Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UCN2 Gene

Aliases for UCN2 Gene

  • Urocortin 2 2 3 5
  • Stresscopin-Related Peptide 3 4
  • Urocortin-Related Peptide 3 4
  • Prepro-Urocortin 2 2 3
  • Urocortin II 3 4
  • Ucn II 3 4
  • SRP 3 4
  • URP 3 4
  • UCN-II 3
  • UCNI 3
  • UR 3

External Ids for UCN2 Gene

Previous GeneCards Identifiers for UCN2 Gene

  • GC03M048560
  • GC03M048575
  • GC03M048599

Summaries for UCN2 Gene

Entrez Gene Summary for UCN2 Gene

  • This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCN2 Gene

UCN2 (Urocortin 2) is a Protein Coding gene. Diseases associated with UCN2 include Chemical Colitis. Among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for UCN2 Gene

  • Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Gene Wiki entry for UCN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCN2 Gene

Genomics for UCN2 Gene

Regulatory Elements for UCN2 Gene

Enhancers for UCN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UCN2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UCN2 gene promoter:

Genomic Location for UCN2 Gene

Chromosome:
3
Start:
48,561,718 bp from pter
End:
48,563,773 bp from pter
Size:
2,056 bases
Orientation:
Minus strand

Genomic View for UCN2 Gene

Genes around UCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCN2 Gene

Proteins for UCN2 Gene

  • Protein details for UCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RP3-UCN2_HUMAN
    Recommended name:
    Urocortin-2
    Protein Accession:
    Q96RP3
    Secondary Accessions:
    • Q9BUG0

    Protein attributes for UCN2 Gene

    Size:
    112 amino acids
    Molecular mass:
    12146 Da
    Quaternary structure:
    • Binds with high affinity to CRF receptors 2-alpha and 2-beta.

    Three dimensional structures from OCA and Proteopedia for UCN2 Gene

neXtProt entry for UCN2 Gene

Proteomics data for UCN2 Gene at MOPED

Post-translational modifications for UCN2 Gene

Other Protein References for UCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UCN2 Gene

Domains & Families for UCN2 Gene

Gene Families for UCN2 Gene

Protein Domains for UCN2 Gene

Suggested Antigen Peptide Sequences for UCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RP3

UniProtKB/Swiss-Prot:

UCN2_HUMAN :
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Family:
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with UCN2: view

Function for UCN2 Gene

Molecular function for UCN2 Gene

UniProtKB/Swiss-Prot Function:
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Gene Ontology (GO) - Molecular Function for UCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042562 hormone binding IPI 11329063
genes like me logo Genes that share ontologies with UCN2: view
genes like me logo Genes that share phenotypes with UCN2: view

Animal Models for UCN2 Gene

MGI Knock Outs for UCN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for UCN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UCN2 Gene

Localization for UCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCN2 Gene COMPARTMENTS Subcellular localization image for UCN2 gene
Compartment Confidence
extracellular 5
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for UCN2 Gene

Pathways & Interactions for UCN2 Gene

genes like me logo Genes that share pathways with UCN2: view

Pathways by source for UCN2 Gene

1 PharmGKB pathway for UCN2 Gene

Interacting Proteins for UCN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273610%0d%0a9606.ENSP00000290200%0d%0a9606.ENSP00000340943%0d%0a
Selected Interacting proteins: ENSP00000273610 Q96RP3-UCN2_HUMAN for UCN2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for UCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress NAS 11329063
GO:0008283 cell proliferation IEA --
GO:0033685 negative regulation of luteinizing hormone secretion IEA --
GO:0035902 response to immobilization stress IEA --
GO:0071385 cellular response to glucocorticoid stimulus IEA --
genes like me logo Genes that share ontologies with UCN2: view

No data available for SIGNOR curated interactions for UCN2 Gene

Drugs & Compounds for UCN2 Gene

(9) Drugs for UCN2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for UCN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UCN2: view

Transcripts for UCN2 Gene

mRNA/cDNA for UCN2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCN2 Gene

Urocortin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCN2 Gene

No ASD Table

Relevant External Links for UCN2 Gene

GeneLoc Exon Structure for
UCN2
ECgene alternative splicing isoforms for
UCN2

Expression for UCN2 Gene

mRNA expression in normal human tissues for UCN2 Gene

SOURCE GeneReport for Unigene cluster for UCN2 Gene Hs.631914

genes like me logo Genes that share expression patterns with UCN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for UCN2 Gene

Orthologs for UCN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UCN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UCN2 35
  • 78.08 (n)
  • 69.37 (a)
UCN2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCN2 35
  • 79.28 (n)
  • 68.47 (a)
UCN2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ucn2 35
  • 72.97 (n)
  • 60.36 (a)
Ucn2 16
Ucn2 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ucn2 35
  • 75.62 (n)
  • 63.89 (a)
Species with no ortholog for UCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UCN2 Gene

ENSEMBL:
Gene Tree for UCN2 (if available)
TreeFam:
Gene Tree for UCN2 (if available)

Paralogs for UCN2 Gene

No data available for Paralogs for UCN2 Gene

Variants for UCN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for UCN2 Gene

Variant ID Type Subtype PubMed ID
nsv523981 CNV Loss 19592680
nsv834685 CNV Loss 17160897
nsv876762 CNV Loss 21882294
esv2725247 CNV Deletion 23290073
esv1008877 CNV Deletion 20482838
esv1540436 CNV Deletion 17803354
nsv236349 CNV Loss 16902084
nsv3811 CNV Loss 18451855

Variation tolerance for UCN2 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for UCN2 Gene

Disorders for UCN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UCN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chemical colitis
- elite association - COSMIC cancer census association via MalaCards
Search UCN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UCN2

Human Genome Epidemiology (HuGE) Navigator
UCN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCN2
genes like me logo Genes that share disorders with UCN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCN2 Gene

Publications for UCN2 Gene

  1. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PMID: 11329063) Hsu S.Y. … Hsueh A.J.W. (Nat. Med. 2001) 2 3 4 23 67
  2. Urocortin 2 stimulates estradiol secretion from cultured human placental cells: an effect mediated by the type 2 corticotrophin-releasing hormone (CRH) receptor. (PMID: 19417223) Imperatore A. … Challis J.R. (Reprod Sci 2009) 3 23
  3. Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats. (PMID: 16223946) Czimmer J. … TachAc Y. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006) 3 23
  4. Modifications of the human urocortin 2 peptide that improve pharmacological properties. (PMID: 16476507) Isfort R.J. … Mazur A.W. (Peptides 2006) 3 23
  5. Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. (PMID: 16626608) Imperatore A. … Petraglia F. (Am. J. Obstet. Gynecol. 2006) 3 23

Products for UCN2 Gene

Sources for UCN2 Gene

Content