Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UCN2 Gene

Aliases for UCN2 Gene

  • Urocortin 2 2 3
  • SRP 3 4 6
  • Stresscopin-Related Peptide 3 4
  • Urocortin-Related Peptide 3 4
  • Prepro-Urocortin 2 2 3
  • Urocortin II 3 4
  • Ucn II 3 4
  • URP 3 4
  • UR 3 6
  • Urocortin-2 3
  • UCN-II 3
  • UCNI 3

External Ids for UCN2 Gene

Summaries for UCN2 Gene

Entrez Gene Summary for UCN2 Gene

  • This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCN2 Gene

UCN2 (Urocortin 2) is a Protein Coding gene. Diseases associated with UCN2 include alcohol dependence. Among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. GO annotations related to this gene include receptor binding and hormone binding.

UniProtKB/Swiss-Prot for UCN2 Gene

  • Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress

Gene Wiki entry for UCN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCN2 Gene

Genomics for UCN2 Gene

Genomic Location for UCN2 Gene

Start:
48,561,718 bp from pter
End:
48,563,773 bp from pter
Size:
2,056 bases
Orientation:
Minus strand

Genomic View for UCN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCN2 Gene

Regulatory Elements for UCN2 Gene

Transcription factor binding sites by QIAGEN in the UCN2 gene promoter:

Proteins for UCN2 Gene

  • Protein details for UCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RP3-UCN2_HUMAN
    Recommended name:
    Urocortin-2
    Protein Accession:
    Q96RP3
    Secondary Accessions:
    • Q9BUG0

    Protein attributes for UCN2 Gene

    Size:
    112 amino acids
    Molecular mass:
    12146 Da
    Quaternary structure:
    • Binds with high affinity to CRF receptors 2-alpha and 2-beta.

    Three dimensional structures from OCA and Proteopedia for UCN2 Gene

neXtProt entry for UCN2 Gene

Proteomics data for UCN2 Gene at MOPED

Post-translational modifications for UCN2 Gene

Other Protein References for UCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UCN2 Gene

Domains for UCN2 Gene

Gene Families for UCN2 Gene

HGNC:

Suggested Antigen Peptide Sequences for UCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RP3

UniProtKB/Swiss-Prot:

UCN2_HUMAN
Family:
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.:
    • Q96RP3
genes like me logo Genes that share domains with UCN2: view

Function for UCN2 Gene

Molecular function for UCN2 Gene

UniProtKB/Swiss-Prot Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress

Gene Ontology (GO) - Molecular Function for UCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005102 receptor binding IPI 11329063
GO:0005179 hormone activity IEA --
GO:0005515 protein binding --
GO:0042562 hormone binding IPI 11329063
genes like me logo Genes that share ontologies with UCN2: view
genes like me logo Genes that share phenotypes with UCN2: view

Animal Models for UCN2 Gene

MGI Knock Outs for UCN2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for UCN2 Gene

Localization for UCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCN2 Gene COMPARTMENTS Subcellular localization image for UCN2 gene
Compartment Confidence
extracellular 5
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11329063
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with UCN2: view

Pathways for UCN2 Gene

genes like me logo Genes that share pathways with UCN2: view

Pathways by source for UCN2 Gene

1 PharmGKB pathway for UCN2 Gene

Interacting Proteins for UCN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273610%0d%0a9606.ENSP00000290200%0d%0a9606.ENSP00000340943%0d%0a
Selected Interacting proteins: ENSP00000273610 Q96RP3-UCN2_HUMAN for UCN2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for UCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006171 cAMP biosynthetic process IEP 11329063
GO:0006950 response to stress NAS 11329063
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007586 digestion NAS 11329063
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with UCN2: view

Compounds for UCN2 Gene

(14) Novoseek inferred chemical compound relationships for UCN2 Gene

Compound -log(P) Hits PubMed IDs
sauvagine 79.3 3
octadecaneuropeptide 73.6 2
adenylate 21.3 3
acth 16.1 3
amphetamine 14.2 2
genes like me logo Genes that share compounds with UCN2: view

Transcripts for UCN2 Gene

mRNA/cDNA for UCN2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCN2 Gene

Urocortin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCN2 Gene

No ASD Table

Relevant External Links for UCN2 Gene

GeneLoc Exon Structure for
UCN2
ECgene alternative splicing isoforms for
UCN2

Expression for UCN2 Gene

mRNA expression in normal human tissues for UCN2 Gene

SOURCE GeneReport for Unigene cluster for UCN2 Gene Hs.631914

genes like me logo Genes that share expressions with UCN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for UCN2 Gene

Orthologs for UCN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UCN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UCN2 35
  • 78.08 (n)
  • 69.37 (a)
UCN2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCN2 35
  • 79.28 (n)
  • 68.47 (a)
UCN2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ucn2 35
  • 72.97 (n)
  • 60.36 (a)
Ucn2 16
Ucn2 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ucn2 35
  • 75.62 (n)
  • 63.89 (a)
Species with no ortholog for UCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UCN2 Gene

ENSEMBL:
Gene Tree for UCN2 (if available)
TreeFam:
Gene Tree for UCN2 (if available)

Paralogs for UCN2 Gene

No data available for Paralogs for UCN2 Gene

Variants for UCN2 Gene

Sequence variations from dbSNP and Humsavar for UCN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs423561 -- 48,562,713(+) CATCC(A/G)TCCAG utr-variant-3-prime
rs1079134 -- 48,561,789(-) TGTAT(A/G)TAGCA utr-variant-3-prime
rs2633965 -- 48,562,859(-) GGGCT(A/T)GCTCC reference, missense
rs9839959 -- 48,562,465(+) CTTAC(A/G)TGGCA utr-variant-3-prime
rs9845083 -- 48,563,221(+) tgaca(C/G)agcgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCN2 Gene

Variant ID Type Subtype PubMed ID
nsv523981 CNV Loss 19592680
nsv834685 CNV Loss 17160897
nsv876762 CNV Loss 21882294
esv2725247 CNV Deletion 23290073
esv1008877 CNV Deletion 20482838
esv1540436 CNV Deletion 17803354
nsv236349 CNV Loss 16902084
nsv3811 CNV Loss 18451855

Relevant External Links for UCN2 Gene

HapMap Linkage Disequilibrium report
UCN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCN2 Gene

Disorders for UCN2 Gene

(1) MalaCards Diseases for UCN2 Gene

Search for UCN2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UCN2 Gene

(7) Novoseek inferred disease relationships for UCN2 Gene

Disease -log(P) Hits PubMed IDs
anxiety depression 27.3 1
obesity 3.74 1
colitis ulcerative 1.86 2
shock 0.273 2
atrophy 0 1

Relevant External Links for UCN2

Human Genome Epidemiology (HuGE) Navigator
UCN2
genes like me logo Genes that share disorders with UCN2: view

No data available for UniProtKB/Swiss-Prot for UCN2 Gene

Publications for UCN2 Gene

  1. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PMID: 11329063) Hsu S.Y. … Hsueh A.J.W. (Nat. Med. 2001) 2 3 4 23
  2. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. (PMID: 11416224) Lewis K. … Vale W.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23
  3. Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility. (PMID: 14592950) Karteris E. … Grammatopoulos D. (Endocrinology 2004) 3 23
  4. Ancient evolution of stress-regulating peptides in vertebrates. (PMID: 15476935) Chang C.L. … Hsu S.Y. (Peptides 2004) 3 23
  5. Modifications of the human urocortin 2 peptide that improve pharmacological properties. (PMID: 16476507) Isfort R.J. … Mazur A.W. (Peptides 2006) 3 23

Products for UCN2 Gene

Sources for UCN2 Gene

Back to Top

Content