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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UCP2 Gene

protein-coding GIFtS: 65
GCID: GC11M073685

uncoupling protein 2 (mitochondrial, proton carrier)

Explore 72 diseases affiliated with
UCP2 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Uncoupling Protein 2 (Mitochondrial, Proton Carrier)¹ ²		UCP 2² ³
SLC25A8¹ ² ³		BMIQ4² ⁵
Solute Carrier Family 25 Member 8² ³		Mitochondrial Uncoupling Protein 2²
UCPH² ³

External Ids:	HGNC: 12518¹	Entrez Gene: 7351²	Ensembl: ENSG00000175567⁷	OMIM: 601693⁵	UniProtKB: P55851³

Export aliases for UCP2 gene to outside databases

Previous GC identifers: GC11M076013 GC11M075225 GC11M073909 GC11M073412 GC11M073363 GC11M069981

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCP2:

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins

(MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as

the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial

membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the

mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact

methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This

gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in

nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851

Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane,

thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Gene Wiki entry for UCP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UCP2 gene promoter:
GR PPAR-alpha NF-1 RelA GR-alpha NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UCP2 promoter sequence

Search SABiosciences Chromatin IP Primers for UCP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13

UCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCP2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M073685: view genomic region (about GC identifiers)

Start:	73,685,712 bp from pter	End:	73,694,352 bp from pter
Size:	8,641 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851 (See protein sequence)

Recommended Name: Mitochondrial uncoupling protein 2

Size: 309 amino acids; 33229 Da

Subunit: Acts as a dimer forming a proton channel (By similarity)

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Secondary accessions: Q4PJH8 Q53HM3

Explore the universe of human proteins at neXtProt for UCP2: NX_P55851

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55851

UCP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003346.2

ENSEMBL proteins:

ENSP00000312029 ENSP00000441147 ENSP00000439951 ENSP00000439706 ENSP00000438230

Reactome Protein details: P55851
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for UCP2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005743	mitochondrial inner membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0031966	mitochondrial membrane	--	--

UCP2 for ontologies About GeneDecksing

UCP2 Antibody Products:

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	ThermoFisher Antibodies for UCP2

Assay Products for UCP2:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for UCP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UCP2 for domains About GeneDecksing

3 InterPro domains/families:

IPR023395 Mt_carrier_dom

IPR002030 Mit_uncoupling

IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry P55851

ProtoNet protein and cluster: P55851

1 Blocks protein family: IPB002030 Mitochondrial brown fat uncoupling protein signature

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851

Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family

Similarity: Contains 3 Solcar repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851

Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane,

thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Genatlas biochemistry entry for UCP2:

uncoupling protein of inner mitochondrial membrane 2,highly homolog to UCP1 and UCP3,dissipating the proton

electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in adipose tissue and

muscle,involved in the variation of energy metabolism with a reduced expression in skeletal muscle and intraperitoneal

tissue (reduced gene expression in skeletal muscle of obese),regulated by PPARA and PPARG in mice

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		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate UCP2 (see all 11):
		hsa-miR-4291 hsa-miR-922 hsa-miR-15a hsa-miR-450b-3p hsa-miR-497 hsa-miR-214 hsa-miR-424 hsa-miR-16

		SwitchGear 3'UTR luciferase reporter plasmid: UCP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for UCP2

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for UCP2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP2

2 GenomeRNAi human phenotypes for UCP2:

Decreased viability

Synthetic lethal with imatinib

Animal Models:
Mouse knock-outs for UCP2: Ucp2^tm1Lowl Ucp2^tm1Rcq
10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ucp2):

behavior/neurological	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	mortality/aging	nervous system	respiratory system

UCP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

The fatty acid cycling model

	Mitochondrial Uncoupling Proteins	1.00			The proton buffering model	1.00
	The fatty acid cycling model	1.00			Energy Metabolism	0.04

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	1.00			The citric acid (TCA) cycle and respiratory electron transport	0.72
	Electron Transport Chain	0.76

Selected targets of HNF1

Selected targets of HNF1

1.00

FOXA2 and FOXA3 transcription factor networks

FOXA2 and FOXA3 transcription factor networks

1.00

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for UCP2

Selected targets of HNF1

3 BioSystems Pathways for UCP2

	Energy Metabolism
	Electron Transport Chain
	FOXA2 and FOXA3 transcription factor networks

5/6 Reactome Pathways for UCP2 (see all 6)

	The proton buffering model
	Mitochondrial Uncoupling Proteins
	Metabolism
	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
	The citric acid (TCA) cycle and respiratory electron transport

UCP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UCP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for UCP2 (P55851³ ENSP00000312029⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAB	P31946³, ENSP00000300161⁴	I2D: score=3 STRING: ENSP00000300161
YWHAG	P61981³, ENSP00000306330⁴	I2D: score=2 STRING: ENSP00000306330
YWHAQ	P27348³, ENSP00000238081⁴	I2D: score=4 STRING: ENSP00000238081
YWHAZ	P63104³, ENSP00000309503⁴	I2D: score=4 STRING: ENSP00000309503
FOXA2	ENSP00000315955⁴	STRING: ENSP00000315955

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000303	response to superoxide	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0006810	transport	NAS	9196039
GO:0006839	mitochondrial transport	IEA	--
GO:0009749	response to glucose stimulus	IEA	--

UCP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UCP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for UCP2

Browse Tocris compounds for UCP2
10/69 Novoseek chemical compound relationships for UCP2 gene (see all 69) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	67.7	87	17131143 (3), 19763737 (2), 20056920 (2), 20030709 (2) (see all 47)
fatty acid	66.8	50	10868951 (2), 12418549 (2), 17855623 (2), 11061990 (2) (see all 36)
glucose	59	98	19272350 (4), 17131143 (4), 18167556 (4), 11904148 (3) (see all 46)
oxygen	57.2	98	18082129 (4), 20056920 (3), 17131143 (3), 15016641 (2) (see all 53)
rosiglitazone	52.1	7	10849580 (2), 19659999 (2), 10548525 (1), 10066437 (1) (see all 5)
hydrogen	51.7	39	18308829 (4), 11278935 (2), 14693721 (1), 16005426 (1) (see all 22)
adp	50.8	12	17131143 (2), 19230380 (1), 11145588 (1), 11171965 (1) (see all 9)
palmitate	46.4	6	17303124 (1), 11278935 (1), 11701434 (1), 11289045 (1) (see all 5)
thiazolidinedione	45.9	8	10849580 (3), 10843184 (1), 11056218 (1)
carbacyclin	43.3	1	12588052 (1)

Search CenterWatch for drugs/clinical trials and news about UCP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UCP2 gene:

NM_003355.2

Unigene Cluster for UCP2:

Uncoupling protein 2 (mitochondrial, proton carrier)

Hs.80658 [show with all ESTs]

Unigene Representative Sequence: AK025742

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310473(uc001oup.1) ENST00000536983 ENST00000544615 ENST00000545212

ENST00000545562 ENST00000543714 ENST00000539764 ENST00000542615 ENST00000541027

ENST00000539330

miRNA Products:		OriGene 3'-UTR Clone: UCP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCP2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate UCP2 (see all 11):
		hsa-miR-4291 hsa-miR-922 hsa-miR-15a hsa-miR-450b-3p hsa-miR-497 hsa-miR-214 hsa-miR-424 hsa-miR-16

		SwitchGear 3'UTR luciferase reporter plasmid: UCP2 3' UTR sequence

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Additional cDNA sequence:

AK025742.1 AK222540.1 AK222557.1 BC011737.2 U76367.1 U82819.1 U94592.1

24/25 DOTS entries (see all 25):

DT.100816705 DT.214741 DT.40117015 DT.120754392 DT.95171778 DT.120754424 DT.120754391 DT.120754427

DT.120754440 DT.95117837 DT.100816708 DT.97759938 DT.120754419 DT.120754431 DT.75133198 DT.95171780

DT.100816706 DT.100816717 DT.120754436 DT.120754438 DT.86854501 DT.95171793 DT.120754417 DT.91847081

24/405 AceView cDNA sequences (see all 405):

BM787454 BF851793 AW328073 BM552598 BF089856 CR626508 CR619395 BI753177

BE795302 H61243 CR624968 BQ055250 BF089839 BC011737 BU189884 BE388233

AW328072 NM_003355 CA311021 CR610551 BU173223 CR616061 BQ066123 BX343473

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UCP2 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	·	10c	·	10d	^	11
SP1:					-		-		-		-		-						-		-
SP2:					-
SP3:
SP4:					-		-		-		-								-		-
SP5:					-		-

ECgene alternative splicing isoforms for UCP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UCP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCCTTTT

About this image

UCP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

White adipocyte-like cells (Differentiation of w...)

Brown adipocyte-like cells (Differentiation of w...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UCP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCP2

SOURCE GeneReport for Unigene cluster: Hs.80658

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851

Tissue specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in

white adipose tissue and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including UCP2:

Mitochondrial Energy Metabolism in human mouse rat

Mitochondria in human mouse rat

Oxidative Stress in human mouse rat

Diabetes in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCP2 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	UCP2⁶	--	82(a)	1 ↔ 1	GL344128.1(57210-65012)
African clawed frog (Xenopus laevis)	Amphibia	ucp2-prov²	uncoupling protein 2	80.07(n)		BC044682.1
zebrafish (Danio rerio)	Actinopterygii	ucp2²	uncoupling protein 2	77.15(n)		30414 BC056737.1
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP011676¹	AGAP011676-PA	61.81(n) 62.5(a)		1280964 XM_552584.3 XP_552584.3
thale cress (Arabidopsis thaliana)	eudicotyledons	PUMP1¹	uncoupling mitochondrial protein 1	53.33(n) 52(a)		824578 NM_115271.4 NP_190979.1
rice (Oryza sativa)	Liliopsida	Os11g0707800¹	hypothetical protein	56.57(n) 50.36(a)		4351228 NM_001075091.1 NP_001068559.2

ENSEMBL Gene Tree for UCP2 (if available)
TreeFam Gene Tree for UCP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UCP2 gene

UCP3² UCP1² SLC25A14² SLC25A11² ENSG00000262660² SLC25A10² SLC25A30² SLC25A27²

11 SIMAP similar genes for UCP2 using alignment to 5 protein entries: UCP2_HUMAN (see all proteins):

UCP1 UCP3 SLC25A10 SLC25A14 SLC25A30 SLC25A34

SLC25A11 SLC25A27 SLC25A22 SLC25A47 SLC25A19

UCP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851

Polymorphism: Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIM:607447]. A

common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in

middle-aged individuals

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3832774^1,2	C	--	69981001(-)	`GAACA-/AGTC AGTCA`	1	--	ds500¹		0	--	--	--	--
rs45520037^1,2	C,F,	--	69981034(-)	`CTCCCC/GCAAAG`	1	--	ds500¹		6		NS WA	292
rs45626332^1,2	C,F,	--	69981240(-)	`TTTGCC/TGGGCC`	1	--	ds500¹		5		NS	174
rs11823767^1,2	C,F,H,	--	69981252(+)	`GAAGGG/TGAGGC`	1	--	ds500¹		8		NS WA NA	300
rs45583331^1,2	C,F,	--	69981341(-)	`AGCCCG/CTGTAG`	1	--	ds500¹		6		NS WA	304
rs45523236^1,2	C,F,	--	69981403(-)	`GAGGAA/CCCACC`	1	--	ds500¹		6		NS WA	306
rs45565136^1,2	C,F,	--	69981518(-)	`AGCCTA/CGCCCA`	1	--	ut3¹		7		NS NA WA	308
rs45567343^1,2	C,F,	--	69981531(-)	`CCCCCG/CACAGC`	1	--	ut3¹		6		NS WA	306
rs45508598^1,2	C,F,	--	69981680(-)	`TTACCT/CACCAC`	1	--	ut3¹		8		NS NA CSA WA	305
rs60141953^1,2		--	69981741(+)	`GGAAGA/GGAAAG`	1	--	ut3¹		2		CSA WA	119

HapMap Linkage Disequilibrium report for UCP2 (73685712 - 73694352 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UCP2
1 CNV: 48880
Human Gene Mutation Database (HGMD): UCP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UCP2 for disorders           About GeneDecksing

OMIM gene information: 601693
OMIM disorders: 607447
20/72 diseases for UCP2 (see all 72):    About MalaCards

neural tube defect obesity type 2 diabetes mellitus insulin resistance

coronary heart disease spina bifida glucose intolerance primary biliary cirrhosis

acute insulin response sleep apnea diabetes mellitus polycystic ovary syndrome

metabolic disorders obstructive jaundice anorexia nervosa fatty liver disease

obesity, variation in morbid obesity jaundice liver disease

2 diseases from the University of Copenhagen DISEASES database for UCP2:

Diabetes mellitus Hyperglycemia

10/31 Novoseek disease relationships for UCP2 gene (see all 31) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	73.5	195	15165610 (6), 19950601 (5), 10102249 (5), 15061987 (4) (see all 89)
insulin sensitivity	48.8	11	9837864 (2), 12153598 (2), 18059082 (2), 16477380 (1) (see all 7)
insulin resistance	46.1	9	15220218 (2), 19272350 (1), 19556617 (1), 17397545 (1) (see all 7)
hyperinsulinemia	40.7	9	14717811 (1), 12588051 (1), 19908126 (1), 10605819 (1) (see all 8)
niddm	38.1	16	9709950 (2), 17916951 (2), 9726246 (2), 9349606 (1) (see all 9)
metabolic disorder	34.6	4	10395193 (1), 12743644 (1), 11080246 (1)
insulinoma	32.5	4	18692019 (2), 11145588 (1), 20206170 (1)
fatty liver	28.2	4	15970480 (2), 15387925 (1), 18846338 (1)
impaired glucose tolerance	27.3	3	19769793 (1), 10382588 (1)
hyperglycemia	23.7	9	19556617 (3), 14679178 (2), 18290312 (2), 18167556 (1) (see all 5)

Genetic Association Database (GAD): UCP2
Human Genome Epidemiology (HuGE) Navigator: UCP2 (134 documents)

Export disorders for UCP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UCP2 gene, integrated from 9 sources (see all 571):
(articles sorted by number of sources associating them with UCP2)

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A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. (PubMed id 11381268)^{1, 2, 4, 9} Esterbauer H.... Patsch W. (2001)
Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. (PubMed id 16373902)^{1, 4, 9} Rudofsky G....Hamann A. (2006)
Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis. (PubMed id 16021520)^{1, 4, 9} Vogler S....Ibrahim S.M. (2005)
Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians. (PubMed id 16167150)^{1, 4, 9} Kovacs P....Baier L.J. (2005)
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. (PubMed id 12915397)^{1, 4, 9} Wang H....Elbein S.C. (2004)
Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women. (PubMed id 15604415)^{1, 4, 9} Oberkofler H....Patsch W. (2005)
Higher obesity risk associated with the exon-8 insertion of the UCP2 gene in a Spanish case-control study. (PubMed id 15165610)^{1, 4, 9} Marti A....Martinez J.A. (2004)
[Additive effects of the variants in the beta(3)-adrenergic receptor and uncoupling protein-2 genes on obesity in Chinese] (PubMed id 15192823)^{1, 4, 9} Sui Y....Yan J.H. (2004)
[Common variants in beta 3-adrenergic-receptor and uncoupling protein-2 genes are associated with type 2 diabetes and obesity] (PubMed id 15061987)^{1, 4, 9} Xiu L.L....Huang Z.M. (2004)
Mutational analysis of the UCP2 core promoter and relationships of variants with obesity. (PubMed id 14627764)^{1, 4, 9} Dalgaard L.T....Pedersen O. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7351	HGNC: 12518	AceView: UCP2	Ensembl:ENSG00000175567	euGenes: HUgn7351
ECgene: UCP2	H-InvDB: UCP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UCP2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/ucp2/

Intellectual Property for UCP2 gene
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Patent Information for UCP2 gene:
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uncoupling protein 2 (mitochondrial, proton carrier)

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UCP2 Gene

uncoupling protein 2 (mitochondrial, proton carrier)

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