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UCP1 Gene(Protein Coding)

Uncoupling Protein 1

GCID:
GC04M140559
GIFtS:
63
Genes Participants
UDN Logo

Aliases for UCP1 Gene

Aliases for UCP1 Gene

  • Uncoupling Protein 1 2 3 5
  • Uncoupling Protein 1 (Mitochondrial, Proton Carrier) 2 3
  • Solute Carrier Family 25 Member 7 3 4
  • Thermogenin 3 4
  • SLC25A7 3 4
  • UCP 3 4
  • Mitochondrial Brown Fat Uncoupling Protein 1 3
  • UCP 1 4

External Ids for UCP1 Gene

Previous HGNC Symbols for UCP1 Gene

  • UCP

Previous GeneCards Identifiers for UCP1 Gene

  • GC04M142344
  • GC04M141798
  • GC04M141947
  • GC04M142058
  • GC04M141838
  • GC04M141700
  • GC04M141480
  • GC04M137211

Summaries for UCP1 Gene

Entrez Gene Summary for UCP1 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCP1 Gene

UCP1 (Uncoupling Protein 1) is a Protein Coding gene. Diseases associated with UCP1 include Obesity and Obesity Susceptibility, Ucp1-Related. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Mitochondrial Uncoupling Proteins. GO annotations related to this gene include oxidative phosphorylation uncoupler activity. An important paralog of this gene is UCP2.

UniProtKB/Swiss-Prot for UCP1 Gene

  • Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).

Gene Wiki entry for UCP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP1 Gene

Genomics for UCP1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for UCP1 Gene

Enhancers for UCP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G140717 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.1 -150.9 -150871 5.2 PKNOX1 ZNF146 JUN SIN3A ZNF384 ARID3A FOXK2 NFE2 FOS ZNF652 TBC1D9 UCP1 ENSG00000248335
GH04G140725 1.5 Ensembl ENCODE dbSUPER 10.1 -159.1 -159109 5.5 FOXA2 MLX ARID4B SIN3A FEZF1 GATA2 FOS SP5 JUNB PPARG TBC1D9 UCP1 ENSG00000248335
GH04G140295 1.4 FANTOM5 Ensembl ENCODE 9.5 +272.4 272394 2.0 ZFP64 FEZF1 EGR1 ZNF366 FOS EGR2 YY2 USF2 CEBPB ZEB2 SCOC UCP1 MAML3 NDUFB4P9
GH04G140639 1.2 Ensembl ENCODE 10.4 -72.2 -72161 3.9 FOXA2 ATF1 MLX DMAP1 ZNF48 YY1 ZNF766 FOS SP5 JUNB ENSG00000248335 UCP1 CLGN GC04M140642 ENSG00000248621
GH04G140753 1.3 ENCODE dbSUPER 9.5 -187.2 -187205 4.3 FOXA2 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 FOS TBC1D9 ENSG00000248335 UCP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UCP1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UCP1 gene promoter:

Genomic Location for UCP1 Gene

Chromosome:
4
Start:
140,559,394 bp from pter
End:
140,568,902 bp from pter
Size:
9,509 bases
Orientation:
Minus strand

Genomic View for UCP1 Gene

Genes around UCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UCP1 Gene

Proteins for UCP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for UCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25874-UCP1_HUMAN
    Recommended name:
    Mitochondrial brown fat uncoupling protein 1
    Protein Accession:
    P25874
    Secondary Accessions:
    • Q13218
    • Q4KMZ3
    • Q68G66

    Protein attributes for UCP1 Gene

    Size:
    307 amino acids
    Molecular mass:
    33005 Da
    Quaternary structure:
    • Most probably functions as a monomer. Binds one purine nucleotide per monomer (By similarity). However, has also been suggested to function as a homodimer or a homotetramer (PubMed:24196960). Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity (PubMed:24196960).

neXtProt entry for UCP1 Gene

Protein Expression for UCP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for UCP1 Gene

  • May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.
  • May undergo ubiquitin-mediated proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UCP1 (UCP1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for UCP1

No data available for DME Specific Peptides for UCP1 Gene

Domains & Families for UCP1 Gene

Gene Families for UCP1 Gene

HGNC:
IUPHAR :

Protein Domains for UCP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UCP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25874

UniProtKB/Swiss-Prot:

UCP1_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with UCP1: view

Function for UCP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for UCP1 Gene

GENATLAS Biochemistry:
uncoupling protein of inner mitochondrial membrane 1,dissipating the proton electrochemical gradient and uncoupling fuel oxidation from ADP-ATP conversion,expressed in brown adipose tissue,regulated by PPARA and PPARG in mice,with a minor role of the 5utr polymorphism in obesity and diabetes
UniProtKB/Swiss-Prot EnzymeRegulation:
Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species.
UniProtKB/Swiss-Prot Function:
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).

Gene Ontology (GO) - Molecular Function for UCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017077 oxidative phosphorylation uncoupler activity IEA,ISS --
GO:0022857 transmembrane transporter activity IDA 24196960
GO:0032555 purine ribonucleotide binding ISS,IEA --
GO:0036041 long-chain fatty acid binding ISS,IEA --
GO:1901612 cardiolipin binding ISS --
genes like me logo Genes that share ontologies with UCP1: view
genes like me logo Genes that share phenotypes with UCP1: view

Animal Models for UCP1 Gene

MGI Knock Outs for UCP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for UCP1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UCP1 Gene

Localization for UCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCP1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCP1 gene
Compartment Confidence
mitochondrion 5
extracellular 2
peroxisome 2
nucleus 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 9054939
GO:0005740 mitochondrial envelope IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with UCP1: view

Pathways & Interactions for UCP1 Gene

genes like me logo Genes that share pathways with UCP1: view

SIGNOR curated interactions for UCP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002024 diet induced thermogenesis IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006839 mitochondrial transport IEA --
genes like me logo Genes that share ontologies with UCP1: view

Drugs & Compounds for UCP1 Gene

Products:

  1. Drug

(32) Drugs for UCP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(30) Additional Compounds for UCP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UCP1: view

Transcripts for UCP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for UCP1 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCP1 Gene

Uncoupling protein 1 (mitochondrial, proton carrier):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for UCP1 Gene

GeneLoc Exon Structure for
UCP1
ECgene alternative splicing isoforms for
UCP1

Expression for UCP1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCP1 Gene

mRNA expression in normal human tissues for UCP1 Gene
mRNA expression by BioGPS for UCP1 GenemRNA expression by GTEx for UCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCP1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x16.0), Breast - Mammary Tissue (x6.6), and Heart - Atrial Appendage (x4.9).

Protein differential expression in normal tissues from HIPED for UCP1 Gene

This gene is overexpressed in Adrenal (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCP1 Gene



Protein tissue co-expression partners for UCP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UCP1 Gene:

UCP1

SOURCE GeneReport for Unigene cluster for UCP1 Gene:

Hs.249211

mRNA Expression by UniProt/SwissProt for UCP1 Gene:

P25874-UCP1_HUMAN
Tissue specificity: Brown adipose tissue.

Evidence on tissue expression from TISSUES for UCP1 Gene

  • Muscle(2.7)
  • Nervous system(2.3)
  • Blood(2.2)
  • Thyroid gland(2.2)
  • Liver(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with UCP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UCP1 Gene

Orthologs for UCP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia UCP1 34 35
  • 96.83 (n)
cow
(Bos Taurus)
 Mammalia UCP1 35 34
  • 84.7 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia UCP1 34 35
  • 80.62 (n)
mouse
(Mus musculus)
 Mammalia Ucp1 34 16 35
  • 79.98 (n)
rat
(Rattus norvegicus)
 Mammalia Ucp1 34
  • 79.54 (n)
oppossum
(Monodelphis domestica)
 Mammalia UCP1 35
  • 65 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia UCP1 35
  • 64 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii ucp1 35
  • 61 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Dic1 35
  • 28 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes DIC1 35
  • 29 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10779 35
  • 32 (a)
 OneToMany
Species where no ortholog for UCP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCP1 Gene

ENSEMBL:
Gene Tree for UCP1 (if available)
TreeFam:
Gene Tree for UCP1 (if available)

Paralogs for UCP1 Gene

Paralogs for UCP1 Gene

(9) SIMAP similar genes for UCP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UCP1: view

Variants for UCP1 Gene

Sequence variations from dbSNP and Humsavar for UCP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000016299 -- 140,568,792(+) AGTTC(C/G)TTTCC utr-variant-5-prime
rs1000023733 -- 140,556,515(+) GCGGA(A/G)AACCA utr-variant-3-prime
rs1000081543 -- 140,567,204(+) GCATT(C/G)GTCCA intron-variant
rs1000121916 -- 140,568,168(+) ACGCG(C/G)AGATG intron-variant
rs1000305568 -- 140,562,797(+) GACTT(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCP1 Gene

Variant ID Type Subtype PubMed ID
nsv830088 CNV gain 17160897

Variation tolerance for UCP1 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCP1 Gene

Human Gene Mutation Database (HGMD)
UCP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UCP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCP1 Gene

Disorders for UCP1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for UCP1 Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
obesity susceptibility, ucp1-related
  • obesity, susceptibility to
lipomatosis, multiple symmetric
  • multiple symmetric lipomatosis
lipomatosis
  • benign symmetrical lipomatosis
multiple symmetrical lipomatosis
  • lipomatosis, familial benign cervical
- elite association - COSMIC cancer census association via MalaCards
Search UCP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UCP1

Genetic Association Database (GAD)
UCP1
Human Genome Epidemiology (HuGE) Navigator
UCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCP1
genes like me logo Genes that share disorders with UCP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCP1 Gene

Publications for UCP1 Gene

  1. Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4. (PMID: 2380264) Cassard A.M. … Ricquier D. (J. Cell. Biochem. 1990) 2 3 4 22 64
  2. A haplotype at the UCP1 gene locus contributes to genetic risk for type 2 diabetes in Asian Indians (CURES-72). (PMID: 19943796) Vimaleswaran K.S. … Mohan V. (Metab Syndr Relat Disord 2010) 3 22 46 64
  3. UCP1 -3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity. (PMID: 19474520) Labruna G. … Sacchetti L. (J. Endocrinol. Invest. 2009) 3 22 46 64
  4. Low-calorie diet-induced reduction in serum HDL cholesterol is ameliorated in obese women with the -3826 G allele in the uncoupling protein-1 gene. (PMID: 19966534) Hamada T. … Sakane N. (Tohoku J. Exp. Med. 2009) 3 22 46 64
  5. Association of UCP1 genetic polymorphisms with blood pressure among Korean female subjects. (PMID: 18955781) Cha M.H. … Yoon Y. (J. Korean Med. Sci. 2008) 3 22 46 64

Products for UCP1 Gene

Sources for UCP1 Gene

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