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Aliases for UCN3 Gene

Aliases for UCN3 Gene

  • Urocortin 3 2 3
  • Stresscopin 2 3 4
  • Prepro-Urocortin 3 2 3
  • Urocortin III 3 4
  • Ucn III 3 4
  • SPC 3 4
  • Urocortin-3 3
  • UCNIII 3
  • SCP 3

External Ids for UCN3 Gene

Previous GeneCards Identifiers for UCN3 Gene

  • GC10P005369

Summaries for UCN3 Gene

Entrez Gene Summary for UCN3 Gene

  • This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCN3 Gene

UCN3 (Urocortin 3) is a Protein Coding gene. Diseases associated with UCN3 include pheochromocytoma. Among its related pathways are G-Beta Gamma Signaling and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. GO annotations related to this gene include hormone activity and corticotropin-releasing hormone receptor 2 binding.

UniProtKB/Swiss-Prot for UCN3 Gene

  • Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress

Gene Wiki entry for UCN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCN3 Gene

Genomics for UCN3 Gene

Regulatory Elements for UCN3 Gene

Genomic Location for UCN3 Gene

Start:
5,365,009 bp from pter
End:
5,374,692 bp from pter
Size:
9,684 bases
Orientation:
Plus strand

Genomic View for UCN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCN3 Gene

Proteins for UCN3 Gene

  • Protein details for UCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969E3-UCN3_HUMAN
    Recommended name:
    Urocortin-3
    Protein Accession:
    Q969E3
    Secondary Accessions:
    • Q496H2
    • Q5SR91

    Protein attributes for UCN3 Gene

    Size:
    161 amino acids
    Molecular mass:
    17961 Da
    Quaternary structure:
    • Binds with high affinity to CRF receptors 2-alpha and 2-beta.

    Three dimensional structures from OCA and Proteopedia for UCN3 Gene

neXtProt entry for UCN3 Gene

Proteomics data for UCN3 Gene at MOPED

Post-translational modifications for UCN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UCN3 Gene

Domains for UCN3 Gene

Gene Families for UCN3 Gene

HGNC:

Protein Domains for UCN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UCN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969E3

UniProtKB/Swiss-Prot:

UCN3_HUMAN :
  • Q969E3
Family:
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with UCN3: view

Function for UCN3 Gene

Molecular function for UCN3 Gene

UniProtKB/Swiss-Prot Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress

Gene Ontology (GO) - Molecular Function for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005179 hormone activity IEA --
GO:0005515 protein binding --
GO:0051431 corticotropin-releasing hormone receptor 2 binding IEA --
genes like me logo Genes that share ontologies with UCN3: view
genes like me logo Genes that share phenotypes with UCN3: view

Animal Models for UCN3 Gene

MGI Knock Outs for UCN3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for UCN3 Gene

Localization for UCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCN3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCN3 Gene COMPARTMENTS Subcellular localization image for UCN3 gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0030424 axon --
GO:0043005 neuron projection --
GO:0043196 varicosity IEA --
GO:0043679 axon terminus IEA --
genes like me logo Genes that share ontologies with UCN3: view

Pathways for UCN3 Gene

genes like me logo Genes that share pathways with UCN3: view

Pathways by source for UCN3 Gene

1 Qiagen pathway for UCN3 Gene
1 PharmGKB pathway for UCN3 Gene

Interacting Proteins for UCN3 Gene

Gene Ontology (GO) - Biological Process for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007586 digestion IEA --
GO:0009749 response to glucose IEA --
GO:0031669 cellular response to nutrient levels IBA --
genes like me logo Genes that share ontologies with UCN3: view

Compounds for UCN3 Gene

(6) Novoseek inferred chemical compound relationships for UCN3 Gene

Compound -log(P) Hits PubMed IDs
sauvagine 83.2 1
astressin 81.1 1
acth 33.1 3
adenylate 29.5 2
nitric oxide 0 3
genes like me logo Genes that share compounds with UCN3: view

Transcripts for UCN3 Gene

mRNA/cDNA for UCN3 Gene

(12) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCN3 Gene

Urocortin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCN3 Gene

No ASD Table

Relevant External Links for UCN3 Gene

GeneLoc Exon Structure for
UCN3
ECgene alternative splicing isoforms for
UCN3

Expression for UCN3 Gene

mRNA expression in normal human tissues for UCN3 Gene

mRNA differential expression in normal tissues according to GTEx for UCN3 Gene

This gene is overexpressed in Pancreas (12.7), Pituitary (11.9), Colon - Transverse (8.4), and Small Intestine - Terminal Ileum (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UCN3 Gene

SOURCE GeneReport for Unigene cluster for UCN3 Gene Hs.511775

genes like me logo Genes that share expressions with UCN3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UCN3 Gene

Orthologs for UCN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UCN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCN3 35
  • 99.17 (n)
  • 98.76 (a)
UCN3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UCN3 35
  • 75.98 (n)
  • 65.22 (a)
UCN3 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCN3 35
  • 77.43 (n)
  • 67.08 (a)
UCN3 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ucn3 35
  • 74.33 (n)
  • 64.6 (a)
Ucn3 16
Ucn3 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UCN3 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ucn3 35
  • 76.6 (n)
  • 66.46 (a)
chicken
(Gallus gallus)
Aves UCN3 35
  • 70.8 (n)
  • 64.34 (a)
lizard
(Anolis carolinensis)
Reptilia UCN3 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488336 35
  • 62.69 (n)
  • 61.19 (a)
zebrafish
(Danio rerio)
Actinopterygii ucn3l 35
  • 59.4 (n)
  • 48.12 (a)
ucn3l 36
  • 49 (a)
OneToOne
Species with no ortholog for UCN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCN3 Gene

ENSEMBL:
Gene Tree for UCN3 (if available)
TreeFam:
Gene Tree for UCN3 (if available)

Paralogs for UCN3 Gene

No data available for Paralogs for UCN3 Gene

Variants for UCN3 Gene

Sequence variations from dbSNP and Humsavar for UCN3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4075424 -- 5,372,735(+) ttttt(G/T)tgtag intron-variant
rs6601952 -- 5,371,671(+) TGAGC(A/C)CCGAC intron-variant
rs6601953 -- 5,371,819(+) CTAAC(A/G)TAAGA intron-variant
rs7068585 -- 5,364,065(+) cgcct(C/T)ggcct upstream-variant-2KB
rs7082407 -- 5,372,616(+) acaat(C/G)acagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCN3 Gene

Variant ID Type Subtype PubMed ID
nsv894783 CNV Loss 21882294
nsv894792 CNV Gain 21882294
esv2660343 CNV Deletion 23128226
esv2669711 CNV Deletion 23128226

Relevant External Links for UCN3 Gene

HapMap Linkage Disequilibrium report
UCN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCN3 Gene

Disorders for UCN3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UCN3 Gene including...

Search for UCN3 Gene in MalaCards »

(5) Novoseek inferred disease relationships for UCN3 Gene

Disease -log(P) Hits PubMed IDs
adrenal tumor 42.9 3
pheochromocytoma 19 3
tumors 0 2
obesity 0 1
heart failure 0 1

Relevant External Links for UCN3

Genetic Association Database (GAD)
UCN3
Human Genome Epidemiology (HuGE) Navigator
UCN3
genes like me logo Genes that share disorders with UCN3: view

No data available for UniProtKB/Swiss-Prot for UCN3 Gene

Publications for UCN3 Gene

  1. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. (PMID: 11416224) Lewis K. … Vale W.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PMID: 11329063) Hsu S.Y. … Hsueh A.J.W. (Nat. Med. 2001) 3 4 23
  3. Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. (PMID: 16626608) Imperatore A. … Petraglia F. (Am. J. Obstet. Gynecol. 2006) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human endometrium expresses urocortin II and III messenger RNA and peptides. (PMID: 17074339) Florio P. … Petraglia F. (Fertil. Steril. 2006) 3 23

Products for UCN3 Gene

Sources for UCN3 Gene

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