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Aliases for UCP2 Gene

Aliases for UCP2 Gene

  • Uncoupling Protein 2 2 3
  • Uncoupling Protein 2 (Mitochondrial, Proton Carrier) 2 3 5
  • Solute Carrier Family 25 Member 8 3 4
  • SLC25A8 3 4
  • UCPH 3 4
  • Body Mass Index Quantitative Trait 4 2
  • Body Mass Index QTL 4 2
  • BMIQ4 3
  • UCP 2 4

External Ids for UCP2 Gene

Previous HGNC Symbols for UCP2 Gene

  • BMIQ4

Previous GeneCards Identifiers for UCP2 Gene

  • GC11M076013
  • GC11M075225
  • GC11M073909
  • GC11M073412
  • GC11M073363
  • GC11M073685
  • GC11M069981

Summaries for UCP2 Gene

Entrez Gene Summary for UCP2 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCP2 Gene

UCP2 (Uncoupling Protein 2) is a Protein Coding gene. Diseases associated with UCP2 include obesity bmiq4 and hyperinsulinemic hypoglycemia, familial, 2. Among its related pathways are Glucose / Energy Metabolism and Metabolism. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for UCP2 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Gene Wiki entry for UCP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP2 Gene

Genomics for UCP2 Gene

Regulatory Elements for UCP2 Gene

Enhancers for UCP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UCP2 on UCSC Golden Path with GeneCards custom track

Promoters for UCP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UCP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UCP2 Gene

Chromosome:
11
Start:
73,974,667 bp from pter
End:
73,983,307 bp from pter
Size:
8,641 bases
Orientation:
Minus strand

Genomic View for UCP2 Gene

Genes around UCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCP2 Gene

Proteins for UCP2 Gene

  • Protein details for UCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55851-UCP2_HUMAN
    Recommended name:
    Mitochondrial uncoupling protein 2
    Protein Accession:
    P55851
    Secondary Accessions:
    • Q4PJH8
    • Q53HM3

    Protein attributes for UCP2 Gene

    Size:
    309 amino acids
    Molecular mass:
    33229 Da
    Quaternary structure:
    • Acts as a dimer forming a proton channel.

neXtProt entry for UCP2 Gene

Proteomics data for UCP2 Gene at MOPED

Post-translational modifications for UCP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UCP2 (UCP2)

No data available for DME Specific Peptides for UCP2 Gene

Domains & Families for UCP2 Gene

Gene Families for UCP2 Gene

Suggested Antigen Peptide Sequences for UCP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55851

UniProtKB/Swiss-Prot:

UCP2_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with UCP2: view

Function for UCP2 Gene

Molecular function for UCP2 Gene

GENATLAS Biochemistry:
uncoupling protein of inner mitochondrial membrane 2,highly homolog to UCP1 and UCP3,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in adipose tissue and muscle,involved in the variation of energy metabolism with a reduced expression in skeletal muscle and intraperitoneal tissue (reduced gene expression in skeletal muscle of obese),regulated by PPARA and PPARG in mice
UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
genes like me logo Genes that share phenotypes with UCP2: view

Animal Models for UCP2 Gene

MGI Knock Outs for UCP2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UCP2 Gene

Localization for UCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCP2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCP2 Gene COMPARTMENTS Subcellular localization image for UCP2 gene
Compartment Confidence
mitochondrion 5
peroxisome 3
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for UCP2 Gene

Pathways & Interactions for UCP2 Gene

genes like me logo Genes that share pathways with UCP2: view

Gene Ontology (GO) - Biological Process for UCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000303 response to superoxide IEA --
GO:0001666 response to hypoxia IEA,IDA 22292025
GO:0006412 translation IBA --
GO:0006810 transport IEA,NAS 9196039
GO:0006839 mitochondrial transport IEA --
genes like me logo Genes that share ontologies with UCP2: view

No data available for SIGNOR curated interactions for UCP2 Gene

Drugs & Compounds for UCP2 Gene

(38) Drugs for UCP2 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational Pharma Sex hormone 1235
Adrenergic Agents Pharma 4886
Contraceptive Agents Pharma 1825
Estradiol 17 beta-cypionate Pharma 1235
Estradiol 3-benzoate Pharma 1235

(42) Additional Compounds for UCP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UCP2: view

Transcripts for UCP2 Gene

Unigene Clusters for UCP2 Gene

Uncoupling protein 2 (mitochondrial, proton carrier):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
SP1: - - - - - - -
SP2: -
SP3:
SP4: - - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - - -

Relevant External Links for UCP2 Gene

GeneLoc Exon Structure for
UCP2
ECgene alternative splicing isoforms for
UCP2

Expression for UCP2 Gene

mRNA expression in normal human tissues for UCP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCP2 Gene

This gene is overexpressed in Whole Blood (x14.7) and Spleen (x7.0).

Protein differential expression in normal tissues from HIPED for UCP2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCP2 Gene



SOURCE GeneReport for Unigene cluster for UCP2 Gene Hs.80658

mRNA Expression by UniProt/SwissProt for UCP2 Gene

P55851-UCP2_HUMAN
Tissue specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.
genes like me logo Genes that share expression patterns with UCP2: view

Protein tissue co-expression partners for UCP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for UCP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCP2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia UCP2 35
  • 92.34 (n)
  • 97.41 (a)
UCP2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ucp2 35
  • 89.97 (n)
  • 96.12 (a)
Ucp2 16
Ucp2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UCP2 35
  • 99.68 (n)
  • 99.35 (a)
UCP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ucp2 35
  • 88.67 (n)
  • 95.47 (a)
cow
(Bos Taurus)
Mammalia UCP2 36
  • 95 (a)
OneToOne
UCP2 35
  • 90.4 (n)
  • 95.47 (a)
oppossum
(Monodelphis domestica)
Mammalia UCP2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCP2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCP2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75881 35
ucp2 35
  • 74.48 (n)
  • 82.74 (a)
African clawed frog
(Xenopus laevis)
Amphibia ucp2-prov 35
zebrafish
(Danio rerio)
Actinopterygii ucp2 35
ucp2 35
  • 73.6 (n)
  • 84.16 (a)
ucp2 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8891 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011676 35
  • 61.81 (n)
  • 62.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dic2 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PUMP1 35
  • 53.9 (n)
  • 52.79 (a)
rice
(Oryza sativa)
Liliopsida Os11g0707800 35
  • 56.69 (n)
  • 50.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10779 36
  • 37 (a)
OneToMany
Species with no ortholog for UCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCP2 Gene

ENSEMBL:
Gene Tree for UCP2 (if available)
TreeFam:
Gene Tree for UCP2 (if available)

Paralogs for UCP2 Gene

genes like me logo Genes that share paralogs with UCP2: view

Variants for UCP2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UCP2 Gene

P55851-UCP2_HUMAN
Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIM:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals.

Sequence variations from dbSNP and Humsavar for UCP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs660339 - 73,978,059(-) TACAG(C/T)CAGCG reference, missense
rs45541732 - 73,977,996(-) CCCCC(A/G)AAGCC reference, missense
rs45486692 - 73,976,894(-) TGGTC(A/G)GAGAT reference, missense
rs45490393 - 73,975,503(-) CCGAG(C/G)CTTCT reference, missense
rs45596837 - 73,975,092(-) GGGTT(C/G)CTGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UCP2 Gene

Variant ID Type Subtype PubMed ID
nsv520299 CNV Loss 19592680

Variation tolerance for UCP2 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.18; 90.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCP2 Gene

HapMap Linkage Disequilibrium report
UCP2
Human Gene Mutation Database (HGMD)
UCP2

Disorders for UCP2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for UCP2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity bmiq4
  • obesity, susceptibility to, bmiq4
hyperinsulinemic hypoglycemia, familial, 2
  • familial hyperinsulinism
hyperinsulinism due to ucp2 deficiency
  • hyperinsulinemic hypoglycemia due to ucp2 deficiency
obesity
  • obesity, association with
neovascular glaucoma
  • secondary angle-closure glaucoma with rubeosis
- elite association - COSMIC cancer census association via MalaCards
Search UCP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UCP2

Genetic Association Database (GAD)
UCP2
Human Genome Epidemiology (HuGE) Navigator
UCP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCP2
genes like me logo Genes that share disorders with UCP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCP2 Gene

Publications for UCP2 Gene

  1. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. (PMID: 11381268) Esterbauer H. … Patsch W. (Nat. Genet. 2001) 2 3 4 23 48 67
  2. Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus. (PMID: 19681913) Crispim D. … Canani L.H. (Clin. Endocrinol. (Oxf) 2010) 3 23
  3. Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain. (PMID: 19833146) Heidema A.G. … Mariman E.C. (Physiol. Behav. 2010) 3 23
  4. Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. (PMID: 19889414) Salpea K.D. … Humphries S.E. (Atherosclerosis 2010) 3 23
  5. Uncoupling protein-2 modulates myocardial excitation-contraction coupling. (PMID: 20056920) Turner J.D. … Thomas A.P. (Circ. Res. 2010) 3 23

Products for UCP2 Gene

Sources for UCP2 Gene

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