Aliases for UCP1 Gene
Aliases for UCP1 Gene
External Ids for UCP1 Gene
- HGNC: 12517
- Entrez Gene: 7350
- Ensembl: ENSG00000109424
- OMIM: 113730
- UniProtKB: P25874
Previous HGNC Symbols for UCP1 Gene
- UCP
Previous GeneCards Identifiers for UCP1 Gene
- GC04M142344
- GC04M141798
- GC04M141947
- GC04M142058
- GC04M141838
- GC04M141700
- GC04M141480
- GC04M137211
Summaries for UCP1 Gene
-
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
GeneCards Summary for UCP1 Gene
UCP1 (Uncoupling Protein 1) is a Protein Coding gene. Diseases associated with UCP1 include Body Mass Index Quantitative Trait Locus 11 and Lipomatosis, Multiple Symmetric. Among its related pathways are The fatty acid cycling model and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include oxidative phosphorylation uncoupler activity. An important paralog of this gene is UCP3.
UniProtKB/Swiss-Prot for UCP1 Gene
-
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).
Additional gene information for UCP1 Gene
- Monarch Initiative
- Search for UCP1 at DataMed
- Search for UCP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP1 Gene
Genomics for UCP1 Gene
GeneHancer (GH) Regulatory Elements for UCP1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04I140568 | Enhancer | 0.5 | Ensembl | 550.8 | -0.1 | -58 | 1.1 | CTCF SUZ12 POLR2A SIN3A EZH2 | UCP1 CLGN LOC101927516 RN7SL152P | |
GH04I140567 | Enhancer | 0.3 | Ensembl | 550.8 | +0.9 | 901 | 0.4 | EZH2 | UCP1 CLGN ELMOD2 | |
GH04I140753 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 9.5 | -187.2 | -187205 | 4.3 | ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 SP3 KAT8 | TBC1D9 GC04P140757 ENSG00000273472 ENSG00000248335 UCP1 | |
GH04I140372 | Promoter/Enhancer | 1.5 | Ensembl ENCODE | 10.6 | +195.3 | 195272 | 2.2 | HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B | SCOC-AS1 CLGN UCP1 SCOC | |
GH04I140725 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 10.1 | -159.1 | -159108 | 5.5 | CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 ETS1 ATF7 FOS | TBC1D9 UCP1 ENSG00000248335 |
Regulatory Element Products
Genomic Locations for UCP1 Gene
- chr4:140,559,394-140,568,902
- (GRCh38/hg38)
- Size:
- 9,509 bases
- Orientation:
- Minus strand
- chr4:141,480,588-141,489,959
- (GRCh37/hg19)
Genomic View for UCP1 Gene
- Cytogenetic band:
-
- 4q31.1 by Ensembl
- 4q31.1 by Entrez Gene
- 4q31.1 by HGNC


RefSeq DNA sequence for UCP1 Gene
Proteins for UCP1 Gene
-
Protein details for UCP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25874-UCP1_HUMAN
- Recommended name:
- Mitochondrial brown fat uncoupling protein 1
- Protein Accession:
- P25874
- Q13218
- Q4KMZ3
- Q68G66
Protein attributes for UCP1 Gene
- Size:
- 307 amino acids
- Molecular mass:
- 33005 Da
- Quaternary structure:
-
- Most probably functions as a monomer. Binds one purine nucleotide per monomer (By similarity). However, has also been suggested to function as a homodimer or a homotetramer (PubMed:24196960). Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity (PubMed:24196960).
Protein Expression for UCP1 Gene
Post-translational modifications for UCP1 Gene
- May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.
- May undergo ubiquitin-mediated proteasomal degradation.
Other Protein References for UCP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
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No data available for DME Specific Peptides for UCP1 Gene
Domains & Families for UCP1 Gene
Gene Families for UCP1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for UCP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for UCP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25874- Family:
-
- Belongs to the mitochondrial carrier (TC 2.A.29) family.
Function for UCP1 Gene
Molecular function for UCP1 Gene
- GENATLAS Biochemistry:
- uncoupling protein of inner mitochondrial membrane 1,dissipating the proton electrochemical gradient and uncoupling fuel oxidation from ADP-ATP conversion,expressed in brown adipose tissue,regulated by PPARA and PPARG in mice,with a minor role of the 5utr polymorphism in obesity and diabetes
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species.
- UniProtKB/Swiss-Prot Function:
- Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0017077 | oxidative phosphorylation uncoupler activity | IEA,ISS | -- |
GO:0022857 | transmembrane transporter activity | IDA | 24196960 |
GO:0032555 | purine ribonucleotide binding | IEA,ISS | -- |
GO:0036041 | long-chain fatty acid binding | ISS,IEA | -- |
GO:1901612 | cardiolipin binding | ISS | -- |
Phenotypes for UCP1 Gene
- MGI mutant phenotypes for UCP1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for UCP1:
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miRNA for UCP1 Gene
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UCP1 Gene
Localization for UCP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for UCP1 Gene
- Mitochondrion inner membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IDA | 9054939 |
GO:0005740 | mitochondrial envelope | IEA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for UCP1 Gene
Pathways & Interactions for UCP1 Gene
Pathways by source for UCP1 Gene
1 Cell Signaling Technology pathway for UCP1 Gene
3 BioSystems pathways for UCP1 Gene
3 KEGG pathways for UCP1 Gene
1 GeneGo (Thomson Reuters) pathway for UCP1 Gene
Interacting Proteins for UCP1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002024 | diet induced thermogenesis | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006810 | transport | IEA | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0006839 | mitochondrial transport | IBA | -- |
Transcripts for UCP1 Gene
mRNA/cDNA for UCP1 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for UCP1 Gene
CRISPR Products
-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for UCP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: |
Expression for UCP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
- Thoracic Committed Brown Preadipocytes Thoracic Brown Adipose Depot
- Lumbar Committed Brown Preadipocytes Lumbar Brown Adipose Depot
- Cervical Brown Adipocyte Cells Cervical Brown Adipose Depot
- Thoracic Brown Adipocyte Cells Thoracic Brown Adipose Depot
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for UCP1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of UCP1 Gene:
UCP1SOURCE GeneReport for Unigene cluster for UCP1 Gene:
Hs.249211mRNA Expression by UniProt/SwissProt for UCP1 Gene:
P25874-UCP1_HUMANEvidence on tissue expression from TISSUES for UCP1 Gene
- Muscle(2.7)
- Nervous system(2.3)
- Blood(2.2)
- Thyroid gland(2.2)
- Liver(2)
- Pancreas(2)
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-
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-
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No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UCP1 Gene
Orthologs for UCP1 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | UCP1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | UCP1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | UCP1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ucp1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ucp1 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | UCP1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | UCP1 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | ucp1 34 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | Dic1 34 |
|
ManyToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DIC1 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10779 34 |
|
OneToMany |
- Species where no ortholog for UCP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for UCP1 Gene
Paralogs for UCP1 Gene
(9) SIMAP similar genes for UCP1 Gene using alignment to 2 proteins:
Variants for UCP1 Gene
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000016299 | -- | 140,568,792(-) | C/G | 5_prime_UTR_variant | |
rs1000023733 | -- | 140,556,515(-) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs1000081543 | -- | 140,567,204(-) | C/G | intron_variant | |
rs1000121916 | -- | 140,568,168(-) | C/G | intron_variant | |
rs1000305568 | -- | 140,562,797(-) | A/G | intron_variant |
Additional Variant Information for UCP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCP1 Gene
Disorders for UCP1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
body mass index quantitative trait locus 11 |
|
|
lipomatosis, multiple symmetric |
|
|
lipomatosis |
|
|
multiple symmetrical lipomatosis |
|
|
overnutrition |
|
|
Additional Disease Information for UCP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for UCP1 Gene
Publications for UCP1 Gene
- Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4. (PMID: 2380264) Cassard AM … Ricquier D (Journal of cellular biochemistry 1990) 2 3 4 22 58
- A haplotype at the UCP1 gene locus contributes to genetic risk for type 2 diabetes in Asian Indians (CURES-72). (PMID: 19943796) Vimaleswaran KS … Mohan V (Metabolic syndrome and related disorders 2010) 3 22 44 58
- UCP1 -3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity. (PMID: 19474520) Labruna G … Sacchetti L (Journal of endocrinological investigation 2009) 3 22 44 58
- Low-calorie diet-induced reduction in serum HDL cholesterol is ameliorated in obese women with the -3826 G allele in the uncoupling protein-1 gene. (PMID: 19966534) Hamada T … Sakane N (The Tohoku journal of experimental medicine 2009) 3 22 44 58
- Association of UCP1 genetic polymorphisms with blood pressure among Korean female subjects. (PMID: 18955781) Cha MH … Yoon Y (Journal of Korean medical science 2008) 3 22 44 58
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- Overview of 116 available UCP1 gene related products
- genomics-online: primer clones - Search results for 116 available UCP1 gene related products
- Overview of 116 available UCP1 gene related products
- genomics-online: shRNA clones - Search results for 116 available UCP1 gene related products
- Overview of 116 available UCP1 gene related products
Sources for UCP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew