Aliases for UCP1 Gene
External Ids for UCP1 Gene
Previous HGNC Symbols for UCP1 Gene
Previous GeneCards Identifiers for UCP1 Gene
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
GeneCards Summary for UCP1 Gene
UCP1 (Uncoupling Protein 1) is a Protein Coding gene. Diseases associated with UCP1 include Obesity and Obesity Susceptibility, Ucp1-Related. Among its related pathways are PPAR signaling pathway and Adipogenesis. GO annotations related to this gene include oxidative phosphorylation uncoupler activity. An important paralog of this gene is UCP2.
UniProtKB/Swiss-Prot for UCP1 Gene
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.