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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCN3 Gene

protein-coding   GIFtS: 50
GCID: GC10P005396

Urocortin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Urocortin 31 2     SPC2 3
Prepro-Urocortin 31 2     SCP2
stresscopin1 2     UCNIII2
Ucn III2 3     urocortin-32
Urocortin III2 3     Stresscopin3

External Ids:    HGNC: 177811   Entrez Gene: 1141312   Ensembl: ENSG000001784737   OMIM: 6059015   UniProtKB: Q969E33   

Export aliases for UCN3 gene to outside databases

Previous GC identifer: GC10P005369


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCN3 Gene:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally
related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF
type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene
family name similarity, the product of this gene has no sequence similarity to urotensin II. (provided by RefSeq,
Jul 2008)

GeneCards Summary for UCN3 Gene: 
UCN3 (urocortin 3) is a protein-coding gene. Diseases associated with UCN3 include sleep apnea, and major depressive disorder, and among its related super-pathways are G-Beta Gamma Signaling. GO annotations related to this gene include corticotropin-releasing hormone receptor 2 binding and hormone activity.

UniProtKB/Swiss-Prot: UCN3_HUMAN, Q969E3
Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an
endogenous ligand for maintaining homeostasis after stress

Gene Wiki entry for UCN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCN3 gene promoter:
         Nkx3-1   FOXF2   Cdc5   POU3F2   NF-AT   Evi-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

UCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCN3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P005396:  view genomic region     (about GC identifiers)

Start:
5,406,972 bp from pter      End:
5,416,169 bp from pter
Size:
9,198 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCN3_HUMAN, Q969E3 (See protein sequence)
Recommended Name: Urocortin-3 precursor  
Size: 161 amino acids; 17961 Da
Subunit: Binds with high affinity to CRF receptors 2-alpha and 2-beta
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for UCN3:
2RMH (3D)        3N93 (3D)    
Secondary accessions: Q496H2 Q5SR91

Explore the universe of human proteins at neXtProt for UCN3: NX_Q969E3

Explore proteomics data for UCN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969E3

  • UCN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UCN3 Protein Expression
    REFSEQ proteins: NP_444277.2  
    ENSEMBL proteins: 
     ENSP00000369798  

    Human Recombinant Protein Products for UCN3: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for UCN3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0030424axon ----
    GO:0043005neuron projection ----
    GO:0043196varicosity IEA--
    GO:0043679axon terminus IEA--

    UCN3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR024270 Urocortin_II/III

    Graphical View of Domain Structure for InterPro Entry Q969E3

    ProtoNet protein and cluster: Q969E3

    UniProtKB/Swiss-Prot: UCN3_HUMAN, Q969E3
    Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


    UCN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCN3_HUMAN, Q969E3
    Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an
    endogenous ligand for maintaining homeostasis after stress

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0005515protein binding ----
    GO:0051431corticotropin-releasing hormone receptor 2 binding IEA--
         
    UCN3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ucn3):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system  nervous system 

    UCN3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ucn3tm1Pbl for UCN3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UCN3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCN3 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UCN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-Beta Gamma Signaling
    CRHR Pathway0.44
    2Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
    Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for UCN3
        CRHR Pathway


    1 PharmGKB Pathway for UCN3
        Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UCN3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for UCN3 (Q969E33 ENSP000003697984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL10RBQ083343, ENSP000002902004I2D: score=2 STRING: ENSP00000290200
    CRHR1P349983, ENSP000003813334I2D: score=1 STRING: ENSP00000381333
    CRHR2Q133243I2D: score=1 
    --ENSP000002228364STRING: ENSP00000222836
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress ----
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007586digestion IEA--
    GO:0009749response to glucose stimulus IEA--
    GO:0031669cellular response to nutrient levels IEA--

    UCN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UCN3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCN3

    6 Novoseek inferred chemical compound relationships for UCN3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 83.2 1 18052377 (1)
    astressin 81.1 1 12970166 (1)
    acth 33.1 3 16626608 (2), 15165722 (1)
    adenylate 29.5 2 12401516 (1), 12746280 (1)
    nitric oxide 0 3 11854458 (2), 15784708 (1)
    glucose 0 2 12810578 (1), 18337115 (1)

    Search CenterWatch for drugs/clinical trials and news about UCN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UCN3 gene: 
    NM_053049.2  

    Unigene Cluster for UCN3:

    Urocortin 3
    Hs.511775  [show with all ESTs]
    Unigene Representative Sequence: NM_053049
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380433(uc001ihx.1)
    miRNA
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    Additional mRNA sequence: 

    AY026949.1 BC069530.1 BC100867.2 BC100868.1 BC100869.1 BC100870.1 

    1 DOTS entry:

    DT.97835590 

    12 AceView cDNA sequences:

    BQ776556 BQ270989 BM310655 BM310953 NM_053049 AW293249 BC069530 BQ778217 
    BQ776877 AY026949 BQ777111 CA950349 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCN3 expression in normal human tissues (normalized intensities)      UCN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTCCTCT
    UCN3 Expression
    About this image


    UCN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)
             Dorsal Horn   
     
     Pancreas (Endocrine System)

    See UCN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCN3

    SOURCE GeneReport for Unigene cluster: Hs.511775
        SABiosciences Custom PCR Arrays for UCN3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UCN3 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ucn31 , 5 urocortin 31, 5 75.42(n)1
    66.25(a)1
      13 (2.20 cM)5
    834281  NM_031250.51  NP_112540.21 
     39406885 
    chicken
    (Gallus gallus)
    Aves UCN31 urocortin 3 (stresscopin) 69.09(n)
    62.25(a)
      769274  XM_001231710.1  XP_001231711.1 
    lizard
    (Anolis carolinensis)
    Reptilia UCN36
    Uncharacterized protein
    53(a)
    1 ↔ 1
    5(3754592-3755056)
    zebrafish
    (Danio rerio)
    Actinopterygii ucn3l1 urocortin 3, like 59.34(n)
    50.35(a)
      100003848  NM_001082954.2  NP_001076423.1 


    ENSEMBL Gene Tree for UCN3 (if available)
    TreeFam Gene Tree for UCN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/470 SNPs in UCN3 are shown (see all 470)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107952671,2
    C,F,A--5404983(+) ATGAAC/TGAATG 1 -- us2k111Minor allele frequency- T:0.38NA WA CSA EA 372
    rs760926561,2
    --5404991(+) ATGAAG/TGAACT 1 -- us2k10--------
    rs1119354971,2
    C--5405012(+) GAACT-/AATG/ 
    AATGAATG
    AATGA
    1 -- us2k11CSA 2
    rs667643951,2
    C--5405013(+) AACTA-/AATG  
            
    ATGAA
    1 -- us2k10--------
    rs750206441,2
    C--5405014(+) ATGAA-/TGAA  
            
    CTAAT
    1 -- us2k10--------
    rs1170897501,2
    F--5405048(+) TGAATG/CAATGA 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1919320901,2
    --5405050(+) AATGAA/CTGAAG 1 -- us2k10--------
    rs1476189411,2
    --5405063(+) ATGAAC/TTTGAA 1 -- us2k10--------
    rs1408476641,2
    --5405110(+) TCAAGA/GGGATC 1 -- us2k10--------
    rs1841328411,2
    --5405256(+) ATGGGC/TTTTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UCN3 (5406972 - 5416169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UCN3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669711CNV Deletion23128226
    esv2660343CNV Deletion23128226
    nsv894783CNV Loss21882294
    nsv894792CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605901    OMIM disorders: --

    14 diseases for UCN3:    About MalaCards
    sleep apnea    major depressive disorder    irritable bowel syndrome    pheochromocytoma
    alcohol dependence    lung adenocarcinoma    hypoxia    endometriosis
    alcoholism    osteoarthritis    adenocarcinoma    endotheliitis
    pancreatitis    neuronitis


    UCN3 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for UCN3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adrenal tumor 42.9 4 16095756 (2), 15914529 (1)
    pheochromocytoma 19 3 16095756 (2), 15914529 (1)
    tumors 0 2 16095756 (1), 15914529 (1)
    obesity 0 1 17183713 (1)
    heart failure 0 1 15320806 (1)

    Genetic Association Database (GAD): UCN3
    Human Genome Epidemiology (HuGE) Navigator: UCN3 (3 documents)

    Export disorders for UCN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCN3 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with UCN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. (PubMed id 11416224)1, 2, 3, 9 Lewis K.... Vale W.W. (2001)
    2. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PubMed id 11329063)1, 2, 9 Hsu S.Y. and Hsueh A.J.W. (2001)
    3. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PubMed id 18504423)1, 4 Wong M.L....Licinio J. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Expression of urocortin III/stresscopin in human heart and kidney. (PubMed id 15070962)1, 9 Takahashi K....Shibahara S. (2004)
    6. Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors. (PubMed id 16095756)1, 9 Takahashi K....Murakami O. (2006)
    7. Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. (PubMed id 16626608)1, 9 Imperatore A....Petraglia F. (2006)
    8. Suppression of progesterone production by stresscopin /urocortin 3 in cultured human granulosa-lutein cells. (PubMed id 19351656)1, 9 Yata A....Maruo T. (2009)
    9. Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions. (PubMed id 15949638)1, 9 Saruta M....Sasano H. (2005)
    10. Ancient evolution of stress-regulating peptides in vertebrates. (PubMed id 15476935)1, 9 Chang C.L. and Hsu S.Y. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114131 HGNC: 17781 AceView: UCN3 Ensembl:ENSG00000178473 euGenes: HUgn114131
    ECgene: UCN3 H-InvDB: UCN3

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for UCN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for UCN3 gene:
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