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Aliases for UCP1 Gene

Aliases for UCP1 Gene

  • Uncoupling Protein 1 (Mitochondrial, Proton Carrier) 2 3
  • Solute Carrier Family 25 Member 7 3 4
  • Thermogenin 3 4
  • SLC25A7 3 4
  • UCP 3 4
  • UCP 1 4

External Ids for UCP1 Gene

Previous HGNC Symbols for UCP1 Gene

  • UCP

Previous GeneCards Identifiers for UCP1 Gene

  • GC04M142344
  • GC04M141798
  • GC04M141947
  • GC04M142058
  • GC04M141838
  • GC04M141700
  • GC04M141480
  • GC04M137211

Summaries for UCP1 Gene

Entrez Gene Summary for UCP1 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCP1 Gene

UCP1 (Uncoupling Protein 1 (Mitochondrial, Proton Carrier)) is a Protein Coding gene. Diseases associated with UCP1 include multiple symmetric lipomatosis and multiple symmetrical lipomatosis. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include oxidative phosphorylation uncoupler activity. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for UCP1 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Gene Wiki entry for UCP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP1 Gene

Genomics for UCP1 Gene

Regulatory Elements for UCP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UCP1 Gene

Chromosome:
4
Start:
140,559,394 bp from pter
End:
140,568,902 bp from pter
Size:
9,509 bases
Orientation:
Minus strand

Genomic View for UCP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCP1 Gene

Proteins for UCP1 Gene

  • Protein details for UCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25874-UCP1_HUMAN
    Recommended name:
    Mitochondrial brown fat uncoupling protein 1
    Protein Accession:
    P25874
    Secondary Accessions:
    • Q13218
    • Q4KMZ3
    • Q68G66

    Protein attributes for UCP1 Gene

    Size:
    307 amino acids
    Molecular mass:
    33005 Da
    Quaternary structure:
    • Acts as a dimer forming a proton channel

neXtProt entry for UCP1 Gene

Proteomics data for UCP1 Gene at MOPED

Post-translational modifications for UCP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UCP1 (UCP1)

No data available for DME Specific Peptides for UCP1 Gene

Domains & Families for UCP1 Gene

Gene Families for UCP1 Gene

Suggested Antigen Peptide Sequences for UCP1 Gene

Graphical View of Domain Structure for InterPro Entry

P25874

UniProtKB/Swiss-Prot:

UCP1_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with UCP1: view

Function for UCP1 Gene

Molecular function for UCP1 Gene

GENATLAS Biochemistry:
uncoupling protein of inner mitochondrial membrane 1,dissipating the proton electrochemical gradient and uncoupling fuel oxidation from ADP-ATP conversion,expressed in brown adipose tissue,regulated by PPARA and PPARG in mice,with a minor role of the 5utr polymorphism in obesity and diabetes
UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Gene Ontology (GO) - Molecular Function for UCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017077 oxidative phosphorylation uncoupler activity IEA --
genes like me logo Genes that share ontologies with UCP1: view
genes like me logo Genes that share phenotypes with UCP1: view

Animal Models for UCP1 Gene

MGI Knock Outs for UCP1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for UCP1 Gene

Localization for UCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCP1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCP1 Gene COMPARTMENTS Subcellular localization image for UCP1 gene
Compartment Confidence
mitochondrion 5
nucleus 2
peroxisome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for UCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 9054939
GO:0005740 mitochondrial envelope --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UCP1: view

Pathways & Interactions for UCP1 Gene

genes like me logo Genes that share pathways with UCP1: view

PCR Array Products

SIGNOR curated interactions for UCP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006839 mitochondrial transport IEA --
GO:0015992 proton transport TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with UCP1: view

Drugs & Compounds for UCP1 Gene

(27) Drugs for UCP1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bezafibrate Approved Pharma Agonist 11
Levothyroxine Approved Pharma 0
Mifepristone Approved, Investigational Pharma Antagonist Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist 132
Nitric Oxide Approved Pharma 540
Norepinephrine Approved Pharma 206

(35) Additional Compounds for UCP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3,3-dihexyloxacarbocyanine iodide
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
alpha-ketoisocaproate
aspartate
Carbon
genes like me logo Genes that share compounds with UCP1: view

Transcripts for UCP1 Gene

mRNA/cDNA for UCP1 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCP1 Gene

Uncoupling protein 1 (mitochondrial, proton carrier):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for UCP1 Gene

GeneLoc Exon Structure for
UCP1
ECgene alternative splicing isoforms for
UCP1

Expression for UCP1 Gene

mRNA expression in normal human tissues for UCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCP1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x16.0), Breast - Mammary Tissue (x6.6), and Heart - Atrial Appendage (x4.9).

Protein differential expression in normal tissues from HIPED for UCP1 Gene

This gene is overexpressed in Adrenal (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCP1 Gene



SOURCE GeneReport for Unigene cluster for UCP1 Gene Hs.249211

mRNA Expression by UniProt/SwissProt for UCP1 Gene

P25874-UCP1_HUMAN
Tissue specificity: Brown adipose tissue.
genes like me logo Genes that share expression patterns with UCP1: view

Protein tissue co-expression partners for UCP1 Gene

Primer Products

In Situ Assay Products

Orthologs for UCP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UCP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UCP1 35
  • 84.7 (n)
  • 83.28 (a)
UCP1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCP1 35
  • 80.62 (n)
  • 76.74 (a)
UCP1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ucp1 35
  • 79.98 (n)
  • 79.87 (a)
Ucp1 16
Ucp1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UCP1 35
  • 96.83 (n)
  • 96.34 (a)
UCP1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ucp1 35
  • 79.54 (n)
  • 79.87 (a)
oppossum
(Monodelphis domestica)
Mammalia UCP1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCP1 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ucp1 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dic1 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10779 36
  • 32 (a)
OneToMany
Species with no ortholog for UCP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCP1 Gene

ENSEMBL:
Gene Tree for UCP1 (if available)
TreeFam:
Gene Tree for UCP1 (if available)

Paralogs for UCP1 Gene

(9) SIMAP similar genes for UCP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UCP1: view

Variants for UCP1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UCP1 Gene

P25874-UCP1_HUMAN
The Thr-64 polymorphism is associated with an increased waist-to-hip ratio. The Leu-229 polymorphism is associated with susceptibility to type II diabetes mellitus

Sequence variations from dbSNP and Humsavar for UCP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_022840 -
VAR_022841 -

Structural Variations from Database of Genomic Variants (DGV) for UCP1 Gene

Variant ID Type Subtype PubMed ID
nsv880165 CNV Loss 21882294
nsv830088 CNV Gain 17160897

Variation tolerance for UCP1 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCP1 Gene

HapMap Linkage Disequilibrium report
UCP1
Human Gene Mutation Database (HGMD)
UCP1

Disorders for UCP1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for UCP1 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
multiple symmetric lipomatosis
  • lipodystrophy, cephalothoracic
multiple symmetrical lipomatosis
  • lipomatosis, familial benign cervical
lipomatosis
  • benign symmetrical lipomatosis
obesity
  • obesity, association with
acute insulin response
- elite association
Search UCP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UCP1

Genetic Association Database (GAD)
UCP1
Human Genome Epidemiology (HuGE) Navigator
UCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCP1
genes like me logo Genes that share disorders with UCP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCP1 Gene

Publications for UCP1 Gene

  1. Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4. (PMID: 2380264) Cassard A.M. … Ricquier D. (J. Cell. Biochem. 1990) 2 23 67
  2. Oxygen recovery up-regulates avian UCP and ANT in newly hatched ducklings. (PMID: 19816693) Rey B. … Duchamp C. (J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 2010) 23 67
  3. Perspective: Does brown fat protect against diseases of aging? (PMID: 19969105) Mattson M.P. (Ageing Res. Rev. 2010) 23 67
  4. Role of Receptor-Interacting Protein 140 in human fat cells. (PMID: 20205832) Mejhert N. … Dahlman I. (BMC Endocr Disord 2010) 23 67
  5. The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes. (PMID: 19444646) Jia J.J. … Jois M. (Mol. Biol. Rep. 2010) 23 67

Products for UCP1 Gene

Sources for UCP1 Gene

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