GO:0006839 mitochondrial transport IEA --
genes like me logo Genes that share ontologies with UCP3: view

Compounds for UCP3 Gene

(42) Novoseek inferred chemical compound relationships for UCP3 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 71.3 85
etomoxir 64 5
carnitine 54.5 10
atp 54.5 24
glucose 49.5 54
genes like me logo Genes that share compounds with UCP3: view

Transcripts for UCP3 Gene

Unigene Clusters for UCP3 Gene

Uncoupling protein 3 (mitochondrial, proton carrier):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCP3 Gene

No ASD Table

Relevant External Links for UCP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCP3 Gene

mRNA expression in normal human tissues for UCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCP3 Gene

This gene is overexpressed in Muscle - Skeletal (40.9).

Protein differential expression in normal tissues for UCP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UCP3 Gene

SOURCE GeneReport for Unigene cluster for UCP3 Gene Hs.101337

mRNA Expression by UniProt/SwissProt for UCP3 Gene

Tissue specificity: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.
genes like me logo Genes that share expressions with UCP3: view

Expression partners for UCP3 Gene

In Situ Assay Products

Orthologs for UCP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UCP3 35
  • 88.75 (n)
  • 87.46 (a)
UCP3 36
  • 84 (a)
(Canis familiaris)
Mammalia UCP3 35
  • 89.39 (n)
  • 91.96 (a)
(Mus musculus)
Mammalia Ucp3 35
  • 85.28 (n)
  • 86.69 (a)
Ucp3 16
Ucp3 36
  • 87 (a)
(Pan troglodytes)
Mammalia UCP3 35
  • 98.72 (n)
  • 98.4 (a)
UCP3 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ucp3 35
  • 85.82 (n)
  • 87.34 (a)
(Monodelphis domestica)
Mammalia UCP3 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia UCP3 36
  • 80 (a)
(Gallus gallus)
Aves UCP3 35
  • 71.68 (n)
  • 72.88 (a)
UCP3 36
  • 72 (a)
(Anolis carolinensis)
Reptilia UCP3 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ucp1 35
  • 69.9 (n)
  • 75.25 (a)
(Danio rerio)
Actinopterygii ucp1 35
  • 70.46 (n)
  • 72.91 (a)
zgc55824 35
ucp3 36
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 36
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UCP2 35
  • 50.46 (n)
  • 46.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10779 36
  • 37 (a)
Species with no ortholog for UCP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCP3 Gene

Gene Tree for UCP3 (if available)
Gene Tree for UCP3 (if available)

Paralogs for UCP3 Gene

Selected SIMAP similar genes for UCP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UCP3: view

Variants for UCP3 Gene

Sequence variations from dbSNP and Humsavar for UCP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15763 -- 74,000,432(-) CCACG(C/T)GCTCA utr-variant-3-prime
rs632437 -- 73,999,982(+) TCAGA(C/G)CTACG downstream-variant-500B
rs647126 -- 74,000,975(+) GTGGC(A/G)TCCCT utr-variant-3-prime
rs669305 -- 73,999,982(-) GCGTA(C/G)GTCTG downstream-variant-500B
rs826078 -- 74,010,400(+) gggag(A/G)gaagg upstream-variant-2KB

Relevant External Links for UCP3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UCP3 Gene

Disorders for UCP3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for UCP3 Gene in MalaCards »

(3) Diseases for UCP3 Gene including...

(1) OMIM Diseases for UCP3 Gene (602044)


  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:9769326, ECO:0000269 Ref.9}. Note=The gene represented in this entry may be involved in disease pathogenesis.

(1) University of Copenhagen DISEASES for UCP3 Gene

(16) Novoseek inferred disease relationships for UCP3 Gene

Disease -log(P) Hits PubMed IDs
obesity 70.2 87
insulin sensitivity 49.3 10
insulin resistance 45.2 12
niddm 39.7 13
hyperinsulinemia 32.7 3

Relevant External Links for UCP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UCP3: view

No data available for Genatlas for UCP3 Gene

Publications for UCP3 Gene

  1. The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. (PMID: 9325252) Solanes G. … Lowell B.B. (J. Biol. Chem. 1997) 3 4 23
  2. Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity. (PMID: 9498661) Urhammer S.A. … Pedersen O. (Diabetologia 1998) 3 4 23
  3. The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents. (PMID: 10958796) Esterbauer H. … Patsch W. (J. Biol. Chem. 2000) 3 4 23
  4. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. (PMID: 9769326) Argyropoulos G. … Garvey W.T. (J. Clin. Invest. 1998) 3 4 23
  5. An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort. (PMID: 11126413) Meirhaeghe A. … Vasseur F. (Diabetologia 2000) 3 23 48

Products for UCP3 Gene

Sources for UCP3 Gene

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