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Aliases for UCP2 Gene

Aliases for UCP2 Gene

  • Uncoupling Protein 2 (Mitochondrial, Proton Carrier) 2 3
  • Solute Carrier Family 25 Member 8 3 4
  • SLC25A8 3 4
  • BMIQ4 3 6
  • UCPH 3 4
  • Body Mass Index Quantitative Trait 4 2
  • Mitochondrial Uncoupling Protein 2 3
  • Body Mass Index QTL 4 2
  • UCP 2 4

External Ids for UCP2 Gene

Previous HGNC Symbols for UCP2 Gene

  • BMIQ4

Previous GeneCards Identifiers for UCP2 Gene

  • GC11M076013
  • GC11M075225
  • GC11M073909
  • GC11M073412
  • GC11M073363
  • GC11M073685
  • GC11M069981

Summaries for UCP2 Gene

Entrez Gene Summary for UCP2 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCP2 Gene

UCP2 (Uncoupling Protein 2 (Mitochondrial, Proton Carrier)) is a Protein Coding gene. Diseases associated with UCP2 include obesity bmiq4 and hyperinsulinism due to ucp2 deficiency. Among its related pathways are Metabolism and FOXA2 and FOXA3 transcription factor networks. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for UCP2 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Gene Wiki entry for UCP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP2 Gene

Genomics for UCP2 Gene

Regulatory Elements for UCP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UCP2 Gene

Start:
73,974,667 bp from pter
End:
73,983,307 bp from pter
Size:
8,641 bases
Orientation:
Minus strand

Genomic View for UCP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCP2 Gene

Proteins for UCP2 Gene

  • Protein details for UCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55851-UCP2_HUMAN
    Recommended name:
    Mitochondrial uncoupling protein 2
    Protein Accession:
    P55851
    Secondary Accessions:
    • Q4PJH8
    • Q53HM3

    Protein attributes for UCP2 Gene

    Size:
    309 amino acids
    Molecular mass:
    33229 Da
    Quaternary structure:
    • Acts as a dimer forming a proton channel.

neXtProt entry for UCP2 Gene

Proteomics data for UCP2 Gene at MOPED

Post-translational modifications for UCP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UCP2 Gene

Domains for UCP2 Gene

Gene Families for UCP2 Gene

Suggested Antigen Peptide Sequences for UCP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55851

UniProtKB/Swiss-Prot:

UCP2_HUMAN :
  • P55851
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with UCP2: view

Function for UCP2 Gene

Molecular function for UCP2 Gene

GENATLAS Biochemistry: uncoupling protein of inner mitochondrial membrane 2,highly homolog to UCP1 and UCP3,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in adipose tissue and muscle,involved in the variation of energy metabolism with a reduced expression in skeletal muscle and intraperitoneal tissue (reduced gene expression in skeletal muscle of obese),regulated by PPARA and PPARG in mice
UniProtKB/Swiss-Prot Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Gene Ontology (GO) - Molecular Function for UCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UCP2: view
genes like me logo Genes that share phenotypes with UCP2: view

Animal Models for UCP2 Gene

MGI Knock Outs for UCP2:

Animal Model Products

CRISPR Products

miRNA for UCP2 Gene

miRTarBase miRNAs that target UCP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for UCP2 Gene

Localization for UCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCP2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCP2 Gene COMPARTMENTS Subcellular localization image for UCP2 gene
Compartment Confidence
mitochondrion 5
nucleus 2
peroxisome 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane --
genes like me logo Genes that share ontologies with UCP2: view

Pathways for UCP2 Gene

genes like me logo Genes that share pathways with UCP2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for UCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000303 response to superoxide IEA --
GO:0001666 response to hypoxia IDA 22292025
GO:0006810 transport NAS 9196039
GO:0006839 mitochondrial transport IEA --
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with UCP2: view

Compounds for UCP2 Gene

(69) Novoseek inferred chemical compound relationships for UCP2 Gene

Compound -log(P) Hits PubMed IDs
atp 67.7 54
fatty acid 66.8 41
glucose 59 74
oxygen 57.2 66
rosiglitazone 52.1 7
genes like me logo Genes that share compounds with UCP2: view

Transcripts for UCP2 Gene

Unigene Clusters for UCP2 Gene

Uncoupling protein 2 (mitochondrial, proton carrier):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
SP1: - - - - - - -
SP2: -
SP3:
SP4: - - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - - -

Relevant External Links for UCP2 Gene

GeneLoc Exon Structure for
UCP2
ECgene alternative splicing isoforms for
UCP2

Expression for UCP2 Gene

mRNA expression in normal human tissues for UCP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCP2 Gene

This gene is overexpressed in Whole Blood (14.7) and Spleen (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UCP2 Gene

SOURCE GeneReport for Unigene cluster for UCP2 Gene Hs.80658

mRNA Expression by UniProt/SwissProt for UCP2 Gene

P55851-UCP2_HUMAN
Tissue specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle
genes like me logo Genes that share expressions with UCP2: view

In Situ Assay Products

Orthologs for UCP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCP2 35
  • 99.68 (n)
  • 99.35 (a)
UCP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UCP2 35
  • 90.4 (n)
  • 95.47 (a)
UCP2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCP2 35
  • 92.34 (n)
  • 97.41 (a)
UCP2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ucp2 35
  • 89.97 (n)
  • 96.12 (a)
Ucp2 16
Ucp2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UCP2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCP2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ucp2 35
  • 88.67 (n)
  • 95.47 (a)
lizard
(Anolis carolinensis)
Reptilia UCP2 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ucp2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75881 35
ucp2 35
  • 74.48 (n)
  • 82.74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8891 35
zebrafish
(Danio rerio)
Actinopterygii ucp2 35
ucp2 35
  • 73.6 (n)
  • 84.16 (a)
ucp2 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011676 35
  • 61.81 (n)
  • 62.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dic2 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PUMP1 35
  • 53.9 (n)
  • 52.79 (a)
rice
(Oryza sativa)
Liliopsida Os11g0707800 35
  • 56.69 (n)
  • 50.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10779 36
  • 37 (a)
OneToMany
Species with no ortholog for UCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCP2 Gene

ENSEMBL:
Gene Tree for UCP2 (if available)
TreeFam:
Gene Tree for UCP2 (if available)

Paralogs for UCP2 Gene

genes like me logo Genes that share paralogs with UCP2: view

Variants for UCP2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UCP2 Gene

P55851-UCP2_HUMAN
Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIM:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals

Sequence variations from dbSNP and Humsavar for UCP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs603573 -- 73,980,234(-) CAAAG(A/G)CAGTC intron-variant
rs615561 -- 73,979,832(-) GGTTT(G/T)TTTTT intron-variant
rs632862 -- 73,982,376(-) CTGCT(C/G)AGCTC intron-variant
rs649446 -- 73,984,800(-) gcaca(A/G)tggct upstream-variant-2KB
rs659366 other 73,983,709(+) ACTGA(C/T)GCGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UCP2 Gene

Variant ID Type Subtype PubMed ID
nsv520299 CNV Loss 19592680

Relevant External Links for UCP2 Gene

HapMap Linkage Disequilibrium report
UCP2
Human Gene Mutation Database (HGMD)
UCP2

Disorders for UCP2 Gene

(1) OMIM Diseases for UCP2 Gene (601693)

(2) University of Copenhagen DISEASES for UCP2 Gene

(31) Novoseek inferred disease relationships for UCP2 Gene

Disease -log(P) Hits PubMed IDs
obesity 73.5 155
insulin sensitivity 48.8 10
insulin resistance 46.1 8
hyperinsulinemia 40.7 8
niddm 38.1 12

Relevant External Links for UCP2

Genetic Association Database (GAD)
UCP2
Human Genome Epidemiology (HuGE) Navigator
UCP2
genes like me logo Genes that share disorders with UCP2: view

No data available for UniProtKB/Swiss-Prot for UCP2 Gene

Publications for UCP2 Gene

  1. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. (PMID: 11381268) Esterbauer H. … Patsch W. (Nat. Genet. 2001) 2 3 4 23 48
  2. Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort. (PMID: 12395215) Nieters A. … Linseisen J. (Eur J Nutr 2002) 3 23 48
  3. A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. (PMID: 12401727) Krempler F. … Patsch W. (Diabetes 2002) 3 23 48
  4. A 45-bp insertion/deletion polymorphism of uncoupling protein 2 in relation to obesity in Tongans. (PMID: 12690079) Duarte N.L. … Wilcken D.E. (Obes. Res. 2003) 3 23 48
  5. A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. (PMID: 12716765) Sesti G. … Lauro R. (Diabetes 2003) 3 23 48

Products for UCP2 Gene

Sources for UCP2 Gene

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