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UCP2 Gene

protein-coding   GIFtS: 64
GCID: GC11M073685

Uncoupling Protein 2 (Mitochondrial, Proton Carrier)

(Previous names: body mass index QTL 4, body mass index quantitative trait...)
(Previous symbol: BMIQ4)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Uncoupling Protein 2 (Mitochondrial, Proton Carrier)1 2     UCP 22 3
BMIQ41 2 5     Body Mass Index QTL 41
Solute Carrier Family 25 Member 82 3     Body Mass Index Quantitative Trait 41
SLC25A82 3     Mitochondrial Uncoupling Protein 22
UCPH2 3     

External Ids:    HGNC: 125181   Entrez Gene: 73512   Ensembl: ENSG000001755677   OMIM: 6016935   UniProtKB: P558513   

Export aliases for UCP2 gene to outside databases

Previous GC identifers: GC11M076013 GC11M075225 GC11M073909 GC11M073412 GC11M073363 GC11M069981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UCP2 Gene:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins
(MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred
to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer
mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane.
They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the
different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous
protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal
muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is
5'-UCP3-UCP2-3'. (provided by RefSeq, Jul 2008)

GeneCards Summary for UCP2 Gene:
UCP2 (uncoupling protein 2 (mitochondrial, proton carrier)) is a protein-coding gene. Diseases associated with UCP2 include hyperinsulinism due to ucp2 deficiency, and obesity bmiq4. An important paralog of this gene is UCP3.

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the
form of heat

Gene Wiki entry for UCP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UCP2 gene promoter:
         GR   PPAR-alpha   NF-1   RelA   GR-alpha   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCP2 promoter sequence
   Search Chromatin IP Primers for UCP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13

UCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073685:  view genomic region     (about GC identifiers)

Start:
73,685,712 bp from pter      End:
73,694,352 bp from pter
Size:
8,641 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851 (See protein sequence)
Recommended Name: Mitochondrial uncoupling protein 2  
Size: 309 amino acids; 33229 Da
Subunit: Acts as a dimer forming a proton channel (By similarity)
Secondary accessions: Q4PJH8 Q53HM3

Explore the universe of human proteins at neXtProt for UCP2: NX_P55851

Explore proteomics data for UCP2 at MOPED


See UCP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003346.2  
ENSEMBL proteins: 
 ENSP00000312029   ENSP00000441147   ENSP00000439951   ENSP00000439706   ENSP00000438230  
Reactome Protein details: P55851

UCP2 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for UCP2

UCP2 Antibody Products:

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Abcam antibodies for UCP2
Cloud-Clone Corp. Antibodies for UCP2
ThermoFisher Antibodies for UCP2
LSBio Antibodies in human, mouse, rat for UCP2

UCP2 Assay Products:

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Cloud-Clone Corp. ELISAs for UCP2
Cloud-Clone Corp. CLIAs for UCP2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Uncoupling protein 2
Mitochondrial uncoupling proteins

3 InterPro protein domains:
 IPR023395 Mt_carrier_dom
 IPR002030 Mit_uncoupling
 IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry P55851

ProtoNet protein and cluster: P55851

1 Blocks protein domain: IPB002030 Mitochondrial brown fat uncoupling protein signature

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851
Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
Similarity: Contains 3 Solcar repeats


UCP2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: UCP2_HUMAN, P55851
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the
form of heat

     Genatlas biochemistry entry for UCP2:
uncoupling protein of inner mitochondrial membrane 2,highly homolog to UCP1 and UCP3,dissipating the proton
electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in adipose tissue
and muscle,involved in the variation of energy metabolism with a reduced expression in skeletal muscle and
intraperitoneal tissue (reduced gene expression in skeletal muscle of obese),regulated by PPARA and PPARG in mice

Phenotypes:
     2 GenomeRNAi human phenotypes for UCP2:
 Decreased viability  Synthetic lethal with imatinib 

     10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ucp2):
 behavior/neurological  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
 immune system  integument  mortality/aging  nervous system  respiratory system 

UCP2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for UCP2: Ucp2tm1Lowl Ucp2tm1Rcq

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UCP2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UCP2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCP2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UCP2

miRNA
Products:
    
miRTarBase miRNAs that target UCP2:
hsa-mir-15a-5p (MIRT004046), hsa-mir-484 (MIRT042197)

Block miRNA regulation of human, mouse, rat UCP2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate UCP2 (see all 11):
hsa-miR-4291 hsa-miR-922 hsa-miR-15a hsa-miR-450b-3p hsa-miR-497 hsa-miR-214 hsa-miR-424 hsa-miR-16
SwitchGear 3'UTR luciferase reporter plasmidUCP2 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for UCP2
Predesigned siRNA for gene silencing in human, mouse, rat UCP2

Gene Editing
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GenScript: all cDNA clones in your preferred vector: UCP2 (NM_003355)
Sino Biological Human cDNA Clone for UCP2
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCP2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
UCP2_HUMAN, P55851: Mitochondrion inner membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
nucleus2
peroxisome2
cytosol1
plasma membrane1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane TAS--
GO:0016021integral component of membrane IEA--
GO:0031966mitochondrial membrane ----

UCP2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for UCP2 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
The citric acid (TCA) cycle and respiratory electron transport0.71
Electron Transport Chain0.75
2The fatty acid cycling model
The fatty acid cycling model
Mitochondrial Uncoupling Proteins0.00
The proton buffering model0.00
3Metabolism
Metabolism0.38
4Selected targets of HNF1
Selected targets of HNF1
5FOXA2 and FOXA3 transcription factor networks
FOXA2 and FOXA3 transcription factor networks

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


3 BioSystems Pathways for UCP2
    Electron Transport Chain
Energy Metabolism
FOXA2 and FOXA3 transcription factor networks


2 Reactome Pathways for UCP2
    The proton buffering model
The fatty acid cycling model



UCP2 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including UCP2: 
          Mitochondrial Energy Metabolism in human mouse rat
          Mitochondria in human mouse rat
          Oxidative Stress in human mouse rat
          Diabetes in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for UCP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

Selected Interacting proteins for UCP2 (P558513 ENSP000003120294) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
YWHABP319463, ENSP000003001614I2D: score=3 STRING: ENSP00000300161
YWHAGP619813, ENSP000003063304I2D: score=2 STRING: ENSP00000306330
YWHAQP273483, ENSP000002380814I2D: score=4 STRING: ENSP00000238081
YWHAZP631043, ENSP000003095034I2D: score=4 STRING: ENSP00000309503
UCP1ENSP000002629994STRING: ENSP00000262999
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Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000303response to superoxide IEA--
GO:0001666response to hypoxia IEA--
GO:0006810transport NAS9196039
GO:0006839mitochondrial transport IEA--
GO:0007565female pregnancy IEA--

UCP2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Enzo Life Sciences drugs & compounds for UCP2
  Browse compounds at ApexBio 

Browse Tocris compounds for UCP2

Selected Novoseek inferred chemical compound relationships for UCP2 gene (see all 69)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
atp 67.7 87 17131143 (3), 19763737 (2), 20056920 (2), 20030709 (2) (see all 47)
fatty acid 66.8 50 10868951 (2), 12418549 (2), 17855623 (2), 11061990 (2) (see all 36)
glucose 59 98 19272350 (4), 17131143 (4), 18167556 (4), 11904148 (3) (see all 46)
oxygen 57.2 98 18082129 (4), 20056920 (3), 17131143 (3), 15016641 (2) (see all 53)
rosiglitazone 52.1 7 10849580 (2), 19659999 (2), 10548525 (1), 10066437 (1) (see all 5)
hydrogen 51.7 39 18308829 (4), 11278935 (2), 14693721 (1), 16005426 (1) (see all 22)
adp 50.8 12 17131143 (2), 19230380 (1), 11145588 (1), 11171965 (1) (see all 9)
palmitate 46.4 6 17303124 (1), 11278935 (1), 11701434 (1), 11289045 (1) (see all 5)
thiazolidinedione 45.9 8 10849580 (3), 10843184 (1), 11056218 (1)
carbacyclin 43.3 1 12588052 (1)



UCP2 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for UCP2 gene: 
NM_003355.2  

Unigene Cluster for UCP2:

Uncoupling protein 2 (mitochondrial, proton carrier)
Hs.80658  [show with all ESTs]
Unigene Representative Sequence: AK025742
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000310473(uc001oup.1) ENST00000536983 ENST00000544615 ENST00000545212
ENST00000545562 ENST00000543714 ENST00000539764 ENST00000542615 ENST00000541027
ENST00000539330
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat UCP2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate UCP2 (see all 11):
hsa-miR-4291 hsa-miR-922 hsa-miR-15a hsa-miR-450b-3p hsa-miR-497 hsa-miR-214 hsa-miR-424 hsa-miR-16
SwitchGear 3'UTR luciferase reporter plasmidUCP2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for UCP2
Predesigned siRNA for gene silencing in human, mouse, rat UCP2
Clone
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OriGene clones in human, mouse for UCP2 (see all 8)
OriGene ORF clones in mouse, rat for UCP2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UCP2 (NM_003355)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCP2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCP2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for UCP2
OriGene qSTAR qPCR primer pairs in human, mouse for UCP2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCP2
  QuantiTect SYBR Green Assays in human, mouse, rat UCP2
  QuantiFast Probe-based Assays in human, mouse, rat UCP2

Additional mRNA sequence: 

AK025742.1 AK222540.1 AK222557.1 BC011737.2 U76367.1 U82819.1 U94592.1 

Selected DOTS entries (see all 25):

DT.100816705  DT.214741  DT.40117015  DT.120754392  DT.95171778  DT.120754424  DT.120754391  DT.120754427 
DT.120754440  DT.95117837  DT.100816708  DT.97759938  DT.120754419  DT.120754431  DT.75133198  DT.95171780 
DT.100816706  DT.100816717  DT.120754436  DT.120754438  DT.86854501  DT.95171793  DT.120754417  DT.91847081 

Selected AceView cDNA sequences (see all 405):

CR616377 BE795302 BU189884 CR607585 BQ066123 BE388233 AL555585 BM552598 
CB306948 BU159750 BI769192 AL556236 BC011737 BM920280 BX343473 AW328072 
BP339606 CB054166 AW449394 BU173223 BF089856 CR608184 H61243 CR626508 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for UCP2 (see all 8)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
SP1:              -     -     -     -     -                 -     -                                                         
SP2:              -                                                                                                         
SP3:                                                                                                                        
SP4:              -     -     -     -                       -     -                                                         
SP5:              -     -                                                                                                   


ECgene alternative splicing isoforms for UCP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UCP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTTTCCTTTT
UCP2 Expression
About this image


UCP2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 14) fully expand
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         White adipocyte-like cells
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone Marrow
         HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
 
 Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
         Placenta-derived mesenchymal stem cells (family)
 
 Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
         Placenta-derived mesenchymal stem cells (family)
 
 Thymus (Hematopoietic System)
         Double Negative 2 Thymocytes Thymus
UCP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

UCP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.80658

UniProtKB/Swiss-Prot: UCP2_HUMAN, P55851
Tissue specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed
in white adipose tissue and skeletal muscle

    Pathway & Disease-focused RT2 Profiler PCR Arrays including UCP2: 
          Mitochondrial Energy Metabolism in human mouse rat
          Mitochondria in human mouse rat
          Oxidative Stress in human mouse rat
          Diabetes in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for UCP2
OriGene qSTAR qPCR primer pairs in human, mouse for UCP2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCP2
QuantiTect SYBR Green Assays in human, mouse, rat UCP2
QuantiFast Probe-based Assays in human, mouse, rat UCP2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for UCP2 gene from Selected species (see all 19)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ucp21 , 5 uncoupling protein 2 (mitochondrial, proton carrier)1, 5 89.97(n)1
96.12(a)1
  7 (54.36 cM)5
222281  NM_011671.41  NP_035801.31 
 1004933375 
lizard
(Anolis carolinensis)
Reptilia UCP26
uncoupling protein 2 (mitochondrial, proton carrie...
78(a)
1 ↔ 1
GL344128.1(56659-65376)
African clawed frog
(Xenopus laevis)
Amphibia ucp2-prov2 uncoupling protein 2 80.07(n)    BC044682.1 
zebrafish
(Danio rerio)
Actinopterygii ucp22 uncoupling protein 2 77.15(n)   30414  BC056737.1 
fruit fly
(Drosophila melanogaster)
Insecta Dic26
Dicarboxylate carrier 2
26(a)
many ↔ many
3R(16325764-16327648)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC16
Mitochondrial dicarboxylate carrier, integral memb...
29(a)
1 → many
XII(826977-827873) YLR348C
thale cress
(Arabidopsis thaliana)
eudicotyledons PUMP11 PUMP1 53.9(n)
52.79(a)
  824578  NM_115271.4  NP_190979.1 
rice
(Oryza sativa)
Liliopsida Os11g07078001 Os11g0707800 56.69(n)
50.36(a)
  4351228  NM_001075091.1  NP_001068559.2 


ENSEMBL Gene Tree for UCP2 (if available)
TreeFam Gene Tree for UCP2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for UCP2 gene
UCP32  UCP12  SLC25A142  SLC25A112  ENSG000002626602  SLC25A102  SLC25A302  SLC25A272  
11 SIMAP similar genes for UCP2 using alignment to 5 protein entries:     UCP2_HUMAN (see all proteins):
UCP1    UCP3    SLC25A10    SLC25A14    SLC25A30    SLC25A11
SLC25A34    SLC25A27    SLC25A22    SLC25A47    SLC25A19

UCP2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
UCP2_HUMAN, P55851: Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4)
[MIM:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk
of obesity in middle-aged individuals


Selected SNPs for UCP2 (see all 302)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs105355271,2
C--69982626(+) CAGGA-/CTTCTTTT 1 -- int10--------
rs454431021,2
F--69982627(-) AAAAG-/AAGTCCT 1 -- int15Minor allele frequency- AA:0.41NS 130
rs1928634701,2
--73550875(+) TCTCAC/TAAGGT 1 -- ds50010--------
rs455200371,2
C,F--73550892(-) CTCCCC/GCAAAG 1 -- ds50016Minor allele frequency- G:0.04NS WA 292
rs456263321,2
C,F--73551098(-) TTTGCC/TGGGCC 1 -- ds50015Minor allele frequency- T:0.03NS 174
rs118237671,2
C,F,H--73551110(+) GAAGGG/TGAGGC 1 -- ds50018Minor allele frequency- T:0.04NS WA NA 300
rs1850583171,2
--73551145(+) GCACTC/TCCCAT 1 -- ds50010--------
rs455833311,2
C,F--73551199(-) AGCCCG/CTGTAG 1 -- ds50016Minor allele frequency- C:0.04NS WA 304
rs455232361,2
C,F--73551261(-) GAGGAA/CCCACC 1 -- ds50016Minor allele frequency- C:0.02NS WA 306
rs1433666711,2
--73551304(+) ACCAAC/GACCTC 1 -- ds50010--------

HapMap Linkage Disequilibrium report for UCP2 (73685712 - 73694352 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for UCP2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv520299CNV Loss19592680

Human Gene Mutation Database (HGMD): UCP2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing UCP2
DNA2.0 Custom Variant and Variant Library Synthesis for UCP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601693   
OMIM disorders: 607447  
Selected diseases for UCP2 (see all 70):    
About MalaCards
hyperinsulinism due to ucp2 deficiency    obesity bmiq4    acute insulin response    obstructive jaundice
ascariasis    hyperinsulinism    trichuriasis    morbid obesity
obesity    neural tube defects    diabetic neuropathy    fatty liver disease
insulinoma    obesity, association with    obsessive-compulsive disorder    liver disease
hyperhomocysteinemia    cerebrovascular disease    glucose intolerance    uremia

2 diseases from the University of Copenhagen DISEASES database for UCP2:
Diabetes mellitus     Hyperglycemia

UCP2 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for UCP2 gene (see all 31)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
obesity 73.5 195 15165610 (6), 19950601 (5), 10102249 (5), 15061987 (4) (see all 89)
insulin sensitivity 48.8 11 9837864 (2), 12153598 (2), 18059082 (2), 16477380 (1) (see all 7)
insulin resistance 46.1 9 15220218 (2), 19272350 (1), 19556617 (1), 17397545 (1) (see all 7)
hyperinsulinemia 40.7 9 14717811 (1), 12588051 (1), 19908126 (1), 10605819 (1) (see all 8)
niddm 38.1 16 9709950 (2), 17916951 (2), 9726246 (2), 9349606 (1) (see all 9)
metabolic disorder 34.6 4 10395193 (1), 12743644 (1), 11080246 (1)
insulinoma 32.5 4 18692019 (2), 11145588 (1), 20206170 (1)
fatty liver 28.2 4 15970480 (2), 15387925 (1), 18846338 (1)
impaired glucose tolerance 27.3 3 19769793 (1), 10382588 (1)
hyperglycemia 23.7 9 19556617 (3), 14679178 (2), 18290312 (2), 18167556 (1) (see all 5)

Genetic Association Database (GAD): UCP2
Human Genome Epidemiology (HuGE) Navigator: UCP2 (134 documents)

Export disorders for UCP2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for UCP2 gene, integrated from 10 sources (see all 596):
(articles sorted by number of sources associating them with UCP2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. (PubMed id 11381268)1, 2, 3, 4, 9 Esterbauer H.... Patsch W. (Nat. Genet. 2001)
  2. [Study on polymorphism of UCP2 gene in Chengdu simple obesity and normal-weight people and a preliminary investigation of its relationship with gut bacteria]. (PubMed id 19950601)1, 4, 9 Zuo H.J....Pei X.F. (Sichuan Da Xue Xue Bao Yi Xue Ban 2009)
  3. Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men. (PubMed id 19155787)1, 4, 9 Matsunaga T....Nishiyama T. (J. Hypertens. 2009)
  4. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. (PubMed id 16373902)1, 4, 9 Rudofsky G....Hamann A. (Diabetes Care 2006)
  5. Is UCP2 gene polymorphism associated with decreased resting energy expenditure in nondialyzed chronic kidney disease patients? (PubMed id 18940651)1, 4, 9 Avesani C.M....Cuppari L. (J Ren Nutr 2008)
  6. Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk? (PubMed id 18839467)1, 4, 9 Heil S.G....Blom H.J. (Clin. Chem. Lab. Med. 2008)
  7. Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis. (PubMed id 16021520)1, 4, 9 Vogler S....Ibrahim S.M. (J. Mol. Med. 2005)
  8. Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians. (PubMed id 16167150)1, 4, 9 Kovacs P....Baier L.J. (Diabetologia 2005)
  9. Simple and rapid detection of uncoupling protein-2 - 866G/A polymorphism by mutagenically separated polymerase chain reaction. (PubMed id 15149891)1, 4, 9 Zhang B....Saku K. ( international journal of clinical chemistry 2004)
  10. Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. (PubMed id 12915397)1, 4, 9 Wang H....Elbein S.C. (Am. J. Physiol. Endocrinol. Metab. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7351 HGNC: 12518 AceView: UCP2 Ensembl:ENSG00000175567 euGenes: HUgn7351
ECgene: UCP2 H-InvDB: UCP2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UCP2 Pharmacogenomics, SNPs, Pathways
NIEHS-SNPshttp://egp.gs.washington.edu/data/ucp2/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UCP2 gene:
Search GeneIP for patents involving UCP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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