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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCN2 Gene

protein-coding   GIFtS: 47
GCID: GC03M048575

Urocortin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Urocortin 21 2     Urocortin-Related Peptide2 3
SRP2 3 5     URP2 3
Prepro-Urocortin 21 2     UR2 5
Stresscopin-Related Peptide2 3     UCN-II2
Ucn II2 3     UCNI2
Urocortin II2 3     urocortin-22

External Ids:    HGNC: 184141   Entrez Gene: 902262   Ensembl: ENSG000001450407   OMIM: 6059025   UniProtKB: Q96RP33   

Export aliases for UCN2 gene to outside databases

Previous GC identifer: GC03M048560


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCN2 Gene:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally
related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF
type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene
family name similarity, the product of this gene has no sequence similarity to urotensin II. (provided by RefSeq,
Jul 2008)

GeneCards Summary for UCN2 Gene: 
UCN2 (urocortin 2) is a protein-coding gene. Diseases associated with UCN2 include presbyopia, and ellis-van creveld syndrome. GO annotations related to this gene include hormone binding and receptor binding.

UniProtKB/Swiss-Prot: UCN2_HUMAN, Q96RP3
Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an
endogenous ligand for maintaining homeostasis after stress

Gene Wiki entry for UCN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCN2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

UCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048575:  view genomic region     (about GC identifiers)

Start:
48,599,151 bp from pter      End:
48,601,206 bp from pter
Size:
2,056 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCN2_HUMAN, Q96RP3 (See protein sequence)
Recommended Name: Urocortin-2 precursor  
Size: 112 amino acids; 12146 Da
Subunit: Binds with high affinity to CRF receptors 2-alpha and 2-beta
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for UCN2:
2RMG (3D)        3N95 (3D)    
Secondary accessions: Q9BUG0

Explore the universe of human proteins at neXtProt for UCN2: NX_Q96RP3

Explore proteomics data for UCN2 at MOPED 

UCN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

UCN2 Protein Expression

REFSEQ proteins: NP_149976.1  
ENSEMBL proteins: 
 ENSP00000273610  

Human Recombinant Protein Products for UCN2: 
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OriGene Protein Over-expression Lysate for UCN2
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for UCN2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS11329063
GO:0005615extracellular space IEA--

UCN2 for ontologies           About GeneDecksing



UCN2 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for UCN2 

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Cloud-Clone Corp. ELISAs for UCN2 
Cloud-Clone Corp. CLIAs for UCN2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR024270 Urocortin_II/III
 IPR024273 Urocortin_II
 IPR000187 Corticotropin-releasing_factor

Graphical View of Domain Structure for InterPro Entry Q96RP3

ProtoNet protein and cluster: Q96RP3

1 Blocks protein domain: IPB000187 Corticotropin-releasing factor

UniProtKB/Swiss-Prot: UCN2_HUMAN, Q96RP3
Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


UCN2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: UCN2_HUMAN, Q96RP3
Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an
endogenous ligand for maintaining homeostasis after stress

     Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding ----
GO:0005102receptor binding IPI11329063
GO:0005179hormone activity IEA--
GO:0005515protein binding ----
GO:0042562hormone binding IPI11329063
     
UCN2 for ontologies           About GeneDecksing


Phenotypes:
     4 GenomeRNAi human phenotypes for UCN2:
 Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

     2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ucn2):
 behavior/neurological  homeostasis/metabolism 

UCN2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Ucn2tm1Pbl for UCN2

   inGenious Targeting Laboratory - Custom generated mouse model solutions for UCN2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCN2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCN2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UCN2 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCN2
4 QIAGEN miScript miRNA Assays for microRNAs that regulate UCN2:
hsa-miR-31 hsa-miR-4254 hsa-miR-198 hsa-miR-3116
SwitchGear 3'UTR luciferase reporter plasmidUCN2 3' UTR sequence
Inhib. RNA
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of UCN2

Clone
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GenScript: all cDNA clones in your preferred vector: UCN2 (NM_033199)
Sino Biological Human cDNA Clone for UCN2
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN2
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                     Customized lentivirus expression plasmids for stable overexpression of UCN2 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for UCN2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics



1 PharmGKB Pathway for UCN2
    Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCN2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for UCN2 (Q96RP33 ENSP000002736104) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IL10RBQ083343, ENSP000002902004I2D: score=1 STRING: ENSP00000290200
CRHR2Q133243I2D: score=1 
--ENSP000002228364STRING: ENSP00000222836
About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006171cAMP biosynthetic process IEP11329063
GO:0006950response to stress NAS11329063
GO:0007586digestion NAS11329063
GO:0008283cell proliferation IEA--
GO:0010629negative regulation of gene expression IEA--

UCN2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UCN2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UCN2

10/14 Novoseek inferred chemical compound relationships for UCN2 gene (see all 14)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
sauvagine 79.3 4 15189041 (1), 11416224 (1), 18052377 (1)
octadecaneuropeptide 73.6 2 15146610 (1), 15107726 (1)
adenylate 21.3 3 20171993 (1), 12401516 (1), 12746280 (1)
acth 16.1 3 16626608 (2), 15165722 (1)
amphetamine 14.2 2 15146610 (1), 15107726 (1)
nitric oxide 0 3 11854458 (2), 15784708 (1)
glucose 0 1 18337115 (1)
gaba 0 2 15146610 (1), 15107726 (1)
glutamate 0 2 15146610 (1), 15107726 (1)
histamine 0 2 15146610 (1), 15107726 (1)

Search CenterWatch for drugs/clinical trials and news about UCN2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UCN2 gene: 
NM_033199.3  

Unigene Cluster for UCN2:

Urocortin 2
Hs.631914  [show with all ESTs]
Unigene Representative Sequence: BC002647
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000273610(uc003cty.1)
miRNA
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hsa-miR-31 hsa-miR-4254 hsa-miR-198 hsa-miR-3116
SwitchGear 3'UTR luciferase reporter plasmidUCN2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCN2
Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN2
Sirion Biotech Customized lentivirus for stable overexpression of UCN2 
                     Customized lentivirus expression plasmids for stable overexpression of UCN2 
Primer
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OriGene qPCR primer pairs and template standards for UCN2
OriGene qSTAR qPCR primer pairs in human, mouse for UCN2
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UCN2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCN2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCN2

Additional mRNA sequence: 

AF320560.1 BC002647.2 BC022096.1 

2 DOTS entries:

DT.91679727  DT.91679723 

24/139 AceView cDNA sequences (see all 139):

CA446804 BM468243 AL043852 BQ876206 BE622276 AF320560 AI884355 BC022096 
AA844717 L06862 BM674773 AA598507 CA454344 BQ073708 BQ428279 BM976752 
BM478885 NM_033199 AL043851 M65158 AL119886 BC002647 BM717410 BM556873 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UCN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
UCN2 Expression
About this image


See UCN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCN2

SOURCE GeneReport for Unigene cluster: Hs.631914
    SABiosciences Custom PCR Arrays for UCN2
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for UCN2 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ucn21 , 5 urocortin 21, 5 73.03(n)1
60.91(a)1
  9 (59.63 cM)5
1715301  NM_145077.11  NP_659543.11 
 1089861635 


ENSEMBL Gene Tree for UCN2 (if available)
TreeFam Gene Tree for UCN2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/57 SNPs in UCN2 are shown (see all 57)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1908905751,2
--48598775(+) CTCCCA/GCCAGA 1 -- ds50010--------
rs768278801,2
--48598877(+) CACACC/TGCCTG 1 -- ds50010--------
rs130881741,2
C,F,A--48599131(+) TGCTAT/CATACA 1 -- ds50012Minor allele frequency- C:0.25NA 4
rs10791341,2
C,F--48599222(-) TGTATA/GTAGCA 1 -- ut31 ese31Minor allele frequency- G:0.27MN 184
rs1175836131,2
C,F--48599323(+) TGCGTG/AAAGTG 1 -- ut311Minor allele frequency- A:0.02EA 120
rs1876760071,2
--48599765(+) CTGGTA/CGGAGG 1 -- ut310--------
rs1480076311,2
C--48599785(+) GCTCTC/TGTGTT 1 -- ut310--------
rs133196511,2
C,F,H--48599841(+) CAGGTG/ATTCTG 1 -- ut31 ese317Minor allele frequency- A:0.09NS EA NA CSA WA 2222
rs1930932251,2
C--48599879(+) GACTCA/GCCACA 1 -- ut310--------
rs98399591,2
C,F,H--48599898(+) CTTACG/ATGGCA 1 -- ut31 ese312Minor allele frequency- A:0.11NA NS EA WA CSA 682

HapMap Linkage Disequilibrium report for UCN2 (48599151 - 48601206 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for UCN2:    About this table     
Variant IDTypeSubtypePubMed ID
esv1540436CNV Deletion17803354
esv2725247CNV Deletion23290073
esv1008877CNV Deletion20482838
nsv876762CNV Loss21882294
nsv3811CNV Loss18451855
nsv834685CNV Loss17160897
nsv236349CNV Loss16902084
nsv523981CNV Loss19592680

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing UCN2
DNA2.0 Custom Variant and Variant Library Synthesis for UCN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605902    OMIM disorders: --

16 diseases for UCN2:    About MalaCards
presbyopia    ellis-van creveld syndrome    asphyxiating thoracic dystrophy    systolic heart failure
alcohol dependence    polydactyly    polymyositis    dermatomyositis
hypoxia    endometriosis    obesity    alcoholism
osteoarthritis    periodontitis    endotheliitis    neuronitis

1 disease from the University of Copenhagen DISEASES database for UCN2:
Kidney failure

UCN2 for disorders           About GeneDecksing

7 Novoseek inferred disease relationships for UCN2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
anxiety depression 27.3 1 19120089 (1)
obesity 3.74 1 17627984 (1)
colitis ulcerative 1.86 2 17412781 (1), 15974983 (1)
shock 0.273 2 12574432 (1), 8194585 (1)
atrophy 0 1 16476507 (1)
inflammation 0 4 15883387 (3), 17412781 (1)
edema 0 1 11329063 (1)

Human Genome Epidemiology (HuGE) Navigator: UCN2 (14 documents)

Export disorders for UCN2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for UCN2 gene, integrated from 9 sources (see all 106):
(articles sorted by number of sources associating them with UCN2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PubMed id 11329063)1, 2, 3, 9 Hsu S.Y. and Hsueh A.J.W. (2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility. (PubMed id 14592950)1, 9 Karteris E....Grammatopoulos D. (2004)
  4. Urocortin 2 stimulates estradiol secretion from cultured human placental cells: an effect mediated by the type 2 corticotrophin-releasing hormone (CRH) receptor. (PubMed id 19417223)1, 9 Imperatore A....Challis J.R. (2009)
  5. Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. (PubMed id 16626608)1, 9 Imperatore A....Petraglia F. (2006)
  6. Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. (PubMed id 11226328)1, 9 Reyes T.M....Sawchenko P.E. (2001)
  7. Modifications of the human urocortin 2 peptide that improve pharmacological properties. (PubMed id 16476507)1, 9 Isfort R.J....Mazur A.W. (2006)
  8. Ancient evolution of stress-regulating peptides in vertebrates. (PubMed id 15476935)1, 9 Chang C.L. and Hsu S.Y. (2004)
  9. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. (PubMed id 11416224)1, 9 Lewis K.... Vale W.W. (2001)
  10. Common and divergent structural features of a series of corticotropin releasing factor-related peptides. (PubMed id 18052377)2, 9 Grace C.R.R....Riek R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 90226 HGNC: 18414 AceView: PFKFB4 Ensembl:ENSG00000145040 euGenes: HUgn90226
ECgene: UCN2 H-InvDB: UCN2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UCN2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UCN2 gene:
Search GeneIP for patents involving UCN2

GeneCards and IP:
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