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UCP3 Gene

protein-coding   GIFtS: 60
GCID: GC11M073711

Uncoupling Protein 3 (Mitochondrial, Proton Carrier)

  See UCP3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Uncoupling Protein 3 (Mitochondrial, Proton Carrier)1 2
Solute Carrier Family 25 Member 92 3
SLC25A92 3
Mitochondrial Uncoupling Protein 32
UCP 33

External Ids:    HGNC: 125191   Entrez Gene: 73522   Ensembl: ENSG000001755647   OMIM: 6020445   UniProtKB: P559163   

Export aliases for UCP3 gene to outside databases

Previous GC identifers: GC11M076038 GC11M075251 GC11M073934 GC11M073437 GC11M073388 GC11M070007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UCP3 Gene:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins
(MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred
to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer
mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane.
They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific
expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to
protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty
acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids
from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants
have been found for this gene.(provided by RefSeq, Nov 2008)

GeneCards Summary for UCP3 Gene:
UCP3 (uncoupling protein 3 (mitochondrial, proton carrier)) is a protein-coding gene. Diseases associated with UCP3 include obesity, ucp3-related, and obesity, severe, and type ii diabetes. GO annotations related to this gene include oxidative phosphorylation uncoupler activity and transporter activity. An important paralog of this gene is UCP1.

UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May
play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance

Gene Wiki entry for UCP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UCP3 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCP3 promoter sequence
   Search Chromatin IP Primers for UCP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

UCP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCP3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073711:  view genomic region     (about GC identifiers)

Start:
73,711,326 bp from pter      End:
73,720,480 bp from pter
Size:
9,155 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916 (See protein sequence)
Recommended Name: Mitochondrial uncoupling protein 3  
Size: 312 amino acids; 34216 Da
Sequence caution: Sequence=AAC51785.1; Type=Erroneous initiation;
Secondary accessions: O60475 Q96HL3
Alternative splicing: 3 isoforms:  P55916-1   P55916-2   P55916-3   

Explore the universe of human proteins at neXtProt for UCP3: NX_P55916

Explore proteomics data for UCP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UCP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003347.1  NP_073714.1  

    ENSEMBL proteins: 
     ENSP00000323740   ENSP00000392143   ENSP00000445279   ENSP00000343615  
    Reactome Protein details: P55916

    UCP3 Human Recombinant Protein Products:

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    Novus Biologicals UCP3 Protein
    Novus Biologicals UCP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UCP3

     
    Search eBioscience for Proteins for UCP3 

     
    antibodies-online proteins for UCP3 (3 products) 

     
    antibodies-online peptides for UCP3

    UCP3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UCP3
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    antibodies-online antibodies for UCP3 (39 products) 

    UCP3 Assay Products:

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    Cloud-Clone Corp. ELISAs for UCP3
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    antibodies-online kits for UCP3 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Uncoupling protein 3
    Mitochondrial uncoupling proteins

    3 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR002030 Mit_uncoupling
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry P55916

    ProtoNet protein and cluster: P55916

    1 Blocks protein domain: IPB002030 Mitochondrial brown fat uncoupling protein signature

    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    Find genes that share domains with UCP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCP3_HUMAN, P55916
    Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
    membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May
    play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance

         Genatlas biochemistry entry for UCP3:
    uncoupling protein of inner mitochondrial membrane 3,with two forms,long and short missing C terminal 37
    residues,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP
    conversion,highly expressed in skeletal muscle during development,regulated by nutritional factors,possible
    mediator of adaptive thermogenesis,involved in the variation of energy metabolism and obesity,regulated by PPARA
    and PPARG in mice,and dysregulated in states of insulin resistance,increased expression in function of obesity
    and in type 2 diabetes (NIDDM)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9196039
    GO:0005515protein binding IPI--
    GO:0017077oxidative phosphorylation uncoupler activity IEA--
         
    Find genes that share ontologies with UCP3           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ucp3):
     adipose tissue  cellular  growth/size/body  homeostasis/metabolism 

    Find genes that share phenotypes with UCP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for UCP3: Ucp3tm1Rei Ucp3tm1Brnd Ucp3tm1Lowl

       genOway: Develop your customized and physiologically relevant rodent model for UCP3

    miRNA
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    miRTarBase miRNAs that target UCP3:
    hsa-mir-342-5p (MIRT038202)

    Block miRNA regulation of human, mouse, rat UCP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UCP3 (see all 40):
    hsa-miR-3607-3p hsa-miR-3655 hsa-miR-330-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-650 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidUCP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UCP3
    Predesigned siRNA for gene silencing in human, mouse, rat UCP3

    Gene Editing
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UCP3_HUMAN, P55916: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    peroxisome2
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS9180264
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane ----

    Find genes that share ontologies with UCP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UCP3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Electron Transport Chain0.75
    2The fatty acid cycling model
    The fatty acid cycling model
    Mitochondrial Uncoupling Proteins0.00
    The proton buffering model0.00
    3Metabolism
    Metabolism0.38
    4Selected targets of GCR alpha
    Selected targets of GCR alpha
    5Selected targets of C EBPbeta
    Selected targets of C EBPbeta


    Find genes that share SuperPaths with UCP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for UCP3
        Diurnally regulated genes with circadian orthologs
    Electron Transport Chain
    Energy Metabolism

    2 Reactome Pathways for UCP3
        The proton buffering model
    The fatty acid cycling model


        Pathway & Disease-focused RT2 Profiler PCR Arrays including UCP3: 
              Mitochondrial Energy Metabolism in human mouse rat
              Mitochondria in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UCP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for UCP3 (P559163 ENSP000003237404) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463, ENSP000003001614I2D: score=3 STRING: ENSP00000300161
    YWHAGP619813, ENSP000003063304I2D: score=2 STRING: ENSP00000306330
    YWHAQP273483, ENSP000002380814I2D: score=4 STRING: ENSP00000238081
    YWHAZP631043, ENSP000003095034I2D: score=4 STRING: ENSP00000309503
    NCOR1ENSP000002687124STRING: ENSP00000268712
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000303response to superoxide IEA--
    GO:0001666response to hypoxia IEA--
    GO:0006629lipid metabolic process TAS10935638
    GO:0006631fatty acid metabolic process IEA--
    GO:0006839mitochondrial transport IEA--

    Find genes that share ontologies with UCP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UCP3

    Selected Novoseek inferred chemical compound relationships for UCP3 gene (see all 42)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 71.3 114 14525936 (5), 15294045 (5), 14671191 (4), 15814607 (4) (see all 45)
    etomoxir 64 6 11470240 (2), 11511517 (1), 16306367 (1), 12206997 (1)
    carnitine 54.5 13 16092055 (2), 12540388 (1), 19448714 (1), 14761878 (1) (see all 9)
    atp 54.5 35 11511517 (2), 17030788 (2), 15024403 (1), 9769326 (1) (see all 22)
    glucose 49.5 75 11278970 (6), 18167556 (5), 11511517 (4), 19283340 (3) (see all 34)
    carbacyclin 48.8 1 10567719 (1)
    hydrogen 47.9 24 12145158 (4), 11707458 (2), 18059613 (2), 16005426 (1) (see all 13)
    pyruvate 46.6 14 16092055 (2), 19448714 (1), 14761878 (1), 15932964 (1) (see all 9)
    oxygen 46 21 16968671 (3), 16046300 (2), 16005426 (1), 17303124 (1) (see all 13)
    acipimox 44.7 1 17186295 (1)



    Find genes that share compounds with UCP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UCP3 gene (2 alternative transcripts): 
    NM_003356.3  NM_022803.2  

    Unigene Cluster for UCP3:

    Uncoupling protein 3 (mitochondrial, proton carrier)
    Hs.101337  [show with all ESTs]
    Unigene Representative Sequence: NM_003356
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314032(uc001our.3) ENST00000545271 ENST00000426995(uc001ous.2)
    ENST00000544614 ENST00000348534
    miRNA
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    hsa-miR-3607-3p hsa-miR-3655 hsa-miR-330-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-650 hsa-miR-877*
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      QuantiTect SYBR Green Assays in human, mouse, rat UCP3
      QuantiFast Probe-based Assays in human, mouse, rat UCP3

    Additional mRNA sequence: 

    AF001787.1 AF011449.1 AK092685.1 AK290630.1 AK291889.1 AK309873.1 BC008392.1 U82818.1 
    U84763.1 

    6 DOTS entries:

    DT.100736825  DT.208463  DT.99927646  DT.40252962  DT.120718117  DT.97763855 

    Selected AceView cDNA sequences (see all 38):

    U82818 NM_022803 AW295096 BU739937 AF001787 U84763 AA192136 BQ446444 
    NM_003356 AI670961 BU618868 BC008392 CD616918 AA779805 BF507985 AK092685 
    Z28895 Z25295 BM715026 AF011449 BG236319 C14769 AW439483 AW589767 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UCP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTACCTCAA
    UCP3 Expression
    About this image


    UCP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
    UCP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UCP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.101337

    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
    Tissue specificity: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal
    muscles

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UCP3: 
              Mitochondrial Energy Metabolism in human mouse rat
              Mitochondria in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for UCP3
    OriGene qSTAR qPCR primer pairs in human, mouse for UCP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCP3
    QuantiTect SYBR Green Assays in human, mouse, rat UCP3
    QuantiFast Probe-based Assays in human, mouse, rat UCP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UCP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ucp31 , 5 uncoupling protein 3 (mitochondrial, proton carrier)1, 5 85.28(n)1
    86.69(a)1
      7 (54.36 cM)5
    222291  NM_009464.31  NP_033490.11 
     1004729905 
    chicken
    (Gallus gallus)
    Aves UCP31 uncoupling protein 3 (mitochondrial, proton carrier) 71.68(n)
    72.88(a)
      373896  NM_204107.1  NP_989438.1 
    lizard
    (Anolis carolinensis)
    Reptilia UCP36
    uncoupling protein 3 (mitochondrial, proton carrie...
    77(a)
    1 ↔ 1
    GL343978.1(51675-84185)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ucp11 uncoupling protein 1 (mitochondrial, proton carrier) 69.9(n)
    75.25(a)
      100135179  NM_001113882.1  NP_001107354.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558242 similar to uncoupling protein 3 (mitochondrial, proton more 78.45(n)   394186  AY398428.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIC16
    Mitochondrial dicarboxylate carrier, integral memb...
    31(a)
    1 → many
    XII(826977-827873) YLR348C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UCP21 UCP2 50.46(n)
    46.23(a)
      836014  NM_125287.4  NP_568894.1 


    ENSEMBL Gene Tree for UCP3 (if available)
    TreeFam Gene Tree for UCP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UCP3 gene
    UCP12  UCP22  SLC25A142  SLC25A112  ENSG000002626602  SLC25A102  SLC25A302  SLC25A272  
    9 SIMAP similar genes for UCP3 using alignment to 3 protein entries:     UCP3_HUMAN (see all proteins):
    UCP2    SLC25A14    UCP1    SLC25A30    SLC25A11    SLC25A10
    SLC25A34    SLC25A27    SLC25A19

    Find genes that share paralogs with UCP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UCP3 (see all 334)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22297071,2,,4
    C,F,HObesity (OBESITY)4 pathogenic173582870(-) ACTCCG/ATCAAG 4 /I /V mis1 ese313Minor allele frequency- A:0.04MN NS EA NA WA CSA EU 6422
    rs1048943191,2
    C,Fpathogenic173582512(-) AGGTCC/TGATTT 4 R * stg12Minor allele frequency- T:0.00NA EU 5875
    rs178483681,2,,4
    Cpathogenic173582966(-) TGGTGC/TGGACT 4 R W mis1 ese32Minor allele frequency- T:0.00NA 4
    rs79304601,2
    C,F,H--73576507(+) GGTCAA/GCCCTC 1 -- int128Minor allele frequency- G:0.23EA NA NS WA 2982
    rs1380252191,2
    --73576566(+) ACACCA/GAGGTG 1 -- int10--------
    rs1435196261,2
    --73576584(+) TCCCTA/GTGGCT 1 -- int10--------
    rs802011511,2
    F--73576639(+) TGACAA/CTCATC 1 -- int10--------
    rs6324371,2
    C,H--73576648(+) TCAGAG/CCTACG 1 -- int15Minor allele frequency- C:0.00MN NS EA 594
    rs1386386651,2
    --73576653(+) GCTACA/GCAAGG 1 -- int10--------
    rs1492351681,2
    --73576680(+) AAAGAC/TAGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for UCP3 (73711326 - 73720480 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UCP3: --
    Human Gene Mutation Database (HGMD): UCP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UCP3
    DNA2.0 Custom Variant and Variant Library Synthesis for UCP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602044   
    OMIM disorders: 601665  
    UniProtKB/Swiss-Prot: UCP3_HUMAN, P55916
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the
    limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=The
    gene represented in this entry may be involved in disease pathogenesis

  • 15 diseases for UCP3:    
    About MalaCards
    obesity, ucp3-related    obesity, severe, and type ii diabetes    retinitis pigmentosa 23    obesity, autosomal dominant
    obesity, late-onset    morbid obesity    obesity, early-onset    obesity, association with
    obesity, variation in    obesity, mild, early-onset    pulmonary disease, chronic obstructive    obesity
    insulin resistance    type 2 diabetes mellitus    amyotrophic lateral sclerosis

    1 disease from the University of Copenhagen DISEASES database for UCP3:
    Diabetes mellitus

    Find genes that share disorders with UCP3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for UCP3 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 70.2 99 11319649 (3), 16006788 (3), 18059082 (3), 17598332 (3) (see all 61)
    insulin sensitivity 49.3 11 12153598 (2), 18059082 (2), 19468707 (1), 10403804 (1) (see all 8)
    insulin resistance 45.2 13 16046300 (3), 19913848 (1), 17828388 (1), 18220632 (1) (see all 10)
    niddm 39.7 13 9726246 (5), 17150099 (1), 11151767 (1), 11484071 (1) (see all 9)
    hyperinsulinemia 32.7 4 19875988 (1), 9511737 (1), 10615946 (1)
    metabolic disorder 32.3 4 10395193 (1), 11080246 (1), 10618503 (1), 11237725 (1)
    impaired glucose tolerance 23.5 5 17587402 (1), 19769793 (1), 19782153 (1), 16384852 (1)
    hyperlipidemia 7.16 1 10868951 (1)
    cancer 0.781 2 16337086 (1), 15334872 (1)
    tumors 0.772 4 11278795 (1), 10868951 (1), 19680556 (1), 16741147 (1)

    Genetic Association Database (GAD): UCP3
    Human Genome Epidemiology (HuGE) Navigator: UCP3 (83 documents)

    Export disorders for UCP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UCP3 gene, integrated from 10 sources (see all 391):
    (articles sorted by number of sources associating them with UCP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. (PubMed id 9196039)1, 2, 3, 9 Vidal-Puig A.... Lowell B.B. (Biochem. Biophys. Res. Commun. 1997)
    2. Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men. (PubMed id 19155787)1, 4, 9 Matsunaga T....Nishiyama T. (J. Hypertens. 2009)
    3. Modulation of adipocytokines response and weight loss secondary to a hypocaloric diet in obese patients by -55CT polymorphism of UCP3 gene. (PubMed id 18348082)1, 4, 9 de Luis D.A....Conde R. (Horm. Metab. Res. 2008)
    4. Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes. (PubMed id 18426825)1, 4, 9 van Abeelen A.F....van der Schouw Y.T. (Eur. J. Endocrinol. 2008)
    5. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. (PubMed id 16373902)1, 4, 9 Rudofsky G....Hamann A. (Diabetes Care 2006)
    6. The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. (PubMed id 9325252)1, 2, 9 Solanes G.... Lowell B.B. (J. Biol. Chem. 1997)
    7. Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women. (PubMed id 17512314)1, 4, 9 Cha M.H....Yoon Y. (Metab. Clin. Exp. 2007)
    8. Association of UCP3 gene -55C&gt;T polymorphism and obesity in a Spanish population. (PubMed id 16006788)1, 4, 9 Alonso A....MartA-nez J.A. (amp 2005)
    9. Association between uncoupling protein 3 gene and obesity-related phenotypes in the QuAcbec Family Study. (PubMed id 11683368)1, 4, 9 Lanouette C.M....Chagnon Y.C. (Mol. Med. 2001)
    10. Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population. (PubMed id 11319649)1, 4, 9 Halsall D.J....O'Rahilly S. (Int. J. Obes. Relat. Metab. Disord. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7352 HGNC: 12519 AceView: UCP3 Ensembl:ENSG00000175564 euGenes: HUgn7352
    ECgene: UCP3 H-InvDB: UCP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UCP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UCP3 gene:
    Search GeneIP for patents involving UCP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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