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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCP2 Gene

protein-coding   GIFtS: 66
GCID: GC11M073685

Uncoupling Protein 2 (Mitochondrial, Proton Carrier)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Uncoupling Protein 2 (Mitochondrial, Proton Carrier)1 2     UCP 22 3
Solute Carrier Family 25 Member 82 3     BMIQ42 5
SLC25A82 3     Mitochondrial Uncoupling Protein 22
UCPH2 3     

External Ids:    HGNC: 125181   Entrez Gene: 73512   Ensembl: ENSG000001755677   OMIM: 6016935   UniProtKB: P558513   

Export aliases for UCP2 gene to outside databases

Previous GC identifers: GC11M076013 GC11M075225 GC11M073909 GC11M073412 GC11M073363 GC11M069981


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCP2 Gene:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins
(MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred
to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer
mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane.
They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the
different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous
protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal
muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is
5'-UCP3-UCP2-3'. (provided by RefSeq, Jul 2008)

GeneCards Summary for UCP2 Gene: 
UCP2 (uncoupling protein 2 (mitochondrial, proton carrier)) is a protein-coding gene. Diseases associated with UCP2 include hyperinsulinism due to ucp2 deficiency, and obesity, variation in, and among its related super-pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and The proton buffering model. An important paralog of this gene is UCP3.

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the
form of heat

Gene Wiki entry for UCP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCP2 gene promoter:
         GR   PPAR-alpha   NF-1   RelA   GR-alpha   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13

UCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073685:  view genomic region     (about GC identifiers)

Start:
73,685,712 bp from pter      End:
73,694,352 bp from pter
Size:
8,641 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851 (See protein sequence)
Recommended Name: Mitochondrial uncoupling protein 2  
Size: 309 amino acids; 33229 Da
Subunit: Acts as a dimer forming a proton channel (By similarity)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: Q4PJH8 Q53HM3

Explore the universe of human proteins at neXtProt for UCP2: NX_P55851

Explore proteomics data for UCP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55851

  • UCP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UCP2 Protein Expression
    REFSEQ proteins: NP_003346.2  
    ENSEMBL proteins: 
     ENSP00000312029   ENSP00000441147   ENSP00000439951   ENSP00000439706   ENSP00000438230  
    Reactome Protein details: P55851
    Human Recombinant Protein Products for UCP2: 
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    Novus Biologicals UCP2 Protein
    Novus Biologicals UCP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UCP2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031966mitochondrial membrane ----

    UCP2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for UCP2 
    Cloud-Clone Corp. CLIAs for UCP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Uncoupling protein 2 
    Mitochondrial uncoupling proteins

    3 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR002030 Mit_uncoupling
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry P55851

    ProtoNet protein and cluster: P55851

    1 Blocks protein domain: IPB002030 Mitochondrial brown fat uncoupling protein signature

    UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    UCP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCP2_HUMAN, P55851
    Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
    membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the
    form of heat

         Genatlas biochemistry entry for UCP2:
    uncoupling protein of inner mitochondrial membrane 2,highly homolog to UCP1 and UCP3,dissipating the proton
    electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in adipose tissue
    and muscle,involved in the variation of energy metabolism with a reduced expression in skeletal muscle and
    intraperitoneal tissue (reduced gene expression in skeletal muscle of obese),regulated by PPARA and PPARG in mice

    Phenotypes:
         2 GenomeRNAi human phenotypes for UCP2:
     Decreased viability  Synthetic lethal with imatinib 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ucp2):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  respiratory system 

    UCP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for UCP2: Ucp2tm1Lowl Ucp2tm1Rcq

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UCP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UCP2 

    miRNA
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    miRTarBase miRNAs that target UCP2:
    hsa-mir-15a (MIRT004046)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCP2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate UCP2 (see all 11):
    hsa-miR-4291 hsa-miR-922 hsa-miR-15a hsa-miR-450b-3p hsa-miR-497 hsa-miR-214 hsa-miR-424 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidUCP2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UCP2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Electron Transport Chain0.75
    2The fatty acid cycling model
    Mitochondrial Uncoupling Proteins1.00
    The fatty acid cycling model1.00
    The proton buffering model1.00
    3Metabolism
    Metabolism0.40
    4Selected targets of HNF1
    Selected targets of HNF1
    5FOXA2 and FOXA3 transcription factor networks
    FOXA2 and FOXA3 transcription factor networks

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UCP2
        Selected targets of HNF1


    3 BioSystems Pathways for UCP2
        Electron Transport Chain
    Energy Metabolism
    FOXA2 and FOXA3 transcription factor networks

    5/6        Reactome Pathways for UCP2 (see all 6)
        The proton buffering model
    Mitochondrial Uncoupling Proteins
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport



    UCP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for UCP2 (P558513 ENSP000003120294) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463, ENSP000003001614I2D: score=3 STRING: ENSP00000300161
    YWHAGP619813, ENSP000003063304I2D: score=2 STRING: ENSP00000306330
    YWHAQP273483, ENSP000002380814I2D: score=4 STRING: ENSP00000238081
    YWHAZP631043, ENSP000003095034I2D: score=4 STRING: ENSP00000309503
    FOXA2ENSP000003159554STRING: ENSP00000315955
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000303response to superoxide IEA--
    GO:0001666response to hypoxia IEA--
    GO:0006810transport NAS9196039
    GO:0006839mitochondrial transport IEA--
    GO:0009749response to glucose stimulus IEA--

    UCP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UCP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for UCP2

    Browse Tocris compounds for UCP2

    10/69 Novoseek inferred chemical compound relationships for UCP2 gene (see all 69)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 67.7 87 17131143 (3), 19763737 (2), 20056920 (2), 20030709 (2) (see all 47)
    fatty acid 66.8 50 10868951 (2), 12418549 (2), 17855623 (2), 11061990 (2) (see all 36)
    glucose 59 98 19272350 (4), 17131143 (4), 18167556 (4), 11904148 (3) (see all 46)
    oxygen 57.2 98 18082129 (4), 20056920 (3), 17131143 (3), 15016641 (2) (see all 53)
    rosiglitazone 52.1 7 10849580 (2), 19659999 (2), 10548525 (1), 10066437 (1) (see all 5)
    hydrogen 51.7 39 18308829 (4), 11278935 (2), 14693721 (1), 16005426 (1) (see all 22)
    adp 50.8 12 17131143 (2), 19230380 (1), 11145588 (1), 11171965 (1) (see all 9)
    palmitate 46.4 6 17303124 (1), 11278935 (1), 11701434 (1), 11289045 (1) (see all 5)
    thiazolidinedione 45.9 8 10849580 (3), 10843184 (1), 11056218 (1)
    carbacyclin 43.3 1 12588052 (1)

    Search CenterWatch for drugs/clinical trials and news about UCP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UCP2 gene: 
    NM_003355.2  

    Unigene Cluster for UCP2:

    Uncoupling protein 2 (mitochondrial, proton carrier)
    Hs.80658  [show with all ESTs]
    Unigene Representative Sequence: AK025742
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310473(uc001oup.1) ENST00000536983 ENST00000544615 ENST00000545212
    ENST00000545562 ENST00000543714 ENST00000539764 ENST00000542615 ENST00000541027
    ENST00000539330
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate UCP2 (see all 11):
    hsa-miR-4291 hsa-miR-922 hsa-miR-15a hsa-miR-450b-3p hsa-miR-497 hsa-miR-214 hsa-miR-424 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidUCP2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK025742.1 AK222540.1 AK222557.1 BC011737.2 U76367.1 U82819.1 U94592.1 

    24/25 DOTS entries (see all 25):

    DT.100816705  DT.214741  DT.40117015  DT.120754392  DT.95171778  DT.120754424  DT.120754391  DT.120754427 
    DT.120754440  DT.95117837  DT.100816708  DT.97759938  DT.120754419  DT.120754431  DT.75133198  DT.95171780 
    DT.100816706  DT.100816717  DT.120754436  DT.120754438  DT.86854501  DT.95171793  DT.120754417  DT.91847081 

    24/405 AceView cDNA sequences (see all 405):

    BP335064 CR610551 BQ055250 H61243 BE388233 CR624968 CA311021 U82819 
    BF089839 CB054166 AW328072 CB140117 BM920280 BI769192 AK025742 BC011737 
    CR607497 BP339606 CR625575 AL542338 CR607585 CR608184 NM_003355 AW328073 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UCP2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
    SP1:              -     -     -     -     -                 -     -                                                         
    SP2:              -                                                                                                         
    SP3:                                                                                                                        
    SP4:              -     -     -     -                       -     -                                                         
    SP5:              -     -                                                                                                   


    ECgene alternative splicing isoforms for UCP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCP2 expression in normal human tissues (normalized intensities)      UCP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCCTTTT
    UCP2 Expression
    About this image


    UCP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
             Septum   
     
     Blood (Cardiovascular System)    fully expand to see all 6 entries
             Double Negative 2 Thymocytes Thymus
             Peripheral blood Pan-T Cells   
     
     Nose (Sensory Organs)    fully expand to see all 4 entries
             sensory organ/nose   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
     
     Liver (Hepatobiliary System)
             Fetal Liver CD36+ Cells   

    See UCP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCP2

    SOURCE GeneReport for Unigene cluster: Hs.80658

    UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851
    Tissue specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed
    in white adipose tissue and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including UCP2: 
              Mitochondrial Energy Metabolism in human mouse rat
              Mitochondria in human mouse rat
              Oxidative Stress in human mouse rat
              Diabetes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UCP2 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ucp21 , 5 uncoupling protein 2 (mitochondrial, proton carrier)1, 5 89.97(n)1
    96.12(a)1
      7 (54.36 cM)5
    222281  NM_011671.41  NP_035801.31 
     1004933375 
    lizard
    (Anolis carolinensis)
    Reptilia UCP26
    uncoupling protein 2 (mitochondrial, proton carrie...
    78(a)
    1 ↔ 1
    GL344128.1(56659-65376)
    African clawed frog
    (Xenopus laevis)
    Amphibia ucp2-prov2 uncoupling protein 2 80.07(n)    BC044682.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ucp22 uncoupling protein 2 77.15(n)   30414  BC056737.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0116761 AGAP011676-PA 61.81(n)
    62.5(a)
      1280964  XM_552584.3  XP_552584.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIC16
    Mitochondrial dicarboxylate carrier, integral memb...
    29(a)
    1 → many
    XII(826977-827873)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PUMP11 uncoupling mitochondrial protein 1 53.33(n)
    52(a)
      824578  NM_115271.4  NP_190979.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g07078001 hypothetical protein 56.57(n)
    50.36(a)
      4351228  NM_001075091.1  NP_001068559.2 


    ENSEMBL Gene Tree for UCP2 (if available)
    TreeFam Gene Tree for UCP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UCP2 gene
    UCP32  UCP12  SLC25A142  SLC25A112  ENSG000002626602  SLC25A102  SLC25A302  SLC25A272  
    11 SIMAP similar genes for UCP2 using alignment to 5 protein entries:     UCP2_HUMAN (see all proteins):
    UCP1    UCP3    SLC25A10    SLC25A14    SLC25A30    SLC25A11
    SLC25A34    SLC25A27    SLC25A22    SLC25A47    SLC25A19

    UCP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851
    Polymorphism: Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4)
    [MIM:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk
    of obesity in middle-aged individuals


    10/302 SNPs in UCP2 are shown (see all 302)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105355271,2
    C--69982626(+) CAGGA-/CTTCTTTT 1 -- int10--------
    rs454431021,2
    F--69982627(-) AAAAG-/AAGTCCT 1 -- int15Minor allele frequency- AA:0.41NS 130
    rs1928634701,2
    --73550875(+) TCTCAC/TAAGGT 1 -- ds50010--------
    rs455200371,2
    C,F--73550892(-) CTCCCC/GCAAAG 1 -- ds50016Minor allele frequency- G:0.04NS WA 292
    rs456263321,2
    C,F--73551098(-) TTTGCC/TGGGCC 1 -- ds50015Minor allele frequency- T:0.03NS 174
    rs118237671,2
    C,F,H--73551110(+) GAAGGG/TGAGGC 1 -- ds50018Minor allele frequency- T:0.04NS WA NA 300
    rs1850583171,2
    --73551145(+) GCACTC/TCCCAT 1 -- ds50010--------
    rs455833311,2
    C,F--73551199(-) AGCCCG/CTGTAG 1 -- ds50016Minor allele frequency- C:0.04NS WA 304
    rs455232361,2
    C,F--73551261(-) GAGGAA/CCCACC 1 -- ds50016Minor allele frequency- C:0.02NS WA 306
    rs1433666711,2
    --73551304(+) ACCAAC/GACCTC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for UCP2 (73685712 - 73694352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UCP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520299CNV Loss19592680


    Human Gene Mutation Database (HGMD): UCP2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601693   
    OMIM disorders: 607447  
    20/67 diseases for UCP2 (see all 67):    About MalaCards
    hyperinsulinism due to ucp2 deficiency    obesity, variation in    obstructive jaundice    ascariasis
    morbid obesity    obesity    trichuriasis    neural tube defects
    obesity, association with    diabetic neuropathy    fatty liver disease    insulinoma
    hyperinsulinism    jaundice    liver disease    glucose intolerance
    cerebrovascular disease    hyperhomocysteinemia    sleep apnea    obsessive-compulsive disorder

    2 diseases from the University of Copenhagen DISEASES database for UCP2:
    Diabetes mellitus     Hyperglycemia

    UCP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/31 Novoseek inferred disease relationships for UCP2 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 73.5 195 15165610 (6), 19950601 (5), 10102249 (5), 15061987 (4) (see all 89)
    insulin sensitivity 48.8 11 9837864 (2), 12153598 (2), 18059082 (2), 16477380 (1) (see all 7)
    insulin resistance 46.1 9 15220218 (2), 19272350 (1), 19556617 (1), 17397545 (1) (see all 7)
    hyperinsulinemia 40.7 9 14717811 (1), 12588051 (1), 19908126 (1), 10605819 (1) (see all 8)
    niddm 38.1 16 9709950 (2), 17916951 (2), 9726246 (2), 9349606 (1) (see all 9)
    metabolic disorder 34.6 4 10395193 (1), 12743644 (1), 11080246 (1)
    insulinoma 32.5 4 18692019 (2), 11145588 (1), 20206170 (1)
    fatty liver 28.2 4 15970480 (2), 15387925 (1), 18846338 (1)
    impaired glucose tolerance 27.3 3 19769793 (1), 10382588 (1)
    hyperglycemia 23.7 9 19556617 (3), 14679178 (2), 18290312 (2), 18167556 (1) (see all 5)

    Genetic Association Database (GAD): UCP2
    Human Genome Epidemiology (HuGE) Navigator: UCP2 (134 documents)

    Export disorders for UCP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCP2 gene, integrated from 9 sources (see all 590):
    (articles sorted by number of sources associating them with UCP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. (PubMed id 11381268)1, 2, 4, 9 Esterbauer H.... Patsch W. (2001)
    2. [Study on polymorphism of UCP2 gene in Chengdu simple obesity and normal-weight people and a preliminary investigation of its relati onship with gut bacteria] (PubMed id 19950601)1, 4, 9 Zuo H.J....Pei X.F. (2009)
    3. Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men. (PubMed id 19155787)1, 4, 9 Matsunaga T....Nishiyama T. (2009)
    4. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. (PubMed id 16373902)1, 4, 9 Rudofsky G....Hamann A. (2006)
    5. Is UCP2 gene polymorphism associated with decreased resting energy expenditure in nondialyzed chronic kidney disease patients? (PubMed id 18940651)1, 4, 9 Avesani C.M....Cuppari L. (2008)
    6. Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk? (PubMed id 18839467)1, 4, 9 Heill S.G....Blom H.J. (2008)
    7. Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis. (PubMed id 16021520)1, 4, 9 Vogler S....Ibrahim S.M. (2005)
    8. Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians. (PubMed id 16167150)1, 4, 9 Kovacs P....Baier L.J. (2005)
    9. Simple and rapid detection of uncoupling protein-2 - 866G/A polymorphism by mutagenically separated polymerase chain reaction. (PubMed id 15149891)1, 4, 9 Zhang B....Saku K. (2004)
    10. Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. (PubMed id 12915397)1, 4, 9 Wang H....Elbein S.C. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7351 HGNC: 12518 AceView: UCP2 Ensembl:ENSG00000175567 euGenes: HUgn7351
    ECgene: UCP2 H-InvDB: UCP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCP2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ucp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UCP2 gene:
    Search GeneIP for patents involving UCP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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