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Aliases for UCP3 Gene

Aliases for UCP3 Gene

  • Uncoupling Protein 3 2 3
  • Uncoupling Protein 3 (Mitochondrial, Proton Carrier) 2 3 5
  • Solute Carrier Family 25 Member 9 3 4
  • SLC25A9 3 4
  • UCP 3 4

External Ids for UCP3 Gene

Previous GeneCards Identifiers for UCP3 Gene

  • GC11M076038
  • GC11M075251
  • GC11M073934
  • GC11M073437
  • GC11M073388
  • GC11M073711
  • GC11M070007

Summaries for UCP3 Gene

Entrez Gene Summary for UCP3 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

GeneCards Summary for UCP3 Gene

UCP3 (Uncoupling Protein 3) is a Protein Coding gene. Diseases associated with UCP3 include Obesity and Obesity, Ucp3-Related. Among its related pathways are Glucose / Energy Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include transporter activity and oxidative phosphorylation uncoupler activity. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for UCP3 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.

Gene Wiki entry for UCP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP3 Gene

Genomics for UCP3 Gene

Regulatory Elements for UCP3 Gene

Enhancers for UCP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UCP3 on UCSC Golden Path with GeneCards custom track

Promoters for UCP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UCP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for UCP3 Gene

74,000,281 bp from pter
74,009,435 bp from pter
9,155 bases
Minus strand

Genomic View for UCP3 Gene

Genes around UCP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCP3 Gene

Proteins for UCP3 Gene

  • Protein details for UCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial uncoupling protein 3
    Protein Accession:
    Secondary Accessions:
    • O60475
    • Q96HL3

    Protein attributes for UCP3 Gene

    312 amino acids
    Molecular mass:
    34216 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC51785.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UCP3 Gene


neXtProt entry for UCP3 Gene

Proteomics data for UCP3 Gene at MOPED

Post-translational modifications for UCP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCP3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UCP3 (UCP3)
  • Abcam antibodies for UCP3

No data available for DME Specific Peptides for UCP3 Gene

Domains & Families for UCP3 Gene

Gene Families for UCP3 Gene

Suggested Antigen Peptide Sequences for UCP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with UCP3: view

Function for UCP3 Gene

Molecular function for UCP3 Gene

GENATLAS Biochemistry:
uncoupling protein of inner mitochondrial membrane 3,with two forms,long and short missing C terminal 37 residues,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in skeletal muscle during development,regulated by nutritional factors,possible mediator of adaptive thermogenesis,involved in the variation of energy metabolism and obesity,regulated by PPARA and PPARG in mice,and dysregulated in states of insulin resistance,increased expression in function of obesity and in type 2 diabetes (NIDDM)
UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
genes like me logo Genes that share phenotypes with UCP3: view

Animal Models for UCP3 Gene

MGI Knock Outs for UCP3:

Animal Model Products

miRNA for UCP3 Gene

miRTarBase miRNAs that target UCP3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UCP3 Gene

Localization for UCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCP3 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for UCP3 Gene COMPARTMENTS Subcellular localization image for UCP3 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 2
plasma membrane 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for UCP3 Gene

Pathways & Interactions for UCP3 Gene

genes like me logo Genes that share pathways with UCP3: view

SIGNOR curated interactions for UCP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000303 response to superoxide IEA --
GO:0001666 response to hypoxia IEA --
GO:0006412 translation IBA --
GO:0006629 lipid metabolic process TAS 10935638
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with UCP3: view

Drugs & Compounds for UCP3 Gene

(21) Drugs for UCP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(21) Additional Compounds for UCP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UCP3: view

Transcripts for UCP3 Gene

Unigene Clusters for UCP3 Gene

Uncoupling protein 3 (mitochondrial, proton carrier):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCP3 Gene

No ASD Table

Relevant External Links for UCP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCP3 Gene

mRNA expression in normal human tissues for UCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCP3 Gene

This gene is overexpressed in Muscle - Skeletal (x40.9).

Protein differential expression in normal tissues from HIPED for UCP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCP3 Gene

SOURCE GeneReport for Unigene cluster for UCP3 Gene Hs.101337

mRNA Expression by UniProt/SwissProt for UCP3 Gene

Tissue specificity: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.
genes like me logo Genes that share expression patterns with UCP3: view

Protein tissue co-expression partners for UCP3 Gene

Primer Products

Orthologs for UCP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UCP3 35
  • 88.75 (n)
  • 87.46 (a)
UCP3 36
  • 84 (a)
(Canis familiaris)
Mammalia UCP3 35
  • 89.39 (n)
  • 91.96 (a)
(Mus musculus)
Mammalia Ucp3 35
  • 85.28 (n)
  • 86.69 (a)
Ucp3 16
Ucp3 36
  • 87 (a)
(Pan troglodytes)
Mammalia UCP3 35
  • 98.72 (n)
  • 98.4 (a)
UCP3 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ucp3 35
  • 85.82 (n)
  • 87.34 (a)
(Monodelphis domestica)
Mammalia UCP3 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia UCP3 36
  • 80 (a)
(Gallus gallus)
Aves UCP3 35
  • 71.68 (n)
  • 72.88 (a)
UCP3 36
  • 72 (a)
(Anolis carolinensis)
Reptilia UCP3 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ucp1 35
  • 69.9 (n)
  • 75.25 (a)
(Danio rerio)
Actinopterygii ucp1 35
  • 70.46 (n)
  • 72.91 (a)
zgc55824 35
ucp3 36
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 36
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UCP2 35
  • 50.46 (n)
  • 46.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10779 36
  • 37 (a)
Species with no ortholog for UCP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCP3 Gene

Gene Tree for UCP3 (if available)
Gene Tree for UCP3 (if available)

Paralogs for UCP3 Gene

(9) SIMAP similar genes for UCP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UCP3: view

Variants for UCP3 Gene

Sequence variations from dbSNP and Humsavar for UCP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_004407 -
VAR_004408 Obesity (OBESITY)
VAR_050136 -

Variation tolerance for UCP3 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCP3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UCP3 Gene

Disorders for UCP3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for UCP3 Gene - From: OMIM, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • obesity, association with
obesity, ucp3-related
combat disorder
  • combat neurosis
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards
Search UCP3 in MalaCards View complete list of genes associated with diseases


  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:9769326, ECO:0000269 Ref.9}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Relevant External Links for UCP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UCP3: view

No data available for Genatlas for UCP3 Gene

Publications for UCP3 Gene

  1. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. (PMID: 9196039) Vidal-Puig A. … Lowell B.B. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 67
  2. Effects of UCP3 genotype, temperature and muscle type on energy turnover of resting mouse skeletal muscle. (PMID: 18648851) Barclay C.J. … Curtin N.A. (Pflugers Arch. 2009) 3 23
  3. Splicing factor ASF/SF2 and transcription factor PPAR-gamma cooperate to directly regulate transcription of uncoupling protein-3. (PMID: 19073146) Kim D.J. … Kim Y.Y. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men. (PMID: 19155787) Matsunaga T. … Nishiyama T. (J. Hypertens. 2009) 3 23
  5. Transcription of the human uncoupling protein 3 gene is governed by a complex interplay between the promoter and intronic sequences. (PMID: 19468707) Girousse A. … Langin D. (Diabetologia 2009) 3 23

Products for UCP3 Gene

Sources for UCP3 Gene