UCN2 Gene
protein-coding GIFtS: 47
GCID: GC03M048575
|
|
urocortin 2
| |
Aliases
for UCN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Urocortin 21 2 | | Ucn II2 3 | | SRP1 2 3 5 | | Urocortin II2 3 | | URP1 2 3 | | Urocortin-Related Peptide2 3 | | UCN-II1 2 | | UR2 5 | | UCNI1 2 | | Urocortin-21 | | Stresscopin-Related Peptide2 3 | | |
Export aliases for UCN2 gene to outside databasesPrevious GC identifer: GC03M048560 |
Summaries
for UCN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UCN2:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related tothe corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family namesimilarity, the product of this gene has no sequence similarity to urotensin II. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UCN2_HUMAN, Q96RP3Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent anendogenous ligand for maintaining homeostasis after stress
Gene Wiki entry for UCN2
|
Genomic Views
for UCN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UCN2 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for UCN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3UCN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M048575: view genomic region
(about GC identifiers)
Start:
|
48,599,151 bp from pter |
End:
|
48,601,206 bp from pter |
Size:
|
2,056 bases |
Orientation:
|
minus strand |
|
Proteins
for UCN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UCN2_HUMAN, Q96RP3 (See
protein sequence)Recommended Name: Urocortin-2 precursor Size: 112 amino acids; 12146 Da
Subunit: Binds with high affinity to CRF receptors 2-alpha and 2-beta
Subcellular location: Secreted
2 PDB 3D structures from  and Proteopedia  for UCN2:2RMG (3D)
3N95 (3D)
Secondary accessions: Q9BUG0Explore the universe of human proteins at neXtProt for UCN2: NX_Q96RP3
UCN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149976.1
ENSEMBL proteins: ENSP00000273610
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
UCN2 for ontologies About GeneDecksing
UCN2 Antibody Products:
Assay Products for UCN2: |
Protein
Domains /
Families
for UCN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UCN2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96RP3ProtoNet protein and cluster: Q96RP3 1 Blocks protein family: IPB000187 Corticotropin-releasing factor
UniProtKB/Swiss-Prot: UCN2_HUMAN, Q96RP3Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family |
Function
for UCN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UCN2_HUMAN, Q96RP3Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent anendogenous ligand for maintaining homeostasis after stress
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UCN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
UCN2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for UCN2:
Animal Models:
Mouse knock-out Ucn2tm1Pbl for UCN2
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ucn2):
UCN2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for UCN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glucocorticoid Pathway (HPA Axis), Pharmacodynamics | |
1  PharmGKB Pathway for UCN2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCN2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for UCN2 (Q96RP33 ENSP000002736104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
UCN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for UCN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UCN2 for compounds About GeneDecksing
 Browse Tocris compounds for UCN2
10/14 Novoseek chemical compound relationships for UCN2 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sauvagine |
79.3 |
4 |
15189041 (1), 11416224 (1), 18052377 (1) |
| octadecaneuropeptide |
73.6 |
2 |
15146610 (1), 15107726 (1) |
| adenylate |
21.3 |
3 |
20171993 (1), 12401516 (1), 12746280 (1) |
| acth |
16.1 |
3 |
16626608 (2), 15165722 (1) |
| amphetamine |
14.2 |
2 |
15146610 (1), 15107726 (1) |
| nitric oxide |
0 |
3 |
11854458 (2), 15784708 (1) |
| glucose |
0 |
1 |
18337115 (1) |
| gaba |
0 |
2 |
15146610 (1), 15107726 (1) |
| glutamate |
0 |
2 |
15146610 (1), 15107726 (1) |
| histamine |
0 |
2 |
15146610 (1), 15107726 (1) |
Search CenterWatch for drugs/clinical trials and news about UCN2
|
Transcripts
for UCN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UCN2 gene: NM_033199.3 Unigene Cluster for UCN2: Urocortin 2 Hs.631914 [show with all ESTs]Unigene Representative Sequence: BC0026471 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000273610(uc003cty.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UCN2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UCN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UCN2 (NM_033199) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UCN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN2 |
Additional cDNA sequence: AF320560.1 BC002647.2 BC022096.1 2 DOTS entries: DT.91679727 DT.91679723 24/139 AceView cDNA sequences (see all 139): L06862 AA844717 AI884355 BQ876206 AA598507 CA454344 AL043852 BM556873 CB305511 BM717410 BM674773 BM562726 BC002647 CA446804 AL119886 BG769332 BM468243 NM_033199 BC022096 AF320560 BE622276 BQ073708 AW630655 AL043851
GeneLoc Exon Structure
|
Expression
for UCN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UCN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See UCN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCN2
SOURCE GeneReport for Unigene cluster: Hs.631914
SABiosciences Custom PCR Arrays for UCN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UCN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UCN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN2 |
Orthologs
for UCN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for UCN2 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for UCN2 (if available)
TreeFam Gene Tree for UCN2 (if available) |
Paralogs
for UCN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UCN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UCN2 (48599151 - 48601206 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UCN2
1 Indel: 60417 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UCN2 |
|
Disorders
/ Diseases
for UCN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UCN2 for disorders About GeneDecksing
OMIM gene information: 605902
OMIM disorders: --
16  diseases for UCN2: About MalaCardsellis-van creveld syndrome asphyxiating thoracic dystrophy systolic heart failure presbyopia
polydactyly alcohol dependence polymyositis dermatomyositis
obesity hematopoiesis alcoholism endometriosis
osteoarthritis periodontitis hypoxia neuronitis
7 Novoseek disease relationships for UCN2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: UCN2 (14 documents)
Export disorders for UCN2 gene to outside databases
|
Publications
for UCN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UCN2 gene, integrated from 9 sources (see all 104):
(articles sorted by number of sources associating them with UCN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PubMed id 11329063)1, 2, 3, 9 Hsu S.Y. and Hsueh A.J.W. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility. (PubMed id 14592950)1, 9 Karteris E....Grammatopoulos D. (2004)
- Urocortin 2 stimulates estradiol secretion from cultured human placental cells: an effect mediated by the type 2 corticotrophin-releasing hormone (CRH) receptor. (PubMed id 19417223)1, 9 Imperatore A....Challis J.R. (2009)
- Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. (PubMed id 16626608)1, 9 Imperatore A....Petraglia F. (2006)
- Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. (PubMed id 11226328)1, 9 Reyes T.M....Sawchenko P.E. (2001)
- Modifications of the human urocortin 2 peptide that improve pharmacological properties. (PubMed id 16476507)1, 9 Isfort R.J....Mazur A.W. (2006)
- Ancient evolution of stress-regulating peptides in vertebrates. (PubMed id 15476935)1, 9 Chang C.L. and Hsu S.Y. (2004)
- Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. (PubMed id 11416224)1, 9 Lewis K.... Vale W.W. (2001)
- Common and divergent structural features of a series of corticotropin releasing factor-related peptides. (PubMed id 18052377)2, 9 Grace C.R.R....Riek R. (2007)
|
External Searches for UCN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UCN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UCN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UCN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UCN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UCN2 gene:
Search GeneIP for patents involving UCN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UCN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UCN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UCN2 | | | OriGene Protein Over-expression Lysate for UCN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UCN2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UCN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UCN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UCN2 | | OriGene Custom Protein Services for UCN2 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UCN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UCN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCN2 |
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| |  |  |  |  | | | | |
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 | | | UCN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for UCN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN2 |
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