Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UCP1 Gene

protein-coding GIFtS: 65
GCID: GC04M141480

Uncoupling Protein 1 (Mitochondrial, Proton Carrier)

(Previous symbol: UCP)

38 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Uncoupling Protein 1 (Mitochondrial, Proton Carrier)¹ ²		Mitochondrial Brown Fat Uncoupling Protein 1²
UCP¹ ² ³		thermogenin²
Solute Carrier Family 25 Member 7² ³		Thermogenin³
SLC25A7² ³		UCP 1³

External Ids:	HGNC: 12517¹	Entrez Gene: 7350²	Ensembl: ENSG00000109424⁷	OMIM: 113730⁵	UniProtKB: P25874³

ORGUL members:
	NONCODE¹⁴:n340238

Export aliases for UCP1 gene to outside databases

Previous GC identifers: GC04M142344 GC04M141798 GC04M141947 GC04M142058 GC04M141838 GC04M141700 GC04M137211

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCP1 Gene:

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs

separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the

mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane

and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the

mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact

methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This

gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. (provided by

RefSeq, Jul 2008)

GeneCards Summary for UCP1 Gene:

UCP1 (uncoupling protein 1 (mitochondrial, proton carrier)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with UCP1 include multiple symmetric lipomatosis, and multiple symmetrical lipomatosis, and among its related super-pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and The proton buffering model. GO annotations related to this gene include oxidative phosphorylation uncoupler activity. An important paralog of this gene is UCP3.

UniProtKB/Swiss-Prot: UCP1_HUMAN, P25874

Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane,

thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Gene Wiki entry for UCP1 (Thermogenin) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NT_016354.19 NC_018915.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UCP1 gene promoter:
ATF-2 NF-AT HNF-4alpha1 CREB CRE-BP1 NF-AT2 POU2F1 deltaCREB POU2F1a NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UCP1 promoter sequence

Search SABiosciences Chromatin IP Primers for UCP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28-q31 Ensembl cytogenetic band: 4q31.1 HGNC cytogenetic band: 4q28-q31

UCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCP1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M141480: view genomic region (about GC identifiers)

Start:	141,480,588 bp from pter	End:	141,489,959 bp from pter
Size:	9,372 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCP1_HUMAN, P25874 (See protein sequence)

Recommended Name: Mitochondrial brown fat uncoupling protein 1

Size: 307 amino acids; 33005 Da

Subunit: Acts as a dimer forming a proton channel

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Secondary accessions: Q13218 Q4KMZ3 Q68G66

Explore the universe of human proteins at neXtProt for UCP1: NX_P25874

Explore proteomics data for UCP1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P25874

UCP1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_068605.1

ENSEMBL proteins:

ENSP00000262999

Reactome Protein details: P25874
Human Recombinant Protein Products for UCP1:

	EMD Millipore Purified and/or Recombinant UCP1 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for UCP1 OriGene Custom MassSpec OriGene Custom Protein Services for UCP1
	GenScript Custom Purified and Recombinant Proteins Services for UCP1
	Novus Biologicals UCP1 Protein Novus Biologicals UCP1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for UCP1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	9054939
GO:0005740	mitochondrial envelope	--	--
GO:0005743	mitochondrial inner membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

UCP1 for ontologies About GeneDecksing

UCP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of UCP1
	R&D Systems Antibodies for UCP1
	OriGene Antibodies for UCP1 OriGene Custom Antibody Services for UCP1
	GenScript Custom Superior Antibodies Services for UCP1
	Novus Biologicals UCP1 Antibodies
	Abcam antibodies for UCP1
	Cloud-Clone Corp. Antibodies for UCP1
	ThermoFisher Antibodies for UCP1
	LSBio Antibodies in human, mouse, rat for UCP1

Assay Products for UCP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for UCP1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for UCP1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for UCP1 Cloud-Clone Corp. CLIAs for UCP1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Uncoupling protein 1

Mitochondrial uncoupling proteins

3 InterPro protein domains:

IPR023395 Mt_carrier_dom

IPR002030 Mit_uncoupling

IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry P25874

ProtoNet protein and cluster: P25874

1 Blocks protein domain: IPB002030 Mitochondrial brown fat uncoupling protein signature

UniProtKB/Swiss-Prot: UCP1_HUMAN, P25874

Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family

Similarity: Contains 3 Solcar repeats

UCP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: UCP1_HUMAN, P25874

Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane,

thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Genatlas biochemistry entry for UCP1:

uncoupling protein of inner mitochondrial membrane 1,dissipating the proton electrochemical gradient and uncoupling

fuel oxidation from ADP-ATP conversion,expressed in brown adipose tissue,regulated by PPARA and PPARG in mice,with a

minor role of the 5'utr polymorphism in obesity and diabetes

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0017077	oxidative phosphorylation uncoupler activity	IEA	--

UCP1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for UCP1:

Decreased viability of wild-ty

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ucp1):

adipose tissue	behavior/neurological	cardiovascular system	cellular	growth/size
homeostasis/metabolism	other	vision/eye

UCP1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ucp1^tm1Kz for UCP1

inGenious Targeting Laboratory - Custom generated mouse model solutions for UCP1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCP1

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCP1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UCP1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for UCP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against UCP1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for UCP1
			Sirion Biotech Customized adenovirus for overexpression of UCP1 Customized adenovirus for potent knockdown of UCP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for UCP1 (see all 6) OriGene ORF clones in mouse, rat for UCP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: UCP1 (NM_021833)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for UCP1
		Search LifeMap BioReagents cell lines for UCP1
		Sirion Biotech Customized stable knockdown cell line services for UCP1 Customized inducible knockdown cell line services for UCP1 Customized stable overexpressing cell line services for UCP1 Customized inducible overexpressing cell line services for UCP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for UCP1 About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	0.81			The citric acid (TCA) cycle and respiratory electron transport	0.72
	Electron Transport Chain	0.75			Huntington's disease	0.47

The fatty acid cycling model

	Mitochondrial Uncoupling Proteins	1.00			The fatty acid cycling model	1.00
	The proton buffering model	1.00

Metabolism

Metabolism

0.40

PKA activation in glucagon signalling

Development Beta-adrenergic receptors signaling via cAMP

0.32

PPAR signaling pathway

PPAR signaling pathway

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for UCP1

Development Beta-adrenergic receptors signaling via cAMP

1 GeneGo (Thomson Reuters) Pathway for UCP1

Development Beta-adrenergic receptors signaling via cAMP

2 BioSystems Pathways for UCP1

	Adipogenesis
	Electron Transport Chain

5/6 Reactome Pathways for UCP1 (see all 6)

	The proton buffering model
	Mitochondrial Uncoupling Proteins
	Metabolism
	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
	The citric acid (TCA) cycle and respiratory electron transport

2 Kegg Pathways (Kegg details for UCP1):

	PPAR signaling pathway
	Huntington's disease

UCP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UCP1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for UCP1 (P25874³ ENSP00000262999⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TOMM20	Q15388³, ENSP00000355566⁴	I2D: score=2 STRING: ENSP00000355566
CIDEA	O60543³	I2D: score=1
UCP2	ENSP00000312029⁴	STRING: ENSP00000312029
--	ENSP00000339344⁴	STRING: ENSP00000339344

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006839	mitochondrial transport	IEA	--
GO:0015992	proton transport	TAS	--
GO:0022904	respiratory electron transport chain	TAS	--
GO:0044237	cellular metabolic process	TAS	--

UCP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UCP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UCP1

10/62 Novoseek inferred chemical compound relationships for UCP1 gene (see all 62) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pgc1	73.4	2	18287225 (1), 10585775 (1)
fatty acid	67.9	61	11468281 (3), 8626410 (3), 11004454 (3), 12807871 (2) (see all 33)
atp	63.5	62	12734183 (4), 16180337 (3), 1756853 (2), 8132485 (2) (see all 41)
hydrogen	57.5	65	11468281 (3), 10736318 (2), 10868929 (2), 11721329 (2) (see all 42)
gdp	57.2	17	9813009 (1), 9271366 (1), 9562032 (1), 10622736 (1) (see all 13)
carboxyatractyloside	55.7	3	1420170 (1), 15146050 (1)
glucose	54.3	47	19833897 (2), 17873137 (2), 18593740 (2), 20338842 (2) (see all 26)
adp	50.5	12	1756853 (2), 8132485 (2), 9813009 (1), 11171965 (1) (see all 8)
lipid	49.9	34	11870545 (4), 12475182 (3), 12753942 (2), 17242157 (2) (see all 20)
3,3'-dihexyloxacarbocyanine iodide	48.6	1	11285367 (1)

Search CenterWatch for drugs/clinical trials and news about UCP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UCP1 gene:

NM_021833.4

Unigene Cluster for UCP1:

Uncoupling protein 1 (mitochondrial, proton carrier)

Hs.249211 [show with all ESTs]

Unigene Representative Sequence: BC098258

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000262999(uc011chj.2 uc011chk.2)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCP1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UCP1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for UCP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against UCP1

Clone Products:		OriGene clones in human, mouse for UCP1 (see all 6) OriGene ORF clones in mouse, rat for UCP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: UCP1 (NM_021833)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCP1

Primer Products:		OriGene qPCR primer pairs and template standards for UCP1 OriGene qSTAR qPCR primer pairs in human, mouse for UCP1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat UCP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCP1

Additional mRNA sequence:

BC069556.1 BC096736.1 BC098168.1 BC098258.1 BC098352.1 U28480.1

1 DOTS entry:

DT.405464

4 AceView cDNA sequences:

BC069556 NM_021833 U28480 BG203995

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for UCP1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6
SP1:
SP2:

ECgene alternative splicing isoforms for UCP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UCP1 expression in normal human tissues (normalized intensities) UCP1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

UCP1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/4 selected tissues (see all 4) fully expand


Adipose (Muscoskeletal System) fully expand to see all 23 entries
Sacral Brown Adipocyte Cells Sacral Brown Adipose Depot
Body Subcutaneous White Adipose
Brown adipocyte-like cells (Differentiation of white and brown adipocytes from human...

Breast
mammary gland

Endothelium (Cardiovascular System)
aorta

Kidney (Urinary System)

See UCP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCP1

SOURCE GeneReport for Unigene cluster: Hs.249211

UniProtKB/Swiss-Prot: UCP1_HUMAN, P25874

Tissue specificity: Brown adipose tissue

SABiosciences Expression via Pathway-Focused PCR Arrays including UCP1 (see all 11):

Insulin Signaling Pathway in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Mitochondrial Energy Metabolism in human mouse rat

Cardiotoxicity in human mouse rat

Adipogenesis in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for UCP1 OriGene qSTAR qPCR primer pairs in human, mouse for UCP1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat UCP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for UCP1 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ucp1^{1 , 5}	uncoupling protein 1 (mitochondrial, proton carrier)^{1, 5}	79.98(n)¹ 79.87(a)¹		8 (39.65 cM)⁵ 22227¹ NM_009463.3¹ NP_033489.1¹ 83290348⁵
lizard (Anolis carolinensis)	Reptilia	UCP3⁶	Uncharacterized protein	56(a)	1 ↔ 1	GL343978.1(51675-84185)
zebrafish (Danio rerio)	Actinopterygii	ucp1⁶ ucp3⁶	uncoupling protein 3	61(a) 54(a)	1 ↔ 1 possible ortholog	1(53870145-53884605) 10(37894303-37900774)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	DIC1⁶	Mitochondrial dicarboxylate carrier, integral memb...	29(a)	1 → many	XII(826977-827873)

ENSEMBL Gene Tree for UCP1 (if available)
TreeFam Gene Tree for UCP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UCP1 gene

UCP3² UCP2² SLC25A14² SLC25A11² ENSG00000262660² SLC25A10² SLC25A30² SLC25A27²

9 SIMAP similar genes for UCP1 using alignment to 2 protein entries: UCP1_HUMAN (see all proteins):

UCP2 SLC25A10 SLC25A14 SLC25A27 SLC25A11 UCP3

SLC25A30 SLC25A34 SLC25A35

UCP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: UCP1_HUMAN, P25874

Polymorphism: The Thr-64 polymorphism is associated with an increased waist-to-hip ratio. The Leu-229 polymorphism is

associated with susceptibility to type II diabetes mellitus

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5862487^1,2	C	--	137212355(+)	`GCTGC-/A/A A/AAAAAAAA`	2	--	int¹ cds¹ trp³		1		CSA	2
rs112019388^1,2	C	--	137215219(+)	`TTGTA-/TTTTTT`	1	--	int¹		1		CSA	2
rs36202338^1,2	C	--	137219716(+)	`CTACCGTGTGT GTGT/-GTGTG`	1	--	int¹		1		CSA	2
rs147701972^1,2		--	141264991(+)	`CTCTTA/GCACCC`	1	--	ds500¹		0	--	--	--	--
rs79001246^1,2	C,F	--	141265437(+)	`ATGATC/ACAGTC`	1	--	ds500¹		1		WA	118
rs146114327^1,2	C,F	--	141265588(+)	`CAAGAA/GGGAAG`	2	L F	mis¹		1		NA	4550
rs142145526^1,2	C	--	141265622(+)	`TCATCA/GTTCGA`	1	--	int¹		0	--	--	--	--
rs117949489^1,2	C,F	--	141265683(+)	`CTGCCG/ACCCAG`	1	--	int¹		1		EA	120
rs145918476^1,2		--	141265725(+)	`TGCAAC/TCTCGA`	1	--	int¹		0	--	--	--	--
rs78724285^1,2	F	--	141265957(+)	`CAACAC/TAGCCC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for UCP1 (141480588 - 141489959 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for UCP1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv880165	CNV	Loss	21882294
nsv830088	CNV	Gain	17160897

Human Gene Mutation Database (HGMD): UCP1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UCP1

DNA2.0 Custom Variant and Variant Library Synthesis for UCP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UCP1 for disorders           About GeneDecksing

OMIM gene information: 113730
OMIM disorders: 601665
20/38 diseases for UCP1 (see all 38):    About MalaCards

multiple symmetric lipomatosis multiple symmetrical lipomatosis lipomatosis morbid obesity

sudden infant death syndrome diabetic neuropathy familial combined hyperlipidemia lipoma

obesity, association with insulinoma metabolic disorders spinal cord injury

insulin resistance lipodystrophy obesity pheochromocytoma

cleft lip diabetes mellitus anorexia nervosa hyperglycemia

2 diseases from the University of Copenhagen DISEASES database for UCP1:

Diabetes mellitus Lipomatosis

10/21 Novoseek inferred disease relationships for UCP1 gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	73.7	105	10753048 (3), 11484071 (3), 10702757 (3), 11093283 (3) (see all 53)
hibernoma	58.9	2	8468458 (1), 8054887 (1)
lipomatosis, multiple symmetric	52.2	2	11095987 (1)
insulin resistance	51.8	6	10999801 (2), 16034720 (1), 17397545 (1), 10337866 (1)
insulin sensitivity	48.4	6	18059082 (2), 9398715 (1), 19136989 (1), 17531095 (1)
metabolic disorder	38.7	8	10395193 (1), 19946892 (1), 15281018 (1), 10469165 (1) (see all 6)
niddm	36.2	13	1959481 (2), 11484071 (1), 10403804 (1), 16338218 (1) (see all 6)
sudden infant death syndrome	7.94	3	12029453 (2), 1584092 (1)
lipoma	4.76	4	11095987 (2), 8468458 (1)
cancer	4.29	16	8033632 (4), 18780286 (3), 16904608 (2), 9389065 (2) (see all 7)

Genetic Association Database (GAD): UCP1
Human Genome Epidemiology (HuGE) Navigator: UCP1 (60 documents)

Export disorders for UCP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UCP1 gene, integrated from 9 sources (see all 474):
(articles sorted by number of sources associating them with UCP1)

Utopia: connect your pdf to the dynamic
world of online information

Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4. (PubMed id 2380264)^{1, 2, 3, 9} Cassard A.M.... Ricquier D. (1990)
Uncoupling protein 1 and 3 polymorphisms are associated with waist- to-hip ratio. (PubMed id 12756473)^{1, 2, 4, 9} Herrmann S.M.... Brand E. (2003)
A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus. (PubMed id 11317671)^{1, 2, 4} Mori H.... Kasuga M. (2001)
The effects of uncoupling protein-1 genotype on lipoprotein cholesterol level in Korean obese subjects. (PubMed id 15281018)^{1, 4, 9} Oh H.H....Yoon Y. (2004)
The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. (PubMed id 17397545)^{1, 4, 9} Sale M.M....Norris J.M. (2007)
Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity. (PubMed id 11439286)^{1, 4, 9} Shihara N....Tsuda K. (2001)
Association of UCP1 genetic polymorphisms with blood pressure among Korean female subjects. (PubMed id 18955781)^{1, 4, 9} Cha M.H....Yoon Y. (2008)
Sudden infant death: no evidence for linkage to common polymorphisms in the uncoupling protein-1 and the beta3-adrenergic receptor genes. (PubMed id 12029453)^{1, 4, 9} Fatemi A....Strobl W. (2002)
A haplotype at the UCP1 gene locus contributes to gen etic risk for type 2 diabetes in Asian Indians (CURES-72). (PubMed id 19943796)^{1, 4, 9} Vimaleswaran K.S....Mohan V. (2010)
Absence of Association of Metabolic Syndrome with PPARGC1A, PPARG and UCP1 Gene Polymorphisms in Asian Indians. (PubMed id 18370824)^{1, 4, 9} Vimaleswaran K.S....Mohan V. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7350	HGNC: 12517	AceView: UCP1	Ensembl:ENSG00000109424	euGenes: HUgn7350
ECgene: UCP1	Kegg: 7350	H-InvDB: UCP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UCP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UCP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for UCP1 gene:
Search GeneIP for patents involving UCP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of UCP1
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	EMD Millipore Purified and/or Recombinant UCP1 Protein

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for UCP1 (UCP1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for UCP1		OriGene RNAi products in human, mouse, rat for UCP1
	OriGene qPCR primer pairs and template standards for UCP1		OriGene Protein Over-expression Lysate for UCP1
	OriGene Custom Mass Spec		OriGene clones in human, mouse for UCP1
	OriGene qSTAR qPCR primer pairs in human, mouse for UCP1		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for UCP1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for UCP1		OriGene Custom Protein Services for UCP1

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UCP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UCP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCP1

	GenScript Custom Purified and Recombinant Proteins Services for UCP1		GenScript cDNA clones with any tag delivered in your preferred vector for UCP1
	GenScript Custom Assay Services for UCP1		GenScript Custom Superior Antibodies Services for UCP1
	GenScript Custom overexpressing Cell Line Services for UCP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in UCP1 promoter
	Search Chromatin IP Primers for UCP1
	RT² qPCR Primer Assay in human, mouse, rat UCP1
	GNC Network for UCP1
	SABiosciences PCR Arrays including human, mouse, rat UCP1

Search Tocris compounds for UCP1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	UCP1 antibodies
	UCP1 proteins
	UCP1 lysates

	Antibodies for UCP1
	See all of Abcam's Antibodies, Kits and Proteins for UCP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for UCP1
	Antibodies for UCP1
	ELISAs for UCP1
	CLIAs for UCP1

Search LifeMap BioReagents cell lines for UCP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCP1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for UCP1
	SwitchGear Promoter luciferase reporter plasmids for UCP1

ThermoFisher Antibodies for UCP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCP1

	inGenious Targeting Laboratory - Custom generated mouse model solutions for UCP1
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCP1

Customized:

	stable knockdown cell line services for UCP1
	inducible knockdown cell line services for UCP1
	design and validation of potent shRNA sequences against UCP1
	adenovirus for potent knockdown of UCP1
	stable overexpressing cell line services for UCP1
	inducible overexpressing cell line services for UCP1
	adenovirus for overexpression of UCP1

LSBio Antibodies in human, mouse, rat for UCP1

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes UCP1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

UCP1 Gene

Uncoupling Protein 1 (Mitochondrial, Proton Carrier)

Aliases
for UCP1 gene

Summaries
for UCP1 gene

Genomic Views
for UCP1 gene

Proteins
for UCP1 gene

Protein Domains /
Families
for UCP1 gene

Function
for UCP1 gene

Pathways & Interactions
for UCP1 gene

Drugs & Compounds
for UCP1 gene

Transcripts
for UCP1 gene

Expression
for UCP1 gene

Orthologs
for UCP1 gene

Paralogs
for UCP1 gene

Genomic Variants
for UCP1 gene

Disorders / Diseases
for UCP1 gene

Publications
for UCP1 gene

External Searches for UCP1 gene

Genome Databases showing UCP1 gene

Other Databases showing UCP1 gene

Specialized Databases showing UCP1 gene

Intellectual Property
for UCP1 gene

Products
for UCP1 gene

View Random Gene

Lipoma
Insulin Resistance
Inflammation
Diabetic Nephropathies
Hibernoma
OBESITY
LIPOMATOSIS, MULTIPLE SYMMETRIC
Insulinoma
Sudden infant death syndrome
Hyperlipidemia
Hypertrophy
insulin sensitivity
Diabetes Mellitus
Atherosclerosis
Tumors
Pheochromocytoma
Necrosis
metabolic disorder
NIDDM
Cancer
Diabetes Mellitus Insulin-Dependent

Advanced Search

Export list of displayed genes

UCP1 Gene

Uncoupling Protein 1 (Mitochondrial, Proton Carrier)

Aliasesfor UCP1 gene

Summariesfor UCP1 gene

Genomic Viewsfor UCP1 gene

Proteinsfor UCP1 gene

Protein Domains /Familiesfor UCP1 gene

Functionfor UCP1 gene

Pathways & Interactionsfor UCP1 gene

Drugs & Compoundsfor UCP1 gene

Transcriptsfor UCP1 gene

Expression for UCP1 gene

Orthologsfor UCP1 gene

Paralogsfor UCP1 gene

Genomic Variantsfor UCP1 gene

Disorders / Diseasesfor UCP1 gene

Publicationsfor UCP1 gene

External Searches for UCP1 gene

Genome Databases showing UCP1 gene

Other Databases showing UCP1 gene

Specialized Databases showing UCP1 gene

Intellectual Propertyfor UCP1 gene

Productsfor UCP1 gene

View Random Gene

Aliases
for UCP1 gene

Summaries
for UCP1 gene

Genomic Views
for UCP1 gene

Proteins
for UCP1 gene

Protein Domains /
Families
for UCP1 gene

Function
for UCP1 gene

Pathways & Interactions
for UCP1 gene

Drugs & Compounds
for UCP1 gene

Transcripts
for UCP1 gene

Expression
for UCP1 gene

Orthologs
for UCP1 gene

Paralogs
for UCP1 gene

Genomic Variants
for UCP1 gene

Disorders / Diseases
for UCP1 gene

Publications
for UCP1 gene

Intellectual Property
for UCP1 gene

Products
for UCP1 gene