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UCN3 Gene

protein-coding   GIFtS: 49
GCID: GC10P005396

Urocortin 3

  See UCN3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Urocortin 31 2     SPC2 3
Prepro-Urocortin 31 2     SCP2
stresscopin1 2     UCNIII2
Ucn III2 3     urocortin-32
Urocortin III2 3     Stresscopin3

External Ids:    HGNC: 177811   Entrez Gene: 1141312   Ensembl: ENSG000001784737   OMIM: 6059015   UniProtKB: Q969E33   

Export aliases for UCN3 gene to outside databases

Previous GC identifer: GC10P005369


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UCN3 Gene:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally
related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF
type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene
family name similarity, the product of this gene has no sequence similarity to urotensin II. (provided by RefSeq,
Jul 2008)

GeneCards Summary for UCN3 Gene:
UCN3 (urocortin 3) is a protein-coding gene. Diseases associated with UCN3 include pheochromocytoma. GO annotations related to this gene include corticotropin-releasing hormone receptor 2 binding and hormone activity.

UniProtKB/Swiss-Prot: UCN3_HUMAN, Q969E3
Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an
endogenous ligand for maintaining homeostasis after stress

Gene Wiki entry for UCN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UCN3 gene promoter:
         Nkx3-1   FOXF2   Cdc5   POU3F2   NF-AT   Evi-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCN3 promoter sequence
   Search Chromatin IP Primers for UCN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

UCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCN3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P005396:  view genomic region     (about GC identifiers)

Start:
5,406,972 bp from pter      End:
5,416,169 bp from pter
Size:
9,198 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UCN3_HUMAN, Q969E3 (See protein sequence)
Recommended Name: Urocortin-3 precursor  
Size: 161 amino acids; 17961 Da
Subunit: Binds with high affinity to CRF receptors 2-alpha and 2-beta
2 PDB 3D structures from and Proteopedia for UCN3:
2RMH (3D)        3N93 (3D)    
Secondary accessions: Q496H2 Q5SR91

Explore the universe of human proteins at neXtProt for UCN3: NX_Q969E3

Explore proteomics data for UCN3 at MOPED


See UCN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_444277.2  
ENSEMBL proteins: 
 ENSP00000369798  

UCN3 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for UCN3

 
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antibodies-online proteins for UCN3 (8 products) 

 
antibodies-online peptides for UCN3

UCN3 Antibody Products:

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antibodies-online antibodies for UCN3 (35 products) 

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antibodies-online kits for UCN3 (13 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

1 InterPro protein domain:
 IPR024270 Urocortin_II/III

Graphical View of Domain Structure for InterPro Entry Q969E3

ProtoNet protein and cluster: Q969E3

UniProtKB/Swiss-Prot: UCN3_HUMAN, Q969E3
Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


Find genes that share domains with UCN3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: UCN3_HUMAN, Q969E3
Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an
endogenous ligand for maintaining homeostasis after stress

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
GO:0005515protein binding ----
GO:0051431corticotropin-releasing hormone receptor 2 binding IEA--
     
Find genes that share ontologies with UCN3           About GenesLikeMe


Phenotypes:
     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ucn3):
 behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system  nervous system 

Find genes that share phenotypes with UCN3           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Ucn3tm1Pbl for UCN3

   genOway: Develop your customized and physiologically relevant rodent model for UCN3

miRNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN3

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
UCN3_HUMAN, Q969E3: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2
endoplasmic reticulum1
mitochondrion1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--
GO:0030424axon ----
GO:0043005neuron projection ----
GO:0043196varicosity IEA--
GO:0043679axon terminus IEA--

Find genes that share ontologies with UCN3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for UCN3 About    
See pathways by source

SuperPathContained pathways About
1G-Beta Gamma Signaling
CRHR Pathway0.44
2Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for UCN3
    CRHR Pathway


1 PharmGKB Pathway for UCN3
    Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UCN3
Interactions:

    Search GeneGlobe Interaction Network for UCN3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for UCN3 (Q969E33 ENSP000003697984) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IL10RBQ083343, ENSP000002902004I2D: score=2 STRING: ENSP00000290200
CRHR1P349983, ENSP000003813334I2D: score=1 STRING: ENSP00000381333
CRHR2Q133243I2D: score=1 
--ENSP000002228364STRING: ENSP00000222836
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Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006950response to stress ----
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA--
GO:0007586digestion IEA--
GO:0009749response to glucose IEA--
GO:0031669cellular response to nutrient levels IEA--

Find genes that share ontologies with UCN3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for UCN3

6 Novoseek inferred chemical compound relationships for UCN3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
sauvagine 83.2 1 18052377 (1)
astressin 81.1 1 12970166 (1)
acth 33.1 3 16626608 (2), 15165722 (1)
adenylate 29.5 2 12401516 (1), 12746280 (1)
nitric oxide 0 3 11854458 (2), 15784708 (1)
glucose 0 2 12810578 (1), 18337115 (1)



Find genes that share compounds with UCN3           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for UCN3 gene: 
NM_053049.2  

Unigene Cluster for UCN3:

Urocortin 3
Hs.511775  [show with all ESTs]
Unigene Representative Sequence: NM_053049
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000380433(uc001ihx.1)
miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat UCN3
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GenScript: all cDNA clones in your preferred vector: UCN3 (NM_053049)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN3
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  QuantiTect SYBR Green Assays in human, mouse, rat UCN3
  QuantiFast Probe-based Assays in human, mouse, rat UCN3

Additional mRNA sequence: 

AY026949.1 BC069530.1 BC100867.2 BC100868.1 BC100869.1 BC100870.1 

1 DOTS entry:

DT.97835590 

12 AceView cDNA sequences:

BM310953 BQ270989 BQ776556 BM310655 NM_053049 BQ778217 BQ776877 BC069530 
AY026949 AW293249 BQ777111 CA950349 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UCN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AACCTCCTCT
UCN3 Expression
About this image


UCN3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Brain (Nervous System)    fully expand to see all 14 entries
         Thalamus
         Septum   
 
 Pancreas (Endocrine System)
UCN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

UCN3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.511775
    Custom PCR Arrays for UCN3
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for UCN3 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ucn31 , 5 urocortin 31, 5 74.33(n)1
64.6(a)1
  13 (2.20 cM)5
834281  NM_031250.51  NP_112540.21 
 39406885 
chicken
(Gallus gallus)
Aves UCN31 urocortin 3 (stresscopin) 70.8(n)
64.34(a)
  769274  XM_001231710.2  XP_001231711.1 
lizard
(Anolis carolinensis)
Reptilia UCN36
urocortin 3
55(a)
1 ↔ 1
5(3754592-3755056)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004883361 urocortin-3-like 62.69(n)
61.19(a)
  100488336  XM_002931846.2  XP_002931892.1 
zebrafish
(Danio rerio)
Actinopterygii ucn3l1 urocortin 3, like 59.4(n)
48.12(a)
  100003848  NM_001082954.2  NP_001076423.1 


ENSEMBL Gene Tree for UCN3 (if available)
TreeFam Gene Tree for UCN3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UCN3 (see all 470)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs107952671,2
C,F,A--5404983(+) ATGAAC/TGAATG 1 -- us2k111Minor allele frequency- T:0.38NA WA CSA EA 372
rs760926561,2
--5404991(+) ATGAAG/TGAACT 1 -- us2k10--------
rs1119354971,2
C--5405012(+) GAACT-/AATG/ 
AATGAATG
AATGA
1 -- us2k11CSA 2
rs667643951,2
C--5405013(+) AACTA-/AATG  
        
ATGAA
1 -- us2k10--------
rs750206441,2
C--5405014(+) ATGAA-/TGAA  
        
CTAAT
1 -- us2k10--------
rs1170897501,2
F--5405048(+) TGAATG/CAATGA 1 -- us2k11Minor allele frequency- C:0.02EA 120
rs1919320901,2
--5405050(+) AATGAA/CTGAAG 1 -- us2k10--------
rs1476189411,2
--5405063(+) ATGAAC/TTTGAA 1 -- us2k10--------
rs1408476641,2
--5405110(+) TCAAGA/GGGATC 1 -- us2k10--------
rs1841328411,2
--5405256(+) ATGGGC/TTTTAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for UCN3 (5406972 - 5416169 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for UCN3:    About this table    
Variant IDTypeSubtypePubMed ID
esv2669711CNV Deletion23128226
esv2660343CNV Deletion23128226
nsv894783CNV Loss21882294
nsv894792CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing UCN3
DNA2.0 Custom Variant and Variant Library Synthesis for UCN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605901    OMIM disorders: --

1 disease for UCN3:    
About MalaCards
pheochromocytoma


Find genes that share disorders with UCN3           About GenesLikeMe

5 Novoseek inferred disease relationships for UCN3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
adrenal tumor 42.9 4 16095756 (2), 15914529 (1)
pheochromocytoma 19 3 16095756 (2), 15914529 (1)
tumors 0 2 16095756 (1), 15914529 (1)
obesity 0 1 17183713 (1)
heart failure 0 1 15320806 (1)

Genetic Association Database (GAD): UCN3
Human Genome Epidemiology (HuGE) Navigator: UCN3 (3 documents)

Export disorders for UCN3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for UCN3 gene, integrated from 10 sources (see all 70):
(articles sorted by number of sources associating them with UCN3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. (PubMed id 11416224)1, 2, 3, 9 Lewis K.... Vale W.W. (Proc. Natl. Acad. Sci. U.S.A. 2001)
  2. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PubMed id 11329063)1, 2, 9 Hsu S.Y. and Hsueh A.J.W. (Nat. Med. 2001)
  3. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PubMed id 18504423)1, 4 Wong M.L....Licinio J. (Mol. Psychiatry 2008)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Expression of urocortin III/stresscopin in human heart and kidney. (PubMed id 15070962)1, 9 Takahashi K....Shibahara S. (J. Clin. Endocrinol. Metab. 2004)
  6. Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors. (PubMed id 16095756)1, 9 Takahashi K....Murakami O. (Peptides 2006)
  7. Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. (PubMed id 16626608)1, 9 Imperatore A....Petraglia F. (Am. J. Obstet. Gynecol. 2006)
  8. Suppression of progesterone production by stresscopin/urocortin 3 in cultured human granulosa-lutein cells. (PubMed id 19351656)1, 9 Yata A....Maruo T. (Hum. Reprod. 2009)
  9. Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions. (PubMed id 15949638)1, 9 Saruta M....Sasano H. (Peptides 2005)
  10. Ancient evolution of stress-regulating peptides in vertebrates. (PubMed id 15476935)1, 9 Chang C.L. and Hsu S.Y. (Peptides 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 114131 HGNC: 17781 AceView: UCN3 Ensembl:ENSG00000178473 euGenes: HUgn114131
ECgene: UCN3 H-InvDB: UCN3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UCN3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UCN3 gene:
Search GeneIP for patents involving UCN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from genOway)
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