Aliases for UCP2 Gene
External Ids for UCP2 Gene
Previous HGNC Symbols for UCP2 Gene
Previous GeneCards Identifiers for UCP2 Gene
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
GeneCards Summary for UCP2 Gene
UCP2 (Uncoupling Protein 2) is a Protein Coding gene. Diseases associated with UCP2 include Obesity Bmiq4 and Hyperinsulinemic Hypoglycemia, Familial, 2. Among its related pathways are The fatty acid cycling model and Transcriptional activation of mitochondrial biogenesis. An important paralog of this gene is UCP3.
UniProtKB/Swiss-Prot for UCP2 Gene
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.