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Aliases for UCN2 Gene

Aliases for UCN2 Gene

  • Urocortin 2 2 3 5
  • Stresscopin-Related Peptide 3 4
  • Urocortin-Related Peptide 3 4
  • Prepro-Urocortin 2 2 3
  • Urocortin II 3 4
  • Ucn II 3 4
  • SRP 3 4
  • URP 3 4
  • Urocortin-2 3
  • UCN-II 3
  • UCNI 3
  • UR 3

External Ids for UCN2 Gene

Previous GeneCards Identifiers for UCN2 Gene

  • GC03M048560
  • GC03M048575
  • GC03M048599

Summaries for UCN2 Gene

Entrez Gene Summary for UCN2 Gene

  • This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCN2 Gene

UCN2 (Urocortin 2) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for UCN2 Gene

  • Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Gene Wiki entry for UCN2 Gene

Additional gene information for UCN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCN2 Gene

Genomics for UCN2 Gene

Regulatory Elements for UCN2 Gene

Enhancers for UCN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H048464 1.4 ENCODE dbSUPER 10.6 +93.7 93685 11.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 TMA7 ATRIP SHISA5 ENSG00000244380 CCDC51 PLXNB1 ENSG00000223343 COL7A1 PFKFB4 UCN2
GH03H048477 1.1 Ensembl ENCODE dbSUPER 11 +84.9 84851 2.9 MAX ZFHX2 IKZF1 MLLT1 IKZF2 MYC RUNX3 EGR2 ZXDB TMA7 SHISA5 ATRIP ENSG00000244380 CCDC51 PFKFB4 UCN2 COL7A1 FBXW12 SLC26A6
GH03H048543 1 Ensembl ENCODE dbSUPER 11.6 +20.3 20294 1 POLR2A ZNF624 RCOR1 GABPA UCN2 COL7A1 SHISA5 ATRIP CCDC51 TMA7 ENSG00000244380 ARIH2OS FBXW12 CDC25A
GH03H048632 1 ENCODE 11.5 -71.3 -71256 4.1 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLI4 ZNF2 GLIS2 ZNF143 WDR6 COL7A1 UCN2 PFKFB4 MIR6824 SLC26A6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UCN2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UCN2 gene promoter:

Genomic Locations for UCN2 Gene

Genomic Locations for UCN2 Gene
2,056 bases
Minus strand

Genomic View for UCN2 Gene

Genes around UCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCN2 Gene

Proteins for UCN2 Gene

  • Protein details for UCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9BUG0

    Protein attributes for UCN2 Gene

    112 amino acids
    Molecular mass:
    12146 Da
    Quaternary structure:
    • Binds with high affinity to CRF receptors 2-alpha and 2-beta.

    Three dimensional structures from OCA and Proteopedia for UCN2 Gene

neXtProt entry for UCN2 Gene

Post-translational modifications for UCN2 Gene

Other Protein References for UCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UCN2 Gene

Domains & Families for UCN2 Gene

Gene Families for UCN2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for UCN2 Gene

Suggested Antigen Peptide Sequences for UCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with UCN2: view

Function for UCN2 Gene

Molecular function for UCN2 Gene

UniProtKB/Swiss-Prot Function:
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Phenotypes From GWAS Catalog for UCN2 Gene

Gene Ontology (GO) - Molecular Function for UCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005102 receptor binding IPI 11329063
GO:0005179 hormone activity IEA --
GO:0042562 hormone binding IPI 11329063
GO:0051431 corticotropin-releasing hormone receptor 2 binding IEA --
genes like me logo Genes that share ontologies with UCN2: view
genes like me logo Genes that share phenotypes with UCN2: view

Animal Models for UCN2 Gene

MGI Knock Outs for UCN2:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UCN2 Gene

Localization for UCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCN2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCN2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with UCN2: view

Pathways & Interactions for UCN2 Gene

genes like me logo Genes that share pathways with UCN2: view

Pathways by source for UCN2 Gene

Gene Ontology (GO) - Biological Process for UCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006171 cAMP biosynthetic process IEP 11329063
GO:0006950 response to stress NAS 11329063
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007586 digestion NAS 11329063
GO:0031669 cellular response to nutrient levels IBA --
genes like me logo Genes that share ontologies with UCN2: view

No data available for SIGNOR curated interactions for UCN2 Gene

Drugs & Compounds for UCN2 Gene

(11) Drugs for UCN2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urocortin (rat) Pharma 0

(4) Additional Compounds for UCN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for UCN2 Gene

Compound Action Cas Number
Urocortin (rat) 171543-83-2
genes like me logo Genes that share compounds with UCN2: view

Drug Products

Transcripts for UCN2 Gene

mRNA/cDNA for UCN2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCN2 Gene

Urocortin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCN2 Gene

No ASD Table

Relevant External Links for UCN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UCN2 Gene:


SOURCE GeneReport for Unigene cluster for UCN2 Gene:


Evidence on tissue expression from TISSUES for UCN2 Gene

  • Skin(4.3)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with UCN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCN2 Gene

Orthologs for UCN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UCN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia UCN2 33 34
  • 79.28 (n)
(Bos Taurus)
Mammalia UCN2 33 34
  • 78.08 (n)
(Rattus norvegicus)
Mammalia Ucn2 33
  • 75.62 (n)
(Mus musculus)
Mammalia Ucn2 33 16 34
  • 72.97 (n)
Species where no ortholog for UCN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UCN2 Gene

Gene Tree for UCN2 (if available)
Gene Tree for UCN2 (if available)

Paralogs for UCN2 Gene

No data available for Paralogs for UCN2 Gene

Variants for UCN2 Gene

Sequence variations from dbSNP and Humsavar for UCN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs143457874 Pathogenic 48,565,636(+) CTCAC(A/G)TGATC nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs387906604 Pathogenic 48,565,458(-) GCTCC(C/T)AGCTC nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs138595277 Likely benign 48,565,090(+) CGCTG(-/G/GGA/GGC/GGGC/GGT/TGC)GCAGC intron-variant, upstream-variant-2KB
rs139014122 Uncertain significance 48,565,433(+) AGACG(A/C/T)GGAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs148454724 Uncertain significance 48,565,161(+) TACTC(A/G)GAGTA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UCN2 Gene

Variant ID Type Subtype PubMed ID
nsv954484 CNV deletion 24416366
nsv834685 CNV loss 17160897
nsv523981 CNV loss 19592680
nsv3811 CNV deletion 18451855
nsv236349 CNV deletion 16902084
nsv1152618 CNV duplication 26484159
nsv1004383 CNV loss 25217958
esv8924 CNV gain 19470904
esv2725247 CNV deletion 23290073
esv1540436 CNV deletion 17803354
esv1008877 CNV deletion 20482838

Variation tolerance for UCN2 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCN2 Gene

Disorders for UCN2 Gene

Relevant External Links for UCN2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UCN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCN2 Gene

Publications for UCN2 Gene

  1. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PMID: 11329063) Hsu SY … Hsueh AJ (Nature medicine 2001) 2 3 4 22 60
  2. Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products. (PMID: 23493376) Vaughan JM … Vale WW (Endocrinology 2013) 3 4 60
  3. Urocortin 2 stimulates estradiol secretion from cultured human placental cells: an effect mediated by the type 2 corticotrophin-releasing hormone (CRH) receptor. (PMID: 19417223) Imperatore A … Challis JR (Reproductive sciences (Thousand Oaks, Calif.) 2009) 3 22 60
  4. Common and divergent structural features of a series of corticotropin releasing factor-related peptides. (PMID: 18052377) Grace CR … Riek R (Journal of the American Chemical Society 2007) 4 22 60
  5. Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats. (PMID: 16223946) Czimmer J … Taché Y (American journal of physiology. Gastrointestinal and liver physiology 2006) 3 22 60

Products for UCN2 Gene

Sources for UCN2 Gene

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